06-03-2014 дата публикации
Номер: US20140066429A1
A compound having the structure set forth in Formula (I) and Formula (II): 3. The method of wherein Y is a heteroaryl group optionally substituted with 1 claim 1 , 2 claim 1 , or 3 R.4. The method of wherein the heteroaryl group is selected from the group consisting of furan claim 3 , pyridine claim 3 , pyrimidine claim 3 , pyrazine claim 3 , imidazole claim 3 , thiazole claim 3 , isothiazole claim 3 , pyrazole claim 3 , triazole claim 3 , pyrrole claim 3 , thiophene claim 3 , oxazole claim 3 , isoxazole claim 3 , 1 claim 3 ,2 claim 3 ,4-oxadiazole claim 3 , 1 claim 3 ,3 claim 3 ,4-oxadiazole claim 3 , 1 claim 3 ,2 claim 3 ,4-triazine claim 3 , indole claim 3 , benzothiophene claim 3 , benzoimidazole claim 3 , benzofuran claim 3 , pyridazine claim 3 , 1 claim 3 ,3 claim 3 ,5-triazine claim 3 , thienothiophene claim 3 , quinoxaline claim 3 , quinoline claim 3 , and isoquinoline; each of which is optionally substituted with 1 claim 3 , 2 claim 3 , or 3 R.5. The method of wherein the heteroaryl group is substituted with C-Calkyl selected from the group consisting of methyl claim 4 , ethyl claim 4 , n-propyl claim 4 , iso-propyl claim 4 , n-butyl claim 4 , iso-butyl claim 4 , and tert-butyl.6. The method of wherein C-Calkyl is methyl.7. The method of wherein Z is an aryl group which is optionally substituted with 1 claim 1 , 2 claim 1 , or 3 R.8. The method of wherein the aryl group is a phenyl group which is optionally substituted with 1 claim 7 , 2 claim 7 , or 3 R.9. The method of any of wherein the phenyl group is substituted with 1 claim 8 , 2 claim 8 , or 3 Rselected from the group consisting of Br claim 8 , Cl claim 8 , F claim 8 , and I.10. The method of wherein Ris F.11. The method of wherein Ris selected from the group consisting of F claim 1 , Cl claim 1 , Br claim 1 , and I.12. The method of wherein Ris F.13. The method of where the compound is selected from the group consisting of:8,9-diphenyl-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one;8,9-bis(4- ...
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