13-10-2016 дата публикации
Номер: US20160296660A1
Принадлежит:
Compositions that include nanoscale structured materials or precursors thereof (e.g., self: assembling peptides) are described. The compositions can include other substances (e.g., a vasoconstrictor). Also described are methods for using the compositions to promote hemostasis, to protect the skin or wounds from contamination, to decontaiminate a site upon removal of previously applied compositions that provided a protective coating, and to inhibit the movement of bodily substances other than blood. The compositions are also useful in isolating tissue, removing tissue, preserving tissue (for, e.g., subsequent transplantation or reattachment), and as bulking, stabilizing or hydrating agents. Medical devices that include the compositions (e.g., a stent or catheter), bandages or other wound dressings, sutures, and kits that include the compositions are also described. 127-. (canceled)28. A formulation for preventing or inhibiting the movement of bodily fluids and contaminants , comprising self-assembling peptides of from 8 to 200 amino acids in length , inclusive , wherein the self-assembling peptides consist of two or more contiguous motifs of from 4 to 16 amino acid residues conforming to one or more of Formulas I-IV , independently:{'br': None, 'sup': neu', '+', 'neu', '−, 'sub': x', 'y', 'n, '((Xaa-Xaa)(Xaa-Xaa))\u2003\u2003(I)'}{'br': None, 'sup': neu', '−', 'neu', '+, 'sub': x', 'y', 'n, '((Xaa-Xaa)(Xaa-Xaa))\u2003\u2003(II)'}{'br': None, 'sup': +', 'neu', '−', 'neu, 'sub': x', 'y', 'n, '((Xaa-Xaa)(Xaa-Xaa))\u2003\u2003(III)'}{'br': None, 'sup': −', 'neu', '+', 'neu, 'sub': x', 'y', 'n, '((Xaa-Xaa)(Xaa-Xaa))\u2003\u2003(IV)'}{'sup': neu', '+', '−, 'wherein Xaais alanine, valine, glycine, isoleucine, phenylalanine, tyrosine or leucine; Xaa is arginine, lysine or ornithine; Xaa is aspartic acid or glutamic acid; x and y are integers having a value of 1 or 2, or 4, independently; and n is an integer having a value of 1-4,'}with or without one additional amino acid ...
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