12-12-2013 дата публикации
Номер: US20130331377A1
The present invention provides a diaminopyrimidine derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, a pharmaceutical composition comprising the same, and a use thereof. The diaminopyrimidine derivative or its pharmaceutically acceptable salt functions as a 5-HTreceptor agonist, and therefore can be usefully applied for preventing or treating dysfunction in gastrointestinal motility, one of the gastrointestinal diseases, such as gastroesophageal reflux disease (GERD), constipation, irritable bowel syndrome (IBS), dyspepsia, post-operative ileus, delayed gastric emptying, gastroparesis, intestinal pseudo-obstruction, drug-induced delayed transit, or diabetic gastric atony. 2. The method of claim 1 , wherein{'sub': 1', '1-5', '1-5', '2-6', '2-6', '1-5', '1-5', '1-5', '1-5', '1-5', '1-5', '1-5', '1-5, 'Ris a phenyl group substituted with one or more substituents selected from the group consisting of hydroxy, amino, halogen, cyano, nitro, hydroxycarbonyl, Calkyl (where the Calkyl is optionally substituted with halogen or amino), Calkenyl, Calkynyl, Calkoxy (where the Calkoxy is optionally substituted with halogen), Calkylthio, mono- or di-Calkylamino, Calkylsulfonylamino, Calkylcarbonylamino, Calkoxycarbonyl, aminosulfonyl, aminocarbonyl, Calkylaminocarbonyl, and benzyloxycarbonylamino; or'}{'sub': 1-5', '1-5', '1-5', '1-5', '1-5', '1-5, 'a heteroaryl group selected from the group consisting of pyridinyl, pyrimidinyl, pyrazinyl, imidazolyl, pyrazolyl, triazolyl, oxazolyl, thiazolyl, furanyl, pyrrolyl, thiophenyl, naphthyl, indanyl, quinolinyl, quinolinonyl, chromenonyl, dihydroindolonyl, isoindoline-1,3-dionyl, dihydrobenzimidazolonyl, benzoxazolonyl, benzofuranyl, benzothiophenyl, benzo[d][1,3]dioxolyl, dihydrobenzo[1,4]dioxinyl, indolyl, indolinyl, benzimidazolyl, benzoxazolyl, benzothiazolyl, and indazolyl, wherein the heteroaryl group may be optionally substituted with one or more substituents selected from the group ...
Подробнее
