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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 88. Отображено 88.
29-01-2018 дата публикации

PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING BRAIN TUMOR COMPRISING MIDKINE INHIBITOR

Номер: KR1020180009639A
Автор: OH, JIN MI, NAM, DO HYUN, KANG, HYUN JU, KIM, SEA HEE, HAN, SU JI, KONG, DOO SIK
Принадлежит:

Provided are a pharmaceutical composition for treating and/or preventing brain tumor comprising Midkine inhibitors or a combination of Midkine inhibitors and Temozolomide as an active ingredient, and uses for overcoming resistance against Temozolomide treatment of Midkine inhibitors and/or radiation therapy. COPYRIGHT KIPO 2018 ...

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Номер записи: 1
21-12-2017 дата публикации

METHOD AND SYSTEM FOR PROVIDING DEVICE-BASED SERVICE AND APPARATUS THEREFOR

Номер: KR1020170140690A
Автор: LEE, SI YONG, NAM, DO HYUM, CHANG, DEOK MOON, JEON, SANG YOON
Принадлежит:

The present invention relates to a method and a system for providing device-based service, and an apparatus therefor, wherein user information is not essentially requested and various services are provided to a user based on device information. The method for providing a service based on a service device in a service system according to an embodiment of the present invention comprises the steps of: checking identification information on an accessed service device; checking a list of services which can be applied for through the service device based on the identification information on the service device, and transmitting the list of services and a message for notifying payment of service fare to the service device; monitoring whether fare for one or more services included in the list of services is paid; creating a service profile where the one or more services whose fare has been paid are recorded when the monitoring concludes that the fare for the one or more services has been paid; and ...

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Номер записи: 2
23-08-2017 дата публикации

ANTIBODIES AGAINST EPIDERMAL GROWTH FACTOR RECEPTOR VARIANT III AND USES THEREOF

Номер: KR1020170095753A
Автор: NAM, DO HYUN, PARK, HYUN KYU
Принадлежит:

The present invention relates to antibodies against epidermal growth factor receptor variant III (EGFRvIII) or antigen-bonded fractions, nucleic acid coding the same, a vector comprising the nucleic acid, a cell transformed by the vector, a method for manufacturing the antibodies or antigen-bonded fractions, a composition for preventing or treating cancer, a composition for diagnosing cancer and a kit for diagnosing cancer. COPYRIGHT KIPO 2017 ...

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Номер записи: 3
12-01-2017 дата публикации

AUTOMATED CELL CULTIVATION DEVICE, AND METHOD FOR OPERATING CULTIVATION DEVICE

Номер: WO2017007278A1
Автор: NAM, Dohyun, RYU, Gyuha, LEE, Jinku
Принадлежит:

Provided as one embodiment of the present invention is an automated cell cultivation device comprising: an incubator for accommodating at least one container for culturing cells; a microscope for observing the condition of the cells in the container; a robot arm for moving the location of the container; a liquid handler for allowing liquid to flow into the container or discharging liquid from the container; and a control device for controlling the operation of at least one of the incubator, the microscope, the robot arm and the liquid handler.

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Номер записи: 4
03-05-2018 дата публикации

BIOMARKER HGF FOR PREDICTING EFFICACY OF C-MET INHIBITOR

Номер: WO2018080015A1
Автор: SHIM, Seon Hui, KIM, Kyungah, KIM, Bo Gyou, NAM, Do-Hyun
Принадлежит:

Provided are a biomarker HGF for predicting the efficacy of a c-Met inhibitor, and a composition for predicting the efficacy of a c-Met inhibitor, comprising a detection substance for an HGF, and/or for selecting a subject for the application of a c-Met inhibitor.

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Номер записи: 5
07-12-2017 дата публикации

ANTI-NRP1 ANTIBODY SCREENING METHOD

Номер: WO2017209554A3
Автор: NAM, Do-Hyun, LEE, Jae Hyun
Принадлежит:

The present invention relates to a method for screening an anti-NRP1 antibody or an antigen-binding fragment thereof using NRP1-overexpressing patient-derived cells and an animal model comprising the same and, more particularly, to a method for screening an antibody or an antigen-binding fragment thereof through in vitro and in vivo panning using a patient-derived cell containing NRP1 and an animal model transplanted with the same, respectively.

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Номер записи: 6
08-05-2018 дата публикации

BIOMARKER HGF FOR PREDICTING EFFICACY OF C-MET INHIBITOR

Номер: KR1020180046256A
Автор: SHIM, SEON HUI, KIM, KYUNG AH, KIM, BO GYOU, NAM, DO HYUN
Принадлежит:

Provided are a biomarker hepatocyte growth factor (HGF) for predicting the efficacy of a c-Met inhibitor, and a composition for predicting the efficacy of a c-Met inhibitor comprising an HGF detection material and/or for selecting a target of the application of a c-Met inhibitor. One example provides a biomarker for predicting the efficacy of a c-Met inhibitor and/or for selecting a target of the application of a c-Met inhibitor, which comprises one or more selected from the group consisting of an HGF and genes encoding the same. COPYRIGHT KIPO 2018 ...

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Номер записи: 7
22-03-2017 дата публикации

암 치료제 스크리닝 방법

Номер: KR0101718507B1
Автор: 남도현, 설호준
Принадлежит: 사회복지법인 삼성생명공익재단

... 본 발명은 MET 신호전달 경로의 손상에 의해 유발된 암 세포에서 Wnt/β-카테닌 신호전달 경로를 이용하여, MET 신호전달 경로를 표적으로 하는 암 치료제를 스크리닝하는 방법 및 wnt/β-카테닌 신호전달 활성여부 측정제제를 포함하는, MET 신호전달 경로의 손상에 의해 발병된 암에 대한 치료 후보물질의 반응성 예측용 키트에 관한 것이다. 본 발명의 스크리닝 방법 또는 키트를 이용하면, MET 신호전달 경로의 손상에 의해 유발된 암 세포에서, MET 신호전달 경로를 표적으로 하는 암 치료용 후보물질을 보다 효과적이고 용이하게 검출할 수 있으므로, 암 치료제의 개발에 널리 활용될 수 있을 것이다.

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Номер записи: 8
07-09-2018 дата публикации

CELL MIGRATION MEASUREMENT METHOD, AND METHOD FOR SCREENING CELL MIGRATION INHIBITOR USING SAME

Номер: WO2018159966A1
Автор: NAM, Do Hyun, KONG, Doo Sik, RYU, Gyu Ha
Принадлежит:

The present invention relates to a method for measuring cell migration by means of fluorescence observation of cells using a frequency ratio of a three-dimensionally cultured cell in a structure of an upper part of a micro-pillar chip that migrates to a contact surface between the micro-pillar chip and the structure and that adherently grows; and at the same time provides a tool for determining the effectiveness of a drug which is generally the degree of cell migration inhibition according to the concentration of the drug, the toxicity of the drug, and the like by observing and comparing cell activity.

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Номер записи: 9
30-08-2018 дата публикации

PHARMACEUTICAL COMPOSITION COMPRISING COMPOUND CAPABLE OF PENETRATING BLOOD-BRAIN BARRIER AS EFFECTIVE INGREDIENT FOR PREVENTING OR TREATING BRAIN CANCER

Номер: WO2018155947A1
Автор: CHOI, Hwan Geun, PARK, Jong Bae, KO, Eunhwa, SON, Jung Beom, KIM, Nam Doo, LEE, Seung Hoon, NAM, Do-Hyun
Принадлежит:

The present invention relates to a pharmaceutical composition comprising a compound capable of penetrating the blood-brain barrier as an effective ingredient for preventing or treating brain cancer. A pharmaceutical composition for preventing or treating brain cancer according to the present invention efficiently penetrates the blood-brain barrier of the brain to effectively inhibit LRRK2 protein, thus finding useful applications in the prevention or treatment of brain cancer.

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Номер записи: 10
31-10-2019 дата публикации

MAGNETIC-BASED BIOPANNING METHOD THROUGH ATTACHMENT OF MAGNETIC BEAD TO CELL

Номер: WO2019209073A1
Автор: NAM, Do-Hyun, MIN, Byeongkwi
Принадлежит:

The present invention relates to a method for screening an antibody or an antigen-binding fragment thereof by using cells bearing magnetic beads and, more particularly, to a method for screening an antibody binding specifically to an antigen protein or an antigen-binding fragment thereof, in which cells having biotinylated phospholipids in the cell membranes thereof and a streptavidin-magnetic bead complex fused to the surfaces thereof, and a magnetic-based system are utilized.

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Номер записи: 11
04-05-2017 дата публикации

ANTIBODY TO BE CROSS-LINKED TO HUMAN AND MOUSE SEMA3A, AND USE THEREOF

Номер: WO2017074013A1
Автор: NAM, Do Hyun, SHIN, Yong Jae, LEE, Jae Hyun
Принадлежит:

The present invention provides an antibody having the ability to be cross-linked to human Sema3A and mouse Sema3A. The antibody of the present invention can be used as a therapeutic antibody for inhibiting Sema3A in various carcinomas in which Sema3A expression is high, such as glioblastoma, pancreatic cancer and liver cancer. Since Sema3A is considered to be a therapeutic target of diabetic retinopathy, autoimmune arthritis, neuropathic pain and osteoporosis, the antibody of the present invention or an antigen binding fragment thereof can be used as an agent, in addition to being used as an anticancer drug, for treating associated diseases. The antibody of the present invention inhibits the growth of cancer cells derived from various carcinomas, by using high anti-Sema3A binding and Sema3A function inhibition caused thereby, and inhibits the migration of cancer cells by inhibiting the phosphorylation of ERK among the downstream signaling materials of Sema3A, thereby being very effective ...

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Номер записи: 12
06-12-2018 дата публикации

PYRROLO-PYRIMIDINE DERIVATIVE COMPOUND, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME COMPOUND AS EFFECTIVE INGREDIENT FOR PREVENTING OR TREATING PROTEIN KINASE-RELATED DISEASE

Номер: WO2018155916A3
Автор: CHOI, Hwan Geun, PARK, Jong Bae, KO, Eunhwa, SON, Jung Beom, CHO, Joong-heui, KO, Yi Kyung, PARK, Jin-Hee, KIM, So Young, KANG, Seock Yong, LEE, Seungyeon, KIM, Nam Doo, LEE, Yunho, LEE, Sun-Hwa, KIM, Dayea, LEE, Sun Joo, BAE, Jae Hyun, HONG, Eunmi, JANG, Tae-ho, KIM, Sang Bum, LEE, Seung Hoon, NAM, Do-Hyun
Принадлежит:

The present invention relates to a novel pyrrolo-pyrimidine derivative compound, a preparation method therefor, and a pharmaceutical composition comprising the same compound as an effective ingredient for preventing or treating a protein kinase-related disease. The compound represented by Chemical Formula 1 according to the present invention, an optical isomer thereof, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same as an effective ingredient has outstanding inhibitory activity against LRRK2 kinase and against phosphorylation in the NIH-3T3 cell line, which is an LRRK2-expressing cell line, and NCC01 and 448T cell lines, which are both derived from patients with brain tumors. Verified to have inhibitory activity against various protein kinases in addition to LRRK2, the compound can find effective applications in the treatment or prevention of protein kinase-related diseases.

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Номер записи: 13
25-01-2018 дата публикации

PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING BRAIN TUMORS, CONTAINING MIDKINE INHIBITOR

Номер: WO2018016674A1
Автор: OH, Jin Mi, NAM, Do-Hyun, KANG, Hyun Ju, KIM, Sea Hee, HAN, Su Ji, KONG, Doo-Sik
Принадлежит:

Provided are: a pharmaceutical composition for treating and/or preventing brain tumors, containing, as an active ingredient, a Midkine inhibitor or a combination of a Midkine inhibitor and Temozolomide; and a use of a Midkine inhibitor for overcoming resistance to Temozolomide treatment and/or radiotherapy.

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Номер записи: 14
10-08-2017 дата публикации

자동 세포 배양기 및 그 배양기의 동작 방법

Номер: KR0101767336B1
Автор: 남도현, 유규하, 이진구
Принадлежит: 사회복지법인 삼성생명공익재단

... 본 발명의 일 실시예로써, 세포를 배양하기 위한 적어도 하나의 용기를 수용하는 인큐베이터, 용기 내의 세포 상태를 관찰하기 위한 현미경, 용기의 위치를 이동시키기 위한 로봇암, 용기로 액체를 유입시키거나 용기로부터 액체를 유출시키기 위한 액체 취급기 및 인큐베이터, 현미경, 로봇암 및 액체 취급기 중 적어도 하나의 동작을 제어하기 위한 제어 디바이스를 포함하는 자동 세포 배양기가 제공될 수 있다.

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Номер записи: 15
11-05-2017 дата публикации

ANTIBODY CROSS-LINKED TO HUMAN AND MOUSE Sema3A AND USES THEREOF

Номер: KR1020170051213A
Автор: NAM, DO HYUN, SHIN, YONG JAE, LEE, JAE HYUN
Принадлежит:

The present invention provides an antibody having a cross-linking capability to human and mouse Sema3A. According to the present invention, the antibody can be used as an antibody medicine to suppress Sema3A in various cancers such as glioblastoma with high Sema3A expression, pancreatic cancer, liver cancer, etc. Since, Sema3A is considered as a treatment target of diabetic retinopathy, autoimmune arthritis, neuropathy pain, and osteoporosis, the antibody or an antigen-binding fragment can be used as a medicine for related diseases in addition to an anticancer medicine. The antibody suppresses growth of cancer cells originated from various cancers by high anti-Sema3A linkage and Sema3A function suppression, and suppresses ERK phosphorylation in a lower messenger to suppress movements of cancer cells to be very effective in cancer prevention and treatment. COPYRIGHT KIPO 2017 ...

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Номер записи: 16
05-07-2017 дата публикации

절단 가능한 프로브를 이용한 만성골수성백혈병 유전자의 멀티플렉스 검출 방법

Номер: KR0101753833B1
Автор: 김광우, 김종원, 남도현, 기창석
Принадлежит: 사회복지법인 삼성생명공익재단

... 일 구체예는 일 양상은 만성골수성백혈병 유전자에 특이적으로 결합하는 프라이머 쌍 및 상기 프라이머쌍에 의해 증폭되는 만성골수성백혈병 증폭 산물의 내부에 특이적으로 결합하는 절단 가능한 프로브를 포함하는 만성골수성백혈병 유전자의 발현량을 검출하는 검출용 키트를 제공하는 것이고, 다른 구체예는 일 구체예 따른 검출용 키트를 이용하여 시료에 있는 만성골수성백혈병 유전자의 발현량을 측정하는 것이다. 구체예의 방법을 이용할 경우, 낮은 농도의 만성골수성백혈병 유전자의 발현량도 효율적으로 실시간으로 검출하여 만성골수성백혈병 진단 및 예후 진단에 유용하게 이용할 수 있다.

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Номер записи: 17
14-12-2017 дата публикации

METHOD FOR SCREENING ANTI-NRP1 ANTIBODY

Номер: KR1020170138055A
Автор: NAM, DO HYUN, LEE, JAE HYUN
Принадлежит:

The present invention relates to a method for screening an anti-neuropilin 1 (NRP1) antibody or an antigen-binding fragment thereof using cells derived from a patient in which NRP1 is over-expressed and also by using an animal model including the cells. More specifically, the present invention relates to a method for screening an antibody or an antigen-binding fragment thereof via in-vitro and in-vivo panning by respectively using cells derived from a patient having NRP1 and an animal model to which the NRP1 is transplanted. COPYRIGHT KIPO 2018 ...

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Номер записи: 18
07-12-2017 дата публикации

METHOD FOR SCREENING ANTIBODY USING PATIENT-DERIVED CELLS

Номер: WO2017209553A3
Автор: NAM, Do-Hyun
Принадлежит:

The present invention relates to a method for screening an antibody or an antigen binding fragment thereof using patient-derived cells and, more particularly, to a method for screening an antibody specifically binding to an antigen or an antigen binding fragment thereof using patient-derived cells containing the antigen.

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Номер записи: 19
13-10-2017 дата публикации

뉴로필린 1(Neuropilin 1)에 대한 항체 및 이의 용도

Номер: KR0101784451B1
Автор: 남도현, 윤엽, 이재현, 이진구
Принадлежит: 사회복지법인 삼성생명공익재단

... 본 발명은 NRP1(Neuropilin 1)에 대한 항체 또는 이의 항원 결합 단편, 이를 코딩하는 핵산, 상기 핵산을 포함하는 벡터, 상기 벡터로 형질전환된 세포, 상기 항체 또는 그의 항원 결합 단편의 제조방법, 상기 항체 또는 이의 항원 결합 단편을 포함하는 항체-약물 접합체, 및 이의 암 예방 또는 치료용 조성물에 관한 것이다.

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Номер записи: 20
05-09-2018 дата публикации

METHOD FOR MEASURING CELL MOBILITY, AND METHOD FOR SCREENING CELL MOBILITY INHIBITORY COMPOSITION USING SAME

Номер: KR1020180099377A
Автор: NAM, DO HYUN, KONG, DOO SIK, RYU, GYU HA
Принадлежит:

The present invention relates to a method for measuring cell mobility which uses a frequency ratio of three-dimensionally cultured cells migrating from an upper structure of a micropillar chip to a contact surface of the structure and the micropillar chip to be attached and growing after being attached, through the fluorescence observation of the cells. The method of the present invention also provides a tool for determining the efficacy of the drug including the degree of inhibition of cell mobility according to the drug concentration and the toxicity of the drug, etc., by simultaneously measuring and comparing cell activity. COPYRIGHT KIPO 2018 ...

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Номер записи: 21
17-04-2017 дата публикации

BENZOSELNOPHENE-BASED COMPOUND AND ANTIBODY-DRUG CONJUGATE CONTAINING SAME

Номер: KR1020170041562A
Автор: LIM, DONG YEOL, CHOI, HONG LIM, MHETRE AMOL, HUR, SOO HYANG, KIM, SUN YOUNG, NAM, DO HYUN
Принадлежит:

The present invention relates to a benzoselnophene-based compound, and a preparation method thereof, and antibody-drug conjugate (ADC) containing the benzoselnophene-based compound. The present invention provides the benzoselnophene-based compound or a salt thereof. Moreover, the benzoselnophene-based compound and the salt thereof, according to one example of the present invention, can be usefully used for treating and preventing cancer diseases with a maximum efficacy, while exhibiting minimal toxicity. COPYRIGHT KIPO 2017 ...

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Номер записи: 22
22-12-2016 дата публикации

GENE RELATED TO IBRUTINIB SENSITIVITY IN PATIENT WITH GLIOBLASTOMA AND USE THEREOF

Номер: KR1020160147182A
Автор: NAM, DO HYUN, LEE, JIN KU, RYU, GYU HA, SHIN, SANG, CHO, HEE JIN
Принадлежит:

The present invention provides a method for determining sensitivity to ibrutinib or prognosis in a patient with glioblastoma by testing existence of an EGFRvIII mutant and a kit for predicting sensitivity to ibrutinib in a patient with glioblastoma. According to the present invention, the reactivity of ibrutinib which is an inhibitor specific to BTK/BMX/BLK in the patient with glioblastoma can be predicted. The present invention can be used based on that ibrutinib can be administered to a patient with an EGFRvIII mutant. The method for testing existence of the EGFRvIII mutant comprises: (a) a step of isolating nucleic acids or proteins from a biological sample isolated from a subject; and (b) a step of detecting (i) a polynucleotide of sequence number 1 from the isolated nucleic acids or (ii) a protein of sequence number 2 from the isolated proteins. COPYRIGHT KIPO 2017 ...

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Номер записи: 23
07-11-2019 дата публикации

ANTIBODY SPECIFICALLY BINDING TO C-MET, AND USE THEREOF

Номер: WO2019212253A1
Автор: NAM, Do-Hyun, PARK, Hyunkyu, YOON, Yeup
Принадлежит:

The present invention relates to an anti-c-Met antibody that is cross-reactive to human and mouse c-Met, and a use thereof and, more specifically, to: an anti-c-Met antibody or an antigen-binding fragment thereof; a bispecific antibody or an antibody-drug conjugate comprising the antibody or an antigen-binding fragment thereof; a pharmaceutical composition for preventing or treating cancer, comprising same; a nucleic acid coding for the antibody or an antigen-binding fragment thereof; a vector and a host cell comprising the nucleic acid; a method for preparing an anti-c-Met antibody or an antigen-binding fragment thereof by using same; and a co-administered cancer treatment composition containing the anti-c-Met antibody or an antigen-binding fragment thereof and another cancer treatment agent. An antibody binding to c-Met and an antigen-binding fragment thereof, according to the present invention, can bind to human and mouse c-Met with high affinity, and thus more accurate preclinical results ...

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Номер записи: 24
12-12-2018 дата публикации

PYRROLOPYRIMIDINE DERIVATIVE COMPOUND, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING PROTEIN KINASE-RELATED DISEASES PYRROLOPYRIMIDINE DERIVATIVE COMPOUND

Номер: KR1020180132575A
Автор: CHOI HWAN GEUN, PARK JONG BAE, KO EUNHWA, SON JUNG BEOM, CHO JOONG HEUI, KO YI KYUNG, PARK JIN HEE, KIM SO YOUNG, KANG SEOCK YONG, LEE SEUNGYEON, KIM NAM DOO, LEE YUNHO, LEE SUN HWA, KIM DAYEA, LEE SUN JOO, BAE JAE HYUN, HONG EUNMI, JANG TAE HO, KIM SANG BUM, LEE SEUNG HOON, NAM DO HYUN
Принадлежит:

The present invention relates to a noble pyrrolopyrimidine derivative compound, a preparation method thereof, and a pharmaceutical composition for preventing or treating protein kinase-related diseases comprising the pyrrolopyrimidine derivative compound as an active ingredient. According to the present invention, a compound represented by chemical formula 1, optical isomers thereof or pharmaceutically acceptable salts thereof, and a pharmaceutical composition comprising the compound as an active ingredient have superior inhibiting activities with respect to LRRK2 kinase and have excellent phosphorylation inhibiting effects in NIH-3T3 cell line, LRRK2 expression cell line, and NCC01 and 448T cell lines, cell lines derived from a brain tumor patient. Further, it has been checked through experiments that the compound, the optical isomers or the pharmaceutically acceptable salts, and the pharmaceutical composition have inhibiting activities with respect to various protein kinases in addition ...

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Номер записи: 25
09-05-2019 дата публикации

ANTIBODY BINDING TO HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR VARIANT III AND FRAGMENT THEREOF

Номер: WO2019035630A3
Автор: NAM, Do-Hyun, PARK, Hyunkyu
Принадлежит:

The present invention relates to an antibody binding to human epidermal growth factor receptor variant III and a fragment thereof. An antibody and a fragment thereof according to the present invention is characterized by specifically recognizing EGFRvIII alone while minimally binding to EGFR. Because EGFRvIII is a highly cancer-specific antigen, the antibody and the antibody fragment developed in the present invention can find applications in the early diagnosis, prevention, and treatment of cancer. In addition, the antibody-drug conjugates(ADC) or chimeric antigen receptor-T(CAR-T) technology in which a drug or T cells are coupled to the antibody or antibody fragment based on the high specificity for cancer can be applied to maximize therapeutic efficacy and minimize the toxicity that may occur in normal cells. An imaging method or ELISA or IHC method using the antibody or antibody fragment of the present invention conjugated directly with a radioactive isotope or a fluorescent material ...

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Номер записи: 26
21-03-2019 дата публикации

TUMOR-INHIBITING GENE PIP4K2A AND USE THEREOF

Номер: WO2019054744A1
Автор: NAM, Do-Hyun, SHIN, Yong Jae, SA, Jason Kyungha, KIM, Misuk, LEE, Yeri
Принадлежит:

The present invention relates to a tumor-inhibiting gene PIP4K2A and a use thereof, and the tumor-inhibiting gene PIP4K2A according to an aspect is derived via in vivo RNAi screening and can be a novel target useful for cancer treatment and thus be useful for methods for cancer diagnosis and treatment and cancer treatment agent screening.

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Номер записи: 27
11-10-2017 дата публикации

MEDIUM COMPOSITION FOR CULTURING CELLS FROM TUMOR AND CULTURE METHOD

Номер: KR1020170110296A
Автор: NAM, DO HYUN
Принадлежит:

The present invention provides a medium composition for culturing cells from a tumor and a method for culturing cells from a tumor using the same. The medium composition of the present invention can be used to culture various tumor-derived cells such as a brain tumor, a metastatic brain tumor, lung cancer, stomach cancer, and breast cancer, which are not specific carcinomas. The medium composition of the present invention uses a low content of growth factors compared to existing culture conditions to reduce the occurrence of selective cell growth by a specific growth factor, and when the medium composition is cultured using the medium composition of the present invention, high purity tumor stem cells can be obtained. The present invention enables the cells derived from tumor patients to be cultured, and can be utilized in pre-clinical research such as patient-customized drug development and drug screening, and medical parts such as clinical application fields and biomedical fields. COPYRIGHT ...

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Номер записи: 28
07-12-2017 дата публикации

METHOD FOR SCREENING ANTIBODY USING PATIENT-DERIVED CELLS

Номер: WO2017209553A2
Автор: NAM, Do-Hyun
Принадлежит:

The present invention relates to a method for screening an antibody or an antigen binding fragment thereof using patient-derived cells and, more particularly, to a method for screening an antibody specifically binding to an antigen or an antigen binding fragment thereof using patient-derived cells containing the antigen.

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Номер записи: 29
18-07-2013 дата публикации

METHOD FOR MULTIPLEX-DETECTING CHRONIC MYELOGENOUS LEUKEMIA GENE USING CUTTABLE PROBE

Номер: WO2013105775A1
Автор: KIM, Kwang Woo, KIM, Jong Won, NAM, Do Hyun, KI, Chang-Seok
Принадлежит:

One form of one specific example provides a detection kit for detecting the amount of chronic myelogenous leukemia gene expression, comprising one pair of primers which specifically couple to the chronic myelogenous leukemia gene, and a cuttable probe which specifically couples to the inside of a chronic myelogenous leukemia amplification product amplified by the one pair of primers. In another specific example, the amount of the chronic myelogenous leukemia gene expression in a sample is measured by using the detection kit according to the one specific example. When a method according to the specific example is used, the amount of chronic myelogenous leukemia gene expression can be efficiently detected in real time even at a low concentration and thus can be useful in chronic myelogenous leukemia diagnosis and prognosis.

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Номер записи: 30
27-02-2020 дата публикации

PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING BRAIN CANCER, COMPRISING, AS ACTIVE INGREDIENT, COMPOUND CAPABLE OF PENETRATING BLOOD-BRAIN BARRIER

Номер: WO2020040610A1
Автор: CHOI, Hwan Geun, PARK, Jong Bae, KO, Eunhwa, SON, Jung Beom, KIM, Nam Doo, LEE, Seung Hoon, NAM, Do-Hyun
Принадлежит:

The present invention relates to a pharmaceutical composition for preventing or treating brain cancer, comprising, as an active ingredient, a compound capable of penetrating the blood-brain barrier. The pharmaceutical composition for preventing or treating brain cancer, according to the present invention, efficiently penetrates the blood-brain barrier of the brain and effectively inhibits an LRRK2 protein, thereby being effectively usable in the prevention or treatment of brain cancer.

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Номер записи: 31
15-07-2015 дата публикации

Antibodies cross-reactive to Human and Mouse c-Met and Uses thereof

Номер: KR0101536668B1
Автор: 김석형, 남도현, 박현규, 주경민, 이남경
Принадлежит: 사회복지법인 삼성생명공익재단

... 본 발명의 항체는 인간 c-Met에 높은 특이성을 갖는 항체로 마우스 c-Met에 대해서도 교차결합능을 갖는다. 본 발명의 항체 또는 항원 결합 단편은 인간 c-Met 뿐 만 아니라 마우스 c-Met에 특이적으로 결합할 수 있어 마우스 종양모델을 이용한 효능 평가에서 보다 정확한 전임상 결과를 확인할 수 있다. 본 발명의 항체는 높은 항 c-Met 결합 및 이에 따른 c-Met 기능 억제로 인해 다양한 암종 유래 암세포의 성장을 억제하며, c-Met과 하부 신호 전달물질들의 인산화를 억제함으로써 c-Met 신호전달을 억제하고, 신생혈관 형성을 억제함으로써 암의 예방 및 치료에 매우 유효하다.

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Номер записи: 32
16-06-2016 дата публикации

METHOD FOR PREDICTING TREATMENT EFFECT OF EPIDERMAL GROWTH FACTOR RECEPTOR INHIBITOR IN GLIOBLASTOMA

Номер: KR1020160069070A
Автор: NAM, DO HYUN, KIM, JIN KUK, KWON, YONG JUN, LEE, JIN KU
Принадлежит:

The present invention relates to a method for predicting an effectiveness of a treatment effect of a subject with respect to an epidermal growth factor receptor inhibitor. More specifically, when an EGFR copy number is measured in DNA extracted from a subject through a method based on a new generation sequencing (NGS) scheme, it is clarified that sensitivity with respect to a treatment effect of an EGFR inhibitor is significantly high according to the EGFR copy number. Accordingly, the method based on a new generation sequencing (NGS) scheme may be useful as a method for predicting an effectiveness of a treatment effect of a subject with respect to an EGFR inhibitor. COPYRIGHT KIPO 2016 ...

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Номер записи: 33
30-08-2018 дата публикации

PYRROLOPYRIMIDINE DERIVATIVE COMPOUND, METHOD FOR MANUFACTURING SAME, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING PROTEIN KINASE-RELATED DISEASE CONTAINING COMPOUND AS ACTIVE INGREDIENT

Номер: KR1020180097162A
Автор: CHOI, HWAN GEUN, PARK, JONG BAE, KO, EUN HWA, SON, JUNG BEOM, CHO, JOONG HEUI, KO, YI KYUNG, PARK, JIN HEE, KIM, SO YOUNG, KANG, SEOCK YONG, LEE, SEUNG YEON, KIM, NAM DOO, LEE, YUN HO, LEE, SUN HWA, KIM, DA YEA, LEE, SUN JOO, BAE, JAE HYUN, HONG, EUN MI, JANG, TAE HO, KIM, SANG BUM, LEE, SEUNG HOON, NAM, DO HYUN
Принадлежит:

The present invention relates to a novel pyrrolopyrimidine derivative compound, a method for manufacturing the same, and a pharmaceutical composition for preventing or treating a protein kinase-related disease containing the compound as an active ingredient. The pharmaceutical composition comprising the compound represented by chemical formula 1, an optical isomer thereof or a pharmaceutically acceptable salt thereof as an active ingredient is excellent in inhibitory activity against LRRK2 kinase and is excellent in phosphorylation inhibition of an LRRK2 expressing NIH-3T3 cell line, and NCC01 and 448T cell lines derived from brain tumor patients. Furthermore, since the composition is confirmed through experimentation to have inhibitory activity against various protein kinases including LRRK2, the composition can be effectively used for the treatment or prevention of protein kinase-related diseases. COPYRIGHT KIPO 2018 ...

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Номер записи: 34
24-08-2017 дата публикации

ANTIBODY AGAINST EGFRvIII AND USE THEREOF

Номер: WO2017142294A1
Автор: NAM, Do-Hyun, PARK, Hyunkyu
Принадлежит:

The present invention relates to an antibody against epidermal growth factor receptor variant III (EGFRvIII) or an antigen-binding fragment thereof, a nucleic acid encoding the same, a vector carrying the nucleic acid, a cell transformed with the vector, a method for preparing the antibody or an antigen-binding fragment thereof, a composition thereof for preventing or treating cancer, a composition for diagnosing cancer, and a kit for diagnosing cancer.

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Номер записи: 35
15-12-2016 дата публикации

GENE ASSOCIATED WITH IBRUTINIB SUSCEPTIBILITY IN GLIOBLASTOMA PATIENTS, AND USE THEREFOR

Номер: WO2016200120A1
Автор: NAM, Do Hyun, LEE, Jin Ku, RYU, Gyu Ha, SHIN, Sang, CHO, Hee Jin
Принадлежит:

The present invention provides: a method of assessing susceptibility or prognosis of glioblastoma patients with respect to ibrutinib, by testing for the presence of EGFRvⅢ mutation; and a kit for predicting the susceptibility of glioblastoma patients to ibrutinib. Use of the present invention makes it possible to predict reactivity to ibrutinib, which is a BTK/BMX/BLK specific inhibitor, in glioblastoma patients. The present invention can advantageously be used as evidence for allowing the administration of ibrutinib to EGFRvⅢ mutation patients.

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Номер записи: 36
20-02-2020 дата публикации

SUBSTITUTED HETEROARYL DERIVATIVE, METHOD FOR PRODUCING SAME, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING PROTEIN KINASE-RELATED DISEASES WHICH CONTAINS SAME AS ACTIVE INGREDIENT

Номер: WO2020036437A1
Автор: CHOI, Hwan Geun, KO, Eunhua, PARK, Jin-Hee, KO, Yi Kyung, KANG, Seock Yong, KIM, So Young, JANG, Bo Mi, LEE, Seungyeon, LEE, Sun-Hwa, KIM, Dayea, LEE, Sun Joo, KIM, Sang Bum, PARK, Jong Bae, NAM, Do-Hyun
Принадлежит:

The present invention pertains to: a substituted heteroaryl derivative; a method for producing same; and a pharmaceutical composition which contains same as an active ingredient and is for preventing or treating protein kinase-related diseases. Since the substituted heteroaryl derivative has excellent inhibitory activity against various protein kinases including LRRK2, a pharmaceutical composition containing the substituted heteroaryl derivative as an active ingredient can be useful for treating or preventing protein kinase-related diseases.

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Номер записи: 37
07-12-2017 дата публикации

ANTI-NRP1 ANTIBODY SCREENING METHOD

Номер: WO2017209554A2
Автор: NAM, Do-Hyun, LEE, Jae Hyun
Принадлежит:

The present invention relates to a method for screening an anti-NRP1 antibody or an antigen-binding fragment thereof using NRP1-overexpressing patient-derived cells and an animal model comprising the same and, more particularly, to a method for screening an antibody or an antigen-binding fragment thereof through in vitro and in vivo panning using a patient-derived cell containing NRP1 and an animal model transplanted with the same, respectively.

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Номер записи: 38
14-03-2019 дата публикации

CUSTOMIZED GROWTH FACTOR SCREENING SYSTEM FOR CELL CULTURE

Номер: WO2019050314A1
Автор: NAM, Do-Hyun, KANG, Hyun Ju, SHIN, Gayoung
Принадлежит:

Provided is a method for screening a customized growth factor combination for cell culture, comprising: a step of adding, to a culture medium, one or more growth factors and a cell which has been isolated from an individual; a step of culturing the cell; and a step of measuring the cellular growth ability (proliferative activity) of the cell. According to a method for screening cell culture conditions customized for a cell according to an aspect, optimal conditions for cell culture can be efficiently selected.

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Номер записи: 39
14-03-2019 дата публикации

TARGET GENE IDENTIFYING METHOD FOR TUMOR TREATMENT

Номер: WO2018147608A3
Автор: NAM, Do-Hyun, LEE, Jin Ku, SA, Jason Kyung Ha
Принадлежит:

A target gene identifying method for tumor treatment according to the present invention comprises the steps of: taking multiple samples from a patient's tumor; analyzing the multiple samples for genetic variation; subjecting the multiple samples to drug screening to measure drug sensitivity of each sample; analyzing tumor heterogeneity on the basis of the genetic variation analysis result and the drug sensitivity measurement result; and identifying a target gene of the tumor on the basis of the tumor heterogeneity analysis result.

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Номер записи: 40
22-11-2017 дата публикации

LIGHTING CONTROL DEVICE BASED ON INTERNET OF THINGS, AND CONTROL METHOD THEREOF

Номер: KR1020170127799A
Автор: YOU, IN SOO, NOH, SEUNG KWON, NAM, DO HYUN
Принадлежит:

The present invention relates to a lighting control device based on an Internet of things and a control method thereof, and more particularly, to a lighting control device which controls the lighting as a group by transmitting a control signal by a control terminal device of a user input with a user unique approval code. According to an embodiment of the present invention, the lighting control device comprises: a control management server positioned in a management center of a building, communicating with a control terminal device of a user through an Internet network, and controlling a corresponding lighting device or a corresponding group lighting device; and a data collecting device installed in a distribution board positioned in each floor of the building, and collecting data on the corresponding lighting device or the corresponding group lighting device to transmit the same to the control management server through a power line communications network. According to the present invention ...

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Номер записи: 41
21-02-2019 дата публикации

ANTIBODY BINDING TO HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR VARIANT III AND FRAGMENT THEREOF

Номер: WO2019035630A2
Автор: NAM, Do-Hyun, PARK, Hyunkyu
Принадлежит:

The present invention relates to an antibody binding to human epidermal growth factor receptor variant III and a fragment thereof. An antibody and a fragment thereof according to the present invention is characterized by specifically recognizing EGFRvIII alone while minimally binding to EGFR. Because EGFRvIII is a highly cancer-specific antigen, the antibody and the antibody fragment developed in the present invention can find applications in the early diagnosis, prevention, and treatment of cancer. In addition, the antibody-drug conjugates(ADC) or chimeric antigen receptor-T(CAR-T) technology in which a drug or T cells are coupled to the antibody or antibody fragment based on the high specificity for cancer can be applied to maximize therapeutic efficacy and minimize the toxicity that may occur in normal cells. An imaging method or ELISA or IHC method using the antibody or antibody fragment of the present invention conjugated directly with a radioactive isotope or a fluorescent material ...

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Номер записи: 42
04-04-2013 дата публикации

SELENOPHENE-FUSED AROMATIC COMPOUND AND MANUFACTURING METHOD THEREOF

Номер: WO2013048177A3
Автор: LIM, Dongyeol, NAM, Do-Hyun, DUBEY, Rashmi, LEE, Hangeun
Принадлежит:

Provided are a selenophene-fused aromatic compound, and a manufacturing method of the selenophene-fused aromatic compound.

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Номер записи: 43
29-11-2012 дата публикации

DOUBLE-TARGET ANTIBODY FUSED WITH A PEPTIDE AND USE OF SAME

Номер: WO2012161372A1
Автор: YOO, Jin San, LEE, Sang Hoon, LEE, Weon Sup, KIM, Sung-Woo, SHIM, Sang Ryeol, YOO, Jin Sang, KIM, Yeun Ju, SHIN, Hee Young, KIM, Joong Kyu, NAM, Ju Ryung, JEONG, Jong Geun, LEE, Hyuk Joon, YUN, Ji-Hyun, JU, Hye Kyung, JEONG, Bo Young, KIM, Do Yun, LEE, Eun Jin, BYUN, Sang Soon, YOUM, Ju Hee, NAHM, Kyoung Hee, NAM, Do Hyun
Принадлежит:

Disclosed are a double-target antibody, derived from a human monoclonal antibody, that effectively suppresses a signal transduction mechanism for angiogenesis and the propagation of cancer cells by simultaneously neutralizing VEGFR-2 and c-Met, which are both involved in angiogenesis, and a composition comprising said antibody for suppressing angiogenesis and for the treatment of cancer. The double-target antibody according to the present invention simultaneously neutralizes two targets involved in the angiogenesis and propagation of cancer cells. Therefore, the double-target antibody has a good neutralizing property when compared to a conventional single target antibody and is very effective in the treatment of cancer. The present inventor expects better effects from manufacturing the double-target antibody according to the present invention than from a treatment using a single target antibody.

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Номер записи: 44
12-09-2017 дата публикации

교모세포종 환자에서 이브루티닙 감수성과 관련된 유전자 및 그 용도

Номер: KR0101776238B1
Автор: 남도현, 이진구, 유규하, 신상, 조희진
Принадлежит: 사회복지법인 삼성생명공익재단

... 본 발명은 EGFRvⅢ 변이의 존재 여부를 검사하여 교모세포종 환자의 이브루티닙에 대한 감수성 또는 예후를 판단하는 방법 및 교모세포종 환자의 이브루티닙에 대한 감수성 예측용 키트를 제공한다. 본 발명을 이용하면 교모세포종 환자에서 BTK/BMX/BLK 특이적 억제제인 이브루티닙의 반응성을 예측할 수 있다. 본 발명은 EGFRvⅢ 변이 환자에게 이브루티닙을 투약할 수 있는 근거로 유용하게 이용될 수 있다.

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Номер записи: 45
29-05-2017 дата публикации

ScFv 항체 라이브러리, 이의 제조방법 및 이를 이용한 ScFv 항체 스크리닝 방법

Номер: KR0101740030B1
Автор: 남도현, 김석형, 윤엽, 이남경, 주경민, 박현규
Принадлежит: 사회복지법인 삼성생명공익재단

... 본 발명은 ScFv 항체 라이브러리, 이의 제조방법 및 이를 이용한 ScFv 항체 스크리닝 방법에 관한 것으로, 구체적으로 면역 기관 유래 항체의 중쇄 가변 영역 (VH) 및 경쇄 가변영역 (VLκ 또는 VLλ)을 포함하는 ScFv 항체를 파지 표면에 제시하는 라이브러리, 이의 제조방법 및 이를 이용한 ScFv 항체 스크리닝 방법에 관한 것이다.

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Номер записи: 46
04-05-2018 дата публикации

인간 및 마우스 Ｓｅｍａ３Ａ에 교차결합하는 항체 및 그의 용도

Номер: KR0101854529B1
Автор: 남도현, 신용재, 이재현
Принадлежит: (주) 팬젠, 사회복지법인 삼성생명공익재단

... 본 발명은 인간 Sema3A 및 마우스 Sema3A에 대하여 교차결합능을 갖는 항체를 제공한다. 본 발명의 항체는 Sema3A 발현이 높은 교모세포종, 췌장암, 간암 등의 다양한 암종에서 Sema3A를 억제하는 항체 치료제로 사용 가능하다. Sema3A는 당뇨망막병증, 자가면역관절염, 신경병증 통증, 골다공증의 치료 타겟으로 여겨지고 있어 본 발명의 항체 또는 항원 결합 단편은 항암치료제 외에도 관련 질환에 대한 치료제로 사용될 수 있다. 본 발명의 항체는 높은 항 Sema3A 결합 및 이에 따른 Sema3A 기능 억제로 인해 다양한 암종 유래 암세포의 성장을 억제하며, Sema3A의 하위 신호전달물질 중 ERK 인산화를 억제하여 암세포의 이동을 억제함으로써 암의 예방 및 치료에 매우 유효하다.

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Номер записи: 47
30-08-2018 дата публикации

METHOD FOR ISOLATING HUMAN BRAIN TISSUE-DERIVED NEURAL STEM CELL AT HIGH EFFICIENCY

Номер: WO2018155952A9
Автор: JOO, Kyeung-Min, NAM, Hyun, NAM, Do-Hyun, HONG, Seung-Chyul, YEON, Je-Young
Принадлежит:

The present invention relates to a method for cultivation and isolation of neural stem cells whereby neural stem cells can be rapidly proliferated on mass scale and isolated at high efficiency and to a stroke patient-derived human adult neural stem cell, cultured and isolated thereby, for use in implantation.

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Номер записи: 48
07-02-2019 дата публикации

METHOD FOR ISOLATING HUMAN BRAIN TISSUE-DERIVED NEURAL STEM CELL AT HIGH EFFICIENCY

Номер: WO2018155952A3
Автор: JOO, Kyeung-Min, NAM, Hyun, NAM, Do-Hyun, HONG, Seung-Chyul, YEON, Je-Young
Принадлежит:

The present invention relates to a method for cultivation and isolation of neural stem cells whereby neural stem cells can be rapidly proliferated on mass scale and isolated at high efficiency and to a stroke patient-derived human adult neural stem cell, cultured and isolated thereby, for use in implantation.

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Номер записи: 49
06-07-2017 дата публикации

BIOMARKER DKK FOR PREDICTING EFFICACY OF C-MET INHIBITOR

Номер: WO2017116064A1
Автор: KIM, Bo Gyou, LEE, Eunjin, KIM, Kyungah, LEE, Jimin, AHN, Tae Jin, NAM, Do-Hyun
Принадлежит:

Provided are: a biomarker DKK1 for predicting efficacy of a c-Met inhibitor; and a composition for predicting efficacy of a C-Met inhibitor and/or selecting a subject to which the c-Met inhibitor is applied, the composition containing a material for detecting DKK1.

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Номер записи: 50
02-11-2017 дата публикации

BIOMARKER FOR DIAGNOSIS OR PROGNOSIS OF GLIOBLASTOMA AND USE THEREOF

Номер: KR1020170121470A
Автор: NAM, DO HYUN, LEE, IN HEE, LEE, HYE WON, CHANG, NAK HO, CHO, HEE JIN
Принадлежит:

The present invention relates to a biomarker for diagnosis or prognosis of glioblastoma and to use thereof, and more particularly, to CFI, LAMB-1, DCBLD2, ADAMTS14, MMP9 and THY1, which are useful biomarkers for diagnosis or prognosis of glioblastoma. Since the MES-TAM signature associated with the differentiation into mesenchymal stem cells developed in the present invention can predict the prognosis of recurrence of glioblastoma, the MES-TAM signature can be useful by being applied to the development of a new concept of target treatment and anticancer drug targeting the excavated MES-TAM signature. COPYRIGHT KIPO 2017 ...

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Номер записи: 51
19-04-2012 дата публикации

BIOMARKER FOR DIAGNOSING GLIOBLASTOMA OR PREDICTING PROGNOSIS OF GLIOBLASTOMA PATIENTS, AND USE THEREOF

Номер: WO2012050365A3
Автор: NAM, Do Hyun, KIM, Jong Hyun, PARK, Kwan, SHIN, Hyung Jin, HONG, Seung Chyul, LEE, Jung-il, KONG, Doo-Sik, SEOL, Ho Jun, SUH, Yeon-Lim
Принадлежит:

The present invention relates to a biomarker for diagnosing glioblastoma or predicting the prognosis of glioblastoma patients, and a use thereof, and more specifically, to an analysis method of a protein comprising the step of measuring the expression amount of the protein to provide the information necessary for diagnosing glioblastoma or predicting the prognosis of glioblastoma patients by utilizing a protein selected from the group consisting of survivin, cyclinE, DCC, TGF-β, CDC25B, Histone H1, p-EGFR, p-VEGFR2/3 and p16 as a biomarker for diagnosing glioblastoma or predicting the prognosis of glioblastoma patients. Since the proteins discovered through the analysis of the present invention can be applied to predict the prognosis of glioblastoma patients, a kit can be provided for predicting the prognosis of glioblastoma patients using the same and to apply the discovered proteins to develop a novel target therapy with respect to the proteins and an anticancer drug. As a result, the ...

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Номер записи: 52
18-01-2017 дата публикации

AUTOMATIC CELL INCUBATOR AND METHOD FOR OPERATING AUTOMATIC CELL INCUBATOR

Номер: KR1020170007092A
Автор: NAM, DO HYUN, RYU, GYU HA, LEE, JIN KU
Принадлежит:

Provided is an automatic cell incubator. According to an embodiment of the present invention, the automatic cell incubator comprises: an incubator accommodating at least one container for culturing cells; a microscope for observing a state of the cells in the container; a robotic arm for changing a position of the container; a liquid treatment device for introducing or releasing liquid in and out from the container; and a controlling device controlling operations of at least one of the incubator, the microscope, the robotic arm, and the liquid treatment device. COPYRIGHT KIPO 2017 ...

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Номер записи: 53
24-07-2017 дата публикации

교모세포종의 진단 또는 예후 예측용 바이오 마커 및 그 용도

Номер: KR0101760464B1
Автор: 남도현, 김종현, 박관, 신형진, 홍승철, 이정일, 공두식, 설호준, 서연림
Принадлежит: 사회복지법인 삼성생명공익재단

... 본 발명은 교모세포종의 진단 또는 예후 예측을 위한 바이오 마커 및 그 용도에 관한 것으로, 더욱 자세하게는 survivin, cyclinE, DCC, TGF-β, CDC25B, Histone H1, p-EGFR, p-VEGFR2/3 및 p16 로 구성된 군에서 선택되는 단백질을 교모세포종의 진단 또는 예후 예측을 위한 바이오 마커로 활용하여, 교모세포종의 진단 또는 예후 예측에 필요한 정보를 제공하기 위해 상기 단백질의 발현량을 측정하는 단계를 포함하는 단백질의 분석방법에 관한 것이다. 본 발명의 분석을 통해 발굴된 단백질들은 교모세포종 환자의 예후 예측에 적용가능 함으로 이를 이용한 교모세포종 예후 진단용 키트를 제공할 수 있고, 발굴된 단백질들을 대상으로 한 새로운 개념의 표적 치료법 및 항암제 개발에 응용될 수 있어 유용하다. 또한, 이에 따라 관련 산업 분야에 큰 파급효과를 가져올 수 있어 유용하다.

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Номер записи: 54
30-08-2018 дата публикации

PYRROLO-PYRIMIDINE DERIVATIVE COMPOUND, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME COMPOUND AS EFFECTIVE INGREDIENT FOR PREVENTING OR TREATING PROTEIN KINASE-RELATED DISEASE

Номер: WO2018155916A2
Автор: CHOI, Hwan Geun, PARK, Jong Bae, KO, Eunhwa, SON, Jung Beom, CHO, Joong-heui, KO, Yi Kyung, PARK, Jin-Hee, KIM, So Young, KANG, Seock Yong, LEE, Seungyeon, KIM, Nam Doo, LEE, Yunho, LEE, Sun-Hwa, KIM, Dayea, LEE, Sun Joo, BAE, Jae Hyun, HONG, Eunmi, JANG, Tae-ho, KIM, Sang Bum, LEE, Seung Hoon, NAM, Do-Hyun
Принадлежит:

The present invention relates to a novel pyrrolo-pyrimidine derivative compound, a preparation method therefor, and a pharmaceutical composition comprising the same compound as an effective ingredient for preventing or treating a protein kinase-related disease. The compound represented by Chemical Formula 1 according to the present invention, an optical isomer thereof, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same as an effective ingredient has outstanding inhibitory activity against LRRK2 kinase and against phosphorylation in the NIH-3T3 cell line, which is an LRRK2-expressing cell line, and NCC01 and 448T cell lines, which are both derived from patients with brain tumors. Verified to have inhibitory activity against various protein kinases in addition to LRRK2, the compound can find effective applications in the treatment or prevention of protein kinase-related diseases.

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Номер записи: 55
14-06-2016 дата публикации

ANTIBODY AGAINST NEUROPILIN 1 AND USE THEREOF

Номер: KR1020160067767A
Автор: NAM, DO HYUN, YOON, YEUP, LEE, JAE HYUN, LEE, JIN KU
Принадлежит:

The present invention relates to an antibody against neuropilin 1 (NRP1) or an antigen binding fragment thereof, nucleic acid coding the same, a vector comprising the nucleic acid, a cell transformed with the vector, a preparation method of the antibody or the antigen binding fragment thereof, an antibody-drug complex comprising the antibody or the antigen binding fragment thereof, and a composition thereof for preventing or treating cancer. The antibody or the antigen binding fragment thereof bind to NRP1 expressed on the surface of a cell, and are internalized inside the cell. COPYRIGHT KIPO 2016 ...

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Номер записи: 56
30-08-2018 дата публикации

METHOD FOR ISOLATING HUMAN BRAIN TISSUE-DERIVED NEURAL STEM CELL AT HIGH EFFICIENCY

Номер: WO2018155952A2
Автор: JOO, Kyeung-Min, NAM, Hyun, NAM, Do-Hyun, HONG, Seung-Chyul, YEON, Je-Young
Принадлежит:

The present invention relates to a method for cultivation and isolation of neural stem cells whereby neural stem cells can be rapidly proliferated on mass scale and isolated at high efficiency and to a stroke patient-derived human adult neural stem cell, cultured and isolated thereby, for use in implantation.

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Номер записи: 57
07-04-2017 дата публикации

NOVEL METHOD FOR PREPARING SELENYL-SUBSTITUTED AROMATIC ALDEHYDE COMPOUNDS

Номер: KR1020170038770A
Автор: LIM, DONG YEOL, NAM, DO HYUN, DUBEY RASHMI
Принадлежит:

The present invention relates to a novel method for preparing selenyl-substituted aromatic aldehyde compounds. More specifically, the method comprises the step of forming selenolate nucleophile and performing nucleophilic substitution of selenyl-substituted aromatic aldehyde compounds. COPYRIGHT KIPO 2017 ...

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Номер записи: 58
19-04-2012 дата публикации

BIOMARKER FOR DIAGNOSING GLIOBLASTOMA OR PREDICTING PROGNOSIS OF GLIOBLASTOMA PATIENTS, AND USE THEREOF

Номер: WO2012050365A9
Автор: NAM, Do Hyun, KIM, Jong Hyun, PARK, Kwan, SHIN, Hyung Jin, HONG, Seung Chyul, LEE, Jung-il, KONG, Doo-Sik, SEOL, Ho Jun, SUH, Yeon-Lim
Принадлежит:

The present invention relates to a biomarker for diagnosing glioblastoma or predicting the prognosis of glioblastoma patients, and a use thereof, and more specifically, to an analysis method of a protein comprising the step of measuring the expression amount of the protein to provide the information necessary for diagnosing glioblastoma or predicting the prognosis of glioblastoma patients by utilizing a protein selected from the group consisting of survivin, cyclinE, DCC, TGF-β, CDC25B, Histone H1, p-EGFR, p-VEGFR2/3 and p16 as a biomarker for diagnosing glioblastoma or predicting the prognosis of glioblastoma patients. Since the proteins discovered through the analysis of the present invention can be applied to predict the prognosis of glioblastoma patients, a kit can be provided for predicting the prognosis of glioblastoma patients using the same and to apply the discovered proteins to develop a novel target therapy with respect to the proteins and an anticancer drug. As a result, the ...

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Номер записи: 59
04-04-2013 дата публикации

SELENOPHENE-FUSED AROMATIC COMPOUND AND MANUFACTURING METHOD THEREOF

Номер: WO2013048177A2
Автор: LIM, Dongyeol, NAM, Do-Hyun, DUBEY, Rashmi, LEE, Hangeun
Принадлежит:

Provided are a selenophene-fused aromatic compound, and a manufacturing method of the selenophene-fused aromatic compound.

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Номер записи: 60
07-12-2017 дата публикации

BISPECIFIC ANTI-C-MET/ANTI-NRP1 ANTIBODY

Номер: WO2017209351A1
Автор: LEE, Seung Hyun, NAM, Do-Hyun
Принадлежит:

Provided are: a bispecific anti-c-Met/anti-Nrp1 antibody comprising an anti-c-Met antibody or an antigen binding fragment thereof, and an anti-Nrp1 antibody or an antigen binding fragment thereof; and a pharmaceutical composition containing the same.

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Номер записи: 61
06-07-2017 дата публикации

BIOMARKER DKK FOR PREDICTING EFFICACY OF C-MET INHIBITOR

Номер: KR1020170077727A
Автор: KIM, BO GYOU, LEE, EUN JIN, KIM, KYUNG AH, LEE, JI MIN, AHN, TAE JIN, NAM, DO HYUN
Принадлежит:

Provided is a composition for predicting the efficacy of a c-Met inhibitor comprising a biomarker DKK1 for detecting the efficacy of the c-Met inhibitor and a detection substance of DKK1, and/or for selecting a target to be a subject for the c-Met inhibitor. COPYRIGHT KIPO 2017 ...

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Номер записи: 62
28-09-2018 дата публикации

METHOD FOR SEPARATING NEURAL STEM CELL DERIVED FROM HUMAN BRAIN TISSUE HAVING HIGH EFFICIENCY

Номер: KR1020180105278A
Автор: JOO, KYEUNG MIN, NAM, HYUN, NAM, DO HYUN, HONG, SEUNG CHYUL, YEON, JE YOUNG
Принадлежит:

The present invention relates to a method for culturing and separating a neural stem cell capable of rapidly and massively multiplying a neural stem cell and separating the same with high efficiency, and a human adult neural stem cell for transplantation derived from a stroke patient cultured and separated thereby. The method for culturing a neural stem cell comprises the following steps of: acquiring a cell from a brain tissue; treating the cell with collagenase and DNase I or papain, cysteine and DNase I, and separating a single cell; dividing the single cell into two or more tubes to be individually mixed with percoll, and centrifuging and collecting the cell; primarily culturing the collected cell; and passaged culturing the primarily cultured cell. COPYRIGHT KIPO 2018 ...

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Номер записи: 63
09-06-2016 дата публикации

ANTIBODY AGAINST NEUROPILIN 1 AND USE THEREOF

Номер: WO2016089126A1
Автор: NAM, Do-Hyun, YOON, Yeup, LEE, Jae Hyun, LEE, Jin Ku
Принадлежит:

The present invention relates to an antibody against neuropilin 1 (NRP1) or an antigen-binding fragment thereof, a nucleic acid encoding the same, a vector comprising the nucleic acid, cells transformed with the vector, a method for preparing the antibody or the antigen-binding fragment thereof, an antibody-drug conjugate comprising the antibody or the antigen-binding fragment thereof, and a composition of the antibody-drug conjugate for preventing or treating cancers.

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Номер записи: 64
04-01-2017 дата публикации

교모세포종에서 표피 성장인자 수용체 억제제의 치료 효과를 예측하는 방법

Номер: KR0101692044B1
Автор: 남도현, 김진국, 권용준, 이진구
Принадлежит: 사회복지법인 삼성생명공익재단

... 본 발명은 EGFR(epidermal growth factor receptor) 억제제에 대한 대상(subject)의 치료 효과의 유효성(effectiveness) 예측 방법에 관한 것으로, 보다 구체적으로 본 발명은 차세대 유전체 시퀀싱 분석법(New Generation Sequencing, NGS) 기반의 방법을 통하여 대상에서 채취한 DNA에서 EGFR 카피수(copy number)를 측정하였을 때, EGFR 카피수에 따라 EGFR 억제제의 치료 효과에 대한 감수성(sensitivity)이 유의하게 높음을 규명함으로써, EGFR(epidermal growth factor receptor) 억제제에 대한 대상(subject)의 치료 효과의 유효성(effectiveness) 예측방법으로서 유용하게 이용될 수 있다.

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Номер записи: 65
13-12-2017 дата публикации

METHOD OF SCREENING ANTIBODY USING PATIENT-DERIVED CELL

Номер: KR1020170137655A
Автор: NAM, DO HYUN
Принадлежит:

The present invention relates to a method of screening an antibody or an antigen-binding fragment thereof using a patient-derived cell, and more particularly, to a method of screening an antibody or an antigen-binding fragment thereof which specifically binds to an antigen using a patient-derived cell containing the antigen. The present invention is useful for the development of patient-customized therapeutics by being able to produce patient-customized antibodies through the screened antibodies. COPYRIGHT KIPO 2018 ...

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Номер записи: 66
20-08-2018 дата публикации

METHOD FOR IDENTIFYING TARGET GENE FOR TUMOR THERAPY

Номер: KR1020180092395A
Автор: NAM, DO HYUN, LEE, JIN KU, JASON K. SA
Принадлежит:

A method for identifying a target gene for tumor therapy according to the present invention includes the steps of: taking a plurality of samples from a tumor of a patient; analyzing a genetic variation of the plurality of samples; measuring the drug sensitivity of each sample by performing drug screening on the plurality of samples; analyzing the heterogeneity of the tumor using a generic variation analysis result and a drug sensitivity measurement result; and identifying the target gene for tumor therapy by using an analysis result of the heterogeneity of the tumor. Accordingly, the present invention can more reliably identify the target gene for tumor therapy. COPYRIGHT KIPO 2018 (S10) Taking a plurality of samples from a tumor of a patient (S20) Analyzing a genetic variation of the plurality of samples (S30) Measuring the drug sensitivity of the plurality of samples (S40) Analyzing intratumor heterogeneity (S50) Identifying a target gene of the tumor ...

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Номер записи: 67
01-10-2015 дата публикации

CELL ANALYZING APPARATUS AND CELL ANALYZING METHOD

Номер: KR1020150108963A
Автор: LEE, DONG WOO, NAM, DO HYUN, KU, BO SUNG, CHOI, YEON SOOK
Принадлежит:

The present invention relates to a cell analyzing apparatus and a cell analyzing method. The cell analyzing apparatus of the present invention includes: an image processing unit converting the imaged cell colonies into digital signals by photographing cultured cell colonies; an outline extracting unit extracting outlines of the cell colonies from image data obtained from the image processing unit; a size calculating unit calculating sizes of the cell colonies from the extracted outlines; and a selecting unit selecting the grown cell colonies by comparing the sizes of the cell colonies with a preset value. COPYRIGHT KIPO 2015 ...

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Номер записи: 68
19-06-2014 дата публикации

PERSONALIZED ANTI-CANCER AGENT SCREENING SYSTEM

Номер: WO2014092457A1
Автор: NAM, Do Hyun, JOO, Kyeung Min
Принадлежит:

The present invention relates to a personalized anti-cancer agent screening system, to a method for screening a personalized anti-cancer agent using said personalized anti-cancer agent screening system, and to a personalized anti-cancer agent screening apparatus. The personalized anti-cancer agent screening system of the present invention may not only select, from among a variety of candidate anti-cancer agents, the anti-cancer agent which exhibits optimum anti-cancer activity against a target patient-derived cancer cell but also may check in advance the treatment response which may be obtained when the selected anti-cancer agent is administered into the body of the patient. Thus, the personalized anti-cancer agent screening system of the present invention may not only reduce the trial and error and risk accompanied by a cancer treatment but also reduce the cost and time required for the treatment.

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Номер записи: 69
31-10-2013 дата публикации

STEM CELL CULTURE MEDIUM AND METHOD FOR CULTURING STEM CELLS USING SAME

Номер: WO2013162199A1
Автор: NAM, Do Hyun
Принадлежит:

The present invention relates to a stem cell culture medium that can replace conventional stem cell culture mediums that comprise fetal bovine serum, which is a heterologous protein, and, more particularly, to a stem cell culture medium that contains a basal medium and a knock-out serum replacement, and to a method for culturing stem cells using the stem cell culture medium. According to the present invention, the efficiency of cell therapy using stem cells can be remarkably enhanced since high purity stem cells having reduced ability for spontaneous differentiation can be obtained without using fetal bovine serum, which is a heterologous protein, and costly growth factors (EGF, bFGF).

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Номер записи: 70
18-07-2013 дата публикации

METHOD FOR DETECTING C-MET GENE USING CUTTABLE PROBE

Номер: WO2013105774A1
Автор: KIM, Kwang Woo, KIM, Jong Won, NAM, Do Hyun, KI, Chang-Seok
Принадлежит:

One form of one specific example provides a detection kit for detecting the amount of c-Met gene expression comprising one pair of primers which specifically couple to the c-Met gene, and a cuttable probe which specifically couples to the inside of a c-Met amplification product amplified by the one pair of primers. In another specific example, the amount of the c-Met gene expression in a sample is measured by using the detection kit according to the one specific example. When a method according to the specific example is used, c-Met gene expression can be efficiently detected even at a low concentration and can be useful in cancer diagnosis and prognosis.

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Номер записи: 71
11-09-2015 дата публикации

SCFV ANTIBODY LIBRARY, METHOD FOR PREPARING SAME, AND SCFV ANTIBODY SCREENING METHOD USING SAME

Номер: WO2015133882A1
Автор: NAM, Do-Hyun, KIM, Seok-Hyung, YOON, Yeup, LEE, Nam Kyung, JOO, Kyeung Min, PARK, Hyunkyu
Принадлежит:

The present invention relates to a ScFv antibody library, a method for preparing the same, and a ScFv antibody screening method using the same and, specifically, to a library presenting a ScFV antibody comprising a heavy chain variable region (VH) and a light chain variable region (VLκ or VLλ) of an immune organ-derived antibody, to a method for preparing the same, and a ScFv antibody screening method using the same.

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Номер записи: 72
17-09-2015 дата публикации

SINGLE-CHAIN VARIABLE FRAGMENT (ScFv) ANTIBODY LIBRARY, PREPARING METHOD THEREOF, AND SCREENING METHOD OF SINGLE-CHAIN VARIABLE FRAGMENT ANTIBODY USING SAME

Номер: KR1020150105615A
Автор: NAM, DO HYUN, KIM, SEOK HYUNG, YOON, YEUP, LEE, NAM KYUNG, JOO, KYEUNG MIN, PARK, HYUN KYU
Принадлежит:

The present invention relates to a single-chain variable fragment (scFv) antibody library, a preparing method thereof, and a screening method of an scFv antibody using the same and, more specifically, to a library presenting the scFv antibody including a heavy chain variable region (V_H) and a light chain variable region (V_Lk or V_Lλ) of an immune organ-derived antibody; a preparing method thereof; and a screening method of an ScFv antibody using the same. The purpose of the present invention is to screen a human antibody which can be efficiently used for curing or diagnosing a disease. COPYRIGHT KIPO 2015 ...

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Номер записи: 73
15-06-2017 дата публикации

PILLAR STRUCTURE FOR BIOCHIP

Номер: WO2017099544A1
Автор: LEE, Don Jung, SONG, Ho Jeong, LEE, Dong Woo, NAM, Do Hyun
Принадлежит:

Disclosed is a technology related to a pillar structure for a biochip. The pillar structure for the biochip, according to one embodiment of the present invention, comprises: a substrate portion having a plate structure; an inserting pillar portion integrally formed with the substrate portion and protruding downward from the bottom surface of the substrate portion so as to be inserted into a well; and a compensating pillar portion integrally formed with the substrate portion and protruding upward from the top surface of the substrate portion, in correspondence with the inserting pillar portion, thereby preventing partial collapsing of the substrate portion caused during a cooling step when extrusion-molding the pillar structure, and improving the accuracy and the reliability of sample analysis through a microscopic image.

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Номер записи: 74
27-12-2013 дата публикации

METHOD FOR PREPARING PATIENT-SPECIFIC GLIOBLASTOMA ANIMAL MODEL, AND USE THEREOF

Номер: WO2013191512A1
Автор: NAM, Do Hyun, JIN, Ju Yuon, JOO, Kyeung Min
Принадлежит:

The present invention relates to a method for preparing a glioblastoma mouse model, a glioblastoma mouse model prepared by the method, a method for screening a therapeutic agent for glioblastoma by using the mouse model, and a method for providing information for selecting a patient-specific glioblastoma treatment method using the mouse model. The method for preparing a glioblastoma mouse model comprises the steps of: (a) dividing the glioblastoma tissue isolated from a patient into four or more compartments, and collecting one or more fragments from each compartment; (b) isolating glioblastoma cells into single cell units from a mixture of the collected compartments; and (c) orthotopically grafting a graft sample containing the glioblastoma cells isolated at step (b) onto the brain of an immunodeficient mouse. According to the present invention, the glioblastoma mouse model identically exhibits the genetic, morphological and pathological characteristics of parental tumors, and is thus ...

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Номер записи: 75
06-09-2017 дата публикации

벤조셀레노펜계 화합물 및 이를 포함하는 항체-약물 결합체

Номер: KR0101775440B1
Автор: 임동렬, 최홍림, 메트레 아몰, 허수향, 김선영, 남도현
Принадлежит: 세종대학교산학협력단, 사회복지법인 삼성생명공익재단

... 본원은 신규 벤조셀레노펜계 화합물과 이의 제조 방법 및 벤조셀레노펜계 화합물을 포함하는 항체-약물 결합체(antibody-drug conjugate; ADC)에 관한 것이다.

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Номер записи: 76
29-08-2018 дата публикации

IP 통신 서비스를 제공하기 위한 장치, 방법 및 통신 시스템

Номер: KR0101893209B1
Автор: 서경덕, 김태균, 남도현, 장덕문
Принадлежит: 주식회사 케이티

... 제1 단말로부터 전송되는 IP 패킷에 포함된 제1 목적지 IP를 소정의 IP변경 관리 정보에 따라 제2 목적지 IP로 변환 여부를 결정하고, 제2 목적지 IP로 변환 결정된 경우 변환된 제2 목적지 IP가 라우팅 테이블에 포함되는지 확인하고, 제2 목적지 IP로 변환되지 않은 경우 제1 목적지 IP가 상기 라우팅 테이블에 포함되어 있는지 확인한다. 확인 결과에 따라 IP 패킷에 포함된 제1 소스 IP를 제2 소스 IP로 변경하고, 변경된 제2 소스 IP와 목적지 IP를 토대로 제1 단말에서 전송한 IP 패킷을 제2 단말로 보안 IP 통신 또는 공중 IP 통신 중 어느 하나의 통신으로 전송한다.

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Номер записи: 77
19-04-2012 дата публикации

BIOMARKER FOR DIAGNOSING GLIOBLASTOMA OR PREDICTING PROGNOSIS OF GLIOBLASTOMA PATIENTS, AND USE THEREOF

Номер: KR2012050365A2
Автор: NAM, Do Hyun, KIM, Jong Hyun, PARK, Kwan, SHIN, Hyung Jin, HONG, Seung Chyul, LEE, Jung-il, KONG, Doo-Sik, SEOL, Ho Jun, SUH, Yeon-Lim
Принадлежит:

The present invention relates to a biomarker for diagnosing glioblastoma or predicting the prognosis of glioblastoma patients, and a use thereof, and more specifically, to an analysis method of a protein comprising the step of measuring the expression amount of the protein to provide the information necessary for diagnosing glioblastoma or predicting the prognosis of glioblastoma patients by utilizing a protein selected from the group consisting of survivin, cyclinE, DCC, TGF-β, CDC25B, Histone H1, p-EGFR, p-VEGFR2/3 and p16 as a biomarker for diagnosing glioblastoma or predicting the prognosis of glioblastoma patients. Since the proteins discovered through the analysis of the present invention can be applied to predict the prognosis of glioblastoma patients, a kit can be provided for predicting the prognosis of glioblastoma patients using the same and to apply the discovered proteins to develop a novel target therapy with respect to the proteins and an anticancer drug. As a result, the ...

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Номер записи: 78
16-01-2014 дата публикации

PHARMACEUTICAL COMPOSITION COMPRISING AZATHIOPRINE AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING BRAIN TUMORS OR TEMODAL-RESISTANT GLIOBLASTOMAS

Номер: WO2014010948A1
Автор: CHO, Heeyeong, CHOI, Gildon, PARK, Woo Kyu, JEONG, Dae Young, KIM, Hyeon Young, LEE, Sunkyung, NAM, Do Hyun, SEOL, Ho Jun
Принадлежит:

The present invention relates to a pharmaceutical composition comprising azathioprine as an active ingredient for preventing or treating cancer or Temodal-resistant glioblastomas. The azathioprine according to the present invention not only effectively inhibits the proliferation of glioblastomas, but also exhibits excellent effects in treating glioblastoma cancer cells that are resistant to Temodal (temozolomide), which is a conventional therapeutic agent for treating glioblastomas. Therefore, the azathioprine according to the present invention can be effectively used as an active ingredient in a pharmaceutical composition for preventing or treating cancer such as brain tumors (particularly, glioblastomas) or Temodal-resistant glioblastomas.

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Номер записи: 79
21-02-2019 дата публикации

ANTIBODY-DRUG CONJUGATES INCLUDING ANTIBODY AGAINST EGFRVIII

Номер: WO2019035649A1
Автор: CHUNG, Chul-Woong, PARK, Yun-Hee, CHOI, Hyo Jung, SONG, Ho Young, PARK, Kyung Eun, KIM, Sung Min, KIM, Hyoung Rae, KIM, Yong Zu, OH, Yeong Soo, CHAE, Jeiwook, NAM, Do-Hyun, PARK, Hyunkyu, PARK, Chang Sik, CHOI, Min Ji
Принадлежит:

The present invention relates to: novel antibody-drug conjugates (ADC) targeting EGFRvIII; a metabolite for activating the ADCs; a method for producing the ADCs; uses of the ADCs to treat and/or prevent diseases; and uses of the ADCs to produce drugs for treating and/or preventing diseases, more specifically, hyperplasia and/or angiogenesis for example, and cancerous diseases. More specifically, the present invention relates to: an antibody-drug conjugate which includes an antibody binding to epidermal growth factor receptor variant III (EGFRvIII), or includes an antigen-binding fragment of the antibody; and a pharmaceutical composition including same.

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Номер записи: 80
07-07-2017 дата публикации

DEVICE, METHOD AND COMMUNICATION SYSTEM FOR PROVIDING IP COMMUNICATION SERVICE

Номер: KR1020170078482A
Автор: SEO, KYUNG DEOK, KIM, TAE GYUN, NAM, DO HYUN, CHANG, DEOK MOON
Принадлежит:

The present invention provides a device, a method and a communication system for providing an IP communication service, which can perform closed communication access in a public internet network and provide both an IP communication service and a public IP communication service. The IP communication service providing device determines whether to convert a first destination IP including an IP packet which is transmitted from a first terminal into a second destination IP according to predetermined IP change management information, checks whether to include the converted second destination IP to a routing table when conversion to the second destination IP is determined and checks whether to include the first destination IP to the routing table when the second destination IP is not converted. A first source IP included in an IP packet is converted into a second source IP according to the checking result, the IP packet which transmitted from the first terminal is transmitted to a second terminal ...

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Номер записи: 81
27-02-2020 дата публикации

NOVEL USE OF PYRIMIDINE DERIVATIVE COMPRISING LRRK KINASE INHIBITOR AS EFFECTIVE INGREDIENT

Номер: WO2020040591A1
Автор: CHOI, Hwan Geun, PARK, Jong Bae, KO, Eunhwa, SON, Jung Beom, KIM, Nam Doo, LEE, Seung Hoon, NAM, Do-Hyun
Принадлежит:

The present invention relates to a novel use of a pyrimidine derivative comprising an LRRK kinase inhibitor as an effective ingredient. A pharmaceutical composition, provided according to one aspect of the present invention, for prevention or treatment of at least one selected from pancreatic cancer, breast cancer, and lung cancer exhibits an excellent therapeutic effect on cancer in vitro and in vivo and, as such, can be advantageously used as a therapeutic agent for pancreatic cancer, breast cancer, and lung cancer.

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Номер записи: 82
13-12-2017 дата публикации

ANTI-C-MET/ANTI-NRP1 BISPECIFIC ANTIBODY

Номер: KR1020170137470A
Автор: LEE, SEUNG HYUN, NAM, DO HYUN
Принадлежит:

Provided are an anti-c-Met/anti-Nrp1 bispecific antibody, which comprises an anti-c-Met antibody or an antigen-binding fragment thereof, an anti-Nrp1 antibody or an antigen-binding fragment thereof and to a pharmaceutical composition comprising the same. COPYRIGHT KIPO 2018 ...

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Номер записи: 83
29-12-2017 дата публикации

중추신경계 림프종 진단용 조성물 및 이를 이용한 중추신경계 림프종 진단 키트

Номер: KR0101801980B1
Автор: 고영혜, 남도현, 김원석, 김석진
Принадлежит: 사회복지법인 삼성생명공익재단

... 본 발명은 NPFFR2, C4orf7, OSMR, EMCN, TPO, FNDC1, COL12A1 및 MSC로 이루어진 군에서 선택된 1개 이상의 유전자의 발현수준을 측정하는 제제를 포함하는 중추신경계 림프종 진단용 조성물, 상기 조성물을 포함하는 중추신경계 림프종 진단 키트, 상기 유전자의 발현수준을 측정하여 중추신경계 림프종을 진단하는 방법, 중추신경계 림프종 예후 예측용 조성물 및 예후를 예측하는 방법에 관한 것이다. 본 발명은 중추신경계 림프종의 발병 여부 및 예후를 진단할 수 있는 마커들을 제공함으로써, 중추신경계 림프종의 치료 및 예후 관리에 유용한 자료를 제공한다. 또한, 상기 중추신경계 림프종 진단 마커들은 중추신경계 림프종 특이적 항암제 개발연구에 유용하게 이용될 수 있다.

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Номер записи: 84
19-10-2018 дата публикации

인간 뇌 조직 유래 신경줄기세포의 고효율 분리 방법

Номер: KR0101910269B1
Автор: 주경민, 남현, 남도현, 홍승철, 연제영
Принадлежит: 성균관대학교산학협력단

... 본 발명은 신경줄기세포를 신속하게 대량으로 증식시키고 고효율로 분리할 수 있는 신경줄기세포 배양 및 분리 방법 및 이에 의해 배양되고 분리된 뇌졸중 환자로부터 유래된 이식용 인간 성체 신경줄기세포에 대한 것이다.

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Номер записи: 85
16-08-2018 дата публикации

TARGET GENE IDENTIFYING METHOD FOR TUMOR TREATMENT

Номер: WO2018147608A2
Автор: NAM, Do-Hyun, LEE, Jin Ku, SA, Jason Kyung Ha
Принадлежит:

A target gene identifying method for tumor treatment according to the present invention comprises the steps of: taking multiple samples from a patient's tumor; analyzing the multiple samples for genetic variation; subjecting the multiple samples to drug screening to measure drug sensitivity of each sample; analyzing tumor heterogeneity on the basis of the genetic variation analysis result and the drug sensitivity measurement result; and identifying a target gene of the tumor on the basis of the tumor heterogeneity analysis result.

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Номер записи: 86
24-12-2014 дата публикации

PHARMACEUTICAL COMPOSITION CONTAINING TP12 EXPRESSION INHIBITOR OR ACTIVITY INHIBITOR AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING RENAL CELL CANCER

Номер: WO2014204261A1
Автор: NAM, Do Hyun, JOO, Kyeung Min, LEE, Jung Il, JUNG, Byong Chang, LEE, Hye Won
Принадлежит:

The present invention relates to a pharmaceutical composition containing a Tp12 expression inhibitor or an activity inhibitor as an active ingredient for preventing or treating renal cancer. When the expression or activity of Tp12 according to the present invention is inhibited in renal cell cancer cells, the proliferation, anoikis resistance, cell adhesion capacity, cell migration capacity, and cell invasion capacity of cancer cells are degraded. When the Tp12 expression-inhibited renal cell cancer cells are transplanted into a mouse, the tumor growth and tumor metastasis to the lungs are inhibited. Therefore, the Tp12 expression inhibitor or activity inhibitor can be useful in preventing or treating renal cell cancer.

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Номер записи: 87
05-02-2016 дата публикации

Limiting Dilution Assay for Screening of Patient-specific Anti-cancer Agents

Номер: KR0101592305B1
Автор: 남도현, 주경민, 최연숙
Принадлежит: 사회복지법인 삼성생명공익재단

... 본 발명은 환자 맞춤형 항암제를 정확하고 효율적으로 선정하기 위한 스크리닝 방법에 관한 것으로 본 발명에 따르면, 극미량의 암세포를 사용하여 개개인의 유전적 특성을 반영한 환자 맞춤형 항암제를 정확하고 빠르게 선별할 수 있으므로, 새로운 항암제 개발 및 개인 맞춤형 의료 분야에 유용하다.

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Номер записи: 88