Настройки

Укажите год
-

Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

Подробнее
-

Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

Подробнее

Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
Ведите корректный номера.
Ведите корректный номера.
Ведите корректный номера.
Ведите корректный номера.
Укажите год
Укажите год

Применить Всего найдено 47. Отображено 47.
19-05-2017 дата публикации

GENE CARRIER AND PREPARING METHOD THEREOF

Номер: KR1020170055201A
Принадлежит:

The present invention relates to a gene carrier which has an excellent gene delivery efficiency to a target region and extremely superior in vivo stability, and a preparing method thereof. According to the present invention, the gene carrier reduces cytotoxicity using a phospholipid double membrane, and has improved cell introduction. Also, the loss of target genes due to enzymes in an in vivo environment is prevented to improve gene delivery efficiency. A positive ionic polymer can be effectively used for the gene carrier and a gene treatment using the carrier of the present invention, by having an excellent ion buffering performance in a lysosome pH condition, and an excellent effect on discharging genes to deliver into the cytoplasm. COPYRIGHT KIPO 2017 ...

Подробнее
19-05-2017 дата публикации

COMPOSITION FOR HYPERTHERMIA THERAPIES CONTAINING NANOPARTICLES

Номер: KR1020170055200A
Принадлежит:

The present invention relates to a nanoparticle exhibiting excellent effects in hyperthermia therapies, a method for producing the nanoparticle, a composition for hyperthermia therapies containing the nanoparticles, and a hyperthermia therapy method including the composition. According to the present invention, it is possible to kill tumor cells via hyperthermia therapies using the nanoparticles without causing toxicity on cells around tumor. Particularly, the nanoparticles can be used in a field of hyperthermia therapies without side effects, since the nanoparticles do not induce cytotoxicity. Additionally, containing a silica core and a gold surface layer, the nanoparticles can increase effects in antitumor therapies, since a temperature change due to the nanoparticles is significant through high light absorptiveness in a near-infrared ray region during the hyperthermia therapies. COPYRIGHT KIPO 2017 ...

Подробнее
24-07-2017 дата публикации

MAGNETIC RESONANCE IMAGING CONTRAST AGENT HAVING T1 AND T2 DUAL-FUNCTION

Номер: KR1020170085278A
Принадлежит:

The present invention relates to super paramagnetic-paramagnetic core-shell hybrid nanoparticles showing a magnetic resonance imaging effect of a T1 and T2 dual-function, and a production method thereof. The hybrid nanoparticles have a manganese oxide shell which is easily degraded in the intracellular environment and can be utilized as an MR contrast agent capable of enhancing an imaging target specific contrast effect by maximizing the T1 and T2 highlighting imaging effect through the decomposition of the shell. COPYRIGHT KIPO 2017 (AA) Super magnetic nanoparticle (BB) Surface growth of Mn_3O_4 (CC) Super magnetic core (DD) Paramagnetic Mn_3O_4 shell (EE) Coating of hydrophilic (amphiphilic) polymer ...

Подробнее
29-10-2015 дата публикации

MAGNETIC NANO-VECTOR FOR TRANSFERRING NUCLEIC ACIDS SPECIFIC TO LIVER CELL AND MAGNATIC RESONANCE IMAGING

Номер: KR0101563790B1
Принадлежит: 연세대학교 산학협력단

... 본 발명은 간세포 특이적 핵산 전달 및 자기공명영상용 자성 나노벡터에 관한 것으로서, 더욱 상세하게는 ASGPr(asialoglycoprotein receptor) 결합성 리간드와 결합하는 자성나노입자를 포함하는 자성 나노전달체 및 핵산 구조체를 포함하는 ASGPr 결합성 리간드-세포전달용 화합물의 복합 구조로 간세포에 선택적으로 흡수되어 핵산에 의한 형질 도입/변환이 가능한 벡터의 역할과 자기공명영상장치(MRI)를 이용한 간세포 특이성 평가가 동시에 가능한 자성 나노벡터에 관한 것이다.

Подробнее
11-09-2015 дата публикации

BIOMARKER-SPECIFIC AMPHIPHILIC NANOPARTICLE

Номер: WO2015133703A1
Принадлежит:

The present invention relates to a biomarker-specific amphiphilic nanoparticle. More specifically, the present invention provides an amphiphilic nanoparticle which can be used as a diagnostic or a therapeutic drug or gene carrier by selectively recognizing and then binding to a protease specifically expressed in a cell membrane of a certain cell, and thereby efficiently achieving endocytosis and selective degradation. The amphiphilic nanoparticle of the present invention can be used in diagnosis or treatment of diseases.

Подробнее
03-03-2016 дата публикации

METHOD FOR SEPARATING MULTIPLE BIOMATERIALS

Номер: WO2016032035A1
Принадлежит:

The present invention relates to a method for separating biomaterials using characteristics of magnetic nanoparticles. The method of the present invention employs a difference in magnetic susceptibility or magnetization depending on the composition of magnetic nanoparticles, and thus, magnetic particles are attached to biomaterials to be separated, and then several biomaterials can be separated from each other at the same time due to different traces in the external magnetic field with the same intensity.

Подробнее
01-07-2015 дата публикации

METHOD FOR IMPARTING HYDROPHILIC PROPERTY FOR MAGNETIC NANOPARTICLES

Номер: KR1020150073282A
Принадлежит:

The present invention relates to a method for imparting a hydrophilic property to magnetic nanoparticles. According to the present invention, a nano-emulsion is formed by mixing and stirring, and ultrasonic treating an organic solvent phase wherein unmodified magnetic nanoparticles are dispersed and a water phase wherein unmodified polysaccharides are dispersed, and an organic solvent inside the nano-emulsion is evaporated and removed. Through the above method, the unmodified magnetic nanoparticles is coated with the unmodified natural polysaccharide. Therefore, the present invention has an effect of imparting excellent water-dispersibility, in vivo stability, and targeting performances to hydrophobic magnetic nanoparticles. COPYRIGHT KIPO 2015 (A1) Organic solvent (A2) Organic solvent (BB) After polysaccharide coating ...

Подробнее
01-07-2015 дата публикации

METHOD FOR DETECTING BIOMOLECULE BY USING LOCALIZED SURFACE PLASMON RESONANCE

Номер: KR1020150073283A
Принадлежит:

The present application relates to a method for detecting a biomolecule by using localized surface plasmon resonance. According to the present application, it is possible to determine whether a biomolecule exists or not, and measure an expression amount and activity of a biomolecule by using localized surface plasmon resonances of a metal nanostructure, thereby diagnosing diseases related to the biomolecule. The method for detecting a biomolecule comprises the steps of: processing a metal nanostructure having peptide which is specifically decomposed by a biomolecule, with the biomolecule to be detected; and measuring a change in localized surface plasmon resonance of the metal nanostructure. COPYRIGHT KIPO 2015 (DD) Enzyme targeting (CC) Cell lysate processing (BB) Peptide fixing (AAPGNRs) PGNRs fixing (EE) Peptide decomposing (FF) Red movement (GG) Blue movement ...

Подробнее
26-09-2017 дата публикации

Tl 및 T2 이중 기능의 자기공명영상 조영제

Номер: KR0101779283B1
Принадлежит: 연세대학교 산학협력단

... 본 발명은 T1 및 T2 이중 기능의 자기공명영상 조영 효과를 보이는 초상자성-상자성 코어-쉘 혼성나노입자 및 이의 제조방법에 관한 것이다. 상기 혼성 나노입자는 세포 내 환경에서 쉽게 분해되는 산화망간 쉘을 가지며, 쉘의 분해를 통해 T1 및 T2 강조 영상 효과가 극대화 되는 특징을 통해 영상 표적 특이적 조영효과 증강이 가능한 MR 조영제로 활용 가능하다.

Подробнее
18-08-2017 дата публикации

BIOIMAGING PROBE FOR DETECTING INTRACELLULAR TARGET MOLECULES

Номер: KR101769244B1

The present invention relates to a bioimaging probe for detecting intracellular target molecules. According to the present invention, detection of target molecules in living cells can be conducted within a short amount of time, through development of novel polymeric nanoparticles capable of delivering intracellularly after supported with molecularbeacons. Accordingly, genetic assessment on cells can be carried out simply without killing cells in vitro, and target molecule detection in a single cell is possible as well. COPYRIGHT KIPO 2017 ...

Подробнее
09-07-2015 дата публикации

MAGNETIC NANO-VECTOR FOR TRANSFERRING NUCLEIC ACIDS SPECIFIC TO LIVER CELL AND MAGNETIC RESONANCE IMAGING

Номер: KR1020150080232A
Принадлежит:

The present invention relates to a magnetic nano-vector for transferring nucleic acids specific to liver cells and magnetic resonance imaging and, more specifically, to a magnetic nano-vector which performs simultaneously the function of a vector having a complex structure of the compound for transferring ASGPr-binding ligand-cell, which includes magnetic nano carrier having magnetic nanoparticles binding to asialoglycoprotein receptor (ASGPr)-binding ligands and a nucleic acid structure to be absorbed selectively by liver cells to perform the transfection and transformation by the nucleic acid; and the evaluation of the specificity to liver cells by using a magnetic resonance imaging device. COPYRIGHT KIPO 2015 ...

Подробнее
06-10-2015 дата публикации

ORGANIC NANOQUENCHER BASED ON CONJUGATED POLYMER AND PRODUCING METHOD THEREOF

Номер: KR1020150111400A
Принадлежит:

The present invention relates to an organic nanoquencher based on a conjugated polymer responding to an in vivo oxidation-reduction reaction and a producing method thereof. A pH responsive quencher according to the present invention can evaluate a metabolism environment according to a pH value in vivo with a characteristic that an absorption wavelength band sensitively changes depending on a pH condition. Therefore, it is used as a bioprobe which can effectively measure an early diagnosis and prognosis of a malignant tumor by easily and multiply detecting an in vivo oxidation-reduction reaction discovered in many of various metastatic cancers. COPYRIGHT KIPO 2016 ...

Подробнее
29-04-2016 дата публикации

Nanoparticle comprising hydrophobic drug conjugated to cationic polymer and hydrophilic drug conjugated to anionic polymer

Номер: KR0101616623B1
Принадлежит: 연세대학교 산학협력단

... 본 발명은 양이온성 고분자가 결합된 소수성 약물 및 음이온성 고분자가 결합된 친수성 약물을 포함하는 나노입자, 이의 제조방법 및 이의 약제학적 용도에 관한 것이다. 본 발명에 따른 나노입자는 친수성 약물과 소수성 약물을 동시에 전달할 수 있고, 약물의 초기 방출을 제어할 수 있다. 또한, 본 발명에 따른 나노입자는 암세포의 환경에 특이적이기 때문에, 암세포 선택적 진단 또는 치료가 가능하다.

Подробнее
28-08-2015 дата публикации

METHOD FOR MANUFACTURING MAGNETIC COMPOSITE FOR TREATING AND DIAGNOSING CANCER

Номер: KR1020150098515A
Принадлежит:

According to an embodiment of the present invention, a method of manufacturing a magnetic composite for treating and diagnosing cancer comprises a step of pyrolyzing precursors of magnetic nanoparticles under the presence of a conjugate polymer. The method for manufacturing a magnetic composite can produce the magnetic composite comprising magnetic nanoparticles coated with a conjugate polymer through a single process, thereby economically and efficiently producing the magnetic composite. COPYRIGHT KIPO 2015 ...

Подробнее
15-10-2015 дата публикации

Method of preparing for water soluble conductive polymer nanoparticle

Номер: KR0101559202B1
Принадлежит: 연세대학교 산학협력단

... 본 발명은 물 및 양친매성 고분자의 혼합물과 수성 용매 및 공액 고분자의 혼합물을 접촉시키는 것을 포함하는 수용성 공액 고분자 나노입자의 제조방법에 관한 것이다. 본 발명에 따르면 간단한 공정으로 입자 사이즈가 작고 균일하며, 콜로이드 안정성이 좋은 수용성 공액 고분자 나노입자를 제공할 수 있다.

Подробнее
04-02-2016 дата публикации

NANOPARTICLE COMPRISING HYDROPHOBIC DRUG BONDED TO CATIONIC POLYMER AND HYDROPHILIC DRUG BONDED TO ANIONIC POLYMER

Номер: KR1020160013342A
Принадлежит:

The present invention relates to a nanoparticle comprising a hydrophobic drug bonded to a cationic polymer and a hydrophilic drug bonded to an anionic polymer, to a manufacturing method thereof, and to pharmaceutical uses thereof. According to the present invention, the nanoparticle is capable of delivering a hydrophilic drug and a hydrophobic drug at the same time, and controlling initial release of the drug. In addition, according to the present invention, the nanoparticle is specific to environments of cancer cells, and is capable of selectively diagnosing or treating the cancer cells. COPYRIGHT KIPO 2016 ...

Подробнее
16-03-2017 дата публикации

MULTIPLE OPTICAL FUSION-IMAGE BASED METHOD AND APPARATUS FOR DIAGNOSING BRAIN TUMOR IN REAL-TIME

Номер: WO2017043839A2
Принадлежит:

A method and an apparatus for diagnosing a brain tumor in real-time are disclosed. A method for detecting a brain tumor in real-time can comprise the steps of: generating, by a probe, a plurality of input signals and transferring the same to a target detection region which is estimated to be the location of a brain tumor; receiving, by the probe, a plurality of reflection signals on the basis of a plurality of input signals; and detecting, by the probe, a plurality of the received reflection signals, wherein a plurality of the input signals comprise a terahertz signal, an optical coherence tomography (OCT) signal, and a Raman signal, and a plurality of the reflection signals can be used for generating a plurality of image information for detecting the location of a brain tumor; and an apparatus for diagnosing a brain tumor in vitro and in real-time, can be used to diagnose, in real-time, a brain tumor specimen, which is extracted from the brain.

Подробнее
18-05-2017 дата публикации

다중 생체물질의 분리방법

Номер: KR0101737695B1
Принадлежит: 연세대학교 산학협력단

... 본 발명은 자성 나노입자의 특성을 이용한 생체 물질을 분리하는 방법에 관한 것이다. 본 발명의 방법은 자성 나노입자의 조성에 따른 자기 민감도(susceptibility) 또는 자화도(magnetization) 차이를 이용하여 분리하려는 생체 물질에 자성 입자를 붙인 후 같은 세기의 외부 자기장에서 궤적의 차이로 여러 생체물질을 한번에 분리 가능한 효과를 나타낸다.

Подробнее
20-09-2018 дата публикации

SYSTEM FOR PREDICTING POST-SURGERY PROGNOSIS OR ANTICANCER DRUG COMPATIBILITY OF ADVANCED GASTRIC CANCER PATIENTS

Номер: WO2018169145A1
Принадлежит:

The present invention relates to a system for predicting a post-surgery prognosis or anticancer drug compatibility of advanced gastric cancer patients. An algorithm capable of predicting the prognosis and anticancer drug compatibility of advanced gastric cancer by using quantitative test results of the mRNA expression levels of a marker gene cluster and a reference gene cluster for the prognosis or anticancer drug compatibility thereof is developed so as to be usable as supplementary information for determining a treatment method for gastric cancer patients.

Подробнее
03-01-2018 дата публикации

유전자 전달체 및 그 제조방법

Номер: KR0101814879B1

... 본 발명은 체내 안정성이 현저히 우수하고, 표적부위 유전자 전달 효율이 우수한 유전자 전달체 및 이를 제조하는 방법에 관한 것이다. 본 발명의 유전자 전달체에 의하면 인지질 이중막을 통하여 세포 독성을 저하시키고, 세포 유입을 개선하였으며, in vivo 환경에서 효소 등에 의한 목적 유전자의 소실을 방지함으로써 유전자 전달 효율을 높이며, 리소좀 pH 조건에서 양이온성 고분자의 이온 완충 능력이 우수하여, 전달 유전자를 세포질 내로 방출시키는 효과가 우수하므로, 유전자 전달체 및 본 발명의 전달체를 이용한 유전자 치료에 효과적으로 사용할 수 있다.

Подробнее
06-02-2014 дата публикации

APTAMER SPECIFIC TO INTEGRIN ΑVΒ3 AND USE THEREOF

Номер: WO2014021630A1
Принадлежит:

The present invention relates to a DNA aptamer specifically binding to integrin αvβ3, and a composition for diagnosing cancer or metastasis of cancer including the aptamer as an active ingredient. Also, the present invention relates to a composition for imaging neoplastic diseases including the aptamer, and a contrast medium including same.

Подробнее
22-03-2017 дата публикации

METHOD AND APPARATUS FOR DIAGNOSING BRAIN TUMOR IN REAL TIME BASED ON MULTIPLE OPTICAL-FUSION IMAGE

Номер: KR1020170031813A
Принадлежит:

A method and an apparatus for diagnosing a brain tumor in real time are disclosed. The method for diagnosing a brain tumor in real time comprises the steps of: generating and sending, by a probe, a plurality of input signals to a target detection region which is estimated to be the brain tumor′s location; receiving, by the probe, a plurality of reflective signals based on the input signals; and detecting, by the probe, the received reflective signals. The input signals include a terahertz signal, an optical coherence tomography (OCT) signal, and a Raman signal. The reflective signals may be used for generating a plurality of pieces of image information for detecting the brain tumor location and may be used for real-time diagnosis of a brain tumor specimen extracted by an external real-time brain tumor diagnostic apparatus. COPYRIGHT KIPO 2017 (200) Power supply unit (210) Calculation unit (220) Storage unit (230) Input/output unit (240) THz generation unit and detection unit (250) Scan ...

Подробнее
24-02-2016 дата публикации

Organic Nanoquencher Based On Conjugated Polymer And Preparation Method Thereof

Номер: KR0101597023B1
Принадлежит: 연세대학교 산학협력단

... 본 발명은 생체 내 산화-환원 반응에 감응하는 공액고분자 기반 유기나노켄처 및 이의 제조방법에 관한 것이다. 본 발명에 따른 pH 감응형 켄처는 pH 상태에 따라 민감하게 흡수파장대가 변화하는 것을 특징으로 생체 내 pH 값에 따른 대사환경을 평가할 수 있다. 이에 따라, 다양한 전이암에 다수 발견되는 생체 내 산화-환원 반응에 대한 다중 검출이 용이해 짐으로써, 악성 종양의 조기 진단 및 예후를 효과적으로 판단할 수 있는 바이오프로브로 이용될 수 있다.

Подробнее
06-01-2016 дата публикации

METHOD FOR MANUFACTURING MAGNETIC HYBRID FOR TREATMENT AND DIAGNOSIS OF CANCER

Номер: KR0101582965B1
Принадлежит: 연세대학교 산학협력단

... 본 발명의 일 실시예에 따른 암 치료 및 진단용 자성복합체의 제조 방법은 공액 고분자 존재하에 자성 나노입자의 전구체를 열분해하는 단계를 포함한다. 상기 자성복합체의 제조 방법은 한 번의 공정으로 공액 고분자로 코팅된 자성 나노입자를 포함하는 자성복합체를 제조할 수 있어 자성복합체를 경제적이고 효율적으로 생산할 수 있다.

Подробнее
28-12-2016 дата публикации

COMPOSITE OF INORGANIC NANOPARTICLE AND CONDUCTIVE POLYMER USING AROMATIC COMPOUNDS

Номер: KR1020160149477A
Принадлежит:

The present invention relates to a composite of an inorganic nanoparticle and a conductive polymer using aromatic compounds, and to a production method thereof. More specifically, the present invention relates to a composite which can be applied to a diagnosis and treatment for cancer. Without the involvement of strong acid and a high temperature, it is possible to synthesize an inorganic nanoparticle and a conductive polymer, by reducing affinity among conductive polymers using aromatic compounds. The present invention further relates to a production method thereof. COPYRIGHT KIPO 2017 ...

Подробнее
06-01-2016 дата публикации

BIOENVIRONMENT-SENSITIVE NANOPARTICLE COMPRISING POLYMER WITH COMPLEMENTARY CHARGE

Номер: KR1020160000935A
Принадлежит:

The present invention relates to a bioenvironment-sensitive nanoparticle comprising a polymer with a complementary charge. The present invention further relates to a production method thereof and a pharmaceutical use thereof. According to the present invention, the nanoparticle stays in a stable state in an environment outside a cell. Thus, efficient and stable delivery of a target molecule such as a drug is possible even with a small quantity. Furthermore, the nanoparticle of the present invention tends to be specific in the cancer cell environment. Thus, the cancer cell-specific diagnosis or treatment is possible as well. COPYRIGHT KIPO 2016 (AA) (BB) (C1,C2) Hydrophilic polymer or polyamino acid (DD) Hydrophobic polymer or polyamino acid (EE) Hydrophilic polymer having a positive charger or polyamino acid (FF) Hydrophilic molecule having a negative charger (GG) Forming a ...

Подробнее
06-11-2017 дата публикации

다중 광학 융합영상 기반 실시간으로 뇌종양을 진단하는 방법 및 장치

Номер: KR0101793609B1
Принадлежит: 연세대학교 산학협력단

... 실시간으로 뇌종양을 진단하는 방법 및 장치가 개시된다. 실시간 뇌종양 검출 방법은 프로브가 복수의 입력 신호를 발생시켜 뇌종양의 위치로 추정되는 타겟 검출 영역으로 전달하는 단계, 프로브가 복수의 입력 신호에 기반한 복수의 반사 신호를 수신하는 단계와 프로브가 수신된 복수의 반사 신호를 검출하는 단계를 포함할 수 있되, 복수의 입력 신호는 테라헤르츠 신호, OCT(optical coherence tomography) 신호, 라만 신호를 포함하고, 복수의 반사 신호는 뇌종양의 위치를 검출하기 위한 복수의 영상 정보의 생성을 위해 사용될 수 있으며 체외 실시간 뇌종양 진단 장치를 통해 뇌로부터 적출된 뇌종양 검체의 실시간 진단을 위해 사용될 수 있다.

Подробнее
12-02-2016 дата публикации

Polyaniline coordinated with transition metal and preparation method thereof

Номер: KR0101593295B1
Принадлежит: 연세대학교 산학협력단

... 본 발명은 전이금속이 배위 결합된 폴리아닐린, 이를 코어로서 포함하는 코어쉘 구조의 나노입자 및 이들의 제조방법에 관한 것이다. 본 발명에 따른 전이금속이 배위 결합된 폴리아닐린 및 나노입자는 전이금속을 포함하는 코어쉘 구조의 산화제를 사용하여 제조할 수 있으며, 이렇게 제조된 폴리아닐린은 도핑된 상태로 제조되므로 제조공정이 간단할 뿐만 아니라, 용매에 대한 분산성이 향상되며, 폴리아닐린의 밴드갭 레벨 조절이 용이하다는 이점이 있다.

Подробнее
15-09-2015 дата публикации

POLYANILINE COORDINATE-BONDED WITH TRANSITION METAL AND MANUFACTURING METHOD THEREOF

Номер: KR1020150104258A
Принадлежит:

The present invention relates to polyaniline coordinate-bonded with a transition metal, a nanoparticle of a core shell structure comprising the same as a core, and a manufacturing method thereof. According to the present invention, polyaniline coordinate-bonded with a transition metal and a nanoparticle can be manufactured by using an oxidizing agent of a core shell structure comprising the transition metal. The polyaniline manufactured in a doped state has an advantage of easily controlling the level of a band gap of polyaniline, with a simple manufacturing process and improved dispersibility with respect to a solvent. COPYRIGHT KIPO 2015 ...

Подробнее
25-08-2016 дата публикации

PHOTOTHERMAL THERAPY TEMPERATURE CONTROL APPARATUS AND METHOD USING TERAHERTZ WAVES

Номер: KR1020160101227A
Принадлежит:

The present invention relates to a photothermal therapy temperature control apparatus and a method thereof using terahertz waves, which prevent overheating and can maintain a constant temperature in photothermal therapy using a laser, thereby allowing disease treatment at an optimal temperature. The photothermal therapy temperature control apparatus using terahertz waves comprises: an operation part applying a laser beam to a target tissue inoculated with photothermal particles; a measurement part transmitting and receiving terahertz waves on an affected part of the target tissue formed by the action of the operation part, and measuring the temperature of the affected part; and a temperature control part which is electrically connected to the operation part and the measurement part, compares the temperature of the affected part measured by the measurement part and a predetermined value, and maintains a constant temperature in order to maintain apoptosis temperature range for the target ...

Подробнее
27-08-2015 дата публикации

PREPARATION METHOD FOR MAGNETIC COMPOSITE FOR TREATING AND DIAGNOSING CANCER

Номер: WO2015126146A1
Принадлежит:

A preparation method for a magnetic composite for treating and diagnosing cancer, according to one embodiment of the present invention, comprises a step of pyrolyzing a precursor of a magnetic nanoparticle in the presence of a conjugated polymer. The preparation method for a magnetic composite can produce a magnetic composite economically and efficiently because a magnetic composite comprising a magnetic nanoparticle coated with a conjugated polymer can be prepared by a single process.

Подробнее
31-05-2017 дата публикации

나노입자를 포함하는 온열치료용 조성물

Номер: KR0101742884B1

... 본 발명은 본 발명은 온열치료에 우수한 효과를 가지는 나노입자, 상기 나노입자의 제조방법, 그리고 상기 나노입자를 포함하는 온열치료용 조성물 및 상기 조성물을 포함하는 온열치료 방법에 관한 것으로, 본 발명에 따르면, 종양 주변세포에 독성 없이, 본 발명의 나노입자에 의한 온열치료에 의하여 종양세포를 사멸시킬 수 있고, 특히 세포독성이 없어 부작용 없이 온열치료 분야에서 사용될 수 있다. 또한, 본 발명의 나노입자는 실리카 코어 및 금 표면층을 포함하고 있어, 근적외선 영역에서 높은 흡광력을 통해서 온열치료 시 나노입자에 의한 온도의 변화가 커서, 항암 치료의 효과를 높일 수 있다.

Подробнее
23-07-2015 дата публикации

BIOMARKER SPECIFIC AMPHIPHILIC NANOPARTICLE

Номер: KR101538268B1

The present invention relates to a biomarker specific amphiphilic nanoparticle, and more specifically, to an amphiphilic nanoparticle capable of being used as a diagnosis or treatment type drug or a gene delivery as an inflow in a cell and a selective decomposition are effectively done after selectively recognizing and combining a proteolytic enzyme which is specifically realized on a cell membrane of a certain cell. The amphiphilic nanoparticle is able to be used for a diagnosis or a treatment of a disease. The present invention includes: a hydrophilic polymer and hydrophobic polymer-containing block copolymer (A); and a peptide and hydrophilic polymer-containing block copolymer (B) dissolved by the proteolytic enzyme. COPYRIGHT KIPO 2015 (AA) Driving mechanism of an existing nano-delivery (BB) Driving mechanism of a nano-delivery of the present invention (C1,C2) Hydrophilic polymer or polyamino acid (D1,D2) Hydrophobic polymer or polyamino acid (EE) Spacer (FF) Target aiming particle ...

Подробнее
29-08-2016 дата публикации

테라헤르츠파를 이용한 광열치료 온도 제어 장치 및 그 제어 방법

Номер: KR0101651265B1
Принадлежит: 연세대학교 산학협력단

... 본 발명은 광열 입자가 주입된 대상 조직에 레이저 빔을 조사하는 작용부; 상기 작용부의 작용에 의한 상기 대상 조직의 작용 부위에 테라헤르츠파를 송수신하여 상기 작용 부위의 온도를 측정하는 측정부; 및 상기 작용부 및 상기 측정부와 전기적으로 연결되며, 상기 측정부로 측정된 상기 작용 부위의 온도를 설정값과 비교하여 상기 대상 조직의 세포사멸(apoptosis) 온도 범위를 유지할 수 있게 일정하게 유지시키는 온도 제어부를 포함하는 것을 특징으로 하여, 레이저를 이용한 광열치료에 있어서 과열을 방지하고 일정한 온도 유지가 가능하도록 하여 최적의 온도로 질환 치료가 가능하도록 하는 테라헤르츠파를 이용한 광열치료 온도 제어 장치 및 그 제어 방법에 관한 것이다.

Подробнее
07-03-2016 дата публикации

METHOD FOR ISOLATING MULTIPLE BIOMATERIALS

Номер: KR1020160024804A
Принадлежит:

The present invention relates to a method for isolating biomaterials using characteristics of magnetic nanoparticles which are represented by chemical formula 1. The method of the present invention uses the difference in magnetic susceptibility or magnetization depending on the composition of the magnetic nanoparticles, and thus, magnetic nanoparticles are attached to the biomaterials to be isolated, and then several biomaterials can be isolated from each other at the same time due to different traces in the external magnetic field with the same intensity. COPYRIGHT KIPO 2016 ...

Подробнее
09-10-2014 дата публикации

METHOD FOR MANUFACTURING GASTRIC CANCER PROGNOSIS PREDICTION MODEL

Номер: WO2014163445A1
Принадлежит:

The present invention relates to a novel model for predicting a prognosis capable of predicting the prognosis of gastric cancer, and more specifically, to manufacturing a prediction model for predicting a clinical result after a resection during gastric cancer surgery through genetic mutation comparative analysis.

Подробнее
25-07-2016 дата публикации

상보적인 전하를 가지는 고분자를 포함하는 생체환경 감응형 나노입자

Номер: KR0101642571B1
Принадлежит: 연세대학교 산학협력단

... 본 발명은 상보적인 전하를 가지는 고분자를 포함하는 생체환경 감응형 나노입자, 이의 제조방법 및 이의 약제학적 용도에 관한 것이다. 본 발명에 따른, 나노입자는 세포 밖 환경에서 안정하기 때문에, 적은 양으로도, 약물 등의 목적 물질을 안정하고 효율적으로 전달할 수 있다. 또한, 본 발명의 나노입자는 암세포의 환경에 특이적이기 때문에, 암세포 선택적 진단 또는 치료가 가능하다.

Подробнее
29-01-2015 дата публикации

PRODUCTION METHOD FOR WATER-SOLUBLE CONJUGATED POLYMER NANOPARTICLES

Номер: WO2015012455A1
Принадлежит:

The present invention relates to a production method for water-soluble conjugated polymer nanoparticles, the method comprising establishment of contact between: a mixture of water and an amphipathic polymer; and a mixture of an aqueous solvent and a conjugated polymer. The present invention makes it possible to use a straightforward process in order to provide water-soluble conjugated polymer nanoparticles having a small and uniform particle size and good colloidal stability.

Подробнее
10-05-2013 дата публикации

PROBE FOR DIAGNOSING OTITIS MEDIA USING TERAHERTZ WAVES AND OTITIS MEDIA DIAGNOSIS SYSTEM AND METHOD

Номер: WO2013066107A1
Принадлежит:

The present invention relates to a otitis media diagnosis system using terahertz waves, which can diagnose otitis media using terahertz waves in a non-invasive manner, and which can diagnose otitis media in an accurate manner by acquiring images on a tympanic cavity using terahertz waves having excellent transmittance, and which can discriminate between otitis media with effusion and suppurative otitis media in a quick and accurate manner using terahertz waves that are sensitive to moisture, and which is safe to a body using terahertz waves. The otitis media diagnosis system using terahertz waves according to the present invention comprises: a terahertz probe including a generating unit for radiating terahertz waves from the outside of an ear toward a tympanic cavity and a detection unit for detecting the reflected terahertz waves reflected from the tympanic cavity; a converting unit which converts the reflected terahertz waves detected by the detection unit into an electrical signal and ...

Подробнее
09-10-2014 дата публикации

SYSTEM FOR PREDICTING PROGNOSIS OF LOCALLY ADVANCED GASTRIC CANCER

Номер: WO2014163444A1
Принадлежит:

The present invention relates to a novel system for predicting a prognosis capable of predicting the prognosis of locally advanced gastric cancer, and more specifically, capable of predicting a clinical result after a resection during gastric cancer surgery through gene set enrichment comparative analysis.

Подробнее
02-03-2017 дата публикации

방향족 화합물을 활용한 전도성 고분자와 무기 나노입자의 복합체

Номер: KR0101711738B1
Принадлежит: 연세대학교 산학협력단

... 본 발명은 방향족 화합물을 활용한 전도성 고분자와 무기 나노입자의 복합체 및 이의 제조방법에 관한 것으로, 강한 산성 및 고온의 조건 없이도 방향족 화합물을 활용하여 전도성 고분자 간의 친화력을 줄임으로써 전도성 고분자와 무기 나노입자를 합성하여, 암 진단 및 치료에 효과적으로 활용 가능한 복합체 및 이의 제조방법에 관한 것이다.

Подробнее
02-02-2012 дата публикации

STIMULUS SENSITIVE MAGNETIC NANOCOMPOSITE USING PYRENE POLYMER, AND CONTRAST MEDIUM COMPOSITION CONTAINING THE NANOCOMPOSITE

Номер: KR2012015125A1
Принадлежит:

The present invention relates to a stimulus sensitive magnetic nanocomposite using a pyrene polymer, and a preparation method thereof, and more specifically, to a target specific stimulus sensitive magnetic nanocomposite comprising: an amphiphilic compound comprising one or more hydrophobic regions and one or more hydrophilic regions in which magnetic nanoparticles and a material having a pyrene structure are contained; and a pharmaceutically active ingredient, wherein the amphiphilic compound surrounds the pharmaceutically active ingredient, the pharmaceutically active ingredient surrounds the magnetic nanoparticles, and the pharmaceutically active ingredient is chemically bonded in the hydrophobic regions, thereby allowing the magnetic nanoparticles and the pharmaceutically active ingredient to show stable and excellent magnetic properties in an aqueous solution, enabling a rapid release behavior of a drug according to the specific stimulus, and enabling a target specificity by the tissue ...

Подробнее
08-07-2015 дата публикации

POLYMER HYDROGEL COMPLEX AND MANUFACTURING METHOD THEREOF

Номер: KR1020150077495A
Принадлежит:

The present invention relates to a polymer hydrogel complex and a manufacturing method thereof and, more specifically, to a polymer hydrogel complex for near-infrared ray area activation type imaging diagnosis, a manufacturing method thereof, and uses thereof, which comprises: anionic polysaccharide which is not reformed and can be targeting a biomarker; and a cationic polymer covalently bonded with a fluorescent material. COPYRIGHT KIPO 2015 (EE) 684nm emission (DD) 675nm adsorption (CC) Cancer stem cell film revealing CD 44 (BB) Optical image diagnosis of near-infrared rays area (AA) CD44 targeting (KK) Negative charge (JJ) Optical image diagnosis nano composite (NIRSH) activated in a near-infrared ray area (II) Positive charge (FF) Polyethyleneimine (PEI) (GG) Hyaluronic acid (HA) (HH) Cy5.5-PEI covalent bonding ...

Подробнее
16-03-2017 дата публикации

MULTIPLE OPTICAL FUSION-IMAGE BASED METHOD AND APPARATUS FOR DIAGNOSING BRAIN TUMOR IN REAL-TIME

Номер: WO2017043839A3
Принадлежит:

A method and an apparatus for diagnosing a brain tumor in real-time are disclosed. A method for detecting a brain tumor in real-time can comprise the steps of: generating, by a probe, a plurality of input signals and transferring the same to a target detection region which is estimated to be the location of a brain tumor; receiving, by the probe, a plurality of reflection signals on the basis of a plurality of input signals; and detecting, by the probe, a plurality of the received reflection signals, wherein a plurality of the input signals comprise a terahertz signal, an optical coherence tomography (OCT) signal, and a Raman signal, and a plurality of the reflection signals can be used for generating a plurality of image information for detecting the location of a brain tumor; and an apparatus for diagnosing a brain tumor in vitro and in real-time, can be used to diagnose, in real-time, a brain tumor specimen, which is extracted from the brain.

Подробнее
03-10-2013 дата публикации

PROGNOSIS PREDICTION SYSTEM OF LOCALLY ADVANCED GASTRIC CANCER

Номер: WO2013147330A1
Принадлежит:

The present invention relates to a novel prognosis prediction system capable of predicting a prognosis of a locally advanced gastric cancer. More specifically, the present invention can predict a clinical outcome through a comparative analysis method of gene or protein set expressions after surgically removing a gastric cancer.

Подробнее
01-11-2018 дата публикации

CLUSTER CLASSIFICATION AND PROGNOSIS PREDICTION SYSTEM BASED ON BIOLOGICAL CHARACTERISTICS OF GASTRIC CANCER

Номер: WO2018199589A1
Автор: HUH, Yong Min
Принадлежит:

The present invention relates to a cluster classification and prognosis prediction system based on the biological characteristics of gastric cancer, in which an algorithm for predicting a prognosis in terms of survival by using the result of a quantitative test of the mRNA expression level of a target gene cluster for prognosis of advanced gastric cancer is developed and can be used as auxiliary information in determining a treatment method for a gastric cancer patient.

Подробнее
01-10-2015 дата публикации

Polymer hydrogel complex and method for the preparation thereof

Номер: KR0101555764B1
Принадлежит: 연세대학교 산학협력단

... 본 발명은 고분자 하이드로겔 복합체 및 이의 제조방법에 관한 것으로, 더욱 상세하게는 바이오마커를 표적화 할 수 있고 개질되지 않은 음이온성 다당류 및 형광물질과 공유결합된 양이온성 고분자를 포함하는 근적외선 영역 활성화 영상진단용 고분자 하이드로겔 복합체, 이의 제조방법 및 이의 용도에 관한 것이다.

Подробнее