Настройки

Укажите год
-

Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

Подробнее
-

Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

Подробнее

Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
Ведите корректный номера.
Ведите корректный номера.
Ведите корректный номера.
Ведите корректный номера.
Укажите год
Укажите год
Применить Всего найдено 82. Отображено 82.
19-05-2017 дата публикации

GENE CARRIER AND PREPARING METHOD THEREOF

Номер: KR1020170055201A
Автор: HAAM, SEUNG JOO, HUH, YONG MIN, JANG, EUN JI, HAN, SEUNG MIN, LEE, HWUN JAE
Принадлежит:

The present invention relates to a gene carrier which has an excellent gene delivery efficiency to a target region and extremely superior in vivo stability, and a preparing method thereof. According to the present invention, the gene carrier reduces cytotoxicity using a phospholipid double membrane, and has improved cell introduction. Also, the loss of target genes due to enzymes in an in vivo environment is prevented to improve gene delivery efficiency. A positive ionic polymer can be effectively used for the gene carrier and a gene treatment using the carrier of the present invention, by having an excellent ion buffering performance in a lysosome pH condition, and an excellent effect on discharging genes to deliver into the cytoplasm. COPYRIGHT KIPO 2017 ...

Подробнее
Номер записи: 1
19-05-2017 дата публикации

COMPOSITION FOR HYPERTHERMIA THERAPIES CONTAINING NANOPARTICLES

Номер: KR1020170055200A
Автор: HUH, YONG MIN, HAAM, SEUNG JOO, LEE, SANG WHA, PARK, SANG EUN, LEE, JAE WON, LEE, TAEK SU, BAE, SAET BYEOL, CHOI, DONG WOONG, KANG, BYUNG HOON
Принадлежит:

The present invention relates to a nanoparticle exhibiting excellent effects in hyperthermia therapies, a method for producing the nanoparticle, a composition for hyperthermia therapies containing the nanoparticles, and a hyperthermia therapy method including the composition. According to the present invention, it is possible to kill tumor cells via hyperthermia therapies using the nanoparticles without causing toxicity on cells around tumor. Particularly, the nanoparticles can be used in a field of hyperthermia therapies without side effects, since the nanoparticles do not induce cytotoxicity. Additionally, containing a silica core and a gold surface layer, the nanoparticles can increase effects in antitumor therapies, since a temperature change due to the nanoparticles is significant through high light absorptiveness in a near-infrared ray region during the hyperthermia therapies. COPYRIGHT KIPO 2017 ...

Подробнее
Номер записи: 2
02-09-2010 дата публикации

DEVICE FOR MEASURING DEFORMATION OF STRUCTURES AND A DEFORMATION-MEASURING METHOD FOR STRUCTURES EMPLOYING THE SAME

Номер: KR2010098647A2
Автор: HAAM, Seung Joo, LIM, Yun Mook, LIM, Yoon Cheol, PARK, JoSeph
Принадлежит:

The present invention relates to a device for measuring deformation ratios of structures and to a deformation-ratio-measuring method for structures employing the same. More specifically, the device for measuring deformation ratios of structures of the present invention comprises a photonic crystal layer containing nanoparticles disposed at predetermined intervals. According to the present invention, when diverse industrial structures deform due to factors such as loading in use, structural colour changes or magnetic changes in the affected portion are measured such that accurate measurements can be taken of whether or not deformation has occurred and of the deformation ratio in a way which is straightforward and easy, and these measurements can be used to prevent safety incidents from occurring due to excessive deformation of structures.

Подробнее
Номер записи: 3
24-07-2017 дата публикации

MAGNETIC RESONANCE IMAGING CONTRAST AGENT HAVING T1 AND T2 DUAL-FUNCTION

Номер: KR1020170085278A
Автор: HAAM, SEUNG JOO, HUH, YONG MIN, KIM, MYEONG HOON, SON, HYE YOUNG, KIM, GA YUN
Принадлежит:

The present invention relates to super paramagnetic-paramagnetic core-shell hybrid nanoparticles showing a magnetic resonance imaging effect of a T1 and T2 dual-function, and a production method thereof. The hybrid nanoparticles have a manganese oxide shell which is easily degraded in the intracellular environment and can be utilized as an MR contrast agent capable of enhancing an imaging target specific contrast effect by maximizing the T1 and T2 highlighting imaging effect through the decomposition of the shell. COPYRIGHT KIPO 2017 (AA) Super magnetic nanoparticle (BB) Surface growth of Mn_3O_4 (CC) Super magnetic core (DD) Paramagnetic Mn_3O_4 shell (EE) Coating of hydrophilic (amphiphilic) polymer ...

Подробнее
Номер записи: 4
29-10-2015 дата публикации

MAGNETIC NANO-VECTOR FOR TRANSFERRING NUCLEIC ACIDS SPECIFIC TO LIVER CELL AND MAGNATIC RESONANCE IMAGING

Номер: KR0101563790B1
Автор: 양재문, 서진석, 허용민, 함승주, 박상욱, 허단
Принадлежит: 연세대학교 산학협력단

... 본 발명은 간세포 특이적 핵산 전달 및 자기공명영상용 자성 나노벡터에 관한 것으로서, 더욱 상세하게는 ASGPr(asialoglycoprotein receptor) 결합성 리간드와 결합하는 자성나노입자를 포함하는 자성 나노전달체 및 핵산 구조체를 포함하는 ASGPr 결합성 리간드-세포전달용 화합물의 복합 구조로 간세포에 선택적으로 흡수되어 핵산에 의한 형질 도입/변환이 가능한 벡터의 역할과 자기공명영상장치(MRI)를 이용한 간세포 특이성 평가가 동시에 가능한 자성 나노벡터에 관한 것이다.

Подробнее
Номер записи: 5
11-09-2015 дата публикации

BIOMARKER-SPECIFIC AMPHIPHILIC NANOPARTICLE

Номер: WO2015133703A1
Автор: HAAM, Seungjoo, HUH, Yong-min, SUH, Jin-Suck, YANG, Jaemoon, KIM, Hyun-Ouk, CHOI, Jihye, JANG, Eunji, KANG, Byunghoon, NOH, Ilkoo, BAE, Seo Ryung
Принадлежит:

The present invention relates to a biomarker-specific amphiphilic nanoparticle. More specifically, the present invention provides an amphiphilic nanoparticle which can be used as a diagnostic or a therapeutic drug or gene carrier by selectively recognizing and then binding to a protease specifically expressed in a cell membrane of a certain cell, and thereby efficiently achieving endocytosis and selective degradation. The amphiphilic nanoparticle of the present invention can be used in diagnosis or treatment of diseases.

Подробнее
Номер записи: 6
03-03-2016 дата публикации

METHOD FOR SEPARATING MULTIPLE BIOMATERIALS

Номер: WO2016032035A1
Автор: HAAM, Seungjoo, HUH, Yong-min, KANG, Byunghoon, JANG, Eunji, HAN, Seungmin, KIM, Hyun-Ouk
Принадлежит:

The present invention relates to a method for separating biomaterials using characteristics of magnetic nanoparticles. The method of the present invention employs a difference in magnetic susceptibility or magnetization depending on the composition of magnetic nanoparticles, and thus, magnetic particles are attached to biomaterials to be separated, and then several biomaterials can be separated from each other at the same time due to different traces in the external magnetic field with the same intensity.

Подробнее
Номер записи: 7
26-10-2017 дата публикации

바이러스 검출용 키트

Номер: KR0101790088B1
Автор: 함승주, 김현욱, 김지혜, 송대섭
Принадлежит: 주식회사 휴벳바이오, 한국생명공학연구원

... 본 발명은 바이러스 검출용 키트, 바이러스검출용 조성물 및 바이러스 검출방법에 관한 것이다. 본 발명에 따르면, 저가의 비용으로 바이러스 바이러스를 단시간 내에 고효율로 검출할 수 있고, 민감도 및 정확도가 더욱 향상된 키트를 제조 할 수 있다.

Подробнее
Номер записи: 8
30-08-2017 дата публикации

MOLECULAR BEACON WITH REVERSE-HAIRPIN STRUCTURE AND METHOD FOR DETECTING TARGET MOLECULE BY USING SAME

Номер: KR101769239B1
Автор: HAAM, SEUNG JOO, KI, JI SUN, JANG, EUN JI, LEE, TACK SU
Принадлежит: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY

The present invention relates to a molecular beacon with a reverse-hairpin structure and a method for detecting a target molecule by using the same. More specifically, when a target molecule does not exist, a target sensing strand and a signal generating strand form a reverse-hairpin structure and are mixed. When the target molecule exists, the target molecule is mixed with the target sensing strand and the signal generating strand is separated from the target sensing strand and autonomously forms a hairpin structure. A target molecule can be detected by detecting a fluorescent elimination effect of a signal material bound to the signal generating strand and signal change in accordance with structural change of the signal generating strand. In addition, the signal generating strand, having generated the hairpin structure, forms the reverse-hairpin structure by mixing of a new target sensing strand and the signal generating strand. Accordingly, the molecular beacon can be reused to detect ...

Подробнее
Номер записи: 9
01-07-2015 дата публикации

METHOD FOR IMPARTING HYDROPHILIC PROPERTY FOR MAGNETIC NANOPARTICLES

Номер: KR1020150073282A
Автор: HAAM, SEUNG JOO, SUH, JIN SUCK, HUH, YONG MIN, YANG, JAE MOON, KIM, BONG JUNE
Принадлежит:

The present invention relates to a method for imparting a hydrophilic property to magnetic nanoparticles. According to the present invention, a nano-emulsion is formed by mixing and stirring, and ultrasonic treating an organic solvent phase wherein unmodified magnetic nanoparticles are dispersed and a water phase wherein unmodified polysaccharides are dispersed, and an organic solvent inside the nano-emulsion is evaporated and removed. Through the above method, the unmodified magnetic nanoparticles is coated with the unmodified natural polysaccharide. Therefore, the present invention has an effect of imparting excellent water-dispersibility, in vivo stability, and targeting performances to hydrophobic magnetic nanoparticles. COPYRIGHT KIPO 2015 (A1) Organic solvent (A2) Organic solvent (BB) After polysaccharide coating ...

Подробнее
Номер записи: 10
20-04-2018 дата публикации

스쿠알렌을 포함하는 양친매성 폴리 아미노산 고분자 기반 백신 면역보조제 조성물

Номер: KR0101850417B1
Автор: 함승주, 임종우, 김현욱, 최지혜, 윤다연, 김지혜, 송대섭, 염민주, 나운성
Принадлежит: 주식회사 휴벳바이오

... 본 발명은 양친매성 폴리 아미노산 고분자를 함유하는 수중유 에멀젼 상태의 양친매성 고분자 입자를 포함하는 면역보조제 조성물 및 이의 제조방법에 관한 것이다. 본 발명의 면역보조제 조성물은 양친매성 폴리 아미노산 고분자를 이용함으로써 더욱 생체 적합하고, 높은 항체 역가를 갖는 백신 면역보조제 조성물을 제공할 수 있다.

Подробнее
Номер записи: 11
01-07-2015 дата публикации

METHOD FOR DETECTING BIOMOLECULE BY USING LOCALIZED SURFACE PLASMON RESONANCE

Номер: KR1020150073283A
Автор: YANG, JAE MOON, SUH, JIN SUCK, HUH, YONG MIN, HAAM, SEUNG JOO, HONG, YOO CHAN
Принадлежит:

The present application relates to a method for detecting a biomolecule by using localized surface plasmon resonance. According to the present application, it is possible to determine whether a biomolecule exists or not, and measure an expression amount and activity of a biomolecule by using localized surface plasmon resonances of a metal nanostructure, thereby diagnosing diseases related to the biomolecule. The method for detecting a biomolecule comprises the steps of: processing a metal nanostructure having peptide which is specifically decomposed by a biomolecule, with the biomolecule to be detected; and measuring a change in localized surface plasmon resonance of the metal nanostructure. COPYRIGHT KIPO 2015 (DD) Enzyme targeting (CC) Cell lysate processing (BB) Peptide fixing (AAPGNRs) PGNRs fixing (EE) Peptide decomposing (FF) Red movement (GG) Blue movement ...

Подробнее
Номер записи: 12
14-07-2016 дата публикации

KIT FOR DETECTING VIRUS

Номер: WO2016111572A1
Автор: HAAM, Seungjoo, KIM, Hyun-Ouk, KIM, Jihye, SONG, Daesub
Принадлежит:

The present invention relates to a kit for detecting a virus, a composition for detecting a virus, and a method for detecting a virus. According to the present invention, a virus may be detected at a low cost, in a short time, and with high efficiency, and a kit having a more improved sensitivity and accuracy may be prepared.

Подробнее
Номер записи: 13
26-09-2017 дата публикации

Ｔｌ 및 Ｔ２ 이중 기능의 자기공명영상 조영제

Номер: KR0101779283B1
Автор: 함승주, 허용민, 김명훈, 손혜영, 김가윤
Принадлежит: 연세대학교 산학협력단

... 본 발명은 T1 및 T2 이중 기능의 자기공명영상 조영 효과를 보이는 초상자성-상자성 코어-쉘 혼성나노입자 및 이의 제조방법에 관한 것이다. 상기 혼성 나노입자는 세포 내 환경에서 쉽게 분해되는 산화망간 쉘을 가지며, 쉘의 분해를 통해 T1 및 T2 강조 영상 효과가 극대화 되는 특징을 통해 영상 표적 특이적 조영효과 증강이 가능한 MR 조영제로 활용 가능하다.

Подробнее
Номер записи: 14
18-08-2017 дата публикации

BIOIMAGING PROBE FOR DETECTING INTRACELLULAR TARGET MOLECULES

Номер: KR101769244B1
Автор: HAAM, SEUNG JOO, HUH, YONG MIN, HAN, SEUNG MIN, JANG, EUN JI, KANG, BYUNG HOON, KI, JI SUN
Принадлежит: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY

The present invention relates to a bioimaging probe for detecting intracellular target molecules. According to the present invention, detection of target molecules in living cells can be conducted within a short amount of time, through development of novel polymeric nanoparticles capable of delivering intracellularly after supported with molecularbeacons. Accordingly, genetic assessment on cells can be carried out simply without killing cells in vitro, and target molecule detection in a single cell is possible as well. COPYRIGHT KIPO 2017 ...

Подробнее
Номер записи: 15
09-07-2015 дата публикации

MAGNETIC NANO-VECTOR FOR TRANSFERRING NUCLEIC ACIDS SPECIFIC TO LIVER CELL AND MAGNETIC RESONANCE IMAGING

Номер: KR1020150080232A
Автор: YANG, JAE MOON, SUH, JIN SUCK, HUH, YONG MIN, HAAM, SEUNG JOO, PARK, SAHNG WOOK, HEO, DAN
Принадлежит:

The present invention relates to a magnetic nano-vector for transferring nucleic acids specific to liver cells and magnetic resonance imaging and, more specifically, to a magnetic nano-vector which performs simultaneously the function of a vector having a complex structure of the compound for transferring ASGPr-binding ligand-cell, which includes magnetic nano carrier having magnetic nanoparticles binding to asialoglycoprotein receptor (ASGPr)-binding ligands and a nucleic acid structure to be absorbed selectively by liver cells to perform the transfection and transformation by the nucleic acid; and the evaluation of the specificity to liver cells by using a magnetic resonance imaging device. COPYRIGHT KIPO 2015 ...

Подробнее
Номер записи: 16
07-03-2019 дата публикации

SELF-ASSEMBLING PARTICLES AND METHOD FOR PREPARING SAME

Номер: WO2019045529A1
Автор: HAAM, Seungjoo, KIM, Hyun-Ouk, PARK, Geun Seon, LIM, Jong Woo, CHUN, Hae Jin, SONG, Daesub, NA, Woon Sung, YEOM, Min Joo
Принадлежит:

The present invention relates to immuno-directed particles in which an antigenic protein-amphipathic macromolecule polymer is self-assembled, wherein when using the immuno-directed particles of the present invention, it is possible to induce more immune responses even with a smaller amount of vaccine as compared with a conventional vaccine which simply contains an antigenic protein in a carrier, and to provide an efficient vaccine platform in which side effects such as infections of viral diseases can be eliminated.

Подробнее
Номер записи: 17
06-10-2015 дата публикации

ORGANIC NANOQUENCHER BASED ON CONJUGATED POLYMER AND PRODUCING METHOD THEREOF

Номер: KR1020150111400A
Автор: HAAM, SEUNG JOO, HUH, YONG MIN, YANG, JAE MOON, CHOI, JI HYE, CHOI, EUN BI, BAE, SEO RYUNG, BANG, DO YEON, KIM, HYUN OUK, LEE, TAEK SU
Принадлежит:

The present invention relates to an organic nanoquencher based on a conjugated polymer responding to an in vivo oxidation-reduction reaction and a producing method thereof. A pH responsive quencher according to the present invention can evaluate a metabolism environment according to a pH value in vivo with a characteristic that an absorption wavelength band sensitively changes depending on a pH condition. Therefore, it is used as a bioprobe which can effectively measure an early diagnosis and prognosis of a malignant tumor by easily and multiply detecting an in vivo oxidation-reduction reaction discovered in many of various metastatic cancers. COPYRIGHT KIPO 2016 ...

Подробнее
Номер записи: 18
26-07-2017 дата публикации

경구용 바이러스 백신 전달체

Номер: KR0101762003B1
Автор: 함승주, 김현욱, 임종우
Принадлежит: 연세대학교 산학협력단

... 본 발명은 경구용 바이러스 백신 전달체 및 이의 제조방법에 관한 것이다. 본 발명에 따르면, 위의 낮은 pH 환경에서도 파괴되지 않고 장까지 효과적으로 경구용 바이러스 백신을 전달할 수 있다.

Подробнее
Номер записи: 19
05-01-2018 дата публикации

바이러스 검출용 키트

Номер: KR0101814495B1
Автор: 함승주, 김현욱, 송대섭, 김지혜, 장은지, 최지혜
Принадлежит: 주식회사 휴벳바이오, 한국생명공학연구원

... 본 발명은 바이러스 검출용 키트, 바이러스검출용 조성물 및 바이러스 검출방법에 관한 것이다. 본 발명에 따르면, 저가의 비용으로 바이러스 바이러스를 단시간 내에 고효율로 검출할 수 있다.

Подробнее
Номер записи: 20
25-01-2017 дата публикации

ORAL VIRAL VACCINE CARRIER

Номер: KR1020170009207A
Автор: HAAM, SEUNG JOO, KIM, HYUN OUK, LIM, JONG WOO
Принадлежит:

The present invention relates to an oral viral vaccine carrier and a production method thereof. According to the present invention, the oral viral vaccine can be effectively delivered to the intestine without being destroyed even under low pH environment in the stomach. COPYRIGHT KIPO 2017 ...

Подробнее
Номер записи: 21
10-10-2018 дата публикации

SURFACE ENHANCED RAMAN SUBSTRATE AND METHOD FOR MANUFACTURING SAME

Номер: KR101904844B1
Автор: HAAM, SEUNG JOO, LEE, TAEK SU, WI, JUNG SUB, LEE, TAE GEOL
Принадлежит: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY, KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE

The present invention relates to a surface enhanced raman substrate indicating a uniform signal, and a method for manufacturing the same. According to the present invention, the surface enhanced raman substrate has a structure where a metal nano-rod is packed inside a metal nano-bowl, and the present invention effectively absorbs excitation light to have excellent signal amplification capability and indicate the uniform signal since an interval between the metal nano-rods inside the metal nano-bowl and the interval between the metal nano-rod and the metal nano-bowl are narrow. COPYRIGHT KIPO 2018 ...

Подробнее
Номер записи: 22
29-04-2016 дата публикации

Nanoparticle comprising hydrophobic drug conjugated to cationic polymer and hydrophilic drug conjugated to anionic polymer

Номер: KR0101616623B1
Автор: 함승주, 허용민, 노일구, 최지혜, 김현욱, 윤다연
Принадлежит: 연세대학교 산학협력단

... 본 발명은 양이온성 고분자가 결합된 소수성 약물 및 음이온성 고분자가 결합된 친수성 약물을 포함하는 나노입자, 이의 제조방법 및 이의 약제학적 용도에 관한 것이다. 본 발명에 따른 나노입자는 친수성 약물과 소수성 약물을 동시에 전달할 수 있고, 약물의 초기 방출을 제어할 수 있다. 또한, 본 발명에 따른 나노입자는 암세포의 환경에 특이적이기 때문에, 암세포 선택적 진단 또는 치료가 가능하다.

Подробнее
Номер записи: 23
04-09-2017 дата публикации

세이프티 파워 윈도우 시스템 및 그 동작 방법

Номер: KR0101774666B1
Автор: 김영석, 임정민, 정소담, 전경원, 함승주
Принадлежит: 현대자동차주식회사

... 본 발명은 세이프티 파워 윈도우 시스템 및 그 동작 방법에 관한 것으로, 90도 간격으로 위치한 2개의 홀 센서에 의해 생성된 펄스신호에 기초하여 가상의 펄스신호를 생성함으로써, 윈도우 모터가 0.75회전만 회전해도 윈도우에 작용하는 힘을 산출할 수 있어 윈도우와 도어 프레임 사이에 물체의 끼임을 검출할 수 있는 세이프티 파워 윈도우 시스템 및 그 동작 방법을 제공하고자 한다. 이를 위하여, 본 발명은 세이프티 파워 윈도우 시스템에 있어서, 윈도우 모터의 회전 시작점에 위치하여 윈도우 모터의 회전에 따른 제 1 펄스신호를 생성하는 제 1 홀 센서; 상기 제 1 홀 센서와 90도 간격을 두고 위치하여 윈도우 모터의 회전에 따른 제 2 펄스신호를 생성하는 제 2 홀 센서; 및 윈도우 상승시 제 1 펄스신호와 제 2 펄스신호에 기초하여 제 1 가상 펄스신호와 제 2 가상 펄스신호를 생성하고, 상기 제 1 펄스신호와 제 2 펄스신호 및 상기 제 1 가상 펄스신호와 제 2 가상 펄스신호를 기반으로 윈도우에 작용하는 힘을 산출하며, 상기 산출된 힘이 임계치를 초과하는 경우에 윈도우와 도어 프레임 사이에 물체가 끼인 것으로 판단하여 윈도우를 하강시키는 제어부를 포함한다.

Подробнее
Номер записи: 24
02-07-2018 дата публикации

양친매성 폴리 아미노산 고분자 기반 백신 면역보조제 조성물

Номер: KR0101873506B1
Автор: 함승주, 임종우, 김현욱, 최지혜, 윤다연, 김지혜, 송대섭, 염민주, 나운성
Принадлежит: 주식회사 휴벳바이오

... 본 발명은 양친매성 폴리 아미노산 고분자를 함유하는 수중유 에멀젼 상태의 양친매성 고분자 입자를 포함하는 면역보조제 조성물 및 이의 제조방법에 관한 것이다. 본 발명의 면역보조제 조성물은 양친매성 폴리 아미노산 고분자를 이용함으로써 더욱 생체 적합하고, 높은 항체 역가를 갖는 백신 면역보조제 조성물을 제공할 수 있다.

Подробнее
Номер записи: 25
28-08-2015 дата публикации

METHOD FOR MANUFACTURING MAGNETIC COMPOSITE FOR TREATING AND DIAGNOSING CANCER

Номер: KR1020150098515A
Автор: YANG, JAE MOON, SUH, JIN SUCK, HAAM, SEUNG JOO, LEE, EU GENE, HONG, YOO CHAN, KU, MIN HEE, HEO, DAN, HWANG, SEUNG YEONG, HUH, YONG MIN
Принадлежит:

According to an embodiment of the present invention, a method of manufacturing a magnetic composite for treating and diagnosing cancer comprises a step of pyrolyzing precursors of magnetic nanoparticles under the presence of a conjugate polymer. The method for manufacturing a magnetic composite can produce the magnetic composite comprising magnetic nanoparticles coated with a conjugate polymer through a single process, thereby economically and efficiently producing the magnetic composite. COPYRIGHT KIPO 2015 ...

Подробнее
Номер записи: 26
14-07-2016 дата публикации

KIT FOR DETECTING VIRUS

Номер: WO2016111568A1
Автор: HAAM, Seungjoo, KIM, Hyun-Ouk, SONG, Daesub, KIM, Jihye, JANG, Eunji, CHOI, Jihye
Принадлежит:

The present invention relates to a kit for detecting a virus, a composition for detecting a virus, and a method for detecting a virus. According to the present invention, a virus may be detected at a low cost, in a short time, and with high efficiency.

Подробнее
Номер записи: 27
22-06-2017 дата публикации

VACCINE ADJUVANT COMPOSITION BASED ON AMPHIPHILIC POLYAMINO ACID POLYMER, CONTAINING SQUALENE

Номер: WO2017105103A1
Автор: HAAM, Seungjoo, LIM, Jong Woo, KIM, Hyun-Ouk, CHOI, Jihye, YUN, Da Yeon, KIM, Jihye, SONG, Daesub, YEOM, Min Joo, NA, Woon Sung
Принадлежит:

The present invention relates to: an adjuvant composition containing oil-in-water emulsion type amphiphilic polymer particles comprising an amphiphilic polyamino acid polymer; and a preparation method therefor. The adjuvant composition of the present invention uses an amphiphilic polyamino acid polymer, thereby enabling a vaccine adjuvant composition, which is more biocompatible and has a high antibody titer, to be provided.

Подробнее
Номер записи: 28
15-10-2015 дата публикации

Method of preparing for water soluble conductive polymer nanoparticle

Номер: KR0101559202B1
Автор: 양재문, 서진석, 허용민, 함승주, 최지혜, 홍유찬, 이유진
Принадлежит: 연세대학교 산학협력단

... 본 발명은 물 및 양친매성 고분자의 혼합물과 수성 용매 및 공액 고분자의 혼합물을 접촉시키는 것을 포함하는 수용성 공액 고분자 나노입자의 제조방법에 관한 것이다. 본 발명에 따르면 간단한 공정으로 입자 사이즈가 작고 균일하며, 콜로이드 안정성이 좋은 수용성 공액 고분자 나노입자를 제공할 수 있다.

Подробнее
Номер записи: 29
04-02-2016 дата публикации

NANOPARTICLE COMPRISING HYDROPHOBIC DRUG BONDED TO CATIONIC POLYMER AND HYDROPHILIC DRUG BONDED TO ANIONIC POLYMER

Номер: KR1020160013342A
Автор: HAAM, SEUNG JOO, HUH, YONG MIN, NOH, IL KOO, CHOI, JI HYE, KIM, HYUN OUK, YUN, DA YEON
Принадлежит:

The present invention relates to a nanoparticle comprising a hydrophobic drug bonded to a cationic polymer and a hydrophilic drug bonded to an anionic polymer, to a manufacturing method thereof, and to pharmaceutical uses thereof. According to the present invention, the nanoparticle is capable of delivering a hydrophilic drug and a hydrophobic drug at the same time, and controlling initial release of the drug. In addition, according to the present invention, the nanoparticle is specific to environments of cancer cells, and is capable of selectively diagnosing or treating the cancer cells. COPYRIGHT KIPO 2016 ...

Подробнее
Номер записи: 30
18-01-2018 дата публикации

금속산화물 나노입자, 이의 제조방법 및 그 용도

Номер: KR0101819817B1
Автор: 함승주, 김명훈, 김가윤, 신무광
Принадлежит: 연세대학교 산학협력단

... 본 발명은 금속산화물 나노입자, 이의 제조방법 및 이를 이용한 용도에 관한 것으로, 본 발명에 따른 금속산화물 나노입자는 템플레이트(template)을 사용하지 않는 단순한 용액 공정으로 내부에 중공 구조 및 표면에 미세 기공을 형성하여 높은 비표면적을 가질 수 있고, 이를 약물 담지 및 전달 재료, 슈퍼 커패시터 전극 재료 및 촉매 등의 다양한 용도에 적용하여, 우수한 효과를 구현할 수 있다.

Подробнее
Номер записи: 31
23-10-2018 дата публикации

NANOPARTICLE CAPABLE OF DETECTING RESISTANCE TO NEURAMINIDASE INHIBITOR OF INFLUENZA VIRUS

Номер: KR1020180115514A
Автор: HAAM, SEUNG JOO, LEE, JAE MYUN, KIM, HYUN OUK, KIM, JI HYE, SONG, DAE SUB, NA, WOON SUNG, YEOM, MIN JOO
Принадлежит:

The present invention relates to a nanoparticle capable of detecting resistance to neuraminidase inhibitor of influenza virus, a composition including the nanoparticle, a kit, and a method for detecting resistance to neuraminidase inhibitor of influenza virus using the same. By using the nanoparticle of the present invention, it can be confirmed by a simple and rapid method whether influenza virus is a virus resistant to neuraminidase inhibitor and the detection sensitivity is excellent. Moreover, when the kit is used, it is possible to simultaneously confirm whether the virus is highly pathogenic and whether the virus is low pathogenic so that the nanoparticle can be utilized in diagnosis for prescription of a viral therapeutic agent and the like. COPYRIGHT KIPO 2018 (A1,A2,A3) Reaction X (B1,B2,B3) Reaction O ...

Подробнее
Номер записи: 32
18-05-2017 дата публикации

다중 생체물질의 분리방법

Номер: KR0101737695B1
Автор: 함승주, 허용민, 강병훈, 장은지, 한승민, 김현욱
Принадлежит: 연세대학교 산학협력단

... 본 발명은 자성 나노입자의 특성을 이용한 생체 물질을 분리하는 방법에 관한 것이다. 본 발명의 방법은 자성 나노입자의 조성에 따른 자기 민감도(susceptibility) 또는 자화도(magnetization) 차이를 이용하여 분리하려는 생체 물질에 자성 입자를 붙인 후 같은 세기의 외부 자기장에서 궤적의 차이로 여러 생체물질을 한번에 분리 가능한 효과를 나타낸다.

Подробнее
Номер записи: 33
27-10-2011 дата публикации

SEPARATION METHOD OF CARBON NANOTUBES

Номер: WO2011132850A2
Автор: YOO, Kyung Hwa, KIM, Hyung Joon, HWANG, Sung Sic, HAAM, Seung Joo, LIM, Eun Kyung
Принадлежит:

The present invention relates to a method for separating a semiconducting carbon nanotube and a metallic carbon nanotube by using a magnetic nanoparticles surface-modified with an amine group and the like selectively binded to a carboxyl group of a semiconducting carbon nanotube. It is possible to separate carbon nanotubes without additional expensive equipment at low cost.

Подробнее
Номер записи: 34
25-10-2017 дата публикации

STENT FOR RELEASING NANOPARTICLES INCLUDING HYDROPHILIC DRUG COUPLED WITH BIODEGRADABLE POLYMER AND HYDROPHOBIC DRUG

Номер: KR1020170118340A
Автор: HAAM, SEUNG JOO, YUN, DA YEON, LEE, DONG KI, KIM, HYUN OUK
Принадлежит:

The present invention relates to a stent for releasing nanoparticles including a hydrophilic drug coupled with a biodegradable polymer and a hydrophobic drug. The stent comprises: a stent body; a nanofiber layer formed on the stent body; and nanoparticles held in the nanofiber layer. The nanoparticles comprise a micelle structure and a hydrophobic drug held in the micelle structure. The micelle structure is formed by a binder of a hydrophilic polymer, a hydrophobic polymer and a hydrophilic drug. COPYRIGHT KIPO 2017 ...

Подробнее
Номер записи: 35
21-06-2017 дата публикации

POROUS MAGNETIC COMPOSITE, METHOD FOR MANUFACTURING THEREOF, AND IMMOBILIZED ENZYME USING SAME

Номер: KR101749432B1
Автор: HAAM, SEUNG JOO, AHN, JUNG OH, SHIN, MOO KWANG, YOON, NAM KYUNG, LEE, HONG WEON, KANG, BYUNG HOON, HAN, SEUNG MIN, KIM, MYEONG HOON
Принадлежит: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY, KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

The present invention relates to a porous magnetic composite, a method for manufacturing thereof, and a method for producing an immobilized enzyme and separating protein using the same. According to the present invention, the surface of a magnetic body can be easily modified with a transition metal, and at the same time, the porosity and the increased surface area can be obtained. In a process of enzyme immobilization using such the porous magnetic composite, a quantitative value can be used to suggest an accurate enzyme immobilization ratio and activity. As a result, a simplified magnetic body manufacturing process and a surface enhancement effect are concurrently performed, thereby enhancing the immobilization and separation functions of histidine-tagged enzymes and proteins. COPYRIGHT KIPO 2017 ...

Подробнее
Номер записи: 36
03-01-2018 дата публикации

유전자 전달체 및 그 제조방법

Номер: KR0101814879B1
Автор: 함승주, 허용민, 장은지, 한승민, 이훈재
Принадлежит: 연세대학교 산학협력단, 대한민국 (식품의약품안전처장)

... 본 발명은 체내 안정성이 현저히 우수하고, 표적부위 유전자 전달 효율이 우수한 유전자 전달체 및 이를 제조하는 방법에 관한 것이다. 본 발명의 유전자 전달체에 의하면 인지질 이중막을 통하여 세포 독성을 저하시키고, 세포 유입을 개선하였으며, in vivo 환경에서 효소 등에 의한 목적 유전자의 소실을 방지함으로써 유전자 전달 효율을 높이며, 리소좀 pH 조건에서 양이온성 고분자의 이온 완충 능력이 우수하여, 전달 유전자를 세포질 내로 방출시키는 효과가 우수하므로, 유전자 전달체 및 본 발명의 전달체를 이용한 유전자 치료에 효과적으로 사용할 수 있다.

Подробнее
Номер записи: 37
28-11-2019 дата публикации

COMPOSITION FOR DIAGNOSING DISEASES

Номер: WO2019225923A1
Автор: LEE, Hyung Keun, LEE, Dong Ki, HAAM, Seung Joo, YOOK, Jong In, JANG, Sung Ill, KIM, So Young, YEO, A Reum
Принадлежит:

The present invention relates to a composition for diagnosing pancreatic diseases and, more specifically, to a composition enabling the diagnosis of pancreatic cancer, a diagnostic kit comprising same, and a method for providing information for diagnosis by using the composition. The present invention enables accurate prediction or identification of the incidence of pancreatic cancer and, furthermore, enables the diagnosis of pancreatic cancer by effectively distinguishing pancreatic cancer from other types of cancer. In addition, the present invention enables simple and quick diagnosis of pancreatic cancer through a non-invasive method by using monocytes obtained from the blood, serum or plasma obtained from an individual.

Подробнее
Номер записи: 38
20-04-2018 дата публикации

VACCINE IMMUNOADJUVANT COMPOSITION BASED ON AMPHIPHILIC POLYAMINO ACID POLYMER

Номер: KR1020180040547A
Автор: HAAM SEUNG JOO, LIM JONG WOO, KIM HYUN OUK, CHOI JI HYE, YUN DA YEON, KIM JI HYE, SONG DAE SUB, YEOM MIN JOO, NA WOON SUNG
Принадлежит:

The present invention relates to an immunoadjuvant composition containing an amphiphilic polymer particle which is in oil-in-water emulsion state contains an amphiphilic polyamino acid polymer, and a production method thereof. As the immunoadjuvant composition of the present invention uses the amphiphilic polyamino acid polymer, it is possible to provide vaccine immunoadjuvant compositions which are biocompatible and has higher antibody titer. COPYRIGHT KIPO 2018 ...

Подробнее
Номер записи: 39
06-02-2014 дата публикации

APTAMER SPECIFIC TO INTEGRIN ΑVΒ3 AND USE THEREOF

Номер: WO2014021630A1
Автор: LEE, Jung Hwan, HAAM, Seungjoo, HUH, Yong-Min, CHAE, Young Chan, RYU, Sung Ho, LIM, Eun-Kyung, KIM, Jong In
Принадлежит:

The present invention relates to a DNA aptamer specifically binding to integrin αvβ3, and a composition for diagnosing cancer or metastasis of cancer including the aptamer as an active ingredient. Also, the present invention relates to a composition for imaging neoplastic diseases including the aptamer, and a contrast medium including same.

Подробнее
Номер записи: 40
27-08-2018 дата публикации

바이러스 감염의 치료용 폴리아미노산 기반의 생체환경 감응형 나노입자

Номер: KR0101891715B1
Автор: 함승주, 김지혜, 김현욱, 최지혜, 임종우, 송대섭, 나운성, 염민주
Принадлежит: 연세대학교 산학협력단, 고려대학교 산학협력단

... 본 발명은 바이러스 감염의 치료용 폴리아미노산 기반의 생체환경 감응형 나노입자에 관한 것으로, 보다 상세하게는, 생체환경에 특이적으로 감응하는 폴리 아미노산 기반의 나노입자를 사용하여 바이러스 감염된 세포를 인식하고 활성산소를 조절하여 세포의 항상성을 유지함으로써 바이러스 감염을 치료하는 효과를 제공한다.

Подробнее
Номер записи: 41
13-06-2017 дата публикации

SAFETY POWER WINDOW SYSTEM AND OPERATING METHOD THEREOF

Номер: KR1020170065368A
Автор: KIM, YOUNG SUK, LIM, JUNG MIN, JEONG, SO DAM, JEON, KYEONG WON, HAM, SEUNG JU
Принадлежит:

The present invention relates to a safety power window system and an operating method thereof which generate a virtual pulse signal based on a pulse signal generated by two Hall sensors positioned at intervals of 90 degrees to calculate a force applied to a window when a window motor rotates only 0.75 revolutions to detect an object being caught between the window and a door frame. According to the present invention, the safety power window system comprises: a first Hall sensor positioned on a rotation start point of a window motor to generate a first pulse signal by rotation of the window motor; a second Hall sensor positioned at intervals of 90 degrees with the first Hall sensor to generate a second pulse signal by rotation of the window motor; and a control unit to generate a first and a second virtual pulse signal based on the first and the second pulse signal when a window rises, calculate a force applied to the window based on the first and the second pulse signal and the first and ...

Подробнее
Номер записи: 42
18-07-2016 дата публикации

KIT FOR DETECTING VIRUS

Номер: KR1020160085718A
Автор: HAAM, SEUNG JOO, KIM, HYUN OUK, KIM, JI HYE, SONG, DAE SUB
Принадлежит:

The present invention relates to a kit for detecting viruses, a composition for detecting viruses, and a method for detecting viruses. According to the present invention, viruses can be detected at low costs, in a short time, and with high efficiency, and a kit having a more improved sensitivity and accuracy can be produced. COPYRIGHT KIPO 2016 (AA) Hydrophilic-hydrophobic polymer (BB) Fluorescent dye (CC) Dulling agent ...

Подробнее
Номер записи: 43
24-02-2016 дата публикации

Organic Nanoquencher Based On Conjugated Polymer And Preparation Method Thereof

Номер: KR0101597023B1
Автор: 함승주, 허용민, 양재문, 최지혜, 최은비, 배서령, 방도연, 김현욱, 이택수
Принадлежит: 연세대학교 산학협력단

... 본 발명은 생체 내 산화-환원 반응에 감응하는 공액고분자 기반 유기나노켄처 및 이의 제조방법에 관한 것이다. 본 발명에 따른 pH 감응형 켄처는 pH 상태에 따라 민감하게 흡수파장대가 변화하는 것을 특징으로 생체 내 pH 값에 따른 대사환경을 평가할 수 있다. 이에 따라, 다양한 전이암에 다수 발견되는 생체 내 산화-환원 반응에 대한 다중 검출이 용이해 짐으로써, 악성 종양의 조기 진단 및 예후를 효과적으로 판단할 수 있는 바이오프로브로 이용될 수 있다.

Подробнее
Номер записи: 44
15-03-2017 дата публикации

POLYAMINO ACID-BASED BIOENVIRONMENT-SENSITIVE NANOPARTICLE FOR EARLY CANCER DIAGNOSIS OR CANCER THERAPIES

Номер: KR101717010B1
Автор: HAAM, SEUNG JOO, KIM, JI HYE, KIM, HYUN OUK, CHOI, JI HYE, SONG, DAE SUB, NA, WOON SUNG, YEOM, MIN JOO
Принадлежит: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY, KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION

The present invention relates to a polyamino acid-based bioenvironment-sensitive nanoparticle for early cancer diagnoses or cancer therapies. More specifically, the use of polyamino acid-based nanoparticle specifically sensitized by bioenvironment enables recognition of cancer cells and cancer diagnoses. Owing to drug supportability of the nanoparticle, the polyamino acid-based bioenvironment-sensitive nanoparticle provides therapeutic effects for cancer. COPYRIGHT KIPO 2017 ...

Подробнее
Номер записи: 45
04-07-2016 дата публикации

OPTICAL PROBE

Номер: KR0101635376B1
Автор: 양재문, 홍유찬, 이유진, 서진석, 함승주, 최지혜
Принадлежит: 연세대학교 산학협력단

... 본 발명의 일 실시예에 따른 광학 프로브는 다당류 및 공액 고분자를 포함한다. 상기 광학 프로브는 세포 독성이 강한 계면활성제를 사용하지 않고, 비색 결정법의 금속을 사용하지 않아 인체에 무해하다. 이러한 광학 프로브는 악성 종양에 표적화가 가능하고, 악성 종양의 진행 정도에 따라 다른 색을 나타내므로 높은 효율로 악성 종양의 정성 및 정량 분석이 가능하다. 또한, 상기 광학 프로브는 정상 세포에 손상을 주지 않고, 악성 종양 세포만을 광열 치료할 수 있다.

Подробнее
Номер записи: 46
06-01-2016 дата публикации

METHOD FOR MANUFACTURING MAGNETIC HYBRID FOR TREATMENT AND DIAGNOSIS OF CANCER

Номер: KR0101582965B1
Автор: 양재문, 서진석, 함승주, 이유진, 홍유찬, 구민희, 허단, 황승연, 허용민
Принадлежит: 연세대학교 산학협력단

... 본 발명의 일 실시예에 따른 암 치료 및 진단용 자성복합체의 제조 방법은 공액 고분자 존재하에 자성 나노입자의 전구체를 열분해하는 단계를 포함한다. 상기 자성복합체의 제조 방법은 한 번의 공정으로 공액 고분자로 코팅된 자성 나노입자를 포함하는 자성복합체를 제조할 수 있어 자성복합체를 경제적이고 효율적으로 생산할 수 있다.

Подробнее
Номер записи: 47
28-12-2016 дата публикации

COMPOSITE OF INORGANIC NANOPARTICLE AND CONDUCTIVE POLYMER USING AROMATIC COMPOUNDS

Номер: KR1020160149477A
Автор: HAAM, SEUNG JOO, HUH, YONG MIN, SUH, JIN SUCK, LEE, TAEK SU, BANG, DO YEON, KIM, JIN YOUNG, KANG, BYUNG HOON
Принадлежит:

The present invention relates to a composite of an inorganic nanoparticle and a conductive polymer using aromatic compounds, and to a production method thereof. More specifically, the present invention relates to a composite which can be applied to a diagnosis and treatment for cancer. Without the involvement of strong acid and a high temperature, it is possible to synthesize an inorganic nanoparticle and a conductive polymer, by reducing affinity among conductive polymers using aromatic compounds. The present invention further relates to a production method thereof. COPYRIGHT KIPO 2017 ...

Подробнее
Номер записи: 48
07-06-2018 дата публикации

PORTABLE FLUORESCENCE READER

Номер: WO2018101756A1
Автор: HAAM, Seung Joo, SONG, Dae Sub, JEONG, Hyoung Hwa
Принадлежит:

The present invention relates to a portable fluorescence reader, and according to one aspect of the present invention, provided is a fluorescence reader comprising: a body having a loading groove in which a sample containing a fluorescence reagent is to be inserted; a sensing unit for sensing the loading of the sample in the loading groove; an optical unit which is prepared inside of the main body, emits light to the sample, and detects the light having passed through the sample; and a control unit for operating the optical unit on the basis of the sensing result of the sensing unit and outputting the detection result to the outside.

Подробнее
Номер записи: 49
07-12-2015 дата публикации

POROUS NANOPARTICLE AND METHOD FOR PRODUCING POROUS NANOPARTICLE

Номер: KR1020150136296A
Автор: YANG, JAE MOON, SUH, JIN SUCK, HONG, YOO CHAN, HWANG, SEUNG YEONG, HAAM, SEUNG JOO, CHOI, JI HYE
Принадлежит:

The present invention relates to a porous nanoparticle, and a method for producing the porous nanoparticle. According to an embodiment of the present invention, the production method of the present invention can provide the porous nanoparticle which is composed of a pure conjugated polymer and maintains original characteristics of the conjugated polymer intact. COPYRIGHT KIPO 2016 ...

Подробнее
Номер записи: 50
06-01-2016 дата публикации

BIOENVIRONMENT-SENSITIVE NANOPARTICLE COMPRISING POLYMER WITH COMPLEMENTARY CHARGE

Номер: KR1020160000935A
Автор: HAAM, SEUNG JOO, HUH, YONG MIN, KIM, HYUN OUK, CHOI, JI HYE, JANG, EUN JI, KANG, BYUNG HOON, NOH, IL KOO, SONG, SEUNG WON, HAN, SEUNG MIN
Принадлежит:

The present invention relates to a bioenvironment-sensitive nanoparticle comprising a polymer with a complementary charge. The present invention further relates to a production method thereof and a pharmaceutical use thereof. According to the present invention, the nanoparticle stays in a stable state in an environment outside a cell. Thus, efficient and stable delivery of a target molecule such as a drug is possible even with a small quantity. Furthermore, the nanoparticle of the present invention tends to be specific in the cancer cell environment. Thus, the cancer cell-specific diagnosis or treatment is possible as well. COPYRIGHT KIPO 2016 (AA) (BB) (C1,C2) Hydrophilic polymer or polyamino acid (DD) Hydrophobic polymer or polyamino acid (EE) Hydrophilic polymer having a positive charger or polyamino acid (FF) Hydrophilic molecule having a negative charger (GG) Forming a ...

Подробнее
Номер записи: 51
12-02-2016 дата публикации

Polyaniline coordinated with transition metal and preparation method thereof

Номер: KR0101593295B1
Автор: 함승주, 허용민, 양재문, 최지혜, 최은비, 배서령, 강병훈, 김명훈, 홍유찬, 김현욱
Принадлежит: 연세대학교 산학협력단

... 본 발명은 전이금속이 배위 결합된 폴리아닐린, 이를 코어로서 포함하는 코어쉘 구조의 나노입자 및 이들의 제조방법에 관한 것이다. 본 발명에 따른 전이금속이 배위 결합된 폴리아닐린 및 나노입자는 전이금속을 포함하는 코어쉘 구조의 산화제를 사용하여 제조할 수 있으며, 이렇게 제조된 폴리아닐린은 도핑된 상태로 제조되므로 제조공정이 간단할 뿐만 아니라, 용매에 대한 분산성이 향상되며, 폴리아닐린의 밴드갭 레벨 조절이 용이하다는 이점이 있다.

Подробнее
Номер записи: 52
15-09-2015 дата публикации

POLYANILINE COORDINATE-BONDED WITH TRANSITION METAL AND MANUFACTURING METHOD THEREOF

Номер: KR1020150104258A
Автор: HAAM, SEUNG JOO, HUH, YONG MIN, YANG, JAE MOON, CHOI, JI HYE, CHOI, EUN BI, BAE, SEO RYUNG, KANG, BYUNG HOON, KIM, MYEONG HOON, HONG, YOO CHAN, KIM, HYUN OUK
Принадлежит:

The present invention relates to polyaniline coordinate-bonded with a transition metal, a nanoparticle of a core shell structure comprising the same as a core, and a manufacturing method thereof. According to the present invention, polyaniline coordinate-bonded with a transition metal and a nanoparticle can be manufactured by using an oxidizing agent of a core shell structure comprising the transition metal. The polyaniline manufactured in a doped state has an advantage of easily controlling the level of a band gap of polyaniline, with a simple manufacturing process and improved dispersibility with respect to a solvent. COPYRIGHT KIPO 2015 ...

Подробнее
Номер записи: 53
31-05-2018 дата публикации

COMPOSITION FOR DIAGNOSIS OF DISEASES

Номер: WO2018097646A1
Автор: LEE, Hyung Keun, LEE, Dong Ki, HAAM, Seung Joo, YOOK, Jong In
Принадлежит:

The present invention relates to a composition for diagnosis of pancreatic diseases, and, more specifically, to a composition which can diagnose pancreatic cancer, a diagnostic kit comprising the same, and a method of providing information for diagnosis using the composition. The present invention can accurately predict or identify the risk of pancreatic cancer, and moreover, can diagnose pancreatic cancer by effectively distinguishing pancreatic cancer from different types of cancer. In addition, in the present invention, it is possible to diagnose pancreatic cancer simply and rapidly through a non-invasive method by using monocytes obtained from blood, serum or plasma obtained from an individual.

Подробнее
Номер записи: 54
12-06-2018 дата публикации

PORTABLE FLUORESCENCE READER

Номер: KR1020180063622A
Автор: HAAM, SEUNG JOO, SONG, DAE SUB, JEONG, HYOUNG HWA
Принадлежит:

The present invention relates to a portable fluorescence reader. According to one aspect of the present invention, the reader comprises: a main body having a mounting groove for inserting a sample containing a fluorescent reagent; a detecting unit for detecting whether or not the sample is mounted on the mounting groove; an optical unit disposed in the main body, irradiating light toward the sample, and detecting light passing through the sample; and a controller operating the optical unit based on the detected result of the detecting unit and outputting the detected result to the outside. COPYRIGHT KIPO 2018 ...

Подробнее
Номер записи: 55
27-08-2015 дата публикации

PREPARATION METHOD FOR MAGNETIC COMPOSITE FOR TREATING AND DIAGNOSING CANCER

Номер: WO2015126146A1
Автор: YANG, Jae Moon, SUH, Jin Suck, HAAM, Seung Joo, LEE, Eu Gene, HONG, Yoo Chan, KU, Min Hee, HEO, Dan, HWANG, Seung Yeon, HUH, Yong Min
Принадлежит:

A preparation method for a magnetic composite for treating and diagnosing cancer, according to one embodiment of the present invention, comprises a step of pyrolyzing a precursor of a magnetic nanoparticle in the presence of a conjugated polymer. The preparation method for a magnetic composite can produce a magnetic composite economically and efficiently because a magnetic composite comprising a magnetic nanoparticle coated with a conjugated polymer can be prepared by a single process.

Подробнее
Номер записи: 56
31-05-2017 дата публикации

나노입자를 포함하는 온열치료용 조성물

Номер: KR0101742884B1
Автор: 허용민, 함승주, 이상화, 박상은, 이재원, 이택수, 배샛별, 최돈웅, 강병훈
Принадлежит: 연세대학교 산학협력단, 가천대학교 산학협력단, 대한민국 (식품의약품안전처장)

... 본 발명은 본 발명은 온열치료에 우수한 효과를 가지는 나노입자, 상기 나노입자의 제조방법, 그리고 상기 나노입자를 포함하는 온열치료용 조성물 및 상기 조성물을 포함하는 온열치료 방법에 관한 것으로, 본 발명에 따르면, 종양 주변세포에 독성 없이, 본 발명의 나노입자에 의한 온열치료에 의하여 종양세포를 사멸시킬 수 있고, 특히 세포독성이 없어 부작용 없이 온열치료 분야에서 사용될 수 있다. 또한, 본 발명의 나노입자는 실리카 코어 및 금 표면층을 포함하고 있어, 근적외선 영역에서 높은 흡광력을 통해서 온열치료 시 나노입자에 의한 온도의 변화가 커서, 항암 치료의 효과를 높일 수 있다.

Подробнее
Номер записи: 57
23-07-2015 дата публикации

BIOMARKER SPECIFIC AMPHIPHILIC NANOPARTICLE

Номер: KR101538268B1
Автор: HAAM, SEUNG JOO, HUH, YONG MIN, SUH, JIN SUCK, YANG, JAE MOON, KIM, HYUN OUK, CHOI, JI HYE, JANG, EUN JI, KANG, BYUNG HOON, NOH, IL KOO, BAE, SEO RYUNG
Принадлежит: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY

The present invention relates to a biomarker specific amphiphilic nanoparticle, and more specifically, to an amphiphilic nanoparticle capable of being used as a diagnosis or treatment type drug or a gene delivery as an inflow in a cell and a selective decomposition are effectively done after selectively recognizing and combining a proteolytic enzyme which is specifically realized on a cell membrane of a certain cell. The amphiphilic nanoparticle is able to be used for a diagnosis or a treatment of a disease. The present invention includes: a hydrophilic polymer and hydrophobic polymer-containing block copolymer (A); and a peptide and hydrophilic polymer-containing block copolymer (B) dissolved by the proteolytic enzyme. COPYRIGHT KIPO 2015 (AA) Driving mechanism of an existing nano-delivery (BB) Driving mechanism of a nano-delivery of the present invention (C1,C2) Hydrophilic polymer or polyamino acid (D1,D2) Hydrophobic polymer or polyamino acid (EE) Spacer (FF) Target aiming particle ...

Подробнее
Номер записи: 58
10-11-2017 дата публикации

생분해성 고분자가 결합된 친수성 약물과 소수성 약물을 포함하는 나노입자를 방출하는 스텐트

Номер: KR0101795923B1
Автор: 함승주, 윤다연, 이동기, 김현욱
Принадлежит: 연세대학교 산학협력단

... 본 발명은 생분해성 고분자가 결합된 친수성 약물과 소수성 약물을 포함하는 나노입자를 방출하는 스텐트에 관한 것으로, 스텐트 본체; 스텐트 본체에 형성되는 나노섬유층; 및 나노섬유층에 담지되는 나노입자를 포함하며, 나노입자는 마이셀 구조체 및 마이셀 구조체 내부에 담지되는 소수성 약물을 포함하고, 마이셀 구조체는 친수성 고분자, 소수성 고분자 및 친수성 약물의 결합체로 형성되는 것을 특징으로 하는 스텐트를 제공한다.

Подробнее
Номер записи: 59
19-04-2016 дата публикации

KIT FOR DETECTING VIRUS

Номер: KR1020160042373A
Автор: HAAM, SEUNG JOO, SONG, DAE SUB, KIM, HYUN OUK
Принадлежит:

The present invention relates to a kit for detecting virus and a method for detecting virus. Specifically, the present invention relates to a kit for detecting influenza virus and a method for detecting influenza virus. According to the present invention, the kit is capable of detecting highly pathogenic influenza virus in a short period of time, with high efficiency, and at low costs. The kit comprises: an amphiphilic particle comprising a copolymer including hydrophilic polymer and a hydrophobic polymer; and enzyme for specifically degrading hemagglutinin of virus. COPYRIGHT KIPO 2016 (AA) Insert high pathogenic and low pathogenic virus (BB) Activate Hemagglutinin by Furin or Trypsin (CC) Insert polymersome (FluSome) or self-quenched dye-carried micelle (D1,D2) HPAI (High pathogenicity) (E1,E2) LPAI (Low pathogenicity) (FF) Measurement result ...

Подробнее
Номер записи: 60
03-12-2015 дата публикации

POROUS NANOPARTICLES AND PRODUCTION METHOD FOR POROUS NANOPARTICLES

Номер: WO2015182824A1
Автор: YANG, Jae Moon, SUH, Jin Suck, HONG, Yoo Chan, HWANG, Seung Yeon, ΗΑΑΜ, Seung Joo, CHOI, Ji Hye
Принадлежит:

The present invention relates to porous nanoparticles and a production method for porous nanoparticles. The production method for porous nanoparticles according to one embodiment can provide porous nanoparticles which are composed of pure conjugated polymers and which maintain the intrinsic characteristics of the conjugated polymers.

Подробнее
Номер записи: 61
20-10-2017 дата публикации

METAL OXIDE NANOPARTICLE, PRODUCTION METHOD THEREOF, AND USE THEREOF

Номер: KR1020170116739A
Автор: HAAM, SEUNG JOO, KIM, MYEONG HOON, KIM, GA YUN, SHIN, MOO KWANG
Принадлежит:

The present invention relates to a metal oxide nanoparticle, a production method thereof, and a use thereof. According to the present invention, the metal oxide nanoparticle has a high specific area by forming microbubbles on a surface and a hollow structure therein via a simple solution process without using templates. By applying the same to various uses such as catalysts, materials for super capacitor electrodes, and materials for supporting and delivering drugs, it is possible to achieve excellent effects. COPYRIGHT KIPO 2017 ...

Подробнее
Номер записи: 62
07-03-2016 дата публикации

METHOD FOR ISOLATING MULTIPLE BIOMATERIALS

Номер: KR1020160024804A
Автор: HAAM, SEUNG JOO, HUH, YONG MIN, KANG, BYUNG HOON, JANG, EUN JI, HAN, SEUNG MIN, KIM, HYUN OUK
Принадлежит:

The present invention relates to a method for isolating biomaterials using characteristics of magnetic nanoparticles which are represented by chemical formula 1. The method of the present invention uses the difference in magnetic susceptibility or magnetization depending on the composition of the magnetic nanoparticles, and thus, magnetic nanoparticles are attached to the biomaterials to be isolated, and then several biomaterials can be isolated from each other at the same time due to different traces in the external magnetic field with the same intensity. COPYRIGHT KIPO 2016 ...

Подробнее
Номер записи: 63
03-04-2017 дата публикации

다공성 나노입자 및 다공성 나노입자의 제조 방법

Номер: KR0101722556B1
Автор: 양재문, 서진석, 홍유찬, 황승연, 함승주, 최지혜
Принадлежит: 연세대학교 산학협력단

... 본 발명은 다공성 나노입자 및 다공성 나노입자의 제조 방법에 관한 것이다. 일 실시예에 따른 다공성 나노입자의 제조 방법은 순수한 공액 고분자로 이루어지며, 공액 고분자의 본연의 특성을 그대로 유지하는 다공성 나노입자를 제공할 수 있다.

Подробнее
Номер записи: 64
25-07-2016 дата публикации

상보적인 전하를 가지는 고분자를 포함하는 생체환경 감응형 나노입자

Номер: KR0101642571B1
Автор: 함승주, 허용민, 김현욱, 최지혜, 장은지, 강병훈, 노일구, 송승원, 한승민, 이훈재, 천해진
Принадлежит: 연세대학교 산학협력단

... 본 발명은 상보적인 전하를 가지는 고분자를 포함하는 생체환경 감응형 나노입자, 이의 제조방법 및 이의 약제학적 용도에 관한 것이다. 본 발명에 따른, 나노입자는 세포 밖 환경에서 안정하기 때문에, 적은 양으로도, 약물 등의 목적 물질을 안정하고 효율적으로 전달할 수 있다. 또한, 본 발명의 나노입자는 암세포의 환경에 특이적이기 때문에, 암세포 선택적 진단 또는 치료가 가능하다.

Подробнее
Номер записи: 65
26-06-2017 дата публикации

VACCINE IMMUNOADJUVANT COMPOSITION BASED ON AMPHIPHILIC POLY-AMINO ACID COMPRISING SQUALENE

Номер: KR1020170072157A
Автор: HAAM, SEUNG JOO, LIM, JONG WOO, KIM, HYUN OUK, CHOI, JI HYE, YUN, DA YEON, KIM, JI HYE, SONG, DAE SUB, YEOM, MIN JOO, NA, WOON SUNG
Принадлежит:

The present invention relates to an immunoadjuvant composition comprising an amphiphilic polymer particle in an oil-in-water emulsion state including an amphiphilic polyamino acid polymer, and to a production method thereof. The immunoadjuvant composition of the present invention can provide a vaccine immunoadjuvant composition which is more biocompatible and has a high antibody titer by using an amphiphilic polyamino acid polymer. COPYRIGHT KIPO 2017 ...

Подробнее
Номер записи: 66
29-01-2015 дата публикации

PRODUCTION METHOD FOR WATER-SOLUBLE CONJUGATED POLYMER NANOPARTICLES

Номер: WO2015012455A1
Автор: YANG, Jae Moon, SUH, Jin Suck, HUH, Yong Min, HAAM, Seung Joo, CHOI, Ji Hye, HONG, Yoo Chan, LEE, Eu Gene
Принадлежит:

The present invention relates to a production method for water-soluble conjugated polymer nanoparticles, the method comprising establishment of contact between: a mixture of water and an amphipathic polymer; and a mixture of an aqueous solvent and a conjugated polymer. The present invention makes it possible to use a straightforward process in order to provide water-soluble conjugated polymer nanoparticles having a small and uniform particle size and good colloidal stability.

Подробнее
Номер записи: 67
19-10-2015 дата публикации

KIT FOR DETECTING VIRUS

Номер: KR101561395B1
Автор: HAAM, SEUNG JOO, SONG, DAE SUB, KIM, HYUN OUK
Принадлежит: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY

The present invention relates to a kit and a method for detecting a virus and, more specifically, to a kit and a method for detecting an influenza virus. According to the present invention, the present invention can detect a highly pathogenic influenza virus with high efficiency at low costs. COPYRIGHT KIPO 2016 (AA) Putting viruses of low pathogenicity and high pathogenicity (BB) HA1 and HA2 activation by protease (Hemagglutinin activation by Furin or Trypsin) (CC) Putting polymersome (FluSome) or micelle dipped with self-quenched dye (DD) HPAI (high pathogenicity) or LPAI (low pathogenicity) (EE) Measurement result (FF) HPAI (high pathogenicity) (GG) LPAI (low pathogenicity) ...

Подробнее
Номер записи: 68
01-06-2018 дата публикации

COMPOSITION FOR DIAGNOSING DISEASE

Номер: KR1020180058650A
Автор: LEE, HYUNG KEUN, LEE, DONG KI, HAAM, SEUNG JOO, YOOK, JONG IN
Принадлежит:

The present invention relates to a composition for diagnosis of pancreatic diseases, and more particularly, to a composition capable of diagnosing pancreatic cancer, a diagnostic kit comprising the same, and a method for providing information for diagnosis using the composition. The present invention can accurately predict or identify onset possibility of pancreatic cancer, and can effectively diagnose different types of cancer. In addition, in the present invention, the pancreatic cancer can be simply and rapidly diagnosed by non-invasive method using monocytes obtained from blood, serum or plasma obtained from an individual. COPYRIGHT KIPO 2018 ...

Подробнее
Номер записи: 69
01-10-2015 дата публикации

MULTI-SENSING PLATFORM USING NANOPOROUS CANTILEVER SENSOR

Номер: KR101556378B1
Автор: NA, SUNG SOO, PARK, JIN SUNG, HAAM, SEUNG JOO, BANG, DO YEON
Принадлежит: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION, INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY

The present invention relates to a multi-sensing platform using a nanoporous cantilever sensor comprising: a substrate which is a plate shape; a tip which is formed on a front end of the substrate; and a nanoporous structure which is formed on the tip. A nanoporous cantilever according to the present invention greatly improves detection sensitivity in terms of a material for detection compared with a conventional cantilever by forming nanoporous structure consisting of nanopores and nano-flow channels or the like on the tip and is possible to distinguish molecules for detection because of getting a surface-enhanced Raman signal. COPYRIGHT KIPO 2015 (CC) Preparation example (BB) Comparative example 2 (AA) Comparative example 1 ...

Подробнее
Номер записи: 70
02-03-2017 дата публикации

방향족 화합물을 활용한 전도성 고분자와 무기 나노입자의 복합체

Номер: KR0101711738B1
Автор: 함승주, 허용민, 서진석, 이택수, 방도연, 김진영, 강병훈
Принадлежит: 연세대학교 산학협력단

... 본 발명은 방향족 화합물을 활용한 전도성 고분자와 무기 나노입자의 복합체 및 이의 제조방법에 관한 것으로, 강한 산성 및 고온의 조건 없이도 방향족 화합물을 활용하여 전도성 고분자 간의 친화력을 줄임으로써 전도성 고분자와 무기 나노입자를 합성하여, 암 진단 및 치료에 효과적으로 활용 가능한 복합체 및 이의 제조방법에 관한 것이다.

Подробнее
Номер записи: 71
18-07-2016 дата публикации

KIT FOR DETECTING VIRUS

Номер: KR1020160085717A
Автор: HAAM, SEUNG JOO, KIM, HYUN OUK, SONG, DAE SUB, KIM, JI HYE, JANG, EUN JI, CHOI, JI HYE
Принадлежит:

The present invention relates to a kit for detecting virus, a composition for detecting virus, and a method for detecting virus. According to the present invention, the virus can be detected at a low cost, with high efficiency, and in a short time. The kit for detecting virus comprises biomolecules and probes. COPYRIGHT KIPO 2016 (AA) Insert high pathogenic virus and low pathogenic virus (BB) Insert a probe according to the present invention (CC) Activate hemagglutinin by furin or trypsin (DD) Measuring a change in a signal (EE) HPAI (high pathogenicity) or LPAI (low pathogenicity) ...

Подробнее
Номер записи: 72
25-07-2017 дата публикации

BIO-ENVIRONMENT SENSITIVE NANOPARTICLE BASED ON POLYAMINO ACID FOR TREATING VIRAL INFECTION

Номер: KR1020170085784A
Автор: HAAM, SEUNG JOO, KIM, JI HYE, KIM, HYUN OUK, CHOI, JI HYE, LIM, JONG WOO, SONG, DAE SUB, NA, WOON SUNG, YEOM, MIN JOO
Принадлежит:

The present invention relates to a bio-environment sensitive nanoparticle based on polyamino acid for treating viral infection. When using the polyamino acid-based nanoparticle which specifically respond to the bio-environment, virus-infected cells are recognized, active oxygen is regulated and cell homeostasis is maintained, thereby providing an effect of treating viral infection. COPYRIGHT KIPO 2017 ...

Подробнее
Номер записи: 73
02-02-2012 дата публикации

STIMULUS SENSITIVE MAGNETIC NANOCOMPOSITE USING PYRENE POLYMER, AND CONTRAST MEDIUM COMPOSITION CONTAINING THE NANOCOMPOSITE

Номер: KR2012015125A1
Автор: HAAM, Seung Joo, SUH, Jin Suck, HUH, Yong Min, YANG, Jae Moon, LIM, Eun Kyung
Принадлежит:

The present invention relates to a stimulus sensitive magnetic nanocomposite using a pyrene polymer, and a preparation method thereof, and more specifically, to a target specific stimulus sensitive magnetic nanocomposite comprising: an amphiphilic compound comprising one or more hydrophobic regions and one or more hydrophilic regions in which magnetic nanoparticles and a material having a pyrene structure are contained; and a pharmaceutically active ingredient, wherein the amphiphilic compound surrounds the pharmaceutically active ingredient, the pharmaceutically active ingredient surrounds the magnetic nanoparticles, and the pharmaceutically active ingredient is chemically bonded in the hydrophobic regions, thereby allowing the magnetic nanoparticles and the pharmaceutically active ingredient to show stable and excellent magnetic properties in an aqueous solution, enabling a rapid release behavior of a drug according to the specific stimulus, and enabling a target specificity by the tissue ...

Подробнее
Номер записи: 74
08-07-2015 дата публикации

POLYMER HYDROGEL COMPLEX AND MANUFACTURING METHOD THEREOF

Номер: KR1020150077495A
Автор: YANG, JAE MOON, HUH, YONG MIN, SUH, JIN SUCK, CHEONG, JAE HO, PARK, EUN SUNG, HAAM, SEUNG JOO, KU, MIN HEE, PARK, JUNG MIN
Принадлежит:

The present invention relates to a polymer hydrogel complex and a manufacturing method thereof and, more specifically, to a polymer hydrogel complex for near-infrared ray area activation type imaging diagnosis, a manufacturing method thereof, and uses thereof, which comprises: anionic polysaccharide which is not reformed and can be targeting a biomarker; and a cationic polymer covalently bonded with a fluorescent material. COPYRIGHT KIPO 2015 (EE) 684nm emission (DD) 675nm adsorption (CC) Cancer stem cell film revealing CD 44 (BB) Optical image diagnosis of near-infrared rays area (AA) CD44 targeting (KK) Negative charge (JJ) Optical image diagnosis nano composite (NIRSH) activated in a near-infrared ray area (II) Positive charge (FF) Polyethyleneimine (PEI) (GG) Hyaluronic acid (HA) (HH) Cy5.5-PEI covalent bonding ...

Подробнее
Номер записи: 75
11-02-2016 дата публикации

Paint for measuring deformation of structure having the magnetic material, tape comprising the same and deformation rate measuring method of structure using the same

Номер: KR0101592950B1
Автор: 함승주, 임윤묵, 임윤철, 박요셉
Принадлежит: 연세대학교 산학협력단, (주)기술과가치

... 본 발명은 구조물의 변형률 측정용 도료, 이를 포함하는 테이프 및 이를 이용한 구조물의 변형률 측정방법에 관한 것으로, 보다 구체적으로 본 발명의 구조물의 변형률 측정용 도료는 일정한 간격으로 배열된 자성체를 포함한다. 다양한 산업 구조물이 사용하중 등에 의해 변형되는 경우, 상기 구조물의 표면에 직접 형성되거나 테이프 등을 이용하여 부착된 본 발명에 따른 도료의 자속 변화를 측정함으로써 구조물의 정확한 변형률을 측정할 수 있으며, 이를 통하여 구조물의 과다변형으로 인한 안전사고의 발생을 미연에 방지할 수 있다.

Подробнее
Номер записи: 76
11-08-2016 дата публикации

구조물 변형 측정용 도료, 이를 포함하는 테이프 및 이를 이용한 구조물의 변형 측정방법

Номер: KR0101647352B1
Автор: 함승주, 임윤묵, 임윤철, 박요셉, 강병훈
Принадлежит: 연세대학교 산학협력단, (주)기술과가치

... 본 발명은 구조물 변형 측정용 도료, 이를 포함하는 테이프 및 이를 이용한 구조물의 변형 측정방법에 관한 것으로, 보다 구체적으로 본 발명의 구조물 변형 측정용 도료는 구조물의 변형에 따라 변형 여부 및 변형 정도를 용이하게 확인할 수 있도록 자성 광결정을 함유함으로써 구조물의 변형을 측정하는데 유용하게 활용될 수 있다. 또한, 본 발명에 의하면, 사용하중 등에 의하여 발생하는 구조물의 변형 및 변형 정도를 용이하게 측정할 수 있으므로 구조물의 과다변형으로 인한 안전사고의 발생을 미연에 방지할 수 있다.

Подробнее
Номер записи: 77
09-08-2018 дата публикации

휴대형 형광 리더기

Номер: KR0101886348B1
Автор: 함승주, 송대섭, 정형화
Принадлежит: 주식회사 휴벳바이오

... 본 발명은 휴대형 형광 리더기에 관한 것으로, 본 발명의 일 측면에 따르면, 본 발명의 일 측면에 따르면, 형광시약이 함유된 샘플이 삽입되기 위한 장착 홈을 갖는 본체와, 장착 홈 내 샘플 장착을 감지하기 위한 감지부와, 본체 내부에 마련되며, 상기 샘플을 향하여 광을 조사하고, 샘플을 통과한 광을 검출하기 위한 광학부 및 감지부의 감지 결과에 기초하여 광학부를 작동시키고, 검출 결과를 외부로 출력하기 위한 제어부를 포함하는 형광 리더기가 제공된다.

Подробнее
Номер записи: 78
27-10-2011 дата публикации

SEPARATION METHOD OF CARBON NANOTUBES

Номер: WO2011132850A3
Автор: YOO, Kyung Hwa, KIM, Hyung Joon, HWANG, Sung Sic, HAAM, Seung Joo, LIM, Eun Kyung
Принадлежит:

The present invention relates to a method for separating a semiconducting carbon nanotube and a metallic carbon nanotube by using a magnetic nanoparticles surface-modified with an amine group and the like selectively binded to a carboxyl group of a semiconducting carbon nanotube. It is possible to separate carbon nanotubes without additional expensive equipment at low cost.

Подробнее
Номер записи: 79
02-09-2010 дата публикации

DEVICE FOR MEASURING DEFORMATION OF STRUCTURES AND A DEFORMATION-MEASURING METHOD FOR STRUCTURES EMPLOYING THE SAME

Номер: WO2010098647A3
Автор: HAAM, Seung Joo, LIM, Yun Mook, LIM, Yoon Cheol, PARK, JoSeph
Принадлежит:

The present invention relates to a device for measuring deformation ratios of structures and to a deformation-ratio-measuring method for structures employing the same. More specifically, the device for measuring deformation ratios of structures of the present invention comprises a photonic crystal layer containing nanoparticles disposed at predetermined intervals. According to the present invention, when diverse industrial structures deform due to factors such as loading in use, structural colour changes or magnetic changes in the affected portion are measured such that accurate measurements can be taken of whether or not deformation has occurred and of the deformation ratio in a way which is straightforward and easy, and these measurements can be used to prevent safety incidents from occurring due to excessive deformation of structures.

Подробнее
Номер записи: 80
01-10-2015 дата публикации

Polymer hydrogel complex and method for the preparation thereof

Номер: KR0101555764B1
Автор: 양재문, 허용민, 서진석, 정재호, 박은성, 함승주, 구민희, 박정민
Принадлежит: 연세대학교 산학협력단

... 본 발명은 고분자 하이드로겔 복합체 및 이의 제조방법에 관한 것으로, 더욱 상세하게는 바이오마커를 표적화 할 수 있고 개질되지 않은 음이온성 다당류 및 형광물질과 공유결합된 양이온성 고분자를 포함하는 근적외선 영역 활성화 영상진단용 고분자 하이드로겔 복합체, 이의 제조방법 및 이의 용도에 관한 것이다.

Подробнее
Номер записи: 81
07-12-2015 дата публикации

OPTICAL PROBE

Номер: KR1020150136293A
Автор: YANG, JAE MOON, HONG, YOO CHAN, LEE, EU GENE, SUH, JIN SUCK, HAAM, SEUNG JOO, CHOI, JI HYE
Принадлежит:

According to an embodiment of the present invention, an optical probe comprises polysaccharides and a conjugated polymer. The optical probe is harmless to the human body, without using a surfactant which has strong cytotoxicity, and without using a metal of a method for colorimetric determination. The optical probe is capable of targeting a malignant tumor, and qualitatively and quantitatively analyzing the malignant tumor with high efficiency by representing a different color with respect to the degree of malignant tumor progression. In addition, the optical probe can perform light and heat treatment only of malignant tumor, without damage to normal cells. COPYRIGHT KIPO 2016 ...

Подробнее
Номер записи: 82