07-07-2016 дата публикации
Номер: US20160194305A1
Принадлежит:
Provided are isocitrate dehydrogenase 2 (IDH2) inhibitor compounds useful for treating cancer and methods of treating cancer, comprising administering to a subject in need thereof a compound described herein. Also provided are polymorphic forms of the IDH2 inhibitor compounds characterized by X Ray powder diffraction patterns, having improved physicochemical properties that influence in vivo dissolution rate for formulation purposes. 1. An isolated crystalline form of compound 3 , wherein the isolated crystalline form is Form 16 , characterized by an X-ray powder diffraction pattern having peaks at 2θ angles of 6.8 , 10.6 , 13.6 , 14.2 , and 19.2°±0.2°.2. The isolated crystalline form of claim 1 , characterized by an X-ray powder diffraction pattern substantially similar to .3. An isolated crystalline form of compound 3 claim 1 , wherein the isolated crystalline form is Form 1 claim 1 , characterized by an X-ray powder diffraction pattern having peaks at 2θ angles of 8.9 claim 1 , 13.0 claim 1 , 18.9 claim 1 , 23.8 claim 1 , and 28.1°±0.2°.4. The isolated crystalline form of claim 3 , characterized by an X-ray powder diffraction pattern substantially similar to .5. An isolated crystalline form of compound 3 claim 3 , wherein the isolated crystalline form is Form 2 claim 3 , characterized by an X-ray powder diffraction pattern having peaks at 2θ angles of 12.7 claim 3 , 17.1 claim 3 , 19.2 claim 3 , 23.0 claim 3 , and 24.2°±0.2°.6. The isolated crystalline form of claim 5 , characterized by an X-ray powder diffraction pattern substantially similar to .7. An isolated crystalline form of compound 1 claim 5 , wherein the isolated crystalline form is Form 3 claim 5 , characterized by an X-ray powder diffraction pattern having peaks at 2θ angles of 7.5 claim 5 , 9.3 claim 5 , 14.5 claim 5 , 18.8 claim 5 , 21.3 claim 5 , and 24.8°±0.2°.8. The isolated crystalline form of claim 7 , characterized by an X-ray powder diffraction pattern substantially similar to .9. An isolated ...
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