10-05-2012 дата публикации
Номер: US20120114755A1
This document relates to methods and materials for treating tendon injury. Specifically, methods and materials for preventing adhesion formation and promoting tissue healing following tendon injury and surgical repair are provided. 1. A composition comprising a tissue matrix and an anti-adhesive coating , wherein said tissue matrix comprises stem cells and one or more structural polypeptides or one or more biocompatible polymers , and wherein said anti-adhesive coating is present on at least one surface of said tissue matrix.2. The composition of claim 1 , wherein said coating is present on at least one surface of said tissue matrix that does not contact a wound or sutured tissue when implanted in a mammal.3. The composition of claim 2 , wherein said wound or sutured tissue is tendon claim 2 , ligament claim 2 , abdominal claim 2 , uterine claim 2 , or muscle tissue.4. The composition of claim 1 , wherein said one or more structural proteins are selected from the group consisting of a collagen claim 1 , a proteoglycan claim 1 , and a cytokine claim 1 , or any combination thereof.5. The composition of claim 1 , wherein said one or more structural polypeptides are selected from the group consisting of collagen claim 1 , aggregan claim 1 , versican claim 1 , decorin claim 1 , biglycan claim 1 , fibromodulin claim 1 , lumican claim 1 , IL-1 claim 1 , IL-6 claim 1 , and TNF-α claim 1 , or any combination thereof.6. The composition of claim 1 , wherein said tissue matrix is an acellular tissue scaffold.7. The composition of claim 1 , wherein said tissue matrix is a collagen matrix.8. The composition of claim 7 , wherein said collagen matrix is a matrix of bioengineered collagen fibers.9. The composition of claim 1 , wherein said biocompatible polymer is a natural or synthetic biodegradable polymer.10. The composition of claim 1 , wherein said anti-adhesive coating is selected from the group consisting of lubricin claim 1 , hyaluronic acid claim 1 , phospholipids claim 1 , ...
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