Energieeffiziente Luftstromsteuerung

Ein Luftführungs-Steuerungssystem beinhaltet Ablufteinheiten eines Gebäudeluftführungs-Managementsystems. Jede der Ablufteinheiten beinhaltet eine Steuereinheit und einen ersten Sensor zum Steuern von Funktionen ihrer jeweiligen Ablufteinheit. Ein zweiter Sensor ermittelt eine Gebläsedrehzahl eines Zuluftgebläses. Ein verbundener Computer empfängt benutzerausgewählte Einstellungen zum Steuern des Betriebs der Ablufteinheiten, erfasst Daten von den Steuereinheiten über entsprechende erste Sensoren und von den zweiten Sensoren, wendet die Daten auf die Einstellungen an und ändert den Betrieb des Systems über eine Steuereinheit von mindestens einer der Ablufteinheiten nach Bedarf.

SKALIERBARES MULTI-DIE-SYSTEM FÜR TIEFENLERNEN

Ein verteiltes tiefes neuronales Netz (DNN) verwendet eine verteilte, kachelbasierte Architektur, welche auf einer Halbleiter-Baueinheit implementiert ist. Die Baueinheit weist mehrere Chips auf, welche jeweils ein zentrales Verarbeitungselement, einen globalen Speicherpuffer und Verarbeitungselemente aufweist. Jedes Verarbeitungselement weist einen Gewichtspuffer, einen Aktivierungspuffer und Multiplikations-Akkumulations-Einheiten auf, um parallel die Gewichtswerte und die Aktivierungswerte zu kombinieren.

Process for improving the catalytic activity of catalyst systems for reductive amination of aliphatic cyanoaldehydes to aliphatic diamines

The instant invention provides a process for improving catalytic activity of catalyst systems for reductive amination of aliphatic cyanoaldehydes to aliphatic diamines. The process for improving catalytic activity of catalyst systems for reductive amination of aliphatic cyanoaldehydes to aliphatic diamines comprises the steps of: (1) feeding ammonia, optionally hydrogen, and optionally one or more solvents over one or more heterogeneous metal based catalyst systems having a reduced catalytic activity for a period of greater than 1 hour at a temperature in the range of from 50° C. to 500° C.; wherein said one or more heterogeneous metal based catalyst systems have a yield of less than 90 percent based on the molar conversion of cyanoaldehydes to diamines; and (2) thereby improving the catalytic activity of said one or more heterogeneous metal based catalyst systems.

Methods and apparatus related to gate boundaries within a data space

In one embodiment, one or more processor-readable media storing code representing instructions that when executed by one or more processors cause the one or more processors to receive a set of parameter values defining a boundary within a data space associated with a dataset. The dataset can represent signaling related to a test substance. A first metric can be defined based on a first portion of the dataset associated with a first region defined by the boundary. A second metric can be defined based on a second portion of the dataset associated with a second region defined by the boundary after the boundary is modified. The second region can be different than the first region.

Reusable ultrasonic medical devices and methods of their use

A variety of methods for managing a re-usable ultrasonic medical device may include a medical device control module capable of receiving functional data from a user assembled or reassembled ultrasonic medical device, and notifying the user if a value of the functional data lies within an acceptance range. If the value of the functional data does not lie within the acceptance range, the control module may prompt a user to reassemble the device or to clean or replace one or more components thereof. The functional data may relate to a clamp force of a jaw assembly, an impedance or resonant frequency value of an ultrasonic blade, or a mechanical displacement value of one or more moving components of the device.

Design layouts for connecting contacts with metal tabs or vias

The present disclosure relates to methodologies for designing semiconductor structures, and, more particularly, creating a methodology to connect contacts of semiconductor elements to a metal line using marker tabs to reserve space for future connections between the contacts and the metal line, and then reassigning the marker tabs to connections between the contacts and the metal line on different levels of a metal stack formed over the semiconductor elements.

Downhole transducer assemblies and pressure range control therein

A downhole transducer assembly capable of being safely operated at a variety of pressures and depths may include a turbine rotatable by a fluid pressure differential rotationally fixed to a rotor in a generator. To reduce the rotational speed of the turbine and rotor, a pressure regulator may limit a fluid pressure differential by controlling the volumetric flow. One or more nozzles may be configured to automatically regulate a nozzle diameter, and therefore the pressure drop across the nozzle. A surge protector may be connected to the generator.

Immunoassays for differential detection of clostridium difficile

Ultrasensitive and quantitative assays for detecting toxins of Clostridium difficile , which may involve digital ELISA, are provided. Also provided herein are differential detection assays that allow for distinguishing toxin B of highly virulent Clostridium difficile strains from toxin B of less virulent strains.

Immobilized product tolerant microorganisms

Methods for adapting or selecting microorganisms with increased product tolerance are provided. Additionally, a bioreactor capable of operation in either packed bed or fluidized bed is disclosed along with methods to use the bioreactor for culturing microorganisms adapted or selected increased product tolerance.

Strategic pausing for quantum state leakage mitigation

Systems and techniques that facilitate strategic pausing for quantum state leakage mitigation are provided. In various embodiments, a system can comprise a detection component that can detect a quantum state leakage associated with one or more qubits. In various aspects, the system can further comprise a pause component that can, in response to detecting the quantum state leakage, generate a time pause prior to execution of a quantum circuit on the one or more qubits. In various embodiments, the pause component can generate the time pause after execution of a previous quantum circuit on the one or more qubits, where the quantum state leakage arises during the execution of the previous quantum circuit. In some cases, the quantum state leakage can decay during the time pause.

Automated diagnostic analyzers having vertically arranged carousels and related methods

Example automated diagnostic analyzers and methods for using the same are disclosed herein. An example apparatus described herein includes a first carousel rotatably coupled to a base and having a first axis of rotation. The example apparatus includes a second carousel rotatably coupled to the base and vertically spaced over the first carousel such that at least a portion of the second carousel is disposed over the first carousel. In the example apparatus, the second carousel has a second axis of rotation and a plurality of vessels. The example apparatus also includes a pipetting mechanism offset from the second axis of rotation. The example pipetting mechanism is to access the first carousel and the second carousel.

Materials and methods for detection and quantification of beta-n-methylamino-l-alanine

Provided herein are isotopically labeled reagents, including isotopically labeled small molecules and peptides, that can be used to detect and/or quantify β-N-methylamino-L-alanine (BMAA) in a sample. The reagents can be used as stable isotope labeled standards in analytical methods, including in conjunction with mass spectrometry, to detect and/or quantify BMAA in a sample, such as a protein sample from a subject.

Surgical instrument with variable clamping force

An ultrasonic instrument includes a body and a shaft assembly extending distally from the body. The shaft assembly includes an acoustic waveguide. The instrument further includes an end effector including an ultrasonic blade. The ultrasonic blade is in acoustic communication with the acoustic waveguide. The instrument further includes a sensor configured to sense at least one characteristic of the shaft assembly and/or the end effector. The end effector is configured to be activated at varying power levels based on the at least one characteristic sensed by the sensor.

Cached result use through quantum gate rewrite

Techniques facilitating cached result use through quantum gate rewrite are provided. In one example, a computer-implemented method comprises converting, by a device operatively coupled to a processor, an input quantum circuit to a normalized form, resulting in a normalized quantum circuit; detecting, by the device, a match between the normalized quantum circuit and a cached quantum circuit among a set of cached quantum circuits; and providing, by the device, a cached run result of the cached quantum circuit based on the detecting.

Novel benzopyran compounds, compositions and uses thereof

Benzopyran compounds with strong anti-estrogenic activity and essentially no estrogenic activity are provided, which are OP-1038, which is 3-(4-hydroxyphenyl)-4-methyl-2-(4-{2-[(3R)-3-methylpyrrolidin-1-yl]ethoxy}phenyl)-2H-chromen-7-ol, and OP-1074, which is (2S)-3-(4-hydroxyphenyl)-4-methyl-2-(4-{2-[(3R)-3-methylpyrrolidin-1-yl]ethoxy}phenyl)-2H-chromen-7-ol. OP-1074 is a pure anti-estrogen when tested in the agonist mode and a complete anti-estrogen when tested in the antagonist mode. These compounds are useful for the treatment or prevention of a variety of conditions that are modulated through the estrogen receptor in mammals including humans.

Electronic Device With Antenna Feed Bolt

An electronic device may have metal structures such as metal electronic device housing structures and other conductive structures. The conductive structures may have a slot or other opening. An antenna may be formed from the conductive structures. Control circuitry in the electronic device may receive input from input-output devices and may use the input-output devices to provide a user with output. The control circuitry may be coupled to a radio-frequency transceiver that is used to transmit and receive wireless communications. The radio-frequency transceiver may be coupled to the antenna using a transmission line. The transmission line may have a radio-frequency connector that is coupled to a radio-frequency connector on an antenna feed bolt. The antenna feed bolt may have a shaft that spans the opening in the conductive structures and may be coupled to antenna feed terminals on opposing sides of the opening. The antenna may have a tuning bolt.

Surgical instrument with variable clamping force

An ultrasonic instrument includes a body and a shaft assembly extending distally from the body. The shaft assembly includes an acoustic waveguide. The instrument further includes an end effector including an ultrasonic blade. The ultrasonic blade is in acoustic communication with the acoustic waveguide. The instrument further includes a sensor configured to sense at least one characteristic of the shaft assembly and/or the end effector. The end effector is configured to be activated at varying power levels based on the at least one characteristic sensed by the sensor.

Machines systems and methods for making random fiber webs

Methods and systems of forming a random fiber web using pneumatic fiber feeding system are disclosed. The method can optionally comprise: providing a plurality of moveable apparatuses including a lickerin and a feeder, the lickerin configured to remove a plurality of fibers from a fibrous mat delivered to adjacent the lickerin by the feeder; doffing the plurality of fibers from the lickerin at a doffing location within the system; communicating an air supply to entrain the plurality of fibers with the air supply after the doffing; and collecting the plurality of fibers from the air supply to form the random fiber web.

Digital bridge pcr

The present disclosure, among other things, provides methodologies for quantifying targets of interest in samples by 1) capturing single target entities on individual solid phase particles in a manner that permits that those particles that contain captured targets to be optically distinguished from those that do not, and 2) optically analyzing the particles so that those with captured target entities are “counted”. In some embodiments, provided methods and compositions in the present application comprise a population of particles including one or more sub-populations distinguishable from one another.

Insertion device

Embodiments relate to an insertion device that includes: a plunger coupled with a lock collar. The insertion device houses contents including: a striker including self-locking striker snap arm(s) where the striker is kept from firing by a striker spring captured between the plunger and the striker when the insertion device is in a cocked position; a sensor assembly; and a needle carrier that holds a piercing member, the needle carrier captured between the striker and a needle carrier spring where a self-releasing snap(s) keeps the needle carrier cocked, where the plunger prevents the self-releasing snap(s) from repositioning and releasing the needle carrier. The striker fires the needle carrier such that the self-locking striker snap arm(s) are positioned to allow the striker to snap down. The needle carrier is then retracted when the user releases the plunger and the piercing member is encapsulated within the insertion device.

Analyte sensor with indicators

A simple sensing device includes a case with one or more indicators to indicate levels of an analyte such as glucose. The sensing device for self-monitoring an analyte includes a single, flexible case adapted to adhere to a skin of a patient. It also includes a printed circuit board assembly inside the case. It further includes a first sensor extending from the flexible case and electrically coupled to the printed circuit board, and one or more indicators in the flexible case, where the indicator(s) are adapted to indicate whether a level of an analyte is within a normal range.

Analyte sensor

A simple, disposable sensing device for sensing an analyte is housed in a single case. The sensing device can transmit sensor data to monitoring device(s). The sensing device includes: a case having a lower major wall adapted to be mounted against a patient's skin, and an upper opposing major wall; a sensor extending from the case and having a distal end sensitive to the analyte to produce an electrical signal, and a proximal end within the case having electrical contacts; a printed circuit board assembly within the case supported by one of the major walls to receive the electrical signal via the electrical contacts; and an elastomeric pad disposed in the case and biased by the other major wall to urge the proximal end of the sensor into contact with the printed circuit board assembly and maintain an electrical connection between the electrical contacts and the printed circuit board assembly.

Bottom Layer Mount for USB Connector

In embodiments, a USB connector may include a plurality of pins on a front surface and a plurality of pins on a top surface. The pins may be oriented and positioned on the USB connector such that the USB connector may be mounted to the bottom layer of a PCB. Corresponding pins of the USB connector may be conductively connected and may be mated with corresponding pins of the PCB.

TETRAHYDRO-1H-PYRIDO [3,4-b]INDOLE ANTI-ESTROGENIC DRUGS

The present disclosure provides tetrahydro-1H-pyrido[3,4-b]indole compounds or a pharmaceutically acceptable salt, solvate, hydrate, prodrug, stereoisomer, tautomer, rotamer, N-oxide and/or substituted derivative or, optionally in a pharmaceutical composition, for the modulation of disorders mediated by estrogen, or other disorders as more fully described herein.

Anti-estrogenic compounds

The present disclosure provides a compound of Formula I: or a pharmaceutically acceptable salt wherein X, R 1 -R 8 , Y 1 -Y 5 , m, n, p, and q are defined herein. The novel 2H-chromene compounds are useful for the modulation of disorders mediated by estrogen, and other disorders, as described herein. The present invention also relates to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions.

Integrated Biorefinery

Systems and methods for producing bioproducts are shown. The systems and methods herein can be configured and used in an integrated biorefinery. The integrated biorefinery may comprise a sugar production facility such as a sugar mill, a production facility for one or more bioproduct(s) such as butanol, and optionally an ethanol production facility employing the system and method.

Photovoltaic panel

Modular photovoltaic (PV) panel, system, and method of mounting. The system including a mounting flashing configured to mounted to a mounting surface and a folding PV panel. The folding PV panel including: a first subpanel including first PV cells, wherein the first subpanel extends along a first lateral plane and comprises a plurality of mounting hooks extending laterally from and affixed to a backside of the first subpanel, the mounting hooks configured to couple to the mounting flashing; a second subpanel including second PV cells, wherein the second subpanel extends along a second lateral plane, wherein the second subpanel comprises a front edge support configured to hold a front edge of the second subpanel away from the mounting surface; and a hinge assembly rotationally coupling the first subpanel and the second subpanel to allow an angle between the first lateral plane and the second lateral plane to change.

data analysis for an implantable restriction device and data logger

ANáLISE DE DADOS PARA UM DISPOSITIVO DE RESTRIçãO IMPLANTáVEL E REGISTRADOR CRONOLóGICO DE DADOS. A presente invenção refere-se a um dispositivo de restrição implantável que pode ser configurado para prover uma restrição em um paciente, por exemplo, como uma função da pressão do fluido. O dispositivo de restrição implantável pode incluir um ou mais sensores configurados para sentir uma variedade de parâmetros, tais como pressão do fluido dentro do dispositivo de restrição implantável, largura de pulso, amplitude de pulso, contagem de pulso, duração de pulso ou frequência, características elétricas ou outros parâmetros. Os dados obtidos por um ou mais sensores (por exemplo, os dados representando pressão, características de pulso e assim por diante) podem ser comunicados para um dispositivo localizado externo ao paciente, tal como um registrador cronológico de dados, usando bobinas de telemetria ou outros comunicadores. O registrador cronológico de dados pode armazenar os dados e pode comunicar os dados para uma localização remota através de uma rede, tal como a lnternet. Uma estação de encaixe pode ser provida para acoplar o registrador cronológico de dados em uma rede e/ou para recarregar uma célula no registrador cronológico de dados. Os dados registrados podem ser analisados e/ou exibidos usando uma variedade de técnicas para avaliar e/ou acompanhar a condição do dispositivo de restrição ou do paciente, para monitorar a fisiologia do paciente ou para outras finalidades. DATA ANALYSIS FOR AN IMPLANTABLE RESTRICTION DEVICE AND CHRONOLOGICAL DATA RECORDER. The present invention relates to an implantable restraint device that can be configured to provide a restraint on a patient, for example as a function of fluid pressure. The implantable restraint device may include one or more sensors configured to sense a variety of parameters, such as fluid pressure within the implantable restraint device, pulse width, pulse amplitude, pulse count, pulse duration or frequency, ...

graphical user interface (gui) with trend analysis for an implantable restraint device and chronological data logger

INTERFACE GRáFICA DE USUáRIO (GUI) COM ANáLISE DE TENDêNCIA PARA UM DISPOSITIVO DE RESTRIçãO IMPLANTáVEL E REGISTRADOR CRONOLóGICO DE DADOS. A presente invenção refere-se a um dispositivo de restrição impíantável que pode ser configurado para prover uma restrição em um paciente, por exemplo, como uma função da pressão do fluido. O dispositivo de restrição implantável pode incluir um ou mais sensores configurados para sentir uma variedade de parâmetros, tais como pressão do fluido dentro do dispositivo de restrição implantável, largura de pulso, amplitude de pulso, contagem de pulso, duração de pulso ou frequência, características elétricas ou outros parâmetros. Os dados obtidos pelo um ou mais sensores (por exemplo, os dados representando pressão, características de pulso e assim por diante) podem ser comunicados para um dispositivo localizado externo ao paciente, tal como um registrador cronológico de dados, usando bobinas de telemetria ou outros comunicadores. O registrador cronológico de dados pode armazenar os dados e pode comunicar os dados para uma localização remota através de uma rede, tal como a lnternet. Uma estação de encaixe pode ser provida para acoplar o registrador cronológico de dados em uma rede e/ou para recarregar uma célula no registrador cronológico de dados. Os dados registrados podem ser analisados e/ou exibidos usando uma variedade de técnicas para avaliar e/ou acompanhar a condição do dispositivo de restrição ou do paciente, para monitorar a fisiologia do paciente ou para outras finalidades. GRAPHIC USER INTERFACE (GUI) WITH TREND ANALYSIS FOR AN IMPLANTABLE RESTRICTION DEVICE AND CHRONOLOGICAL DATA RECORDER. The present invention relates to an unimpeachable restriction device that can be configured to provide a restriction on a patient, for example as a function of fluid pressure. The implantable restraint device may include one or more sensors configured to sense a variety of parameters, such as fluid pressure within the implantable ...

External mechanical pressure sensor for measuring gastric band pressure

physiological parameter analysis for an implantable restraint device and a chronological data logger

ANáLISE DE PARáMETRO FISIOLóGICO PARA UM DISPOSITIVO DE RESTRIçãO IMPLANTáVEL E UM REGISTRADOR CRONOLóGICO DE DADOS. A presente invenção refere-se a um dispositivo de restrição implantável que pode ser configurado de modo a proporcionar uma restrição em um paciente, por exemplo, como uma função da pressão do fluido. O dispositivo de restrição implantável pode incluir um ou mais sensores configurados para captarem uma variedade de parâmetros, tais como pressão do fluido no interior do dispositivo de restrição implantável, largura de pulsos, amplitude de pulsos, contagem de pulsos, duração de pulsos, ou freqúência, características elétricas, ou outros parâmetros. Os dados obtidos através de um ou mais sensores (por exemplo, os dados que representam a pressão, as características de pulso, e assim por diante) podem ser comunicados a um dispositivo localizado externamente em relação ao paciente, tal como um coletor de dados, que utiliza bobinas de telemetria ou outros comunicadores. O coletor de dados pode armazenar os dados, e pode comunicá-los a um local remoto através de uma rede, tal como a lnternet. Pode-se proporcionar uma estação de ancoragem com a finalidade de acoplar o coletor de dados a uma rede e/ou recarregar uma célula no coletor de dados. Os dados coletados podem ser analisados e/ou exibidos utilizando-se uma variedade de técnicas para avaliar e/ou rastrear a condição do dispositivo de restrição ou dopaciente, monitorar a fisiologia do paciente, ou para outros propósitos. PHYSIOLOGICAL PARAMETER ANALYSIS FOR AN IMPLANTABLE RESTRICTION DEVICE AND A CHRONOLOGICAL DATA RECORDER. The present invention relates to an implantable restraint device that can be configured to provide a restraint on a patient, for example as a function of fluid pressure. The implantable restraint may include one or more sensors configured to capture a variety of parameters, such as fluid pressure within the implantable restraint, pulse width, pulse amplitude, pulse count, pulse ...

gastric restriction device data handling methods and devices

MéTODOS E DISPOSITIVOS DE MANUSEIO DE DADOS DE DISPOSITIVO DE RESTRIçãO GáSTRICA. A presente invenção refere-se a métodos e dispositivos para manipular dados em um sistema de restrição implantável. Em geral, os métodos e os dispositivos permitem a coleta, a análise, o armazenamento, e a transmissão de medições de pressão. Os dados de medição de pressão podem ser comprimidos antes do armazenamento dos mesmos. Adicionalmente, nem todos os dados de pressão precisam ser registrados ou retidos, tais como os dados que são substancialmente iguais a uma pressão de repouso ou nominal de um dispositivo de restrição implantável indicativos de pouca a nenhuma variação de pressão e dados indicativos de eventos não recorrentes isolados. Quaisquer dados de medição de pressão que são registrados podem ser transmitidos a um dispositivo externo usando energia telemetri-camente provida pelo dispositivo externo. METHODS AND GASTRIC RESTRICTION DEVICE DATA HANDLING DEVICES. The present invention relates to methods and devices for manipulating data in an implantable restraint system. In general, methods and devices allow the collection, analysis, storage, and transmission of pressure measurements. Pressure measurement data may be compressed prior to storage. Additionally, not all pressure data need to be recorded or retained, such as data that is substantially equal to a resting or nominal pressure of an implantable restraint device indicative of little to no pressure variation and data indicative of non-recurring events. isolated. Any pressure measurement data that is recorded may be transmitted to an external device using power telemetically provided by the external device.

methods and devices for measuring impedance in a gastric restriction system

MéTODOS E DISPOSITIVOS PARA MEDIR IMPEDáNCIA EM UM SISTEMA DE RESTRIçãO GáSTRICA. A presente invenção refere-se a métodos e dispositivos que são fornecidos para coletar dados de impedância relacionados com os dispositivos de restrição implantáveis. Em geral, os métodos e dispositivos podem permitir que os pacientes, os profissionais de saúde e outros utilizem os dados coletados como um mecanismo de retorno para monitorar de forma nãoinvasiva a eficácia de um dispositivo de restrição implantável em um paciente e para identificar, modificar e/ou prescrever um plano de tratamento para o paciente considerando os dados coletados. Os dados de impedância podem ser coletados e analisados para o tecido próximo ao dispositivo de restrição, por exemplo, uma área de gordura entre uma faixa gástrica e o estómago do paciente. Os eletrodos em contato com o tecido podem medir uma impedância do tecido, com a impedância entre os eletrodos mudando à medida que o tecido reduz de tamanho (por exemplo, à medida que as células adiposas encolhem) e/ou muda de configuração. METHODS AND DEVICES FOR MEASURING IMPEDANCE IN A GASTRIC RESTRICTION SYSTEM. The present invention relates to methods and devices that are provided for collecting impedance data related to implantable restraint devices. In general, methods and devices may allow patients, healthcare professionals and others to use the data collected as a feedback mechanism to non-invasively monitor the effectiveness of a patient implantable restraint device and to identify, modify and / or prescribe a treatment plan for the patient considering the collected data. Impedance data can be collected and analyzed for tissue near the restraint device, for example, an area of fat between a gastric strip and the patient's stomach. Electrodes in contact with tissue may measure a tissue impedance, with the impedance between the electrodes changing as the tissue shrinks (for example, as fat cells shrink) and / or changes in configuration.

sensor trigger

DISPARADOR DE SENSOR. Métodos e dispositivos para efetuar um sistema de restrição gástrico são descritos. Em uma modalidade exemplar, um sistema de restrição para formar uma restrição em um paciente é fornecido e pode incluir um dispositivo de restrição implantável e pelo menos um sensor implantável que está em comunicação com o dispositivo de restrição. Em geral, o dispositivo de restrição implantável pode ser ajustável e pode ser configurado para formar uma restrição em um paciente. O sensor(es) implantável pode ser padrão em um modo de uso de energia inoperante e pode-ler um mecanismo de disparo que é configurado para colocar o sensor(es) em uma configuração de uso na ocorrência de um evento de disparo. SENSOR TRIGGER. Methods and devices for performing a gastric restriction system are described. In an exemplary embodiment, a restraint system for forming a restraint on a patient is provided and may include an implantable restraint device and at least one implantable sensor that is in communication with the restraint device. In general, the implantable restraint device may be adjustable and may be configured to form a restraint on a patient. The implantable sensor (s) may be standard in an inoperative power use mode and may read a trigger mechanism that is configured to place the sensor (s) in a use configuration upon the occurrence of a trigger event.

energization of implantable restraint systems using kinetic motion

ENERGIZAçãO DE SISTEMAS DE RESTRIçãO IMPLANTáVEL USANDO MOVIMENTO CINéTICO. Trata-se de vários dispositivos de energização para transferir e/ou gerar energia de várias fontes para um membro de comunicação implantado em um paciente. A energia transferida para ou gerada pelo membro de comunicação pode ser usada para proporcionar energia para um sistema de restrição implantável configurado para formar uma restrição em um trajeto. ENERGIZATION OF IMPLANTABLE RESTRICTION SYSTEMS USING KINETIC MOVEMENT. These are various energizing devices for transferring and / or generating power from various sources to a communication member implanted in a patient. Power transferred to or generated by the communication member may be used to provide power to an implantable restraint system configured to form a restraint on a path.

Automatically adjusting band system

range adjustment system automatically

A presente invenção refere-se à descrição de dispositivos e métodos para formar uma restrição em um paciente. Em uma modalidade exemplificativa, é proporcionado um sistema de restrição incluindo um dispositivo de restrição implantável, um orifício implantável em comunicação fluida com o dispositivo de restrição implantável, e uma bomba implantávei em comunicação fluida com o dispositivo de restrição. Em geral, o dispositivo de restrição implantável é ajustável e configurado para formar uma restrição em um paciente, e o orifício implantável está configurado para receber fluido de uma fonte de fluido externa para o paciente. A bomba implantável é dotada de uma pluralidade de acionadores para mudar a forma durante a aplicação de energia nos mesmos de maneira que a ativação sequencial da pluralidade de acionadores seja eficaz para criar ação de bombeamento para mover fluido através da bomba. The present invention relates to the description of devices and methods for forming a restriction in a patient. In an exemplary embodiment, a restraint system is provided including an implantable restraint device, an implantable hole in fluid communication with the implantable restraint device, and an implantable pump in fluid communication with the restraint device. In general, the implantable restraint device is adjustable and configured to form a constraint on a patient, and the implantable port is configured to receive fluid from an external fluid source to the patient. The implantable pump is provided with a plurality of actuators to change shape during energy application therein so that sequential activation of the plurality of actuators is effective to create pumping action to move fluid through the pump.

Automatically adjusting band system with mems pump

Reusable ultrasonic medical devices and methods of their use

A variety of methods for managing a re-usable ultrasonic medical device may include a medical device control module capable of receiving functional data from a user assembled or reassembled ultrasonic medical device, and notifying the user if a value of the functional data lies within an acceptance range. If the value of the functional data does not lie within the acceptance range, the control module may prompt a user to reassemble the device or to clean or replace one or more components thereof. The functional data may relate to a clamp force of a jaw assembly, an impedance or resonant frequency value of an ultrasonic blade, or a mechanical displacement value of one or more moving components of the device.

Methods and systems related to highly sensitive assays and delivering capture objects

Methods and systems for capture object-based assays, including for determining a measure of the concentration of an analyte molecule or particle in a fluid sample, are described. The methods and systems may relate to high sensitivity detection of analytes, sometimes using assay conditions and sample handling that result in the capture and detection of a high percentage of the analyte molecules or particles in a fluid sample using relatively few capture objects. Apparatuses and methods for immobilizing capture objects with respect to assay sites, in some instances with unexpectedly high efficiencies are also described. Some such apparatuses involve the use of force fields and fluid meniscus forces, alone or in combination, to facilitate or improve capture object immobilization. Also described are techniques for utilizing a relatively high percentage of capture objects in an assay sample, such as by using disclosed sample washing techniques, imaging systems, and analysis procedures that can reduce capture object loss.

Method of performing a process for determining an item of interest in a sample

Embodiments described herein provide methods of performing a process for determining an item of interest in a sample. In one embodiment, a container for holding the sample is accepted in a process lane where a process step is selectively automatically performed on the sample in the container. The process step is selectively automatically performed on the sample in the container. An effective length of the process lane is maintained constant while a physical length of the process lane is selectively varied.

Method for determination of item of interest in a sample

The embodiments disclosed relate to determination of an item of interest in a sample. In one method, a process path comprising a process lane including a process step performance lane where a process step is performed, and a process step avoidance lane where the process step is avoided is provided. A container holding the sample is moved along the process path. The sample is introduced to the container. A reagent is introduced to the container. The sample and the reagent are mixed in the container. The container is selectively positioned in a selected one of the process step performance lane and the process step avoidance lane. The item of interest in the sample is determined based upon a reaction between the sample and the reagent.

Structure for determination of item of interest in a sample

The embodiments disclosed relate to determination of an item of interest in a sample. One embodiment relates to a structure which comprises a process path. The process path comprises a process lane including a process step performance lane where a process step is performed, and a process step avoidance lane where the process step is avoided. A first prime mover is operatively connected with the process path for moving a container holding the sample along the process path. A first pipetting system is operatively associated with the process path for introducing the sample to the container. A second pipetting system is operatively associated with the process path for introducing a reagent to the container. A device is operatively connected with the process path and is selectively engagable with the container for mixing the sample and the reagent in the container. A second prime mover is operatively connected with the process path for selectively positioning the container in a selected one of the process step performance lane and the process step avoidance lane. A reader is operatively connected with the process path for determining the item of interest in the sample based upon a reaction between the sample and the reagent.

Automated diagnostic analyzers having rear accessible track systems and related methods

Example apparatus and methods related to automated diagnostic analyzers having rear accessible track systems. An example apparatus disclosed herein includes an analyzer to perform a diagnostic test, the analyzer having a first side and a second side opposite the first side. The example apparatus includes a loading bay disposed on the first side of the analyzer to receive a first carrier and a pipetting mechanism coupled to the analyzer adjacent the second side. The example apparatus also includes a first carrier shuttle to transport the first carrier from a first location adjacent the loading bay to a second location adjacent the pipetting mechanism and a track disposed adjacent the second side of the analyzer to transfer a second carrier to a third location adjacent the pipetting mechanism.

Automated diagnostic analyzers having vertically arranged carousels and related methods

Example automated diagnostic analyzers and methods for using the same are disclosed herein. An example apparatus described herein includes a first carousel rotatably coupled to a base and having a first axis of rotation. The example apparatus includes a second carousel rotatably coupled to the base and vertically spaced over the first carousel such that at least a portion of the second carousel is disposed over the first carousel. In the example apparatus, the second carousel has a second axis of rotation and a plurality of vessels. The example apparatus also includes a pipetting mechanism offset from the second axis of rotation. The example pipetting mechanism is to access the first carousel and the second carousel.

Diagnostic analyzers with pretreatment carousels and related methods

Diagnostic analyzers with pretreatment carousels and related methods are disclosed. An example apparatus includes a first carousel that includes a first annular array of slots to receive a first vessel. The example first carousel also includes a first track of rotation about the first carousel having a first diameter and a second track of rotation about the first carousel having a second diameter smaller than the first diameter. The example apparatus includes a first diverter to move the first vessel from the first track to the second track. In addition, the example apparatus includes a second carousel coaxial with the first carousel. The example second carousel includes a second annular array of slots to receive a second vessel.

Automated diagnostic analyzers having rear accessible track systems and related methods

Example apparatus and methods related to automated diagnostic analyzers having rear accessible track systems are described herein. An example apparatus disclosed herein includes an analyzer to perform a diagnostic test. The analyzer has a first side and a second side opposite the first side. The example apparatus includes a loading bay disposed on the first side of the analyzer to receive a first carrier and a pipetting mechanism coupled to the analyzer adjacent the second side. The example apparatus also includes a first carrier shuttle to transport the first carrier from a first location adjacent the loading bay to a second location adjacent the pipetting mechanism and a track disposed adjacent the second side of the analyzer to transfer a second carrier to a third location adjacent the pipetting mechanism.

Automated diagnostic analyzers having rear accessible track systems and related methods

Example apparatus and methods related to automated diagnostic analyzers having rear accessible track systems. An example apparatus disclosed herein includes an analyzer to perform a diagnostic test, the analyzer having a first side and a second side opposite the first side. The example apparatus includes a loading bay disposed on the first side of the analyzer to receive a first carrier and a pipetting mechanism coupled to the analyzer adjacent the second side. The example apparatus also includes a first carrier shuttle to transport the first carrier from a first location adjacent the loading bay to a second location adjacent the pipetting mechanism and a track disposed adjacent the second side of the analyzer to transfer a second carrier to a third location adjacent the pipetting mechanism.

Diagnostic analyzers with pretreatment carousels and related methods

Diagnostic analyzers with pretreatment carousels and related methods are disclosed. An example apparatus includes a first carousel that includes a first annular array of slots to receive a first vessel. The example first carousel also includes a first track of rotation about the first carousel having a first diameter and a second track of rotation about the first carousel having a second diameter smaller than the first diameter. The example apparatus includes a first diverter to move the first vessel from the first track to the second track. In addition, the example apparatus includes a second carousel coaxial with the first carousel. The example second carousel includes a second annular array of slots to receive a second vessel.

Automated diagnostic analyzers having vertically arranged carousels and related methods

Example automated diagnostic analyzers and methods for using the same are disclosed herein. An example apparatus described herein includes a first carousel rotatably coupled to a base and having a first axis of rotation. The example apparatus includes a second carousel rotatably coupled to the base and vertically spaced over the first carousel such that at least a portion of the second carousel is disposed over the first carousel. In the example apparatus, the second carousel has a second axis of rotation and a plurality of vessels. The example apparatus also includes a pipetting mechanism offset from the second axis of rotation. The example pipetting mechanism is to access the first carousel and the second carousel.

Automated diagnostic analyzers having vertically arranged carousels and related methods

Example automated diagnostic analyzers and methods for using the same are disclosed herein. An example apparatus described herein includes a first carousel rotatably coupled to a base and having a first axis of rotation. The example apparatus includes a second carousel rotatably coupled to the base and vertically spaced over the first carousel such that at least a portion of the second carousel is disposed over the first carousel. In the example apparatus, the second carousel has a second axis of rotation and a plurality of vessels. The example apparatus also includes a pipetting mechanism offset from the second axis of rotation. The example pipetting mechanism is to access the first carousel and the second carousel.

Substituted benzopyran compounds, compositions and uses thereof

Benzopyran compounds with anti-estrogenic activity are provided as Formula I, II, III, IV, V, VI, VII, VIII, IX, X, XI, XII, XIII, XIV, XV, XVI, XVII and XVIII. These compounds are useful for the treatment or prevention of a variety of conditions that are modulated through the estrogen receptor in mammals including humans.

Ultra-sensitive detection of molecules or particles using beads or other capture objects

The present invention relates to systems and methods for detecting analyte molecules or particles in a fluid sample and in some cases, determining a measure of the concentration of the molecules or particles in the fluid sample. Methods of the present invention may comprise immobilizing a plurality of analyte molecules or particles with respect to a plurality of capture objects. At least a portion of the plurality of capture objects may be spatially separated into a plurality of locations. A measure of the concentration of analyte molecules in a fluid sample may be determined, at least in part, on the number of reaction vessels comprising an analyte molecule immobilized with respect to a capture object. In some cases, the assay may additionally comprise steps including binding ligands, precursor labeling agents, and/or enzymatic components.

Methods for extending dynamic range in assays for the detection of molecules or particles

Systems, devices, and methods for ultra-sensitive detection of molecules or particles

Described are systems, devices, and methods which related to various aspects of assays for detecting and/or determining a measure of the concentration of analyte molecules or particles in a sample fluid. In some cases, the systems employ an assay consumable comprising a plurality of assay sites. The systems, devices, and/or methods, in some cases, are automated. In some cases, the systems, devices, and/or methods relate to inserting a plurality of beads into assay sites, sealing assay sites, imaging assay sites, or the like.

Detection of DNA or RNA using single molecule arrays and other techniques

Described herein are methods and systems for detecting DNA or RNA using single molecules array or other techniques. DNA or RNA from the sample may be fragmented and exposed to a first type of binding ligand and a second type of binding ligand that comprise nucleic acid sequences complimentary at least a portion of a sequence contained in the target DNA or RNA. At least a portion of the fragmented DNA or RNA associates with at least one of the first type of binding ligand and/or the second type of binding ligand, wherein the first type of binding ligand and second type of binding ligand comprises nucleic acid sequences complimentary to a different portions of a sequence contained in the DNA or RNA. A portion of the sample exposed to the binding ligands is analyzed to determine the number of fragmented DNA or RNA sequences.

Concentric camshaft phaser torsion drive mechanism

Variable Nockensteuerungsbaugruppe (10) und Verfahren für einen Verbrennungsmotor eines Kraftfahrzeugs, die einen Nockenwellenversteller (22) aufweist, der zwischen einer inneren Nockenwelle (12a) und einer äußeren Nockenwelle (12b) einer konzentrischen Nockenwelle (12) verbunden ist. Ein Torsionsantriebsmechanismus (14) verbindet zwischen dem Nockenwellenversteller (22) und der inneren Nockenwelle (12a), um Drehmoment zu übertragen. Der Torsionsantriebsmechanismus (14) erlaubt das Justieren der lotrechten Stellung und axialen Fluchtungsabweichung der inneren und äußeren Nockenwelle (12a, 12b), während eine drehsteife Kupplung zwischen dem Nockenwellenversteller (22) und der inneren oder äußeren Nockenwelle (12a, 12b) der konzentrischen Nockenwelle (12) aufrechterhalten wird. Der Torsionsantriebsmechanismus (14) kann entweder aus einer flexiblen Wellenkupplung (40), einem quer geteilten angetriebenen Rad (140), einem quer geteilten Zahnhohlrad (240), einem Querstirnverzahnungsrad (340) oder einem Stift- und Schlitzkombinationsantrieb (440) ausgebildet sein. A variable cam timing assembly (10) and method for an internal combustion engine of a motor vehicle having a phaser (22) connected between an inner camshaft (12a) and an outer camshaft (12b) of a concentric camshaft (12). A torsion drive mechanism (14) connects between the phaser (22) and the inner camshaft (12a) to transmit torque. The torsion drive mechanism (14) allows adjustment of the vertical position and axial misalignment of the inner and outer camshafts (12a, 12b), while a torsionally rigid coupling between the camshaft adjuster (22) and the inner or outer camshaft (12a, 12b) of the concentric camshaft ( 12) is maintained. The torsion drive mechanism (14) may be formed from either a flexible shaft coupling (40), a split split driven wheel (140), a split toothed ring gear (240), a crosshead gear (340), or a pin and slot combination drive (440).

Process for preparing aryl trifluoromethylsulfides

Trifluoromethylthiocopper, formed in situ by the reaction of bis-(trifluoromethylthio)mercury with copper, reacts with aromatic bromides and iodides to give aryl trifluoromethyl sulfides.

Antibody conjugates

There is disclosed an antibody and antibody-drug conjugate for targeting drug delivery as well as a class of chemicals, termed a drug-binding molecule of complementary structure (csDBM). The csDBM is designed to "fit" the drug by combining multiple non-covalent interactions between functional groups on the drug and opposing functional groups on the csDBM. The net result on the antibody-csDBM-drug conjugate is a drug stably bound to the csDBM so as not to dissociate during in vivo administration, but not so tightly bound to allow drug dissociation from the conjugate without significant loss of activity and retaining the drug's ability to bind to a higher affinity site on or within the target cell.

Cleavable linkers for the reduction of non-target organ retention of immunoconjugates

A process for reducing the non-target organ accumulation of immunoconjugates administered in vivo during therapeutic or diagnostic procedures involves the use of immunoconjugates comprising linkers that are cleavable at the non-target organs. The linkers are cleavable under conditions present, or induced, at one or more non-target organs, which include the kidneys or the liver.

Unsaturated heterocyclic derivatives

This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.

Camshaft incorporating variable camshaft timing phaser rotor

In a VCT system, the rotor of a phaser is integral to a shaft such as a camshaft. The lobes on the camshaft are also integral to the camshaft. The axial dimension and the radial dimension of the resultant rotor-cam shaft-cam lobes combination are reduced.

Production and use of multimeric hemoglobins

Multimeric hemoglobin-like proteins are obtained by crosslinking cysteines of the component tetramers, or by genetically fusing globin-like domains of one tetramer with those of another, by means of an interdomain spacer sequence. Artificial cysteines are introduced selectively in a single globin-like domain per tetramer to control polymerization.

Production and use of multimeric hemoglobins

DNA molecules which encode pseudodimeric globin-like polypeptides with an asymmetric cysteine mutation suitable for crosslinking two tetramers, or which encode pseudooligomeric globin-like polypeptides comprising four or more globin-like domains, are useful in the preparation of multimeric hemoglobin-like proteins.

surgical cutting and fixation instrument with rf electrodes

INSTRUMENTO CIRúRGICO DE CORTE E FIXAçãO DOTADO DE ELETRODOS DE RF. A presente invenção refere-se a um instrumento cirúrgico de corte e fixação. O instrumento compreende um manípulo e um atuador final conectado ao manípulo, O atuador final compreende elementos de garra opostos superior e inferior, sendo que o elemento de garra superior compreende uma pluralidade de eletrodos de RF colineares, separadamente atuáveis. SURGICAL INSTRUMENT FOR GETTING AND FASTENING OF RF ELECTRODES. The present invention relates to a surgical cutting and clamping instrument. The instrument comprises a handle and a final actuator connected to the handle. The final actuator comprises opposing upper and lower gripper elements, the upper gripper element comprising a plurality of separately actuatable collinear RF electrodes.

Process for preparing perfluoromethacrylyl fluoride

Copolymers of perfluoromethacrylyl fluoride

Polymerization of ethylene oxide using metal cyanide catalysts

Compuestos heterociclicos biciclicos.

La invención se refiere a compuestos de la fórmula general (I): (ver fórmula (I)) en la que los grupos variables son como se definen aquí, y a su preparación y uso.

Bicyclic heteroaryl compounds

This invention relates to compounds of the general formula (I) in which the variable groups are as defined herein, and to their preparation and use.

Acetylenic heteroaryl compounds

This invention relates to compounds of the general formula (I):in which the variable groups are as defined herein, and to their preparation and use.

Monocyclic heteroaryl compounds

This invention relates to compounds of the general formula(I) in which the variable groups are as defined herein, and to their preparation and use.

アンビルを有する改良された電気外科止血装置

(57)【要約】 【課題】 組織を破ることなく血液などの凝固を行なう ことができ、種々の止血用途に適用することができるア ンビルを有する改良された電気外科止血装置を提供す る。 【解決手段】 特に内視鏡的手術の際に、様々なインピ ーダンス、厚さ、脈管分布の組織を焼灼および／又は融 合するための電気外科装置を提供する。この装置は１つ の相互接続面に配置された二極エネルギーソースの１極 と、所定範囲で圧力をかける第２相互接続面との間で組 織を圧縮する。本装置では相互接続面の１つが規定前荷 重とばね率を有するアンビルに配置される。第２極は２ つの相互接続面の一方に配置される。好ましい実施形態 では、第１極と絶縁体が２極を電気的に分離するので第 ２極は同じ相互接続面に配置される。本発明の好ましい 用途は止血ラインがＲＦエネルギーを使用してカットラ インに沿って形成される切断装置である。

Removal of inhibitors of microbial fermentation from inhibitor-containing compositions

Methods are provided for conditioning an inhibitor-containing composition, such as a cellulosic biomass hydrolysate, to remove inhibitors of microbial growth and/or product production. The methods include precipitation of inhibitors by formation of complexes with metal salts, such as aluminum sulfate and ferric chloride.

Process for preparing linearly-extended polyalkylenepolyamines

A process for preparing linearly-extended polyalkylenepolyamines, such as linear and branched polyethylenepolyamines, comprising contacting a difunctional aliphatic alcohol, such as monoethanolamine, with a reactant amine, such as ethylenediamine, in the presence of a catalyst containing tungsten oxide essentially free of the metals of Groups VIII, IB, and IIB of the Periodic Table. Included among the linearly-extended polyalkylenepolyamines are alcohol-extended piperazines, such as N-(2-hydroxyethyl)-piperazine, and amine-extended piperazines, such as N-(2-aminoethyl)piperazine.

Preparation of alkyl-extended, alcohol-extended or amine-extended piperazines

A process for preparing alkyl-extended, alcohol-extended or amine-extended piperazines or mixtures thereof comprising contacting a difunctional aliphatic alcohol with a reactant amine, wherein at least one of the aliphatic alcohol or the reactant amine contains a piperazine moiety, in the presence of a catalyst containing a Group VB metal oxide or a Group VB metal phosphate, or mixtures thereof. For example, monoethanolamine reacts with piperazine in the presence of a catalyst of niobic acid supported on hydrated alumina to yield predominantly N-(2-aminoethyl)piperazine. Also, N-hydroxyethylpiperazine reacts with piperazine in the presence of a catalyst of niobium phosphate to yield predominantly 1,2-bis(piperazinyl)ethane.

Catalytic reforming of alkyleneamines

A process of reforming an alkyleneamine feedstock or a mixture of such feedstocks to an alkyleneamine or a mixture of alkyleneamines which is different from the feedstock or feedstock mixture. The process is catalyzed by one of the following: Group VB metal oxides, Group VB metal phosphates, Group IIA metal silicates, and tungsten oxides. For example, ethylenediamine is contacted with a catalyst of niobic acid or magnesium silicate to yield predominantly diethylenetriamine and non-cyclic triethylenetetramines; whereas high molecular weight polyethylenepolyamines are cracked by the same catalysts to mixtures of lower molecular weight linear and cyclic materials.

Catalytic reforming of cyclic alkyleneamines

A process of reforming cyclic alkyleneamines to amine-extended cyclic alkyleneamines involving contacting a cyclic alkyleneamine or mixture of cyclic alkyleneamines in the liquid phase with a catalyst under reaction conditions. The catalyst is selected from the group consisting of (a) Group VB metal oxides, (b) Group VB metal phosphates, (c) silicates of Groups IIA, IIIB, IVB and VB, and (d) specified tungsten oxides. For example, piperazine or a mixture of piperazine and aminoethylpiperazine is contacted with magnesium silicate to yield a mixture of amine-extended piperazines, including 1,2-bis(piperazinyl)-ethane and N,N'-bis(2-piperazinylethyl)piperazine.

Packaging film, packages and methods for using them

Polyolefin polymerization process, method of producing catalyst, and catalyst

A process for preparing a polymerization catalyst useful for the polymerization of olefins is provided comprising contacting a metal dihalide compound wherein the metal is selected from Group 2 and Group 12 of the Periodic Table and a transition metal compound which is a hydrocarbyloxide of a transition metal selected from Group 4 and Group 5 to form a first catalyst component; contacting the first catalyst component with at least one organoaluminum precipitating agent, wherein at least at the commencement of this step, the temperature at which such contacting is carried out is greater than about 70° C. to about 150° C. to form a solid product, and contacting the solid product with an activating agent to form a catalyst. Other aspects of the invention provide a catalyst prepared by the above described method and a polymerization process employing the thus prepared catalyst.

Biaxially oriented polyethylene films

Articulating radio frequency (RF) tissue seal with articulating state sensing

A surgical instrument is presented that may include a handle assembly, a shaft assembly, an end effector and an articulation joint coupled to the shaft assembly and the end effector. The surgical instrument also may include an articulation control mechanism configured to: control movement of the articulation joint between a first and second maximum articulation angle; determine that the articulation joint has articulated to the first maximum articulation angle; provide a first indication that the articulation joint has articulated to the first maximum articulation angle; determine that the articulation joint has articulated to the second maximum articulation angle; and provide a second indication that the articulation joint has articulated to the second maximum articulation angle.

Medical sensor with modulated encoding scheme

The present invention provides an encoding mechanism for a medical sensor which uses a modulated signal to provide the coded data to a remote analyzer. The modulated signal could be, for instance, a pulse width modulated signal or a frequency modulated signal. This signal is amplitude independent and thus provides a significant amount of noise immunity.

Pouched through the washer and dryer laundry additive product having at least one wall comprised of finely apertured polymeric film

A pouched through the washer and dryer laundry additive product having at least one of its walls constructed of finely apertured polymeric film. In a particularly preferred embodiment, both pouch walls are constructed of finely apertured polymeric film to permit substantially full dissolution and discharge of the washer additive contained in the pouch during the washing cycle, yet retain substantially all of the dryer additive until the product is transferred into an automatic clothes dryer along with the laundered textiles. Pouched through the washer and dryer laundry additive products of the present invention deliver a significantly greater quantity of dryer additive material onto the textiles being tumble dried when contrasted with comparably constructed pouches comprised entirely of nonwoven and/or paper material. Furthermore, pouched through the washer and dryer laundry additive products of the present invention accomplish the aforementioned objective without an accompanying increase in staining of the textiles by the dryer added materials. Subcombination dryer additive products which contain no washer additive, but which are capable of withstanding a wash cycle without adversely affecting their performance in the dryer are also disclosed.

Devices and methods for the performance of miniaturized homogeneous assays

This invention relates to methods and apparatus for performing microanalytic and microsynthetic analyzes and procedures. The invention provides a microsystem platform and a micromanipulation device for manipulating the platform that utilizes the centripetal force resulting from rotation of the platform to motivate fluid movement through microchannels. These assays may be performed for a variety of purposes, including but not limited to screening of drug candidate compounds, life sciences research, and clinical and molecular diagnostics. Methods specific for the apparatus of the invention for performing any of a wide variety of microanalytical or microsynthetic processes are provided.

Method and system for secure computer moderated voting

A method and system is provided for improved electronic voting. The system optionally allows paper type ballots to be utilized. A plurality of cryptographic routines are utilized in a distributed data processing system to maximize the privacy of both the voter's identity and the content of completed ballots. An authentication server is utilized to interact with a voter to issue electronic ballots and receive completed electronic ballots in a manner which determines the authenticity of the identification of the voter, while maintaining the content of the completed ballot confidential. The distributed data processing system further includes a results server which tabulates the content of completed ballots in a manner which maintains the identity of the voters associated with the particular ballots confidential. The distributed data processing system may further include a journal server which records completed ballots, in a manner which facilitates the challenge of ineligible votes and the correction of erroneous votes.

Immobilized product tolerant microorganisms

Methods for adapting or selecting microorganisms with increased product tolerance are provided Additionally, a bioreactor capable of operation in either packed bed or fluidized bed is disclosed along with methods to use the bioreactor for cultu~ng microorganisms adapted or selected increased product tolerance

Integrated system and process for bioproduct production

Processes and systems for production of bioproducts such as biofuels are provided. The bioproduct production processes and systems utilize pretreatment of a carbohydrate-containing feedstock to produce soluble sugar molecules and continuous conversion of the pretreated feedstock to a bioproduct by an immobilized fermenting microorganism.

Alkyl perfluoro-ω-fluoroformyl esters and their preparation

Alkyl perfluoro- omega -fluoroformyl esters are provided which have the formula: <IMAGE> wherein R is alkyl of 1-6 carbon atoms, and n is 0-6 (preferably 0).

Nanostructure coating materials and methods of use thereof

Nanostructured coating materials, methods of their production, and methods of use in a variety of applications are described. The nanostructured materials described herein include one or more 2+ and/or 3+ metal ion(s), optionally in a ternary phase, on a substrate.

Ultrasonic surgical blade

An ultrasonic instrument comprises an ultrasonic transducer, an acoustic waveguide, and an ultrasonic blade. The blade includes a pair of obliquely extending edges. The obliquely extending edges diverge away from the longitudinal axis of the waveguide and away from each other along respective paths extending distally in relation to the waveguide. A distal portion of the blade is wider than a proximal portion of the blade along a plane. The blade further includes a curved distal edge and several laterally presented surfaces. The laterally presented surfaces may provide combinations of concave and convex curvatures. The laterally presented surfaces may be angled and/or curved along one or more orthogonal planes associated with the longitudinal axis of the waveguide.

Surgical instrument with variable clamping force

An ultrasonic instrument includes a body and a shaft assembly extending distally from the body. The shaft assembly includes an acoustic waveguide. The instrument further includes an end effector including an ultrasonic blade. The ultrasonic blade is in acoustic communication with the acoustic waveguide. The instrument further includes a sensor configured to sense at least one characteristic of the shaft assembly and/or the end effector. The end effector is configured to be activated at varying power levels based on the at least one characteristic sensed by the sensor.

Surgical instrument with variable clamping force

An ultrasonic instrument includes a body and a shaft assembly extending distally from the body. The shaft assembly includes an acoustic waveguide. The instrument further includes an end effector including an ultrasonic blade. The ultrasonic blade is in acoustic communication with the acoustic waveguide. The instrument further includes a sensor configured to sense at least one characteristic of the shaft assembly and/or the end effector. The end effector is configured to be activated at varying power levels based on the at least one characteristic sensed by the sensor.

Ultrasonic surgical blade

An ultrasonic instrument comprises an ultrasonic transducer, an acoustic waveguide, and an ultrasonic blade. The blade includes a pair of obliquely extending edges. The obliquely extending edges diverge away from the longitudinal axis of the waveguide and away from each other along respective paths extending distally in relation to the waveguide. A distal portion of the blade is wider than a proximal portion of the blade along a plane. The blade further includes a curved distal edge and several laterally presented surfaces. The laterally presented surfaces may provide combinations of concave and convex curvatures. The laterally presented surfaces may be angled and/or curved along one or more orthogonal planes associated with the longitudinal axis of the waveguide.

Ultrasonic surgical blade

An ultrasonic instrument comprises an ultrasonic transducer, an acoustic waveguide, and an ultrasonic blade. The blade includes a pair of obliquely extending edges. The obliquely extending edges diverge away from the longitudinal axis of the waveguide and away from each other along respective paths extending distally in relation to the waveguide. A distal portion of the blade is wider than a proximal portion of the blade along a plane. The blade further includes a curved distal edge and several laterally presented surfaces. The laterally presented surfaces may provide combinations of concave and convex curvatures. The laterally presented surfaces may be angled and/or curved along one or more orthogonal planes associated with the longitudinal axis of the waveguide.

Sensor set

A sensor set is provided for sensing of a body characteristic, such as glucose. The sensor set includes a mounting base for the sensor and a connector to connect to the mounting base and has an improved structure for connecting the mounting base to the connector. The connector may contain sensor electronics for wired or wireless communication to an external monitor or display. The mounting base includes latch arms and the connector adapted to fit and lock into latch recesses on the connector and includes anti-rotation arms adapted to fit into anti-rotation arm recesses on the connector.

Sensor and transmitter product

A medical sensor device includes a sensor assembly including an underside surface for attachment against a patient's skin, a sensor portion to detect a characteristic of the patient, and sensor assembly contacts which in operation carry signals representing the detected characteristic. The device also includes a transmitter assembly removably engageable with the sensor assembly and including circuitry to take the signals from the sensor assembly contacts and to transmit readings of the detected characteristic to external equipment. The device also includes mechanical interface components on the sensor assembly and the transmitter assembly which allow the transmitter assembly to be brought into abutment with the sensor assembly at a first angular position via relative axial movement between them, and then allow a relative rotation of the assemblies with respect to one another towards a second angular position and presents axial separation of the assemblies in the second angular position.

Analyte sensor

A simple, disposable sensing device for sensing an analyte is housed in a single case. The sensing device can transmit sensor data to monitoring device(s). The sensing device includes: a case having a lower major wall adapted to be mounted against a patient's skin, and an upper opposing major wall; a sensor extending from the case and having a distal end sensitive to the analyte to produce an electrical signal, and a proximal end within the case having electrical contacts; a printed circuit board assembly within the case supported by one of the major walls to receive the electrical signal via the electrical contacts; and an elastomeric pad disposed in the case and biased by the other major wall to urge the proximal end of the sensor into contact with the printed circuit board assembly and maintain an electrical connection between the electrical contacts and the printed circuit board assembly.

Sensor and transmitter product

This disclosure generally relates to medical devices that include a transmitter assembly positioned on top of a sensor assembly. A sensor assembly includes a sensor base having a bottom surface and a top surface having an interface. The interface accommodates a sensor stack that includes at least one sensor head having electrical contact pads connected to an elastomeric connector. The sensor assembly further includes a mounting base having a first side that attaches to the bottom surface of the sensor base, and a second side that adheres to a patient's skin. A transmitter assembly includes a transmitter shell and a transmitter cap having an interface that engages with the sensor base. Also, the transmitter assembly includes electrical contacts disposed on the transmitter cap that connect with the electrical contact pad(s) of the sensor assembly.

Flexible physiological characteristic sensor assembly

A sensor introducer for a physiological characteristic sensor assembly includes a sensor introducer body that includes an outer housing that defines an opening to receive the physiological characteristic sensor assembly and an inner housing surrounded by the outer housing. The sensor introducer includes a cradle movable relative to the inner housing from a first position to a second position to deploy the physiological characteristic sensor assembly. The cradle has a cradle flange to receive the physiological characteristic sensor assembly and a cradle body that receives a needle assembly. The cradle body includes at least one locking projection that engages the inner housing to inhibit the movement of the cradle relative to the inner housing in the first position and the at least one locking projection is movable relative to the inner housing to enable the cradle to move from the first position to the second position.

Flexible physiological characteristic sensor assembly

A physiological characteristic sensor assembly includes a flexible top housing including a needle port having a central opening, and a flexible lower housing defining a sensor bore through the lower housing, the sensor bore coaxial with the central opening of the needle port. The physiological characteristic sensor assembly also includes an electrical subsystem disposed between the top housing and the lower housing. The electrical subsystem includes a flexible printed circuit board having a sensor contact pad, a physiological characteristic sensor and an electrically conductive adhesive patch. The physiological characteristic sensor has a distal end that extends through the needle port and a proximal end that includes at least one electrical contact. The conductive adhesive patch electrically and physically couples the at least one electrical contact of the physiological characteristic sensor to the sensor contact pad of the flexible printed circuit board.

Dual tensioner system for balance shaft drive

A chain tensioning system includes a pair of tensioners (202,210) located one on each side of a driving sprocket (299), such as a crankshaft sprocket, between the driving sprocket (299) and each of two driven sprockets (296,297), such as balance shaft sprockets. The dual tensioning system provides a tensioner to absorb torsional vibrations from the driving shaft (280) in each of the two relative rotational directions of the driving shaft (280).