10-07-2014 дата публикации
Номер: US20140194404A1
Автор:
Altman Michael D.,
Ho Ginny Dai,
Lampe John,
Li Guoqing,
McElroy William T.,
Methot Joey L.,
Paliwal Sunil,
Seganish William Michael,
Tan Zheng,
Tulshian Deen,
ZHOU Hua,
ZHU LIANG
Принадлежит:
This invention relates to amidopyrazole compounds that are inhibitors of Interleukin receptor-associated kinases, in particular IRAK-4, and are useful in the treatment of cellular proliferative diseases, for example, cancer, hyperplasia, restenosis, cardiac hypertrophy, immune disorders and inflammation. 2. The compound of wherein Ris aryl claim 1 , wherein said aryl group is optionally substituted with one or two substituents selected from the group consisting of halo claim 1 , cyano claim 1 , R claim 1 , Ccycloalkyl claim 1 , Caminoalkyl claim 1 , Chydroxyalkyl claim 1 , OR claim 1 , NRR claim 1 , NRCOR claim 1 , NRSOR claim 1 , SONRR claim 1 , and CONRR claim 1 , or a pharmaceutically acceptable salt thereof.3. The compound of wherein Ris aryl claim 2 , wherein said aryl group is optionally substituted with Ror OR claim 2 , or a pharmaceutically acceptable salt thereof.4. The compound of wherein Ris phenyl claim 3 , wherein said phenyl group is optionally substituted with Ror OR claim 3 , or a pharmaceutically acceptable salt thereof.5. The compound of wherein Ris heteroaryl claim 1 , wherein said heteroaryl claim 1 , group is optionally substituted with one or two substituents selected from the group consisting of halo claim 1 , cyano claim 1 , oxo claim 1 , hydroxyl claim 1 , imino claim 1 , hydroxyimino claim 1 , R claim 1 , OR claim 1 , O(Ccycloalkyl) claim 1 , (C═O)OR claim 1 , SOR claim 1 , SOR claim 1 , NRR claim 1 , SONRRand NRSOR claim 1 , or a pharmaceutically acceptable salt thereof.6. The compound of wherein Ris heteroaryl claim 1 , wherein said heteroaryl claim 1 , group is optionally substituted with one or two substituents selected from the group consisting of halo claim 1 , cyano claim 1 , oxo claim 1 , hydroxyl claim 1 , imino claim 1 , hydroxyimino claim 1 , R claim 1 , OR claim 1 , O(Ccycloalkyl) claim 1 , (C═O)OR claim 1 , SOR claim 1 , SOR claim 1 , NRR claim 1 , SONRRand NRSOR claim 1 , or a pharmaceutically acceptable salt thereof.7. The ...
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