Method for reducing power consumption in bluetooth and CDMA modes of operation

Method for reducing power consumption in Bluetooth and CDMA modes of operation is disclosed. According to a disclosed embodiment, the time for a next scheduled CDMA wakeup process to be performed by a CDMA module is established. Thereafter, if the next CDMA wakeup process is scheduled to be performed before the next Bluetooth wakeup process, a Bluetooth wakeup process is synchronized to be performed by a Bluetooth module at the same time as the next CDMA wakeup process. Following, when the time arrives for the CDMA module to perform the next CDMA wakeup process, the Bluetooth module also performs the Bluetooth wakeup process.

SOCKET INTERCONNECTOR FOR HIGH PAD COUNT MEMORY CARDS

A memory card socket interconnector is disclosed including a pair of cavities configured to receive a pair of memory cards. The cavities include patterns of memory card interconnect pads. A second surface of the socket interconnector includes socket interconnect pads, distributed across the second surface of the socket interconnector, which are electrically coupled to the memory card interconnect pads. The memory card socket interconnector may further include an anisotropic elastomeric sheet provided between the memory card pads and the memory card interconnect pads in each cavity to enable good electrical contact between the memory card pads and the memory card interconnect pads. 1. A memory card socket interconnector configured to support one or more memory cards in a socket of a host device , the memory card socket interconnector comprising:a set of memory card interconnect pads on a first surface of the memory card socket interconnector, the set of memory card interconnect pads configured to mate with pads on the one or more memory cards;a set of socket interconnect pads on a second surface of the memory card socket interconnector opposite the first surface, the set of socket interconnect pads configured to mate with pins within the socket of the host device, wherein the set of socket interconnect pads are spaced from each other by a greater amount than at least some of the set of memory card interconnect pads on the first surface; anda redistribution layer between the first and second surfaces electrically redistributing the set of memory card interconnect pads to the set of socket interconnect pads.2. The memory card socket interconnector of claim 1 , wherein the memory card socket interconnector is configured to support a first memory card having a PCIe interface claim 1 , the set of memory card interconnect pads mirroring a configuration of the pads on the first memory card.3. The memory card socket interconnector of claim 2 , wherein the memory card socket ...

Outdoor lantern with hand-painted shade

Self Locking Pivot Mount for Machine Mounted Devices

An improved Mount for Machine Mounted Devices. The self locking pivot mount improves on the previous designs by incorporating an enclosed mechanism that implements a self locking position or multiple positions. The self locking position or multiple positions enables deterministic pivot mount position, thus enabling designed limits on cable strain and contact with other structures. It further securely positions the pivot mount in a defined position, eliminating accidental undesired changes in position. 1) Enclosed mechanism self locking pivot mount for devices used on machines comprising:a pivot shaft, said pivot shaft comprising a nominally cylindrical shape, one or multiple receptacles operable to engage one or multiple pins and provisions for connecting a structure or device along a portion of its length;one or multiple locking pins, said locking pin or multiple pins each comprising a shape, dimensions and material strength operable to engage one or multiple pivot shaft pin receptacles and restrain rotation of the pivot shaft when engaged;one or multiple springs, said spring or multiple springs comprising a spring force and length sufficient to hold the pivot shaft laterally against the locking pin or multiple pins, move the pivot shaft laterally so as to engage the locking pin or multiple pins with one or multiple pivot shaft receptacles when said pin or multiple pins and receptacle or multiple receptacles align and retain said engagement;a fixed mount, said fixed mount enclosing the self locking mechanism, said self locking mechanism comprised of a pivot shaft comprising one or multiple locking pin receptacles, one or multiple locking pins and one or multiple springs, said fixed mount structure comprising a housing for the pivot shaft, said pivot shaft housing comprising a non-restraining rotating and sliding fit for the pivot shaft, said fixed mount structure further comprising one or multiple spring cavities, said spring cavities comprising a shape and ...

Base for hand torch

Safety wire plier

A safety wire plier includes a pair of plier arms with each of the arms including a jaw end and a handle. The plier arms of the safety wire plier are pivotally connected to each other for movement in either an open or closed position. The safety wire plier also includes a sealed lock for releasably locking the safety wire plier in the closed position.

Measurement of autonomic function

The present invention is an article of manufacture and method for using same, comprising at least two sensors having a paired offset potential of below about +/−1.0 mV; and a data gathering device connected to the sensors capable of measuring the voltage difference between the sensors. The sensors preferably are AgCl coated Silver.

Male enteral coupling

Drive unit for automotive vehicle

A vehicle drive unit that provides improved power transfer to a differential input member of a differential assembly. The vehicle drive unit is configured with an interlock system that is configured to inhibit the supply of electrical power from a source of electrical power if certain predetermined conditions are not met.

Service system and method

A system for servicing a fluid system can employ a pressure-reducing source to perform the desired service. The fluid system can be an engine cooling system or other fluid system.

System and method of processing solid waste

A system and associated method of processing solid waste via a waste gasification process results in usable by-products. The method utilizes a rotary kiln heated to a temperature of at least 800° F. and a reduction chamber, heated to a temperature of at least 1800° F. The solid waste is slowly rotated in the kiln for six to eight hours. The solid material is passed through screens to separate the ash from other items. Gases are monitored and transported to the reduction chamber to generate power. The gases are then transported to at least one air pollution control unit to remove contaminants before being vented into the atmosphere.

Male enteral coupling

System and method of generating electricity

A system and associated method of processing solid waste via a waste gasification process resulting in usable by-products may be used to generate electricity. The method utilizes a rotary kiln heated to a temperature of at least 800° F., a reduction chamber, heated to a temperature of at least 1800° F. and a boiler downstream of the reduction chamber. Steam generated in the boiler powers a turbine which operates a generator for generating electricity. Dampers may be positioned to bypass the power generation system. Gases are monitored and transported from the reduction chamber to at least one air pollution control unit to remove contaminants before being vented into the atmosphere.

Leak detection lamp

A light source for examining sites in heating, ventilating, and air conditioning systems for leaks using a fluorescent dye is described. The light source can include a low voltage lamp or a low heat generating lamp.

Enteral adaptor couplings

An enteral adapter coupling for connecting non-ENFit threaded enteral equipment with ISO 80369-3 compliant and compatible enteral equipment. The adapter coupling includes a first end substantially corresponding to an ISO 80369-3 coupling format, a second end substantially conforming to a threaded enteral feeding coupling format, and an internal lumen extending through the coupling allowing fluid communication between the first end and the second end.

Enteral syringe

Detection lamp

A light source for testing sites using a fluorescent dye is described. The light source can include a low voltage lamp or a low heat generating lamp.

Enteral syringe

Fluid injection system

An apparatus for injecting a fluid into a closed pressurized system can be connected to a service port of the system. The fluid can be introduced into the system using the resting and operating pressures of the closed pressurized system. The system can be a climate control system.

Visual Characteristic-of-Interest Position Indicator for Machine Conveyable Material

A system that visually indicates the position of a characteristic-of-interest of a machine conveyable material. The visual indication comprising direct, indirect and combinations thereof. 1) A visual indirect characteristic-of-interest position indication system for machine conveyable material , comprising:one or more visual indicators;a structure operable to span the width of and position the visual indicators in proximity to the material, said visual indicators arranged across the structure so that one or more visual indicators are operable to correlate with the position of a characteristic-of-interest of the material;the visual indicators operable to indicate a characteristic-of-interest of the material position by illuminating, not illuminating and combinations thereof the visual indicator correlated with the characteristic-of-interest.2) A visual indirect characteristic-of-interest position indication system for machine conveyable material claim 1 , wherein the visual indicators comprise being normally off and illuminating or flashing when a characteristic-of-interest is detected at the indicator position.3) A visual indirect characteristic-of-interest position indication system for machine conveyable material in claim 1 , wherein the visual indicators comprise being normally illuminated and turning off or flashing when a characteristic-of-interest is detected at the indicator position.4) A visual indirect characteristic-of-interest position indication system for machine conveyable material in claim 1 , wherein the visual indicators comprise being one color when a characteristic-of-interest is not detected and changing to a different color when a characteristic-of-interest is detected at the indicator position.5) A visual indirect characteristic-of-interest position indication system for machine conveyable material in claim 1 , wherein the visual indicators comprise a different color claim 1 , colors claim 1 , flashing and combinations thereof to indicate an ...

ENERGY DISTRIBUTION AND MARKETING BACKOFFICE SYSTEM AND METHOD

A retail energy provider system comprising a market transaction manager, business rules and requirements processor, usage rater, customer analysis and quality control auditor, customer billing processor and collection manager, customer payment processor, third party sales and marketing application programming interface, customer acquisition and residual income interface, having a wholesale forecaster, interactive voice response system, intranet web services, internet web services and network based external customer service and executive management systems and financial services functions, all said functions and systems interacting with a robust SQL database engine for which the novel database schema is taught herein. 1. A method for providing energy services to an energy customer comprising the steps of:receiving a set of payment information related to an energy customer;receiving a set of sales information related to a sales agent;receiving a set of inbound transactions, related to a set of energy usage data for the energy customer;deriving a set of bill information, related to the set of energy usage data and the set of payment information;deriving a set of outbound transactions, related to the set of inbound transactions;sending the set of outbound transactions; and,deriving a set of commissions, based on the set of payment information, the set of bill information, the set of sales information and the set of energy usage data.2. The method of wherein the step of deriving a set of commissions further comprises:deriving a bill delinquency condition from the set of bill information, the set of payment information and the set of energy usage data.3. The method of further comprising the steps of:receiving a set of customer information from the energy customer; andsending a connect order, in an outbound transaction of the set of outbound transactions, based on the set of customer information.4. The method of further comprising the steps of:deriving a bill delinquency ...

Enteral syringe

Fluid addition apparatus

An apparatus for adding fluid to a closed system can be connected to a service port of the system. The fluid can be added to the system by actuating valves on the system and on the fluid supply. The apparatus facilitates clean addition of the fluid to the system. The system can be a climate control system.

Accessory attachment winder for installing, removing and storing a vehicle covering

An accessory attachment winding device with rolling and positioning capabilities for installing, removing and storing a tonneau cover or other vehicle covering is disclosed. The accessory system is provided with preferred features of integral-unitary construction or multiple base member construction with extending inter-fitting and sliding parts, so that the device can be adjusted in terms of position and dimension to connect and attach to complimentary coupling or connection portions of a tonneau, vehicle or other covering. In its method and function of operation the device houses and presents complimenting coupling members which can be adjusted in terms of their positional relationship as housed in a respective base member, or in terms of the extensible, sliding and positional features of the cooperating base members utilized in the method and device of the present invention.

Selection procedure for identifying transgenic cells, embryos, and plants without the use of antibiotics

Transgenic cells may be selected using temperature sensitive marker proteins. In this method, a population of host cells are transformed with a foreign DNA construct which includes at least one first nucleic acid coding sequence and a second nucleic acid sequence encoding a temperature sensitive marker protein, wherein each of the first and second nucleic acid coding sequences are operatively linked to gene expression control sequences. Suitable temperature sensitive marker proteins which may be used herein include heat shock proteins, heat shock transcription factors, cold regulated proteins (COR), or cold regulated protein transcription factors. Following transformation, the population of cells are cultured under temperature conditions wherein growth of non-transformed cells is suppressed or prevented while growth of cells transformed with the DNA construct is supported or promoted. Thus, survival and/or significant growth of a cell is an indication that the cell has been successfully ...

Vented connector for medical fluid vessels

A connector for medical fluid vessels includes a fluid-seal fitting such as a male plug defining a lumen and mating with a cooperating connector, a mechanical fastener such as a screw thread for mating with the cooperating connector, and an outer housing positioned around the plug to form an annular space. Optionally, a cap can be provided with a fluid-seal fitting such as a male plug for mating with the lumen of the connector. The connector includes one or more vent openings for drainage and air-drying of any residual fluid in the annular space when capped, as well as for breaking a vacuum to prevent fluid backflow and thus ensure more accurate dosing. In some embodiments, the vent openings are provided in the outer housing. And in some embodiments, the vent openings are provided in the cap.

Transfer lid

A transfer lid for a fluid container, having an attachment collar for removably attaching the transfer lid to the fluid container, and an inner collar arranged generally concentrically with and spaced inwardly from the attachment collar, the inner collar having a vent opening such as a vent slot extending therethrough.

Enteral syringe

Techniques for fine grained correction of count bias in massively parallel DNA sequencing

Techniques for automated determination or correction of count bias are based on nucleic acid base content on a finer grained scale than a bin of interest in a target sequence. The techniques include obtaining a target sequence with bins where relative abundances indicate a condition and raw counts Hj of reads, from a subject, which start at each locus j. A partition indicates a fine-grained window at a position relative to a current locus and multiple strata indicating different base contents. Each locus is attributed to one stratum k(j). An expected count of each stratum, E(k), is determined based on Hj for j belonging to the stratum and a number of loci in the target belonging to the stratum. A copy number of a bin is based on a sum of E(k(j)) in the bin. Output data indicates condition of the subject based at least partly on the copy number.

Accessory attachment winder for installing, removing and storing a vehicle covering

An accessory attachment winding device with rolling and positioning capabilities for installing, removing and storing a tonneau cover or other vehicle covering is disclosed. The accessory system is provided with preferred features of integral-unitary construction or multiple base member construction with extending inter-fitting and sliding parts, so that the device can be adjusted in terms of position and dimension to connect and attach to complimentary coupling or connection portions of a tonneau, vehicle or other covering. In its method and function of operation the device houses and presents complimenting coupling members which can be adjusted in terms of their positional relationship as housed in a respective base member, or in terms of the extensible, sliding and positional features of the cooperating base members utilized in the method and device of the present invention.

Fluid injection system

An apparatus for injecting a fluid into a closed pressurized system can be connected to a service port of the system. The fluid can be introduced into the system using the resting and operating pressures of the closed pressurized system. The system can be a climate control system.

Fluid system service apparatus and method

An apparatus and method of servicing fluid systems by draining, filling, or leak testing the fluid system can employ a pressure-reducing source to perform the desired service. The fluid system can be an engine cooling system or other fluid system.

Female enteral coupling

Tissue compression assemblies with biodegradable interlinks

Devices are used to modify a metabolic pathway of a digestive system by creating a pathway within the intestinal tract through an anastomosis between a proximal location within the intestinal tract and a distal location within the intestinal tract. A magnetic anastomosis compression device includes a first arm, a second arm, a resilient member, and a pair of magnets. The magnetic anastomosis compression device further includes a degradable retaining element. The retaining element temporarily holds the first arm and second arm in a wide configuration in opposition to the bias exerted by the resilient member. Upon the degradation of the retaining element, the resilient member causes the first arm and second arm to transition to a narrow configuration. The magnetic anastomosis compression device is configured to magnetically couple with another magnetic anastomosis compression device positioned within a different location within the intestinal tract.

Socket interconnector with compressible ball contacts for high pad count memory cards

A memory card socket interconnector is disclosed including a pair of cavities configured to receive a pair of memory cards. The cavities include patterns of memory card interconnect pads. A second surface of the socket interconnector includes socket interconnect pads, distributed across the second surface of the socket interconnector, which are electrically coupled to the memory card interconnect pads. The memory card socket interconnector may further include electrically conductive balls provided between the memory card pads and the memory card interconnect pads in each cavity to enable good electrical contact between the memory card pads and the memory card interconnect pads.

Measurement for Autonomic Function

The present invention is an article of manufacture and method for using same, comprising at least two self adhesive sensors having a paired offset potential of consistently below about +/−1.0 mV; and a data gathering device connected to the sensors capable of measuring the voltage difference between the sensors. The sensors preferably are AgCl coated Silver. 1. An article of manufacture , to quantify nociception and pain comprising:at least two self adhesive low offset sensors having an offset potential consistently below about +/−0.01 mV to measure a difference in electrical potential caused by an activation of a sympathetic nerve and an activation of a parasympathetic nerve, said sensors being selected to consistently have an offset potential below about +/−0.01 mV;said at least two self adhesive low offset sensors having a coating to conduct the difference in electrical potential caused by an activation of a sympathetic nerve and an activation of a parasympathetic nerve;and a data gathering device connected to the sensors capable of measuring a voltage difference between the electrodes.2. The article of claim 1 , wherein at least two of the sensors possess a sensing side having an AgCl coating on a Silver substrate3. The article of claim 1 , wherein the coating is a pre-applied conductive gel disposed on the sensing side of the sensors.4. The article of claim 1 , wherein the sensors are connected to a data gathering device via lead wires across a resistor of 0.5 to 500 k-Ohms.5. The article of claim 1 , wherein the sensors are 10 mm in diameter.6. The article of claim 1 , wherein the sensors are disposable.7. A device suitable for detecting a shift in the autonomic nervous system claim 1 , comprising:a first sensor, wherein said first sensor is utilized with at least one other sensor, and said first sensor having been selected to have an offset potential of consistently below about +/−0.01 mV when used with said other sensor for measuring a difference in ...

Method for reducing power consumption in a multi-mode device

Method for reducing power consumption in a multimode device is disclosed. The multimode device includes a COMM1 component and a COMM2 component. In one aspect, a COMM1 component may be a UWB component and a COMM2 component may be a CDMA component. According to a disclosed embodiment, the time for a next scheduled COMM1 wakeup process to be performed by a COMM1 module is established. Thereafter, if the next COMM1 wakeup process is scheduled to be performed before the next COMM2 wakeup process, a COMM2 wakeup process is synchronized to be performed by a COMM2 module at the same time as the next COMM1 wakeup process. Following, when the time arrives for the COMM1 module to perform the next COMM1 wakeup process, the COMM2 module also performs the COMM2 wakeup process.

System and method for marketing sponsored energy services

Systems and methods are disclosed for a retail energy marketing system including a server interacting with a remote display device, a sponsor, an energy market organization, and a set of financial services companies. The server executes an application for servicing customers while interacting with the remote display device and a sponsor application for sponsors to set up advertising and incentives for the retail energy marketing system. The server also executes a database, an ESI ID lookup application for validating customer eligibility for services and an accounting application for EMO energy usage transactions, EMO invoice transactions, customer bills, customer payments, treatment operations, customer incentives and sponsor commissions. A remote display device is placed at a retail location where customers can sign-up for energy services, view and print their billing and payment histories, and pay their bills. In return for using the remote display device, customers may receive incentives ...

Outdoor lantern having a hand-painted tinted shade

Combined frosted and clear seedy shade outdoor lantern

System and method for automatically determining crop characteristics using unmanned aerial vehicle (UAV)

A method and apparatus for automatically determining a characteristic of a crop using an unmanned aerial vehicle (UAV) includes operating the UAV at an elevation above a ground surface of a field and collecting first data that indicates an elevation of the UAV with a barometric pressure based altimeter of the UAV. Second data is collected with a SONAR sensor of the UAV that indicates a distance to a nearest object on the ground surface. The SONAR sensor has a SONAR sensor range and the elevation above the ground surface is less than the SONAR sensor range. The method further includes receiving the first data and the second data on a processor, and determining a height of the nearest object above the ground surface with the processor based on the first data and second data. Output data that indicates the height of the nearest object is presented on a display.

Light coupled detachable stern anchor and navigation light for boats

An apparatus and method that improves the usable life and reliability of detachable stern lights for boats. It replaces electrical energy coupling by light energy coupling, thereby eliminating electrical contact corrosion problems.

Energy distribution and marketing backoffice system and method

A retail energy provider system comprising a market transaction manager, business rules and requirements processor, usage rater, customer analysis and quality control auditor, customer billing processor and collection manager, customer payment processor, third party sales and marketing application programming interface, customer acquisition and residual income interface, having a wholesale forecaster, interactive voice response system, intranet web services, internet web services and network based external customer service and executive management systems and financial services functions, all said functions and systems interacting with a robust SQL database engine for which the novel database schema is taught herein.

Dosage forms having an inner core and an outer shell

An immediate release tablet is provided. The tablet comprises at least 60 weight % of an active ingredient and powdered wax having a melting point greater than about 90° C. The tablet may advantageously be produced by direct compression. Although the wax is hydrophobic, the tablet has excellent disintegration.

Flywheel operated tool

Disclosed and taught is a novel drive mechanism for a cyclic operating tool employing an energized flywheel to provide the necessary energy to perform a working cycle. The drive mechanism disclosed is particularly useful in hand tool applications such as a hand held nailing machine. The flywheel may be energized by a corded or battery powered motor. The herein disclosed mechanism teaches a novel pair of ball ramp cam plates wherein a first pair of ball ramps cause an initial engagement of a clutch with the energized flywheel whereupon rotation of the clutch causes activation of a second pair of ball ramps which affect compression of a spring which acts to increase the pressure applied to the clutch thereby assuring a slip free engagement between the clutch and he flywheel throughout the working cycle of the drive mechanism. Upon completion of the drive mechanisms working cycle, the second pair of ball ramp cam plates further act to disengage the clutch from the flywheel whereby the flywheel ...

Light coupled detachable bow navigation lights for boats

An apparatus that improves the usable life and reliability of detachable bow lights for boats. It replaces electrical energy coupling by light energy coupling, thereby eliminating electrical contact corrosion problems.

System and method for construction of internal controls for improved accuracy and sensitivity of DNA testing

Techniques for construction of internal controls for improved accuracy and sensitivity of DNA testing include obtaining first data and determining weights over real numbers for a normalization function in less than a day. The first data indicates a measured amount of reference sequences for nucleic acids from training samples. The reference sequences include a target, for which an abundance is indicative of a condition of interest, and covariates not correlated with the condition of interest. The normalization function involves a sum of abundances of the covariates, as internal controls, each multiplied by a corresponding one of the weights. The weights are determined based on minimizing variance of a Taylor expansion of a ratio of a measured amount of the target divided by a value of the normalization function evaluated with measured amounts of the covariates over a portion of the first data in which the condition is absent.

Brittle-coating, soft core dosage form

The present invention provides an oral dosage form for delivering active agents having a soft core with an active agent particles, which have an average size of greater than about 50 μm, and a brittle shell encasing the soft core, wherein the weight ratio of drug particles to shell being from about 1.0:0.5 to about 1.0:15.

Traceless flip chip assembly and method

A method for forming a fine-pitch flip chip assembly interconnects fine pitch devices after they have been connected to a carrier substrate. A die having a plurality of conductive sections, such as solder balls, is attached to a conductive layer of the substrate. An interconnect pattern is then formed in the conductive layer to connect the conductive sections and generate electronic functionality to the assembly. By forming the interconnect pattern after the device have been connected to the carrier, the invention provides precise alignment between the devices and the interconnect pattern without actually aligning the two components during the assembly process.

Energy distribution and marketing backoffice system and method

A retail energy provider system comprising a market transaction manager, business rules and requirements processor, usage rater, customer analysis and quality control auditor, customer billing processor and collection manager, customer payment processor, third party sales and marketing application programming interface, customer acquisition and residual income interface, having a wholesale forecaster, interactive voice response system, intranet web services, internet web services and network based external customer service and executive management systems and financial services functions, all said functions and systems interacting with a robust SQL database engine for which the novel database schema is taught herein.

Vented connector for medical fluid vessels and tapered plug

A connector for medical fluid vessels includes a fluid-seal fitting such as a male plug defining a lumen and mating with a cooperating connector, a mechanical fastener such as a screw thread for mating with the cooperating connector, and an outer housing positioned around the plug to form an annular space. A cap can be provided with a fluid-seal fitting such as a male plug for mating with the lumen of the connector. In example embodiments, the male plug is tapered and can comprise one or more projections for sealingly engaging with the lumen of the connector. According to some example embodiments, the cap can be tethered to the connector.

SOCKET INTERCONNECTOR WITH COMPRESSIBLE BALL CONTACTS FOR HIGH PAD COUNT MEMORY CARDS

A memory card socket interconnector is disclosed including a pair of cavities configured to receive a pair of memory cards. The cavities include patterns of memory card interconnect pads. A second surface of the socket interconnector includes socket interconnect pads, distributed across the second surface of the socket interconnector, which are electrically coupled to the memory card interconnect pads. The memory card socket interconnector may further include electrically conductive balls provided between the memory card pads and the memory card interconnect pads in each cavity to enable good electrical contact between the memory card pads and the memory card interconnect pads. 1. A memory card socket interconnector configured to support one or more memory cards in a socket of a host device , the memory card socket interconnector comprising:a set of memory card interconnect pads on a first surface of the memory card socket interconnector, the set of memory card interconnect pads configured to mate with pads on the one or more memory cards;an electrically conductive epoxy layer adhered to discrete ones of the interconnect pads, the electrically conductive epoxy layer facilitating electrical contact between the set of memory card interconnect pads and the pads on the one or more memory cards;a set of socket interconnect pads on a second surface of the memory card socket interconnector opposite the first surface, the set of socket interconnect pads configured to mate with pins within the socket of the host device, wherein a center-to-center distance of the set of socket interconnect pads are greater than a center-to-center distance of at least some of the set of memory card interconnect pads on the first surface; anda redistribution layer between the first and second surfaces electrically redistributing the set of memory card interconnect pads to the set of socket interconnect pads.2. The memory card socket interconnector of claim 1 , wherein:the memory card socket ...

Light Conduit Nautical Navigation light

A light conduit nautical navigation light with improved usable life and reliability. It replaces electrical energy coupling by light energy coupling, thereby eliminating electrical contact corrosion problems. It further offers a more robust light emitting structure due to its solid structure. 1) nautical navigation light system comprising:a base, said base comprising material suitable for nautical applications, a structure that provides coupling to or incorporation within a nautical navigation structure, mechanical coupling to the light conduit proximal end, and light coupling of the light source or sources to the light conduit proximal end;one or multiple light driver devices, each light driver device operable to connect to an electrical power source and one or multiple light sources, and comprising power conversion and control for one or multiple light sources;one or multiple light sources, each light source operable to connect to a light driver device or devices and operable to project light through the base light coupling and into the light conduit proximal end, and comprising electrical to light energy conversion;a light conduit, said light conduit structure comprising one bar or multiple adjacent bars, each bar comprising transparency, a higher refractive index than the ambient medium, a proximal end light coupling surface area and a middle portion whose combination of structure and material make it operable to efficiently conduit and confine the light to the distal end, said light conduit proximal end operable to couple with the base;and a reflective surface in proximity to the distal end of the light conduit bar or bar, said reflective surface comprising an angle-of-incidence to the conducted light operable to redirect and emit the light and a shape operable to emit light in the desired emission pattern.2) The base of claim 1 , wherein the mechanical coupling comprises a socket operable to receive the light conduit proximal end.3) The light driver device or ...

System and methods for customer relationship management for an energy provider

Systems and methods are disclosed for a customer relationship management system for a retail electric energy provider. A customer valuation engine is applied to evaluate customer data to make customer valuations, continuously or on-demand, in support of customer service through a call center. In a preferred embodiment, monthly average profitability is determined as one customer valuation and probability of attrition is determined as another customer valuation. A customer retention matrix and a customer treatment matrix are developed based constructing a graph of customer monthly average profitability and probability of attrition. The customer retention matrix provides a set of instructions to a call center operator to aid the operator in communicating with the customer while helping retain the customer. The customer treatment matrix provides a set of instructions to a call center operator to aid the operator in communicating with a customer about late bills, disconnects and other treatment ...

Solar antenna array fabrication

Methods for constructing multi-walled carbon nanotube (MWCNT) antenna arrays, may include: variable doping of the MWCNTs, forming light pipes with layers of variable dielectric glass, forming geometric diodes on full-wave rectified devices that propagate both electrons and holes, using clear conductive ground plans to form windows that can control a building's internal temperature, and generating multiple lithographic patterns with a single mask.

Synthetic herbicide resistance gene

The invention provides a DNA molecule, a DNA construct, a transgenic plant and a transgenic plant part comprising a synthetic DNA sequence. The synthetic DNA sequence encodes an enzyme that degrades 2,4-dichlorophenoxyacetic acid (2,4-D) to dichlorophenol. The synthetic DNA sequence comprises a natural microbial sequence that encodes the enzyme in which at least a plurality of the codons of the natural microbial sequence have been replaced by codons more preferred by a plant. The invention also provides a method of controlling weeds in a field containing transgenic plants according to the invention by applying an auxin herbicide, such as 2,4-D, to the field. The invention further provides methods of selecting plants and plant cells that have been transformed with a DNA construct according to the invention using an auxin herbicide.

SYSTEM AND METHOD FOR MARKETING SPONSORED ENERGY SERVICES

Systems and methods are disclosed for a retail energy marketing system including a server interacting with a remote display device, a sponsor, an energy market organization, and a set of financial services companies. The server executes an application for servicing customers while interacting with the remote display device and a sponsor application for sponsors to set up advertising and incentives for the retail energy marketing system. The server also executes a database, an ESI ID lookup application for validating customer eligibility for services and an accounting application for EMO energy usage transactions, EMO invoice transactions, customer bills, customer payments, treatment operations, customer incentives and sponsor commissions. A remote display device is placed at a retail location where customers can sign-up for energy services, view and print their billing and payment histories, and pay their bills. In return for using the remote display device, customers may receive incentives from the sponsor. 1. A system for sponsoring energy services from an energy provider at a remote display device comprising:a server;the remote display device, in communication with the server; receiving a set of sponsor information;', 'receiving a set of energy usage information related to an energy customer;', 'sending the set of sponsor information to the remote display device;', 'sending the energy usage information to the remote display device;', 'receiving a set of payment information from the remote display device; and,', 'deriving a sponsor commission from one or more of the group of the energy usage information, the payment information, and the set of sponsor information., 'the server causing the system to perform operations comprising2. The system of wherein the remote display device further comprises a kiosk and wherein the sponsor information includes an advertisement that is displayed on the kiosk.3. The system of wherein the remote display device further comprises a ...

Enteral syringe

SAFETY WIRE PLIER

A safety wire plier includes a pair of plier arms with each of the arms including a jaw end and a handle. The plier arms of the safety wire plier are pivotally connected to each other for movement in either an open or closed position. The safety wire plier also includes a sealed lock for releasably locking the safety wire plier in the closed position.

Lycianthes plant named ‘Variegated Splash’

A distinct cultivar of Lycianthes plant named ‘Variegated Splash’, characterized by its upright and spreading plant habit; unique green, pale yellow and ivory variegated foliage; attractive dark purple flowers; and good garden performance.

Socket interconnector for high pad count memory cards

A memory card socket interconnector is disclosed including a pair of cavities configured to receive a pair of memory cards. The cavities include patterns of memory card interconnect pads. A second surface of the socket interconnector includes socket interconnect pads, distributed across the second surface of the socket interconnector, which are electrically coupled to the memory card interconnect pads. The memory card socket interconnector may further include an anisotropic elastomeric sheet provided between the memory card pads and the memory card interconnect pads in each cavity to enable good electrical contact between the memory card pads and the memory card interconnect pads.

Method for reducing power consumption in Bluetooth and CDMA modes of operation

Method for reducing power consumption in Bluetooth and CDMA modes of operation is disclosed. According to a disclosed embodiment, the time for a next scheduled CDMA wakeup process to be performed by a CDMA module is established. Thereafter, if the next CDMA wakeup process is scheduled to be performed before the next Bluetooth wakeup process, a Bluetooth wakeup process is synchronized to be performed by a Bluetooth module at the same time as the next CDMA wakeup process. Following, when the time arrives for the CDMA module to perform the next CDMA wakeup process, the Bluetooth module also performs the Bluetooth wakeup process.

Vented connector for medical fluid vessels

A connector for medical fluid vessels includes a fluid-seal fitting such as a male plug defining a lumen and mating with a cooperating connector, a mechanical fastener such as a screw thread for mating with the cooperating connector, and an outer housing positioned around the plug to form an annular space. Optionally, a cap can be provided with a fluid-seal fitting such as a male plug for mating with the lumen of the connector. The connector includes one or more vent openings for drainage and air-drying of any residual fluid in the annular space when capped, as well as for breaking a vacuum to prevent fluid backflow and thus ensure more accurate dosing. In some embodiments, the vent openings are provided in the outer housing. And in some embodiments, the vent openings are provided in the cap.

IMPLANTABLE APPARATUS FOR MODULATION OF SKELETAL GROWTH

An implantable apparatus for use in the correction of skeletal deformities comprising a hinge applied in various orientations across one or more growth plates and attached to bone via attachment members. 1. An implantable skeletal growth deformity correction device , the device comprising:a hinged element including a hinge which lies on a hinge axis; andengagement means disposed to either side of the hinge axis of the hinged element and adapted to engage with a skeletal structure on either side of a growth plate and position the device with respect to the skeletal structure;wherein the hinge lying on the hinge axis is adapted to generate relative rotational motion between the engagement means disposed to either side of the hinge axis through two orthogonal planes upon opening and closing of the hinge about the hinge axis; andwherein the hinge axis lies in a first plane that, in use with the device implanted in the body of a patient, is perpendicular to a plane of the growth plate, and wherein in the first plane the hinge axis lies on a second plane, the second plane lying at an angle of more than 0 degrees and less than 90 degrees with respect to the plane of the growth plate.2. An implantable skeletal growth deformity correction device as claimed in claim 1 , wherein an element of the engagement means disposed to one side of the hinged element comprises an attachment member adapted to attach to a skeletal structure.3. An implantable skeletal growth deformity correction device as claimed in claim 2 , wherein the engagement means disposed to either side of the hinged element each comprise an attachment member adapted to attach to a skeletal structure.4. An implantable skeletal growth deformity correction device as claimed in claim 1 , wherein claim 1 , in use the extent of opening of the hinged element changes in response to movement of the skeletal structures on either side of the hinged element to which the device is attached.5. An implantable skeletal growth ...

Method for reducing power consumption in bluetooth and CDMA modes of operation

Techniques are provided for synchronizing a wakeup schedule for a first module and a wakeup schedule for a CDMA module in a wireless mobile unit operable in a synchronous communication system. In one embodiment, a next CDMA wakeup time is determined. A new wakeup time for the first module can then be synchronized to a next CDMA wakeup time when a next CDMA wakeup time is earlier than a next wakeup time for the first module ...

Fluid addition apparatus

An apparatus for adding fluid to a closed system can be connected to a service port of the system. The fluid can be added to the system by actuating valves on the system and on the fluid supply. The apparatus facilitates clean addition of the fluid to the system. The system can be a climate control system.

Syringe tip cap

IMPLANTABLE APPARATUS FOR MODULATION OF SKELETAL GROWTH

An implantable apparatus for use in the correction of skeletal deformities comprising a hinge applied in various orientations across one or more growth plates and attached to bone via attachment members.

Light coupled detachable bow navigation lights for boats

An apparatus that improves the usable life and reliability of detachable bow lights for boats. It replaces electrical energy coupling by light energy coupling, thereby eliminating electrical contact corrosion problems.

Hand torch

Service system and method

A system for servicing a fluid system can employ a pressure-reducing source to perform the desired service. The fluid system can be an engine cooling system or other fluid system.

Transportation and installation assist device for at least one pre-cast concrete tilt panel

A transportation and installation assist device (16) for at least one pre-cast concrete tilt panel (18). The panel(s) (18) are generally rectangular and have a first shorter end (44) with at least one lifting anchor therein, a second opposed shorter end (48) and a longitudinal axis (50) therebetween. The device (16) includes at least one frame (20) adapted to releasably engage an associated one of said panel(s) (18) substantially adjacent the second end (48) and support the panel (18) in a loading/transport orientation with the face of the associated panel (18) substantially vertical and said axis(es) (50) substantially horizontal. The frame (20) is also adapted for pivotal mounting to a table bed (14) of a truck (10) or trailer (12). The frame (20) and associated panel (18) pivot together when the first panel end (44) is lifted above the second panel end (48) until the associated panel (18) is in a releasing orientation with the face of the panel (18) substantially vertical and said axis ...

Syringe-to-syringe coupler

Light source provided with a housing enclosing voltage regulator means and method of manufacturing thereof

A light source for testing sites using a fluorescent dye is described. The light source can include a low voltage lamp or a low heat generating lamp.

Ultrasonic needle

The invention provides an ultrasonic needle. The ultrasonic needle comprises a needle, an outer tube and a handle, wherein the needle is internally arranged in the outer tube, the proximal end of the needle is connected with a needle core connector, a guide pipe fixing member and a needle adjusting pipe which are connected with each other are sequentially arranged on the needle core connector towards the distal end side, a proximal end locking member and a needle withdraw adjusting handle which are connected with each other sleeve the needle adjusting pipe, the needle withdraw adjusting handle is movably connected with a needle withdraw adjusting lock, the needle withdraw adjusting lock is provided with a guiding cavity with snapping grooves, the guiding cavity is embedded in the needle withdraw adjusting handle, the snapping grooves comprise an axial guiding groove and a locking groove in the radial direction of the distal end of the guiding groove, a snapping pin adapted to the snapping ...

TISSUE COMPRESSION ASSEMBLIES WITH BIODEGRADABLE INTERLINKS

Devices are used to modify a metabolic pathway of a digestive system by creating a pathway within the intestinal tract through an anastomosis between a proximal location within the intestinal tract and a distal location within the intestinal tract. A magnetic anastomosis compression device includes a first arm, a second arm, a resilient member, and a pair of magnets. The magnetic anastomosis compression device further includes a degradable retaining element. The retaining element temporarily holds the first arm and second arm in a wide configuration in opposition to the bias exerted by the resilient member. Upon the degradation of the retaining element, the resilient member causes the first arm and second arm to transition to a narrow configuration. The magnetic anastomosis compression device is configured to magnetically couple with another magnetic anastomosis compression device positioned within a different location within the intestinal tract. 1. A magnetic anastomosis compression assembly , comprising: (i) a first arm,', '(ii) a second arm, wherein the first arm and the second arm of the first compression device are pivotably attached to each other at a pair of joints, wherein each joint of the pair of joints of the first compression device include a magnet, and', '(iii) a resilient member, wherein the resilient member of the first compression device is attached to the first arm and the second arm of the first compression device, wherein the resilient member of the first compression device is configured to bias the first arm and the second arm of the first compression device toward a collapsed configuration; and, '(a) a first compression device, comprising (i) a first arm,', '(ii) a second arm, wherein the first arm and the second arm of the second compression device are pivotably attached to each other at a pair of joints, wherein each joint of the pair of joints of the second compression device include a magnet, and', '(iii) a resilient member, wherein the ...

Tissue compression assemblies with biodegradable interlinks

Devices are used to modify a metabolic pathway of a digestive system by creating a pathway within the intestinal tract through an anastomosis between a proximal location within the intestinal tract and a distal location within the intestinal tract. A magnetic anastomosis compression device includes a first arm, a second arm, a resilient member, and a pair of magnets. The magnetic anastomosis compression device further includes a degradable retaining element. The retaining element temporarily holds the first arm and second arm in a wide configuration in opposition to the bias exerted by the resilient member. Upon the degradation of the retaining element, the resilient member causes the first arm and second arm to transition to a narrow configuration. The magnetic anastomosis compression device is configured to magnetically couple with another magnetic anastomosis compression device positioned within a different location within the intestinal tract.

SOCKETS FOR REMOVABLE DATA STORAGE DEVICES

A socket includes a housing configured to receive a removable Data Storage Device (DSD) and a Thermal Interface Material (TIM). An assembly of the socket is attached to the housing and configured to expand due to heat. In a thermally expanded state, the assembly causes the TIM to come into contact with the removable DSD to draw heat away from the removable DSD. According to another aspect, a retaining strip or assembly is attached to a housing in a configuration such that the retaining strip or assembly expands due to heat to increase a resistance to removal of the removable DSD from the housing when the retaining strip or assembly is in a thermally expanded state. 1. A socket , comprising:a housing configured to receive a removable Data Storage Device (DSD);a Thermal Interface Material (TIM); andan assembly attached to the housing and configured to expand due to heat, wherein the assembly in a thermally expanded state causes the TIM to come into contact with the removable DSD to draw heat away from the removable DSD.2. The socket of claim 1 , wherein the assembly is further configured to push the TIM to come into contact with the removable DSD.3. The socket of claim 1 , wherein the assembly is further configured to push a first side of the removable DSD to cause a second side of the removable DSD opposite the first side to come into contact with the TIM.4. The socket of claim 1 , wherein the housing includes a slot portion through which the assembly is attached to the socket.5. The socket of claim 1 , wherein the assembly includes a bi-metal material composition.6. The socket of claim 1 , wherein the removable DSD is a Secure Digital (SD) memory card.7. The socket of claim 1 , wherein the location of the TIM relative to the housing when the removable DSD is fully received in the housing corresponds to at least one of a portion of the removable DSD with a higher thermal conductivity than other portions of the removable DSD and a portion of the removable DSD that ...

Anisotropic bonding system and method using dynamic feedback

An improved anisotropic bonding system and method connects two conductive surfaces together using an anisotropic material having elastic conductive particles dispersed in an insulating, heat-curable carrier. The system monitors bond resistance in real-time during the bonding process and controls the application of pressure to the bond based on a feedback signal corresponding to the bond resistance. When the bond resistance reaches a predetermined value, the applied pressure is reduced to a holding/clamping level to prevent over-compression as the curing schedule completes curing of the insulating carrier. By monitoring and responding to the bond resistance in real time during the bond compression process, the system prevents bond resistance increases caused by over-compression and conductor damage.

Method For Reducing Power Consumption In Bluetooth And CDMA Modes of Operation

Techniques are provided for synchronizing a wakeup schedule for a first module and a wakeup schedule for a CDMA module in a wireless mobile unit operable in a synchronous communication system. In one embodiment, a next CDMA wakeup time is determined. A new wakeup time for the first module can then be synchronized to a next CDMA wakeup time when a next CDMA wakeup time is earlier than a next wakeup time for the first module ...

Flywheel operated nailer

Disclosed and taught is a novel drive mechanism for a cyclic operating tool employing an energized flywheel to provide the necessary energy to perform a working cycle. The drive mechanism disclosed is particularly useful in hand tool applications such as a hand held nailing machine. The flywheel may be energized by a corded or battery powered motor. The herein disclosed mechanism teaches a novel pair of ball ramp cam plates wherein a first pair of ball ramps cause an initial engagement of a clutch with the energized flywheel whereupon rotation of the clutch causes activation of a second pair of ball ramps which affect compression of a spring which acts to increase the pressure applied to the clutch thereby assuring a slip free engagement between the clutch and he flywheel throughout the working cycle of the drive mechanism. Upon completion of the drive mechanisms working cycle, the second pair of ball ramp cam plates further act to disengage the clutch from the flywheel whereby the flywheel ...

Female enteral coupling

Automated personalized Zasshi

Devices, systems, and methods are provided for automated personalized Zasshi. The system may generate a computer-executable file including first content associated with a first book, and second content associated with a second book, the first content including first image data and first text data, and the second content including second image data and second text data. The system may determine a selectable action associated with the first content or the second content, and may determine metadata associated with the first content, the second content, and the selectable action. The system may transmit the computer-executable file and may receive selection data associated with the selectable action. The system may determine, based on the metadata, that the selectable action is associated with the first content. The system may determine, based on the selectable action, third content.

Measurement for autonomic function

The present invention is an article of manufacture and method for using same, comprising at least two self adhesive sensors having a paired offset potential of consistently below about +/-1.0 mV; and a data gathering device connected to the sensors capable of measuring the voltage difference between the sensors. The sensors preferably are AgCl coated Silver.

Sockets for removable data storage devices

A socket includes a housing configured to receive a removable Data Storage Device (DSD) and a Thermal Interface Material (TIM). An assembly of the socket is attached to the housing and configured to expand due to heat. In a thermally expanded state, the assembly causes the TIM to come into contact with the removable DSD to draw heat away from the removable DSD. According to another aspect, a retaining strip or assembly is attached to a housing in a configuration such that the retaining strip or assembly expands due to heat to increase a resistance to removal of the removable DSD from the housing when the retaining strip or assembly is in a thermally expanded state.

Detection lamp

A light source for testing sites using a fluorescent dye is described. The light source can include a low voltage lamp or a low heat generating lamp.

Outdoor lantern with seedy glass

Drug delivery pump

Light conduit nautical navigation light

A light conduit nautical navigation light with improved usable life and reliability. It replaces electrical energy coupling by light energy coupling, thereby eliminating electrical contact corrosion problems. It further offers a more robust light emitting structure due to its solid structure.

Method and apparatus for removing fluid from a fluid system

A method and apparatus for removing fluid from a fluid system. The method or apparatus can include a pressure-reducing source to facilitate fluid removal. The system can be an engine cooling system or other fluid system.

TISSUE COMPRESSION ASSEMBLIES WITH BIODEGRADABLE INTERLINKS

Devices are used to modify a metabolic pathway of a digestive system by creating a pathway within the intestinal tract through an anastomosis between a proximal location within the intestinal tract and a distal location within the intestinal tract. A magnetic anastomosis compression device includes a first arm, a second arm, a resilient member, and a pair of magnets. The magnetic anastomosis compression device further includes a degradable retaining element. The retaining element temporarily holds the first arm and second arm in a wide configuration in opposition to the bias exerted by the resilient member. Upon the degradation of the retaining element, the resilient member causes the first arm and second arm to transition to a narrow configuration. The magnetic anastomosis compression device is configured to magnetically couple with another magnetic anastomosis compression device positioned within a different location within the intestinal tract. 120-. (canceled)21. A magnetic anastomosis compression assembly , comprising:(a) a first compression device; and (i) a first arm,', '(ii) a second arm, wherein the first and second arms are configured to bias the respective first or second compression device toward a collapsed configuration,', '(iii) first and second joints that pivotably connect the first arm with the second arm along a single pivot axis at each of the joints, wherein each joint includes a magnet, and', '(iv) a retaining member, wherein the retaining member is configured to couple the first joint with the second joint and overcome the bias of the first and second arms to thereby retain the respective first or second compression device in an expanded configuration., '(b) a second compression device configured to magnetically couple with the first compression device, wherein each of the first compression device and the second compression device comprises22. The anastomosis compression assembly of claim 21 , wherein the retaining member of each compression ...

Service system and method

A system for servicing a fluid system can employ a pressure-reducing source to perform the desired service. The fluid system can be an engine cooling system or other fluid system.

Light conduit underwater illumination system

An apparatus that provides underwater illumination by conducting light from a light source through a light conduit, said light emanating from the distal end of the light conduit into water. 1) A light conduit underwater illumination system , comprising:a light source, said light source comprising one or more light emitting devices;a light conduit or multiple coupled light conduits, each said light conduit comprising one or multiple light confining and conducting bars, said light conduit or multiple coupled light conduits comprising a proximal end operable to receive the light source light, a middle portion that conducts and confines said light within itself, and a distal end operable for said light to emerge into the underwater environment, said light conduit or multiple coupled light conduits operable to be at least partially submerged;a base, said base comprising housing or attachment of the light source, coupling of the proximal end of light conduit or multiple coupled light conduits and able to be located above the water surface, at the water surface, below the water surface and combinations thereof.2) A light conduit underwater illumination system in claim 1 , wherein the light source comprises a Light Emitting Diode (LED) or multiple LEDs.3) A light conduit underwater illumination system in claim 1 , wherein the light conduit comprises a bar or multiple bars claim 1 , said bar shape comprising claim 1 , but not limited to claim 1 , half-round claim 1 , round claim 1 , triangular claim 1 , ellipse claim 1 , rectangular and combinations thereof.4) A light conduit underwater illumination system in claim 1 , wherein the light conduit bar material comprises acrylic claim 1 , polycarbonate claim 1 , glass and combinations thereof.5) A light conduit underwater illumination system in claim 1 , wherein the light conduit or multiple coupled light conduits longitudinal shape is comprised of linear claim 1 , nonlinear and combinations thereof.6) A light conduit underwater ...

Low average velocity pedestrial motion identification

Systems and methods for identifying a motion state of a mobile device are disclosed. In one embodiment, identifying a motion state of a mobile device using acceleration signals from one or more accelerometers comprises: detecting any pedestrial steps associated with a user of the mobile device during an observation period based on the acceleration signals; determining a maximum number of consecutive pedestrial steps taken during the observation period from the detected pedestrial steps; and declaring a high average velocity motion state or a low average velocity motion state for the observation period based on the determined maximum number of consecutive pedestrial steps.

Remote entry system

A system is disclosed for providing secure access to a controlled item, the system comprising a database of biometric signatures, a transmitter subsystem comprising a biometric sensor for receiving a biometric signal, means for matching the biometric signal against members of the database of biometric signatures to thereby output an accessibility attribute, and means for emitting a secure access signal conveying information dependent upon said accessibility attribute, wherein the secure access signal comprises one of at least a rolling code, an encrypted Bluetooth™ protocol, and a WiFi™ protocol, and a receiver sub-system comprising means for receiving the transmitted secure access signal and means for providing conditional access to the controlled item dependent upon said information.

Systems And Methods For Detecting Airway Occlusion

In one embodiment, airway occlusion detection is performed by applying ultrasonic pulses into the neck of a patient, receiving the ultrasonic pulses after they have passed through the neck, and analyzing the pulses to determine whether or not an airway of the patient is partially or fully occluded.

Vented Connector for Medical Fluid Vessels

A connector for medical fluid vessels includes a fluid-seal fitting such as a male plug defining a lumen and mating with a cooperating connector, a mechanical fastener such as a screw thread for mating with the cooperating connector, and an outer housing positioned around the plug to form an annular space. Optionally, a cap can be provided with a fluid-seal fitting such as a male plug for mating with the lumen of the connector. The connector includes one or more vent openings for drainage and air-drying of any residual fluid in the annular space when capped, as well as for breaking a vacuum to prevent fluid backflow and thus ensure more accurate dosing. In some embodiments, the vent openings are provided in the outer housing. And in some embodiments, the vent openings are provided in the cap. 1. (canceled)2. (canceled)3. (canceled)4. (canceled)5. (canceled)6. (canceled)7. (canceled)8. A male enteral feeding connector , comprising:a first connector portion configured for connecting to a female enteral feeding connector;a tube engagement portion integral with and opposite the first connector portion and configured for connecting to an enteral feeding tube for delivering enteral feeding fluid to a patient;a liquid passage extending along an axis through the first connector portion and the tube engagement portion, the first connector portion including a continuous outer surface for sealing engagement with the female enteral feeding connector;an annular portion integral with and surrounding the first connector portion, the annular portion comprising a threaded inner surface; anda connecting portion connecting the first connector portion to the annular portion, the connecting portion being discontinuous permitting liquid to pass through the connecting portion so that liquid is prevented from pooling between the first connector portion and the annular portion, wherein the connecting portion is defined by spaced apart connecting supports extending between the first ...

ENTERAL ADAPTOR COUPLINGS

An enteral adapter coupling for connecting non-ENFit threaded enteral equipment with ISO 80369-3 compliant and compatible enteral equipment. The adapter coupling includes a first end substantially corresponding to an ISO 80369-3 coupling format, a second end substantially conforming to a threaded enteral feeding coupling format, and an internal lumen extending through the coupling allowing fluid communication between the first end and the second end. 1. An enteral adapter coupling comprising a first end substantially corresponding to an ISO 80369-3 compliant coupling format , a second end substantially conforming to a threaded enteral feeding coupling format , and an internal lumen extending through the coupling allowing fluid communication between the first end and the second end.2. The enteral adapter coupling of claim 1 , wherein the first end comprises a male ISO 80369-3 compliant tip having a tapered lead-in portion claim 1 , surrounded by a coaxial connection collar having an internally threaded annular surface.3. The enteral adapter coupling of claim 1 , wherein the second end comprises a threaded surface defining a thread pitch of between about 2 mm to about 3 mm.4. The enteral adaptor coupling of claim 3 , wherein the thread pitch is about 2.450 mm.5. The enteral adapter coupling of claim 1 , wherein the second end comprises a threaded tip geometry having an outer tip diameter of between about 5 mm to about 8 mm.6. The enteral adaptor coupling of claim 5 , wherein the outer tip diameter is about 6.675 mm.7. The enteral adapter coupling of claim 1 , wherein the second end comprises a tip geometry having a tip length of between 8 mm to 11 mm.8. The enteral adaptor of claim 7 , wherein the tip length is about 9.667 mm9. The enteral adaptor coupling of claim 1 , wherein the first end comprises a female ISO 80369-3 compliant tip having at least a pair of helically inclined ribs extending radially from the external face of the tip.10. The enteral adaptor coupling ...

SYSTEMS AND METHODS FOR DETERMINING PATTERN OF INHERITANCE IN EMBRYOS

A method for determining pattern of inheritance in an embryo for a region of interest is provided, comprising receiving embryo, maternal and paternal sequence data; aligning the received sequence data to a reference genome; identifying a region of interest in the aligned embryo sequence data; identifying single nucleotide polymorphisms (SNPs) in the maternal sequence data, paternal sequence data, and the identified region of interest in the embryo sequence data; imputing missing gaps in the maternal sequence data and the paternal sequence data using an imputation reference; counting the number of SNPs that are common between the embryo and the mother/father in the identified region of interest for the embryo sequence data and a corresponding region on the maternal/paternal sequence data to determine a maternal/paternal contribution value; and classifying a pattern of inheritance for the embryo as maternal or paternal based on the relative contribution values between mother and father. 1. A method for determining pattern of inheritance in an embryo for a region of interest , comprising:receiving embryo, maternal and paternal sequence data, wherein the maternal sequence data is from a mother of the embryo and the paternal sequence data is from a father of the embryo;aligning the received sequence data to a reference genome;identifying a region of interest in the aligned embryo sequence data;identifying single nucleotide polymorphisms (SNPs) in the maternal sequence data, paternal sequence data, and the identified region of interest in the embryo sequence data;imputing missing gaps in the maternal sequence data and the paternal sequence data using an imputation reference;counting the number of SNPs that are common between the embryo and the mother in the identified region of interest for the embryo sequence data and a corresponding region on the maternal sequence data to determine a maternal contribution value;counting the number of SNPs that are common between the ...

Resolving genome fractions using polymorphism counts

Methods of reliably estimating genomic fraction (e.g., fetal fraction) from polymorphisms such as small base variations or insertions-deletions are disclosed. Sequenced data from a multigenomic source is used to determine allele counts for one or more of the polymorphisms. For one or more of the polymorphisms, zygosity is assigned, and genomic fraction is determined from the zygosity and allele counts. Certain embodiments employ SNPs as the relevant polymorphism. The disclosed methods can be applied as part of an intentional, pre-designed re-sequencing study targeted against known polymorphisms or can be used in a retrospective analysis of variations found by coincidence in overlapping sequences generated from maternal plasma (or any other setting where a mixture of DNA from several people are present).

TRANSFER LID

A transfer lid for a fluid container, having an attachment collar for removably attaching the transfer lid to the fluid container, and an inner collar arranged generally concentrically with and spaced inwardly from the attachment collar, the inner collar having a vent opening such as a vent slot extending therethrough. 1. A transfer lid for a fluid container , the transfer lid comprising:an attachment collar for removably attaching the transfer lid to the fluid container; andan inner collar arranged generally concentrically with and spaced inwardly from the attachment collar, the inner collar comprising a vent opening extending therethrough.2. The transfer lid of claim 1 , wherein the vent opening comprises a vent slot.3. The transfer lid of claim 1 , wherein the vent opening extends generally radially through the inner collar.4. The transfer lid of claim 1 , wherein the vent opening extends non-radially through the inner collar.5. The transfer lid of claim 4 , wherein the non-radial vent opening comprises an active vent allowing a user to selectively open and close the vent opening.6. The transfer lid of claim 1 , wherein the inner collar comprises a tapered contact face for engagement with the fluid container.7. The transfer lid of claim 1 , wherein the fluid container comprises a breast milk pump collection container having an externally threaded rim claim 1 , and wherein the attachment collar of the transfer lid comprises internal threads compatible with the externally threaded rim of the breast milk pump collection container.8. The transfer lid of claim 1 , further comprising a fluid transfer port for transferring fluid through the transfer lid to and from the fluid container.9. The transfer lid of claim 8 , wherein the fluid transfer port comprises an enteral-only coupling.10. The transfer lid of claim 9 , wherein the enteral-only coupling is compatible with ENFit design standard (ISO 80369-3).11. The transfer lid of claim 8 , further comprising a port closure ...

VENTED CONNECTOR FOR MEDICAL FLUID VESSELS

A connector for medical fluid vessels includes a fluid-seal fitting such as a male plug defining a lumen and mating with a cooperating connector, a mechanical fastener such as a screw thread for mating with the cooperating connector, and an outer housing positioned around the plug to form an annular space. Optionally, a cap can be provided with a fluid-seal fitting such as a male plug for mating with the lumen of the connector. The connector includes one or more vent openings for drainage and air-drying of any residual fluid in the annular space when capped, as well as for breaking a vacuum to prevent fluid backflow and thus ensure more accurate dosing. In some embodiments, the vent openings are provided in the outer housing. And in some embodiments, the vent openings are provided in the cap. 1. A connector for connection to a fluid vessel and a cooperating connector , the connector comprising:a first end from which the vessel extends, a second end, and a lumen extending therethrough from the first end to the second end;a fluid-seal fitting that at least partially defines the lumen and sealingly mates with the cooperating connector to provide conveyance of the fluid; andan outer housing positioned around the fluid-seal fitting to form an annular space therebetween with an access opening at the second end of the connector, the outer housing including one or more vent openings extending between the annular space and external to the annular space when the access opening of the annular space is capped, wherein the one or more outer-housing vent openings allow for drainage and air-drying of any residual amount of the fluid in the annular space.2. The connector of claim 1 , wherein the outer housing includes a peripheral sidewall and an endwall that cooperate with the fluid-seal fitting to define the annular space claim 1 , and wherein the one or more outer-housing vent openings include at least one vent opening formed in the outer-housing sidewall.3. The connector of ...

Techniques for fine grained correction of count bias in massively parallel DNA sequencing

Techniques for automated determination or correction of count bias are based on nucleic acid base content on a finer grained scale than a bin of interest in a target sequence. The techniques include obtaining a target sequence with bins where relative abundances indicate a condition and raw counts Hj of reads, from a subject, which start at each locus j. A partition indicates a fine-grained window at a position relative to a current locus and multiple strata indicating different base contents. Each locus is attributed to one stratum k(j). An expected count of each stratum, E(k), is determined based on Hj for j belonging to the stratum and a number of loci in the target belonging to the stratum. A copy number of a bin is based on a sum of E(k(j)) in the bin. Output data indicates condition of the subject based at least partly on the copy number. 1. A method executed on a processor comprising:a. obtaining first data that indicates a target sequence of nucleic acid bases at a plurality of loci, wherein the target sequence comprises a plurality of bins of loci for which a relative abundance is indicative of a condition of interest;b. obtaining second data that indicates alignment with the target sequence of reads of DNA fragments in a sample from a subject;c. determining a raw count Hj of reads that start at each locus j;d. obtaining partition data that indicates, for a first partition, a window comprising a number of bases less than a number of loci in a bin and position relative to a current locus, and a plurality of strata based on a corresponding plurality of different contents of nucleic acid bases in the window;e. attributing to each locus j in the target sequence a stratum k(j) of the plurality of strata of the first partition based on the content of nucleic acid bases in the target sequence in the window relative to the locus j;f. determining an expected count of each stratum, E(k), in the first partition based on the raw counts Hj of each locus j belonging to ...

Set membership testers for aligning nucleic acid samples

Disclosed are methods and tools for rapidly aligning reads to a reference sequence. These methods and tools employ Bloom filters or similar set membership testers to perform the alignment. The reads may be short sequences of nucleic acids or other biological molecules and the reference sequences may be sequences of genomes, chromosomes, etc. The Bloom filters include a collection of hash functions, a bit array, and associated logic for applying reads to the filter. Each filter, and there may be multiple of these used in a particular application, is used to determine whether an applied read is present in a reference sequence. Each Bloom filter is associated with a single reference sequence such as the sequence of a particular chromosome. In one example, chromosomal abundance is determined by aligning reads from a sequencer to multiple chromosomes, each having an associated Bloom filter or other set membership tester.

SYSTEMS AND METHODS FOR AUTONOMOUS MACHINE INTERPRETATION OF HIGH THROUGHPUT BIOLOGICAL ASSAYS FOR EMBRYO SELECTION

A method for identifying chromosomal abnormalities in an embryo, is disclosed. Sample genomic sequence information obtained from an embryo is received, wherein the sample genomic sequence information is comprised of a plurality of genomic sequence reads. The sample genomic sequence information is aligned against a reference genome. The sample genomic sequence information is normalized against baseline genomic sequence information to correct the sample genomic sequence information for locus effects and generate a normalized sample genomic sequence information dataset. One or more correction factors derived from a regression analysis of error factors is applied to the normalized sample genomic sequence information dataset to correct for technical effects and generate de-noised sample genomic sequence information dataset. Copy number variations in the de-noised sample genomic sequence information dataset is identified when a frequency of genomic sequence reads aligned to a chromosomal position on the reference genome deviates from a frequency threshold. 1. A method for identifying chromosomal abnormalities in an embryo , comprising:receiving sample genomic sequence information obtained from an embryo, wherein the sample genomic sequence information is comprised of a plurality of genomic sequence reads;aligning the sample genomic sequence information against a reference genome;normalizing the sample genomic sequence information against baseline genomic sequence information to correct the sample genomic sequence information for locus effects and generate a normalized sample genomic sequence information dataset;applying one or more correction factors derived from a regression analysis of error factors to the normalized sample genomic sequence information dataset to correct for technical effects and generate de-noised sample genomic sequence information dataset; andidentifying copy number variations in the de-noised sample genomic sequence information dataset when a ...

Vented Connector for Medical Fluid Vessels and Tapered Plug

A connector for medical fluid vessels includes a fluid-seal fitting such as a male plug defining a lumen and mating with a cooperating connector, a mechanical fastener such as a screw thread for mating with the cooperating connector, and an outer housing positioned around the plug to form an annular space. A cap can be provided with a fluid-seal fitting such as a male plug for mating with the lumen of the connector. In example embodiments, the male plug is tapered and can comprise one or more projections for sealingly engaging with the lumen of the connector. According to some example embodiments, the cap can be tethered to the connector. 124-. (canceled)25. A connector for connection to a fluid vessel and a cooperating connector , the connector comprising:a first end configured to attach to the vessel, a second end, and a lumen extending through the connector from the first end to the second end;a fluid-seal fitting that at least partially defines the lumen and is configured to sealingly mate with the cooperating connector to provide conveyance of the fluid;an outer housing positioned around the fluid-seal fitting to form an annular space therebetween with an access opening at the second end of the connector, wherein the outer housing comprises a sidewall having at least one vent opening extending therethrough to provide fluid communication between the annular space and external to the annular space; anda cap repositionable between a plugged position capping the second end of the connector and an unplugged position not capping the second end of the connector, the cap including one or more vent openings to provide fluid communication between the annular space and external to the annular space when the cap is in the plugged position capping the access opening of the annular space, wherein the one or more cap vent openings allow for drainage and air-drying of any residual amount of fluid in the annular space,wherein the cap further comprises a plug for providing ...

System, Method, and Apparatus for Dispensing and Monitoring Pharmacy Shipments

Provided is a computer-implemented method for predictively monitoring a shipment of at least one medication order from a first location to a destination location. The method includes receiving a medication order including medication order data identifying at least one medication for a patient, determining predicted environmental conditions for the shipment of the at least one medication from the first location to the destination location based at least partially on the medication order data, determining an optimized packing configuration of at least one of a cooling pack and insulating material for the at least one medication order based at least partially on the predicted environmental conditions, and generating a visual representation of the optimized packing configuration on a display device. A system and computer-program product are also disclosed. 1. A computer-implemented method for predictively monitoring a shipment of at least one medication order from a first location to a destination location , comprising:receiving a medication order comprising medication order data identifying at least one medication for a patient;determining, with at least one processor, predicted environmental conditions for the shipment of the at least one medication from the first location to the destination location based at least partially on the medication order data;determining, with at least one processor, an optimized packing configuration of at least one of a cooling pack and insulating material for the at least one medication order based at least partially on the predicted environmental conditions; andgenerating a visual representation of the optimized packing configuration on a display device.2. The computer-implemented method of claim 1 , further comprising:collecting environmental condition data during shipment of the at least one medication from the first location to the destination location; anddetermining whether the shipment of the at least one medication complies with ...

SOLAR ANTENNA ARRAY FABRICATION

Methods for constructing multi-walled carbon nanotube (MWCNT) antenna arrays, may include: variable doping of the MWCNTs, forming light pipes with layers of variable dielectric glass, forming geometric diodes on full-wave rectified devices that propagate both electrons and holes, using clear conductive ground plans to form windows that can control a building's internal temperature, and generating multiple lithographic patterns with a single mask. 1. A method to construct a center-tapped full-wave rectified multi-walled carbon nanotube (MWCNT) antenna array , the method including: depositing a repeating pattern of interdigitated lines on a glass substrate; growing groups of two MWCNT antennas from a common line to each of two separate adjacent conductive lines; from each group connecting the two MWCNT antennas on the common line by either multiple direct contacts or multiple irregularly grown small carbon nanotubes (CNTs); and depositing a conductive ground plane above the MWCNT antenna array.2. A method as in claim 1 , wherein tips of the MWCNT antennas on the separate conductive lines form geometric diodes.3. A method as in claim 2 , further including growing graphene on the separate conductive lines.4. A method as in claim 3 , wherein the graphene is grown simultaneously with the MWCNT antennas.5. A method as in claim 3 , wherein the graphene is grown prior to growing the MWCNT antennas.6. A method as in claim 3 , wherein the geometric diodes connect to the graphene on the separate conductive lines to form low resistance diodes.7. A method as in claim 6 , wherein the common line is a conductive ground line and the two separate conductive lines are negative voltage lines.8. A method as in claim 7 , wherein the conductive lines include a nickel catalyst.9. A method as in where the nickel catalyst is annealed to control diameters of the MWCNT antennas and to adhere the nickel catalyst to bases of the MWCNT antennas.10. A method as in claim 6 , wherein the common line ...

APPLICATOR SYSTEM FOR APPLYING A VISCOUS LIQUID TO THE HUMAN SKIN

The application relates to an applicator system () for applying a viscous liquid, in particular a transdermal pharmaceutical formulation, to the human skin comprising a metering dispenser () in turn comprising a container holding the viscous liquid and a pump () for metering the liquid and an applicator () detachably connected to the dispenser () and comprising an application surface () for receiving a metered amount of the liquid from the dispenser (). The application surface () is convex. 11. Applicator system () for applying a viscous liquid , in particular a transdermal pharmaceutical formulation , to the human skin comprising{'b': 2', '5, 'a metering dispenser () in turn comprising a container holding the viscous liquid and a pump () for metering the liquid and'}{'b': 3', '2', '6', '2, 'an applicator () detachably connected to the dispenser () and comprising an application surface () for receiving a metered amount of the liquid from the dispenser (),'}{'b': '6', 'characterized in that the application surface () is convex.'}216. Applicator system () according to claim 1 , wherein the application surface () is continuous.316. Applicator system () according to claim 1 , wherein the application surface () is rigid.466. Applicator system () according to claim 3 , wherein the material forming the application surface () has a Young's modulus of at least 1.5 GPa.511. Applicator system () according to claim 3 , wherein the application surface () is smooth.612. Applicator system () according to claim 1 , wherein the dispenser () has a metering accuracy of +/−15% claim 1 , and/or is configured to provide an metered amount per dispense in a range from 0.5 to 2.5 ml.7132. Applicator system () according to claim 1 , wherein the applicator () doubles as a cap for the dispenser ().81382. Applicator system () according to claim 7 , wherein the applicator () comprises a sleeve () to receive and secure the dispenser ().913310. Applicator system () according to claim 8 , wherein ...

System for Increasing the Accuracy of Non Invasive Prenatal Diagnostics and Liquid Biopsy by Observed Loci Bias Correction at Single Base Resolution

Techniques for measuring abundances of sequences includes obtaining first data that indicates a target sequence at a plurality of loci, wherein the target sequence comprises a plurality of bins of loci for which a relative abundance is indicative of a condition of interest. Second data is determined that indicates alignment with the target sequence of reads of DNA fragments in a sample from the subject. Third data is determined that indicates locus dependent observed variations in abundance. A raw count Hj of reads is determined that start at each locus j; and, a copy number of a first bin is determined based on a sum over all loci in the first bin of expected counts for each partition weighted by the locus dependent observed variations. Output data that indicates condition of the subject based at least in part on the copy number of the first bin is presented. 1. A method for measuring nucleic acid sequence abundances comprising:a. obtaining first data that indicates a target sequence of nucleic acid bases at a plurality of loci, wherein the target sequence comprises a plurality of bins of loci for which a relative abundance is indicative of a condition of interest;b. measuring a sample from a subject to obtain reads;c. determining second data that indicates alignment with the target sequence of reads of DNA fragments in a sample from a subject;d. obtaining third data that indicates locus dependent observed variations in abundance;e. determining a raw count Hj of reads that start at each locus j;f. determining a copy number of a first bin based on a sum over all loci in the first bin of expected counts for each partition weighted by the locus dependent observed variations; andg. presenting on a display, output data that indicates condition of the subject based at least in part on the copy number of the first bin.2. A method as recited in claim 1 , further comprising determining in the second data which positions are never covered and adding those positions into a ...

System and method for automatically determining crop characteristics using unmanned aerial vehicle (UAV)

A method and apparatus for automatically determining a characteristic of a crop using an unmanned aerial vehicle (UAV) includes operating the UAV at an elevation above a ground surface of a field and collecting first data that indicates an elevation of the UAV with a barometric pressure based altimeter of the UAV. Second data is collected with a SONAR sensor of the UAV that indicates a distance to a nearest object on the ground surface. The SONAR sensor has a SONAR sensor range and the elevation above the ground surface is less than the SONAR sensor range. The method further includes receiving the first data and the second data on a processor, and determining a height of the nearest object above the ground surface with the processor based on the first data and second data. Output data that indicates the height of the nearest object is presented on a display. 1. A method comprising:operating an unmanned aerial vehicle (UAV) at an elevation above a ground surface of a field;collecting, with a barometric pressure based altimeter of the UAV, first data that indicates an elevation of the UAV above the ground surface;collecting, with a SONAR sensor of the UAV, second data that indicates a distance to a nearest object on the ground surface;receiving, on a processor, the first data and the second data;determining, on the processor, a height of the nearest object above the ground surface based on the first data and the second data; andpresenting on a display device output data that indicates the height of the nearest object,wherein the SONAR sensor has a SONAR sensor range and the elevation above the ground surface is less than the SONAR sensor range.2. A method as recited in claim 1 , further comprising:collecting, with a wind sensor, third data that indicates a wind speed at the ground surface; andreceiving, on the processor, the third data;wherein the determining the height of the nearest object above the ground surface is further based on the third data.3. A method as ...

HAND TORCH, BASE, AND REGULATOR SYSTEM

Provided is a torch including a body having a first portion and a second portion angled relative to the first portion, a control knob at a top of the second portion for adjusting a flow of fuel through the torch, a trigger at a top of the first portion that is movable from an off position to an on position to at actuate an igniter, and a burn tube extending from an end of the second portion away from the first and second portions. 1. A torch including:a body having a first portion and a second portion angled relative to the first portion;a control knob at a top of the second portion for adjusting a flow of fuel through the torch;a trigger at a top of the first portion that is movable from an off position to an on position to at actuate an igniter; anda burn tube extending from an end of the second portion away from the first and second portions.2. The torch according to claim 1 , further including a first valve assembly disposed within the second portion and coupled to the control knob claim 1 , and a second valve assembly fluidly coupled to the first valve assembly and disposed within the first portion to be opened when the trigger moves from the off position to the on position.3. The torch according to claim 2 , wherein the control knob is adjustable to adjust a length of a flame without extinguishing the flame by effecting a ninety-degree turn of the first valve assembly.4. The torch according to claim 2 , further comprising a pivot arm coupled to the trigger and pivotable about a pivot in the first portion claim 2 , and a seesaw disposed in the first portion and pivotable about another pivot in the first portion claim 2 , wherein movement of the trigger from the off position to the on position effects movement of the pivot arm to pivot the seesaw about the another pivot to open the second valve assembly. (currently amended) The torch according to claim 2 , further including a nozzle and flame guide within the burn tube claim 2 , the nozzle being fluidly coupled ...

Sorghum yield enhancement gene

The present disclosure provides nucleic acids that confer a multi-seeded phenotype when expressed in plants and uses thereof.

VENTED CONNECTOR FOR MEDICAL FLUID VESSELS

A connector for medical fluid vessels includes a fluid-seal fitting such as a male plug defining a lumen and mating with a cooperating connector, a mechanical fastener such as a screw thread for mating with the cooperating connector, and an outer housing positioned around the plug to form an annular space. Optionally, a cap can be provided with a fluid-seal fitting such as a male plug for mating with the lumen of the connector. The connector includes one or more vent openings for drainage and air-drying of any residual fluid in the annular space when capped, as well as for breaking a vacuum to prevent fluid backflow and thus ensure more accurate dosing. In some embodiments, the vent openings are provided in the outer housing. And in some embodiments, the vent openings are provided in the cap. 1. A medical tubing connector comprising:a first connector portion configured for connecting to a mating second connector;a tube engagement portion integral with and opposite the first connector portion and configured for connecting to a medical tube;a liquid passage extending along an axis through the first connector portion and the tube engagement portion, the first connector portion including a continuous outer surface for sealing engagement with the mating second connector;an annular portion integral with and surrounding the first connector portion, the annular portion comprising a threaded inner surface; anda connecting portion connecting the first connector portion to the annular portion, the connecting portion including a discontinuity permitting liquid to pass through the connecting portion so that liquid is prevented from pooling between the first connector portion and the annular portion;wherein the connecting portion is defined by spaced apart connecting supports extending between the first connector portion and the annular portion, each connecting support comprising a first section extending from the annular portion and a second section projecting from the first ...

Mutant sorghum bicolor having enhanced seed yield

Genetically altered sorghum plants expressing the multi-seeded #2 phenotype contain one of two genomic alterations in the Sb06g018040 gene which result in reduced activity of the encoded protein, a class II 13-lipoxygenase. This phenotype and genotype are referred to as msd2. These alterations result in increased number of seeds and seed weight, thus increasing the yield of the genetically altered plant. These alterations can be generated in the ortholog genes in maize (TS1), rice, barley, and other monocot plants, generating the MSD2 phenotype. The seeds of one particular MSD2 Sorghum bicolor has been deposited with ATCC and assigned Accession Number PTA-121634.

VENTED CONNECTOR FOR MEDICAL FLUID VESSELS AND TAPERED PLUG

A connector for medical fluid vessels includes a fluid-seal fitting such as a male plug defining a lumen and mating with a cooperating connector, a mechanical fastener such as a screw thread for mating with the cooperating connector, and an outer housing positioned around the plug to form an annular space. A cap can be provided with a fluid-seal fitting such as a male plug for mating with the lumen of the connector. In example embodiments, the male plug is tapered and can comprise one or more projections for sealingly engaging with the lumen of the connector. According to some example embodiments, the cap can be tethered to the connector. 1. A cap for sealing with a lumen of a male connector , the cap comprising:a body comprising an upper surface and a lower surface, the upper surface comprising a handle extending therefrom and the lower surface comprising a plug extending therefrom, the plug comprising a first end engaged with the lower surface and a second end axially extending therefrom,wherein the plug comprises at least one projection extending therefrom for sealing engagement with the lumen of the male connector.2. The cap of claim 1 , wherein the plug comprises an elongate body and an outer peripheral surface claim 1 , and wherein the plug tapers from the first end to the second end.3. The cap of claim 1 , wherein the plug comprises a length of about 5 millimeters.4. The cap of claim 1 , wherein the at least one projection comprises a rib-like ring projecting around the entire periphery of the outer peripheral surface of the plug body claim 1 , and wherein an outer surface of the rib-like ring is configured for providing an interference fit with an internal surface of the lumen of the male connector.5. The cap of claim 1 , wherein the plug comprises two or more projections.6. The cap of claim 1 , wherein the plug comprises four spaced-apart projections claim 1 , each of the projections extending around the entire periphery of the plug.7. The cap of claim 1 , ...

INTERNAL THERMAL TRANSFER FOR MEMORY DEVICE

Apparatuses, systems, and methods are presented for data storage with internal thermal transfer. A plurality of memory elements may be disposed within a thermally conductive housing. A controller may be disposed within the housing and thermally connected to the housing. A heat spreader may be thermally connected to the housing and to the plurality of memory elements, and not thermally connected to the controller. 1. An apparatus comprising:a thermally conductive housing;a plurality of memory elements disposed within the housing;a controller disposed within the housing and thermally connected to the housing; anda heat spreader thermally connected to the housing and to the plurality of memory elements, and not thermally connected to the controller.2. The apparatus of claim 1 , wherein the heat spreader is disposed to provide thermal communication among the memory elements and to provide a thermal break between the controller and the memory elements.3. The apparatus of claim 1 , wherein a first portion of the heat spreader claim 1 , where the heat spreader contacts the housing claim 1 , is directly across the heat spreader from a second portion of the heat spreader claim 1 , where the heat spreader contacts the memory elements.4. The apparatus of claim 1 , wherein claim 1 , the controller is thermally connected to the housing such that during operation of the controller and the memory elements claim 1 , at least a portion of the housing proximate to the controller is hotter than the memory elements.5. The apparatus of claim 1 , wherein thermal connections between the controller and the housing claim 1 , between the heat spreader and the housing claim 1 , and between the heat spreader and the memory elements include a thermal interface material (TIM).6. The apparatus of claim 5 , wherein the heat spreader is formed from a material with a thermal conductivity at least ten times greater than a thermal conductivity of the TIM.7. The apparatus of claim 5 , wherein the heat ...

Techniques for fractional component fragment-size weighted correction of count and bias for massively parallel DNA sequencing

Techniques for automated determination or correction of count bias are based on probability of fraction fragment size for a particular fractions, such as a minority fraction contributed to a sample by fetal or tumor DNA. The techniques include determining a probability density function of fragment sizes for a particular fractional component of the sample; and determining a fraction f of the sample associated with the particular fractional component. A raw count of reads that start at each locus in the target sequence is determined for each fragment i of size s. A corrected count is determined by multiplying the raw count for each fragment i with a weighting factor cthat depends on the fraction f and the probability density function value for the fragment size s. The corrected count is used for determining a condition of interest in the particular fractional component. 1. A method executed on a processor comprising:obtaining first data that indicates a target sequence of nucleic acid bases at a plurality of loci, wherein the target sequence comprises a plurality of bins of loci for which a relative abundance is indicative of a condition of interest;obtaining second data that indicates alignment with the target sequence of reads of DNA fragments in a sample comprising multiple fractional components;obtaining a probability density function of fragment sizes for a particular fractional component of the sample;obtaining a fraction f of the sample associated with the particular fractional component;{'sub': 'i', 'determining a raw count of reads that start at each locus in the target sequence for each fragment i of size s;'}{'sub': i', 'i, 'determining a corrected count by multiplying the raw count for each fragment i with a weighting factor cthat depends on the fraction f and a value of the probability density function for the fragment size s; and'}using the corrected count for determining the condition of interest in the particular fractional component.2. A method as ...

System and Method for Construction of Internal Controls for Improved Accuracy and Sensitivity of DNA Testing

Techniques for construction of internal controls for improved accuracy and sensitivity of DNA testing include obtaining first data and determining weights over real numbers for a normalization function in less than a day. The first data indicates a measured amount of reference sequences for nucleic acids from training samples. The reference sequences include a target, for which an abundance is indicative of a condition of interest, and covariates not correlated with the condition of interest. The normalization function involves a sum of abundances of the covariates, as internal controls, each multiplied by a corresponding one of the weights. The weights are determined based on minimizing variance of a Taylor expansion of a ratio of a measured amount of the target divided by a value of the normalization function evaluated with measured amounts of the covariates over a portion of the first data in which the condition is absent. 1. A method comprising: a target reference sequence for which a relative abundance compared to other reference sequences is indicative of a condition of interest, and', 'a set of one or more covariate reference sequences different from the target reference sequence, wherein a relative abundance of each of the covariate reference sequences is not correlated with the condition of interest; and, 'obtaining on a processor first data that indicates a measured amount of each of a plurality of reference sequences for nucleic acids from each of a plurality of training samples, wherein the plurality of reference sequences includes'}determining automatically on a processor a value over real numbers for each weight of a set of one or more weights for a normalization function that involves a sum of relative abundances of the set of one or more covariate reference sequences, each relative abundance multiplied by a corresponding one of the set of one or more weights, based on minimizing a variance of a Taylor expansion of a ratio of a measured amount of the ...

A System and Method for Compensating Noise in Sequence Data for Improved Accuracy and Sensitivity of DNA Testing

Some techniques for compensating noise in nucleotide sequencing data include smoothing data for a first reference sequence based on amounts of a subset of reference sequences. An amount of each reference sequence of the subset is multiplied by a corresponding smoothing factor for the reference sequence. The smoothing factor for the reference sequence is based on a spread of the amounts of the reference sequence in the training data. Some techniques include applying a hidden Markov model in which hidden states represent normal condition and a condition of interest at each of multiple pairs of complementary fractions of the sample exhibiting the condition. Transitions from a non-normal condition at a first fraction are confined to states at the first fraction. The normal condition at the first fraction can transition to a state of a different fraction only if the different state represents the normal condition at a complementary fraction. 1. A method comprising:obtaining on a processor first data that indicates an amount of each of a plurality of reference sequences for nucleic acids from each of a plurality of training samples, wherein the plurality of reference sequences includes a target reference sequence for which a relative abundance compared to other reference sequences is indicative of a condition of interest;determining automatically on the processor a plurality of spreads of the amounts corresponding to the plurality of reference sequences, wherein each spread corresponding to the amounts of each reference sequence is based on a measure of spread in a portion of the first data for the reference sequence among the plurality of training samples;obtaining on a processor second data that indicates an amount of each of the plurality of reference sequences from a sample from a subject, wherein the sample is different from the plurality of training samples;determining automatically on a processor smoothed second data that indicates a smoothed amount of a first ...

SYSTEMS AND METHODS FOR USING DENSITY OF SINGLE NUCLEOTIDE VARIATIONS FOR THE VERIFICATION OF COPY NUMBER VARIATIONS IN HUMAN EMBRYOS

A method for verifying a genomic variant region in an embryo, is disclosed. Embryo sequencing data is received by one or more processors. The received embryo sequencing data is aligned to a reference genome, by the one or more processors. A genomic variant region is identified in the aligned embryo sequencing data, by the one or more processors. A number of single nucleotide variants (SNVs) is counted in the identified genomic variant region, by the one or more processors. The counted number of SNVs in the identified genomic variant region is normalized against a baseline count of SNVs for a reference region corresponding to the identified genomic variant region to generate a normalized SNV density for the genomic variant region, by the one or more processors. The identified genomic variant region is verified, by the one or more processors, if the normalized SNV density in the identified genomic variant region satisfies a tolerance criterion. 1. A method for verifying a genomic variant region in an embryo , comprising:receiving, by one or more processors, embryo sequencing data;aligning, by the one or more processors, the received embryo sequencing data to a reference genome;identifying, by the one or more processors, a genomic variant region in the aligned embryo sequencing data;counting, by the one or more processors, a number of single nucleotide variants (SNVs) in the identified genomic variant region;normalizing, by the one or more processors, the counted number of SNVs in the identified genomic variant region against a baseline count of SNVs for a reference region corresponding to the identified genomic variant region to generate a normalized SNV density for the genomic variant region; andverifying, by the one or more processors, the identified genomic variant region, if the normalized SNV density in the identified genomic variant region satisfies a tolerance criterion.2. The method of claim 1 , wherein the genomic variant region is a copy number variation ...

SYSTEMS AND METHODS FOR DETERMINING GENOME PLOIDY

A method for detecting ploidy in an embryo is provided, comprising receiving an embryo sequence data; aligning the received sequence data to a reference genome; identifying a region of interest in the aligned embryo sequence data; identifying single nucleotide polymorphisms (SMPs) in the sequence data by comparing the received sequence data to the aligned reference genome; determining a ploidy score comprising counting the number of observed SNPs in the region of interest; comparing the ploidy score to a predetermined threshold; and identifying the embryo as polyploid if the ploidy score is below the predetermined threshold. 1. A method for detecting ploidy in an embryo , comprising:receiving an embryo sequence data;aligning the received sequence data to a reference genome;identifying a region of interest in the aligned embryo sequence data;identifying single nucleotide polymorphisms (SMPs) in the sequence data by comparing the received sequence data to the aligned reference genome;determining a ploidy score comprising counting the number of observed SNPs in the region of interest;comparing the ploidy score to a predetermined threshold; andidentifying the embryo as polyploid if the ploidy score is below the predetermined threshold.2. The method of claim 1 , further comprising identifying the embryo as euploid if the ploidy score is above the predetermined threshold.3. The method of claim 1 , wherein the polyploid is a balanced polyploid.4. The method of claim 1 , wherein the embryo sequence data is acquired by low-coverage sequencing.5. The method of claim 4 , wherein the low-coverage sequencing is between about 0.001 and 10×.6. The method of claim 4 , wherein the low-coverage sequencing is between about 0.01 and 0.5×.7. The method of claim 4 , wherein the low-coverage sequencing is between about 0.25 and 0.2×.8. (canceled)9. (canceled)10. (canceled)11. (canceled)12. A non-transitory computer-readable medium storing computer instructions for detecting ploidy in an ...

SYSTEM AND METHOD FOR DETERMINING GENETIC RELATIONSHIPS BETWEEN A SPERM PROVIDER, OOCYTE PROVIDER, AND THE RESPECTIVE CONCEPTUS

A method for determining the genetic relationship of a conceptus with sperm and oocyte providers is provided, comprising receiving conceptus, sperm provider, and oocyte provider sequence data; aligning the received sequence data to a reference genome; identifying single nucleotide polymorphisms (SNPs) in the sperm provider, oocyte provider, and conceptus sequence data; imputing missing gaps in the sperm provider sequence data and the oocyte provider sequence data using an imputation reference; calculating a paternal consistency score between the sperm provider and the conceptus; calculating a maternal consistency score between the oocyte provider and conceptus; and classifying the sperm provider and/or the oocyte provider as related to the conceptus if the paternal consistency score and/or the maternal consistency score exceeds the predetermined threshold. 1. A method for determining the genetic relationship of a conceptus with a sperm provider and oocyte provider , comprising:receiving conceptus, sperm provider, and oocyte provider sequence data;aligning the received sequence data to a reference genome;identifying single nucleotide polymorphisms (SNPs) in the sperm provider, oocyte provider, and conceptus sequence data;imputing missing gaps in the sperm provider sequence data and the oocyte provider sequence data using an imputation reference;calculating a paternal consistency score between the sperm provider and the conceptus, the score comprising (a) a count of SNPs that are common between the conceptus and sperm provider and (b) a count of SNPs found in the conceptus but not the sperm provider;calculating a maternal consistency score between the oocyte provider and conceptus, the score comprising (a) a count of SNPs that are common between the conceptus and oocyte provider and (b) a count of SNPs found in the conceptus but not the oocyte provider; andclassifying the sperm provider and/or the oocyte provider as related to the conceptus if the paternal consistency ...

Aqueous based solvent free degreaser composition comprising a ternary mixture of nonionic alkoxylates

An aqueous based, solvent free degreaser composition, has on a weight basis: a) about 0.5-10% of at least one alcohol alkoxylate with a fatty alcohol moiety selected from the group of compounds having the formula: ##STR1## wherein R is a C 8 to C 18 branched or straight chain alkyl group, m is within the range of about 0 to 14, n is within the range of about 0 to 14, o is within the range of about 0-14, p is within the range of about 0-14, and R' is --CH 3 , --CH 2 CH 3 , and mixtures thereof, R" is --CH 3 , --CH 2 CH 3 , and mixtures thereof, and R'" is --OH, --CH 3 , --O--C 3 -C 18 hydroxyalkyl group and mixtures thereof; b) about 0.5-10% of at least one alkyl phenol alkoxylate of the following formula: ##STR2## wherein R is a C 8 or C 9 branched or straight chain alkyl group, m is within the range of about 3 to 12, and n is within the range of about 0 to 12, and P is a phenyl group; c) about 0.5-10% of at least one alkyl oxyethylate of the following formula: R(O CH.sub.2 CH.sub.2).sub.x OH wherein R is a C 10 to C 13 branched or straight chain alkyl group and x is within the range of about 4 to 10; and d) water.

Process for antibody directed enzyme prodrug therapy

Prodrugs, of generic formula I, are disclosed for use in antibody directed enzyme prodrug therapy (ADEPT). The prodrugs are substrates for carboxypeptidase G2 (CPG2) and yield more active cytotoxic drugs than known products of CPG2 catalysed reactions.

Methods of forming metal matrix composite bodies by a spontaneous infiltration process

The present invention relates to a novel process for forming metal matrix composite bodies. Particularly, an infiltration enhancer and/or an infiltration enhancer precursor and/or an infiltrating atmosphere are in communication with a filler material (2) or a preform, at least at some point during the process, which permits molten matrix metal (3) to spontaneously infiltrate the filler material (2) or preform. Such spontaneous infiltration occurs without the requirement for the application of any pressure or vacuum.

Flotation process for the formation of metal matrix composite bodies

The present invention relates to a novel method for forming metal matrix composite bodies. Particularly, a permeable mass of filler material is formed into a preform. The preform material can then be floated onto the surface of or into a matrix metal alloy, whereupon the matrix metal alloy spontaneously infiltrates the preform. After substantial complete infiltration of the preform, the preform begins to at least partially sink into the matrix metal alloy supply. The matrix metal which has infiltrated the preform is then allowed to cool, thus forming a metal matrix composite body.

Pollen-based transformation system using solids

Transmitter For Transmitting A Secure Access Signal

A transmitter ( 116 ) for transmitting a secure access signal to a system ( 117 ) for providing secure access to a controlled item ( 111 ) is disclosed. The access is dependent on information contained in the secure access signal. The transmitter ( 116 ) comprises a biometric sensor ( 121 ) for receiving a biometric signal and a processor ( 1005 ) for matching the biometric signal against members of a database ( 105 ) of biometric signatures. The transmitter ( 116 ) comprises enabling means (e.g., 127 ) for enabling an inductive circuit, based on the matching of the biometric signal, to transmit the secure access signal conveying the information to the system ( 117 ) upon the inductive circuit being placed within range of a radio frequency field emitted by the system ( 117 ).

Pollen-based transformation system using solid media

A medium is disclosed that supports pollen germination and pollen tube growth in the presence of Agrobacterium, the medium comprising agarose, sucrose, NO 3 , MnSO 4 , H 3 BO 3 , MgSO 4 and gibberellic acid. A method is disclosed for the genetic transformation of plants and lines by a pollen-based Agrobacterium-mediated transformation. The method comprises the steps of obtaining pollen from a first plant, applying a lawn of Agrobacteria to a solid pollen culture medium, the Agrobacterium comprising at least one heterologous gene sequence capable of being transferred to a plant cell, applying the pollen to the solid medium, allowing the pollen to germinate and grow on the medium, whereby the Agrobacterium attaches to the pollen tube or mediates transfer of the heterologous gene sequence to the germinating pollen to obtain transgenic pollen, applying the transgenic pollen to the stigma of a second plant capable of being fertilized by the pollen of the first plant, thereby fertilizing the second plant, obtaining transgenic seed from the second plant and germinating the transgenic seed to obtain a transgenic plant. The method is particularly suited for use with so-called "dry stigma" pollen.

Multilayer membrane useful as synthetic skin

A multilayer membrane, which is useful as synthetic skin, is disclosed herein. A first layer is formed from a material which does not provoke an immune response and which is also insoluble and nondegradable in the presence of body fluids and/or body enzymes. Preferred materials for the first layer are crosslinked composites of collagen and a mucopolysaccharide. A second layer is formed from a nontoxic material which controls the moisture flux of the overall membrane to about 0.1 to 1 mg./cm 2 /hr. Suitable materials for the second layer include synthetic polymers such as silicone resins, polyacrylate or polymethacrylate esters or their copolymers, and polyurethanes.

Partition defined detection methods

Methods are disclosed for resolving measurement problems such problems in measuring chromosomal copy number. Some disclosed methods involve first selecting a primary assay element characteristic to partition. Such characteristic may be a source of experimental variability such as the GC content of measured DNA sequences. Additionally, the disclosed methods may employ an abundance or copy number function to transform the assay element frequencies into an abundance, dose, copy number score, or the like. In some cases, the disclosed methods estimate an amount of certain fetal DNA in a sample. The methods can further compare the estimated amount to a measured amount of fetal DNA in the sample. The comparison can be used to determine the fetal sex or aneuploidy.

Resolving genome fractions using polymorphism counts

Synthetic herbicide resistance gene

Selection procedure for identifying transgenic cells, embryos, and plants without the use of antibiotics

Transgenic cells may be selected using temperature sensitive marker proteins. In this method, a population of host cells are transformed with a foreign DNA construct which includes at least one first nucleic acid coding sequence and a second nucleic acid sequence encoding a temperature sensitive marker protein, wherein each of the first and second nucleic acid coding sequences are operatively linked to gene expression control sequences. Suitable temperature sensitive marker proteins which may be used herein include heat shock proteins, heat shock transcription factors, cold regulated proteins (COR), or cold regulated protein transcription factors. Following transformation, the population of cells are cultured under temperature conditions wherein growth of non-transformed cells is suppressed or prevented while growth of cells transformed with the DNA construct is supported or promoted. Thus, survival and/or significant growth of a cell is an indication that the cell has been successfully transformed with the DNA construct. Those cells are considered presumptively positive transformants, and may be recovered.

Synthetic herbicide resistance gene

The invention provides a DNA molecule, a DNA construct, a transgenic plant and a transgenic plant part comprising a synthetic DNA sequence. The synthetic DNA sequence encodes an enzyme that degrades 2,4-dichlorophenoxyacetic acid (2,4-D) to dichlorophenol. The synthetic DNA sequence comprises a natural microbial sequence that encodes the enzyme in which at least a plurality of the codons of the natural microbial sequence have been replaced by codons more preferred by a plant. The invention also provides a method of controlling weeds in a field containing transgenic plants according to the invention by applying an auxin herbicide, such as 2,4-D, to the field. The invention further provides methods of selecting plants and plant cells that have been transformed with a DNA construct according to the invention using an auxin herbicide.

BLOOD COMPATIBLE COLLAGEN-MUCOPOLYSACCHARIDE COMPOSITE MATERIALS

FLUID ASSISTED SERVOMOTOR, IN PARTICULAR FOR BRAKING CIRCUIT

CE SERVOMOTEUR COMPORTE UNE TIGE D'ENTREE 111 PORTANT UN ORGANE DE POUSSEE 112, UNE TIGE DE SORTIE 117 PORTANT UNE TETE DE PISTON 116 ET UN DISQUE 115 EN CAOUTCHOUC MONTE ENTRE L'ORGANE DE POUSSEE ET LA TETE DE PISTON. LA TETE DE PISTON COMPORTE UN ALESAGE AXIAL 119 ET L'ORGANE DE POUSSEE COMPORTE UN PROLONGEMENT 121 QUI TRAVERSE LE DISQUE ET PENETRE DANS L'ALESAGE. LE PROLONGEMENT EST ANCRE A LA TETE DE PISTON PAR UN CAPUCHON 122 MONTE SUR LA TETE, CE QUI PERMET A L'ORGANE DE POUSSEE D'EFFECTUER UN CERTAIN DEPLACEMENT VERS L'AVANT POUR APPLIQUER UNE CHARGE AU DISQUE MAIS LIMITE LA SEPARATION AXIALE DE LA TETE DE PISTON ET DE L'ORGANE DE POUSSEE LORS DE LA COURSE EN RETOUR. APPLICATION, NOTAMMENT, A UN SERVOMOTEUR DE FREIN A DEPRESSION. THIS SERVOMOTOR INCLUDES AN INPUT ROD 111 BEARING A PUSH-BODY 112, AN OUTPUT ROD 117 BEARING A PISTON HEAD 116 AND A RUBBER DISC 115 MOUNTED BETWEEN THE PUSH-BUTTON AND THE PISTON HEAD. THE PISTON HEAD HAS AN AXIAL BORE 119 AND THE PUSHING UNIT HAS AN EXTENSION 121 WHICH CROSSES THE DISC AND PENETS INTO THE BALEAGE. THE EXTENSION IS ANCHORED TO THE PISTON HEAD BY A CAP 122 MOUNTED ON THE HEAD, WHICH ALLOWS THE PUSHING BODY TO MAKE A CERTAIN MOVEMENT FORWARD TO APPLY A LOAD TO THE DISC BUT LIMITS THE AXIAL SEPARATION OF THE PISTON HEAD AND PUSHING BODY DURING RETURN RACE. APPLICATION, IN PARTICULAR, TO A VACUUM BRAKE SERVOMOTOR.

AUTOMATIC WEAR RESTRAINING MECHANISM FOR DRUM BRAKES

CE MECANISME COMPORTE DEUX ORGANES FILETES 23, 24 COMPORTANT UN DISPOSITIF D'AVANCE PAS A PAS 26, 27, 28 POUR PROVOQUER LEUR ROTATION RELATIVE LORS DE L'ACTIONNEMENT DU FREIN DE SERVICE, L'AXE DE CES ORGANES COUPANT LA LIGNE D'ACTION ENTRE L'UNE 11 DES MACHOIRES DE FREIN ET UNE BUTEE 21 QUI LIMITE LE MOUVEMENT DE RETOUR DE LA MACHOIRE, L'UN DES ORGANES FILETES 24 COMPORTANT UNE PIECE D'ESPACEMENT 25 DISPOSEE ENTRE LA MACHOIRE ET LA BUTEE, LA ROTATION RELATIVE DES ORGANES FILETES MODIFIANT L'EFFET D'ESPACEMENT DE LA PIECE D'ESPACEMENT ET, DE CE FAIT, LA POSITION DE DESSERRAGE DU FREIN DE LA MACHOIRE. APPLICATION AUX FREINS A TAMBOURS POUR VEHICULES. THIS MECHANISM INCLUDES TWO THREADED PARTS 23, 24 INCLUDING A STEP-BY-STEP ADVANCE DEVICE 26, 27, 28 TO PROMOTE THEIR RELATIVE ROTATION WHEN THE SERVICE BRAKE IS ACTUATED, THE AXIS OF THESE PARTS CUTTING THE LINE OF ACTION BETWEEN ONE 11 OF THE BRAKE SHOES AND A STOPPER 21 WHICH LIMITS THE RETURN MOVEMENT OF THE SHOE, ONE OF THE THREADED PARTS 24 INCLUDING A SPACER 25 PLACED BETWEEN THE SHOE AND THE STOPPER, THE RELATIVE ROTATION OF THE ORGANS THREADS MODIFYING THE SPACING EFFECT OF THE SPACER AND, THEREFORE, THE RELEASE POSITION OF THE JAW BRAKE. APPLICATION TO DRUM BRAKES FOR VEHICLES.

Method of combating infection

A method of combating a parasitic protozoal infection of a host organism, the method comprising administering tretazicar to the host organism. Tretazicar is the compound 5-(aziridin-l-yl)-2,4-dinitrobenzamide (CB 1954), and the parasitic infection is preferably an infection of Trypanosoma cruzi, T. b. brucei, Leishmania spp. particularly L. infantum, Cryptosporidium or Giardia spp.

Astronomical clock

An investment casting technique for the formation of metal matrix composite bodies and products produced thereby

Matrix-handling means

Metal cleaning process

ABSTRACT OF THE DISCLOSURE Processes are provided for cleaning metal in preparation for painting, coating, welding or other subsequent process. The processes all include rinsing the metal with a solution of deionized water and a water soluable amine having a vapor pressure of at least about 10% of the vapor pressure of water at 20° C resulting in an essentially residue and water spot free surface promoting welding and bonding of the paint or coating thereto as will enhancing other subsequent processes that may be scheduled therefore.

CASTING TECHNIQUES FOR THE CREATION OF COMPOSITIONS WITH METAL MATRIX

Detection of sleep-disordered breathing

A system to form and store an electrocardiogram (ECG) signal derived from a cardiac electrical signal that includes an apparatus having a pair of the electrodes (23) to connect to a patient to detect the cardiac electrical signal. A signal sampler (27) samples the cardiac electrical signal to form the ECG signal. A data storage device (29) stores the ECG signal. A computer (31) communicates with the data storage device to retrieve the ECG signal for analysis by software stored in the memory (33) of the computer. The software analyzes a morphology of the amplitude of a plurality of R-wave peaks contained within the ECG signal and/or analyzes a morphology of the area of a plurality of QRS complex pulses contained within the ECG signal.

Vehicle transmission

Method and apparatus for enhancing growth characteristics of seeds using ion-electron avalanches

Peak respiratory flow monitor

A peak respiratory flow monitor utilizes an enclosure having a series of openings through the wall thereof, a provision for covering a desired number of these openings, and a provision for generating a signal when the air flow through the enclosure reaches a threshold. In a preferred embodiment the enclosure includes an elongated tubular member, and the threshold indicator is a reed placed in a chamber that has an adjustable valve for calibrating the flow past the reed. Furthermore, the chamber causes a displacement of flow from along the longitudinal axis of the tubular member.

Cell-seeding procedures involving fibrous lattices.

Introduction de cellules viables dans un treillis fibreux par des techniques chirurgicales, utilisant une force ou d'autres manipulations, désignées ici sous le nom d'"ensemencement". Un mode de réalisation comprend une technique d'auto-greffage qui recquiert des tissus intacts. D'autres modes de réalisation qui entraînent la distribution d'une suspension aqueuse de cellules comprennent des étapes de centrifugation, de vaporisation, de pippetage et d'emplacement dans une seringue. Chaque cellule qui survit au procédé d'ensemencement peut se reproduire en une colonie de cellules qui croissent jusqu'à se rejoindre, créant ainsi une couche ou un volume uniforme de tissu. Par une disposition appropriée des cellules capables de produire de telles colonies, la période de rétablissement d'une blessure peut être réduite considérablement. En outre, les recherches effectuées par les déposants indiquent que les tissus régénérés en utilisant les procédés de la présente invention consistant à ensemencer un treillis comprenant du collagène et du glycosaminoglycane tendent à être plus uniformes, plus lisses, plus flexibles et présentent moins de fibres et de cicatrices que les tissus régénérés par contraction de la blessure ou par des techniques conventionnelles d'auto-greffage. Introduction of viable cells into a fibrous mesh by surgical techniques, using force or other manipulations, referred to herein as "seeding". One embodiment includes an auto-grafting technique that requires intact tissue. Other embodiments which result in the distribution of an aqueous suspension of cells include steps of centrifugation, vaporization, pipetting and placement in a syringe. Each cell that survives the seeding process can reproduce as a colony of cells that grow until they join, creating a uniform layer or volume of tissue. By proper arrangement of cells capable of producing such colonies, the recovery period from injury can be reduced ...

A method for placing a photo-cross-linking agent at specific internal sites within the sequence of synthetic strands of ribonucleic acids

This invention describes novel photoactive ribonucleotides that contain phot o- cross-linking agents placed at specific internal positions within a ribonucleotide. The invention also provides methods for identifying novel, sequence-specific target molucules, using the photoactive ribonucleotides of the invention, as well as improved nucleic acid hybridization analysis metho ds.

Friction clutch driven plate

A motor vehicle friction clutch driven plate having a hub (11) and a facing carrier (16) (19) mounted on the hub and capable of limited rotation about the hub (11). Resilient damping members (21) act between the hub and carrier for damping out drive load oscillations and an auxiliary resilient damping members (25) also acts between the hub and carrier to damp out idling loads. The resilient damping members (21) are each a snug fit in either the hub (11) or carrier (16) (19) and a loose fit in the other (11) or (16) (19). The auxiliary damping member (25) is arranged end to end with at least one of the resilient means (21) to bias said resilient member (21) ('B') towards one end of its aperture in which it is a loose fit. <IMAGE>

Recovery by vapor recompression of industrial process fluid components

The invention provides the combined use of UF and MVR for the treatment of industrial process fluid wastewater that contains recoverable material The recoverable material desirably has a molecular diameter of less than about 5 to 6 nm and a boiling point of less than about 200 0C In one embodiment, the recoverable material may then be utilized in the preparation of another industrial process fluid In another embodiment, the recoverable material is isolated and retained for later use. The invention thereby provides aqueous industrial process fluid which contains water, one or more of an emulsifier, oil, amine, biocide, thickener, lubricant, dispersant, antioxidant, corrosion inhibitor, alkaline compound, surfactant, and earner; and one or more chemical compounds recovered from aqueous industrial process fluid wastewater treated with UF and MVR.

Therapeutic systems for activation prodrugs

A compound comprising a target cell-specific portion and human NAD(P)H:quinone reductase 2 (NQO2) or a variant or fragment or fusion or derivative thereof which has substantially the same activity as NQO2 towards a given prodrug, or a polynucleotide encoding said NQO2 or said variant or fragment or fusion or derivative. A recombinant polynucleotide comprising a target cell-specific promoter operably linked to a polynucleotide encoding human NAD(P)H:quinone reductase 2 (NQO2) or a variant or fragment or fusion or derivative thereof which has substantially the same activity as NQO2 towards a given prodrug. The compounds and polynucleotides are useful in a method of treating a patient in conjunction with a suitable prodrug. A method of treating a human patient with a target cell to be destroyed wherein the target cell expresses NQO2 the method comprising administering to the patient a prodrug which is converted to a substantially cytotoxic drug by the action of NQO2 and nicotinamide riboside (reduced) (NRH) or an analogue thereof which can pass reducing equivalents to NQO2.

Systems and methods for determining pattern of inheritance in embryos

A method for determining pattern of inheritance in an embryo for a region of interest is provided, comprising receiving embryo, maternal and paternal sequence data; aligning the received sequence data to a reference genome; identifying a region of interest in the aligned embryo sequence data; identifying single nucleotide polymorphisms (SNPs) in the maternal sequence data, paternal sequence data, and the identified region of interest in the embryo sequence data; imputing missing gaps in the maternal sequence data and the paternal sequence data using an imputation reference; counting the number of SNPs that are common between the embryo and the mother/father in the identified region of interest for the embryo sequence data and a corresponding region on the maternal/paternal sequence data to determine a maternal/paternal contribution value; and classifying a pattern of inheritance for the embryo as maternal or paternal based on the relative contribution values between mother and father.

Leverless scale sensor

ABSTRACT OF THE DISCLOSURE This weighing scale has a platform, a load cell supporting the platform and a base supporting the load cell. The load cell utilizes electrical strain gage elements, which are connected in an electrical circuit controlling an indicator. The scale is constructed to be unaffected by the eccentricity of the load on the platform. The scale is particularly suited for use in retail or other establishments, where loads are placed on the platform casually and rapidly, so that eccentric loading is common. The load cell comprises an integral block of material divided by milled apertures and recesses into two vertical members and three horizontal members connecting the vertical members. The platform is supported on one of the vertical members. The base is connected to the other vertical member. The upper and lower horizontal members carry most of the bending moments due to eccentric loads from one vertical member to the other. The middle horizontal member is constructed so that it carries most of the vertical component of the load. The strain gage elements are on this middle horizontal member and thus measure only the vertical load.

Resolving genome fractions using polymorphism counts

Methods of reliably estimating genomic fraction (e.g., fetal fraction) from polymorphisms such as small base variations or insertions-deletions are disclosed. Sequenced data from a multigenomic source is used to determine allele counts for one or more of the polymorphisms. For one or more of the polymorphisms, zygosity is assigned, and genomic fraction is determined from the zygosity and allele counts. Certain embodiments employ SNPs as the relevant polymorphism. The disclosed methods can be applied as part of an intentional, pre-designed re-sequencing study targeted against known polymorphisms or can be used in a retrospective analysis of variations found by coincidence in overlapping sequences generated from maternal plasma (or any other setting where a mixture of DNA from several people are present).

Formation of metal matrix composites by immersion casting technique

Sealing device

Method of combating infection

An investment casting technique for the formation of metal matrix composite bodies and products produced thereby

The present invention relates to a novel method for forming metal matrix composite bodies and the novel products produced therefrom. A negative shape or cavity, which is complimentary to the desired metal matrix composite body to be produced, is first formed. The formed cavity is thereafter filled with a permeable mass of filler material. Molten matrix metal is then induced to spontaneously infiltrate the filled cavity. Particularly, an infiltration enhancer and/or an infiltration enhancer precursor and/or an infiltrating atmosphere are also in communication with the filler material, at least at some point during the process, which permits the matrix metal, when made molten, to spontaneously infiltrate the permeable mass of filler material, which at some point during the processing, may become self-supporting. In a preferred embodiment, cavities can be produced by a process which is similar to the so-called lost-wax process.

Improvements in or relating to speed indicating and theft warning devices for motor vehicles

1,215,470. Indicating unauthorized operation of vehicles. J. M. BURKE. 20 Dec., 1967 No. 57753/67. Heading B7J. [Also in Divisions G1, G4] A device for indicating unauthorized use of a vehicle comprises a treble pole switch and three amber lights connected one to each pole. The lights, which are mounted on the floor of the vehicle, are not visible to the driver and are obscured to a viewer outside the vehicle by a sliding cover moved into position when the handbrake is applied. A cable is attached to the handbrake and the cover for moving the cover to obscure the light when the handbrake is on whilst a spring attached to an anchor point of the vehicle and the cover holds the cover in the open position when the handbrake is off. The vehicle owner, on leaving the car, closes the switch which is key operated so that a thief on releasing the handbrake and switching on the ignition causes one of the amber lights to be switched on. The three amber lights are connected through contacts on the speedometer and other lights which give a visible indication of the speed at which the vehicle is travelling, the amber lights being so connected that one is always switched on during the unauthorized use irrespective of the speed of the vehicle. The three pole switch may be provided with a rubber suction disc so that it can be placed in any position.

Method of combating infection

A method of combating a parasitic protozoal infection of a host organism, the method comprising administering tretazicar to the host organism. Tretazicar is the compound 5-(aziridin-l-yl)-2,4-dinitrobenzamide (CB 1954), and the parasitic infection is preferably an infection of Trypanosoma cruzi, T. b. brucei, Leishmania spp. particularly L. infantum, Cryptosporidium or Giardia spp.

Lift mechanism for framing nailer

System, method, and apparatus for dispensing and monitoring pharmacy shipments

Method and apparatus for enhancing growth characteristics of seeds using ion-electron avalanches

Cell-seeding into fibrous lattices by means of centrifugation

CELL-SEEDING INTO FIBROUS LATTICES BY MEANS OF CENTRIFUGATION ABSTRACT This invention comprises the use of centrifugal force to introduce viable cells into a fibrous lattice, as well as fibrous lattices that are seeded with cells by the use of centrifugal force. A variety of fibrous lattices may be seeded by the methods of this invention, such as a highly porous lattice comprising collagen fibers crosslinked with glycosaminoglycan. Before the centrifugation, a piece of intact tissue is harvested from a donor site. It is treated with one or more substances, such as trypsin or collagenase, to dissociate cells from the tissue. The cells are then mixed with an aqueous solution to create an aqueous suspension of cells. A piece of fibrous lattice is placed within a container, referred to herein as a "bucket," that is suitable for rotation by a centrifuge. The aqueous suspension of cells is placed within the bucket, in contact with the lattice. The centrifuge is then rotated. Centrifugal force causes the cells, which are denser than the aqueous solution, to be forced into the lattice in a relatively uniform distribution. By controlling various parameters, cells can be seeded into any desired location within a lattice.

System, software, and method for detection of sleep-disordered breathing using an electrocardiogram

A system to form and store an electrocardiogram (ECG) signal derived from a cardiac electrical signal that includes an apparatus having a pair of the electrodes to connect to a patient to detect the cardiac electrical signal. A signal sampler samples the cardiac electrical signal to form the ECG signal. A data storage device stores the ECG signal. A computer communicates with the data storage device to retrieve the ECG signal for analysis by software stored in the memory of the computer. The software analyzes a morphology of the amplitude of a plurality of R-wave peaks contained within the ECG signal and/or analyzes a morphology of the area of a plurality of QRS complex pulses contained within the ECG signal.

Method and apparatus for enhancing growth characteristics of seeds using ion-electron avalanches

A method and apparatus for treating seeds with self-organized avalanches of electrons between electrodes (11, 12) as a cathode and an anode with seeds (13) between the anode and cathode or on the anode. Apparatus circuit (200) in a box (20) provides simultaneous DC and AC between the electrodes which creates the avalanche of electrons which project into the seeds. The seeds must be stored before planting. The seeds so treated have enhanced growth characteristics.

Gelation coating process for boards for electronic circuits

A seat arrangement

A seat arrangement comprises first and second seat parts, each seat part having an inner face bounded at least partially by an edge surface, and at least one inner face being provided with heating means which when activated causes the at least one inner face to transmit heat therefrom. The first and second seat parts are connected together for relative movement between an open state and a closed state, wherein when in the open state the edge surfaces of the first and second seat parts are apart from one another and the at least one inner face is arranged to transmit heat out from the seat arrangement and when in the closed state, the edge surfaces of the first and second seat parts are in proximity to one another with the respective inner faces facing one another, to mitigate heat loss from the seat arrangement.

Resolving genome fractions using polymorphism counts

Method for preserving porosity in porous materials

ABSTRACT A dimensionally-stable, non-collapsible highly porous foam based upon an insoluble protein-based polymeric material, is produced by forming a liquid dispersion of an insoluble protein-based polymeric material which does not flow under elevated tempera-tures, quickly freezing the dispersion to form frozen liquid particles, subliming the frozen liquid particles to produce a highly porous foam, and subjecting the highly porous foam to elevated temperature and vacuum conditions sufficient to stabilize the highly porous foam so that its porosity is preserved when it is contacted with a liquid solution of a chemical cross-linking agent. The stabilized highly porous foam is then subjected to a liquid solution of a chemical crosslinking agent so as to produce a dimensionally-stable, non-collapsible highly porous foam material.

Resolving genome fractions using polymorphism counts

Methods of reliably estimating genomic fraction (e.g., fetal fraction) from polymorphisms such as small base variations or insertions-deletions are disclosed. Sequenced data from a multigenomic source is used to determine allele counts for one or more of the polymorphisms. For one or more of the polymorphisms, zygosity is assigned, and genomic fraction is determined from the zygosity and allele counts. Certain embodiments employ SNPs as the relevant polymorphism. The disclosed methods can be applied as part of an intentional, pre-designed re-sequencing study targeted against known polymorphisms or can be used in a retrospective analysis of variations found by coincidence in overlapping sequences generated from maternal plasma (or any other setting where a mixture of DNA from several people are present).

Preparation of a metal matrix composite body by a spontaneous infiltration process

In the present improved process for producing a metal matrix composite body by spontaneous infiltration, a permeable mass or preform to be infiltrated is exposed to a source of infiltration enhance or infiltration enhance precursor which has been heated to a temperature beyond the expected infiltration temperature. Specifically, the infiltration enhance or its precursor is heated to a temperature at which its vapor pressure is at least 100 millitorr or at least 100 °C greater than the temperature at which subsequent infiltration will occur. This temporary temperature excursion permits the concentration of infiltration enhance or its precursor to more rapidly increase within the permeable mass or preform, thereby more quickly permitting spontaneous infiltration to initiate and proceed.

Dual plate friction clutch

A dual plate friction clutch has opposed hydraulic cylinders (16,17) and a single interposed reaction plate (13). The plate (13) is driven by a plurality of cylindrical pins (25) extending between the housings of the cylinders (16,17) and passing through apertures of the plate (13). Pressure plates (26) are provided between each cylinder and a respective driven member of the clutch, the plates (26) also being driven by the pins. One or more pins (25) may be hollow to provide a fluid feed duct to one of the hydraulic cylinders.

Method and apparatus for classifying video data

A method of classifying video data representing activity within a space to be monitored. A method comprises storing video data obtained from a camera configured to monitor the space. Sensor data indicative of a condition occurring within the space is obtained, and a plurality of programme elements are defined within the video data. Each programme element has an associated classification code, and each classification code is selected using the sensor data.

Multilayer membrane useful as synthetic skin

ABSTRACT OF THE DISCLOSURE A multilayer membrane, which is useful as synthetic skin, is disclosed herein. A first layer is formed from a material which does not provoke an immune response and which is also insoluble and nondegradable in the presence of body fluids and/or body enzymes. Preferred materials for the first layer are crosslinked composites of collagen and a mucopolysaccharide. A second layer is formed from a nontoxic material which controls the moisture flux of the overall membrane to about 0.1 to 1 mg./cm2/hr. Suitable materials for the second layer includes syn-thetic polymers such as silicone resins, polyacrylate or poly-methacrylate esters or their copolymers, and polyurethanes.

Lift mechanism for framing nailer

A driving mechanism for use in a fastener driving tool, said driving mechanism comprising: (a) a guide body that receives a fastener that is to be driven from an exit end of said driving mechanism; (b) a movable driver actuation device; (c) an elongated driver member that is in mechanical communication with said movable driver actuation device at a first end of said driver member, said driver member having a second, opposite end that is sized and shaped to push a fastener from said exit end of the driving mechanism, said driver member having a direction of movement between a first end travel location and a second end travel location, said driver member having a first contacting surface between said first end and said second end, said driver member having a ready position proximal to one of said first end travel location and said second end travel location; and wherein: (d) a lift mechanism which includes a movable arm that exhibits a proximal end and a distal end, said proximal end being in communication with said guide body and said distal end having a lifter subassembly mounted thereto, said lifter subassembly including a second contacting surface, said movable arm being movable between a first position and a second position, said movable arm being biased toward said first position, said movable arm having a mechanical freedom of movement toward said second position, and if said movable arm is in said first position, said second contacting surface of the lifter subassembly is in an engagement position with respect to said first contacting surface of the driver member; (e) wherein: (i) during a lifting stroke, said second contacting surface of the lifter subassembly attempts to contact said first contacting surface of the driver member and thus cause said driver member to move to said ready position; (ii) during said lifting stroke, if said driver member and said lifter subassembly are misaligned, such that said first contact surface cannot be properly contacted by ...