15-08-2019 дата публикации
Номер: US20190247342A1
Принадлежит:
Disclosed herein are methods and compositions for treating, inhibiting, or reducing hair loss, treating, inhibiting, or reducing pigmentation loss, improving or stimulating hair growth, and/or improving or stimulating pigmentation production in a subject with one or more alpha-ketobutyrate compounds and/or one or more glutarate compounds. 1. A method for treating , inhibiting , or reducing hair loss; improving or stimulating hair growth; treating , inhibiting , or reducing pigmentation loss; and/or improving or stimulating pigmentation production in a subject which comprises administering to the subject a therapeutically effective amount of one or more alpha-ketobutyrate compounds and/or one or more glutarate compounds.2. The method according to claim 1 , wherein the one or more alpha-ketobutyrate compounds is alpha-ketobutyrate (α-KB) claim 1 , the one or more glutarate compounds is alpha-ketoglutarate (α-KG) claim 1 , and/or the one or more glutarate compounds is 2-hydroxypentanedioate (2-HG).5. The composition according to claim 4 , wherein Ris{'sup': '7', '(a) hydrogen, —CHO, or —OR;'}{'sup': 7', '7, '(b) —OR, wherein Ris hydrogen, substituted or unsubstituted alkyl, or substituted or unsubstituted aryl; or'}{'sup': 7', '7, 'sub': '1-20', '(c) —OR, wherein Ris Csubstituted or unsubstituted alkyl.'}6. The composition according to claim 4 , wherein{'sup': 2', '8', '9', '8', '9, '(a) Ris hydrogen, halogen, —CN, —CHO, or —NRR, wherein Rand Rare each independently hydrogen or substituted or unsubstituted alkyl; or'}{'sup': 2', '3, '(b) Rand R, together with the atom to which they are bound, form an oxo.'}7. The composition according to claim 4 , wherein R claim 4 , R claim 4 , and Rare each independently hydrogen claim 4 , —CHO claim 4 , —OR claim 4 , —NRR claim 4 , —COOR claim 4 , or —CONRR claim 4 , wherein R claim 4 , R claim 4 , and Rare each independently hydrogen or Csubstituted or unsubstituted alkyl.8. The composition according to claim 4 , wherein Ris — ...
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