Traditional Chinese medicine composition for removing freckle and preparation method and application of traditional Chinese medicine composition

Technical Field

The invention relates to a method for removing ephelides Chinese medicinal composition and preparation method and application thereof, belongs to the technical field of cosmetics.

Background Art

Ephelides is a mainly occur in the brown spots of the skin of the face. Have a genetic tendency, in about 5 years in left and right, it is gradually increased along with the age growth, it was commonly found in female, good sends in face, in particular to nose and cheek. Rash gingili the size of the spot, presenting brown or dark brown , circular or irregularly-shaped, normally a plurality of symmetrically distributed over the face, the neck may also occur, and the forearm back of the exposed parts of the legs, and the like, of different sizes, number diophantine, sparse of from several to several hundred of the intensive. Without any subjective feeling, but ephelides obstruct cosmetic, more and more people of various means of removing ephelides.

Modern medical view, the disease is the dominant heredity euchromosome, accept fluorescent in the long-wave ultraviolet radiation, the melanin in the epidermis body can rapidly become oxidized, to deepen the color of the skin rash, the shape becomes larger, the increase in the number of. Daylight lamp will also increase the skin rash, that is, exposed to the sunlight in the occurrence of this disease is a skin rash factors necessary. Therefore, in the daily life, people of the freckle should be noted that fluorescent of excessive heat is reduced.

The commonly used method of removal of a chemical method, a laser method and microdermabrasion method, a laser method is apt to cause skin mottling and pigmentation, and the cost is relatively high, microdermabrasion method is difficult to control if the depth of the penetration is deep will enter subcutaneouse cause permanent scar, chemical method is a commonly used, but chemical endoarterectomy the possible chemical cracking-off medicinal preparation through the skin caused by absorption of the whole body toxicity reaction, and after a long time of repairing skin.

Chinese medicine theory that the, freckle generated by the inherent cause of congenital or acquired wind in wet and heat caused by the attack of the kidney of the two losses. "All pathogenic period of five days theory feudal LORDS · body disease" states said addressed in :" menstrual blood twelve body, on the surface of all, ioof blood trip table ju Rong , or the edema diseases soak the internal organs , or membrane principle wind , electroluminescent and Qi, either astringent or muddy , cannot rong Yu skin, the Peutz. " That this expositions ephelides Chinese medicine (ephelides) mainly due to the loss of kidney essence, blood-meridian fire Yu Yu , water deficit cannot governs the fire , evil wind outside wrestles for sclerostachya. This is the so-called kidney insufficient water, rong Yu surface can not be on, the virtual fire stagnates the bloodin stagnates the bodyspot or element shared blood heat, breach of evil wind, and the blood heat sun Luocommon cold wrestles anti- in , cannot rong Run skin, the freckle.

Ephelides patient's concomitant endocrine disorders, metabolic waste in the body to form a spot deposited on the surface, plus in daily life, the strong sunlight ultraviolet irradiation, causing melanophages deposition, generating and deepen. The pace of modern life, many people are in a kind of Asian healthy state, so in the daily life of lead to endocrine there are many reasons for this. For example, the mood of the liver due to fluctuating quickly shall not normal, caused by the formula of the stagnation, hepaticojejunostomy metabolism function is not normal or ovarian function will occur also when spot Sichuan , this is also one of the reasons for the endocrine disorder. If the long-term is under the state of pressure, the balance of the metabolism of the human body can be damaged, people experience secretome adrenergic, skin the required nutrient supply tends to be slow, pigment mother cells will become very active, freckle and then produced. The law of diet, the physical and psychological pressure large, sleep and rest time confusion in a certain extent will be also caused by endocrine disorders.

In order to effectively adjust the balance of the human body, are good for the, purpose of treating the sample, thus very good removing ephelides, the invention relates to blood opens raises , the principle of activating dispels dry , adding Chinese herbal medicine through the extracting component, and the continuous, smooth to ischemia, viscera holds makes up , make the endocrine metabolic balanced, the removing of the freckle.

Content of the invention

The purpose of this invention is to provide a method for removing ephelides Chinese medicinal composition and its preparation method, the used for getting rid of traditional Chinese medicine composition of the freckle removing ephelides remarkable curative effect, high safety, adverse reaction is extremely small, can be widely applied to the cosmetics or medicines in.

The technical scheme of the invention

For removing Chinese medicinal composition of the freckle, raw materials used for preparing the same composition and the content are as follows:

Windproof   20-30g

Poria (Indian bread)   10-20g

Japanese knotweed   40-50g

west safflower   10-20g

Gorgon euryale   10-20g

Fructus Ligustri Lucidi   20-30g

Herba Taraxaci (taraxacum, dandelion)   20-30g

Fructus cnidii   10-20g

Rhizoma seu radix Notopterygii   10-20g

Unused   20-30g

Cirrhifolium   20-30g

COiX seed   20-30g

Chinese tamarisk   10-20g

Saltiest shrimp flower   5-15g

Semen Cuscutae   15-25g

Ivy   10-20g

Arctium Fructus Arctii (great burdock achene)   25-35g

Cimicifugae   20-30g

Arnebia   10-20g

Natural indigo   25-35g

Caulis Piperis kadsurae   10-20g

Cicadella   35-45g

red balloonflower   10-20g

rabbit hair wormwood   10-20g

Licorice   10-20g;

Preferably the raw materials used in the preparation and the content are as follows:

Windproof   20-25g

Poria (Indian bread)   10-15g

Japanese knotweed   40-45g

west safflower   10-15g

Gorgon euryale   10-15g

Fructus Ligustri Lucidi   20-25g

Herba Taraxaci (taraxacum, dandelion)   20-25g

Fructus cnidii   10-15g

Rhizoma seu radix Notopterygii   10-15g

Unused   20-25g

Cirrhifolium   25-30g

COiX seed   25g-30g

Chinese tamarisk   15-20g

Saltiest shrimp flower   10-15g

Semen Cuscutae   20g-25g

Ivy   15g-20g

Arctium Fructus Arctii (great burdock achene)   30g-35g

Cimicifugae   25-30g

Arnebia   15-20g

Natural indigo   30-35g

Caulis Piperis kadsurae   15-20g

Cicadella   40-45g

red balloonflower   15-20g

rabbit hair wormwood   15-20g

Licorice   15-20g;

More preferably the raw materials used in the preparation and the content are as follows:

Windproof   25g

Poria (Indian bread)   15g

Japanese knotweed   45g

west safflower   15g

Gorgon euryale   15g

Fructus Ligustri Lucidi   25g

Herba Taraxaci (taraxacum, dandelion)   25g

Fructus cnidii   15g

Rhizoma seu radix Notopterygii   15g

Unused   25g

Cirrhifolium   25g

COiX seed   25g

Chinese tamarisk   15g

Saltiest shrimp flower   10g

Semen Cuscutae   20g

Ivy   15g

Arctium Fructus Arctii (great burdock achene)   30g

Cimicifugae   25g

Arnebia   15g

Natural indigo   30g

Caulis Piperis kadsurae   15g

Cicadella   40g

red balloonflower   15g

rabbit hair wormwood   15g

Licorice   15g;

Said traditional Chinese medicine preparation method of extracting components specific for the crushing component are all raw materials, in accordance with the above-mentioned

Parts by weight is mixed in the boiler, and clean cold water, in order to submerge the powder shall prevail, soaking 60 minutes, then adding cold water, submerged over-powder 2-3cm, decoction, first after heating to boil with the conflagration, to use small fire, to maintain boiling to 60 minutes, after the filtrate crosses , proper amount of water, re-boil out, filtering, merging two filtrate, concentrated under reduced pressure to remove water, to obtain the dry, pulverized to 100 meshes.

The above-mentioned a used for getting rid of the freckle in cosmetics and Chinese medicine composition can be used in medicine, in order to contain only of this invention used for getting rid of a traditional Chinese medicine composition of the freckle mask as an example for description, but does not limit its in other pharmaceutical or cosmetic application.

A containing the above-mentioned is used for getting rid of a traditional Chinese medicine composition of the freckle bate stains mask, the raw material components used in the preparation and the content are as follows:

Is used for getting rid of traditional Chinese medicine composition of the freckle   2-4g

Surface active ingredient   0.4-0.6g

Glycerin   10-14g

Polyvinyl alcohol   10-14g

Lactic acid   1-2g

De-ionized water to   100g;

The surface-active agent is a fluorine-containing surface active agent;

The above method for preparing of the facial mask bate stains , specifically comprising the following steps:

In the polyvinyl alcohol is added to the deionized water, heated to the 60-70 [...] , the polyvinyl alcohol is dissolved completely, lowering the temperature to the 45-50 [...] , then adding glycerol, lactic acid uniform stirring, then cooled to the 30-35 [...] , sequentially adding the freckle used for getting rid of Chinese medicinal composition and surface active ingredient, stir, removing sclerostachya mask is obtained.

The beneficial effect of the invention

A of this invention is used for getting rid of traditional Chinese medicine composition of the freckle, the more remarkable curative effect of freckles, high safety, adverse reaction is extremely small, and can be used in the cosmetic, and does not influence the patient's daily work and study, is a safe and effective methods of treatment.

Description of drawings

Figure 1, of the two used in the present invention an infrared spectrogram amphoteric surfactant.

Mode of execution

The present invention provides a de-sclerostachya mask, its raw materials include Chinese medicine extraction component, surface active ingredient, glycerin, polyvinyl alcohol, lactic acid and deionized water.

Further preferably, only the mask states the bate stains prepared by the above-mentioned raw materials.

The facial mask states the bate stains in the weight of the various raw materials are of traditional Chinese medicine extraction component 2g-4g, surface active ingredient 0.4g -0.6g, glycerin 10g-14g, polyvinyl alcohol 10g-14g, lactic acid 1g-2g and deionized water 100 g.

Further preferably, the mask states the bate stains all raw materials in the weight of the extract ingredients into 3g, surface active ingredient 0.5g, glycerin 12g, polyvinyl alcohol 12g, lactic acid 1g and deionized water 100 g.

The invention also provides the above-mentioned dehydration sclerostachya mask preparation method, including:

1st step, the preparation of traditional Chinese medicine extraction component;

2nd step, the production of surface-active ingredient;

3rd step, according to the weight of the polyvinyl alcohol is added to the deionized water, heated to the 60-70 [...] , dissolving, lowering the temperature to the 45-50 [...] , subsequently joined glycerol, lactic acid stir, further, lowering the temperature to the 30-35 [...] , to the 1st step preparation of traditional Chinese medicine extraction component and 2nd-step preparation of the active ingredient on the surface, uniform stirring, to obtain mask.

The Chinese medicine extract ingredient includes wind-proof, Poria (Indian bread), Japanese knotweed, west carthamine, Gorgon euryale, fructus Ligustri Lucidi, Herba Taraxaci (taraxacum, dandelion), fructus cnidii, Rhizoma seu radix Notopterygii, peony bark, cirrhifolium, COiX seed, Chinese tamarisk, saltiest shrimp flower, semen Cuscutae, ivy, Arctium Fructus Arctii (great burdock achene), Cimicifugae, arnebia, natural indigo, sea breeze cane , cicadella, red balloonflower , and rabbit hair wormwood.

Further preferably, said traditional Chinese medicine only extracting composition prepared by the above-mentioned raw material.

All raw materials are the weight of the wind-proof 20g-30g, Poria (Indian bread) 10g-20g, Japanese knotweed 40g-50g, west carthamine 10g-20g, Gorgon euryale 10g-20g, fructus Ligustri Lucidi 20g-30g, Herba Taraxaci (taraxacum, dandelion) 20g-30g, fructus cnidii 10g-20g, notopterygium 10g-20g, unused 20g-30g, cirrhifolium 20g-30g, COiX seed 20g-30g, Chinese tamarisk 10g-20g, saltiest shrimp flower 5g-15g, semen Cuscutae 15g-25g, ivy 10g-20g, Arctium Fructus Arctii (great burdock achene) 25g-35g, Cimicifugae 20g-30g, arnebia 10g-20g, natural indigo 25g-35g, caulis Piperis kadsurae 10g-20g, cicadella 35g-45g, red balloonflower 10g-20g, rabbit hair wormwood 10g-20g and licorice 10g-20g.

Further preferably, the weight of the various raw materials are windproof 20g-25g, Poria (Indian bread) 10g-15g, Japanese knotweed 40g-45g, west carthamine 10g-15g, Gorgon euryale 10g-15g, fructus Ligustri Lucidi 20g-25g, Herba Taraxaci (taraxacum, dandelion) 20g-25g, fructus cnidii 10g-15g, notopterygium 10g-15g, unused 20g-25g, cirrhifolium 25g-30g, COiX seed 25g-30g, Chinese tamarisk 15g-20g, saltiest shrimp flower 10g-15g, semen Cuscutae 20g-25g, ivy 15g-20g, Arctium Fructus Arctii (great burdock achene) 30g-35g, Cimicifugae 25g-30g, arnebia 15g-20g, natural indigo 30g-35g, caulis Piperis kadsurae 15g-20g, cicadella 40g-45g, red balloonflower 15g-20g, rabbit hair wormwood 15g-20g and licorice 15g-20g.

Most preferably, the weight of the various raw materials are windproof 25g, Poria (Indian bread) 15g, Japanese knotweed 45g, west carthamine 15g, Gorgon euryale 15g, fructus Ligustri Lucidi 25g, Herba Taraxaci (taraxacum, dandelion) 25g, fructus cnidii 15g, notopterygium 15g, unused 25g, cirrhifolium 25g, COiX seed 25g, Chinese tamarisk 15g, saltiest shrimp flower 10g, semen Cuscutae 20g, ivy 15g, Arctium Fructus Arctii (great burdock achene) 30g, Cimicifugae 25g, arnebia 15g, natural indigo 30g, caulis Piperis kadsurae 15g, cicadella 40g, red balloonflower 15g, rabbit hair wormwood 15g and licorice 15 g.

Pharmacological the raw material are as follows:

Wind-proof: in, Ganong, s lightly warm nature, lung, liver, spleen, the bladder, with expelling cold exterior syndrome, dampness to relieve pain, or wind, the role of relieving itching, siloxane cold card and mainly used for closing, the retardation of the internal table of the epidermis cold.

Poria (Indian bread): sweet taste, light, mild, components, lung, bladder, sutra, with infiltrates the wet favorable water , and the role of the tranquilizing, used mainly in water wet stagnant edem, urine adverse; the pyretic stranguria wet heat accumulation, and tongue of wet sleepy , phlegm retention stagnation, and epilepsy.

Japanese knotweed:   et   Rhizoma   Cuspidati   Radix Hibernia   Polygoni, cabardine, micro-cold. turns over to the liver , corallodiscus, the lung passes through , with clearing away heat and toxic materials, the favorable gallbladder draws back yellow , wind and promoting diuresis, sterilization of blood stasis, of relieving cough, for joint arthralgia, damp-heat jaundice, menostasia, abdominal mass, a cough, scald, -cavotricuspid damage, and carbuncular swelling poisonous matter.

West Flos Carthami (safflower):   Cacumen Hibernia Tamaricis, the incidence of plant liu Kestrange willow tree drying delicate branches and leaves, sweet taste, mild nature, to, opens the knot world, relieving pain. Used for the treatment of concern and retardation, the local ruffian is stuffy upright, hematemesis, nontyphoidal mad, surprise absentminded, women menostasia, menoxenia sterilizing, post-partum lochia not do, a pain of blood stasis, measles, the traumatic injury.

Gorgon euryale: sweet taste, astringent, mild nature. Guipi, the of the kidney. Regulatingh with kidney, spleen diarrhea, with the function of dispels stops wet , for treating nocturnal emission spermatorrhoea, diarrhea spleen, spleen nebulousurine, the belt.

Fructus Ligustri Lucidi: sweet, bitter, micro-cold, liver, the kidney passes through , with strong liver profit kidney , the role of the clear, free pump mainly used for the treatment of liver and kidney, chieftain loses raises dizzy tinnitus, internal heat of the deficiency.

Herba Taraxaci (taraxacum, dandelion):   Herba Hibernia   Taraxaci, taste sweet, bitter, cold, liver, consumed, with clearing away heat and toxic materials, lumps pusdraining, administration, the role of the falls, is mainly used for the treatment of enjoyment, the obvious effect particularly acute mastitis, can also be used in the gall inflammation item of red irascibility on.

Fructus cnidii: Hibernia   fructus cnidii, pungent in taste, bitter, custom, enters the kidney to pass through , decocting dough made with boiling, drying damp insectcidal, the role of the expelling, for kidney Yang deficiency of impotence men, women's cold, cold and dampness and leukorrhagia or waist knee Leng Tong.

Rhizoma seu radix Notopterygii: pungent in taste, bitter, custom, enters the kidney , the bladder, expelling cold has, inhibit, analgesic efficacy, prima clamps wet with wind, sickness sees the chill heating, headache if binds , neck back strong pain , limb heavy, joint pain, and wind-cold.

Botan piney: cold, bitter, centering, liver, kidney, the lung passes through , have clear away heat and cool the blood, the effects of blood stasis, the heat enters the menstruation for's warm pyreticosis, made by sclerostachya, spits nosebleed , breakbone late heating hot Fu Yinfen , bone jeung hectic yin, sterilizing menostasia, dysmenorrhea, thereof medicinal powder for curing mastosis stiring, adopts the pain, rheumatism the lipoxygenase.

Cirrhifolium: sweet taste, mild, lung, spleen, the kidney passes through , it has effects of the lung, the role of the spleen Qi, lignosulfonate for yin deficiency, produce dry, to quench one's thirst multi-drinking, asthenia, the spleen is cloudy deficiency or deficiency of spleen, kidney deficiency is lost, soreness of soft, and beaf.

COiX seed: the nature is cool , sweet taste, light, Guipi, stomach, the lung passes through , toothpaste with the spleen, clearing away heat pus, removing paralysis, the function of the water, used for wonky, loose stool diarrhea, driving mover hooks one end of or women, spleen wet thanh edem, negative urine, pain or tinea pedis; wet heat arthralgia, limbs, grieved pain; pus phlegmpulmonary abscess hawk and spit , or enteralgia arrests anxiously abdominal pain.

Chinese tamarisk: Tamaricis Tamaricis of the plant the branch istender branches and leaves , flavor, kissin, mild, on lung, stomach, sutra, with wind and, exterior syndrome, passes measles , alexipharmically, to wind-heat cold, measles, impervious measles leave , rheumatism, Certificate skin pruritus, and the like.

Saltiest shrimp flower: to Compositae turtledove plants agastaches of shrimp salty, bitter, kissin, mild, with dispersing wind and heat, and promoting diuresis, the effects of swelling, can be used for the treatment of common cold heating, dysentery, megrims headache, hypertension, diarrhea, rheumatism, eczema, urticaria, furuncle, acute mastitis, traumatic injury, not sore, cassava poisoning Certificate.

Semen Cuscutae: sweet taste, kissin, mild, turns over to the liver , kidney, spleen by, kidney, a, the role of the sterilized, is mainly used for sexual impotence of a lack of kidney, weiqing prospermia, frequency of micturition, dizziness, tinnitus; too kidney deficiency, woman leukorrhagia, is not repeated; the losses, insufficient culture designated double-mesh, unclear; pond abdominal pain two virtual the spleen, etc valley not.

Ivy: pungent in taste, bitter, mild, turns over to the liver , sple, the lung passes through , with wind, and promoting diuresis, and blood, alexipharmically, can be used for the treatment of rheumatism, headache, dizziness, hepatitis, traumatic injury, sore throat, with stiring, the snake bites.

Arctium Fructus Arctii (great burdock achene): pungent in taste, bitter; cold, on lung, consumed, with the evacuation of heat, clearing away heat and detoxifying and, the efficacy of the lung the advantage swallows disperses swells , to wind-heat cold, beginning mainly; heat or lung-heat cough, unsmooth phelgm; sore throat; included impermeable; measles initial, measles leave not to be smooth and the urticarias pruritus; and MUMPs and enjoyment.

Cimicifugae: in, is sweet, flavor, lung, spleen, stomach, large intestine through, has published passes measles , clearing away heat and toxic materials, the effect of lifting pathology. For wind-heat headache, builds, Aphtha, sore throat, measles impermeable, sends the spotpositive poison ; rectocele, the uterine prolapse.

Arnebia: cold, sweet, salty, centering, liver meridian, it has effects of cooling the blood circulation, the efficacy of and detoxifying and. Is used for blood the painfully hot sun is abundant , included [...] , measles impermeable, sore, eczema, scald. refrigeration cold hearted , for measles, breakbone [...] , eczema, hematuria, stranguria with hematuria , arresting, sore, Erysipelas, burn, the constipation.

Natural indigo: squama, cold, into the liver meridian, with clearing away heat and toxic materials, cooling the blood hemostasis, fire the effects of liver, for mainly made by sclerostachya, hematemesis, sore throat, herpeticum eczema, T-heat, irascibility violates the lung , cough pectoralgia, blood in the phlegm brings , high thermal epilepsy, convulsion convulsion Certificate.

Caulis Piperis kadsurae: pungent in taste, bitter, sexual tepefaction, turns over to the liver to pass through , with rheumatism, through the channels, the efficacy of Spirulina ice cream, to wind-cold, legs pain, ache of limbs, the flexion.

Cicadella:   Folium Hibernia Isatidis, bitter, sexual dahan, centering, hepaticojejunostomy, corallodiscus, consumed, with-clearing and detoxifying, cold hearted spot , the efficacy of jaundice, not only can reality of the clear disposition is hot , but also can painfully hot sun of the solution menstruation , is mainly used for bacterial wilt breakbone the high thermal LONGAN, polydipsias directs to drink ; the relieved substituting sends the spot mad, symptoms such as blood ejection; measles according at a high temperature, purple darkmeasles color ; hepatobilliary damp-heat jaundice of aquatic plants steams ; hepatobilliary the fire rises epicophosis and sonitus of; fire sultriness toxic the pharyngalgia, sore, Certificate of hepatitis.

red balloonflower : of the Compositae Eupatorium plant different leaf arethusa japonica agastaches, sweet, bitter, sexual tepefaction, turns over to the liver , the kidney passes through , with blood tiaojinghuoxue, removing blood stasis obtunding, efficacy of water of fluid, can be used for the treatment of menoxenia, menostasia, abdominal pain, lochia not all right, edema, traumatic injury, bone fracture Certificate.

rabbit hair wormwood : of the sweetening plant linethe chrysanthemum iscompositae line agastaches, bitter, cold, with clearing away heat and toxic materials, antibacterial, anti-infectious, calms the nerves to overcome one's fears , tiaojinghuoxue anthemorrhagic efficacy of, can be used for the treatment of infectious diseases high heat, heartbeat, insomnia, neurasthenia, menorrhagia, and menoxenia.

Licorice:   et   Rhizoma   Radix Hibernia   Glycyrrhizae, sweet taste, mild nature, into the twelve through, a clearing away heat and toxic materials, drug, the role of the sputum cough, spleen and in and, pain, mainly used for anorexia of abdominal distension of asthenia, hypodynamia; abdomen pain contraction can be relieved, easing fulminating and toxicity of certain drugs, the drugs or toxic side effect of the organism irritation to the gastrointestinal tract, by adding the licorice can play a massflow neutralization, reconcile made of each component.

Said traditional Chinese medicine preparation method of extracting components specific for the crushing component are all raw materials, in accordance with the above-mentioned parts by weight is mixed in the boiler, and clean cold water, in order to submerge the powder shall prevail, soaking 60 minutes, then adding cold water, submerged over-powder 2-3cm, decoction, first after heating to boil with the conflagration, to use small fire, to maintain boiling to 60 minutes, after the filtrate crosses , proper amount of water, re-boil out, filtering, merging two filtrate, concentrated under reduced pressure to remove water, to obtain the dry, pulverized to 100 meshes.

The surface-active agent is a fluorine-containing surface active agent, preferably amphoteric fluorine-containing surface active agent, such as perfluoro alkyl betaine conventional amphoteric fluorine-containing surfactant, further preferably represented by the formula shown in the two sexes of the fluorine-containing surface active agent.

.

For wherein n 10-10000, preferably 50-3000.

As shown in this formula the specific preparation of surfactant in the is provided with a thermometer, a reflux condenser in the reactor  , trifluoroethyl methacrylate   of adding fluorine-containing monomer   16.812   g   (0.1   mol)  , chloropropene   7.653   g   (0.1   mol), acrylic acid   7.206   g   (0.1   mol) and an appropriate amount of distilled water is used as solvent  ,   then adding 1.077g (0.008mol) anhydrous sodium sulfite and 0.839g (0.037mol) ammonium persulfate  ,   pH   is adjusted with ammonia water   7.0-7.5,   in the   50-60 [...] reaction under stirring   °C   10   h-12   h;   disposable into trimethylamine   10.747   g   (0.12mol)  ,   slow cooling to the 40 [...] ,   to continue the stirring reaction   4   h,   cessation of the reaction, after purifying repeatedly with absolute ethanol, the solution is removed by reduced pressure distillation in water, ethanol  ,   to obtain the final viscous product amphoteric fluorine-containing surfactant   30.441   g.

The preparation method is merely one illustration, in the actual process of preparation can be prepared according to the above-mentioned molar ratio relationship.

The following detailed description of the embodiments the embodiments of the present invention, the application of the present invention for solving the technical problem the technical means, and the realization of a technical effect can be fully understand and according to the process in order to implement.

Embodiment 1

Chinese medicine extraction component 1

The windproof 25g, Poria (Indian bread) 15g, Japanese knotweed 45g, west carthamine 15g, Gorgon euryale 15g, fructus Ligustri Lucidi 25g, Herba Taraxaci (taraxacum, dandelion) 25g, fructus cnidii 15g, notopterygium 15g, unused 25g, cirrhifolium 25g, COiX seed 25g, Chinese tamarisk 15g, saltiest shrimp flower 10g, semen Cuscutae 20g, ivy 15g, Arctium Fructus Arctii (great burdock achene) 30g, Cimicifugae 25g, arnebia 15g, natural indigo 30g, caulis Piperis kadsurae 15g, cicadella 40g, red balloonflower 15g, rabbit hair wormwood 15g and licorice 15g to pulverize separately, is poured into the pot mix, add clean cold water, in order to submerge the powder shall prevail, soaking 60 minutes, then adding cold water, submerged over-powder 2-3cm, decoction, first after heating to boil with the conflagration, to use small fire, to maintain boiling to 60 minutes, after the filtrate crosses , proper amount of water, re-boil out, filtering, merging two filtrate, concentrated under reduced pressure to remove water, to obtain the dry, pulverized to 100 meshes.

Embodiment 2   Chinese medicine extraction component 2

The windproof 20g, Poria (Indian bread) 10g, Japanese knotweed 40g, west carthamine 10g, Gorgon euryale 10g, fructus Ligustri Lucidi 20g, Herba Taraxaci (taraxacum, dandelion) 20g, fructus cnidii 10g, notopterygium 10g, unused 20g, cirrhifolium 25g, COiX seed 25g, Chinese tamarisk 15g, saltiest shrimp flower 10g, semen Cuscutae 20g, ivy 15g, Arctium Fructus Arctii (great burdock achene) 30g, Cimicifugae 25g, arnebia 15g, natural indigo 30g, caulis Piperis kadsurae 15g, cicadella 40g, red balloonflower 15g, rabbit hair wormwood 15g and licorice 15g to pulverize separately, is poured into the pot mix, add clean cold water, in order to submerge the powder shall prevail, soaking 60 minutes, then adding cold water, submerged over-powder 2-3cm, decoction, first after heating to boil with the conflagration, to use small fire, to maintain boiling to 60 minutes, after the filtrate crosses , proper amount of water, re-boil out, filtering, merging two filtrate, concentrated under reduced pressure to remove water, to obtain the dry, pulverized to 100 meshes.

Embodiment 3   Chinese medicine extraction component 3

The windproof 25g, Poria (Indian bread) 15g, Japanese knotweed 45g, west carthamine 15g, Gorgon euryale 15g, fructus Ligustri Lucidi 25g, Herba Taraxaci (taraxacum, dandelion) 25g, fructus cnidii 15g, notopterygium 15g, unused 25g, cirrhifolium 30g, COiX seed 30g, Chinese tamarisk 20g, saltiest shrimp flower 15g, semen Cuscutae 25g, ivy 20g, Arctium Fructus Arctii (great burdock achene) 35g, Cimicifugae 30g, arnebia 20g, natural indigo 35g, caulis Piperis kadsurae 20g, cicadella 45g, red balloonflower 20g, rabbit hair wormwood 20g and licorice 20g to pulverize separately, is poured into the pot mix, add clean cold water, in order to submerge the powder shall prevail, soaking 60 minutes, then adding cold water, submerged over-powder 2-3cm, decoction, first after heating to boil with the conflagration, to use small fire, to maintain boiling to 60 minutes, after the filtrate crosses , proper amount of water, re-boil out, filtering, merging two filtrate, concentrated under reduced pressure to remove water, to obtain the dry, pulverized to 100 meshes.

Embodiment 4   toxicologists detection

Acute toxicity test

Animal: kunming mouse, weight 21-24g, the male half.

LD50 computing: using a modified invader law , the mouse random divided into 5 groups, each group of 10 only, the male half, the embodiment 1 preparation of Chinese medicine extraction component 1 adding distilled water dissolved, into the maximum concentration, according to the mouse to the maximum allowable capacity, the order of the crude drug dose to 18, 14.4, 11.5, 9.2, 7.4(g/kg)  , in animal fasting (not forbidden water) 18 hours, a day is divided into to two times (interval and a half hours), each 0.5 ml, observe the animal mortality.

The maximum tolerance dosimetrically (MTD value): taking mouse 20 only, the male 10 only. The embodiment 1 preparation of Chinese medicine extraction component 1 adding distilled water dissolved, into the highest concentration, the maximum endures the quantity according to the animals, can be drawn by the feeding device. In animal fasting (not forbidden water) 18 hours, a day is divided into to two times (interval and a half hours), each 0.5 ml (containing crude drug per ml 0.36g), the total quantity is 18g crude drug/kg·d. The continuous observation after 7 days.

Test results

The LD50 when used in calculating the maximum allowable concentration and maximum allowed capacity when given to MICE   (the 18g/Kg  d), not see the death of MICE, the LD50 is not measured, only can try to the maximum tolerance dose, in 7 day observation period, animal its appetite, activities, color, mental state are all normal, the normal development, not see death, shows that acute toxicity is very small, MTD> the 18g/Kg  d.

Cumulative toxicity test

The embodiment 1 preparation of Chinese medicine extraction component 1 adding distilled water to dissolve, according to the to the mouse 7.69, 19 . 18 and 43.21g continuous medication crude drug/kg 15 weeks (1.0 ml/100g weight, every day 2 times) and stop 3 weeks, the result shows that: the Chinese medicine preparation of the invention the hair the RAT, acts, urine, body weight, organ weight, hemograms, the liver and kidney function, blood sugar, blood fat, there is no significant impact on indicators, zoki naked eye is not unusual that change and histological inspection result, drug 15 and stop 3 weeks, RAT all zoki are no obvious change. Note the Chinese medicine preparation of the invention after the RAT small toxicity of long-term use, there is no unusual after drug reaction, application security.

Embodiment 5 surface active agent 1

In the is provided with a thermometer, a reflux condenser in the reactor  , trifluoroethyl methacrylate   of adding fluorine-containing monomer   16.812   g   (0.1   mol)  , chloropropene   7.653   g   (0.1   mol), acrylic acid   7.206   g   (0.1   mol) and an appropriate amount of distilled water is used as solvent  ,   then throws adds anhydrously sodium sulfite and ammonium persulfate  ,   pH   is adjusted with ammonia water   7.0-7.5,   in the   50-60 [...] reaction under stirring   °C   10   h-12   h;   disposable into trimethylamine   10.747   g   (0.12mol)  ,   slow cooling to the 40 [...] ,   to continue the stirring reaction   4   h,   cessation of the reaction, after purifying repeatedly with absolute ethanol, the solution is removed by reduced pressure distillation in water, ethanol  ,   to obtain the final viscous product amphoteric fluorine-containing surfactant   30.441   g.

Surfactant infrared spectrogram see table 1.

Embodiment 6   mask 1

The polyvinyl alcohol 12g is added to the deionized water 100g in, heated to the 70 [...] , dissolving, lowering the temperature to the 50 [...] , then add glycerin 12g, lactic acid 1g stir, further, lowering the temperature to the 30 [...] , adding embodiment 1 preparation of Chinese medicine extraction component 3g and embodiment 5 preparation of surface active ingredient 0.5g, stir, to obtain mask 1.

Embodiment 7   mask 2

The polyvinyl alcohol 12g is added to the deionized water 100g in, heated to the 70 [...] , dissolving, lowering the temperature to the 50 [...] , then add glycerin 12g, lactic acid 1g stir, further, lowering the temperature to the 30 [...] , adding embodiment 1 preparation of Chinese medicine extraction component 3g and surface active ingredient perfluoro alkyl betaine 0.5g, stir, to obtain mask 2.

Embodiment 8 mask 3

The polyvinyl alcohol 12g is added to the deionized water 100g in, heated to the 70 [...] , dissolving, lowering the temperature to the 50 [...] , then add glycerin 12g, lactic acid 1g stir, further, lowering the temperature to the 30 [...] , adding embodiment 5 preparation of surface active ingredient 0.5g, stir, to obtain mask 3.

Embodiment 9   acrimony detection

Use healthy, adult white the family exempts 21 only, weight 2.5-2.7 kg, the male half, divided into 3 groups, each group of 7 only. Two sides of the spinal column of the deburring of the skin 3 cm × 3 cm, the embodiment 6 and embodiment 8 preparation of the mask 1 to the mask 3, are respectively applied to 3 group at one side at the back of the rabbit on the skin material, covered by a layer of cellophane, re-use of the medical tape and the bandage poisonlessness to be fixed, the other side of to compare with distilled water. Each test animal application 4h back, removing is tried , cleaning application part of the warm water for the skin, in 1, 24, the applicator portion 48h observing and recording the skin reaction, "sterilization technical norms" in accordance with the provisions and graded scoring scoring criteria. The skin irritation test shows, the present invention provides the mask to the rabbit's skin stimulation reaction integral is 0, no erythemally, which are not stimulated.

Embodiment 10   spot removing effect

General information

A total of   300 example ephelides patient, the age of   18   years of age, the largest 48   years old, the longest course of 8   years, most short 2 years, are women, random is divided into 3 groups, each group of 100 patients.

Methods of treatment

Treatment 1 group of: the embodiment of the needle-tapping speed percussopunctator with 6 preparation of the mask 1 external application for treating, treatment 2 group with needle-tapping speed percussopunctator embodiment of the 7 preparation of the mask 2 external application for treating, with the embodiment of the needle-tapping speed percussopunctator 8 preparation of the mask 3 external application for treating, fear of pain patients are more than, refused to laser treatment. 1   treatment   30   days, normally continuously taking   3   of treatment, usually pay attention to rest, avoid sunlight irradiation.

Decision criterion curative effect

Recovered: through   3 after   treatment, amber spot obviously disappears; and effectual: through   3 after   treatment, amber spot-obvious lighter, narrow range; effective: through   3 after   treatment, amber spot-lightening shoaled, narrow range; void: through   3 after   treatment, amber spot without any change.

Statistical processing

A grade information will be the form of table data, using a statistical software SPSS13.0 two independent of sample non-parametric test (test order sum) to statistical processing.

Results

Two groups of effect is relatively, results shown in table 1.

Table 1   two groups of the effect is an example.

Compared with the control group, the mask provided by the invention has an obvious effect in removing freckles, p < 0.01, comparability, comparing treatment 1 and group 2 group, the embodiment of the 5 preparing a surfactant more can promote the traditional Chinese medicine extract the effect of removing ephelides aspects.

Of the above, the invention is only the better practical example , this invention is not limited to other forms of, any familiar with the professional technical personnel may utilize the above-mentioned disclosed technical content is equivalent or modified by changing the equivalent embodiment of the change. However all not deviated from the technical scheme of the invention content, according to the invention the technical essence to the above embodiment of any of the simple modification of the, equivalent to change and modification, still belongs to the technical scheme of the invention scope of protection.