05-09-2013 дата публикации
Номер: US20130230877A1
Methods are provided for identifying biomarker proteins that exhibit differential expression in subjects with a first lung condition versus healthy subjects or subjects with a second lung condition. Also provided are compositions comprising these biomarker proteins and methods of using these biomarker proteins or panels thereof to diagnose, classify, and monitor various lung conditions. The methods and compositions provided herein may be used to diagnose or classify a subject as having lung cancer or a non-cancerous condition, and to distinguish between different types of cancer (e.g., malignant versus benign, SCLC versus NSCLC) 1. A method of determining the likelihood that a lung condition in a subject is cancer , comprising:(a) measuring an abundance of a panel of proteins in a sample obtained from the subject, wherein said panel comprises at least 3 proteins selected from the group consisting of ALDOA, FRIL, LG3BP, IBP3, LRP1, ISLR, TSP1, COIA1, GRP78, TETN, PRDX1 and CD14;(b) calculating a probability of cancer score based on the protein measurements of step (a); and(c) ruling out cancer for the subject if the score in step (b) is lower than a pre-determined score.2. The method of claim 1 , wherein said panel further comprises at least one protein selected from the group consisting of BGH3 claim 1 , FIBA and GSLG1.3. The method of claim 1 , wherein said panel comprises at least 4 proteins.4. The method of claim 3 , wherein said panel comprises LRP1 claim 3 , COIA1 claim 3 , ALDOA claim 3 , and LG3BP.5. The method of claim 1 , wherein said panel comprises LRP1 claim 1 , COIA1 claim 1 , ALDOA claim 1 , LG3BP claim 1 , BGH3 claim 1 , PRDX1 claim 1 , TETN claim 1 , and ISLR.6. The method of claim 1 , wherein said panel comprises LRP1 claim 1 , COIA1 claim 1 , ALDOA claim 1 , LG3BP claim 1 , BGH3 claim 1 , PRDX1 claim 1 , TETN claim 1 , ISLR claim 1 , TSP1 claim 1 , GRP78 claim 1 , FRIL claim 1 , FIBA and GSLG1.7. The method of claim 1 , wherein when cancer is ruled ...
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