STABILIZATION OF TRIS(2 HYDROXYETHYL)METHYLAMMONIUM HYDROXIDE AGAINST DECOMPOSITION WITH DIALKYHYDROXYLAMINE

The invention provides stabilized solutions useful as raw materials in various applications and methods for stabilizing such aqueous solutions with a stabilizer comprising one or more dialkylhydroxylamines or inorganic or organic acid salts thereof. Stabilized solutions and methods for stabilizing aqueous solutions thereof, include, for example, those of tris(2-hydroxy ethyl)methylammonium hydroxide (THEMAH) and/or carbohydrazide (CHZ). 1. A method for stabilizing an aqueous solution of tris(2-hydroxyethyl)methylammonium hydroxide (THEMAH) comprising adding a stabilizer comprising one or more dialkylhydroxylamines or inorganic or organic acid salts thereof to the aqueous solution of THEMAH.2. The method of claim 1 , wherein the dialkyhydroxylamine is diethylhydroxylamine (DEHA).3. The method of claim 2 , wherein the weight ratio of THEMAH to DEHA is from about 0.5:1 to about 50:1.4. The method of claim 2 , wherein the weight ratio of THEMAH to DEHA is from about 1:1 to about 33:1.5. The method of claim 2 , wherein the weight ratio of THEMAH to DEHA is from about 1.7:1 to about 25:1.6. The method of claim 2 , wherein the weight ratio of THEMAH to DEHA is from about 3:1 to about 10:1.7. The method of claim 1 , wherein the inorganic or organic salts are one or more of nitrate claim 1 , phosphate claim 1 , acetate claim 1 , sulfate claim 1 , hydrochloride claim 1 , lactate claim 1 , and glycolate.8. The method of claim 1 , wherein the amount of THEMAH is from about 0.01 wt. % to about 48 wt. %.9. The method of claim 1 , wherein the amount of DEHA is from about 0.003 wt. % to about 5 wt. %.10. The method of claim 1 , wherein the solution further comprises carbohydrazide (CHZ).11. The method of claim 10 , wherein the amount of CHZ is from about 0.02 wt. % to about 12 wt. %.1214-. (canceled)15. A stabilized tris(2-hydroxyethyl)methylammonium hydroxide (THEMAH) solution comprising:THEMAH;water; andstabilizer comprising one or more dialkylhydroxylamines or inorganic or ...

ADDITIVE FOR IMPROVING OPTICAL PERFORMANCE OF AN ELECTROPHORETIC DISPLAY

The present invention is directed to an electrophoretic fluid comprising uncharged or lightly charged neutral buoyancy particles. The resulting fluid can improve not only image stability but also contrast ratio of a display device, without significantly affecting the switching speed. The present invention is also directed to an electrophoretic display comprising display cells filled with the electrophoretic fluid. 1. An electrophoretic fluid comprisingi) a first type of charged pigment particles which are white;ii) a second type of charged pigment particles which have a contrasting color and carry a charge polarity which is opposite of the charge polarity of the first type of charged pigment particles; andiii) uncharged or lightly charged neutral buoyancy particles, all three types of particles are dispersed in a solvent or solvent mixture, wherein the concentration of the uncharged or lightly charged neutral buoyancy particles in the electrophoretic fluid is more than 2.5% by weight, but not exceeding about 25% by weight.2. (canceled)3. The fluid of claim 1 , wherein the second type of charged pigment particles are black.4. The fluid of claim 1 , wherein the uncharged or lightly charged neutral buoyancy particles have the same color as one of the two types of charged pigment particles.5. The fluid of claim 1 , wherein the uncharged or lightly charged neutral buoyancy particles have a color different from either one of the two types of charged pigment particles.6. (canceled)7. The fluid of claim 1 , wherein the lightly charged neutral buoyancy particles carry a charge which is less than 50% of the average charge carried by the first or second type of charged pigment particles.8. The fluid of claim 1 , wherein the lightly charged neutral buoyancy particles carry a charge which is less than 25% of the average charge carried by the first or second type of charged pigment particles.9. The fluid of claim 1 , wherein the lightly charged neutral buoyancy particles carry a ...

Electrophoretic display fluid

The invention is directed to an electrophoretic fluid which can improve display performance such as switching speed, vertical bistability and the ghosting effect, and also reduce display defects. The electrophoretic fluid comprises charged pigment particles dispersed in a mixture of isoparaffins.

SHUTTER MODE FOR COLOR DISPLAY DEVICES

The present invention is directed to a color display comprising an electrophoretic fluid which comprises one or two types of pigment particles dispersed in a clear and colorless or clear and colored solvent, wherein said electrophoretic fluid is sandwiched between a common electrode and a plurality of driving electrodes. The driving electrodes are kept at a certain distance in order to expose a background layer. 1. A display device comprising a sub-pixel or pixel , which comprisesa) a display fluid sandwiched between a first layer comprising a common electrode and a second layer comprising multiple driving electrodes; andb) optionally a background layer,wherein exposed area in the sub-pixel or pixel is at least about 30% of the area of the sub-pixel or pixel.2. The device of claim 1 , wherein the exposed area is at least about 50%.3. The device of claim 2 , wherein the exposed area is at least about 70%.4. The device of claim 1 , wherein said driving electrodes comprise driving electrode of a first size and driving electrode of a second size.5. The device of claim 4 , wherein the first size is the same as the second size.6. The device of claim 4 , wherein the ratio of area of the driving electrode of the first size to the area of the driving electrode of the second size is 1.5:1 to 10:1.7. The device of claim 6 , wherein the ratio of area of the driving electrode of the first size to the area of the driving electrode of the second size is 2:1 to 4:1.8. The device of claim 1 , wherein the display fluid comprises one type of charged pigment particles dispersed in a solvent or solvent mixture.9. The device of claim 1 , wherein the display fluid comprises two types of charged pigment particles dispersed in a solvent or solvent mixture claim 1 , wherein the two types of charged pigment particles carry opposite charge polarities and are of contrasting colors.10. The device of claim 9 , wherein the two types of charged pigment particles are black and white claim 9 , ...

Self-aligned fibrous scaffolds for automechanoinduction of cell cultures

Self-aligned fibrous scaffolds are disclosed. The scaffolds are capable of automechanoinduction of cell cultures and methods to induce authomechanoinduction in cancer cells and stem cells are disclosed as well. 1. A biocompatible scaffold for multi-dimensional cultivation of cells , said scaffolds capable of automechanoinduction and comprising:highly aligned fibers oriented to form a scaffold with open porosity for the cultured cells, wherein the fibers have a diameter of 5-100 nm, and an aspect ratio more than 10000:1,said fibers being made of non-cytotoxic, non-carcinogenic inorganic metal oxide, andsaid fibers being self-aligned into the scaffold during its manufacturing process.2. The scaffold according to claim 1 , wherein the open porosity is in a range of 70-99%.3. The scaffold according to claim 2 , wherein the open porosity is 85-95%.4. The scaffold according to claim 1 , wherein the fibers have a length of 10-20 mm.5. The scaffold according to claim 1 , wherein the diameter of the fibers is 20-50 nm.6. The scaffold according to claim 1 , wherein the fibers have aspect ratio more than 20000:1.7. The scaffold according to claim 1 , wherein the fibers are coated with a bioinert material.8. The scaffold according to claim 7 , wherein the bioinert material is non-functionalized graphene.9. The scaffold according to claim 1 , wherein the metal oxide is selected from the group consisting of silica claim 1 , titania claim 1 , zirconia and alumina.10. The scaffold of according to claim 9 , wherein the fibers are of aluminum oxide.11. The scaffold of claim 1 , wherein the scaffold is for cultivation of stem cells and the scaffold is capable of inducing automechanoinduction of neural differentiation of the stem cells.12. The scaffold of claim 1 , wherein the scaffold is for cultivation of cancer cells and the scaffold is capable of inducing automechanoinduction of gene expressions in the cancer cells to make them suitable as tumor models.13. A method to induce ...

HIGH AFFINITY AND AGGREGATIVELY STABLE ANTIBODIES ON THE BASIS OF VARIABLE DOMAINS VL AND A DERIVATIVE VHH

The monoclonal IgG-type antibodies were suggested comprising variable domains represented by a combination of VHH-derivative with a variable domain of the light chain V. Said antibodies can comprise amino acid substitutions at positions 44 and 45 (Kabat numbering) or combinations thereof. Antibodies of the invention possess increased affinity and improved aggregation stability. 124-. (canceled)25. A method for treatment of an IL-17A-mediated disease or disorder , comprising administering to a patient in need thereof a therapeutically effective amount of an antibody or a fragment thereof that specifically binds to human IL-17A comprising a heavy chain variable domain V , and a light chain variable domain Vcomprising the amino acid sequence of SEQ ID NO: 8 , wherein the Vcomprises:a) HCDR1, HCDR2 and HCDR3 comprising the amino acid sequences of SEQ ID NO: 4, SEQ ID NO: 5 and SEQ ID NO: 6, respectively; or [{'sup': 'th', 'the amino acid at the 6position of SEQ ID. NO: 4 is N, K, R, E, W, M, Q, D, F, V, L or A;'}, {'sup': 'th', 'the amino acid at the 7position of SEQ ID. NO: 4 is S;'}, {'sup': 'th', 'the amino acid at the 8position of SEQ ID. NO: 4 is I;'}, {'sup': 'th', 'the amino acid at the 9position of SEQ ID. NO: 4 is L, A, I, S, R, V, N, Q or M;'}, {'sup': 'st', 'the amino acid at the 1position of SEQ ID NO: 5 is G or L;'}, {'sup': 'th', 'the amino acid at the 4position of SEQ ID NO: 5 is A;'}], 'b) a variant of a), comprising one amino acid substitution selected from the group consisting of{'sup': 'th', 'the amino acid at the 7position of SEQ ID NO: 5 is S, R, P, D, I, T, E, K, A, L or W;'}{'sup': 'rd', 'the amino acid at the 3position of SEQ ID NO: 6 is K, S, A, T, D or G;'}{'sup': 'th', 'the amino acid at the 4position of SEQ ID NO: 6 is K;'}{'sup': 'th', 'the amino acid at the 5position of SEQ ID NO: 6 is G, Y, H, D, W or K;'}{'sup': 'th', 'the amino acid at the 6position of SEQ ID NO: 6 is A, V, S, L M or H;'}{'sup': 'th', 'the amino acid at the 8position of ...

MONOCLONAL ANTIBODIES THAT BIND SPECIFICALLY TO HUMAN TRBV9

The invention relates to a monoclonal humanized antibody or antigen-binding fragment thereof that specifically bind to the TRBV9 family of the human T cell receptor. The invention also relates to a nucleic acid encoding said antibody or antigen-binding fragment thereof, an expression vector, a method for preparing said antibody, and use of said antibody in treatment of diseases or disorders associated with the human T cell receptor family. The invention is directed to generation of antibodies that can be used for treating, in particular AS, celiac disease and malignant blood diseases, the pathogenesis of which involves the TRBV9 family TCRs. 1. A monoclonal antibody or antigen-binding fragment thereof that specifically bind to the TRBV-9 family beta-chain region of the human T cell receptor , comprising a heavy chain variable domain , the amino acid sequence of which is shown in SEQ ID No: 16 and a light chain variable domain , the amino acid sequence of which is shown in SEQ ID No: 18.2. A monoclonal antibody according to claim 1 , which includes a heavy chain having the amino acid sequence of SEQ ID No: 20 and a light chain having the amino acid sequence of SEQ ID No: 22.3. A monoclonal antibody according to any of claim 2 , which is a full-length IgG antibody.4. A nucleic acid that encodes a monoclonal antibody or antigen-binding fragment thereof according to any of - claim 2 , wherein the antibody or antigen binding fragment thereof specifically binds to the TRBV9 family beta-chain region of the human T receptor.5. An expression vector containing a nucleic acid according to .6. A method of obtaining a host cell for producing an antibody or antigen-binding fragment thereof according to any of - comprising co-transformation of a cell with a vector according to .7. A host cell for obtaining an antibody or antigen-binding fragment thereof according to any of - comprising a nucleic acid according to .8. A method of obtaining an antibody or antigen-binding fragment ...

PaCas9 nuclease

The present invention relates to the field of biotechnology, molecular biology and medicine, in particular to nuclease enzyme and use thereof. More specifically, the present invention relates to PaCas9 nuclease enzyme. The invention also relates to a nucleic acid encoding said nuclease, a genetic construct, an expression vector, a delivery vector, which comprise said nucleic acid, a liposome comprising said nuclease or nucleic acid encoding said nuclease, a method for producing a nuclease, methods for delivery, and a host cell comprising a nucleic acid encoding said nuclease.

COMPUTER-IMPLEMENTED METHOD FOR PROVIDING A BROWSER CONTEXTUAL ASSISTANT IN A GRAPHICAL USER INTERFACE ON A DISPLAY SCREEN OF AN ELECTRONIC DEVICE

A computer-implemented method for providing a browser contextual assistant on an electronic device, the method comprising: (I) receiving, by a server from the electronic device user-selected information appearing in the graphical user interface; (II) effecting, by the server, a search in a plurality of search verticals in respect of the user-selected information; (III) determining which of the plurality of search verticals is the most relevant search vertical; (IV) rendering a menu element, the menu element selected from menu items and data for inclusion into the browser contextual assistant, the at least one of the menu item and the data being related to the most relevant search vertical; (V) sending, by the server to the electronic device the menu element. 1. A computer-implemented method for providing a graphical element providing a browser contextual assistant in a graphical user interface on a display screen of an electronic device , the electronic device having a user input device , a computer usable information storage medium , and a processor coupled to the display screen , to the user input device , and to the computer usable information storage medium , the processor being configured to have access to computer readable commands , the method comprising:(I) receiving, by a server from the electronic device via a communications network, user-selected information appearing in the graphical user interface the user-selected information appearing in the graphical user interface being part of a web page content displayed on the display screen;(II) effecting, by the server, a search in a plurality of search verticals in respect of the user-selected information to render a plurality of search results;(III) based on an analysis of the plurality of search results, determining, by the server, which of the plurality of search verticals is the most relevant search vertical and determining a query type associated with the user-selected text; selecting, from a list of menu ...

Additive for improving optical performance of an electrophoretic display

The present invention is directed to an electrophoretic fluid which comprises uncharged or lightly charged neutral buoyancy particles. The resulting fluid can improve not only image stability but also contrast ratio of a display device, without significantly affecting the switching speed. The present invention is also directed to an electrophoretic display comprising display cells filled with the electrophoretic fluid.

HIGH AFFINITY AND AGGREGATIVELY STABLE ANTIBODIES ON THE BASIS OF VARIABLE DOMAINS VL AND A DERIVATIVE VHH

The monoclonal IgG-type antibodies were suggested comprising variable domains represented by a combination of VHH-derivative with a variable domain of the light chain V. Said antibodies can comprise amino acid substitutions at positions 44 and 45 (Kabat numbering) or combinations thereof. Antibodies of the invention possess increased affinity and improved aggregation stability. 1. A humanized monoclonal IgG antibody or a fragment thereof wherein the variable domains are represented by a combination of a V-derivative with a variable domain of the light chain V.2. The antibody or the fragment thereof according to claim 1 , wherein the V-derivative comprises the following amino acid substitutions at positions 44X45 X:a) wherein 44X2=G, A, V, S, T;b) wherein 45X3=A, V, T, H;or combinations thereof.3. The antibody or the fragment thereof according to claim 1 , characterized by increased aggregation stability of V-derivative compared to the native VHH antibody isolated from an immunized animal from Camelidae family.4. The antibody or the fragment thereof according to claim 1 , wherein the V-derivative is represented by:a variable domain of the heavy chain isolated from an immunized animal from Camelidae family; ora variable domain of the heavy chain isolated from a non-immunized animal from Camelidae family;{'sub': 2', '3, 'claim-text': c) wherein 44X2=G, A, V, S, T;', 'd) wherein 45X3=A, V, T, H;', 'or combinations thereof., 'and comprises additional amino acid substitutions typical for humans and located at any positions, except for the following substitutions at positions 44X45 X5. The antibody or the fragment thereof according to claim 1 , wherein the variable domain of the light chain Vis a human antibody derivative or a humanized fragment of a mammalian antibody.6. The antibody according to claim 1 , wherein said antibody is IgG1 claim 1 , IgG2 claim 1 , IgG3 or IgG4.7. The antibody according to claim 6 , comprising a non-native modified Fc as a part of IgG.8. The ...

MONOCLONAL ANTIBODY THAT SPECIFICALLY BINDS TO CD20

The present invention relates to biotechnology and provides a monoclonal antibody that specifically binds to CD20. The invention also relates to DNA encoding said antibody, the corresponding expression vectors and methods of production thereof, as well as methods of treatment using said antibody. 1. A monoclonal antibody or antigen-binding fragment thereof that specifically binds to CD20 comprising:1) a heavy chain variable domain comprising an amino acid sequence shown in SEQ ID NO: 2 or SEQ ID NO: 6;2) a light chain variable domain comprising an amino acid sequence shown in SEQ ID NO: 4 or SEQ ID NO: 8.2. A monoclonal antibody or antigen-binding fragment thereof according to claim 1 , wherein:(i) 1) the heavy chain variable domain comprises an amino acid sequence shown in SEQ ID NO: 2; and2) the light chain variable domain comprises an amino acid sequence shown in SEQ ID NO: 4; or(ii) 1) the heavy chain variable domain comprises an amino acid sequence shown in SEQ ID NO: 6; and2) the light chain variable domain comprises an amino acid sequence shown in SEQ ID NO: 8.3. (canceled)4. A monoclonal antibody according to comprising:1) a heavy chain comprising an amino acid sequence shown in SEQ ID NO: 1 or SEQ ID NO: 5;2) a light chain comprising an amino acid sequence shown in SEQ ID NO: 3 or SEQ ID NO: 7.5. A monoclonal antibody according to comprising:(i) 1) a heavy chain comprising an amino acid sequence shown in SEQ ID NO: 1; and2) a light chain comprising an amino acid sequence shown in SEQ ID NO: 3; or(ii) 1) a heavy chain comprising an amino acid sequence shown in SEQ ID NO: 5; and2) a light chain comprising an amino acid sequence shown in SEQ ID NO: 7.6. (canceled)7. A monoclonal antibody according to claim 1 , wherein the antibody that specifically binds to CD20 is a full-length IgG antibody.8. A monoclonal antibody according to claim 7 , wherein the full-length IgG antibody relates to human IgG1 claim 7 , IgG2 claim 7 , IgG3 claim 7 , IgG4 isotype.9. A ...

Seamless Switching from a Linear to a Personalized Video Stream

Method for receiving video streams () from a video server () in a client device (), the video streams comprising a sequence of videos in a binary data format, the method comprising: receiving () a linear video stream () from the video server in the client device; receiving () a switching signal () from the video server in the client device; and in response to the switching signal, switching () from receiving the linear video stream to receiving () a personalized video stream () from the video server in the client device, wherein a last video finishes () before switching to the personalized video stream, wherein the last video is a video that is being received in the linear video stream when the switching signal is received in the client device. 220222020. The method according to claim 1 , wherein the linear stream is broadcast to a plurality of client devices (-) including said client device () claim 1 , and wherein the personalized video stream is unicast to said client device ().3. The method according to any one of the preceding claims claim 1 , wherein the linear video stream comprises a data pattern (P) claim 1 , and wherein the data pattern is detected and used by the client device to determine when the last video finishes.4. The method according to claim 3 , wherein the data pattern is transmitted in between two videos in the linear video stream claim 3 , wherein preferably the data pattern is humanly unperceivable claim 3 , and wherein preferably the data pattern is transmitted in a video channel or an audio channel in the linear video stream.5. The method according to claim 3 , wherein the data pattern comprises characteristic elements within the video that are obtainable through analyzing the video.62001106. The method according to any one of the - claim 3 , wherein the client device transmits a trigger signal () to the video server in response to detection () of the data pattern claim 3 , wherein the switching signal is received in response to the trigger ...

ANTI-IL-17 ANTIBODIES, METHOD FOR PRODUCING SAME AND METHOD FOR USING SAME

The present invention relates to the field of medicine, and specifically to the field of monoclonal antibodies against human IL-17. More specifically, the invention relates to monoclonal antibodies/antagonists of IL-17A, which bind with high affinity to an IL-17 epitope, wherein the antibodies contain amino acid substitutions in hypervariable regions of heavy and light chains. The antibodies according to this invention can be chimeric, humanized or human antibodies or antigen-binding fragments thereof, and can be used as a medicinal agent for treating autoimmune and inflammatory disorders and disorders of cell proliferation and development. The invention also relates to methods for producing said antibodies. 1. An isolated monoclonal antibody or fragment thereof specifically binding to human IL-17A containing variable regions of the heavy (VH) and light (VL) chains , wherein: 'F-T-F-S-X31-X32-X33-X34-X35, wherein:', 'HCDR1 comprises the amino acid sequence of SEQ ID NO: 1, 'a) the heavy chain variable region (VH) comprises 3 hypervariable regions HCDR1, HCDR2 and HCDR3, whereinX31 is an amino acid selected from N, D, K, L, P and T;X32 is an amino acid selected from Y and F;X33 is an amino acid selected from A, G, N, S, T and V;X34 is an amino acid selected from M and I; and HCDR2 comprises the amino acid sequence of SEQ ID NO: 2:', 'X50-I-X52-X52a-X52b-X53-G-X55-X56-X57-X58, wherein:, 'X35 is an amino acid selected from S, G, N and T;'}X50 is an amino acid selected from R, G, I, L, M and S;X52 is an amino acid selected from D and E;X52a is an amino acid selected from G and M;X52b is an amino acid selected from G, L, R and V;X53 is an amino acid selected from I and L;X55 is an amino acid selected from S, T, L, R and W;X56 is an amino acid selected from S, T, S and Y;X57 is an amino acid selected from S, T, L, R and W; and 'C-A-X94-X95-Y-X97-X98-X99-X100-X100a, wherein:', 'HCDR3 comprises the amino acid sequence of SEQ ID NO: 3, 'X58 is an amino acid selected from Y, ...

ANTI-PD-1 ANTIBODIES, METHOD FOR PRODUCING SAME AND METHOD FOR USING SAME

The present invention relates to biotechnology and comprises isolated monoclonal antibodies, in particular human monoclonal antibodies, which specifically bind to PD-1 with high affinity. The antibodies according to the invention may be chimeric, humanized or human antibodies, or antigen-binding fragments thereof, and may be used as a medicinal agent in oncology and immuno-oncology, for treating diseases associated with various cell proliferation or development disorders. The invention also relates to methods for producing said antibodies and a method for treating human diseases using said antibodies. 1. An antibody or an antigen binding fragment thereof , having the ability to bind to a human PD-1 receptor , comprising a binding domain that comprises an amino acid sequence that is at least 75% identical to SEQ ID NO: 3.2. (canceled)3. The antibody or fragment thereof according to claim 1 , characterized in that the antibody or fragment thereof contains:a sequence of a heavy chain variable domain that is at least 75% identical to SEQ ID NO:7, anda sequence of a light chain variable domain that is at least 75% identical to SEQ ID NO:8.4. The antibody or fragment thereof according to claim 1 , characterized in that the binding domain comprises the amino acid sequences comprising SEQ ID NOs: 1-3.5. The antibody or fragment thereof according to claim 1 , characterized in that the binding domain competes for binding or binds to the same epitope as the binding domain comprising the amino acid sequence of SEQ ID NO: 7.6. The antibody or fragment thereof according to claim 1 , characterized in that the binding domain is at least 90% identical to SEQ ID NO: 7.7. The antibody or fragment thereof according to claim 1 , characterized in that the binding domain comprises the amino acid sequence of SEQ ID NO: 7.8. The antibody or fragment thereof according to claim 1 , characterized in that the binding domain is humanized.9. The antibody or fragment thereof according to any one ...

ADDITIVE PARTICLES FOR IMPROVING OPTICAL PERFORMANCE OF AN ELECTROPHORETIC DISPLAY

The present invention is directed to an electrophoretic fluid which comprises additive particles. The concentration of the additive particles in the electrophoretic fluid is 2.5% to 25% by weight and the additive particles are not seen at the viewing side during operation of the display. The resulting fluid can improve optical performance of a display device, such as image stability and contrast ratio. The present invention is also directed to an electrophoretic display comprising the electrophoretic fluid. 1. An electrophoretic display comprising an electrophoretic fluid which comprises charged pigment particles and additive particles , wherein the additive particles are uncharged or lightly charged neutral buoyancy particles , all types of particles are dispersed in a solvent or solvent mixture , and the concentration of the uncharged or lightly charged neutral buoyancy particles in the electrophoretic fluid is more than 2.5% by weight , but not exceeding 25% by weight and the additive particles are not seen at the viewing side during operation of the display.2. The display of claim 1 , wherein the uncharged or lightly charged neutral buoyancy particles have the same color as one type of charged pigment particles.3. The display of claim 1 , wherein the uncharged or lightly charged neutral buoyancy particles have a color different from that of the charged pigment particles.4. The display of claim 1 , wherein the uncharged or lightly charged neutral buoyancy particles are formed from a material selected from the group consisting of polyacrylate claim 1 , polymethacrylate claim 1 , polystyrene claim 1 , polyaniline claim 1 , polypyrrole claim 1 , polyphenol and polysiloxane.5. The display of claim 1 , wherein the uncharged or lightly charged neutral buoyancy particles are formed from a material selected from the group consisting of poly(pentabromophenyl methacrylate) claim 1 , poly(2-vinylnapthalene) claim 1 , poly(naphthyl methacrylate) claim 1 , poly(alpha- ...

ELECTROPHORETIC FLUID

The present invention is directed to an electrophoretic fluid comprising transparent particles, as an additive. The presence of the transparent particles in the fluid provides improved display performance. 1. An electrophoretic fluid comprising charged non-transparent particles and transparent particles all of which are dispersed in a solvent , wherein the refractive index of the transparent particles is substantially the same as that of the solvent.2. The fluid of claim 1 , wherein the refractive index is lower than 1.5.3. The fluid of claim 1 , wherein the transparent particles take up less than 20% by volume of the fluid.4. The fluid of claim 1 , wherein the transparent particles take up less than 10% by volume of the fluid.5. The fluid of claim 1 , wherein the transparent particles are formed from an organic material.6. The fluid of claim 1 , wherein the transparent particles are formed from an inorganic material.7. The fluid of claim 5 , wherein the transparent particles are formed from a monomer or oligomer selected from the group consisting of acrylate or methacrylate claim 5 , siloxane modified acrylate or methacrylate claim 5 , and halogenated acrylate or methacrylate.8. The fluid of claim 1 , wherein the transparent particles have an average size of less than 0.5 μm.9. The fluid of claim 1 , wherein the transparent particles have an average size of less than 0.3 μm.10. The fluid of claim 1 , wherein the transparent particles have an average size of less than 0.1 μm.11. The fluid of claim 1 , wherein the non-transparent charged pigment particles are white particles which carry a positive or negative charge polarity.12. The fluid of claim 1 , wherein the non-transparent charged pigment particles are black and white particles carrying opposite charge polarities.13. The fluid of claim 1 , wherein the solvent is a hydrocarbon solvent.14. The fluid of claim 1 , wherein the solvent is halogenated or fluorinated.15. The fluid of claim 1 , wherein the transparent ...

CLEANING COMPOSITION FOLLOWING CMP AND METHODS RELATED THERETO

The invention provides a composition for cleaning contaminants from semiconductor wafers following chemical-mechanical polishing. The cleaning composition contains a bulky protecting ligand, an organic amine, an organic inhibitor, and water. The invention also provides methods for using the cleaning composition. 2. The composition of claim 1 , wherein the contaminants include abrasive particles claim 1 , organic residue claim 1 , metal ions claim 1 , polishing pad debris claim 1 , CMP-byproducts claim 1 , or any combination thereof.3. The composition of or claim 1 , wherein the weight ratio of the bulky protecting ligand(s) to the organic amine(s) is from about 1:1 to about 10:1.4. The composition of claim 3 , wherein the weight ratio of the bulky protecting ligand(s) to the organic amine(s) is from about 1:1 to about 3:1.5. The composition of claim 3 , wherein the weight ratio of the bulky protecting ligand(s) to the organic amine(s) is about 2.5:1.7. The composition of claim 5 , wherein the bulky protecting ligand is a quaternary ammonium hydroxide comprising ammonium hydroxide claim 5 , tetraalkylammonium hydroxide claim 5 , hydroxyalkylammonium hydroxide claim 5 , trihydroxyalkylammonium hydroxide claim 5 , or any combination thereof.8. The composition of claim 5 , wherein the bulky protecting ligand is tetramethylammonium hydroxide (TMAH) claim 5 , tetraethylammonium hydroxide (TEAM) claim 5 , tetrabutylammonium hydroxide (TBAH) claim 5 , cetyltrimetylammonium hydroxide claim 5 , choline hydroxide claim 5 , trihydroxyethylmethylammonium hydroxide (THEMAH) claim 5 , or any combination thereof.9. The composition of claim 5 , wherein the bulky protecting ligand is trihydroxyethylmethylammonium hydroxide (THEMAH).10. The composition of - claim 5 , wherein the bulky protecting ligand is present in an amount of at least about 3 wt. % based on the total weight of the composition.11. The composition of claim 10 , wherein the bulky protecting ligand is present in an ...

DERIVATIZED POLYAMINO ACIDS

A composition comprises, consists of, or consists essentially of a polymer including a derivatized amino acid monomer unit. A chemical mechanical polishing composition includes a water based liquid carrier, abrasive particles dispersed in the liquid carrier, and a cationic polymer having a derivatized amino acid monomer unit. A method of chemical mechanical polishing includes utilizing the chemical mechanical polishing composition to remove at least a portion of a metal or dielectric layer from a substrate and thereby polish the substrate. 1. A chemical mechanical polishing composition comprising:a water based liquid carrier;abrasive particles dispersed in the liquid carrier; anda cationic polymer having a derivatized amino acid monomer unit.2. The composition of claim 1 , wherein the abrasive particles comprise a colloidal silica abrasive having a positive charge of at least 10 mV.3. The composition of claim 1 , wherein the derivatized amino acid monomer unit comprises a derivative group bonded to an alpha amino group in the monomer unit.4. The composition of claim 1 , wherein the cationic polymer comprises at least one of derivatized polylysine claim 1 , derivatized polyarginine claim 1 , and derivatized polyhistidine.5. The composition of claim 4 , wherein the cationic polymer comprises derivatized ε-poly-L-lysine.6. The composition of claim 1 , comprising from about 1 to about 1000 ppm of the cationic polymer.7. The composition of claim 1 , wherein the cationic polymer has an acid dissociation constant (pK) in a range from about 6 to about 11.9. The composition of claim 8 , wherein Rcomprises at least one of an alkyl carbonyl group claim 8 , a divalent carboacyl group claim 8 , an alkyl urea group claim 8 , and an alkyl sulfonate group claim 8 , an alkyl sulfone group claim 8 , and an alkyl ester group.10. The composition of claim 9 , wherein the alkyl carbonyl group comprises at least one of an acetyl group claim 9 , a pivaloyl group claim 9 , and an ethyl ...

COMPOSITION AND METHOD FOR METAL CMP

A chemical mechanical polishing composition for polishing a substrate includes a liquid carrier and cationic metal oxide abrasive particles dispersed in the liquid carrier. The cationic metal oxide abrasive particles have a surface modified with at least one compound consisting of a silyl group having at least one quaternary ammonium group. A method for chemical mechanical polishing a substrate including a metal layer includes contacting the substrate with the above described polishing composition, moving the polishing composition relative to the substrate, and abrading the substrate to remove a portion of the metal layer from the substrate and thereby polish the substrate. 2. The composition of claim 1 , whereinthe silyl group is represented by the general formula (2); and{'sub': 2', '2', '2', '2, 'sup': 1', '2', '+, 'L is —CHCHCHOCH—, Rand Rare H, and A is —NR′R″R′″ wherein R′, R″, and R′″ are the same or different and include substantially any carbon containing compound.'}3. The composition of claim 1 , whereinthe silyl group is represented by the general formula (3); and{'sub': 2', '2, 'sup': '+', 'L is —CHCH— and A′ is —NR′R″R′″ wherein R′, R″, and R′″ are the same or different and include substantially any carbon containing compound.'}4. The composition of claim 1 , wherein the liquid carrier is water.5. The composition of claim 1 , wherein the metal oxide abrasive particles are silica particles.6. The composition of claim 1 , wherein the metal oxide abrasive particles have a mean particle size in a range from about 30 to about 90 nm.7. The composition of claim 1 , having a pH from about 6 to about 8.8. The composition of claim 1 , wherein the cationic metal oxide abrasive particles have an isoelectric point greater than about 9.9. The composition of claim 1 , wherein the cationic metal oxide abrasive particles comprise colloidal silica particles having a zeta potential of at least 20 mV at a pH of greater than 6.10. The composition of claim 1 , comprising ...

COMPOSITION AND METHOD FOR SILICON NITRIDE CMP

The invention provides a chemical-mechanical polishing composition for polishing a silicon nitride containing substrate. The composition includes an aqueous carrier; cationic silica particles dispersed in the aqueous carrier, the cationic silica abrasive particles having a zeta potential of at least 10 mV in the polishing composition; a polishing additive selected from the group consisting of a polyether amine, a polysilamine, a polyvinylimidazole, and a combination thereof, wherein the polyether amine and the polysilamine have corresponding weight average molecular weights of about 1,000 g/mol or less. The composition has a pH of greater than about 6. A method for polishing a silicon nitride containing substrate is also provided. 1. A chemical-mechanical polishing composition for polishing a silicon nitride containing substrate , the polishing composition comprising:an aqueous carrier;cationic silica particles dispersed in the aqueous carrier, the cationic silica abrasive particles having a zeta potential of at least 10 mV in the polishing composition;a polishing additive selected from the group consisting of a polyether amine, a polysilamine, and a combination thereof, wherein the polyether amine and the polysilamine have corresponding weight average molecular weights of less than about 1,000 g/mol, and wherein the polyether amine is a propylene oxide diamine, a propylene oxide triamine, an ethylene oxide/propylene oxide diamine, an ethylene oxide/propylene oxide triamine, or a combination thereof; andwherein the polishing composition has a pH of greater than about 6.2. (canceled)3. The polishing composition of claim 1 , wherein the polishing additive comprises polysilamine having a weight average molecular weight of about 900 g/mol or less.4. The polishing composition of claim 1 , wherein the polishing additive comprises polyether amine having a weight average molecular weight of about 900 g/mol or less.5. (canceled)7. The polishing composition of claim 1 , ...

COMPOSITION AND METHOD FOR COPPER BARRIER CMP

A chemical mechanical polishing composition for polishing a substrate having copper, barrier, and dielectric layers includes a water based liquid carrier, cationic silica abrasive particles dispersed in the liquid carrier, and a triazole compound, wherein the polishing composition has a pH of greater than about 6 and the cationic silica abrasive particles have a zeta potential of at least 10 mV. The triazole compound is not benzotriazole or a benzotriazole compound. A method for chemical mechanical polishing a substrate including copper, barrier, and dielectric layers includes contacting the substrate with the above described polishing composition, moving the polishing composition relative to the substrate, and abrading the substrate to remove a portion of the copper, barrier, and dielectric layers from the substrate and thereby polish the substrate. 1. A chemical mechanical polishing composition for polishing a substrate having copper , barrier , and dielectric layers , the polishing composition comprising:a water based liquid carrier;cationic silica abrasive particles dispersed in the liquid carrier, the cationic silica abrasive particles having a zeta potential of at least 10 mV in the polishing composition;a triazole compound, wherein the triazole compound is not benzotriazole or a benzotriazole compound; andwherein the polishing composition has a pH of greater than 6, and wherein the composition is substantially free of a per-compound oxidizer and further comprises an N-oxide compound oxidizer.2. The composition of claim 1 , wherein the triazole compound is a triazole pyridine compound.3. The composition of claim 2 , wherein the triazole pyridine compound is 1H-1 claim 2 ,2 claim 2 ,3-Triazolo[4 claim 2 ,5 claim 2 ,b] pyridine claim 2 , 1-Acetyl-1H-1 claim 2 ,2 claim 2 ,3-triazolo[4 claim 2 ,5 claim 2 ,b] pyridine claim 2 , 3H-[1 claim 2 ,2 claim 2 ,3]Triazolo[4 claim 2 ,5-c] pyridine claim 2 , or 2-(1 claim 2 ,2 claim 2 ,4-Triazol-3-yl) pyridine.4. The ...

COMPOSITION AND METHOD FOR POLISHING SILICON CARBIDE

The invention provides a chemical-mechanical polishing composition comprising (a) silica particles, (b) a polymer comprising sulfonic acid monomeric units, (c) optionally, a buffering agent, and (d) water, wherein the polishing composition has a pH of about 2 to about 5. The invention further provides a method of chemically-mechanically polishing a substrate with the inventive chemical-mechanical polishing composition. Typically, the substrate comprises silicon carbide and silicon nitride. 1. A method of chemically mechanically polishing a substrate comprising:(i) providing a substrate, wherein the substrate comprises a silicon carbide layer on a surface of the substrate;(ii) providing a polishing pad; '(a) silica particles,', '(iii) providing a polishing composition comprising (c) water,', 'wherein the polishing composition has a pH of about 2 to about 5;, '(b) a polymer comprising sulfonic acid monomeric units selected from polystyrenesulfonic acid, poly(2-acrylamido-2-methyl-l-propanesulfonic acid), and poly(styrenesulfonic acid-co-maleic acid), and has an average molecular weight of about 75,000 g/mole to about 200,000 g/mole, and'}(iv) contacting the substrate with the polishing pad and the polishing composition; and(v) moving the polishing pad and the polishing composition relative to the substrate to abrade at least a portion of the silicon carbide layer on a surface of the substrate to polish the substrate.2. The method of claim 1 , wherein the silica particles comprise aluminum ions claim 1 , and wherein the aluminum ions are uniformly distributed within the silica particles.3. The method of claim 1 , wherein the silica particles have an average particle size of about 40 nm to about 60 nm.4. (canceled)5. (canceled)6. The method of claim 1 , wherein the polymer comprising sulfonic acid monomeric units is polystyrenesulfonic acid.7. The method of claim 1 , wherein the polishing composition further comprises an oxidizing agent.8. The method of claim 1 , ...

CLEANING COMPOSITION AND METHOD FOR CLEANING SEMICONDUCTOR WAFERS AFTER CMP

The invention provides a composition for cleaning contaminants from semiconductor wafers following chemical-mechanical polishing. The cleaning composition contains one or more quaternary ammonium hydroxides, one or more organic amines, one or more metal inhibitors, and water. The invention also provides methods for using the cleaning composition.

Antibody or an antigen-binding fragment thereof capable of binding to a human receptor of interleukin-6

The invention relates to medicine. The problem addressed by the present invention consists in creating alternative antibodies or fragments thereof which are capable of specifically binding to a human receptor of interleukin-6 and which would be useful as drugs for treating or diagnosing diseases, or for relieving symptoms, mediated by interleukin-6.

COMPOSITION FOR TUNGSTEN CMP

A chemical mechanical polishing composition includes a water based liquid carrier, cationic abrasive particles dispersed in the liquid carrier, a first amino acid compound having an isoelectric point of less than 7 and a second amino acid compound having an isoelectric point of greater than 7. The pH of the composition is in a range from about 1 to about 5. A method for chemical mechanical polishing a substrate including a tungsten layer includes contacting the substrate with the above described polishing composition, moving the polishing composition relative to the substrate, and abrading the substrate to remove a portion of the tungsten from the substrate and thereby polish the substrate. 1. A chemical mechanical polishing composition for polishing a substrate having a tungsten layer , the composition comprising:a water based liquid carrier;cationic abrasive particles dispersed in the liquid carrier;a first amino acid compound having an isoelectric point of less than 7;a second amino acid compound having an isoelectric point of greater than 7; anda pH in a range from about 1 to about 5.2. The composition of claim 1 , having a pH in a range from about 3 to about 5.3. The composition of claim 1 , wherein the first amino acid compound is selected from the group consisting of alanine claim 1 , phenylalanine claim 1 , glycine claim 1 , leucine claim 1 , isoleucine claim 1 , proline claim 1 , tyrosine claim 1 , valine claim 1 , glutamic acid claim 1 , and mixtures thereof.4. The composition of claim 1 , wherein the first amino acid compound is selected from glycine claim 1 , valine claim 1 , alanine claim 1 , and mixtures thereof.5. The composition of claim 1 , wherein the second amino acid compound is selected from the group consisting of histidine claim 1 , arginine claim 1 , lysine claim 1 , and mixtures thereof.6. The composition of claim 1 , wherein the first amino acid compound is glycine and the second amino acid compound is arginine.7. The composition of ...

COLOR DISPLAY DEVICE

The present invention is directed to a color display device in which each pixel can display at least five high-quality color states, and an electrophoretic fluid for such an electrophoretic display. In one aspect, the different types of particles exhibit different levels of attraction force to display different color states. In another aspect, the different types of particles exhibit different levels of mobility in different driving voltage ranges to display different color states. 1. An electrophoretic display comprising a first surface on a viewing side , a second surface on a non-viewing side , and an electrophoretic fluid sandwiched between a common electrode at the viewing side and a layer of pixel electrodes and comprising a first type of particles , a second type of particles , a third type of particles , a fourth type of particles and a fifth type of particles , all of which are dispersed in a solvent or solvent mixture , wherein:(a) the five types of pigment particles have optical characteristics differing from one another;(b) the first and second types of particles carry opposite charge polarities;(c) the third and fourth types of particles carry the same charge polarity as the first type of particles, and the first type, the third type and the fourth type of particles have progressively lower magnitudes; and(d) the fifth type of particles carries the same charge polarity as the second type of particles, but their magnitude is lower than that of the second type of particles.2. The display of claim 1 , wherein the first and second types of particles are black and white claim 1 , or vice versa.3. The display of claim 1 , wherein the first and second types of particles are black and yellow claim 1 , or vice versa.4. The display of claim 2 , wherein the first type of particles is black claim 2 , the second type of particles is white claim 2 , and the third claim 2 , fourth and fifth types of particles are red claim 2 , green and blue claim 2 , respectively.5. ...

SYSTEM AND METHOD FOR MANAGING A WEB RESOURCE IN A BROWSER APPLICATION

There is disclosed a method of displaying a web resource to a user in a browser window of an electronic device. The method is executable at the electronic device. The method comprises: displaying the web resource substantially in an entirety of the browser window; responsive to receiving, via a user interface of the electronic device, an indication of a user desire to execute an action within the browser window, splitting the browser window into a first browser portion and a second browser portion, the first browser portion and the second portion occupying distinct portions of the browser window; displaying within the first browser portion a control panel, the control panel for enabling the user to execute the action within the browser window; displaying within the second browser portion a scaled down unobstructed representation of the web resource. 1. A method of displaying a web resource to a user in a browser window of an electronic device , the method executable at the electronic device , the method comprising:displaying the web resource substantially in an entirety of the browser window;responsive to receiving, via a user interface of the electronic device, an indication of a user desire to execute an action within the browser window, splitting the browser window into a first browser portion and a second browser portion, the first browser portion and the second portion occupying distinct portions of the browser window;displaying within the first browser portion an interactive control panel, the control panel for enabling the user to execute the action within the browser window; said interactive control panel having been generated by the browser application based at least in part on a browsing history;displaying within the second browser portion a scaled down unobstructed representation of the web resource.2. The method of claim 1 , further comprising displaying within the second browser portion claim 1 , in close proximity to the scaled down unobstructed ...

METHODS AND SYSTEMS FOR SELECTING TARGETED CONTENT BY MACHINE LEARNING ALGORITHM

Methods and systems for selecting targeted content by a machine learning algorithm (MLA) comprising: receiving and storing as a negative training example a first set of indications of blocked targeted content having been triggered by a user, each indication including a plurality of attributes of a blocked targeted content, receiving and storing as a positive training example a second set of indications of targeted content, each indication of the second set of indications comprising a plurality of attributes of a targeted content, training the MLA based on the positive training example and the negative training example to determine a type of to-be-selected targeted content, the type being one of a positive or a negative targeted content, responsive to receiving to-be-selected targeted content, determining based on the plurality of attributes of the targeted content the type of the targeted content and causing the electronic device to block negative type targeted content. 1. A computer-implemented method for selecting targeted content by a machine learning algorithm (MLA) , the method executable on a server , the server connectable to a plurality of electronic devices via a communication network , the method comprising:receiving, from the plurality of electronic devices, a first set of indications of blocked targeted content, each indication of the first set of indications having been triggered by a user of a electronic device of the plurality of electronic devices, each indication including a plurality of attributes of a blocked targeted content, the blocked targeted content having been displayed with a first resource on the electronic device;storing, by the server, the plurality of attributes of the blocked targeted content as a negative training example;receiving a second set of indications of targeted content, each indication of the second set of indications comprising a plurality of attributes of a targeted content, the targeted content having been displayed with ...

COMPOSITION AND METHOD FOR POLISHING SILICON CARBIDE

The invention provides a chemical-mechanical polishing composition comprising (a) silica particles, (b) a polymer comprising sulfonic acid monomeric units, (c) optionally, a buffering agent, and (d) water, wherein the polishing composition has a pH of about 2 to about 5. The invention further provides a method of chemically-mechanically polishing a substrate with the inventive chemical-mechanical polishing composition. Typically, the substrate comprises silicon carbide and silicon nitride. 2. The polishing composition of claim 1 , wherein the silica particles have an average particle size of about 40 nm to about 60 nm.3. The polishing composition of claim 1 , wherein the silica particles are substantially spherical.4. The polishing composition of claim 1 , wherein the polymer comprising sulfonic acid monomeric units has an average molecular weight of about 75 claim 1 ,000 g/mole to about 200 claim 1 ,000 g/mole.5. The polishing composition of claim 1 , wherein the polymer comprising sulfonic acid monomeric units is selected from polystyrenesulfonic acid claim 1 , poly(2-acrylamido-2-methyl-1-propanesulfonic acid) claim 1 , and poly(styrenesulfonic acid-co-maleic acid).6. The polishing composition of claim 1 , wherein the buffering agent is selected from formic acid claim 1 , malonic acid claim 1 , acetic acid claim 1 , oxalic acid claim 1 , citric acid claim 1 , and phosphoric acid.7. The polishing composition of claim 1 , wherein the polishing composition further comprises an oxidizing agent.8. The polishing composition of claim 7 , wherein the oxidizing agent is hydrogen peroxide.9. The polishing composition of claim 1 , wherein the polishing composition does not contain a piperazine compound claim 1 , a 4-morpholine compound claim 1 , an amino sulfonic acid compound claim 1 , a substituted amine compound claim 1 , a tertiary amine compound claim 1 , or a bis-amine compound claim 1 , or salts thereof. Compositions and methods for planarizing or polishing the ...

CMP COMPOSITION INCLUDING A NOVEL ABRASIVE

A chemical mechanical polishing composition includes a liquid carrier and colloidal silica particles dispersed in the liquid carrier. The colloidal silica particles have a positive charge of at least 10 mV in the liquid carrier and may be characterized as having: (i) a number average aspect ratio of greater than about 1.25 and (ii) a normalized particle size span by weight of greater than about 0.42. The polishing composition may further optionally include an iron-containing accelerator and a tungsten etch inhibitor, for example, when the polishing composition is a tungsten CMP composition. 1. A chemical mechanical polishing composition comprising:a liquid carrier;colloidal silica particles dispersed in the liquid carrier, the colloidal silica particles having a positive charge of at least 10 mV in the liquid carrier;an iron-containing accelerator;a metal etch inhibitor; andwherein the colloidal silica particles have (i) a number average aspect ratio of greater than about 1.25 and (ii) a normalized particle size span by weight of greater than about 0.42.2. The composition of claim 1 , wherein the colloidal silica particles have a number average aspect ratio of greater than about 1.35.3. The composition of claim 1 , wherein the colloidal silica particles have a normalized particle size span by weight of greater than about 0.6.4. The composition of claim 1 , wherein the colloidal silica particles have (i) a number average aspect ratio of greater than about 1.35 and a normalized particle size span by weight of greater than about 0.6.5. The composition of claim 1 , wherein the colloidal silica particles have a particle size distribution by number in which D50 is in a range from about 20 nm to about 60 nm.6. The composition of claim 1 , wherein the colloidal silica particles have a particle size distribution by weight in which D50 is in a range from about 60 nm to about 140 nm.7. The composition of claim 1 , wherein:the colloidal silica particles comprise a blend of ...

TRISPECIFIC ANTIBODIES AGAINST IL-17A, IL-17F AND OTHER PRO-INFLAMMATORY MOLECULE

The present invention relates to the field of biotechnology and provides monoclonal tri-specific binding molecules that specifically bind to human IL-17A, human IL-17F, and a human pro-inflammatory molecule (in particular, TNFα) with high affinity. The invention also relates to DNA constructs encoding said binding molecules, related expression vectors and methods of production, and methods of treatment using said binding molecules. 1. A tri-specific binding molecule comprising a first binding domain that binds to human IL-17A and human IL-17-F and a second binding domain that binds to a human pro-inflammatory molecule.2. The binding molecule according to claim 1 , wherein said binding molecule is an antibody or an antigen-binding fragment thereof.3. The binding molecule according to claim 1 , wherein said first binding domain comprises the amino acid sequence SEQ ID NO: 3.4. The binding molecule according to claim 1 , wherein said first binding domain comprises amino acid sequences corresponding to SEQ ID NOs: 1-3.5. The binding molecule according to claim 1 , wherein said first binding domain competes for binding with or binds to the same epitope as a binding domain comprising the amino acid sequence of SEQ ID NO: 4.6. The binding molecule according to claim 1 , wherein said first binding domain is at least 90% identical to SEQ ID NO: 4.7. The binding molecule according to claim 1 , wherein said first binding domain comprises the amino acid sequence of SEQ ID NO: 4.8. The binding molecule according to claim 1 , wherein said first binding domain is humanized.9. The binding molecule according to claim 1 , wherein said second binding domain binds to human TNFα.10. The binding molecule according to claim 9 , wherein said second binding domain competes for binding with or binds to the same epitope as a binding domain comprising one of:a) a heavy chain comprising amino acid sequences corresponding to SEQ ID NOs: 10-12 and a light chain comprising amino acid sequences ...

METHOD AND SYSTEM FOR NAVIGATING TO A SUB-RESOURCE OF AN INTERNET RESOURCE

The present relates to a method and system for navigating to a sub-resource of an Internet resource. The method and system comprises receiving information regarding a particularly determined sub-resource of the Internet resource. The particularly determined sub-resource is defined independently of the publisher of the Internet resource. The method and system comprises displaying, contemporaneously with the display of the Internet resource, a user-selectable object. The user-selectable object has an associated indication of the sub-resource of the Internet resource. And the method and system comprises, upon selection of the user-selectable object, displaying the sub-resource. 1. A method of navigating to at least one sub-resource of an Internet resource , the method comprising:sending, from a client device to at least one server, instructions to furnish the client device with the Internet resource;sending, from the client device to the at least one server, instructions to furnish the client device with information regarding at least one particularly determined sub-resource of the Internet resource, the at least one particularly determined sub-resource being defined independently of the publisher of the Internet resource;receiving, from the at least one server on the client device, the Internet resource;receiving, from the at least one server on the client device, the information regarding the at least one particularly determined sub-resource of the Internet resource;displaying, on the client device, the Internet resource;displaying, on the client device contemporaneously with the display of the Internet resource, at least one user-selectable object, the user-selectable object having an associated indication of the at least one sub-resource of the Internet resource, the associated indication based, at least in part, on the information;upon a user of the client device selecting one of the at least one user-selectable object, sending, from the client device to the at ...

PROCESSING A REQUEST FOR A WEB RESOURCE

There is disclosed a method of processing a user request for an access to a web resource, the method executable at an electronic device. The method comprises receiving, by a browsing application of the electronic device, a user request for access to the web resource; obtaining, via a communication network, information about the web resource; in response to the information being representative of an error accessing the web resource, causing simultaneous display in the browsing application: (i) in a first portion of the browser, a first error resolution field provided by the network resource being accessed, and (ii) in a second portion of the browser, a second error resolution field provided by an entity other than the network resource being accessed. 1. A method of processing a user request for an access to a web resource , the method executable at an electronic device , the method comprising:receiving, by a browsing application of the electronic device, a user request for access to the web resource;obtaining, via a communication network, information about the web resource; (i) in a first portion of the browser, a first error resolution field provided by a network resource being accessed, and', "(ii) in a second portion of the browser, a second error resolution field provided by the browser application, the second error resolution field comprising data based on the user's past browsing experience stored on the electronic device."], 'in response to the information being representative of an error accessing the web resource, causing simultaneous display in the browsing application2. (canceled)3. The method of claim 1 , wherein the information about the web resource is embodied in an error message.4. The method of claim 3 , further comprising receiving claim 3 , via the communications network claim 3 , the error message.5. The method of claim 4 , wherein the error message further comprises information instrumental for generating the first error resolution field.6. The ...

ADDITIVE PARTICLES FOR IMPROVING OPTICAL PERFORMANCE OF AN ELECTROPHORETIC DISPLAY

The present invention is directed to an electrophoretic fluid which comprises additive particles. The concentration of the additive particles in the electrophoretic fluid does not exceed 25% by weight and the additive particles are not seen at the viewing side during operation of the display. The resulting fluid can improve optical performance of a display device, such as image stability and contrast ratio. The present invention is also directed to an electrophoretic display comprising the electrophoretic fluid. 1. An electrophoretic fluid comprising charged pigment particles and neutral buoyancy particles dispersed in a solvent or solvent mixture ,wherein the concentration of the neutral buoyancy particles in the electrophoretic fluid does not exceed 25% by weight,the neutral buoyancy particles are not seen at the viewing side during operation of the display, andthe neutral buoyancy particles are uncharged or have a charge which is less than 50% of the average charge carried by the charged pigment particles.2. The fluid of claim 1 , wherein the neutral buoyancy particles have the same color as one type of charged pigment particles.3. The fluid of claim 1 , wherein the neutral buoyancy particles have a color different from that of the charged pigment particles.4. The fluid of claim 1 , wherein the neutral buoyancy particles are formed from a material selected from the group consisting of polyacrylate claim 1 , polymethacrylate claim 1 , polystyrene claim 1 , polyaniline claim 1 , polypyrrole claim 1 , polyphenol and polysiloxane.6. The fluid of claim 1 , wherein the neutral buoyancy particles are formed from a material having a refractive index different from that of the solvent or solvent mixture.7. The fluid of claim 1 , wherein the concentration of the neutral buoyancy particles in the electrophoretic fluid does not exceed 15% by weight.8. The fluid of wherein the concentration of the neutral buoyancy particles in the electrophoretic fluid does not exceed 10% by ...

Composition and method for polishing silicon carbide

The invention provides a chemical-mechanical polishing composition comprising (a) silica particles, (b) a polymer comprising sulfonic acid monomeric units, (c) optionally, a buffering agent, and (d) water, wherein the polishing composition has a pH of about 2 to about 5. The invention further provides a method of chemically-mechanically polishing a substrate with the inventive chemical-mechanical polishing composition. Typically, the substrate comprises silicon carbide and silicon nitride.

Composition and method for copper barrier cmp

A chemical mechanical polishing composition for polishing a substrate having copper, barrier, and dielectric layers includes a water based liquid carrier, cationic silica abrasive particles dispersed in the liquid carrier, and a triazole compound, wherein the polishing composition has a pH of greater than about 6 and the cationic silica abrasive particles have a zeta potential of at least 10 mV. The triazole compound is not benzotriazole or a benzotriazole compound. A method for chemical mechanical polishing a substrate including copper, barrier, and dielectric layers includes contacting the substrate with the above described polishing composition, moving the polishing composition relative to the substrate, and abrading the substrate to remove a portion of the copper, barrier, and dielectric layers from the substrate and thereby polish the substrate.

Composition and method for cobalt cmp

A chemical mechanical polishing composition for polishing a substrate having a cobalt layer includes a water based liquid carrier, cationic silica abrasive particles dispersed in the liquid carrier, and a triazole compound, wherein the polishing composition has a pH of greater than about 6 and the cationic silica abrasive particles have a zeta potential of at least 10 mV. The triazole compound is not benzotriazole or a benzotriazole compound. A method for chemical mechanical polishing a substrate including a cobalt layer includes contacting the substrate with the above described polishing composition, moving the polishing composition relative to the substrate, and abrading the substrate to remove a portion of the cobalt layer from the substrate and thereby polish the substrate.

Composition for tungsten CMP

A chemical mechanical polishing composition includes a water based liquid carrier, cationic abrasive particles dispersed in the liquid carrier, a first amino acid compound having an isoelectric point of less than 7 and a second amino acid compound having an isoelectric point of greater than 7. The pH of the composition is in a range from about 1 to about 5. A method for chemical mechanical polishing a substrate including a tungsten layer includes contacting the substrate with the above described polishing composition, moving the polishing composition relative to the substrate, and abrading the substrate to remove a portion of the tungsten from the substrate and thereby polish the substrate.

Composition and method for copper barrier CMP

A chemical mechanical polishing composition for polishing a substrate having copper, barrier, and dielectric layers includes a water based liquid carrier, cationic silica abrasive particles dispersed in the liquid carrier, and a triazole compound, wherein the polishing composition has a pH of greater than about 6 and the cationic silica abrasive particles have a zeta potential of at least 10 mV. The triazole compound is not benzotriazole or a benzotriazole compound. A method for chemical mechanical polishing a substrate including copper, barrier, and dielectric layers includes contacting the substrate with the above described polishing composition, moving the polishing composition relative to the substrate, and abrading the substrate to remove a portion of the copper, barrier, and dielectric layers from the substrate and thereby polish the substrate.

Composition and method for copper barrier cmp

Cleaning composition and method for cleaning semiconductor wafers after cmp

The invention provides a composition for cleaning contaminants from semiconductor wafers following chemical-mechanical polishing. The cleaning composition contains one or more quaternary ammonium hydroxides, one or more organic amines, one or more metal inhibitors, and water. The invention also provides methods for using the cleaning composition.

Composition and method for metal CMP

A chemical mechanical polishing composition for polishing a substrate includes a liquid carrier and cationic metal oxide abrasive particles dispersed in the liquid carrier. The cationic metal oxide abrasive particles have a surface modified with at least one compound consisting of a silyl group having at least one quaternary ammonium group. A method for chemical mechanical polishing a substrate including a metal layer includes contacting the substrate with the above described polishing composition, moving the polishing composition relative to the substrate, and abrading the substrate to remove a portion of the metal layer from the substrate and thereby polish the substrate.

Cleaning composition and method for cleaning semiconductor wafers after CMP

The invention provides a composition for cleaning contaminants from semiconductor wafers following chemical-mechanical polishing. The cleaning composition contains one or more quaternary ammonium hydroxides, one or more organic amines, one or more metal inhibitors, and water. The invention also provides methods for using the cleaning composition.

Derivatized polyamino acids

A composition comprises, consists of, or consists essentially of a polymer including a derivatized amino acid monomer unit. A chemical mechanical polishing composition includes a water based liquid carrier, abrasive particles dispersed in the liquid carrier, and a cationic polymer having a derivatized amino acid monomer unit. A method of chemical mechanical polishing includes utilizing the chemical mechanical polishing composition to remove at least a portion of a metal or dielectric layer from a substrate and thereby polish the substrate.

Derivatized polyamino acids

A composition comprises, consists of, or consists essentially of a polymer including a derivatized amino acid monomer unit. A chemical mechanical polishing composition includes a water based liquid carrier, abrasive particles dispersed in the liquid carrier, and a cationic polymer having a derivatized amino acid monomer unit. A method of chemical mechanical polishing includes utilizing the chemical mechanical polishing composition to remove at least a portion of a metal or dielectric layer from a substrate and thereby polish the substrate.

Composition for tungsten cmp

Cleaning composition following cmp and methods related thereto

Cleaning composition and method for cleaning semiconductor wafers after cmp

AQUEOUS PHARMACEUTICAL COMPOSITION OF AN ANTI-IL17A ANTIBODY AND USE THEREOF

The present disclosure relates to aqueous compositions for anti-IL17a antibodies, and more particularly to aqueous compositions for anti-IL17a antibodies with a Vvariable domain and a Vvariable domain, and can be used as a medicinal agent for treating IL-17A-mediated diseases. 1. An aqueous pharmaceutical composition suitable for parenteral administration to a subject for inhibiting IL17a protein activity comprising:a pharmaceutically effective amount of an anti-IL17a antibody comprising a VHH-derivative domain and a variable VL domain;a histidine-based buffering agent; andan effective amount of a sugar-based alcohol as an osmotic agent.2. The aqueous pharmaceutical composition as defined in claim 1 , wherein said VHH-derivative domain of said anti-IL17a antibody comprises 3 hypervariable regions HCDR1 claim 1 , HCDR2 and HCDR3 claim 1 , wherein:HCDR1 comprises the amino acid sequence of SEQ ID NO: 1;HCDR2 comprises the amino acid sequence of SEQ ID NO: 2;HCDR3 comprises the amino acid sequence of SEQ ID NO: 3; andwherein the variable VL domain of said anti-IL17a antibody comprises the amino acid sequence of SEQ ID NO: 4.3. The aqueous pharmaceutical composition as defined in claim 1 , wherein said anti-IL17a antibody is Netakimab.4. The aqueous pharmaceutical composition as defined in claim 1 , wherein said Netakimab is of an amount of 5 mg/mL to 150 mg/mL.5. The aqueous pharmaceutical composition as defined in claim 1 , wherein said Netakimab is of an amount of 10 mg/mL to 100 mg/mL.6. The aqueous pharmaceutical composition as defined in claim 1 , wherein said Netakimab is of an amount of 40 mg/mL claim 1 , 60 mg/mL or 70 mg/mL.78-. (canceled)9. The aqueous pharmaceutical composition as defined in claim 1 , wherein said sugar-based alcohol is Mannitol.10. The aqueous pharmaceutical composition as defined claim 9 , wherein said Mannitol is in an amount of 25-60 mg/mL.11. The aqueous pharmaceutical composition as defined in claim 1 , wherein a suitable amount of ...

Aqueous pharmaceutical composition of an anti-il17a antibody and use thereof

The present disclosure relates to aqueous compositions for anti-IL17a antibodies, and more particularly to aqueous compositions for anti-IL17a antibodies with a V HH variable domain and a V L variable domain, and can be used as a medicinal agent for treating IL-17А-mediated diseases.

Trispecific antibodies against IL-17A, IL-17F and another proinflammatory molecule

The present invention relates to the field of biotechnology and proposes monoclonal trispecific binding molecules which specifically bind to human IL-17A, human IL-17F and a human proinflammatory molecule (in particular, TNF-alpha) with a high degree of affinity. The invention also relates to DNA constructs which code for such binding molecules, corresponding expression vectors and production methods, and also treatment methods using said binding molecules.

Antibody Or An Antigen-Binding Fragment Thereof Capable Of Binding To A Human Receptor Of Interleukin-6.

The invention relates to medicine. The problem addressed by the present invention consists in creating alternative antibodies or fragments thereof which are capable of specifically binding to a human receptor of interleukin-6 and which would be usefiil as drugs for treating or diagnosing diseases, or for relieving symptoms, mediated by interleukin-6.

Monoclonal antibodies that bind specifically to human trbv9

The invention relates to a monoclonal humanized antibody or an antigen-binding fragment thereof which bind specifically to the TRBV9 family of human ?-cell receptors. The invention also relates to a nucleic acid which codes for said antibody or for an antigen-binding fragment thereof, an expression vector, a method for producing the antibody, and the use of said antibody for treating diseases or disorders associated with said family of human T-cell receptors. The invention is directed towards producing antibodies which can be used, in particular, for treating ankylosing spondylitis (AS or Bekhterev's disease), coeliac disease and blood cancers, the pathogenesis of which involves T-cell receptors of the TRBV9 family.

Composition and method for cobalt cmp

A chemical mechanical polishing composition for polishing a substrate having a cobalt layer includes a water based liquid carrier, cationic silica abrasive particles dispersed in the liquid carrier, and a triazole compound, wherein the polishing composition has a pH of greater than about 6 and the cationic silica abrasive particles have a zeta potential of at least 10 mV. The triazole compound is not benzotriazole or a benzotriazole compound. A method for chemical mechanical polishing a substrate including a cobalt layer includes contacting the substrate with the above described polishing composition, moving the polishing composition relative to the substrate, and abrading the substrate to remove a portion of the cobalt layer from the substrate and thereby polish the substrate.

Monoclonal antibody that binds specifically to gitr

The present invention relates to biotechnology, in particular to antibodies or antigen-binding fragments thereof, and to use thereof. More particularly, the present invention relates to monoclonal antibodies that specifically bind to GITR. The invention also relates to a nucleic acid encoding said antibody or antigen-binding fragment thereof, an expression vector, a method for preparing said antibody, and use of said antibody in treatment of diseases or disorders associated with GITR.

MONOCLONAL ANTIBODIES AGAINST HUMAN TRBV9 BETA CHAIN REGION

anticorpos monoclonais contra a região de cadeia beta do trbv9 humano. a invenção refere-se a um anticorpo monoclonal humanizado ou fragmento de ligação de antígeno do mesmo que se liga especificamente à família trbv9 do receptor de células t humanas. a invenção também se refere a um ácido nucleico que codifica, o referido anticorpo ou fragmento de ligação de antígeno do mesmo, um vetor de expressão, um método para preparar o referido anticorpo e o uso do referido anticorpo no tratamento de doenças ou distúrbios associados à família de receptores de células t humanas. a invenção é direcionada à geração de anticorpos que podem ser usados para tratar, em particular as, doença celíaca e doenças malignas do sangue, cuja patogênese envolve os tcrs da família trbv9.

MONOCLONAL ANTIBODY SPECIFICALLY JOINING GITR

La presente se refiere a la biotecnología en particular a los anticuerpos o fragmentos de unión al antígeno de este, y a su uso. Más particularmente, la presente se refiere a anticuerpos monoclonales que se unen específicamente a GITR. La misma también se refiere a un ácido nucleico que codifica dicho anticuerpo o fragmento de unión al antígeno de este, un vector de expresión, un método para preparar dicho anticuerpo y el uso de dicho anticuerpo en el tratamiento de enfermedades o trastornos asociados con GITR. The present biotechnology relates in particular to antibodies or antigen-binding fragments thereof, and their use. More particularly, this relates to monoclonal antibodies that specifically bind to GITR. It also relates to a nucleic acid encoding said antibody or antigen-binding fragment thereof, an expression vector, a method for preparing said antibody and the use of said antibody in the treatment of diseases or disorders associated with GITR.

Nuclear reactor fuel assembly

The invention relates to nuclear-power engineering and, more particularly, to fuel assemblies of nuclear reactors with water under pressure.The object to be solved with the claimed invention is the fuel assemblies reliability enhancement and the reducing of their manufacturing costThe technical result of the invention is the creation of a fuel assembly structure with a lower grid, having a rigid connection with the FA bottom nozzle fins, which allows to reduce the lower grid thickness and to reduce the hydraulic resistance at the lower, non-heated section of the fuel assembly.The technical result is provided by that in a fuel assembly, comprising the fuel elements bundle, spacer grids, tubular channels, the lower grid and the bottom nozzle with fins, according to the invention, the lower grid is provided with a pin, and the bottom nozzle fins are provided with a bushing, wherein the central pin and the bushing are joined fixedly. 1 ill.

Cleaning composition following CMP and methods related thereto

The invention provides a composition for cleaning contaminants from semiconductor wafers following chemical-mechanical polishing. The cleaning composition contains a bulky protecting ligand, an organic amine, an organic inhibitor, and water. The invention also provides methods for using the cleaning composition.

High affinity and aggregatively stable antibodies on the basis of variable domains vl and a derivative vhh

What are proposed are: monoclonal antibodies of the type IgG comprising variable domains in the form of a combination of a derivative VHH with a variable domain of a light chain VL. The antibodies mentioned may comprise amino acid substitutions in positions 44 and/or 45 (according to the Kabat numbering scheme) or combinations thereof. The antibodies described have increased affinity and improved aggregation stability.

Anti-PD-1 antibodies, method for producing same and method for using same

The present invention relates to biotechnology and comprises isolated monoclonal antibodies, in particular human monoclonal antibodies, which specifically bind to PD-1 with high affinity. The antibodies according to the invention may be chimeric, humanized or human antibodies, or antigen-binding fragments thereof, and may be used as a medicinal agent in oncology and immuno-oncology, for treating diseases associated with various cell proliferation or development disorders. The invention also relates to methods for producing said antibodies and a method for treating human diseases using said antibodies.

Cleaning composition following CMP and methods related thereto

Monoclonal antibody that binds specifically to gitr

The present invention relates to the field of biotechnology, and particularly to antibodies or their antigen-binding fragments, and to the use thereof. More particularly, the present invention relates to monoclonal antibodies that bind specifically to GITR. The invention also relates to a nucleic acid that codes for said antibody or for an antigen-binding fragment thereof, an expression vector, a method for producing the antibody, and the use of said antibody for treating diseases or disorders associated with GITR.

Monoclonal Antibodies That Bind Specifically to the Trbv-9 Family Beta Region of the Human T-Cell Receptor, and Methods for Their Use

La invención se refiere a un anticuerpo humanizado monoclonal o fragmento de unión al antígeno del mismo que se une específicamente a la familia TRBV9 del receptor de células T humanas. La invención también se refiere a un ácido nucleico que codifica dicho anticuerpo o fragmento de unión al antígeno del mismo, un vector de expresión, un método para preparar dicho anticuerpo, y el uso de dicho anticuerpo en el tratamiento de las enfermedades o trastornos asociados con la familia de receptores de células T humanas. La invención se dirige a la generación de anticuerpos que se pueden usar para tratar, en particular AS, enfermedad celíaca y enfermedades sanguíneas malignas, cuya patogénesis involucra los TCR de la familia TRBV9. The invention relates to a humanized monoclonal antibody or antigen-binding fragment thereof that specifically binds to the human T-cell receptor family TRBV9. The invention also relates to a nucleic acid encoding said antibody or antigen-binding fragment thereof, an expression vector, a method for preparing said antibody, and the use of said antibody in the treatment of diseases or disorders associated with the human T cell receptor family. The invention is directed to the generation of antibodies that can be used to treat, in particular AS, celiac disease and malignant blood diseases, the pathogenesis of which involves the TCRs of the TRBV9 family.

A ceramic composite material with functionally graded properties

Leiutis käsitleb komposiitkeraamikat ja eelkõige funktsionaalselt gradeeritud elektrit ja soojust juhtivat keraamikat, mis sisaldab keraamilisi metallioksiidkiudusid, mis on kaetud mitme kihi grafeeniga. Komposiit on liigendatud nii mehaaniliste omaduste, nimelt murdetugevuse ja kõvaduse järgi, kui ka elektrijuhtivuse ja soojusjuhtivuse järgi. Struktuurselt on ka tera suurus materjali eri kihtides olulisel määral ja ettekavandatavalt gradeeritav.

NUCLEASA PACAS9

La presente invencion se refiere al campo de la biotecnologia, la biologia molecular y la medicina; en particular, a la enzima nucleasa y su uso. Mas especificamente, la presente invencion se refiere a la enzima nucleasa PaCas9. La invencion tambien se refiere a un acido nucleico que codifica dicha nucleasa, un constructo genetico, un vector de expresion, un vector de administracion que comprende dicho acido nucleico, un liposoma que comprende dicha nucleasa o acido nucleico que codifica dicha nucleasa, un metodo para producir una nucleasa, metodos para la administracion, y una celula hospedadora que comprende un acido nucleico que codifica dicha nucleasa The present invention relates to the field of biotechnology, molecular biology and medicine; in particular, to the nuclease enzyme and its use. More specifically, the present invention relates to the nuclease enzyme PaCas9. The invention also relates to a nucleic acid encoding said nuclease, a genetic construct, an expression vector, a delivery vector comprising said nucleic acid, a liposome comprising said nuclease or nucleic acid encoding said nuclease, a method for producing a nuclease, methods for administration, and a host cell comprising a nucleic acid encoding said nuclease

Monoclonal antibodies against the beta chain region of human TRBV9

The invention relates to a monoclonal humanized antibody or an antigen-binding fragment thereof which bind specifically to the TRBV9 family of human Т-cell receptors. The invention also relates to a nucleic acid which codes for said antibody or for an antigen-binding fragment thereof, an expression vector, a method for producing the antibody, and the use of said antibody for treating diseases or disorders associated with said family of human T-cell receptors. The invention is directed towards producing antibodies which can be used, in particular, for treating ankylosing spondylitis (AS or Bekhterev's disease), coeliac disease and blood cancers, the pathogenesis of which involves T-cell receptors of the TRBV9 family.

Aqueous pharmaceutical composition of an anti-il17a antibody and use thereof

The present disclosure relates to aqueous compositions for anti-IL17a antibodies, and more particularly to aqueous compositions for anti-IL17a antibodies with a VHH variable domain and a VL variable domain, and can be used as a medicinal agent for treating IL-17?-mediated diseases.

Monoclonal antibodies against the beta chain region of human trbv9

Method and systems for navigating to a sub-resource of an internet resource

The present relates to a method and system for navigating to a sub-resource of an Internet resource. The method and system comprises receiving information regarding a particularly determined sub-resource of the Internet resource. The particularly determined sub-resource is defined independently of the publisher of the Internet resource. The method and system comprises displaying, contemporaneously with the display of the Internet resource, a user-selectable object. The user-selectable object has an associated indication of the sub-resource of the Internet resource. And the method and system comprises, upon selection of the user-selectable object, displaying the sub-resource.

Anti-pd-1 antibodies, method of production and use

La présente invention concerne la biotechnologie et se présente comme des anticorps monoclonaux extraits, notamment des anticorps monoclonaux humains qui se lient spécifiquement à pd-1 avec une affinité élevée. Les anticorps de l’invention peuvent être chimériques, humanisés ou humains ou leurs fragments de liaison d’antigènes et peuvent s'utiliser en tant que médicament en oncologie ou oncologie immunitaire pour la thérapie des maladies liées à diverses perturbations de la prolifération et de développement des cellules. L'invention concerne aussi des procédés de production de ces anticorps et une méthode de traitement des maladies humaines au moyen des anticorps présents. The present invention relates to biotechnology and is presented as extracted monoclonal antibodies, including human monoclonal antibodies which specifically bind to pd-1 with high affinity. The antibodies of the invention can be chimeric, humanized or human or their antigen binding fragments and can be used as a medicament in oncology or immune oncology for the therapy of diseases related to various disturbances of proliferation and development. cells. The invention also relates to methods of producing such antibodies and to a method of treating human diseases using the antibodies present.

Anti-pd-1 antibodies, a method of production and a method of use thereof

The present invention relates to biotechnology and comprises isolated monoclonal antibodies, in particular human monoclonal antibodies, which specifically bind to PD-1 with high affinity. The antibodies according to the invention may be chimeric, humanized or human antibodies, or antigen-binding fragments thereof, and may be used as a medicinal agent in oncology and immuno-oncology, for treating diseases related to various disorders of cell proliferation and development. The invention also relates to methods for producing the indicated antibodies, and to a method for treating human diseases using said antibodies.

MONOCLONAL ANTIBODY SPECIFICALLY BINDING TO CD20 ANTIGEN

La presente se refiere a la biotecnología y proporciona un anticuerpo monoclonal que se une específicamente al antígeno CD20. La presente también se refiere a ADN que codifica dicho anticuerpo, los correspondientes vectores de expresión y métodos para su producción, al igual que métodos de tratamiento para emplear dicho anticuerpo. Reivindicación 1: Un anticuerpo monoclonal o fragmento de unión al antígeno de este que se une específicamente a CD20 que comprende: a) un dominio variable de la cadena pesada que comprende una secuencia de aminoácidos que se muestra en la SEQ ID Nº 2 o SEQ ID Nº 6; b) un dominio variable de la cadena ligera que comprende una secuencia de aminoácidos que se muestra en la SEQ ID Nº 4 o SEQ ID Nº 8. Reivindicación 10: Un ácido nucleico que codifica un anticuerpo o fragmento de unión al antígeno de este según cualquiera de las reivindicaciones 1 - 9. Reivindicación 12: Un vector de expresión que comprende un ácido nucleico según cualquiera de las reivindicaciones 10 - 11. Reivindicación 13: Un método para la producción de una célula hospedante para producir un anticuerpo o fragmento de unión al antígeno de este según cualquiera de las reivindicaciones 1 - 9 que comprende la transformación de una célula con un vector según la reivindicación 12. Reivindicación 14: Una célula hospedante para producir un anticuerpo o fragmento de unión al antígeno de este según cualquiera de las reivindicaciones 1 - 9, que comprende un ácido nucleico según cualquiera de las reivindicaciones 10 - 11. Reivindicación 15: Un método para la producción de un anticuerpo o fragmento de unión al antígeno de este según cualquiera de las reivindicaciones 1 - 9, que comprende cultivar una célula hospedante según la reivindicación 14 en un medio de cultivo en condiciones suficientes para producir dicho anticuerpo o fragmento de unión al antígeno de este, si es necesario, seguido del aislamiento y la purificación del anticuerpo producido o de un fragmento de unión al antígeno ...

Method and system for navigating to a sub-resource of an internet resource

The present relates to a method and system for navigating to a sub-resource of an Internet resource. The method and system comprises receiving information regarding a particularly determined sub-resource of the Internet resource. The particularly determined sub-resource is defined independently of the publisher of the Internet resource. The method and system comprises displaying, contemporaneously with the display of the Internet resource, a user-selectable object. The user-selectable object has an associated indication of the sub-resource of the Internet resource. And the method and system comprises, upon selection of the user-selectable object, displaying the sub-resource.

Monoclonal antibodies that specifically bind to the beta region of the trbv-9 family of the human T cell receptor, and methods for their use.

La invención se refiere a un anticuerpo humanizado monoclonal o fragmento de unión al antígeno del mismo que se une específicamente a la familia TRBV9 del receptor de células T humanas. La invención también se refiere a un ácido nucleico que codifica dicho anticuerpo o fragmento de unión al antígeno del mismo, un vector de expresión, un método para preparar dicho anticuerpo, y el uso de dicho anticuerpo en el tratamiento de las enfermedades o trastornos asociados con la familia de receptores de células T humanas. La invención se dirige a la generación de anticuerpos que se pueden usar para tratar, en particular AS, enfermedad celíaca y enfermedades sanguíneas malignas, cuya patogénesis involucra los TCR de la familia TRBV9. The invention relates to a humanized monoclonal antibody or antigen-binding fragment thereof that specifically binds to the human T-cell receptor family TRBV9. The invention also relates to a nucleic acid encoding said antibody or antigen-binding fragment thereof, an expression vector, a method for preparing said antibody, and the use of said antibody in the treatment of diseases or disorders associated with the human T cell receptor family. The invention is directed to the generation of antibodies that can be used to treat, in particular AS, celiac disease and malignant blood diseases, the pathogenesis of which involves the TCRs of the TRBV9 family.

Bottom nozzle of nuclear reactor fuel assembly

The nuclear reactor fuel assembly bottom nozzle comprises a support element, a diffuser, a hexagonal frame, connected coaxially to each other, with variable height fins fixed in non-adjacent corners of the hexagonal frame with a displacement from the plane of symmetry of the corners so that the end of one rib is mated with the side surface of the other rib. The profile of the fins is made with a ledge on the side surface of the fins and a thinning of the upper edge of the fins, the ledge serves to install the rim of the anti-debris filter, and the thinning serves to abut against the support grid of the fuel element bundle.The thinning of the fins can be made in the form of teeth with flat tops.The technical result is an increased reliability of the bottom nozzle and of the fuel assembly as a whole due to reduced hydraulic resistance of the bottom nozzle and reduced vibration loading of fuel elements.

Trispecific antibodies against il-17a, il-17f and another proinflammatory molecule

Aqueous pharmaceutical composition of an anti-il17a antibody and use thereof

Esta divulgación se refiere a composiciones acuosas de anticuerpos anti-IL17a y, particularmente, a composiciones acuosas de anticuerpos anti-IL17a con un dominio variable VHH y un dominio variable VL. Estas composiciones pueden ser utilizadas como agentes medicinales para tratar enfermedades mediadas por IL-17¿.

Silicon carbonitride polishing composition and method

A chemical mechanical polishing composition for polishing a substrate including a silicon carbonitride layer, the composition comprising, consisting essentially of, or consisting of a water based liquid carrier, anionic colloidal silica particles dispersed in the liquid carrier, a topography control agent, and having a pH in a range from about 2 to about 7.

Monoclonal antibodies against the beta chain region of human trbv9

The invention relates to a monoclonal humanized antibody or an antigen-binding fragment thereof which bind specifically to the TRBV9 family of human ?-cell receptors. The invention also relates to a nucleic acid which codes for said antibody or for an antigen-binding fragment thereof, an expression vector, a method for producing the antibody, and the use of said antibody for treating diseases or disorders associated with said family of human T-cell receptors. The invention is directed towards producing antibodies which can be used, in particular, for treating ankylosing spondylitis (AS or Bekhterevand#39;s disease), coeliac disease and blood cancers, the pathogenesis of which involves T-cell receptors of the TRBV9 family.

Nuclear reactor's fuel assembly

A nuclear reactor fuel assembly with a cross section in the shape of a regular hexagon comprises a top nozzle and a bottom nozzle, guide channels, fuel rods arranged in the nodes of a triangular mesh, and a grid consisting of non-detachably interconnected cells in the form of a polygonal tube, the longitudinal axis of which coincides with the longitudinal axis of a fuel rod. Six nonadjacent sides of a cell are slanted as a result of a variation in the width of the side along the axis of the cell. Between the slanted sides are sides which are parallel to the axis of the fuel assembly and which connect the cells to one another. The cells are arranged in the grid in rows that are parallel to one of the main diagonals of a regular hexagon. One pair of opposite slanted sides has a smaller edge width at the top nozzle end than at the bottom nozzle end. The axis of symmetry of a cell, which intersects these sides, forms an angle of 30 degrees with the aforementioned diagonal. The remaining slanted sides have a greater edge width at the top nozzle end than at the bottom nozzle end. The cells of each row are oriented identically, and the axes of symmetry of the cells in adjacent rows form an angle of 60 degrees. The width of the slanted sides of the cells varies along the axis of a cell in such a way that the cross sectional area of the cell is constant along the axis. The invention allows a reactor facility to be used in an elevated operating mode within

Trispecific antibodies against il-17a, il-17f and other proinflammatory molecule

The present invention relates to the field of biotechnology and proposes monoclonal trispecific binding molecules which specifically bind to human IL-17A, human IL-17F and a human proinflammatory molecule (in particular, TNF-alpha) with a high degree of affinity. The invention also relates to DNA constructs which code for such binding molecules, corresponding expression vectors and production methods, and also treatment methods using said binding molecules.

Monoclonal antibodies against the beta chain region of human trbv9

The invention relates to a monoclonal humanized antibody or antigen-binding fragment thereof that specifically bind to the TRBV9 family of the human T cell receptor. The invention also relates to a nucleic acid encoding said antibody or antigen-binding fragment thereof, an expression vector, a method for preparing said antibody, and use of said antibody in treatment of diseases or disorders associated with the human T cell receptor family. The invention is directed to generation of antibodies that can be used for treating, in particular AS, celiac disease and malignant blood diseases, the pathogenesis of which involves the TRBV9 family TCRs.

Nuclear reactor fuel assembly

Nuclear reactor fuel assembly

Composition and method for metal cmp

Aqueous pharmaceutical composition of an anti-il17a antibody and use thereof

Composition and method for silicon nitride cmp

CMP composition including a novel abrasive

A chemical mechanical polishing composition includes a liquid carrier and colloidal silica particles dispersed in the liquid carrier. The colloidal silica particles have a positive charge of at least 10 mV in the liquid carrier and may be characterized as having: (i) a number average aspect ratio of greater than about 1.25 and (ii) a normalized particle size span by weight of greater than about 0.42. The polishing composition may further optionally include an iron-containing accelerator and a tungsten etch inhibitor, for example, when the polishing composition is a tungsten CMP composition.

Composition for tungsten cmp

Composition and method for metal cmp

Derivatized polyamino acids

Bottom nozzle of nuclear reactor fuel assembly

Electrophoretic display fluid

The invention is directed to an electrophoretic fluid which can improve display performance such as switching speed, vertical bistability and the ghosting effect, and also reduce display defects. The electrophoretic fluid comprises charged pigment particles dispersed in a mixture of isoparaffins.

電泳顯示流體

本發明有關一種電泳流體，其可改良顯示效能，諸如切換速度、垂直雙穩定性及重像效應，且亦減少顯示缺陷。該電泳流體包含分散於異烷烴混合物中之帶電顏料粒子。

Composition and method for polishing boron doped polysilicon

The invention provides a method of chemically mechanically polishing a substrate, especially a substrate comprising boron doped polysilicon, comprising contacting the substrate with a chemical-mechanical polishing composition comprising an abrasive selected from α-alumina, silica, and a combination thereof, ferric ion, an organic acid, or a combination thereof, and water. The invention also provides a chemical-mechanical polishing composition comprising α-alumina, a nitrogen containing compound selected from a zwitterionic homopolymer at, a monomeric ammonium salt, and a combination thereof, an organic acid, and water. The invention further provides a chemical-mechanical polishing composition comprising silica, an organic acid, ferric ion, and water.

Silicon carbonitride polishing composition and method

A chemical mechanical polishing composition for polishing a substrate including a silicon carbonitride layer, the composition comprising, consisting essentially of, or consisting of a water based liquid carrier, anionic colloidal silica particles dispersed in the liquid carrier, a topography control agent, and having a pH in a range from about 2 to about 7.