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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 25. Отображено 25.
09-07-2018 дата публикации

분지된 링커를 포함하는 항체-약물 접합체 및 이의 제조방법

Номер: KR1020180078329A
Автор: 김용주, 오영수, 채제욱, 송호영, 정철웅, 박윤희, 최효정, 박경은, 김형래, 김진영, 민지영, 김성민, 이병수, 우동현, 정지은, 이수인
Принадлежит:

... 본 발명은 다수의 활성제가 하나 이상의 분지된 링커를 통해 항체에 접합되어 있는, 항체-약물 접합체(ADCs)에 관한 것이다. 분지된 링커는 분지 유닛을 포함할 수 있고, 2개의 활성제는 제2 링커를 통해 분지 유닛에 결합되고, 분지 유닛은 1차 링커에 의해 항체에 결합된다. 활성제는 동일하거나 상이할 수 있다. 이러한 특정 구현예에서, 2개 이상의 상기 분지된 링커는 항체의 중쇄 또는 경쇄의 상이한 C-말단 시스테인에 각각 결합될 수 있는, 항체, 예컨대 2-4 분지된 링커에 접합된다. 분지된 링커는 분지 유닛에 결합된 폴리에틸렌 글리콜 유닛을 포함하는 제1 분지 및 제2 분지를 통해 분지 유닛에 결합되는 하나의 활성제를 포함할 수 있다. 이러한 특정 구현예에서, 2개 이상의 상기 분지된 링커는 항체의 중쇄 또는 경쇄의 상이한 C-말단 시스테인에 각각 결합될 수 있는, 항체, 예컨대 2-4 분지된 링커에 접합된다.

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Номер записи: 1
06-07-2018 дата публикации

펩타이드 그룹을 포함하는 접합체 및 이와 관련된 제조방법

Номер: KR1020180077300A
Автор: 김용주, 오영수, 채제욱, 송호영, 정철웅, 박윤희, 최효정, 박경은, 김형래, 김진영, 민지영, 김성민, 이병수, 우동현, 정지은, 이수인
Принадлежит:

... 몇몇 측면에서, 본 발명은 항체; 링커; 및 적어도 두 개의 활성제를 포함하는 항체-약물 접합체와 관련된다. 바람직한 구체예로서, 링커는 다수의 아미노산의 펩타이드 서열을 포함하고, 적어도 두 개의 활성제는 아미노산의 측쇄와 공유 결합으로 연결된다. 항체-약물 접합체는 자기 희생(self-immolative) 그룹, 바람직하게는 두 개의 자기 희생 그룹을 포함할 수 있다. 링커는 예를 들면 O-치환된 옥심을 포함할 수 있으며, 여기서 옥심의 산소 원자는 옥심과 활성제를 공유 결합으로 연결하는 그룹으로 치환되고; 옥심의 탄소 원자는 옥심과 항체를 공유 결합으로 연결하는 그룹으로 치환된다.

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Номер записи: 2
16-08-2018 дата публикации

METHOD FOR PREPARING 4,5-DIAMINO-SUBSTITUTED PYRIMIDINE DERIVATIVE, AND NOVEL COMPOUND FOR PREPARING SAME

Номер: WO2018147555A1
Автор: AHN, Sei Chang, CHOI, Jeung Soon, JANG, Young Ho, CHAE, Sang Eun, CHO, Young Lag, OH, Yeong Soo, KIM, Yong Zu
Принадлежит:

The present invention relates to: a method for preparing a 4,5-diamino-substituted pyrimidine derivative represented by chemical formula (1) defined in claim 1, the derivative being an intermediate for preparing a cephalosporin derivative; a compound represented by chemical formula (15); and a preparation method therefor, the preparation method comprising the steps of (i) preparing a compound represented by chemical formula (15) defined in claim 1 and a compound represented by chemical formula (17) defined in claim 1, (ii) synthesizing a compound represented by chemical formula (18) defined in claim 1 by reacting the compound represented by chemical formula (15) and the compound represented by chemical formula (17) with a solvent and a base, and (iii) preparing a 4,5-diamino-substituted pyrimidine derivative represented by chemical formula (1) by carrying out a deprotection reaction of the compound represented by chemical formula (18) defined in claim 1.

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Номер записи: 3
23-11-2018 дата публикации

EYEBALL-CORRESPONDING LENS MODULE OF HEAD MOUNTED DISPLAY FOR VIRTUAL REALITY

Номер: KR1020180125417A
Автор: PARK WON HEE, KIM SUNG SEOK, CHEONG JONG HOON, PARK HYEON JU, JI YONG IL, OH YEONG SU, LEE CHUL BAE, KIM HO SEOK, SONG SEONG WOO, YUN NA RA, JANG DONG HO, NAM DA SEUL
Принадлежит:

An eyeball-corresponding lens module of a head mounted display for virtual reality according to the present invention, in the lens module applied to the head mounted display for virtual reality, includes a lens frame in which an opened first fixing hole is formed in a region corresponding the eyeball of a user, a lens fixing unit which is formed in the first fixing hole and includes a second fixing hole opened with a slot type formed in the region corresponding to the eyeball of the user, and a lens formed inside the second fixing hole and movable along the longitudinal direction of the second fixing hole. Accordingly, the present invention can locate the lens to correspond to the eyeballs of various users. COPYRIGHT KIPO 2019 ...

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Номер записи: 4
14-06-2017 дата публикации

COMMUNICATION TERMINAL FOR VEHICLE AND METHOD FOR MEASURING POSITION OF VEHICLE USING SAME

Номер: KR1020170065895A
Автор: WU YONGSHOU
Принадлежит:

Provided are a communication terminal for a vehicle and a method for measuring a position of the vehicle using the same. The method for measuring a position of a vehicle, when a front vehicle viewed from a vehicle is identical to a front vehicle viewed from a target vehicle of which a position is to be measured, comprises: converting a GPS position coordinate of the target vehicle into a relative position coordinate of the target vehicle which can be expressed in a coordinate system of the vehicle having a GPS position coordinate of the vehicle as an origin coordinate; calculating an actual position coordinate of the target vehicle which can be expressed in a local map of the vehicle by using a first distance from the vehicle to the front vehicle and a second distance from the target vehicle to the front vehicle; and calculating a position coordinate in which the relative position coordinate is corrected in accordance with deviation between the relative position coordinate and the actual ...

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Номер записи: 5
08-11-2018 дата публикации

HEAD MOUNT DISPLAY FOR VIRTUAL REALITY HAVING ROTATABLE DISPLAY MODULE

Номер: KR1020180121744A
Автор: PARK, WON HEE, KIM, SUNG SEOK, CHEONG, JONG HOON, PARK, HYEON JU, JI, YONG IL, OH, YEONG SU, LEE, CHUL BAE, KIM, HO SEOK, SONG, SEONG WOO, YUN, NA RA, JANG, DONG HO, NAM, DA SEUL
Принадлежит:

According to the present invention, a heat mount display for virtual reality having a rotatable display module comprises: a lens module including a lens provided at a position corresponding to an eyeball of a user, and mounted on a face of the user; and a display module provided in front of the lens module to transmit a three-dimensional image, and formed to be relatively rotatable to the lens module. The head mount display for virtual reality can easily separate the display module from the front of the eyeball. COPYRIGHT KIPO 2018 ...

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Номер записи: 6
21-11-2018 дата публикации

HEAD MOUNTED DISPLAY FOR VIRTUAL REALITY INCLUDING ROTATABLE DISPLAY MODULE

Номер: KR1020180124818A
Автор: PARK WON HEE, KIM SUNG SEOK, CHEONG JONG HOON, PARK HYEON JU, JI YONG IL, OH YEONG SU, LEE CHUL BAE, KIM HO SEOK, SONG SEONG WOO, YUN NA RA, JANG DONG HO, NAM DA SEUL
Принадлежит:

According to the present invention, a head mounted display for a virtual reality including a rotatable display module includes a lens module including a lens provided in a position corresponding to a user′s eyeball and mounted on a face of a user and a display module which is formed on the front side of the lens module to transmit a 3D image and is relatively rotatable with regard to the lens module. Accordingly, the present invention can easily separate the display module from the front side of the eyeball. COPYRIGHT KIPO 2019 ...

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Номер записи: 7
08-12-2015 дата публикации

COMPOUND COMPRISING SELF-IMMOLATIVE GROUP

Номер: KR1020150137015A
Автор: KIM, YONG ZU, PARK, TAE KYO, WOO, SUNG HO, KIM, SUN YOUNG, CHO, JONG UN, JUNG, DOO HWAN, YANG, JEON, MIN, JI YOUNG, LEE, HYANG SOOK, PARK, YUN HEE, RYU, JEONG HEE, OH, KYU MAN, OH, YEONG SOO, CHAE, JEI WOOK, SONG, HO YOUNG, CHUNG, CHUL WOONG
Принадлежит:

The present invention relates to a compound comprising a self-immolative group. According to the present invention, a compound comprising a self-immolative group can comprise protein having substrate specificity with respect to an aimed target such as oligopeptide, polypeptide, antibodies, etc., and an active agent having specific function or activation such as drugs, toxin, ligands, a probe for detection, etc. COPYRIGHT KIPO 2016 ...

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Номер записи: 8
10-07-2018 дата публикации

자기-희생기를 포함하는 접합체 및 이의 제조방법

Номер: KR1020180079452A
Автор: 김용주, 오영수, 채제욱, 송호영, 정철웅, 박윤희, 최효정, 박경은, 김형래, 김진영, 민지영, 김성민, 이병수, 우동현, 정지은, 이수인
Принадлежит:

... 일부 측면에서, 본 발명은 항체; 링커; 및 활성제를 포함하는 항체-약물 접합체에 관한 것이다. 항체-약물 접합체는 자기 희생기를 포함할 수 있다. 링커는 O-치환된 옥심을 포함할 수 있으며, 예컨대 옥심의 산소 원자는 옥심을 활성제에 공유결합시키는 기로 치환되고, 옥심의 탄소 원자는 옥심을 항체에 공유결합시키는 기로 치환된다.

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Номер записи: 9
22-08-2018 дата публикации

METHOD FOR PREPARING 4,5-DIAMINO SUBSTITUTED PYRIMIDINE DERIVATIVE AND NOVEL COMPOUND FOR PREPARING SAME

Номер: KR1020180093307A
Автор: AHN, SEI CHANG, CHOI, JEUNG SOON, JANG, YOUNG HO, CHAE, SANG EUN, CHO, YOUNG LAG, OH, YEONG SOO, KIM, YONG ZU
Принадлежит:

The present invention relates to a method for preparing a 4, 5-diamino substituted pyrimidine derivative represented by chemical formula (1) defined in the claim 1 as an intermediate for the preparation of a cephalosporin derivative. The method comprises: (i) a step of preparing a compound represented by chemical formula (15) defined in the claim 1 and a compound represented by chemical formula (17) defined in the claim 1; (ii) a step of causing the compound represented by the chemical formula (15) and the compound represented by the chemical formula (17) to react with a solvent and a base, to synthesize the resultant with a compound represented by chemical formula (18) defined in the claim 1; and (iii) a step of carrying out a deprotection reaction of the compound represented by the chemical formula (18) defined in the claim 1 to prepare a 4, 5-diamino substituted pyrimidine derivative represented by the chemical formula (1). In addition, the present invention relates to a compound represented ...

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Номер записи: 10
08-11-2018 дата публикации

EYE LENS MODULE OF HEAD-MOUNTED DISPLAY FOR VIRTUAL REALITY

Номер: KR1020180121745A
Автор: PARK, WON HEE, KIM, SUNG SEOK, CHEONG, JONG HOON, PARK, HYEON JU, JI, YONG IL, OH, YEONG SU, LEE, CHUL BAE, KIM, HO SEOK, SONG, SEONG WOO, YUN, NA RA, JANG, DONG HO, NAM, DA SEUL
Принадлежит:

The present invention relates to an eye lens module of a head-mounted display for virtual reality, which can adjust a position of a lens in consideration of a position of an eye of a user. The lens module applied to the head-mounted display for virtual reality comprises: a lens frame having a first fixing hole opened in an area corresponding to an eye of a user; a lens fixing part provided in the first fixing hole and having a second fixing hole opened in an elongated hole in an area corresponding to the eye of the user; and a lens provided inside the second fixing hole and formed to be movable along a longitudinal direction of the second fixing hole. COPYRIGHT KIPO 2018 ...

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Номер записи: 11
04-10-2018 дата публикации

PYRROLOBENZODIAZEPINE DIMER PRECURSOR AND LIGAND-LINKER CONJUGATE COMPOUND THEREOF

Номер: WO2018182341A1
Автор: SONG, Ho Young, KIM, Sung Min, KIM, Hyoung Rae, PARK, Kyung Eun, CHUNG, Chul-Woong, PARK, Yun-Hee, CHOI, Hyo Jung, LEE, Su In, BAEK, Juyuel, LEE, Hyeun Joung, LEE, Ju Young, OH, Jihye, CHAE, Jeiwook, OH, Yeong Soo, KIM, Yong Zu
Принадлежит:

The present invention relates to a pyrrolobenzodiazepine precursor and a ligand-linker conjugate compound thereof, a composition containing the same, and, in particular, a therapeutic use thereof as an anti-cancer agent. The present invention is industrially useful in that it is possible to target proliferative diseases such as cancer, perform a specific treatment, maximize medicinal effects, and minimize the occurrence of side effects, since the compound itself is very stable, has excellent stability in plasma, and has advantages in terms of toxicity manifestation.

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Номер записи: 12
02-12-2015 дата публикации

APPARATUS AND METHOD FOR DC OFFSET CALIBRATION IN SYSTEM

Номер: KR0101573720B1
Автор: 정미경, 오영수, 고명진
Принадлежит: 삼성전자주식회사

... 본 발명은 시스템의 직류(Direct Current : DC) 옵셋 보정 장치 및 방법에 관한 것이다. 본 발명에 따른 시스템 송신경로 상의 DC 옵셋을 보정하기 위한 DC 옵셋 보정기의 동작 방법은, 시스템의 송신 신호에 적용할 옵셋 값을 가변 설정하는 과정과, 상기 가변 설정된 옵셋 값을 상기 시스템에 전송하는 과정과, 상기 가변 설정된 옵셋 값이 적용된 송신 신호에 대해, 상기 시스템의 안테나 단에서 DC 성분 출력값을 측정하는 과정과, 상기 측정된 DC 성분 출력값이 상기 시스템에서 허용 가능한 값을 가질 시, 상기 가변 설정된 옵셋 값을 상기 시스템에 적용할 최종 옵셋 값으로 결정하는 과정을 포함하는 것을 특징으로 한다.

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Номер записи: 13
17-11-2017 дата публикации

NOVEL AUTOTAXIN INHIBITOR COMPOUND AND PHARMACEUTICAL COMPOSITION CONTAINING SAME

Номер: KR101798840B1
Автор: LEE, DAE YON, CHAE, SANG EUN, JUNG, EUN MI, YANG, EUN HYE, CHOI, YOON JEONG, CHUNG, CHUL WOONG, SHIN, JU HYUN, KIM, YUN KI, KWON, HYUN JIN, RYU, JEONG HEE, BAN, EUN HYE, KIM, YONG ZU, OH, YEONG SOO, CHAE, JEI WOOK
Принадлежит: LEGOCHEM BIOSCIENCES, INC.

The present invention relates to a novel autotaxin inhibitor compound for preventing and treating disease or symptoms due to an increase in concentration of lysophosphatidic acid or activation of autotaxin. The present invention further relates to a pharmaceutical composition containing the same. The novel compound of the present invention is an autotaxin inhibitor which inhibits production of lysophosphatidic acid, and thus is useful for treating or preventing cardiovascular disease, cancer, metabolic disease, kidney disease, liver disease, inflammatory diseases, nervous disease, respiratory disease, desmoid disease, eye disease, cholestatic symptoms, other types of chronic pruritus or acute, or chronic rejection of transplanted organs. COPYRIGHT KIPO 2017 ...

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Номер записи: 14
07-11-2017 дата публикации

TOW FIBER CRIMPING DEVICE FOR CIGARETTE FILTERS

Номер: KR1020170122959A
Автор: OH, YOUNG SU, KIM, YU DAE, KIM, SANG GYUN, KIM, HYO JUN
Принадлежит:

The present invention relates to a tow fiber crimping device for cigarette filters. According to the present invention, provided is a tow fiber crimping device which does not produce foreign substances during a tow fiber crimping process to be suitable to produce hygienic cigarette filters, does not generate heat even after high speed operations, and enhances crimp maintenance state after the crimping process by efficiently setting heat after synthetic fibrous tow is used instead for acetate. COPYRIGHT KIPO 2017 ...

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Номер записи: 15
10-10-2017 дата публикации

METHOD FOR PRODUCING CIGARETTE FILTER USING BIODEGRADABLE POLYLACTIC ACID FIBER TOW

Номер: KR101783247B1
Автор: OH, YOUNG SU, KIM, YU DAE, KIM, SANG GYUN, KIM, HYO JUN, KANG, SEONG JAE, KIL, HYUN WOO, MIN, JOO YEON
Принадлежит: SAMHEUNG CO., LTD., OKONG CORPORATION

The present invention relates to a method for producing a cigarette filter using a biodegradable polylactic acid fiber tow instead of existing acetate fibers. According to the present invention, a cigarette filter is capable of forming the same hardness as existing acetate cigarette filters by bonding or coupling phenomenon between polylactic acid fiber tows, and forming an air flow structure in a regular form in the filter by coupling between fibers. Also, the cigarette filter has no residual solvents while spoilage of tastes of cigarettes does not occur by an adhesive smell by heat after smoking cigarette smoke. Also, when being wasted, the cigarette filter can be biodegraded in a short time. Accordingly, social costs associated with environmental pollution and cigarette butt treatment can be reduced. COPYRIGHT KIPO 2017 ...

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Номер записи: 16
10-10-2018 дата публикации

PYRROLOBENZODIAZEPINE DIMER PRECURSOR AND LIGAND-LINKER CONJUGATE COMPOUND THEREOF

Номер: KR1020180110645A
Автор: SONG HO YOUNG, KIM SUNG MIN, KIM HYOUNG RAE, PARK KYUNG EUN, CHUNG CHUL WOONG, PARK YUN HEE, CHOI HYO JUNG, LEE SU IN, BAEK JUYUEL, LEE HYEUN JOUNG, LEE JU YOUNG, OH JIHYE, CHAE JEIWOOK, OH YEONG SOO, KIM YONG ZU
Принадлежит:

The present invention relates to a pyrrolobenzodiazepine precursor and a ligand-linker conjugate compound thereof, a composition comprising the same and, in particular, a therapeutic use thereof as an anticancer agent. The compound has excellent stability itself and stability in plasma, and has an advantage in terms of toxicity expression. Therefore, the compound is industrially useful in targeting proliferative diseases such as cancer, performing specific treatment, maximizing drug efficacy and minimizing the occurrence of side effects. COPYRIGHT KIPO 2018 ...

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Номер записи: 17
13-09-2018 дата публикации

METHOD FOR MANUFACTURING CURVED SCREEN

Номер: KR1020180101674A
Автор: PARK, WON HEE, KIM, SUNG SEOK, CHEONG, JONG HOON, JI, YONG IL, OH, YEONG SU, KIM, HO SEOK, SONG, SEONG WOO, LEE, CHUL BAE
Принадлежит:

The present invention relates to a method for manufacturing a curved screen having a curvature desired by a user. The method for manufacturing a curved screen comprises: a screen forming step of forming a screen having a predetermined area; a screen curvature changing step of changing a curvature of the screen by disposing a first jig having a preset curvature on one surface of the screen; and a screen finishing step of finishing the sheet by applying the sheet onto the curved screen. COPYRIGHT KIPO 2018 (S100) Screen forming step (S200) Flange cutting step (S300) Screen curvature changing step (S400) Screen fixing step (S500) Screen finishing step (S510) Cut surface filling process ...

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Номер записи: 18
10-10-2018 дата публикации

PYRROLOBENZODIAZEPINE DIMER PRECURSOR AND LIGAND-LINKER CONJUGATE COMPOUND THEREOF

Номер: KR1020180110649A
Автор: SONG HO YOUNG, KIM SUNG MIN, KIM HYOUNG RAE, PARK KYUNG EUN, CHUNG CHUL WOONG, PARK YUN HEE, CHOI HYO JUNG, LEE SU IN, BAEK JUYUEL, LEE HYEUN JOUNG, LEE JU YOUNG, OH JIHYE, CHAE JEIWOOK, OH YEONG SOO, KIM YONG ZU
Принадлежит:

The present invention relates to a pyrrolobenzodiazepine precursor and a ligand-linker conjugate compound thereof, a composition containing the same, and a therapeutic use thereof as an anticancer agent. The pyrrolobenzodiazepine precursor shows stability itself as a compound and excellent stability in plasma, and also ensures advantageous in terms of toxicity, thereby being industrially useful by enabling targeting of proliferative diseases such as cancer, specific treatment, maximization of drug efficacy, and minimization of side effects. COPYRIGHT KIPO 2018 ...

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Номер записи: 19
08-11-2018 дата публикации

WINDOW DIRECT PROJECTION-TYPE SIMULATOR

Номер: KR1020180121743A
Автор: PARK, WON HEE, KIM, SUNG SEOK, CHEONG, JONG HOON, PARK, HYEON JU, JI, YONG IL, OH, YEONG SU, LEE, CHUL BAE, KIM, HO SEOK, SONG, SEONG WOO, YUN, NA RA, JANG, DONG HO, NAM, DA SEUL
Принадлежит:

According to the present invention, a window direct projection-type simulator comprises: a cockpit unit including a boarding part on which a user is boarding, and a window part having at least one window with transparency to secure a field of view in a state where the user is boarding on the boarding part; and a video transmitting unit including at least one projector for projecting a virtual three-dimensional image on the window such that the image is directly projected onto the window. According to the present invention, it is possible to greatly reduce costs for maintenance and construction of the simulator. COPYRIGHT KIPO 2018 ...

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Номер записи: 20
31-07-2018 дата публикации

ASPHALT REINFORCEMENT MATERIAL MANUFACTURING DEVICE USING HOT MELT ADHESIVE SHEET

Номер: KR101883691B1
Автор: LEE, SANG KEUN, OH, YOUNG SOO
Принадлежит: F TO B CORP.

Disclosed is an asphalt reinforcement material using a hot melt adhesive sheet. According to the present invention, the asphalt reinforcement material using a hot melt adhesive sheet comprises: a lattice net made of at least one fiber selected from carbon fiber, aramid fiber, polyester fiber, and glass fiber, and woven in a lattice shape; an adhesive coating layer formed on the lattice net to apply an environmentally water-soluble adhesive to the lattice net such that the environmentally water-soluble adhesive penetrates between the strands of the fabric forming the lattice net to maintain the shape of the lattice net without loosening or breaking the strands; and an adhesive sheet made of a hot melt made of a thermoplastic resin, adhered to and bonded to a back surface or a front surface, or the back surface and the front surface of the lattice net formed with the adhesive coating layer, and adhering the lattice net and asphalt while being melted by heat of the asphalt at the time of reinforcing ...

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Номер записи: 21
13-09-2018 дата публикации

FIXING JIG FOR VERTICAL PROJECTION OF PROJECTOR AND DOME-TYPE SCREEN INCLUDING SAME

Номер: KR1020180101673A
Автор: PARK, WON HEE, KIM, SUNG SEOK, CHEONG, JONG HOON, JI, YONG IL, OH, YEONG SU, KIM, HO SEOK, SONG, SEONG WOO, LEE, CHUL BAE
Принадлежит:

The present invention relates to a fixing jig for vertical projection of a projector and a dome-type screen including the same. The fixing jig includes a base frame unit for fixing the projector, a first reflector for vertically reflecting an image projected to the front side of the projector, a first fixing frame which is combined with the base frame unit and fixes the first reflector, a second reflector for reflecting the image reflected by the first reflector in left and right directions, and a second fixing frame which is combined with the base frame unit and fixes the second reflector. Accordingly, the present invention can implement a wide vertical display range and easily control a position of the image projected on a screen. COPYRIGHT KIPO 2018 ...

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Номер записи: 22
21-02-2019 дата публикации

ANTIBODY-DRUG CONJUGATES INCLUDING ANTIBODY AGAINST EGFRVIII

Номер: WO2019035649A1
Автор: CHUNG, Chul-Woong, PARK, Yun-Hee, CHOI, Hyo Jung, SONG, Ho Young, PARK, Kyung Eun, KIM, Sung Min, KIM, Hyoung Rae, KIM, Yong Zu, OH, Yeong Soo, CHAE, Jeiwook, NAM, Do-Hyun, PARK, Hyunkyu, PARK, Chang Sik, CHOI, Min Ji
Принадлежит:

The present invention relates to: novel antibody-drug conjugates (ADC) targeting EGFRvIII; a metabolite for activating the ADCs; a method for producing the ADCs; uses of the ADCs to treat and/or prevent diseases; and uses of the ADCs to produce drugs for treating and/or preventing diseases, more specifically, hyperplasia and/or angiogenesis for example, and cancerous diseases. More specifically, the present invention relates to: an antibody-drug conjugate which includes an antibody binding to epidermal growth factor receptor variant III (EGFRvIII), or includes an antigen-binding fragment of the antibody; and a pharmaceutical composition including same.

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Номер записи: 23
03-12-2015 дата публикации

COMPOUND CONTAINING SELF-IMMOLATIVE GROUP

Номер: WO2015182984A1
Автор: KIM, Yong Zu, PARK, Tae Kyo, WOO, Sung Ho, KIM, Sun Young, CHO, Jong Un, JUNG, Doo Hwan, YANG, Jeon, MIN, Ji Young, LEE, Hyang Sook, PARK, Yun Hee, RYU, Jeong Hee, OH, Kyu Man, OH, Yeong Soo, CHAE, Jeiwook, SONG, Ho Young, CHUNG, Chul-Woong
Принадлежит:

The present invention relates to a compound containing a self-immolative group. The compound containing a self-immolative group according to the present invention can comprise: a protein (examples: an oligopeptide, a polypeptide, an antibody and the like) having substrate specificity for a desired target; and an activator having a specific function or activity (examples: a drug, a toxin, a ligand, a probe for detection and the like).

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Номер записи: 24
09-06-2016 дата публикации

COMPOUNDS COMPRISING SELF-IMMOLATIVE GROUP

Номер: KR0101628872B1
Автор: 김용주, 박태교, 우성호, 김선영, 조종운, 정두환, 양전, 민지영, 이향숙, 박윤희, 유정희, 오규만, 오영수, 채제욱, 송호영, 정철웅
Принадлежит: 주식회사 레고켐 바이오사이언스

... 본 발명은 자가-희생 기(self-immolative group)를 포함하는 화합물에 관한 것으로, 본 발명에 따른 자가-희생 기를 포함하는 화합물은 목적하는 표적에 대한 기질 특이성을 갖는 단백질(예: 올리고펩티드, 폴리펩티드, 항체 등) 및 특이적 기능 또는 활성을 갖는 활성제(예: 약물, 독소, 리간드, 검출용 탐침 등)를 포함할 수 있다.

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Номер записи: 25