29-09-2017 дата публикации
Номер: KR1020170109514A
Принадлежит:
The present invention relates to a method of preparing gelatin nanoparticles manufactures gelatin nanoparticles by constructing an O/W/O or W/O system without a homogenizer, wherein the gelatin nanoparticles are free from the immune system, have a prolonged circulation time in a human body in comparison with that of hydrophobic particles, have enhanced permeability and retention (EPR) effect against cancer cells, have a size of about 200 nm, and may or may not be loaded with a poorly water soluble drug. The poorly water soluble drug of the present invention comprises paclitaxel, which is a poorly soluble anticancer drug, and Coenzyme Q10, ursodeoxycholic acid, ilaprazole, and imatinib mesylate. Further, the O/W/O and W/O systems each represent a nonpolar/polar/non-volatile nonpolar system and a polar/non-volatile nonpolar system respectively, and more specifically, the O/W/O and W/O systems each represent a poorly soluble drug/gelatin nanoparticle/fatty acid system and a gelatin nanoparticle ...
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