18-07-2023 дата публикации
Номер: CN116444533A
Принадлежит:
The invention provides an amlexanox refining method, which comprises: 1, adding an amlexanox crude product into a solvent 1, stirring, heating, dissolving, filtering while hot, and collecting a filtrate A; step 2, adding purified water into the filtrate, stirring, cooling and crystallizing, collecting a filter cake, and drying the filter cake; step 3, dissolving the dried filter cake with a solvent 2, heating and dissolving until the solution is clear, and filtering while the solution is hot to obtain a filtrate B; and 4, mixing the filtrate B with a crystallization solvent, cooling, crystallizing, centrifuging to obtain a wet amlexanox product, and drying to obtain a finished amlexanox product. The method has the advantages of simplicity, easiness in control, low solvent toxicity and easiness in control of solvent residues. When the method is used for refining the amlexanox crude product, the problem that the residual DMF solvent exceeds the standard is solved, the purity of the amlexanox ...
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