26-11-2020 дата публикации
Номер: US20200368221A1
A solid particle, a preparation method therefor, and a pharmaceutical composition. The solid particle comprises a porous solid particle and a non-aqueous liquid formula. The non-aqueous liquid formula comprises 0.10-4.00 wt % of a hydrophobic active pharmaceutical agent, 28.00-99.90 wt % of a hydrophobic solubilizing solution, 0-70.00 wt % of a non-ionic surfactant, and 0-1.00 wt % of an antioxidant. The hydrophobic solubilizing solution comprises a medium-chain monoglyceride and diglyceride, and/or a propylene glycol fatty acid monoester. 1. A solid microparticle , which comprises porous solid particles and a non-aqueous liquid formula , the non-aqueous liquid formula comprises 0.10% to 4.00% hydrophobic active pharmaceutical ingredient , 28.00% to 99.90% hydrophobic liquid solubilizer , 0 to 70.00% nonionic surfactant , and 0 to 1.00% antioxidant , the percentages refer to the weight percentages accounting for the non-aqueous liquid formula; and the hydrophobic liquid solubilizer comprises medium-chain mono-/di-glyceride , and/or propylene glycol fatty acid monoester.2. The solid microparticle as claimed in claim 1 , wherein the content of the hydrophobic active pharmaceutical ingredient is 0.10% to 2.00% or 0.18% to 2.00% claim 1 , and the percentages refer to the weight percentages accounting for the non-aqueous liquid formula;and/or, the content of the hydrophobic liquid solubilizer is 32.50% to 99.07%, 39.60% to 99.01%, or 49.50% to 74.26%, and the percentages refer to the weight percentages accounting for the non-aqueous liquid formula;and/or, when the content of the nonionic surfactant is not 0, the content of the nonionic surfactant is 15.00% to 66.67%, 24.51% to 59.41%, or 24.75% to 49.50%, and the percentages refer to the weight percentages accounting for the non-aqueous liquid formula;and/or, when the content of the antioxidant is not 0, the content of the antioxidant is 0.10% to 1.00% or 0.17% to 0.83%, and the percentages refer to the weight ...
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