Application of sodium houttuyfonate as synergist of antifungal medicament

The invention relates to the technical field of medicaments, in particular to novel application of sodium houttuyfonate as a synergist of an antifungal medicament. The antifungal medicament is an azole or polyene antifungal medicament; and 1 to 16mu g of sodium houttuyfonate is added into each 1ml of antifungal medicament. Experiments prove that: when the sodium houttuyfonate is combined with the antifungal medicament such as fluconazole, ketoconazole, miconazole or amphotercin B, and the like, the treatment effect of the sodium houttuyfonate on superficial or deep fungal infection can be ensured under the condition of reducing the dosage and the sodium houttuyfonate can make the antifungal medicament recover the effect on medicament-resistant fungi, so the sodium houttuyfonate can be used as the synergist of the antifungal medicament. The sodium houttuyfonate serving as the synergist of the antifungal medicament can reduce the dosage of the azole or polyene antifungal medicament so as ...

Use of shikonin as antifungal medicine synergist

The invention relates to the field of medicine technology and is especially new use of shikonin as an antifungal medicine synergist. The antifungal medicine comprises azole or polyene antifungal medicine and the like, the charge of shikonin is 1-16 mu g/ml in the antifungal medicine. Experiments show that when shikonin is used with the antifungal medicines such as fluconazole, ketoconazole, miconazole or amphotericin B and the like, the treatment effect of superfacial or deep fungal infection can be ensured under the circumstances of reduction of dosage, and the effects of the antifungal medicines to resistant fungi are recovered, thereby that shikonin can be used as antifungal medicine synergist with the advantages of reducing dosages of azole or polyene antifungal medicine so as to reduce side effects of medicines, especially recovering the effects of the antifungal medicines to resistant fungi to treat resistant fungal infection, and having important clinical application value.

Application of sodium houttuyfonate as synergist of antifungal medicament

The invention relates to the technical field of medicaments, in particular to novel application of sodium houttuyfonate as a synergist of an antifungal medicament. The antifungal medicament is an azole or polyene antifungal medicament; and 1 to 16mu g of sodium houttuyfonate is added into each 1ml of antifungal medicament. Experiments prove that: when the sodium houttuyfonate is combined with theantifungal medicament such as fluconazole, ketoconazole, miconazole or amphotercin B, and the like, the treatment effect of the sodium houttuyfonate on superficial or deep fungal infection can be ensured under the condition of reducing the dosage and the sodium houttuyfonate can make the antifungal medicament recover the effect on medicament-resistant fungi, so the sodium houttuyfonate can be used as the synergist of the antifungal medicament. The sodium houttuyfonate serving as the synergist of the antifungal medicament can reduce the dosage of the azole or polyene antifungal medicament so as to ...

Method for similarity identification of expired drugs based on Raman spectroscopy

The invention relates to expired drugs, and in particular, relates to a method for identification of the expired drugs based on Raman spectroscopy. Raman spectra simulating a positive sample and a negative sample are subjected to a certain pre-processing method to eliminate interference of noise, stray light and fluorescence background, a similarity HQI value of two spectra is characterized by calculating two spectra vectorial included angle cosines and related coefficients, then the effectiveness of the method is evaluated by an ROC curve establishing method, a best similarity calculation method, a spectral pre-processing method and identification thresholds are selected, and thus the method for identification of the authenticity of a batch of drugs is established. The rapid and accurate detection analysis of expired drugs counterfeiting the batch of drugs is achieved.

Compound for preventing and treating radiation injuries, single crystal as well as preparation method and application thereof

The invention relates to a compound for preventing and treating radiation injuries, a single crystal as well as a preparation method and application thereof. The chemical structure of the compound is shown in a formula I specified in the description, a pharmacological activity test and an overall animal test prove that the compound in the formula I has good activity, especially the result of the overall animal test shows that the compound in the formula I has great anti-radiation activity and low toxicity, and therefore can be used for reducing the hematopoietic function injuries caused by radioactive or chemotherapeutic medicines, increasing the levels of blood cells, or carrying out adjuvant therapy for tumours. The single crystal of the compound in the formula I is further prepared from the compound disclosed by the invention, and is excellent in stability.

Detection method of generic drugs pretending original drugs

The invention provides a detection method of generic drugs pretending original drugs. The detection method comprises the following five steps: 1, acquiring Raman spectrum data of a sample to be detected; 2, calculating an HQI value of the sample to be detected according to standard Raman spectrum data of the original drugs and the Raman spectrum data of the sample to be detected, and carrying out first judgment on the sample to be detected according to the HQI value; 3, selecting characteristic peaks of the sample to be detected and characteristic peaks of the original drugs; 4, calculating a ratio t of the quantity of the characteristic peaks of the sample to be detected to the quantity of the characteristic peaks of the original drugs, and carrying out second judgment on the sample to be detected according to the t; and 5, calculating a ratio s of the quantity of matched characteristic peaks to the quantity of the characteristic peaks of the original drugs, and carrying out third judgment ...

Fake medicine discrimination and analysis device, system and method

The invention relates to a fake medicine discrimination and analysis device, a fake medicine analysis system containing the fake medicine discrimination and analysis device and a fake medicine analysis method. The fake medicine analysis method of the invention adopts model-free analysis method, makes an improvement on the basis of the already existing local linear screening method to ensure the method to be more stable and reasonable and combines with major constituent analysis method to form an integral fake medicine discrimination system. The fake medicine discrimination and analysis device, fake medicine analysis system and fake medicine analysis method of the invention only require the spectrum of a compound to be tested and few genuine tablets so as to realize fast and convenient discrimination of the tablets to be tested.

Method for detecting ephedrine additives doped in weight-losing traditional Chinese medicines

The invention discloses a method for detecting ephedrine additives doped in weight-losing traditional Chinese medicines. The method comprises the following steps: carrying out thin layer chromatography on weight-losing traditional Chinese medicines to be detected; dropwise adding a surface reinforcing agent at the four positions with Rf values being 0.30-0.33, 0.34-0.36, 0.37-0.39 and 0.50-0.53, and scanning the four positions by adopting a portable raman spectrometer to obtain four original surface enhanced raman spectrograms, when the four original surface enhanced raman spectrograms are blank spectrograms, determining that the weight-losing traditional Chinese medicines to be detected do not contain ephedrine additives, and when the four original surface enhanced raman spectrograms contain non-blank spectrograms, processing the non-blank spectrograms to obtain preprocessed surface enhanced raman spectrograms; and when the preprocessed surface enhanced raman spectrograms contain at least ...

Application of mangiferin as synergist of antifungal agents

Application of schisandrin b and schizandrin c in preparation of anti-hepatic fibrosis drug

The invention relates to the technical field of medicines; the main characteristic component of schisandra chinensis as the traditional Chinese medicine is a lignan component; the lignan component comprises schisandrin a, schisandrin b, schisandrin c and the like; and modern pharmacological tests prove that the lignan component has multiple pharmacological activities for protecting liver, resisting oxidization and the like. The invention provides novel medical application of schisandrin b and schizandrin c, and in particular provides application of schisandrin b and schizandrin c in preparation of an anti-hepatic fibrosis drug. Pharmacodynamics researches show that schisandrin b and schizandrin c can be used for obviously reducing the concentration of ALT (Alanine Aminotransferase) and AST (Aspartate Transaminase) in rat serum of a hepatic fibrosis model induced by common bile duct ligation and CCL4 and improving hepatic fibrosis symptoms, and have good anti-hepatic fibrosis activity; and ...

Method for identifying whether blood-glucose-lowering traditional Chinese medicine contains pioglitazone or rosiglitazone or not

The invention provides a method for identifying whether a blood-glucose-lowering traditional Chinese medicine contains pioglitazone or rosiglitazone or not. The method comprises the following steps: carrying out thin layer chromatography on a blood-glucose-lowering traditional Chinese medicine to be detected; finding a suspected spot at a corresponding Rf value part of the pioglitazone and the rosiglitazone. The method is characterized by further comprising the following three steps: 1, collecting a series of one-dimensional surface enhanced Raman spectrums of the suspected spot to obtain a dynamic spectrum pattern of the blood-glucose-lowering traditional Chinese medicine to be detected; 2, pre-treating the dynamic spectrum pattern and drawing to obtain a two-dimensional correlation surface enhanced Raman spectrum of the blood-glucose-lowering traditional Chinese medicine to be detected; 3, judging whether the blood-glucose-lowering traditional Chinese medicine contains the pioglitazone ...

Acquisition method of surface enhanced Raman two-dimensional correlation spectrum

The invention relates to an acquisition method of a surface enhanced Raman two-dimensional correlation spectrum. According to the method, a dynamic spectrogram of a sample to be tested is acquired through a Raman spectrometer, and the dynamic spectrogram is processed through spectrogram processing software to obtain the surface enhanced Raman two-dimensional correlation spectrum. The acquisition method of the surface enhanced Raman two-dimensional correlation spectrum is characterized in that the acquisition of the dynamic spectrogram includes the following two steps that first, the sample is prepared, and a site to be tested is marked; second, the laser intensity of the Raman spectrometer is set, the site to be tested is continuously irradiated to be infinitesimally disturbed by the laser of the Raman spectrometer at the laser intensity, a series of one-dimensional surface enhanced Raman spectrums of the site to be tested are acquired at the same time, and the dynamic spectrogram of the ...

Rapid detection method of drugs with weak main drug signal

The invention provides a rapid detection method of drugs with a weak main drug signal. The rapid detection method comprises the following steps: determining a drug with a weak main drug signal; preparing a sample solution, a standard solution, and a structural analog standard solution; carrying out in-situ detection on speckles on a lamella after sample application; and calculating the rf value of TLC (thin layer chromatograph) expansion. The provided rapid detection method can carry out rapid detection on drugs, which have a structural analog and a weak main drug signal, so as to judge authenticity and quality of the drugs.

Traditional Chinese medicine extract composition used for treating cardiovascular diseases and preparation method thereof

The invention relates to a traditional Chinese medicine extract composition used for treating cardiovascular diseases and a preparation method thereof. Under the guidance of theories of the traditional Chinese medicine, methods for preparing all the active ingredients, including prepared common monkshood daughter root, dried ginger and liquorice root, in a Sini decoction component and a compatibility and combination proportion are provided. Pharmacodynamic tests show that the composition of the extracts of all the medicines in the Sini decoction can achieve the effects of increasing the ejection fractions and fractional shortening of rats with heart failures caused by myocardial infarction, obviously improving cardiomyocyte morphologies, reducing the degree of cardiac collagen fibrosis and reducing the contents of aldosterone and atrial natriuretic peptide in serums, and has the function of treating cardiovascular diseases. The composition has definite pharmacodynamic effects, is rigorous ...

Edge planer knife rest frock

The utility model discloses an edge planer knife rest frock, including the knife rest, be provided with sword row in the knife rest, sword row is I -shapedly, is provided with two clamping groove, the two the clamping inslot is equallyd divide and do not is provided with the planer tool. Can two planer tools of clamping in I -shaped sword is arranged, a depth of cut of cutter can reach 0.6mm, and cutter traditional has relatively shortened process time greatly, has improved machining efficiency.

氟代羧烷基环糊精醚类化合物及其制备方法和应用

The invention discloses a fluorocarboxyalkyl cyclodextrin ether compound and its preparing method and application. Its preparing method: on condition of alkali, mixing halogenated and fluoro alkyl carboxylic acid with mother body cyclodextrin in a solvent, adding in acid to obtain a mixed solution containing fluorocarboxyalkyl cyclodextrin ether and mixing the mixed solution with reacting substance, so as to obtain the compound at once; the preparing process is simple and easy to control and operate, the production cost is low to be beneficial to spread and apply. As acting as medicine dressing, it can extremely improve the solubility of medicine in solution, obviously enhancing the stability of medicine; as acting as chiral assistant, can be applied to capillary electrophoresis, gas chromatography, etc to separate chiral compounds, the operation is simple, the separating size is high and the separation cost is low. In addition, it can also be used in preparing pesticides, organic wastes ...

Natural medicine composition used for treating cardiovascular diseases

The invention relates to a natural medicine composition used for treating cardiovascular diseases. The natural medicine composition comprises aconitine, liquiritin and 6-gingerol and is prepared into oral preparations, such as hard capsules, soft capsules, tablets, granules, powder, pills, tea bags and medicinal liquor by utilizing synergistic effects of the components. The composition can achieve the effects of treating rats with heart failures caused by myocardial infarction, increasing the ejection fractions and fractional shortening of the rats, obviously improving cardiomyocyte morphologies, reducing the degree of cardiac collagen fibrosis and reducing the contents of aldosterone and atrial natriuretic peptide in serums, and has the function of treating cardiovascular diseases. The composition has definite pharmacodynamic effects, is rigorous in quality control and small in taking dosage and is convenient to take.

Preparation process of anti-tumor active constituent of compound Chinese medicine 'Yi Yi Fu Zi Bai Jiang San'

Method for detecting generic drug pretended to be reference listed drug

A method for detecting a generic drug pretended to be an reference listed drug comprises the following steps: step 1, obtaining reference listed drug standard spectral data and to-be-measured sample spectral data; step 2, choosing reference listed drug characteristic peaks and to-be-measured sample characteristic peaks; step three, screening matched characteristic peaks in the to-be-measured sample characteristic peaks conforming to matching conditions, and calculating the number of the matched characteristic peaks; and step four, comparing a difference value between the number of the reference listed drug characteristic peaks and the number of the matched characteristic peaks with a predetermined standard threshold t, when the difference value is less than or equal to t, judging a to-be-measured sample to be a real drug, and when the difference value is greater than t, judging the to-be-measured sample to be a fake drug, wherein t is an arbitrary integer value of 1-10. According to the ...

Method for judging whether traditional Chinese medicines or traditional Chinese medicine decoction pieces are dyed or not

The invention provides a method for judging whether traditional Chinese medicines or traditional Chinese medicine decoction pieces are dyed or not. The method is implemented in a Raman spectrometer, and is characterized by comprising the four steps of 1, dripping a solvent onto the traditional Chinese medicine to be detected, and standing still for a certain time to enable the to-be-detected traditional Chinese medicine to be wetted; 2, putting a dry swab on the traditional Chinese medicine to be detected, pressing the swab to enable the swab to be completely in contact with a part where the solvent is dripped, transferring the solution on the surface of the traditional Chinese medicine to be detected onto the swab, taking down the swab, and marking the position, in contact with the part where the solvent is dripped, of the swab to be a sampling area; 3, detecting the sampling area by the Raman spectrometer to obtain a Raman spectrum; and 4, judging whether the traditional Chinese medicine ...

Biological chromatography comparing and screening system and application thereof

The invention relates to the technical field of analytic chemistry and biological chemistry. The invention provides a biological chromatography comparing and screening system which is an on-line column switching full two-dimensional chromatographic system. The biological chromatography comparing and screening system is composed of three high-performance liquid chromatography solvent conveying pumps, a six-position column switching valve, a two-position ten-way valve, two quantitative loops, a plurality of biological chromatographic columns and a monolithic column tandem mass spectrum analyzer. The biological chromatography comparing and screening system is used for performing parallel comparison on the affinity of micro-molecules on biological chromatography of normal and pathological tissues or cell sources, so as to screen disease targeting active components in a complicated sample. The invention further provides a biological chromatography comparing and screening method using the screening ...

Schisandra chinensis alcohol extract and application thereof to prepare anti-hepatic fibrosis medicine

The invention relates to the technical field of a medicine. The invention provides a schisandra chinensis alcohol extract, an extraction method thereof, and an application of the schisandra chinensis alcohol extract to prepare an anti-hepatic fibrosis medicine. The invention provides a novel medical application of the schisandra chinensis alcohol extract. According to pharmacodynamics study, it is shown that the schisandra chinensis alcohol extract can obviously lower the concentrations of ALT and AST in serum of a mouse, improves the symptom of hepatic fibrosis, and has excellent anti-hepatic fibrosis activity. Therefore, the anti-hepatic fibrosis is applicable to prepare the anti-hepatic fibrosis medicine or a health-care food.

Fake medicine discrimination and analysis device, system and method

The invention relates to a fake medicine discrimination and analysis device, a fake medicine analysis system containing the fake medicine discrimination and analysis device and a fake medicine analysis method. The fake medicine analysis method of the invention adopts model-free analysis method, makes an improvement on the basis of the already existing local linear screening method to ensure the method to be more stable and reasonable and combines with major constituent analysis method to form an integral fake medicine discrimination system. The fake medicine discrimination and analysis device, fake medicine analysis system and fake medicine analysis method of the invention only require the spectrum of a compound to be tested and few genuine tablets so as to realize fast and convenient discrimination of the tablets to be tested.

Compound (2S)-5, 7.2', 6'-tetrahydroxy-6,8-diiso pentenyl-dihydro flavone extracting process and its use

Method for identifying non-developing substances on thin layer plate by using surface-enhanced Raman spectrum

The invention provides a method for identifying non-developing substances on a thin layer plate by using a surface-enhanced Raman spectrum. After substances to be detected are separated by the thin layer plate, a Raman spectrograph is used for scanning the thin layer plate. The method is characterized in that a vertical mark from a sample application spot on the thin layer plate to the front edge of a solvent is marked as a detection line, and a surface enhancing agent is dropwise added onto the sample application spot; the Raman spectrograph is used for scanning point by point along the detection line from the sample application spot and the scanning is performed for one time every m millimeters and is stopped after n times; the surface enhancing agent is dropwise added once at a scanning stopping part; after the dripping is finished, the Raman spectrograph is used for continually scanning for one time every m millimeters, and the scanning is suspended after n times; after the surface ...