16-05-2013 дата публикации
Номер: US20130123237A1
Автор:
Rajan Anand,
James M. Apgar,
Tesfaye Biftu,
Ping Chen,
Lin Chu,
Vincent J. Colandrea,
Guizhen Dong,
James F. Dropinski,
Danqing Feng,
Jacqueline D. Hicks,
Jinlong Jiang,
Alexander J. Kim,
Kenneth J. Leavitt,
Bing Li,
Xiaoxia Qian,
Iyassu Sebhat,
Lan Wei,
Robert R. Wilkening,
Zhicai Wu
Novel compounds of structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension. 2. The compound according to wherein:{'sup': '3', 'T is selected from the group consisting of: CR, N and N-oxide;'}{'sup': '1', 'U is selected from the group consisting of: CR, N and N-oxide;'}{'sup': '2', 'V is selected from the group consisting of: CR, N and N-oxide;'}{'sup': '4', 'W is selected from the group consisting of: CR, N and N-oxide,'}provided that at least one of T, U, V and W is N or N-oxide; [{'sub': '2', '(1) —CH—,'}, '(2) —CHF—,', {'sub': '2', '(3) —CF—,'}, '(4) —S—,', '(5) —O—,', {'sub': '2', '(6) —O—CH—,'}, '(7) —NH—,', '(8) —C(O)—,', '(9) —NHC(O)—,', '(10) —C(O)NH—,', {'sub': '2', '(11) —NHSO—,'}, {'sub': '2', '(12) —SONH—, and'}, {'sub': '2', '(13) —CO—,'}], 'X is absent or selected from{'sub': 2', '2', '1-6', '2', '2', '1-6', '1-6', '2', '1-6', '2', '2', '1-6', '1-6', '2, 'wherein each CHis unsubstituted or substituted with 1 or 2 substituents selected from: hydroxy, halogen, NH, Calkyl, COH, COCalkyl, COCalkyl, phenyl and —CH-phenyl, and wherein each NH is unsubstituted or substituted with 1 substituent selected from: Calkyl, COH, COCalkyl, COCalkyl, phenyl and —CH-phenyl;'} [{'sub': '3-10', '(1) Ccycloalkyl,'}, {'sub': '3-10', '(2) Ccycloalkenyl,'}, {'sub': '2-10', '(3) Ccycloheteroalkyl,'}, {'sub': '2-10', '(4) Ccycloheteroalkenyl,'}, '(5) aryl, and', '(6) heteroaryl,, 'Y is selected from{'sup': 'b', 'wherein cycloalkyl, cycloalkenyl, cycloheteroalkyl, cycloheteroalkenyl, aryl and heteroaryl are unsubstituted or substituted with 1, 2, 3 or 4 substituents selected from R;'} (1) oxo,', '(2) —CN,', {'sub': '3', '(3) —CF,'}, {'sub': '1-6', '(4) —Calkyl,'}, {'sub': 2', 't, '(5) —(CH)- ...
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