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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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26-05-2016 дата публикации

METHOD AND SYSTEM FOR POST-PROCESSING MEDICAL IMAGE IN RADIOLOGY AND DIGITAL IMAGE READING ENVIRONMENT

Номер: KR101624305B1
Автор: LEE, YOUNG HAN, SUH, JIN SUCK, KIM, MIN JUNG, YANG, JAE MOON
Принадлежит: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY

The present invention relates to a method and a system for post-processing a medical image in radiology and a digital image reading environment. The method and the system include: (a) a step in which a reading workstation requests for medical image information of a patient currently displayed in a DICOM viewer via a PACS; (b) a step in which the reading workstation receives the medical image information of the patient for post-processing a result from the PACS; (c) a step in which a storage module of the reading workstation encrypts the received medical image information and stores the information as a file; (d) a step in which an analysis module of the reading workstation decrypts the encrypted file and analyzes the decrypted medical image information; and (e) a step in which a processing module post-processes the medical image information analyzed by the analysis module. In this way, a file conversion module and the analysis module of the present invention provides the method and the ...

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Номер записи: 1
22-06-2017 дата публикации

난용성 약물의 서방형 제제

Номер: KR0101749425B1
Автор: 양재문, 서진석, 이영한, 허단
Принадлежит: 연세대학교 산학협력단

... 본 발명은 난용성 약물, 히알루론산 및 지방산을 포함하는 약제학적 조성물 및 이의 제조방법에 관한 것이다. 본 출원의 약제학적 조성물은 장기간 보관시에도 안정성이 우수하고 약물의 지속적인 방출이 가능하여 약물의 과용을 방지하고 환부의 치료 효율을 증대시키는 이점이 있다.

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Номер записи: 2
29-10-2015 дата публикации

MAGNETIC NANO-VECTOR FOR TRANSFERRING NUCLEIC ACIDS SPECIFIC TO LIVER CELL AND MAGNATIC RESONANCE IMAGING

Номер: KR0101563790B1
Автор: 양재문, 서진석, 허용민, 함승주, 박상욱, 허단
Принадлежит: 연세대학교 산학협력단

... 본 발명은 간세포 특이적 핵산 전달 및 자기공명영상용 자성 나노벡터에 관한 것으로서, 더욱 상세하게는 ASGPr(asialoglycoprotein receptor) 결합성 리간드와 결합하는 자성나노입자를 포함하는 자성 나노전달체 및 핵산 구조체를 포함하는 ASGPr 결합성 리간드-세포전달용 화합물의 복합 구조로 간세포에 선택적으로 흡수되어 핵산에 의한 형질 도입/변환이 가능한 벡터의 역할과 자기공명영상장치(MRI)를 이용한 간세포 특이성 평가가 동시에 가능한 자성 나노벡터에 관한 것이다.

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Номер записи: 3
16-08-2018 дата публикации

APPARATUS AND METHOD FOR DIAGNOSING MEDICAL CONDITION ON BASIS OF MEDICAL IMAGE

Номер: WO2018147674A1
Автор: LEE, Young-Han, HWANG, Do-Sik, SUH, Jin-Suck, YANG, Jae-Moon, KIM, Se-Won
Принадлежит:

Provided is a method for performing medical imaging diagnosis by a medical imaging diagnosis apparatus. A medical image is input to the medical imaging diagnosis apparatus. The medical imaging diagnosis apparatus performs a deep learning algorithm on the basis of the input medical image and a medical learning model for extracting a diagnostic part from the medical image, so as to extract a diagnostic part region from the medical image. The medical imaging diagnosis apparatus measures the distances between predetermined positions in the extracted diagnostic part region. In addition, the medical imaging diagnosis apparatus analyzes the distances measured for the diagnostic part region by comparing the same with a predetermined reference value, so as to generate and display the result of the medical imaging diagnosis.

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Номер записи: 4
11-09-2015 дата публикации

BIOMARKER-SPECIFIC AMPHIPHILIC NANOPARTICLE

Номер: WO2015133703A1
Автор: HAAM, Seungjoo, HUH, Yong-min, SUH, Jin-Suck, YANG, Jaemoon, KIM, Hyun-Ouk, CHOI, Jihye, JANG, Eunji, KANG, Byunghoon, NOH, Ilkoo, BAE, Seo Ryung
Принадлежит:

The present invention relates to a biomarker-specific amphiphilic nanoparticle. More specifically, the present invention provides an amphiphilic nanoparticle which can be used as a diagnostic or a therapeutic drug or gene carrier by selectively recognizing and then binding to a protease specifically expressed in a cell membrane of a certain cell, and thereby efficiently achieving endocytosis and selective degradation. The amphiphilic nanoparticle of the present invention can be used in diagnosis or treatment of diseases.

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Номер записи: 5
14-01-2019 дата публикации

수정된 딕슨 기법을 통해 획득한 자기 공명 영상을 이용한 암을 진단하기 위한 장치 및 이 방법을 수행하기 위한 프로그램이 기록된 컴퓨터 판독 가능한 기록매체

Номер: KR0101938048B1
Автор: 이영한, 서진석, 양재문, 이승현
Принадлежит: 연세대학교 산학협력단

... 본 발명은 수정된 딕슨 기법을 통해 획득한 자기 공명 영상을 이용한 암을 진단하기 위한 장치 및 이 방법을 수행하기 위한 프로그램이 기록된 컴퓨터 판독 가능한 기록매체를 제공한다. 이러한 본 발명은 마그넷 및 코일을 통해 검사 대상 주변에 자기장을 형성하고, 상기 자기장으로 인해 상기 검사 대상으로부터 발생하는 자기 공명 신호를 측정하는 측정부와, 상기 스캔부의 자기 공명 신호로부터 각각 물 이미지 및 지방 이미지를 포함하는 복수의 자기 공명 영상을 구성하고, 상기 구성된 자기 공명 영상에서 분석 영역을 지정한 후, 상기 물 이미지 및 지방 이미지를 이용하여 상기 분석 영역의 지방 분율을 산출하여, 상기 산출된 지방 분율에 따라 암을 진단하는 제어부를 포함하는 것을 특징으로 하는 자기 공명 영상을 이용한 암 진단 장치와, 이를 위한 방법 및 이 방법을 수행하기 위한 프로그램이 기록된 컴퓨터 판독 가능한 기록매체를 제공한다.

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Номер записи: 6
09-02-2018 дата публикации

IMAGING APPARATUS AND METHOD FOR MAGNETIC RESONANCE ARTHROGRAPHY AND RECORDING MEDIUM USING SAME

Номер: KR101828174B1
Автор: LEE, YOUNG HAN, SUH, JIN SUCK, YANG, JAE MOON, LEE, SEUNG HYUN
Принадлежит: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY

The present invention relates to an imaging apparatus and method for magnetic resonance arthrography and a recording medium using the same, which can obtain magnetic resonance images having clearer boundary according to portions within a joint and contrast optimized according to patients. The present invention provides the imaging apparatus for the magnetic resonance arthrography, comprising: an RF coil for measuring magnetic resonance (MR) signals; an imaging unit including an interest region setup module setting areas of interest at a plurality of portions, a time calculation module calculating a T1 value, a T2 value and a PD value of each of the areas of interest based on the MR signals measured by the RF coil, a signal strength calculation module calculating a signal strength at each of the areas of interest by using an equation, in which a repetition time (TR) and an echo time (TE) are included, based on the calculated T1, T2, and PD values, a difference calculation module calculating ...

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Номер записи: 7
20-08-2018 дата публикации

APPARATUS FOR DIAGNOSING STATUS BASED ON MEDICAL IMAGE AND METHOD THEREOF

Номер: KR1020180092797A
Автор: LEE, YOUNG HAN, HWANG, DO SIK, SUH, JIN SUCK, YANG, JAE MOON, KIM, SE WON
Принадлежит:

According to various embodiments of the present invention, an apparatus for diagnosing a cervical vertebral image comprises a prevertebral stripe region extracting unit having medical learning models for extracting a prevertebral stripe region in a cervical vertebral image and performing deep learning algorithm based on the inputted cervical vertebral image and the medical learning models to extract the prevertebral stripe region from the medical image; a measuring unit measuring a gap of the prevertebral stripe of a position set in the extracted prevertebral stripe region; and a diagnosis unit comparing and analyzing the measured prevertebral stripe gap with set reference values to generate and output a diagnosis result of the prevertebral stripe of the medical image. COPYRIGHT KIPO 2018 ...

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Номер записи: 8
06-04-2018 дата публикации

REDISPERSION METHOD OF NANO CONTRAST AGENT

Номер: KR1020180035721A
Автор: SUH JIN SUCK, YANG JAE MOON, LEE YOUNG HAN, HEO DAN
Принадлежит:

The present invention relates to a sugar-based redispersion method for making a drug substance of a nano-contrast agent. In the present invention, mannitol is added during lyophilization of the contrast agent to prevent entanglement between contrast agents when the contrast agent is dried, and a water-soluble redispersion property of the contrast agent can be increased through the high aqueous solubility of mannitol. COPYRIGHT KIPO 2018 ...

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Номер записи: 9
01-07-2015 дата публикации

METHOD FOR IMPARTING HYDROPHILIC PROPERTY FOR MAGNETIC NANOPARTICLES

Номер: KR1020150073282A
Автор: HAAM, SEUNG JOO, SUH, JIN SUCK, HUH, YONG MIN, YANG, JAE MOON, KIM, BONG JUNE
Принадлежит:

The present invention relates to a method for imparting a hydrophilic property to magnetic nanoparticles. According to the present invention, a nano-emulsion is formed by mixing and stirring, and ultrasonic treating an organic solvent phase wherein unmodified magnetic nanoparticles are dispersed and a water phase wherein unmodified polysaccharides are dispersed, and an organic solvent inside the nano-emulsion is evaporated and removed. Through the above method, the unmodified magnetic nanoparticles is coated with the unmodified natural polysaccharide. Therefore, the present invention has an effect of imparting excellent water-dispersibility, in vivo stability, and targeting performances to hydrophobic magnetic nanoparticles. COPYRIGHT KIPO 2015 (A1) Organic solvent (A2) Organic solvent (BB) After polysaccharide coating ...

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Номер записи: 10
01-07-2015 дата публикации

METHOD FOR DETECTING BIOMOLECULE BY USING LOCALIZED SURFACE PLASMON RESONANCE

Номер: KR1020150073283A
Автор: YANG, JAE MOON, SUH, JIN SUCK, HUH, YONG MIN, HAAM, SEUNG JOO, HONG, YOO CHAN
Принадлежит:

The present application relates to a method for detecting a biomolecule by using localized surface plasmon resonance. According to the present application, it is possible to determine whether a biomolecule exists or not, and measure an expression amount and activity of a biomolecule by using localized surface plasmon resonances of a metal nanostructure, thereby diagnosing diseases related to the biomolecule. The method for detecting a biomolecule comprises the steps of: processing a metal nanostructure having peptide which is specifically decomposed by a biomolecule, with the biomolecule to be detected; and measuring a change in localized surface plasmon resonance of the metal nanostructure. COPYRIGHT KIPO 2015 (DD) Enzyme targeting (CC) Cell lysate processing (BB) Peptide fixing (AAPGNRs) PGNRs fixing (EE) Peptide decomposing (FF) Red movement (GG) Blue movement ...

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Номер записи: 11
02-03-2016 дата публикации

CONJUGATED POLYMER NANOPARTICLE AND PRODUCTION METHOD THEREOF

Номер: KR1020160022621A
Автор: YANG, JAE MOON, KIM, JUNG HYUN, KIM, JEONG HUN, HONG, YOO CHAN, CHO, WON SEOK, HWANG, SEUNG YEON, SUH, JIN SUCK
Принадлежит:

The present invention relates to a conjugated polymer nanoparticle and a production method thereof, wherein the conjugated polymer nanoparticle comprises a conjugated polymer, fatty acids, and an amphipathic polymer. The conjugated polymer nanoparticle of the present invention can be doped in a neutral environment, and thus exhibits high electrical conductivity in the neutral environment such as in vivo. In addition, the nanoparticle has high light absorbance properties in a near infrared region. COPYRIGHT KIPO 2016 ...

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Номер записи: 12
09-07-2015 дата публикации

MAGNETIC NANO-VECTOR FOR TRANSFERRING NUCLEIC ACIDS SPECIFIC TO LIVER CELL AND MAGNETIC RESONANCE IMAGING

Номер: KR1020150080232A
Автор: YANG, JAE MOON, SUH, JIN SUCK, HUH, YONG MIN, HAAM, SEUNG JOO, PARK, SAHNG WOOK, HEO, DAN
Принадлежит:

The present invention relates to a magnetic nano-vector for transferring nucleic acids specific to liver cells and magnetic resonance imaging and, more specifically, to a magnetic nano-vector which performs simultaneously the function of a vector having a complex structure of the compound for transferring ASGPr-binding ligand-cell, which includes magnetic nano carrier having magnetic nanoparticles binding to asialoglycoprotein receptor (ASGPr)-binding ligands and a nucleic acid structure to be absorbed selectively by liver cells to perform the transfection and transformation by the nucleic acid; and the evaluation of the specificity to liver cells by using a magnetic resonance imaging device. COPYRIGHT KIPO 2015 ...

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Номер записи: 13
05-09-2017 дата публикации

암 진단 및 치료용 나노 프로브

Номер: KR0101775141B1
Автор: 양재문, 김은경, 서진석, 이유진, 김정훈, 홍유찬
Принадлежит: 연세대학교 산학협력단

... 본 발명은 암 진단 및 치료용 나노 프로브 에 관한 것으로서, 상기 암 진단 및 치료용 나노 프로브는 친수성 치환기로 치환된 공액 고분자를 포함하는 나노 입자, 그리고 상기 나노 입자 표면에 결합된 항체를 포함한다. 상기 암 진단 및 치료용 나노 프로브는 중성 환경에서도 자기 도핑되어, 생체 내에서와 같은 중성 환경에서도 전기 전도도가 높고, 근적외선 영역에서의 높은 흡광 특성을 가질 수 있어, 암세포 특이적 표적화가 가능하여 암세포 진단이 가능하고, 레이저 조사에 따른 광열 효과에 의하여 암세포의 특이적 치료도 가능하다.

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Номер записи: 14
03-01-2018 дата публикации

PROBE FOR LOCALIZED SURFACE PLASMON RESONANCE SENSOR FOR ION DETECTION, AND METHOD FOR DETECTING IONS AND SENSOR FOR DETECTING IONS USING SAME

Номер: KR1020180000589A
Автор: YANG, JAE MOON, HONG, YOO CHAN, PARK, JIN SUNG, JO, SEONG JAE
Принадлежит:

The present invention relates to a probe for a localized surface plasmon resonance sensor for ion detection, and to a method for detecting ions and a sensor for detecting ions using the same, wherein the probe includes a metal nanostructure and an ion chelator ion-bonded to the metal nanostructure and capable of coordinating to a target ion. The probe for a localized surface plasmon resonance sensor for ion detection can diagnose the possibility of cancer development and can diagnose the cancer in advance by measuring the amount and the change of trace amount of ions in the body which is a specific marker related to a microenvironment of a tumor, and uses a localized surface plasmon resonance signal to detect ions efficiently and with ultra-sensitivity. COPYRIGHT KIPO 2018 ...

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Номер записи: 15
06-04-2018 дата публикации

MAGNETIC RESONANCE IMAGING (MRI) CONTRAST AGENT FOR PRECISE DIAGNOSIS OF TUMOR, HAVING TARGET SPECIFICITY OF 1 NANOMOLE OR LESS, AND METHOD FOR PREPARING THEREOF

Номер: KR1020180035722A
Автор: YANG JAE MOON, SUH JIN SUCK, LEE YOUNG HAN, HEO DAN
Принадлежит:

The present invention relates to a magnetic resonance imaging (MRI) contrast agent for the precise diagnosis of tumor, having target specificity of 1 nmol or less, and to a method for preparing thereof. A cancer-specific target aptamer is conjugated to magnetic nanoparticles, which is a contrast agent for T2-weighted MRI, to provide target selectivity of 1 nmol or less, and thus the MRI contrast agent of the present invention can be used for the precise diagnosis of breast cancer and metastatic cancer expressing cancer specific biomarker. COPYRIGHT KIPO 2018 (AA) ErbB2 aptamer (BB) Fatty acid layer (CC) Iron oxide nanoparticles (DD) Amphipathic polymer layer ...

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Номер записи: 16
06-10-2015 дата публикации

ORGANIC NANOQUENCHER BASED ON CONJUGATED POLYMER AND PRODUCING METHOD THEREOF

Номер: KR1020150111400A
Автор: HAAM, SEUNG JOO, HUH, YONG MIN, YANG, JAE MOON, CHOI, JI HYE, CHOI, EUN BI, BAE, SEO RYUNG, BANG, DO YEON, KIM, HYUN OUK, LEE, TAEK SU
Принадлежит:

The present invention relates to an organic nanoquencher based on a conjugated polymer responding to an in vivo oxidation-reduction reaction and a producing method thereof. A pH responsive quencher according to the present invention can evaluate a metabolism environment according to a pH value in vivo with a characteristic that an absorption wavelength band sensitively changes depending on a pH condition. Therefore, it is used as a bioprobe which can effectively measure an early diagnosis and prognosis of a malignant tumor by easily and multiply detecting an in vivo oxidation-reduction reaction discovered in many of various metastatic cancers. COPYRIGHT KIPO 2016 ...

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Номер записи: 17
26-05-2017 дата публикации

SUSTAINED RELEASE FORMULATION OF POORLY SOLUBLE DRUG

Номер: KR1020170057884A
Автор: YANG, JAE MOON, SUH, JIN SUCK, LEE, YOUNG HAN, HEO, DAN
Принадлежит:

The present invention relates to a pharmaceutical composition comprising: a poorly soluble drug; hyaluronic acid; and fatty acids, and to a production method thereof. The pharmaceutical composition of the present invention has excellent stability even when stored for a long time, is capable of sustainedly releasing the drug, thereby preventing overdose of the drug and increasing treatment efficiency of an affected part. COPYRIGHT KIPO 2017 (AA) Immediately after completion of reaction (BB) 60 minutes after completion of reaction (C1,C2,C3) Third distilled water ...

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Номер записи: 18
07-05-2020 дата публикации

RAMAN SPECTROSCOPY SUBSTRATE AND APTASENSOR

Номер: WO2020091405A1
Автор: YANG, Jae-Moon, KIM, Jung-Hoon
Принадлежит:

The present invention relates to an inverse porous deposition film used for surface enhanced Raman spectroscopy, a method for manufacturing same, and a surface enhanced Raman spectroscopy substrate comprising same. The present invention relates to a Raman spectroscopy substrate, a method for manufacturing same, and an analysis device and analysis method comprising same. The present invention relates to an aptasensor comprising a substrate comprising a plurality of microgrooves, and a metal nanostructure fixed to a surface of the substrate.

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Номер записи: 19
28-08-2015 дата публикации

METHOD FOR MANUFACTURING MAGNETIC COMPOSITE FOR TREATING AND DIAGNOSING CANCER

Номер: KR1020150098515A
Автор: YANG, JAE MOON, SUH, JIN SUCK, HAAM, SEUNG JOO, LEE, EU GENE, HONG, YOO CHAN, KU, MIN HEE, HEO, DAN, HWANG, SEUNG YEONG, HUH, YONG MIN
Принадлежит:

According to an embodiment of the present invention, a method of manufacturing a magnetic composite for treating and diagnosing cancer comprises a step of pyrolyzing precursors of magnetic nanoparticles under the presence of a conjugate polymer. The method for manufacturing a magnetic composite can produce the magnetic composite comprising magnetic nanoparticles coated with a conjugate polymer through a single process, thereby economically and efficiently producing the magnetic composite. COPYRIGHT KIPO 2015 ...

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Номер записи: 20
15-10-2015 дата публикации

Method of preparing for water soluble conductive polymer nanoparticle

Номер: KR0101559202B1
Автор: 양재문, 서진석, 허용민, 함승주, 최지혜, 홍유찬, 이유진
Принадлежит: 연세대학교 산학협력단

... 본 발명은 물 및 양친매성 고분자의 혼합물과 수성 용매 및 공액 고분자의 혼합물을 접촉시키는 것을 포함하는 수용성 공액 고분자 나노입자의 제조방법에 관한 것이다. 본 발명에 따르면 간단한 공정으로 입자 사이즈가 작고 균일하며, 콜로이드 안정성이 좋은 수용성 공액 고분자 나노입자를 제공할 수 있다.

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Номер записи: 21
21-01-2019 дата публикации

EGFR 과발현 두경부암에서 EGFR 억제제 사용 후 EMT 관련 단백질이 증가하는 기전을 근거로 한 약물 저항성 극복을 위한 약학 조성물 및 약물 선택의 정보 제공 방법

Номер: KR1020190006695A
Автор: 양재문, 고윤우, 변형권, 양연주
Принадлежит:

... 본 발명은 EGFR 과발현 두경부암의 치료에 있어서 EGFR 억제제 투여 후 EMT 관련 단백질의 발현이 증가하는 기전을 근거로 하여 EGFR 억제제의 저항성을 극복하기 위한 약학 조성물 및 약물 선택을 위한 정보 제공 방법에 관한 것으로, 본 발명에 따르면 EGFR 억제제와 EMT 억제제를 병용 투여함으로써 EGFR 과발현 두경부암 치료 효과를 나타낼 수 있다.

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Номер записи: 22
26-05-2017 дата публикации

SUSTAINED-RELEASE PREPARATION OF POORLY SOLUBLE DRUG

Номер: WO2017086545A1
Автор: YANG, Jaemoon, SUH, Jin-Suck, LEE, Young Han, HEO, Dan
Принадлежит:

The present invention relates to a pharmaceutical composition containing a poorly soluble drug, hyaluronic acid, and a fatty acid, and to a method for preparing the same. The pharmaceutical composition of the present application has excellent stability even for long-term storage and allows a sustained release of the drug, thereby preventing an overdose of the drug and improving the therapeutic efficiency at an affected area.

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Номер записи: 23
14-07-2016 дата публикации

SKIN TEMPERATURE ALARMING SYSTEM IN FOCUSED ULTRASOUND SURGERY

Номер: KR101639016B1
Автор: LEE, YOUNG HAN, SUH, JIN SUCK, YANG, JAE MOON
Принадлежит: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY

The present invention relates to a novel focused ultrasound therapy system which is capable of easily detecting a temperature rise above the threshold near a target tissue. In order to perform focused ultrasound surgery which is non-invasive and promising, the system of the present invention prevents damage on peripheral tissues such as burn, by accurately detecting the temperature rise in real time without focusing on a monitor displaying much information at the same time during a complicated operational process. In addition, by adding a simple command to an existing program for magnetic-resonance-guided focused ultrasound surgery, the system can be easily produced and applied to procedures in the more safe and useful way. COPYRIGHT KIPO 2016 ...

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Номер записи: 24
16-03-2016 дата публикации

MAGNETIC RESONANCE IMAGE MARKER FOR FOCUSED ULTRASOUND SURGERY

Номер: KR101603742B1
Автор: LEE, YOUNG HAN, SUH, JIN SUCK, YANG, JAE MOON, HEO, DAN
Принадлежит: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY

The present invention relates to a magnetic resonance image marker plate for detecting a relative location of a target area in a body to be tested in a magnetic resonance image, and to a focused ultrasound treatment system including the same. The present invention provides rapid and reliable information about a lesion location as a target in various non-invasive treatments. Particularly, the magnetic resonance image marker plate can be applied to the focused ultrasound treatment system, enables a user to accurately and rapidly identify a treatment location with the minimum magnetic resonance image photographing and location adjustment. Therefore, the magnetic resonance image marker plate enables safe and efficient treatment, which does not require acquisition of an additional image or long-time anesthesia of a patient, to be performed. COPYRIGHT KIPO 2016 (A1,A2) Start to plan focused ultrasound treatment (B1,B2,B3) Obtain a magnetic resonance image before treatment (C1,C2) Start to anesthetize ...

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Номер записи: 25
04-11-2016 дата публикации

NANOPROBE FOR DIAGNOSIS AND TREATMENT OF CANCER

Номер: KR1020160127479A
Автор: YANG, JAE MOON, KIM, EUN KYOUNG, SUH, JIN SUCK, LEE, EU GENE, KIM, JEONG HUN, HONG, YOO CHAN
Принадлежит:

The present invention relates to a nanoprobe for the diagnosis and treatment of cancer. The nanoprobe for the diagnosis and treatment of cancer comprises: a nanoparticle including a conjugated polymer substituted with a hydrophilic substituent; and an antibody coupled to the surface of the nanoparticle. The nanoprobe for the diagnosis and treatment of cancer is self-doped even under neutral conditions, has high electric conductivity even under neutral conditions such as in vivo conditions, and can have high absorbance in a near-infrared region. Accordingly, the nanoprobe for the diagnosis and treatment of cancer can be targeted at a specific cancer cell, allows diagnosis of cancer, has a photothermal effect induced by laser application, and thus allows cancer cell-specific treatment. COPYRIGHT KIPO 2016 ...

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Номер записи: 26
30-01-2020 дата публикации

NANOPARTICLE FOR SENSING ACTIVATED OXYGEN AND METHOD FOR SENSING ACTIVATED OXYGEN USING SAME

Номер: WO2020022658A1
Автор: CHOI, Ji-Hye, YANG, Jae-Moon
Принадлежит:

The present invention relates to a nanoparticle for sensing activated oxygen, comprising a gold nanoparticle, a polyethylene glycol (PEG) attached to the surface of the gold nanoparticle, and a fluorescent substance attached to the polyethylene glycol; and a method for quantitatively sensing activated oxygen using same, which allows selective quantitative measurement of only activated oxygen generated by the gold nanoparticle.

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Номер записи: 27
07-06-2017 дата публикации

CANCER DIAGNOSING SYSTEM USING ULTRASOUND WAVES AND INFRARED RAYS

Номер: KR101744110B1
Автор: JUNG, DAE CHUL, YANG, JAE MOON, HONG, YOO CHAN, LEE, SEUNG SOO
Принадлежит: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY

The present invention relates to a cancer diagnosing system using ultrasonic waves and infrared rays. The cancer diagnosing system using ultrasound waves and infrared rays according to the present invention includes: a spectroscopic image collection module which collects a cross-sectional infrared spectroscopic image of a cancerous lesion in which cancer cells are located; an ultrasound image collection module which collects ultrasound images of the cancer lesion; an image reconstruction module which acquires a fusion image by combining the cross-sectional infrared spectroscopic image with the cross-sectional ultrasonic image; and a display device which displays the fusion image acquired by the image reconstruction module. Accordingly, the present invention can quickly, accurately, and safely diagnose prostate cancer. COPYRIGHT KIPO 2017 (110) Laser (120) Laser driving unit (130) Light detecting unit (140) Spectroscopic image processing unit (150) Spectroscopic image collection module control ...

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Номер записи: 28
24-02-2016 дата публикации

Organic Nanoquencher Based On Conjugated Polymer And Preparation Method Thereof

Номер: KR0101597023B1
Автор: 함승주, 허용민, 양재문, 최지혜, 최은비, 배서령, 방도연, 김현욱, 이택수
Принадлежит: 연세대학교 산학협력단

... 본 발명은 생체 내 산화-환원 반응에 감응하는 공액고분자 기반 유기나노켄처 및 이의 제조방법에 관한 것이다. 본 발명에 따른 pH 감응형 켄처는 pH 상태에 따라 민감하게 흡수파장대가 변화하는 것을 특징으로 생체 내 pH 값에 따른 대사환경을 평가할 수 있다. 이에 따라, 다양한 전이암에 다수 발견되는 생체 내 산화-환원 반응에 대한 다중 검출이 용이해 짐으로써, 악성 종양의 조기 진단 및 예후를 효과적으로 판단할 수 있는 바이오프로브로 이용될 수 있다.

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Номер записи: 29
04-07-2016 дата публикации

OPTICAL PROBE

Номер: KR0101635376B1
Автор: 양재문, 홍유찬, 이유진, 서진석, 함승주, 최지혜
Принадлежит: 연세대학교 산학협력단

... 본 발명의 일 실시예에 따른 광학 프로브는 다당류 및 공액 고분자를 포함한다. 상기 광학 프로브는 세포 독성이 강한 계면활성제를 사용하지 않고, 비색 결정법의 금속을 사용하지 않아 인체에 무해하다. 이러한 광학 프로브는 악성 종양에 표적화가 가능하고, 악성 종양의 진행 정도에 따라 다른 색을 나타내므로 높은 효율로 악성 종양의 정성 및 정량 분석이 가능하다. 또한, 상기 광학 프로브는 정상 세포에 손상을 주지 않고, 악성 종양 세포만을 광열 치료할 수 있다.

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Номер записи: 30
06-01-2016 дата публикации

METHOD FOR MANUFACTURING MAGNETIC HYBRID FOR TREATMENT AND DIAGNOSIS OF CANCER

Номер: KR0101582965B1
Автор: 양재문, 서진석, 함승주, 이유진, 홍유찬, 구민희, 허단, 황승연, 허용민
Принадлежит: 연세대학교 산학협력단

... 본 발명의 일 실시예에 따른 암 치료 및 진단용 자성복합체의 제조 방법은 공액 고분자 존재하에 자성 나노입자의 전구체를 열분해하는 단계를 포함한다. 상기 자성복합체의 제조 방법은 한 번의 공정으로 공액 고분자로 코팅된 자성 나노입자를 포함하는 자성복합체를 제조할 수 있어 자성복합체를 경제적이고 효율적으로 생산할 수 있다.

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Номер записи: 31
07-12-2015 дата публикации

POROUS NANOPARTICLE AND METHOD FOR PRODUCING POROUS NANOPARTICLE

Номер: KR1020150136296A
Автор: YANG, JAE MOON, SUH, JIN SUCK, HONG, YOO CHAN, HWANG, SEUNG YEONG, HAAM, SEUNG JOO, CHOI, JI HYE
Принадлежит:

The present invention relates to a porous nanoparticle, and a method for producing the porous nanoparticle. According to an embodiment of the present invention, the production method of the present invention can provide the porous nanoparticle which is composed of a pure conjugated polymer and maintains original characteristics of the conjugated polymer intact. COPYRIGHT KIPO 2016 ...

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Номер записи: 32
12-02-2016 дата публикации

Polyaniline coordinated with transition metal and preparation method thereof

Номер: KR0101593295B1
Автор: 함승주, 허용민, 양재문, 최지혜, 최은비, 배서령, 강병훈, 김명훈, 홍유찬, 김현욱
Принадлежит: 연세대학교 산학협력단

... 본 발명은 전이금속이 배위 결합된 폴리아닐린, 이를 코어로서 포함하는 코어쉘 구조의 나노입자 및 이들의 제조방법에 관한 것이다. 본 발명에 따른 전이금속이 배위 결합된 폴리아닐린 및 나노입자는 전이금속을 포함하는 코어쉘 구조의 산화제를 사용하여 제조할 수 있으며, 이렇게 제조된 폴리아닐린은 도핑된 상태로 제조되므로 제조공정이 간단할 뿐만 아니라, 용매에 대한 분산성이 향상되며, 폴리아닐린의 밴드갭 레벨 조절이 용이하다는 이점이 있다.

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Номер записи: 33
15-09-2015 дата публикации

POLYANILINE COORDINATE-BONDED WITH TRANSITION METAL AND MANUFACTURING METHOD THEREOF

Номер: KR1020150104258A
Автор: HAAM, SEUNG JOO, HUH, YONG MIN, YANG, JAE MOON, CHOI, JI HYE, CHOI, EUN BI, BAE, SEO RYUNG, KANG, BYUNG HOON, KIM, MYEONG HOON, HONG, YOO CHAN, KIM, HYUN OUK
Принадлежит:

The present invention relates to polyaniline coordinate-bonded with a transition metal, a nanoparticle of a core shell structure comprising the same as a core, and a manufacturing method thereof. According to the present invention, polyaniline coordinate-bonded with a transition metal and a nanoparticle can be manufactured by using an oxidizing agent of a core shell structure comprising the transition metal. The polyaniline manufactured in a doped state has an advantage of easily controlling the level of a band gap of polyaniline, with a simple manufacturing process and improved dispersibility with respect to a solvent. COPYRIGHT KIPO 2015 ...

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Номер записи: 34
27-08-2015 дата публикации

PREPARATION METHOD FOR MAGNETIC COMPOSITE FOR TREATING AND DIAGNOSING CANCER

Номер: WO2015126146A1
Автор: YANG, Jae Moon, SUH, Jin Suck, HAAM, Seung Joo, LEE, Eu Gene, HONG, Yoo Chan, KU, Min Hee, HEO, Dan, HWANG, Seung Yeon, HUH, Yong Min
Принадлежит:

A preparation method for a magnetic composite for treating and diagnosing cancer, according to one embodiment of the present invention, comprises a step of pyrolyzing a precursor of a magnetic nanoparticle in the presence of a conjugated polymer. The preparation method for a magnetic composite can produce a magnetic composite economically and efficiently because a magnetic composite comprising a magnetic nanoparticle coated with a conjugated polymer can be prepared by a single process.

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Номер записи: 35
13-07-2018 дата публикации

METHOD FOR PRODUCING STEM CELL CANCER STRAIN THROUGH METABOLIC STRESS AND CANCER STEM CELL PRODUCED BY METHOD

Номер: KR1020180080963A
Автор: YANG, JAE MOON, SUH, JIN SUCK, KU, MIN HEE
Принадлежит:

The present invention relates to a stem cell cancer strain and to a production method thereof, and more specifically, metabolic stress is applied to cancer cells to be induced into stem cell cancer cells. More specifically, the present invention relates to the production and establishment of the stem cell cancer strain by repeating culture in a glucose-deficient medium. The main features of the stem cell cancer strain produced by the method are that, in a glucose-deficient environment, the resistance to apoptosis is highly exhibited and the resistance to anticancer drugs is highly exhibited. COPYRIGHT KIPO 2018 ...

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Номер записи: 36
23-07-2015 дата публикации

BIOMARKER SPECIFIC AMPHIPHILIC NANOPARTICLE

Номер: KR101538268B1
Автор: HAAM, SEUNG JOO, HUH, YONG MIN, SUH, JIN SUCK, YANG, JAE MOON, KIM, HYUN OUK, CHOI, JI HYE, JANG, EUN JI, KANG, BYUNG HOON, NOH, IL KOO, BAE, SEO RYUNG
Принадлежит: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY

The present invention relates to a biomarker specific amphiphilic nanoparticle, and more specifically, to an amphiphilic nanoparticle capable of being used as a diagnosis or treatment type drug or a gene delivery as an inflow in a cell and a selective decomposition are effectively done after selectively recognizing and combining a proteolytic enzyme which is specifically realized on a cell membrane of a certain cell. The amphiphilic nanoparticle is able to be used for a diagnosis or a treatment of a disease. The present invention includes: a hydrophilic polymer and hydrophobic polymer-containing block copolymer (A); and a peptide and hydrophilic polymer-containing block copolymer (B) dissolved by the proteolytic enzyme. COPYRIGHT KIPO 2015 (AA) Driving mechanism of an existing nano-delivery (BB) Driving mechanism of a nano-delivery of the present invention (C1,C2) Hydrophilic polymer or polyamino acid (D1,D2) Hydrophobic polymer or polyamino acid (EE) Spacer (FF) Target aiming particle ...

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Номер записи: 37
03-12-2015 дата публикации

POROUS NANOPARTICLES AND PRODUCTION METHOD FOR POROUS NANOPARTICLES

Номер: WO2015182824A1
Автор: YANG, Jae Moon, SUH, Jin Suck, HONG, Yoo Chan, HWANG, Seung Yeon, ΗΑΑΜ, Seung Joo, CHOI, Ji Hye
Принадлежит:

The present invention relates to porous nanoparticles and a production method for porous nanoparticles. The production method for porous nanoparticles according to one embodiment can provide porous nanoparticles which are composed of pure conjugated polymers and which maintain the intrinsic characteristics of the conjugated polymers.

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Номер записи: 38
04-01-2019 дата публикации

대사적 스트레스를 통한 줄기세포성 암 세포주의 제조 방법 및 이를 통해 제조된 암 세포주

Номер: KR0101935513B1
Автор: 양재문, 서진석, 구민희
Принадлежит: 연세대학교 산학협력단

... 본 발명은 줄기세포성을 가지는 암 세포주 및 그 제조 방법에 관한 것으로, 보다 구체적으로는 암세포에 대사적 스트레스를 가함으로써 줄기세포성 암세포로 유도하는 것이며, 더욱 구체적으로는 글루코스 결피 배지에서의 배양을 반복함으로써 줄기세포성 암세포주 제조하고 확립하는 것에 관한 것이다. 상기 방법으로 제조된 줄기세포성 암 세포주의 주요 특징은 글루코스가 결핍된 환경에서 세포자멸자에 대한 저항능력이 높게 나타나고 항암제에 대한 저항성이 높게 나타난다.

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Номер записи: 39
19-09-2018 дата публикации

APPARATUS FOR DIAGNOSING CANCER USING MAGNETIC RESONANCE IMAGES OBTAINED THROUGH MODIFIED DIXON TECHNIQUE, METHOD THEREOF AND COMPUTER RECORDABLE MEDIUM STORING PROGRAM TO PERFORM METHOD

Номер: KR1020180103294A
Автор: LEE, YOUNG HAN, SUH, JIN SUCK, YANG, JAE MOON, LEE, SEUNG HYUN
Принадлежит:

The present invention provides an apparatus for diagnosing cancer using a magnetic resonance image obtained through a modified Dixon technique, a method thereof and a computer readable recording medium on which a program for performing the method is stored. The present invention comprises: a measuring unit that forms a magnetic field around an object to be inspected through a magnet and a coil and measures a magnetic resonance signal generated from the object by the magnetic field; and a control unit for constructing a plurality of magnetic resonance images each including a water image and a fat image from a magnetic resonance signal of a scanning unit, designating an analysis region in the configured magnetic resonance images and then calculating a fat fraction of the analysis region using the water image and the fat image, and diagnosing cancer according to the calculated fat fraction. COPYRIGHT KIPO 2018 (130) Input unit (140) Display unit (150) Control unit ...

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Номер записи: 40
03-04-2017 дата публикации

다공성 나노입자 및 다공성 나노입자의 제조 방법

Номер: KR0101722556B1
Автор: 양재문, 서진석, 홍유찬, 황승연, 함승주, 최지혜
Принадлежит: 연세대학교 산학협력단

... 본 발명은 다공성 나노입자 및 다공성 나노입자의 제조 방법에 관한 것이다. 일 실시예에 따른 다공성 나노입자의 제조 방법은 순수한 공액 고분자로 이루어지며, 공액 고분자의 본연의 특성을 그대로 유지하는 다공성 나노입자를 제공할 수 있다.

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Номер записи: 41
29-01-2015 дата публикации

PRODUCTION METHOD FOR WATER-SOLUBLE CONJUGATED POLYMER NANOPARTICLES

Номер: WO2015012455A1
Автор: YANG, Jae Moon, SUH, Jin Suck, HUH, Yong Min, HAAM, Seung Joo, CHOI, Ji Hye, HONG, Yoo Chan, LEE, Eu Gene
Принадлежит:

The present invention relates to a production method for water-soluble conjugated polymer nanoparticles, the method comprising establishment of contact between: a mixture of water and an amphipathic polymer; and a mixture of an aqueous solvent and a conjugated polymer. The present invention makes it possible to use a straightforward process in order to provide water-soluble conjugated polymer nanoparticles having a small and uniform particle size and good colloidal stability.

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Номер записи: 42
01-08-2018 дата публикации

이온 검출을 위한 국소 표면 플라즈몬 공명 센서용 프로브, 이를 이용한 이온 검출 방법 및 이온 검출 센서

Номер: KR0101884518B1
Автор: 양재문, 홍유찬, 박진성, 조성재
Принадлежит: 연세대학교 산학협력단, 고려대학교 산학협력단

... 본 발명은 이온 검출을 위한 국소 표면 플라즈몬 공명 센서용 프로브, 이를 이용한 이온 검출 방법 및 이온 검출 센서에 관한 것으로서, 상기 프로브는 금속 나노 구조체, 그리고 상기 금속 나노 구조체에 이온 결합되며, 검출 대상 이온에 배위결합할 수 있는 이온 킬레이터(ion chelator)를 포함한다. 상기 이온 검출을 위한 국소 표면 플라즈몬 공명 센서용 프로브는 종양의 미세 환경과 관련된 특이적 마커인 체내 미량의 이온의 함량 및 변화를 측정함으로써 암 발전 가능성 및 암 조기 진단이 가능하며, 상기 국소 표면 플라즈몬 공명 신호를 이용하여 이를 효율적이고 극초감도로 검지가 가능하다.

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Номер записи: 43
13-03-2018 дата публикации

SKEWERED MUSSEL DISH PREPARING METHOD AND SKEWERED MUSSEL DISH PREPARING APPARATUS USING SAME

Номер: KR101837895B1
Автор: YANG, JAE MOON
Принадлежит: YANG, JAE MOON

According to an embodiment of the present invention, a skewered mussel dish preparing method includes the steps of: cooking the edible parts of mussels covered in shells at a predetermined pressure for a predetermined period; removing the shells from the cooked mussels with a removal unit; washing the mussels having the shells removed therefrom with a washing unit; enabling a penetrating unit to penetrate one washed mussel conveyed thereby and penetrate multiple mussels aligned in series in a direction vertical through a skewer member to the conveying direction when the multiple washed mussels are aligned in series; enabling a drying unit to dry the multiple mussels penetrated for a predetermined period; enabling a fixing unit to convey the multiple dried mussels and to fix the mussels aligned in multiple columns by plaiting the skewer member in the conveying direction therethrough when the mussels are aligned in multiple columns; and enabling a freezing storage unit to freeze and store ...

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Номер записи: 44
02-02-2012 дата публикации

STIMULUS SENSITIVE MAGNETIC NANOCOMPOSITE USING PYRENE POLYMER, AND CONTRAST MEDIUM COMPOSITION CONTAINING THE NANOCOMPOSITE

Номер: KR2012015125A1
Автор: HAAM, Seung Joo, SUH, Jin Suck, HUH, Yong Min, YANG, Jae Moon, LIM, Eun Kyung
Принадлежит:

The present invention relates to a stimulus sensitive magnetic nanocomposite using a pyrene polymer, and a preparation method thereof, and more specifically, to a target specific stimulus sensitive magnetic nanocomposite comprising: an amphiphilic compound comprising one or more hydrophobic regions and one or more hydrophilic regions in which magnetic nanoparticles and a material having a pyrene structure are contained; and a pharmaceutically active ingredient, wherein the amphiphilic compound surrounds the pharmaceutically active ingredient, the pharmaceutically active ingredient surrounds the magnetic nanoparticles, and the pharmaceutically active ingredient is chemically bonded in the hydrophobic regions, thereby allowing the magnetic nanoparticles and the pharmaceutically active ingredient to show stable and excellent magnetic properties in an aqueous solution, enabling a rapid release behavior of a drug according to the specific stimulus, and enabling a target specificity by the tissue ...

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Номер записи: 45
05-07-2018 дата публикации

RADIO FREQUENCY COIL AND MEDICAL IMAGING DEVICE INCLUDING SAME

Номер: WO2018124834A1
Автор: LEE, Young-Han, KIM, Min-Jung, YANG, Jae-Moon, SUH, Jin-Suck
Принадлежит:

A medical radio frequency coil according to an embodiment of the present invention may comprise: a base substrate; and a radio coil unit having a first coil element which has a rectangular shape and is formed along an edge of the inner peripheral surface of the base substrate, and a second coil element which is formed at the inner side of the first coil element and has a shape of paired paddles connected to each other. Therefore, the present invention provides a radio frequency coil, which can minimize an image distortion due to a beam-hardening artifact effect, and a medical imaging device including the same.

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Номер записи: 46
25-02-2016 дата публикации

CONJUGATED POLYMER NANOPARTICLES AND MANUFACTURING METHOD THEREOF

Номер: WO2016027952A1
Автор: YANG, Jae Moon, KIM, Jung Hyun, KIM, Jeong Hun, HONG, Yoo Chan, CHO, Won Seok, HWANG, Seung Yeon, SUH, Jin Suck
Принадлежит:

The present invention relates to conjugated polymer nanoparticles and a manufacturing method thereof, wherein the conjugated polymer nanoparticles comprise conjugated polymer, fatty acid and amphipathic polymer. The conjugated polymer nanoparticles can be doped in a neutral environment, and thus have high electrical conductivity in a neutral environment such as in vivo, and are capable of having high light absorbance properties in a near infrared region.

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Номер записи: 47
08-07-2015 дата публикации

POLYMER HYDROGEL COMPLEX AND MANUFACTURING METHOD THEREOF

Номер: KR1020150077495A
Автор: YANG, JAE MOON, HUH, YONG MIN, SUH, JIN SUCK, CHEONG, JAE HO, PARK, EUN SUNG, HAAM, SEUNG JOO, KU, MIN HEE, PARK, JUNG MIN
Принадлежит:

The present invention relates to a polymer hydrogel complex and a manufacturing method thereof and, more specifically, to a polymer hydrogel complex for near-infrared ray area activation type imaging diagnosis, a manufacturing method thereof, and uses thereof, which comprises: anionic polysaccharide which is not reformed and can be targeting a biomarker; and a cationic polymer covalently bonded with a fluorescent material. COPYRIGHT KIPO 2015 (EE) 684nm emission (DD) 675nm adsorption (CC) Cancer stem cell film revealing CD 44 (BB) Optical image diagnosis of near-infrared rays area (AA) CD44 targeting (KK) Negative charge (JJ) Optical image diagnosis nano composite (NIRSH) activated in a near-infrared ray area (II) Positive charge (FF) Polyethyleneimine (PEI) (GG) Hyaluronic acid (HA) (HH) Cy5.5-PEI covalent bonding ...

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Номер записи: 48
08-12-2017 дата публикации

RADIO FREQUENCY COIL AND MEDICAL IMAGING DEVICE INCLUDING SAME

Номер: KR101806198B1
Автор: LEE, YOUNG HAN, KIM, MIN JUNG, YANG, JAE MOON, SUH, JIN SUCK
Принадлежит: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY

According to an embodiment of the present invention, a medical radio frequency coil comprises: a base substrate; and a radio coil part including a first coil component with a rectangular shape which is formed along an edge of an inner circumferential of the base substrate and a second coil component with a paired paddles shape connected with each other which is formed on an inner side of the first coil component. Therefore, image distortion due to a beam-hardening artifact can be minimized. COPYRIGHT KIPO 2017 ...

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Номер записи: 49
09-02-2017 дата публикации

IMMUNOLOGICAL PLASMONIC-BASED BIOMOLECULE DETECTION METHOD

Номер: KR101705457B1
Автор: YANG, JAE MOON, HONG, YOO CHAN, LEE, EU GENE, KU, MIN HEE, SUH, JIN SUCK
Принадлежит: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY

The present invention relates to a method of detecting a substrate using local surface plasmon resonance. According to the present invention, the existence, expression, and activity of a substrate is able to be measured using the plasmon resonance phenomenon of metal nanomarbles. In addition, it is possible to diagnose a disease associated with the substrate through measurement of such a substrate. COPYRIGHT KIPO 2017 ...

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Номер записи: 50
13-08-2018 дата публикации

KIT FOR DETECTING VIRUS

Номер: KR1020180090509A
Автор: YANG, JAE MOON, KU, MIN HEE, SUH, JIN SUCK
Принадлежит:

The present invention relates to a kit for detecting virus, a composition for virus detection, and virus detection method. The kit for detecting virus comprises: biomolecules; and a probe. The probe includes conjugated polymer nanoparticles. According to the present invention, virus can be detected with high efficiency at low cost in a short period of time. COPYRIGHT KIPO 2018 (AA) Probe (BB) Virus (CC) Metal nanostructure (DD) After reacting a probe ...

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Номер записи: 51
13-08-2018 дата публикации

KIT FOR DETECTING VIRUS

Номер: KR1020180090513A
Автор: YANG, JAE MOON, KU, MIN HEE, SUH, JIN SUCK
Принадлежит:

The present invention relates to a kit for detecting virus, a composition for virus detection, and virus detection method. The kit for detecting virus comprises: biomolecules; and a probe. The probe includes conjugated polymer nanoparticles. According to the present invention, virus can be detected with high efficiency at a low cost in a short time. COPYRIGHT KIPO 2018 (A1,A2) Probe (B1,B2) Virus (C1,C2) Indicator (D1,D2,D3) Before quenching (E1,E2) Fluorescence after quenching (F1,F2) After reacting a probe (GG) Conjugated polymer nanoparticles (HH) Before improved quenching (I1,I2) Fluorescence ...

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Номер записи: 52
04-07-2016 дата публикации

CONJUGATED POLYMER NANOPARTICLE AND METHOD FOR PREPARING THE SAME

Номер: KR0101635373B1
Автор: 양재문, 김중현, 김정훈, 홍유찬, 조원석, 황승연, 서진석
Принадлежит: 연세대학교 산학협력단

... 본 발명은 공액 고분자 나노 입자 및 이의 제조 방법에 관한 것으로서, 상기 공액 고분자 나노 입자는 공액 고분자, 지방산(fatty acid) 및 양친매성 고분자를 포함한다. 상기 공액 고분자 나노 입자는 중성 환경에서도 도핑될 수 있어, 생체 내에서와 같은 중성 환경에서도 전기전도도가 높고, 근적외선 영역에서의 높은 흡광 특성을 가질 수 있다.

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Номер записи: 53
13-12-2018 дата публикации

의료 영상에 기반하여 상태를 진단하는 장치 및 방법

Номер: KR0101929127B1
Автор: 이영한, 황도식, 서진석, 양재문, 김세원
Принадлежит: 연세대학교 산학협력단

... 본 발명의 다양한 실시예들에 따른 경추 영상 진단 장치는, 상기 경추 영상에서 경추 연조직(prevertebral stripe) 영역을 추출하기 위한 의료 학습 모델들을 구비하며, 입력된 상기 경추 영상 및 상기 의료 학습 모델에 기반하는 딥러닝 알고리즘을 수행하여 상기 의료 영상에서 경추 연조직 영역을 추출하는 경추 연조직 영역 추출부와, 추출된 상기 경추 연조직 영역에서 설정된 위치의 경추 연조직의 간격을 측정하는 측정부 및 측정된 상기 경추 연조직 간격을 설정된 기준값들과 비교 분석하여 의료 영상의 경추 연조직 진단 결과를 생성하여 출력하는 진단부를 포함할 수 있다.

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Номер записи: 54
08-03-2018 дата публикации

RADIO FREQUENCY COIL COMPRISING CONDUCTIVE PAINT

Номер: KR101836723B1
Автор: LEE, YOUNG HAN, KIM, MIN JUNG, YANG, JAE MOON, SUH, JIN SUCK
Принадлежит: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY

The present invention relates to a radio frequency (RF) coil including conductive paint on a bonding part and a magnetic resonance imaging system for mammography including the same, a positron tomography system for mammography and a magnetic resonance imaging/positron tomography system for mammography, and a magnetic resonance imaging/positron tomography integrated system for mammography. The radio frequency coil including conductive paint according to an embodiment of the present invention can reduce beam-hardening artifact compared with the case of using the radio frequency coil bonded to an existing solder part. It is possible to obtain a maximum signal-to-noise ratio. COPYRIGHT KIPO 2018 ...

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Номер записи: 55
25-10-2018 дата публикации

METHOD FOR PREPARING CANCER STEMNESS CELL LINE THROUGH METABOLIC STRESS, AND CANCER CELL PREPARED THROUGH SAME

Номер: WO2018194419A2
Автор: YANG, Jaemoon, SUH, Jin-Suck, KU, Minhee
Принадлежит:

The present invention relates to a cancer cell line having stemness, and a method for preparing the same, more particularly, to inducing a cancer cell into a stemness cancer cell by applying metabolic stress to the cancer cell, and even more particularly, to preparing and establishing a cancer stemness cell line through repeated culturing in a glucose-deficient culture medium. The main characteristics of the cancer stemness cell line prepared by the method are high resistance to apoptosis in glucose-deficient environment and high resistance to anticancer agents.

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Номер записи: 56
17-01-2019 дата публикации

METHOD FOR PREPARING CANCER STEMNESS CELL LINE THROUGH METABOLIC STRESS, AND CANCER CELL PREPARED THROUGH SAME

Номер: WO2018194419A3
Автор: YANG, Jaemoon, SUH, Jin-Suck, KU, Minhee
Принадлежит:

The present invention relates to a cancer cell line having stemness, and a method for preparing the same, more particularly, to inducing a cancer cell into a stemness cancer cell by applying metabolic stress to the cancer cell, and even more particularly, to preparing and establishing a cancer stemness cell line through repeated culturing in a glucose-deficient culture medium. The main characteristics of the cancer stemness cell line prepared by the method are high resistance to apoptosis in glucose-deficient environment and high resistance to anticancer agents.

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Номер записи: 57
07-06-2018 дата публикации

국소표면 플라즈몬 공명을 이용한 생체분자 검출 방법

Номер: KR0101865428B1
Автор: 양재문, 서진석, 홍유찬
Принадлежит: 연세대학교 산학협력단

... 본 출원은 국소표면 플라즈몬 공명을 이용한 생체분자의 검출 방법에 관한 것이다. 본 출원에 따르면 금속 나노구조체의 국소표면 플라즈몬 공명 현상을 이용하여 생체 분자의 존재유무, 발현량 및 활성을 측정할 수 있다. 또한, 이러한 생체분자의 측정을 통하여 상기 생체분자와 관련된 질병을 진단할 수 있다.

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Номер записи: 58
01-10-2015 дата публикации

Polymer hydrogel complex and method for the preparation thereof

Номер: KR0101555764B1
Автор: 양재문, 허용민, 서진석, 정재호, 박은성, 함승주, 구민희, 박정민
Принадлежит: 연세대학교 산학협력단

... 본 발명은 고분자 하이드로겔 복합체 및 이의 제조방법에 관한 것으로, 더욱 상세하게는 바이오마커를 표적화 할 수 있고 개질되지 않은 음이온성 다당류 및 형광물질과 공유결합된 양이온성 고분자를 포함하는 근적외선 영역 활성화 영상진단용 고분자 하이드로겔 복합체, 이의 제조방법 및 이의 용도에 관한 것이다.

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Номер записи: 59
07-12-2015 дата публикации

OPTICAL PROBE

Номер: KR1020150136293A
Автор: YANG, JAE MOON, HONG, YOO CHAN, LEE, EU GENE, SUH, JIN SUCK, HAAM, SEUNG JOO, CHOI, JI HYE
Принадлежит:

According to an embodiment of the present invention, an optical probe comprises polysaccharides and a conjugated polymer. The optical probe is harmless to the human body, without using a surfactant which has strong cytotoxicity, and without using a metal of a method for colorimetric determination. The optical probe is capable of targeting a malignant tumor, and qualitatively and quantitatively analyzing the malignant tumor with high efficiency by representing a different color with respect to the degree of malignant tumor progression. In addition, the optical probe can perform light and heat treatment only of malignant tumor, without damage to normal cells. COPYRIGHT KIPO 2016 ...

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Номер записи: 60