01-03-2012 дата публикации
Номер: US20120053192A1
This present invention discloses a heterocyclic substituted acardite derivate and application thereof, namely compounds in the general formula (1) or the general formula (2) or pharmaceutically acceptable salts thereof, wherein A is monosubstituted or polysubstituted quinoline, isoquinoline, quinazoline, pyrrole or pyrimidine, and the substituent is halogen, Calkyl, Chaloalkyl, Calkoxy, Chaloalkoxy, Calkylamino, Chaloalkylamino, amino or nitryl; Ris Calkyl; Ris one or more selected from hydrogen, halogen, alkyl, alkoxy, haloalkyl or haloalkoxy; and Ris one or more selected from hydrogen, halogen, alkyl, alkoxy, haloalkyl or haloalkoxy. The compound of the present invention and the pharmaceutically acceptable salt thereof can be used for treating tumor or leukemia. 2. The compound or pharmaceutically acceptable salts thereof according to claim 1 , wherein A is monosubstituted or polysubstituted quinazoline claim 1 , pyrrole or pyrimidine claim 1 , and the substituent is halogen claim 1 , Calkyl claim 1 , Chaloalkyl claim 1 , Calkoxy claim 1 , Chaloalkoxy claim 1 , Calkylamino claim 1 , Chaloalkylamino claim 1 , amino or nitryl.3. The compound or pharmaceutically acceptable salts thereof according to claim 2 , wherein{'sub': 1-5', '1-5', '1-5', '1-5, 'A is monosubstituted or polysubstituted quinazoline, and the substituent is halogen, Calkyl, Chaloalkyl, Calkoxy, Chaloalkoxy, amino or nitryl.'}4. The compound or pharmaceutically acceptable salts thereof according to claim 1 , wherein Ris methyl or ethyl claim 1 , propyl claim 1 , isopropyl.5. The compound or pharmaceutically acceptable salts thereof according to claim 1 , wherein Ris one or more selected from hydrogen claim 1 , halogen claim 1 , Calkyl claim 1 , Calkoxy or Chaloalkyl.6. The compound or pharmaceutically acceptable salts thereof according to claim 5 , wherein Ris one or more selected from H claim 5 , Cl claim 5 , Br claim 5 , F claim 5 , methoxy claim 5 , ethoxy claim 5 , propoxy claim 5 , methyl claim ...
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