Portable storage container with cable management functionality and a method for managing cables of a portable storage container

There is provided a portable storage container with cable management functionality, including: a case constructed from a rigid material with a first extent and a second extent in an adjacent relationship therewith, the first and second extent each defining an interior space for the placement of at least one speaker driver in at least one extent, the at least one speaker driver being connected through a cable with a connector, rear portions of the first and second extent being pivotally coupled together, at least one extent having an extended rim along an edge of the interior space, the rim defining a groove along the edge of the interior space, the groove being used for aligning the cable, and a fastener for fastening edges of the first and second extent. The fastener may feed the cable into the groove when fastening the edges of the first and second extent. A corresponding method for managing at least one cable in a portable storage container is also disclosed.

Bicyclic pyrimidine derivatives as calcium channel blockers

Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted T-type calcium channel activity are disclosed. Specifically, a series of compounds containing thienopyrimidine or oxoquinazoline derivatives are disclosed of the general formula (1) or formula (2) where X is a linker and Y is an aromatic moiety or N(R5)(R6).

N-piperidinyl acetamide derivatives as calcium channel blockers

Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted T-type calcium channel activity are disclosed. Specifically, a series of compounds containing N-piperidinyl acetamide derivatives as shown in formula (1).

Methods to reduce radio link control retransmission

Methods, systems, and devices for wireless communications are described. A receiving device may receive, at a first operational layer of the receiving device, one or more protocol data units (PDUs) within a set of PDUs. The receiving device may identify, at a second operational layer of the receiving device, a sequence gap associated with a missing PDU from the set of PDUs, the first operational layer being a lower operational layer of the receiving device than the second operational layer. The receiving device may determine, at the second operational layer, that a triggering condition associated with the missing PDU has occurred. The receiving device may provide, by the second operational layer and based at least in part on the triggering condition occurring, an indication to update a reception buffer of the first operational layer to a last received protocol data unit of the set of PDUs.

Systems and methods for wireless communication

Various aspects of the present disclosure generally relate to wireless communication. In some aspects, a method may include simulating a degradation of at least one of a first wireless communication link with a network or a different second wireless communication link with the network based on detecting that a first set of one or more packets, which were received via the first wireless communication link with the network and were added to a packet buffer, and a second set of one or more packets, which were received via the different second wireless communication link with the network and were added to the packet buffer, satisfy a threshold occupancy of the packet buffer. Numerous other aspects are provided.

N-piperidinyl acetamide derivatives as calcium channel blockers

Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted T-type calcium channel activity are disclosed. Specifically, a series of compounds containing N-piperidinyl acetamide derivatives as shown in formula (1).

4-(AMINOMETHYL)CYCLOHEXANAMINE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS

Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted T-type calcium channel activity are disclosed. Specifically, a series of compounds containing 4-(aminomethyl)cyclohexanamine derivatives as shown in formula (1).

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N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS

Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted T-type calcium channel activity are disclosed. Specifically, a series of compounds containing N-piperidinyl acetamide derivatives as shown in formula (1).

N-piperidinyl acetamide derivatives as calcium channel blockers

Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted T-type calcium channel activity are disclosed. Specifically, a series of compounds containing N-piperidinyl acetamide derivatives as shown in formula (1).

Flow Control Method and Apparatus

An apparatus and method for redirecting fluid flow in a plenum provides flow performance (quality), structural, and economic advantages by using an array of flat blades that is mounted at an angle with respect to the inlet (upstream) fluid flow, such that the blades are tilted with respect to that flow and correspondingly redirect the flow in a desired direction. The apparatus, also referred to as a “GSG” or “graduated straightening grid,” has a range of applications, and offers a number of performance, structural, and economic advantages in large-scale applications. As a particular, but non-limiting example, one or more embodiments of the flow-redirecting apparatus taught herein are configured for use in Selective Catalytic Reduction (SCR) systems where catalytic reactors are used for scrubbing industrial flue gases.

Portable storage container with cable management functionality and a method for managing cables of a portable storage container

There is provided a portable storage container with cable management functionality, including: a case constructed from a rigid material with a first extent and a second extent in an adjacent relationship therewith, the first and second extent each defining an interior space for the placement of at least one speaker driver in at least one extent, the at least one speaker driver being connected through a cable with a connector, rear portions of the first and second extent being pivotally coupled together, at least one extent having an extended rim along an edge of the interior space, the rim defining a groove along the edge of the interior space, the groove being used for aligning the cable, and a fastener for fastening edges of the first and second extent. The fastener may feed the cable into the groove when fastening the edges of the first and second extent. A corresponding method for managing at least one cable in a portable storage container is also disclosed.

Portable speakers

Flow control method and apparatus

An apparatus and method for redirecting fluid flow in a plenum provides flow performance (quality), structural, and economic advantages by using an array of flat blades that is mounted at an angle with respect to the inlet (upstream) fluid flow, such that the blades are tilted with respect to that flow and correspondingly redirect the flow in a desired direction. The apparatus, also referred to as a GSG or graduated straightening grid, has a range of applications, and offers a number of performance, structural, and economic advantages in large-scale applications. As a particular, but non-limiting example, one or more embodiments of the flow-redirecting apparatus taught herein are configured for use in Selective Catalytic Reduction (SCR) systems where catalytic reactors are used for scrubbing industrial flue gases.

METHODS TO REDUCE RADIO LINK CONTROL RETRANSMISSION

Methods, systems, and devices for wireless communications are described. A receiving device may receive, at a first operational layer of the receiving device, one or more protocol data units (PDUs) within a set of PDUs. The receiving device may identify, at a second operational layer of the receiving device, a sequence gap associated with a missing PDU from the set of PDUs, the first operational layer being a lower operational layer of the receiving device than the second operational layer. The receiving device may determine, at the second operational layer, that a triggering condition associated with the missing PDU has occurred. The receiving device may provide, by the second operational layer and based at least in part on the triggering condition occurring, an indication to update a reception buffer of the first operational layer to a last received protocol data unit of the set of PDUs.

BURIED CHANNEL FINFET SONOS WITH IMPROVED P/E CYCLING ENDURANCE

A Fin FET SONOS device is formed with a full buried channel. Embodiments include forming p-type silicon fins protruding from a first oxide layer, an n-type silicon layer over exposed surfaces of the fins, a second oxide layer, a nitride layer, and a third oxide layer sequentially on the n-type silicon layer, and a polysilicon layer on the third oxide layer. Embodiments include etching a silicon layer to form the fins and forming the oxide on the silicon layer. Different embodiments include: etching a silicon layer on a BOX layer to form the fins; forming the fins with a rounded top surface; and forming nano-wires surrounded by an n-type silicon layer, a first oxide layer, a nitride layer, a second oxide layer, and a polysilicon layer over a BOX layer. 1. A method comprising:forming p-type silicon fins protruding from a first oxide layer;forming an n-type silicon layer over exposed surfaces of the fins;forming a second oxide layer, a nitride layer, and a third oxide layer sequentially on the n-type silicon layer; andforming a polysilicon layer on the third oxide layer.2. The method according to claim 1 , comprising forming the n-type silicon layer by n-type plasma doping the fins or by epitaxially growing in-situ n-doped silicon on the fins.3. The method according to claim 2 , comprising:forming the fins in a p-type silicon substrate; andforming the first oxide layer on the p-type silicon substrate around the fins.4. The method according to claim 3 , comprising forming the first oxide layer by:depositing an oxide over the substrate and the fins; andtime etching the oxide to a thickness of 2 nm to 20 nm.5. The method according to claim 4 , comprising forming the p-type silicon fins by:forming a hard mask on the p-type silicon substrate;patterning a photoresist on the hard mask with openings;etching the p-type silicon substrate through the openings in the patterned photoresist; andremoving the photoresist.6. The method according to claim 5 , further comprising: ...

CORNER TRANSISTOR SUPPRESSION

The threshold voltage of parasitic transistors formed at corners of shallow trench isolation regions is increased and mobility decreased by employing a high-K dielectric material. Embodiments include STI regions comprising a liner of a high-K dielectric material extending proximate trench corners. Embodiments also include STI regions having a recess formed in the trench, wherein the recess contains a high-K dielectric material, in the form of a layer or spacer, extending proximate trench corners. 1. A method comprising:forming a trench, having side surfaces and a bottom surface, in a substrate;forming an oxide liner on the side surfaces and bottom surface of the trench; andforming a layer of high-K dielectric material on the oxide liner.2. The method according to claim 1 , further comprising filling the trench with an insulating material.3. The method according to claim 1 , wherein the substrate comprises a semiconductor material claim 1 , the method further comprising:forming a pad oxide layer on an upper surface of the substrate; andforming a pad nitride layer on the pad oxide layer, both prior to forming the trench in the substrate;filling the trench with insulating material forming an overburden on the pad nitride layer subsequent to forming the layer of high-K dielectric material; and 'the layer of high-K dielectric material extends proximate corners of the trench.', 'planarizing such that an upper surface of the insulating material is substantially coplanar with an upper surface of the pad nitride layer, wherein'}4. The method according to claim 3 , further comprising:removing the pad oxide and pad nitride layers from the upper surface of the substrate, leaving the filled trench as a trench isolation region; and 'the layer of high-K dielectric material increases a threshold voltage of and lowers mobility of a parasitic transistor formed at a trench corner.', 'forming transistors on the substrate separated by the trench isolation region, wherein,'}5. A method ...

Split-gate flash memory exhibiting reduced interference

A split gate memory cell is fabricated with a dielectric spacer comprising a high-k material between the word gate and the memory gate stack. Embodiments include memory cells with a dielectric spacer comprising low-k and high-k layers. Other embodiments include memory cells with an air gap between the word gate and the memory gate stack.

SPLIT-GATE FLASH MEMORY WITH IMPROVED PROGRAM EFFICIENCY

A split gate memory cell is fabricated with a word gate extending below an upper surface of a substrate having the channel region. An embodiment includes providing a band engineered channel with the word gate extending there through. Another embodiment includes forming a buried channel with the word gate extending below the buried channel. 1. A method comprising:providing a memory gate stack over a channel region; andproviding a word gate extending below an upper surface of a substrate having the channel region.2. The method according to claim 1 , comprising:forming a band engineered channel as the channel region.3. The method according to claim 2 , further comprising:forming the band engineered channel as a single layer or multiple layers;4. The method according to claim 1 , further comprising:forming a buried channel in the substrate as the channel region.5. The method according to claim 4 , further comprising:forming the buried channel 3 to 30 nm below the upper surface of the substrate.6. The method according to claim 1 , comprising:removing a portion of the memory gate stack to form an opening.7. The method according to claim 6 , comprising:forming a band engineered channel as the channel region;forming the opening through the band engineered channel; andproviding a dielectric layer and the word gate in the opening.8. The method according to claim 1 , comprising providing the word gate extending below the channel region.9. The method according to claim 6 , comprising:forming a buried channel as the channel region;forming the opening alongside of and below the buried channel; andproviding a dielectric layer and the word gate in the opening.10. The method according to claim 1 , further comprising:providing the word gate extending at least 5 nanometers below the upper surface of the substrate.11. A device comprising:a memory gate stack over a channel region; anda word gate extending below an upper surface of a substrate having the channel region.12. The device ...

DOUBLE GATED FLASH MEMORY

A split gate memory cell is fabricated with a fin structure between a memory gate stack and a select gate. Embodiments include a first channel region under the memory gate stack and a second channel region under the select gate. 1. A method comprising:providing a fin structure on a substrate;providing a memory gate stack proximate a first side surface of the fin structure; andproviding a select gate proximate a second side surface of the fin structure.2. The method according to claim 1 , comprising:providing a first channel region under the memory gate stack; andproviding a second channel region under the select gate.3. The method according to claim 2 , wherein the first channel region is for program and/or erase and the second channel region is for read.4. The method according to claim 1 , comprising providing the memory gate stack and the select gate on opposite side surfaces of the fin structure.5. The method according to claim 4 , comprising providing the fin structure by etching the substrate.6. The method according to claim 5 , comprising:etching to form the fin structure having an upper surface; depositing floating gate material on the first side surface of the fin structure;', 'depositing select gate material on the second side surface of the fin structure;', 'planarizing the floating gate material and select gate material to be substantially coplanar with the upper surface of the fin structure; and', 'depositing control gate material proximate a side surface of the floating gate material., 'providing the memory gate stack and the select gate stack by7. The method according to claim 6 , wherein the floating gate material is the same as the select gate material.8. The method according to claim 6 , comprising:oxidizing the first and second side surfaces of the fin structure prior to depositing the floating gate and select gate material; andforming a dielectric layer on a side surface of the floating gate material prior to depositing the control gate material.9 ...

N-piperidinyl acetamide derivatives as calcium channel blockers

Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted T-type calcium channel activity are disclosed. Specifically, a series of compounds containing N-piperidinyl acetamide derivatives as shown in formula (1).

INTEGRATED CIRCUITS WITH FINFET NONVOLATILE MEMORY

Integrated circuits and methods for producing the same are provided. A method for producing an integrated circuit includes forming a first and second fin overlying a substrate, where the first and second fins intersect at a fin intersection. The first fin has a first fin left end. A tunnel dielectric and a floating gate are formed adjacent to the first fin with the tunnel dielectric between the floating gate and the first fin. An interpoly dielectric is formed adjacent to the floating gate, and a control gate is formed adjacent to the interpoly dielectric such that the interpoly dielectric is between the floating gate and the control gate. The control gate, interpoly dielectric, floating gate, and the tunnel dielectric are removed from over the first fin except for at a floating gate position between the first fin left end and the fin intersection. 1. A method of producing an integrated circuit comprising:forming a first fin overlying a substrate, wherein the first fin extends in a first direction, and wherein the first fin comprises a first fin left end;forming a second fin overlying the substrate, wherein the second fin extends in a second direction different than the first direction, and wherein the second fin intersects the first fin at a fin intersection;forming a tunnel dielectric adjacent to the first fin;forming a floating gate adjacent to the first fin such that the tunnel dielectric is positioned between the floating gate and the first fin;forming an interpoly dielectric adjacent to the floating gate;forming a control gate adjacent to the interpoly dielectric such that the interpoly dielectric is positioned between the floating gate and the control gate; andremoving the control gate, the interpoly dielectric, the floating gate, and the tunnel dielectric from over the first fin except for at a floating gate position, wherein the floating gate position is between the first fin left end and the fin intersection.2. The method of further comprising:forming a ...

Systems and methods for wireless communication

Various aspects of the present disclosure generally relate to wireless communication. In some aspects, a method may include simulating a degradation of at least one of a first wireless communication link with a network or a different second wireless communication link with the network based on detecting that a first set of one or more packets, which were received via the first wireless communication link with the network and were added to a packet buffer, and a second set of one or more packets, which were received via the different second wireless communication link with the network and were added to the packet buffer, satisfy a threshold occupancy of the packet buffer. Numerous other aspects are provided.

DOUBLE GATED FLASH MEMORY

A split gate memory cell is fabricated with a fin structure between a memory gate stack and a select gate. Embodiments include a first channel region under the memory gate stack and a second channel region under the select gate.

N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS

Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted T-type calcium channel activity are disclosed. Specifically, a series of compounds containing N-piperidinyl acetamide derivatives as shown in formula (1). 2. The pharmaceutical composition of wherein Ar is substituted phenyl.3. The pharmaceutical composition of wherein n is 0.4. The pharmaceutical composition of wherein the substituents on Ar are independently selected from fluoro claim 1 , bromo claim 1 , chloro claim 1 , trifluoromethyl claim 1 , methyl claim 1 , difluoromethoxy claim 1 , trifluoromethoxy claim 1 , methylsulfonyl claim 1 , t-butyl claim 1 , t-butyloxy claim 1 , methoxy claim 1 , phenoxy claim 1 , pyrrolidinyl claim 1 , pyridinyloxy morpholinomethyl claim 1 , hydroxy claim 1 , (CH)COC(O) or wherein two optional substituents together form a five membered heterocyclic ring with Ar wherein the two substituents together form —O—CH—O— claim 1 , —O—CF—O— or —O—CHCH—.5. The pharmaceutical composition of wherein B is NY.6. The pharmaceutical composition of wherein at least one Y is H or methyl.7. The pharmaceutical composition of wherein at least one Y is an alkyl or heteroalkyl.8. The pharmaceutical composition of wherein a carbonyl is immediately adjacent to the N in B.9. The pharmaceutical composition of wherein each R is H claim 1 , or two R on the same carbon atom together form ═O.11. The pharmaceutical composition of wherein one Y is H or methyl and one Y is an optionally substituted alkyl (1-6C) or SORwherein Ris an optionally substituted C1-C5 alkyl. This application is a continuation of U.S. patent application Ser. No. 13/601,357, filed Aug. 31, 2012, which is a continuation of U.S. patent application Ser. No. 12/420,793, filed Apr. 8, 2009, which claims benefit to U.S. Provisional Application No. 61/058,179, filed Jun. 2, 2008, each of which is hereby incorporated by reference in its entirety.The invention relates ...

RECONFIGURABLE CONTROL DEVICE

A reconfigurable control device, in particular for use in a vehicle. Input keys on the reconfigurable control device allow a user to trigger different selection of modes. The control device is reconfigured by performing a first step of selecting a function mode by pressing one of the at least two input keys on the control device and a second step of selecting a function displayed on an array of mechanical switches. The selection of functions is refreshed with user trigger a fresh selection of mode. 1. A reconfigurable control device , for use in vehicles , comprising:a display for supplying text and/or graphic information;an array of mechanical switches having at least an opaque portion,a housing unit, a surface of the housing unit comprising:a display opening for viewing a second section of the display-means;a recess for receiving the array of mechanical switches;at least two outlets, each of the at least two outlets for retaining at least one input key; andan electronic control unit for retrieving information from the array of mechanical switches and the input keys, wherein the at least one input key is configured for selecting a plurality of predetermined modes, and the array of mechanical switches are each configured for supplying a plurality of predetermined functions, and wherein the array of mechanical switches partially covers the first section of the display and the electronic control unit.2. The reconfigurable control device of claim 1 , wherein the opaque portion overlaying the first section which displays text and/or graphic information represents the plurality of predetermined functions.3. The reconfigurable control device of claim 1 , wherein selecting the at least one input key initiates a command from the electronic control unit for retrieving information in relation to the plurality of predetermined modes.4. The reconfigurable control device of claim 1 , wherein the array of mechanical switches is reconfigured when a subsequent command from the ...

SPLIT-GATE FLASH MEMORY WITH IMPROVED PROGRAM EFFICIENCY

A split gate memory cell is fabricated with a word gate extending below an upper surface of a substrate having the channel region. An embodiment includes providing a band engineered channel with the word gate extending there through. Another embodiment includes forming a buried channel with the word gate extending below the buried channel. 1. A device comprising:a memory gate stack over a channel region; anda word gate having an uppermost surface in an upper portion and a lower surface in a lower portion, the word gate extending from the uppermost surface at an upper surface of the memory gate stack to the lower surface of the word gate below an upper surface of a substrate at source and drain regions,wherein the upper portion of the word gate and the lower portion of the word gate have the same width, andwherein the upper surface of the memory gate stack and the uppermost surface of the word gate are substantially coplanar.2. The device according to claim 1 , further comprising a band engineered channel as the channel region.3. The device according to claim 2 , wherein the band engineered channel comprises one or more layers.4. The device according to claim 1 , wherein the channel region comprises a buried channel in the substrate.5. The device according to claim 2 , comprising an opening through the channel region claim 2 , wherein the word gate is formed in the opening.6. The device according to claim 1 , wherein the word gate extends below the channel region.7. The device according to claim 1 , including a split gate non-volatile memory device claim 1 , the split-gate non-volatile memory device comprising the memory gate stack and the word gate.8. A device comprising:a memory gate stack over a channel region;an opening formed in the memory gate stack;a word gate, having an uppermost surface in an upper portion and a lower surface in a lower portion, the word gate having sidewall spacers on side surfaces thereof and the word gate extending from the upper surface ...

MTP MEMORY FOR SOI PROCESS

Embodiments of a multi-time programmable (MTP) structure for non-volatile memory cells are presented. The memory cell includes an ultra-thin silicon-on-insulator (SOI) substrate. A transistor having a floating gate is disposed on the SOI substrate. The transistor comprises first and second source/drain (S/D) regions disposed adjacent to sides of the floating gate. A control capacitor having a control gate is disposed on the SOI substrate. The control gate is directly coupled to the floating gate. A device well is disposed in the base substrate and underlaps the floating gate and the control gate. A capacitor back-gate is embedded within the base substrate and in electrical communication with the control gate. A contact region is disposed within the device well. 1. A non-volatile (NV) multi-time programmable (MTP) memory cell comprising:a silicon-on-insulator (SOI) substrate having a body substrate disposed over a base substrate, wherein a buried oxide (BOX) layer is disposed between the base substrate and the body substrate;an active region defined in the SOI substrate, wherein the active region comprises a transistor region and a capacitor region;a gate structure disposed on the SOI substrate, the gate structure comprises a gate electrode layer disposed over a gate dielectric layer, wherein the gate structure extends continuously across the active region to overlap the transistor region and the capacitor region, wherein a first portion of the gate structure defines a transistor gate and a second portion of the gate structure defines a capacitor gate;a first polarity type device well disposed in the base substrate, wherein the device well traverses the transistor region and the capacitor region, the device well underlaps the transistor gate and the capacitor gate;first and second doped regions disposed within the capacitor region, wherein the first doped region is disposed in the body substrate and the second doped region is disposed in the base substrate within the ...

CUSTOMISABLE STOMA INSERT

The invention relates to method of manufacturing a custom stoma insert for a patient having a stoma, as well as to a stoma made using the method of the invention. The method comprises the steps of scanning the stoma and surrounding skin area to generate a three-dimensional scan of the area for which the stoma insert is to be manufactured; manipulating scan data obtained from the three-dimensional scan to render a three-dimensional model of the stoma and surrounding skin contours, such that the scan data is suitable for use in an additive manufacturing environment; creating a custom mould for the stoma insert using additive manufacturing such that the mould provides a complementary surface closely mirroring the contours of the stoma and surrounding skin area; and producing the stoma insert by casting a physiologically acceptable mouldable material into the custom mould. 1. A method of manufacturing a custom stoma insert for a patient having a stoma , the method comprising the steps of:scanning the stoma and surrounding skin area to generate a three-dimensional scan of the area for which the stoma insert is to be manufactured;manipulating scan data obtained from the three-dimensional scan to render a three-dimensional model of stoma and surrounding skin contours, such that the scan data is suitable for use in an additive manufacturing environment;creating a custom mould for the stoma insert using additive manufacturing such that the mould provides a complementary surface closely mirroring the contours the stoma and surrounding skin area; andproducing the stoma insert by casting a physiologically acceptable mouldable material into the custom mould, allowing the mouldable material to solidify to a desired solidity, and removing the custom stoma insert from the mould, the resultant custom stoma insert being shaped and dimensioned to ensure a snug fit within the stoma and over the skin surrounding the stoma.2. The method of claim 1 , wherein the step of creating the ...

Antibiotic Compounds, Pharmaceutical Formulations Thereof And Methods And Uses Therefor

The present invention relates to compounds of formula (I) wherein G 1 to G 8 are as defined herein. The compounds are PK inhibitors and as such represent a new approach to treating pathogenic infections, including multidrug resistant pathogens. Disclosed herein are the compounds of formula (I), pharmaceutical compositions comprising the compounds of formula (I) and their use in the treatment of antimicrobial infection. (Formula (1))

High gain transistor for analog applications

An analog high gain transistor is disclosed. The formation of the analog high gain transistor is highly compatible with existing CMOS processes. The analog high gain transistor includes a double well, which includes the well implants of the low voltage (LV) and intermediate voltage (IV) transistors. In addition, the analog high gain transistor includes light doped extension regions of IV transistor and a thin gate dielectric of the LV transistor.

N-piperidinyl acetamide derivatives as calcium channel blockers

Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted T-type calcium channel activity, are disclosed Specifically, a series of compounds which are N-piperidinyl acetamide derivatives as shown in formula (1) are disclosed as calcium ion channel activating modulators Compositions comprising these compounds and the use of these compounds in the treatment or prevention of conditions such as obesity are also disclosed.

Bicyclic pyrimidine derivatives as calcium channel blockers

Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted T-type calcium channel activity are disclosed. Specifically, a series of compounds containing thienopyrimidine or oxoquinazoline derivatives are disclosed of the general formula (1) or formula (2) where X is a linker and Y is an aromatic moiety or N(R5)(R6).

Acetamide N-piperidinyl derivatives as calcium channel blockers

Un compuesto con la estructura: **Fórmula** o una sal farmacéuticamente aceptable de los mismos, para uso en el tratamiento del dolor crónico o agudo. A compound with the structure: ** Formula ** or a pharmaceutically acceptable salt thereof, for use in the treatment of chronic or acute pain.

Canal dilation device

A device for enlarging a canal of a human or animal subject includes an elongate member having a first lumen extending therein and an inflatable body toward a distal end of the elongate member. The inflatable body is deliverable, in an uninflated or deflated state, to a location substantially within the canal prior to inflation. The first lumen is in communication with the inflatable body via one or more channels therebetween. In use, the first lumen is in communication, toward a proximal end, with an inflation system for delivering fluid to inflate the inflatable body and thereby enlarging the canal. The device may include markings for sounding of e.g. uterine depth. The device may also include one or more projections, or other means providing tactile cues during positioning of the device within the canal and these may also be configured to aid in removal of cells from a tissue wall.

N-piperidinyl acetamide derivatives as calcium channel blockers

A flow control method and apparatus

The disclosure relates to air pollution control, and specifically to an apparatus for redirecting fluid flow in a plenum to improve flow performance and, therefore, improved air pollution control, especially in selective catalytic NO x reduction. The apparatus employs an array of flat blades mounted at an angle with respect to the inlet (upstream) fluid flow, such that the blades are titled with respect to that flow and correspondingly redirect the flow in a desired direction. The apparatus, which can also referred to as a 'GSG' or 'graduated straightening grid,' has a range of applications, and offers a number of performance, structural, and economic advantages in large-scale applications.

A flow control method and apparatus

4-(aminomethyl)cyclohexanamine derivatives as calcium channel blockers

Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted T-type calcium channel activity are disclosed. Specifically, a series of compounds containing 4--(aminomethyl)cyclohexanamine derivatives as shown in formula (1).

A flow control method and apparus summary

THE DISCLOSURE RELATES TO AIR POLLUTION CONTROL, AND SPECIFICALLY TO AN APPARATUS FOR REDIRECTING FLUID FLOW IN A PLENUM TO IMPROVE FLOW PERFORMANCE AND, THEREFORE, IMPROVED AIR POLLUTION CONTROL, ESPECIALLY IN SELECTIVE CATALYTIC NOX REDUCTION. THE APPARATUS EMPLOYS AN ARRAY OF FLAT BLADES MOUNTED AT AN ANGLE WITH RESPECT TO THE INLET (UPSTREAM) FLUID FLOW, SUCH THAT THE BLADES ARE TITLED WITH RESPECT TO THAT FLOW AND CORRESPONDINGLY REDIRECT THE FLOW IN A DESIRED DIRECTION. THE APPARATUS, WHICH CAN ALSO REFERRED TO AS A ?GSG? OR ?GRADUATED STRAIGHTENING GRID,? HAS A RANGE OF APPLICATIONS, AND OFFERS A NUMBER OF PERFORMANCE, STRUCTURAL, AND ECONOMIC ADVANTAGES IN LARGE-SCALE APPLICATIONS.

MTP memory for SOI process

Embodiments of a multi-time programmable (MTP) structure for non-volatile memory cells are presented. The memory cell includes an ultra-thin silicon-on-insulator (SOI) substrate. A transistor having a floating gate is disposed on the SOI substrate. The transistor comprises first and second source/drain (S/D) regions disposed adjacent to sides of the floating gate. A control capacitor having a control gate is disposed on the SOI substrate. The control gate is directly coupled to the floating gate. A device well is disposed in the base substrate and underlaps the floating gate and the control gate. A capacitor back-gate is embedded within the base substrate and in electrical communication with the control gate. A contact region is disposed within the device well.

Bicyclic pyrimidine derivatives as calcium channel blockers

Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted T-type calcium channel activity are disclosed. Specifically, a series of compounds containing thienopyrimidine or oxoquinazoline derivatives are disclosed of the general formula (1) or formula (2) where X is a linker and Y is an aromatic moiety or N(R5)(R6).

Memory device with fin structure and double gate and method of manufacturing the same

Verfahren, das die folgenden Schritte umfasst:Schaffen einer Rippenstruktur (207) auf einem Substrat (201);Bilden einer dielektrischen Schicht (205) nach dem Schaffen der Rippenstruktur (207), sodass die dielektrische Schicht (205) seitlich von der Rippenstruktur (207) auf dem Substrat angeordnet ist;Schaffen eines Speicher-Gate-Stapels (209) über der dielektrischen Schicht (205) benachbart zu einer ersten Seitenfläche der Rippenstruktur (207);Schaffen eines Auswahl-Gates (211) über der dielektrischen Schicht (205) benachbart zu einer zweiten Seitenfläche der Rippenstruktur (207);Schaffen eines ersten Kanalbereichs (215) unter dem Speicher-Gate-Stapel (209); undSchaffen eines zweiten Kanalbereichs (217) unter dem Auswahl-Gate (211), wobei der erste Kanalbereich (215) dem Programmieren und/oder dem Löschen dient und der zweite Kanalbereich (217) dem Lesen dient. A method comprising the steps of: creating a rib structure (207) on a substrate (201); forming a dielectric layer (205) after creating the rib structure (207) such that the dielectric layer (205) is lateral to the rib structure (207 ) disposed on the substrate;providing a storage gate stack (209) over the dielectric layer (205) adjacent a first side surface of the fin structure (207);providing a select gate (211) over the dielectric layer (205) adjacent a second side surface of the fin structure (207); creating a first channel region (215) under the memory gate stack (209); and providing a second channel area (217) under the select gate (211), the first channel area (215) being for programming and/or erasing and the second channel area (217) being for reading.

A flow control method and apparatus

The disclosure relates to air pollution control, and specifically to an apparatus for redirecting fluid flow in a plenum to improve flow performance and, therefore, improved air pollution control, especially in selective catalytic NOx reduction. The apparatus employs an array of flat blades mounted at an angle with respect to the inlet (upstream) fluid flow, such that the blades are titled with respect to that flow and correspondingly redirect the flow in a desired direction. The apparatus, which can also referred to as a 'GSG' or 'graduated straightening grid,' has a range of applications, and offers a number of performance, structural, and economic advantages in large-scale applications.

Layered missing packet detection

A wireless communication device is described. The wireless communication device includes a memory and a processor in electronic communication with the memory. The processor is configured to determine a packet data convergence protocol (PDCP) acket count corresponding to a last radio link control (RLC) packet received in-sequence. The processor is also configured to detect a missing PDCP packet based on a comparison of the PDCP packet count and a sequence number of a last PDCP packet received in-sequence.

Floating combi-bar and mixture for producing same

Described is a mixture for producing a combi-bar floating in water at 20° C. (floating combi-bar), the mixture comprising or (essentially) consisting of: v) 20-50 wt. %, preferably 25-40 wt. %, of one or more non-soap surfactants, preferably solid non-soap surfactants, vi) 25-60 wt. %, preferably 35-55 wt. %, of one or more free C 14 -C 18 fatty acids, vii) 2-40 wt. %, preferably 5-25 wt. %, of one or more metal C 8 -C 24 fatty acid soaps, and viii) 0-20 wt. %, preferably 2-20 wt. %, of further ingredients, said mixture containing less than 10 wt. % of water as a further ingredient. Further described are methods for producing a combi-bar and a combi-bar itself.

Simple and cost-free MTP structure

Non-volatile (NV) Multi-time programmable (MTP) memory cells are presented. The memory cell includes a substrate and first and second wells in the substrate. The memory cell includes first transistor having a select gate, second transistor having a floating gate adjacent to one another and on the second well, and third transistor having a control gate on the first well. The control gate is coupled to the floating gate and the control and floating gates include the same gate layer extending across the first and second wells. The transistors include first and second diffusion regions disposed adjacent to sides of the gates. The first and second diffusion regions include base lightly doped drain (LDD) and halo regions. One of the first and second diffusion regions of one of the second and third transistors includes second LDD and halo regions having higher dopant concentrations than the base LDD and halo regions.

High gain transistor for analog applications

An analog high gain transistor is disclosed. The formation of the analog high gain transistor is highly compatible with existing CMOS processes. The analog high gain transistor includes a double well, which includes the well implants of the low voltage (LV) and intermediate voltage (IV) transistors. In addition, the analog high gain transistor includes light doped extension regions of IV transistor and a thin gate dielectric of the LV transistor.

Compositions for promoting readthrough of premature termination codons, and methods of using the same

Disclosed are compounds of general formula (I) that promote readthrough of a premature termination codon (PTC) of an RNA molecule in a translation system, and their use, alone or in combination with other compounds, such as aminoglycoside, to treat diseases or disorders ameliorated by modulation of a premature termination codon (PTC) of an RNA molecule in a translation system. The disorder or disease may be Dystrophic epidermolysis bullosa, Batten disease, Duchenne muscular dystrophy, cancer, and spinal muscular atrophy. Ar-L-B (I)

N-piperidinyl acetamide derivatives as calcium channel blockers

Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted T-type calcium channel activity, are disclosed Specifically, a series of compounds which are N-piperidinyl acetamide derivatives as shown in formula (1) are disclosed as calcium ion channel activating modulators Compositions comprising these compounds and the use of these compounds in the treatment or prevention of conditions such as obesity are also disclosed.

Adjustable silk sleeve for cots / cribs

The disclosed sleeve for cot / crib mattresses is a fabric band with a smooth material on top so that there is no friction created against a baby's head or hair. Stretch fabric and fasteners on the underside of the sleeve allow for the sleeve to be adjusted so that it can snugly fit a variety of mattress sizes without any excess fabric being loose. ADJUSTABLE SILK SLEEVE FOR COTS /CRIBS (TOP VIEW) ADJUSTABLE SILK SLEEVE FOR COTS /CRIBS (BOTTOM VIEW)

7-morpholino-1,6-naphthyridin-5-yl derivatives and pharmaceutical compositions thereof useful as dna-pk inhibitor

The present disclosure provides compounds and methods for inhibiting DNA-dependent protein kinase (DNA-PK). Aspects of the present disclosure also include methods of using the compounds to treat diseases, including, but not limited to, cancer. In certain embodiments, the compounds inhibit DNA-PK and thus sensitize cancers to therapies such as chemotherapy and radiotherapy. Certain compounds of the present disclosure are in the form of prodrugs that release the DNA-PK inhibitor in hypoxic tissue such as is known to occur in cancers. Aspects of the present disclosure also include methods of using the compounds for repairing a DNA break in a target genomic region or for modifying expression of one or more genes or proteins. Compounds provided are of formula: (II)

Dna-pk inhibitor compounds and uses thereof

Provided are compounds and method for inhibiting DNA-dependent protein kinase (DNA-PK). Aspects of the present disclosure also include methods of using the compounds to treat disease, including, but not limited to, cancer. In certain embodiments, the compounds inhibit DNA-PK and thus sensitize cancers to therapies such as chemotherapy and radiotherapy. Compounds provided are of Formula (I).

Fluorinated cationic lipids for use in lipid nanoparticles

Compounds are provided having the following structure: (I) or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R3, L1, L2, G1, G2 and G3 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.

7-morpholino-l,6-naphthyridin-5-yl derivatives and pharmaceutical compositions thereof useful as dna-pk inhibitor

The present disclosure provides compounds and methods for inhibiting DNA-dependent protein kinase (DNA-PK). Aspects of the present disclosure also include methods of using the compounds to treat diseases, including, but not limited to, cancer. In certain embodiments, the compounds inhibit DNA-PK and thus sensitize cancers to therapies such as chemotherapy and radiotherapy. Certain compounds of the present disclosure are in the form of prodrugs that release the DNA-PK inhibitor in hypoxic tissue such as is known to occur in cancers. Aspects of the present disclosure also include methods of using the compounds for repairing a DNA break in a target genomic region or for modifying expression of one or more genes or proteins. Compounds provided are of formula.

Customizable stoma insert

The disclosure relates to a method of manufacturing a custom stoma insert for a patient having a stoma, as well as to a stoma made using the method of the disclosure. The method comprises the steps of scanning the stoma and surrounding skin area to generate a three-dimensional scan of the area for which the stoma insert is to be manufactured; manipulating scan data obtained from the three-dimensional scan to render a three-dimensional model of the stoma and surrounding skin contours, such that the scan data is suitable for use in an additive manufacturing environment; creating a custom mold for the stoma insert using additive manufacturing such that the mold provides a complementary surface closely mirroring the contours of the stoma and surrounding skin area; and producing the stoma insert by casting a physiologically acceptable moldable material into the custom mold.

Adjustable Silk Fitted Sheet for Baby Mattresses and Baby Loungers

The disclosed sheet for baby mattresses and baby loungers is a fitted sheet with a smooth material on top so that there is no friction created against a baby's head or hair. Stretch fabric on the underside of the sheet and an adjustable cord allow for the sheet to snugly and securely fit a variety of baby mattresses and loungers without any excess fabric being loose. DRAWINGS ADJUSTABLE SILK FITTED SHEET FOR BABY MATTRESSES AND BABY LOUNGERS (TOP VIEW) ADJUSTABLE SILK FITTED SHEET FOR BABY MATTRESSES AND BABY LOUNGERS (BOTTOM VIEW)

Lipids for use in lipid nanoparticle formulations

Compounds are provided having the following structure: (I) or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R3, L1, L2, G1, G2 and G3 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.

7-morpholino-l,6-naphthyridin-5-yl derivatives and pharmaceutical compositions thereof useful as dna-pk inhibitor

The present disclosure provides compounds and methods for inhibiting DNA-dependent protein kinase (DNA-PK). Aspects of the present disclosure also include methods of using the compounds to treat diseases, including, but not limited to, cancer. In certain embodiments, the compounds inhibit DNA-PK and thus sensitize cancers to therapies such as chemotherapy and radiotherapy. Certain compounds of the present disclosure are in the form of prodrugs that release the DNA-PK inhibitor in hypoxic tissue such as is known to occur in cancers. Aspects of the present disclosure also include methods of using the compounds for repairing a DNA break in a target genomic region or for modifying expression of one or more genes or proteins. Compounds provided are of formula.

Hyper frame number (hfn) resynchronization of packet data convergence protocol (pdcp) protocol data units

Aspects of the present disclosure provide mechanisms for fast hyper frame number (HFN) resynchronization of Packet Data Convergence Protocol (PDCP) Protocol Data Units (PDUs). A wireless communication device (e.g., a PDCP entity at a wireless communication device) can calculate a current PDCP count of a current PDCP PDU of a plurality of PDCP PDUs received from a radio link control (RLC) sublayer based on a PDCP sequence number (SN) of the current PDCP PDU and an HFN of a first missing PDCP PDU after a successfully received PDCP PDU. The PDCP count may be calculated using the HFN of the first missing PDCP PDU in response to a gap between the PDCP count of the first missing PDCP PDU and the actual PDCP count of the current PDCP PDU being greater than a PDCP window size.

7-morpholino-1,6-naphthyridin-5-yl derivatives and pharmaceutical compositions thereof useful as dna-pk inhibitor

The present disclosure provides compounds and methods for inhibiting DNA-dependent protein kinase (DNA-PK). Aspects of the present disclosure also include methods of using the compounds to treat diseases, including, but not limited to, cancer. In certain embodiments, the compounds inhibit DNA-PK and thus sensitize cancers to therapies such as chemotherapy and radiotherapy. Certain compounds of the present disclosure are in the form of prodrugs that release the DNA-PK inhibitor in hypoxic tissue such as is known to occur in cancers. Aspects of the present disclosure also include methods of using the compounds for repairing a DNA break in a target genomic region or for modifying expression of one or more genes or proteins. Compounds provided are of formula: (II)

Methods to reduce radio link control retransmission

Methods, systems, and devices for wireless communications are described. A receiving device may receive, at a first operational layer of the receiving device, one or more protocol data units (PDUs) within a set of PDUs. The receiving device may identify, at a second operational layer of the receiving device, a sequence gap associated with a missing PDU from the set of PDUs, the first operational layer being a lower operational layer of the receiving device than the second operational layer. The receiving device may determine, at the second operational layer, that a triggering condition associated with the missing PDU has occurred. The receiving device may provide, by the second operational layer and based at least in part on the triggering condition occurring, an indication to update a reception buffer of the first operational layer to a last received protocol data unit of the set of PDUs.

Systems and methods for wireless communication

Various aspects of the present disclosure generally relate to wireless communication. In some aspects, a method may include simulating a degradation of at least one of a first wireless communication link with a network or a different second wireless communication link with the network based on detecting that a first set of one or more packets, which were received via the first wireless communication link with the network and were added to a packet buffer, and a second set of one or more packets, which were received via the different second wireless communication link with the network and were added to the packet buffer, satisfy a threshold occupancy of the packet buffer. Numerous other aspects are provided.

Customisable stoma insert

The invention relates to method of manufacturing a custom stoma insert for a patient having a stoma, as well as to a stoma made using the method of the invention. The method comprises the steps of scanning the stoma and surrounding skin area to generate a three-dimensional scan of the area for which the stoma insert is to be manufactured; manipulating scan data obtained from the three- dimensional scan to render a three-dimensional model of the stoma and surrounding skin contours, such that the scan data is suitable for use in an additive manufacturing environment; creating a custom mould for the stoma insert using additive manufacturing such that the mould provides a complementary surface closely mirroring the contours of the stoma and surrounding skin area; and producing the stoma insert by casting a physiologically acceptable mouldable material into the custom mould.

Customisable stoma insert

Digital assistant human-machine interaction device

A digital assistant device (10) comprises: input means (12, 14) configured to acquire information from a plurality of users in a predetermined area around the digital assistant device (10) and to output signals indicative of the acquired information, processing means (16) configured to receive the signals output by the input means (12, 14) and to generate individual user output information for several or each of the users, and output means (18) configured to output the generated output information uniquely assigned to a particular user in a user-characteristic way.

Digital assistant human-machine interaction device

A digital assistant device (10) comprises: input means (12, 14) configured to acquire information from a plurality of users in a predetermined area around the digital assistant device (10) and to output signals indicative of the acquired information, processing means (16) configured to receive the signals output by the input means (12, 14) and to generate individual user output information for several or each of the users, and output means (18) configured to output the generated output information uniquely assigned to a particular user in a user-characteristic way.

Digital assistant human-machine interaction device

A digital assistant device 10 comprises: input means 12, 14 configured to acquire information from a plurality of users in a predetermined area around the digital assistant device and to output signals indicative of the acquired information, processing means 16 configured to receive the signals output by the input means and to generate individual user output information for several or each of the users, and output means 18 configured to output the generated output information uniquely assigned to a particular user in a user-characteristic way. The processing means may also be configured to determine the positions of a number of users relative to the digital assistant device from the signals output by the input means. The digital assistant device may include a display configured to output information uniquely assigned to a particular user in a user assigned display portion. The digital assistant device may be configured as an in-car digital assistant device.

Customisable stoma insert

Systems and methods for wireless communication

Various aspects of the present disclosure generally relate to wireless communication. In some aspects, a method may include simulating a degradation of at least one of a first wireless communication link with a network or a different second wireless communication link with the network based on detecting that a first set of one or more packets, which were received via the first wireless communication link with the network and were added to a packet buffer, and a second set of one or more packets, which were received via the different second wireless communication link with the network and were added to the packet buffer, satisfy a threshold occupancy of the packet buffer. Numerous other aspects are provided.

Systems and methods for wireless communication

Red-green-blue, vertical-cavity, surface-emitting laser array

This disclosure describes a red-green-blue (RGB) vertical-cavity surface-emitting laser (VCSEL) array. Each VCSEL in the VCSEL array has a grating, one or more active regions and two distributed Bragg reflectors. Each VCSEL corresponds to either red, green or blue wavelengths. The number of active regions in each VCSEL may be based on the color emitted.

A portable storage container with cable management functionality and a method for managing cables of a portable storage container

Tragbarer aufbewahrungscontainer mit kabelverwaltungsfunktionalität und verfahren zur verwaltung von kabeln eines tragbaren aufbewahrungscontainers

Techniques for packet data convergence protocol reordering within a timer

Various aspects of the present disclosure generally relate to wireless communication. In some aspects, a receiver device may receive a first packet of a plurality of packets included in a reordering window of the receiver device. The receiver device may receive a second packet of the plurality of packets. The receiver device may provide the first packet and the second packet based at least in part on expiration of a reordering timer. The receiver device may receive a third packet of the plurality of packets at a third time, wherein the first packet, the second packet, and the third packet are received sequentially. The receiver device may provide a set of packets including the first packet, the third packet, and the second packet in order, to a higher layer in accordance with a timer that is shorter than a length of the reordering window. Numerous other aspects are described.

Techniques for packet data convergence protocol ordering after expiration of a timer

Various aspects of the present disclosure generally relate to wireless communication. In some aspects, a receiver device may receive a first packet of a plurality of packets included in a reordering window of the receiver device. The receiver device may receive a second packet of the plurality of packets. The receiver device may provide the first packet and the second packet based at least in part on expiration of a reordering timer. The receiver device may receive a third packet of the plurality of packets at a third time, wherein the first packet, the second packet, and the third packet are received sequentially. The receiver device may provide a set of packets including the first packet, the third packet, and the second packet in order, to a higher layer in accordance with a timer that is shorter than a length of the reordering window. Numerous other aspects are described.

Systems and methods for wireless communication

Various aspects of the present disclosure generally relate to wireless communication. In some aspects, a method may include simulating a degradation of at least one of a first wireless communication link with a network or a different second wireless communication link with the network based on detecting that a first set of one or more packets, which were received via the first wireless communication link with the network and were added to a packet buffer, and a second set of one or more packets, which were received via the different second wireless communication link with the network and were added to the packet buffer, satisfy a threshold occupancy of the packet buffer. Numerous other aspects are provided.

Techniques for packet data convergence protocol reordering within a timer

Various aspects of the present disclosure generally relate to wireless communication. In some aspects, a receiver device may receive a first packet of a plurality of packets included in a reordering window of the receiver device. The receiver device may receive a second packet of the plurality of packets. The receiver device may provide the first packet and the second packet based at least in part on expiration of a reordering timer. The receiver device may receive a third packet of the plurality of packets at a third time, wherein the first packet, the second packet, and the third packet are received sequentially. The receiver device may provide a set of packets including the first packet, the third packet, and the second packet in order, to a higher layer in accordance with a timer that is shorter than a length of the reordering window. Numerous other aspects are described.

Fluorinated cationic lipids for use in lipid nanoparticles

Compounds are provided having the following structure: (I) or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R3, L1, L2, G1, G2 and G3 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.

Lipids for use in lipid nanoparticle formulations

Compounds are provided having the following structure: (I) or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R3, L1, L2, G1, G2 and G3 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.

Techniques for packet data convergence protocol ordering after expiration of a timer

Various aspects of the present disclosure generally relate to wireless communication. In some aspects, a receiver device may receive a first packet of a plurality of packets included in a reordering window of the receiver device. The receiver device may receive a second packet of the plurality of packets. The receiver device may provide the first packet and the second packet based at least in part on expiration of a reordering timer. The receiver device may receive a third packet of the plurality of packets at a third time, wherein the first packet, the second packet, and the third packet are received sequentially. The receiver device may provide a set of packets including the first packet, the third packet, and the second packet in order, to a higher layer in accordance with a timer that is shorter than a length of the reordering window. Numerous other aspects are described.

Polarized/lensed back-side emitting (bse) vertical-cavity surface-emitting laser (vcsel)

This disclosure describes a vertical-cavity surface-emitting laser (VCSEL) structure with a locked polarization and collimating optical element. The VCSEL structure comprises a grating, an optical emitter such as a lens and a plurality of GaAs/AlGaAs mirrors between the grating and the optical emitter. The grating located between the mirror stacks and above or below the active region is able to polarize incident waves of the VCSEL structure.

Red-green-blue, vertical-cavity, surface-emitting laser array

This disclosure describes a red-green-blue (RGB) vertical-cavity surface-emitting laser (VCSEL) array. Each VCSEL in the VCSEL array has a grating, one or more active regions and two distributed Bragg reflectors. Each VCSEL corresponds to either red, green or blue wavelengths. The number of active regions in each VCSEL may be based on the color emitted.

An entertainment system for a motor vehicle and method thereof

An entertainment system for implementation into a motor vehicle is disclosed. The entertainment system includes an interactive transparent display, at least one image sensing device and a microcontroller.The interactive display is operable to provide a view outside the motor vehicle. The at least one image sensing device captures one or more images of the view outside the motor vehicle. The microcontroller is operable to identify a motion signal and execute a command to take a picture based on the motion signal identified.The interactive transparent display operates as an interface to receive the motion signal to take the picture. A method of operating the entertainment system is also disclosed.

Polarized/lensed back-side emitting (bse) vertical-cavity surface-emitting laser (vcsel)

This disclosure describes a vertical-cavity surface-emitting laser (VCSEL) structure with a locked polarization and collimating optical element. The VCSEL structure comprises a grating, an optical emitter such as a lens and a plurality of GaAs/AlGaAs mirrors between the grating and the optical emitter. The grating located between the mirror stacks and above or below the active region is able to polarize incident waves of the VCSEL structure.

Ν-πιπεριδινυλ ακεταμιδιου παραγωγα ως αναστολεις διαυλου ασβεστιου

Αποκαλύπτονται μέθοδοι και ενώσεις αποτελεσματικές στη βελτίωση καταστάσεων που χαρακτηρίζονται από ανεπιθύμητη δραστικότητα διαύλου ασβεστίου, ιδιαιτέρως ανεπιθύμητη Τ-τύπου δραστικότητα διαύλου ασβεστίου. Ειδικώς, μία σειρά ενώσεων που είναι Ν-πιπεριδινύλ ακεταμιδίου παράγωγα όπως δείχνεται στον τύπο (1) αποκαλύπτονται ως ρυθμιστές ενεργοποίησης διαύλου ιόντος ασβεστίου. Επίσης αποκαλύπτονται συνθέσεις που περιλαμβάνουν αυτές τις ενώσεις και η χρήση αυτών των ενώσεων στη θεραπεία ή την αποτροπή καταστάσεων όπως επιληψίας.

Lipids for use in lipid nanoparticle formulations

Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R 3 , L 1 , L 2 , G 1 , G 2 and G 3 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.

偏光／レンズ付き背面発光式（ｂｓｅ）垂直共振器型面発光レーザー（ｖｃｓｅｌ）

【課題】ロックされた偏光・視準光学素子を備える垂直共振器型面発光レーザー（ＶＣＳＥＬ）構造を提供すること。【解決手段】ＶＣＳＥＬ構造が、格子と、レンズなどの光学エミッタと、格子と光学エミッタとの間にある複数のＧａＡｓ／ＡｌＧａＡｓミラーと、を備える。ミラースタックの間に位置してさらには活性領域の上方または下方に位置する格子が、ＶＣＳＥＬ構造の入射波を偏光させることができる。【選択図】図１

Polarized/lensed back-side emitting (bse) vertical-cavity surface-emitting laser (vcsel)

This disclosure describes a vertical-cavity surface-emitting laser (VCSEL) structure with a locked polarization and collimating optical element. The VCSEL structure comprises a grating, an optical emitter such as a lens and a plurality of GaAs/AlGaAs mirrors between the grating and the optical emitter. The grating located between the mirror stacks and above or below the active region is able to polarize incident waves of the VCSEL structure.

Bærbar opbevaringsbeholder med kabelhåndteringsfunktion og fremgangsmåde til håndtering af kabler fra en bærbar opbevaringsbeholder

7-Morpholino-1,6-Naphthyridin-5-yl Derivatives and Pharmaceutical Compositions Thereof Useful as DNA-PK Inhibitor

The present disclosure provides compounds and methods for inhibiting DNA-dependent protein kinase (DNA-PK). Aspects of the present disclosure also include methods of using the compounds to treat diseases, including, but not limited to, cancer. In certain embodiments, the compounds inhibit DNA-PK and thus sensitize cancers to therapies such as chemotherapy and radiotherapy. Certain compounds of the present disclosure are in the form of prodrugs that release the DNA-PK inhibitor in hypoxic tissue such as is known to occur in cancers. Aspects of the present disclosure also include methods of using the compounds for repairing a DNA break in a target genomic region or for modifying expression of one or more genes or proteins. Compounds provided are of formula: (II)

Digital assistant human-machine interaction device

A digital assistant device comprises an input component configured to acquire information from a plurality of users in a predetermined area around the digital assistant device and to output signals indicative of the acquired information, a processing component configured to receive the signals output by the input component and to generate individual user output information for several or each of the users, and an output component configured to output the generated output information uniquely assigned to a particular user in a user-characteristic way.

7-Morpholino-L,6-Naphthyridin-5-yl Derivatives and Pharmaceutical Compositions Thereof Useful as DNA-PK Inhibitor

The present disclosure provides compounds and methods for inhibiting DNA-dependent protein kinase (DNA-PK). Aspects of the present disclosure also include methods of using the compounds to treat diseases, including, but not limited to, cancer. In certain embodiments, the compounds inhibit DNA-PK and thus sensitize cancers to therapies such as chemotherapy and radiotherapy. Certain compounds of the present disclosure are in the form of prodrugs that release the DNA-PK inhibitor in hypoxic tissue such as is known to occur in cancers. Aspects of the present disclosure also include methods of using the compounds for repairing a DNA break in a target genomic region or for modifying expression of one or more genes or proteins. Compounds provided are of formula.

Fluorinated cationic lipids for use in lipid nanoparticles

Compounds are provided having the following structure: (I) or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R2a, R2b, R3a, R3b, R7, R8, R9, L1, L2, G1, G2, G3, b, and c are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.

Ostomy custom skin barrier method and system

Prompt configuration for llm integrations in spreadsheet environments

Technology is disclosed herein for an application service which interfaces with an LLM service. In an implementation, the application service receives a natural language input from a user associated with a spreadsheet. The application service generates a prompt based on the user input and at least a portion of the spreadsheet. The prompt constrains the LLM service to a domain specific to the spreadsheet based on the portion. and submits the prompt to the LLM service. The application service receives a reply to the prompt from the LLM service and responds to the input based on the reply from the LLM service.

7-morpholino-l,6-naphthyridin-5-yl derivatives and pharmaceutical compositions thereof useful as dna-pk inhibitor

7-morpholino-1,6-naphthyridin-5-yl derivatives and pharmaceutical compositions thereof useful as dna-pk inhibitor

Prompt chaining for llm integrations in spreadsheet environments

Technology is disclosed herein for an application service which interfaces with an LLM service. In an implementation, the application service receives a natural language input from a user associated with a spreadsheet. The application service generates multiple prompts based on the natural language input and a portion of the spreadsheet and determines an order in which to input the prompts to an LLM service. The application service determines an order in which to input the prompts to an LLM service, then inputs the prompts to the LLM service according to the determined order.

Ostomy custom skin barrier method and system

Provided is a method 30 for producing a custom ostomy skin barrier 12, said method 30 comprising the steps of providing 32 a scanner 16 whereby a user is able to scan a torsal peristomal area 18, said scanner 16 configured to generate 34 a data image of the scanned peristomal area 18, and transmitting 36, by the scanner 16, the data image to a skin barrier production system 22. The method 30 also includes the step of analysing 38, by the production system 22, the received data image in order to produce 40 a skin barrier template whereby a custom ostomy skin barrier 12 corresponding with a stoma 20 in the scanned peristomal area 18 is producible.

Prompt chaining for llm integrations in spreadsheet environments

Technology is disclosed herein for an application service which interfaces with an LLM service. In an implementation, the application service receives a natural language input from a user associated with a spreadsheet. The application service generates multiple prompts based on the natural language input and a portion of the spreadsheet and determines an order in which to input the prompts to an LLM service. The application service determines an order in which to input the prompts to an LLM service, then inputs the prompts to the LLM service according to the determined order.

Llm integrations with spreadsheet environments

Technology is disclosed herein for an application service which interfaces with an LLM service. In an implementation, the application service receives a natural language input from a user associated with a spreadsheet. The application service generates a prompt based on the user input and at least a portion of the spreadsheet and submits the prompt to a large language model (LLM) service. The application service receives a reply to the prompt from the LLM service and responds to the input based on the reply from the LLM service.

Llm integrations with spreadsheet environments

Technology is disclosed herein for an application service which interfaces with an LLM service. In an implementation, the application service receives a natural language input from a user associated with a spreadsheet. The application service generates a prompt based on the user input and at least a portion of the spreadsheet and submits the prompt to a large language model (LLM) service. The application service receives a reply to the prompt from the LLM service and responds to the input based on the reply from the LLM service.

Prompt configuration for llm integrations in spreadsheet environments

Technology is disclosed herein for an application service which interfaces with an LLM service. In an implementation, the application service receives a natural language input from a user associated with a spreadsheet. The application service generates a prompt based on the user input and at least a portion of the spreadsheet. The prompt constrains the LLM service to a domain specific to the spreadsheet based on the portion. and submits the prompt to the LLM service. The application service receives a reply to the prompt from the LLM service and responds to the input based on the reply from the LLM service.

Lipids for use in lipid nanoparticle formulations

Compounds are provided having the following structure: (I) or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R3, L1, L2, G1, G2 and G3 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.

Lipids for use in lipid nanoparticle formulations

Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R 3 , L 1 , L 2 , G 1 , G 2 and G 3 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.

Systems and methods for wireless communication

Various aspects of the present disclosure generally relate to wireless communication. In some aspects, a method may include simulating a degradation of at least one of a first wireless communication link with a network or a different second wireless communication link with the network based on detecting that a first set of one or more packets, which were received via the first wireless communication link with the network and were added to a packet buffer, and a second set of one or more packets, which were received via the different second wireless communication link with the network and were added to the packet buffer, satisfy a threshold occupancy of the packet buffer. Numerous other aspects are provided.

Ergonomic gym grip

Fluorinated cationic lipids for use in lipid nanoparticles

Compounds are provided having the following structure: (I) or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R 3 , L 1 , L 2 , G 1 , G 2 and G 3 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.

Fluorinated cationic lipids for use in lipid nanoparticles

Compounds are provided having the following structure: (I) or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R2a, R2b, R3a, R3b, R7, R8, R9, L1, L2, G1, G2, G3, b, and c are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.

Medical virtual reality and mixed reality collaboration platform

Provided is a collaboration system (10) for collaborating on medical image data. The system (10) includes an input interface (12) into which a series of two-dimensional image data files in Digital Imaging and Communications in Medicine (DICOM) format are receivable, the series of image data files representing successive two dimensional scans of a body area. Also included is a data modelling processor (14) operable to receive the two-dimensional image data files from the input interface (12) and to compile the series of two-dimensional image data files to a three dimensional (3D) representation of the data. Further included is database (16) connected to the data modelling processor (14), on which any one, or both of the series of two-dimensional (2D) image data files and three dimensional (3D) representations of the data is stored, and output interface (18) for presenting any one, or both of the series of two-dimensional (2D) image data files and three dimensional (3D) representations of the data securely to a remote user using display devices (20).

Medical virtual reality and mixed reality collaboration platform