Display screen or portion thereof with animated graphical user interface

Performance-Based Optimization of QoS Factors

Described herein are one or more self-organizing network (SON) components configured to determine QoS factors associated with QoS classes for a node of a telecommunication network based at least in part on performance metrics, network configuration, or network fault information. The one or more SON components may receive the performance metrics, network configuration, or network fault information from the node, and the performance metrics, network configuration, or network fault information may be associated with communication of traffic of the QoS classes by the node. Upon determining the QoS factors, the one or more SON components may transmit indications of the QoS factors to the node.

System and method for providing point of interest related notifications

A system and method for providing point of interest related notifications within a vehicle that include receiving sensor data associated with an opening of at least one vehicle window of the vehicle. The system and method also include storing a first geo-location of the vehicle based on the sensor data and determining if a subsequent geo-location of the vehicle is within a predetermined vicinity of at least one point of interest. The system and method further include providing at least one point of interest related notification associated with the at least one point of interest if it is determined that the subsequent geo-location of the vehicle is within the predetermined vicinity of the at least one point of interest.

Performance-based optimization of QoS factors

Described herein are one or more self-organizing network (SON) components configured to determine QoS factors associated with QoS classes for a node of a telecommunication network based at least in part on performance metrics, network configuration, or network fault information. The one or more SON components may receive the performance metrics, network configuration, or network fault information from the node, and the performance metrics, network configuration, or network fault information may be associated with communication of traffic of the QoS classes by the node. Upon determining the QoS factors, the one or more SON components may transmit indications of the QoS factors to the node.

HETEROARYL AMIDE COMPOUNDS, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITIONS THEREOF, AND APPLICATIONS THEREOF

The present invention relates to heteroaryl amide compounds, a preparation method therefor, pharmaceutical compositions thereof and applications thereof, and specifically, relates to a type of compounds having broad-spectrum tumor resistant activity, a preparation method therefor, pharmaceutical compositions containing the compounds, and uses of the compounds in the preparation of drugs for treating tumors. 6. A pharmaceutical composition comprising the compound according to any one of - or a stereoisomer thereof , a prodrug thereof , a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate thereof and optionally a pharmaceutically acceptable excipient.7. Use of the compound according to any one of - or a stereoisomer thereof , a prodrug thereof , a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate thereof or the pharmaceutical composition according to in the manufacture of a medicament for treating tumor growth and metastasis , wherein the tumor includes but not limited to: gastric cancer , liver cancer , blood tumor , osteosarcoma , prostate cancer , breast cancer , lung cancer. The invention relates to the field of medicinal chemistry, and in particular to a type of compounds having broad-spectrum antitumor activity, a method for the preparation thereof, a pharmaceutical composition comprising the same, and use of these compounds in the manufacture of a medicament for treating tumors.Cancer is a malignant disease that seriously threatens human life and health, and its overall incidence is still on the rise in the world. The large-scale sequencing results of tumor genomes in recent years have revealed the high complexity of genetic variations in tumors. The research of tumor therapy faces challenges including most tumor cells having multiple tumor-driven mutation genes, tumor heterogeneity and tumor evolution, and it is difficult for most tumor-driven mutation genes to be as a treatment target and the like ...

Substituted aryl ether compound, preparation method thereof, pharmaceutical composition and use thereof

The present invention relates to a compound having the following formula, or a stereoisomer thereof, a prodrug thereof, a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate thereof, preparation method thereof, pharmaceutical composition comprising the same and use of the compound in the manufacture of a medicament for preventing or treating tumor, wherein the substituents are as defined in the specification.

3D interaction method, device, computer equipment and storage medium

The embodiment of the present application discloses a 3D interaction method, device, computer equipment and storage medium. The method comprises the steps of acquiring motion trail data of a gesture; identifying hand joint position information of the gesture based on the motion trail data; identifying a trigger as a corresponding trigger gesture to realize an interaction operation in an interactive interface based on stay or movement of the hand joint position information within a preset time, wherein the gesture is within an acquisition scope of non-contact gesture control equipment. Thus, the usability of non-contact gesture recognition is improved and the misjudgment rate is reduced with higher operational fluency, better compatibility and improved user experience.

Display screen or portion thereof with animated graphical user interface

System for providing mobile power

The present invention discloses a system for providing mobile power, in which all equipment required for the mobile power are integrated on three transport vehicles, which can be combined for transport as a whole, greatly reducing the connection time required for field operations, with flexible combinations and wider applicability. An exhaust system can be flexibly connected to the side or the top. An air intake system, a gas turbine engine and a generator are connected at the same axial direction, avoiding unnecessary elbows, with small intake pressure losses and a stable flow direction.

Display screen or portion thereof with animated graphical user interface

FUSED BICYCLIC PYRIMIDINE DERIVATIVES AND USES THEREOF

The present invention provides novel compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g., lung cancer, breast cancer, leukemia, lymphoma, melanoma, multiple myeloma, Ewing's sarcoma, osteosarcoma, brain cancer, neuroblastoma), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of a kinase (e.g. a protein kinase (e.g. a cyclin-dependent kinase (CDK) (e.g. CDK7, CDK12, or CDK13) or a lipid kinase such as a phosphatidylinositol-5-phosphate 4-kinase (PIP4K) (e.g., PI5P4Kα, PI5P4Kβ, or PI5P4Kγ)) in the subject. 36-. (canceled)811-. (canceled)12. The compound of claim 1 , wherein Ring A is a substituted or unsubstituted claim 1 , bicyclic heteroaryl ring.1314-. (canceled)1618-. (canceled)2021-. (canceled)2324-. (canceled)25. The compound of claim 1 , wherein Ring A is a substituted or unsubstituted claim 1 , monocyclic heteroaryl ring.2627-. (canceled)2930-. (canceled)31. The compound of claim 1 , wherein Ring A is a substituted or unsubstituted claim 1 , monocyclic heterocyclic ring.3233-. (canceled)3540-. (canceled)41. The compound of claim 1 , wherein Lis a bond.42. (canceled)43. The compound of claim 1 , wherein Lis —O—.44. The compound of claim 1 , wherein Lis —NR—.4547-. (canceled)48. The compound of claim 1 , wherein X is —NR—.4950-. (canceled)51. The compound of claim 1 , wherein Lis —NRC(═O)— or —C(═O)NR—.5259-. (canceled)6167-. (canceled)6970-. (canceled)7274-. (canceled)7677-. (canceled)78. A pharmaceutical composition comprising a compound of claim 1 , or ...

Method, device, system and storage medium for displaying a holographic portrait in real time

The embodiment of the present application discloses a method, device, system and storage medium for displaying a holographic portrait in real time, applicable to reducing latency and achieving real-time display. A method in the application embodiment comprises: acquiring portrait data of a figure through somatosensory equipment; acquiring portrait data within a preset range as effective portrait data; blurring and storing the effective portrait data; sending the blurred effective portrait data to holographic display equipment frame by frame based on a first-in first-out principle, so as to display the effective portrait data of the figure on holographic projection of the holographic display equipment in real time, achieve real-time display of the holographic portrait, have a lower latency and improve user experience.

Fusing device

The present disclosure provides a multifunctional fuse. The multifunctional fuse includes a fuse element, a pre-charging resistor, and an inner housing. The inner housing is provided with a receiving cavity, the fuse element is received in the receiving cavity, and the pre-charging resistor is wound around an outer side of the inner housing and is in contact with the inner housing. The multifunctional fuse of the present disclosure resolves problems of large volumes and high costs of a pre-charging resistor and a fuse in a high voltage circuit in the related art.

Super low pressure drop packing sheet with diversion windows and its structured packing

A low pressure drop structured packing sheet with diversion windows, which are formed on both crests and troughs. When in the expanded state where the diversion window and packing sheet are flat on the same plane, the diversion window has an opening and a fan-shaped portion, with the area of the opening being 0%-1000% of that of the fan-shaped portion. Two side intersection lines between the fan-shaped portion and packing sheet is symmetrical with respect to a central folding line which divides the fan-shaped portion into a left part and a right part. The two side intersection lines intercept to each other with an angel of about 10°-170°. When in the operating state where the diversion window and packing sheet are partially folded towards opposite directions, the fluid at the trough flows to a crest of the other side of the packing sheet with the help of diversion windows, thus increasing the area of vapor-liquid mass transfer. Additionally, when liquid goes across the diversion window, ...

Factor IXa inhibitors

The present invention provides a compound of Formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing unstable angina, refractory angina, myocardial infarction, transient ischemic attacks, atrial fibrillation, thrombotic stroke, embolic stroke, deep vein thrombosis, disseminated intravascular coagulation, ocular build up of fibrin, and reocclusion or restenosis of recanalized vessels. The compounds are selective Factor IXa inhibitors.

Electronic display for a wearable device with graphical user interface

Electronic device

An electronic device includes a main body, a lid body, a hinge, a notch, and a cable. The main body includes a connecting side where the lid body is pivotally mounted to the main body. The hinge is disposed on the connecting side for mounting the lid body to the main body, and includes a fixing frame mounted to one of the main body and the lid body and a pivot member mounted to the other of the main body and the lid body. The notch is defined on one side of the pivot member. The cable extends along the notch and transmits electrical signals between the main body and the lid body.

Phase correction systems and methods of magnetic resonance images

A magnetic resonance (MR) imaging method of correcting phase errors is provided. The method includes applying, by an MR system, a pulse sequence to acquire the precorrection MR image. The method also includes acquiring, by the MR system, reference k-space data having a field of view (FOV) in a phase-encoding direction that is twice or more greater than an FOV of the precorrection MR image in the phase-encoding direction, wherein the reference k-space data and MR signals of the precorrection MR image are acquired with the same type of pulse sequences. The method further includes splitting the reference k-space data into first k-space data and second k-space data, generating a phase error map based on the first k-space data and the second k-space data, generating a phase-corrected image of the precorrection MR image based on the phase error map, and outputting the phase-corrected image.

Electronic display for a wearable device presenting a graphical user interface

Method for the preparation of a protein peptide, a protein peptide and use thereof

The present invention discloses a method for the preparation of a protein peptide, peptide powder prepared thereby, and use of the peptide powder in hypouricemic food products or health care products. The peptide powder is capable of inhibiting the activity of xanthine oxidase and effectively reducing uric acid. The method in an example of the present invention comprises: mincing the tuna, heating with steam or water to obtain a pretreated tuna, enzymolyzing the pretreated tuna, deactivating the enzyme, centrifuging, removing impurities to obtain a supernatant, concentrating, and drying to obtain the peptide powder of interest.

Image processing apparatus, method thereof and program therefor

An image processing apparatus includes a direction detection unit configured to detect a direction of a picture pattern of each picture in an input image having a predetermined color pixel array; a moire detection unit configured to detect a moire level by periodicity of a pixel value of each pixel in the input image depending on the direction as a moire index value; and a moire suppression unit configured to suppress the moire level in the input image based on the moire index value detected by the moire detection unit. A method thereof and a program therefor are also provided.

Performance-based optimization of QoS factors

Described herein are one or more self-organizing network (SON) components configured to determine QoS factors associated with QoS classes for a node of a telecommunication network based at least in part on performance metrics, network configuration, or network fault information. The one or more SON components may receive the performance metrics, network configuration, or network fault information from the node, and the performance metrics, network configuration, or network fault information may be associated with communication of traffic of the QoS classes by the node. Upon determining the QoS factors, the one or more SON components may transmit indications of the QoS factors to the node.

Factor IXa Inhibitors

The present invention provides a compound of Formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing unstable angina, refractory angina, myocardial infarction, transient ischemic attacks, atrial fibrillation, thrombotic stroke, embolic stroke, deep vein thrombosis, disseminated intravascular coagulation, ocular build up of fibrin, and reocclusion or restenosis of recanalized vessels. The compounds are selective Factor IXa inhibitors. 3. The compound of wherein Y is aryl claim 1 , which is optionally substituted with one or two substituents independently selected from the group consisting of halo claim 1 , Rand OR claim 1 , or a pharmaceutically acceptable salt thereof.4. The compound of wherein Z is triazolyl claim 1 , benzimidazolyl claim 1 , pyrimidinyl claim 1 , imidazopyridinyl claim 1 , imidazolyl or pyridinyl claim 1 , wherein said groups are optionally substituted with one or two substituents independently selected from the group consisting of halo claim 1 , oxo claim 1 , R claim 1 , OR claim 1 , (C═O)NRR claim 1 , (C═O)R claim 1 , (C═O)OR claim 1 , (C═O)heterocyclyl-OH and Ccycloalkyl claim 1 , or a pharmaceutically acceptable salt thereof.5. The compound of wherein Z is triazolyl claim 1 , which is optionally substituted with one or two substituents independently selected from the group consisting of halo claim 1 , oxo claim 1 , R claim 1 , ORand Ccycloalkyl claim 1 , or a pharmaceutically acceptable salt thereof.6. The compound of wherein Ris phenyl claim 1 , which is optionally substituted with one or two substituents independently selected from the group consisting of halo claim 1 , R claim 1 , ORand (C═O)OR claim 1 , or a pharmaceutically acceptable salt thereof.7. The compound of wherein Ris H claim 1 , Ris H claim 1 , Ris H claim 1 , Ris H claim 1 , or a pharmaceutically acceptable salt thereof.8. The compound of selected from:N-(1-hydroxy-2,7-dimethyl-1,2,3,4- ...

Factor IXa Inhibitors

The present invention provides a compound of Formula I, and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing unstable angina, refractory angina, myocardial infarction, transient ischemic attacks, atrial fibrillation, thrombotic stroke, embolic stroke, deep vein thrombosis, disseminated intravascular coagulation, ocular build up of fibrin, and reocclusion or restenosis of recanalized vessels. The compounds are selective Factor IXa inhibitors.

GATE DRIVE CONTROLLER CIRCUIT WITH ANTI-SATURATION CIRCUIT AND POWER UP CIRCUIT THEREFOR

A high side isolated gate drive controller circuit is presented with an on-time limiting circuit to prevent isolation transformer saturation as well as a universal power up circuit adaptable to power the driver with constant voltage for different input voltage levels.

DETERMINING DROPPED CALL RATES IN IP MULTIMEDIA NETWORKS

Systems and methods are described herein for determining dropped call rates (DCR) for various communications networks, such as IP Multimedia Networks (IMS), which include Voice over LTE (VoLTE) networks. For example, the systems and methods utilize data (e.g. abnormal cause codes) generated by layers of the IMS networks, such as a Session Initiation Protocol (SIP) layer of the IMS network, when determining dropped call rates for IMS networks. 1. At least one non-transitory computer-readable medium carrying instructions , which when executed by at least one data processor , determine performance of an IP Multimedia System (IMS) network , comprising: 'wherein the at least one session has at least one failure within at least one application layer of a Voice over LTE (VoLTE) network;', 'identifying call detail records, wherein the identified call detail records include individual records that each include at least one Session Initiation Protocol (SIP) layer code associated with at least one session,'}computing a dropped call or failed session rate for the VoLTE network based on identified call detail records with SIP layer codes for sessions having failures; andinitiating an action based on the computed dropped call or failed session rate for the VoLTE network.2. The computer-readable medium of claim 1 , further comprising:accessing a baseline dropped call rate provided by a radio access network (RAN) component of the IMS network; andadjusting the baseline dropped call rate with the computed dropped call or failed session rate for the IMS network to determine a modified call rate for the IMS network that is based on information obtained from a SIP layer of the IMS network and information obtained from a radio access layer of the IMS network.3. The computer-readable medium of claim 1 , wherein computing the computed dropped call or failed session rate includes determining an overall dropped call rate for the IMS network based on a single radio voice call continuity ( ...

SUBSTITUTED PENTA-FUSED HEXA-HETEROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR, DRUG COMBINATION AND USE THEREOF

A type of substituted penta-fused hexa-heterocyclic compounds having selective inhibition for PIKfyve kinase, a pharmaceutically acceptable salt and pharmaceutically acceptable solvate thereof, a method for the preparation thereof, a pharmaceutical composition comprising the same, and use of these compounds in the manufacture of a medicament for preventing or treating a disease associated with PIKfyve in vivo, in particular in the manufacture of a medicament for preventing or treating tumor growth and metastasis. 11. A pharmaceutical composition , comprising the compound according to any one of - or a stereoisomer thereof , a prodrug thereof , a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate thereof and optionally a pharmaceutically acceptable excipient.13. Use of the compound according to any one of - or a stereoisomer thereof , a prodrug thereof , a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate thereof or a pharmaceutical composition according to in the manufacture of a medicament for preventing or treating PIKfyve-mediated diseases in vivo , in particular in the manufacture of a medicament for preventing or treating growth and metastasis of tumor with characteristics of K-RAS mutation or nutrient acquisition disorders or non-Hodgkin's lymphoma.14. Use according to claim 13 , wherein the medicament causes vacuolation of cells claim 13 , optionally claim 13 , the medicament causes vacuolation of cells by inhibiting PIKfyve.15. Use according to claim 13 , wherein the PIKfyve-mediated disease is cancer claim 13 , preferably breast cancer claim 13 , most preferably triple negative breast cancer.16. A method of treating PIKfyve-mediated cancer claim 13 , which comprises administering to a subject an effective amount of the compound according to any one of - or a stereoisomer thereof claim 13 , a prodrug thereof claim 13 , a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable ...

Diamino-alkylamino-linked arylsulfonamide compounds with selective activity in voltage-gated sodium channels

Disclosed are compounds of Formula A, or a salt thereof, where Q, X, R1 and R2 are as defined herein, which compounds have properties for inhibiting Nav1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A or their salts, and methods of treating pain (acute, post-operative, neuropathic), or cough or itch disorders using the same.

RIDE-HAILING VEHICLE IDENTIFICATION

The present disclosure generally relates to methods and systems for determining usage of a vehicle. A vehicle monitoring system may include, a memory, at least one processor coupled to the memory, and a sensory system that generates vehicle trip data during a monitoring window. The vehicle monitoring system may partition the trip data into a base group and a contrast group. The vehicle monitoring system may calculate a similarity score between the contrast group and the base group. The vehicle monitoring system may determine that the vehicle has been used for commercial purposes in response to the similarity score satisfying a threshold.

Display screen or portion thereof with transitional graphical user interface

IDENTIFYING AND RESOLVING TELECOMMUNICATION NETWORK PROBLEMS USING NETWORK EXPERIENCE SCORE

The disclosed system identifies and resolves telecommunication network problems and/or problems with devices utilizing the network. The system segments the user devices into groups having similar characteristics, by grouping together devices more likely to leave the network, and devices less likely to leave the network. Each group of devices has a trained machine learning model, to predict the NEX score for each device. The system focuses on devices with a low NEX score. The system determines whether the problem is with the network and/or the problem is with the device. The system gathers information from network monitoring software and determine which tower caused, for example, the call to drop. The system determines technological capability of the device from the device TAC number. The system suggests solutions to the network problems by suggesting adding a sector, tuning an antenna, etc., or if the device has problems, adjusting phone settings.

System for providing mobile power

The present invention discloses a system for providing mobile power, in which the required equipment for the power supply system at fracturing fields as well as connection cables and connection hoses are integrated properly, assigned onto three transport vehicles for movement and effectively connected. Intake components and a turbine generation system are combined on a first transport vehicle and installed together, then transported to customer sites directly, thus saving the installation time at the user sites. The two different designs on the locations of an exhaust stack and an exhaust silencer not only meet the requirements of road transportation, but also meet the requirements of exhaust gas emission during operations.

PROGRAMMED START CIRCUIT FOR BALLAST

A programmed start ballast circuit is presented having a mode control circuit to selectively switch an inverter output load to control operation for cathode preheating, step dimming and/or anti-arcing operation. 1. A programmed start ballast circuit for powering at least one light source , the ballast circuit comprising:a DC circuit operative to provide a DC output at first and second DC output terminals; a first capacitance and a second capacitance coupled in series between the first and second DC output terminals and joined with one another at a first intermediate node,', 'a first switching device and a second switching device coupled in series between the first and second DC output terminals and joined with one another at a second intermediate node, and', 'a first transformer with a first primary winding coupled between the second intermediate node and a third intermediate node;, 'an inverter circuit operatively coupled to the DC circuit to convert the DC output to produce an AC output to power at least one light source, the inverter comprisinga second transformer with a second primary winding coupled between the first and third intermediate nodes; anda mode control circuit operative in a first mode to selectively couple the third intermediate node with one of the first and second DC output terminals to reduce a voltage potential across the second primary winding, and in a second mode to disconnect the third intermediate node from the second DC output terminal.2. The ballast circuit of claim 1 , where the mode control circuit comprises a fourth capacitance and a switching device coupled in series with one another between the third intermediate node and the second DC output terminal claim 1 , the switching device being conductive in the first mode and non-conductive in the second mode.3. The ballast circuit of claim 2 , where the second transformer comprises at least one secondary winding operative to heat a cathode of the at least one light source when a voltage ...

Terminal backup and recovery method

The invention discloses a terminal backup and recovery method. When in backup, a user interface is provided at a terminal side first, so as to provide, according to a preset display policy, different backup categories for a user to select, wherein the different backup categories comprise different backup objects. Then, according to a backup category and object selected by the user, at the terminal side, a terminal file corresponding to the backup object is backed up at a cloud server according to a preset backup policy. When in recovery, according to a recovery category and object selected by the user, a file already backed up by the terminal/user and corresponding to the backup object is determined at the cloud server, and according to a preset recovery policy, corresponding recovery is executed at the terminal side by using the backed-up file. The invention provides classified backup and recovery, and increases the speed of backup and recovery.

HYDROXYALKYLAMINE- and HYDROXYCYCLOALKYLAMINE-SUBSTITUTED DIAMINE-ARYLSULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS

Disclosed are compounds of Formula A, or a salt thereof: wherein R 1 , R 2 , and E are defined herein, which compounds have properties for inhibiting Na v 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A or their salts, and methods of treating pain disorders, cough, and itch using the same.

Determining dropped call rates in IP multimedia networks

Systems and methods are described herein for determining dropped call rates (DCR) for various communications networks, such as IP Multimedia Networks (IMS), which include Voice over LTE (VoLTE) networks. For example, the systems and methods utilize data (e.g. abnormal cause codes) generated by layers of the IMS networks, such as a Session Initiation Protocol (SIP) layer of the IMS network, when determining dropped call rates for IMS networks.

Home Media Switch

A media switch includes a backplane. A controller module is connected to the backplane for transferring a user command to a media device. A set of audio/video signal busses are connected to the backplane for transferring signals. A power bus is connected to the backplane for supplying power. A bus interface is connected to the bus to provide a connection point for the media device. A bus switch is positioned between the interface and the bus for transferring signals to the bus. The switch is operated by the controller module. A command bus is connected to the backplane for transferring a user command to the media device via a command interface.

Method, Device, System and Storage Medium for Displaying A Holographic Portrait in Real Time

The embodiment of the present application discloses a method, device, system and storage medium for displaying a holographic portrait in real time, applicable to reducing latency and achieving real-time display. A method in the application embodiment comprises: acquiring portrait data of a figure through somatosensory equipment; acquiring portrait data within a preset range as effective portrait data; blurring and storing the effective portrait data; sending the blurred effective portrait data to holographic display equipment frame by frame based on a first-in first-out principle, so as to display the effective portrait data of the figure on holographic projection of the holographic display equipment in real time, achieve real-time display of the holographic portrait, have a lower latency and improve user experience. 1. A method for displaying a holographic portrait in real time , comprising:collecting portrait data of a figure through somatosensory equipment;acquiring portrait data within a preset range as effective portrait data;blurring and storing the effective portrait data; andsending the blurred effective portrait data to holographic display equipment frame by frame based on a first-in first-out principle, so as to display the effective portrait data of the figure on holographic projection of the holographic display equipment in real time.2. The method according to claim 1 , wherein the step of acquiring portrait data within a preset range as effective portrait data comprises:acquiring portrait data of a figure through a color camera sensor and a depth sensor of somatosensory equipment, each pixel point in the portrait data having corresponding coordinates.3. The method according to claim 1 , wherein the step of blurring and storing the effective portrait data comprises:blurring the effective portrait data by mean filter technology.4. The method according to claim 1 , wherein the portrait data comprises depth information and color information; the step of ...

Ballast with end-of-life protection for one or more lamps

Ballasts are presented with improved end-of-life (EOL) detection of lamp DC voltage components and protection circuits to facilitate user maintenance and extend lamp life using selective dimming with preheating when EOL conditions are detected.

Direct calibration of color imaging devices

A system for and method of determining calibration parameters while only capturing a single image is described herein. Furthermore, traditional calibration algorithms are avoided by the direct determination of the calibration parameters. The determination of the calibration parameters is possible by first determining a training data set from images acquired of a variety of objects with a multitude of colors. Then, using the training data set, regression coefficients are generated. A camera to be calibrated then acquires only one set of image information such as a single picture. Then, using the regression coefficients and the acquired information, the calibration parameters are directly estimated for that camera.

Image processing device, image processing method, program, and imaging device

A signal processing unit performs preprocessing, demosaic processing and color reproduction processing on an image signal. A control unit detects an image area having undergone a characteristic change exceeding a predetermined change amount, by using an image signal before the reproduction processing and an image signal after the color reproduction processing. The control unit associates area information indicating the detection result of the image area having undergone a characteristic change exceeding a predetermined change amount with the image signal after the color reproduction processing, and records the area information on a recording medium, or outputs the area information to an external device. Thus, it becomes possible to detect an image area where a control change caused by color reproduction processing is unnatural.

Additive manufacturing apparatus utilizing combined electron beam selective melting and electron beam cutting

An additive manufacturing apparatus utilizing combined electron beam selective melting and electron beam cutting. One electron beam emitting, focusing, and scanning device (6) is capable of emitting electron beams (67, 68) in three modes of heating, selective melting, and electron beam cutting. The electron beam in the heating mode is emitted to scan and preheat a powder bed (7). The electron beam (67) in the selective melting mode is emitted to scan and melt powder (71) in a section outline to form a section layer of a component. The electron beam (68) in the electron beam cutting mode is emitted to perform one or more cutting scans on inner and outer outlines (74, 75) of a section of the component to obtain accurate and smooth inner and outer outlines of the section. The heating, melting deposition, and outline cutting processes are repeated to obtain a required three-dimensional physical component.

IMPACTFUL PARAMETER DETERMINATION FOR BRAND ENHANCEMENT

An electronic device and a method for impactful parameter determination for brand enhancement is provided. The electronic device receives a plurality of responses for a plurality of questions associated with one or more surveys related to one or more services provided by an organization. The electronic device further determines a first set of responses for a first set of questions from the received plurality of responses. The electronic device further calculates an attribution score for each of the first set of parameters based on the determined first set of responses. The electronic device further determines a first parameter from the first set of parameters based on the calculated attribution scores. The determined first parameter, among the first set of parameters, has a maximum impact on a brand associated with the one or more services. The electronic device further controls a first service associated with the determined first parameter. 1. An electronic device , comprising: receives a plurality of responses for a plurality of questions which are associated with one or more surveys related to one or more services provided by an organization;', 'determines a first set of responses for a first set of questions from the received plurality of responses, wherein the first set of questions are associated with a first set of parameters of a set of service categories related to the one or more services;', 'calculates an attribution score for each of the first set of parameters based on the determined first set of responses, wherein the attribution score indicates an impact of the corresponding parameter on a brand associated with the one or more services;', 'determines, based on the calculated attribution scores, a first parameter from the first set of parameters, wherein the determined first parameter, among the first set of parameters, has a maximum impact on the brand; and', 'controls a first service associated with the determined first parameter., 'circuitry which2. ...

PERMANENT PACKER AND EXTENDED GAS LIFT METHOD USING PERMANENT PACKER

The present invention discloses a permanent packer and an extended gas lift method using the permanent packer, the method comprising: S1. imbedding the extended gas lift embedded pipe when setting the permanent packer, wherein the extended gas lift embedded pipe has an upper end being closed and a lower end being open, is provided therein with a one-way valve through which the fluid can pass from top to bottom; S2. lowering a breaking device from the production casing when in the extended gas lift, to break the upper end of the extended gas lift embedded pipe such that the upper and lower ends of the extended gas lift embedded pipe are communicated; and S3. injecting gas into the production casing, lifting the accumulated liquid in the bottom hole to the ground surface, to complete the extended gas lift. The method does not affect the sealing property of the permanent packer, can fully adapt to the demand in the early and middle stages of gas well development, and meanwhile can realize ...

System and Method of Altering the Appearance of Liquid and Solid Physical Objects or Forms

A system and method for altering the visual appearance of moving physical forms is disclosed. The moving physical forms may include solids, liquids, gasses and any combination thereof. The system and method may include video capturing devices for capturing video footage of the moving forms, a controller for altering the captured video footage of the moving forms, and video projecting devices for projecting the altered video footage back onto the moving forms.

HUMAN PAPILLOMAVIRUS TYPE 31 CHIMERIC PROTEIN AND USE THEREOF

The present invention relates to a human papillomavirus type 31 chimeric protein and a use thereof. Specifically, the present invention relates to a human papillomavirus chimeric protein, containing or being composed of an HPV31L1 protein or HPV31L1 protein mutant, and a polypeptide derived from an HPV73L2 protein and inserted into the HPV31L1 protein or HPV31L1 protein mutant, wherein the HPV31L1 protein is as shown in SEQ ID No. 1, and the HPV73L2 protein is as shown in SEQ ID No. 2.

Display screen or portion thereof with animated graphical user interface

Method for the preparation of skipjack tuna extract having uric acid-lowering effect and the use thereof

The present invention discloses a method for the preparation of skipjack tuna extract having hypouricemic effect and the use thereof, which is simple in processing operations, low in production cost, and is free from pollution. The prepared skipjack tuna extract has a potent hypouricemic effect, and has a significant therapeutic effect on hyperuricemia, with no toxic and side effects. The method in an example of the present invention comprises: pretreating skipjack tuna to obtain a skipjack tuna slurry; enzymolysing the skipjack tuna slurry to obtain a crude enzymolysis liquid; removing fishy smell and bitter taste, removing impurities by activated charcoal, and filtering to obtain a refinded enzymolysis liquid; concentrating under vacuum and spray-drying to obtain the skipjack tuna extract. The present invention further discloses use of the skipjack tuna extract in health care products or food products.

Adaptive mobile power generation system

This disclosure generally relates to power generation methods and systems based on gas turbine engines, and particularly to mobile and adaptive power generation systems and methods based on gas turbine engine for supplying mechanical and/or electrical power for fracturing operations at an oil wellsite. Various systems, platforms, components, devices, and methods are provided for flexibly and adaptively configure one of more gas turbines, hydraulic pumps, and electric generators to support both fracturing and electric demands at a well site. The disclosed implementations enable and facilitate a mobile, adaptive, and reconfigurable power system to provide both mechanical and electric power for hydraulic fracturing operation.

Papillomavirus chimeric protein and application thereof

Provided is a papillomavirus chimeric protein, the skeleton thereof being a papillomavirus L1 protein or a mutant thereof, at least one human papillomavirus 33-type L2 protein or mutant polypeptide thereof being embedded on the skeleton. The present papillomavirus chimeric protein can be used for preparing a vaccine for preventing papillomavirus infections and infection induced disease.

METHODS AND SYSTEMS FOR WHOLE BODY IMAGING

Various methods and systems are provided for scanning an image subject along a scan axis. The method includes stitching sectional datasets acquired from different anatomical sections of the image subject based on locations of a landmark in the sectional datasets. 1. A method for medical imaging , comprising:performing a first sectional scan on a first anatomical section of an image subject to obtain a first sectional dataset;performing a second sectional scan on a second anatomical section of the image subject to obtain a second sectional dataset;determining, with a trained deep learning network, a first location of a landmark in the first sectional dataset and a second location of the landmark in the second sectional dataset; andstitching the first sectional dataset and the second sectional dataset based on the first location of the landmark and the second location of the landmark.2. The method of claim 1 , wherein the first sectional dataset and the second sectional dataset are three-dimensional datasets partially overlapped along a scan axis of the image subject claim 1 , the first location of the landmark is coordinates of the landmark within a first plane perpendicular to the scan axis claim 1 , and the second location of the landmark is coordinates of the landmark within a second plane perpendicular to the scan axis.3. The method of claim 1 , further comprising determining the trained deep learning network by training a deep learning network with a plurality of images and manually labeled landmark locations in the plurality of images before performing the first sectional scan.4. The method of claim 1 , wherein the trained deep learning network includes a bottom-up pathway and a top-down pathway.5. The method of claim 1 , wherein the first sectional dataset and the second sectional dataset are acquired via magnetic resonance imaging claim 1 , and the method further comprising stitching the first sectional dataset and the second sectional dataset based on an ...

Electrode cap grinding and changing all-in-one (AIO) machine

An electrode cap grinding and changing machine is provided. The machine includes a frame, a drive motor having an output end and a balanced floating unit, wherein the balanced floating unit is arranged on the frame, and the drive motor is arranged on the balanced floating unit, the output end of the drive motor penetrates through the balanced floating unit and then is connected with a working table having two sides, the two sides of the working table having a cap dismounting unit and a cap grinding unit drivably interconnected with the output end of the drive motor, and electrode cap storage units arranged at an outermost end of the two sides of the working table or on the frame.

Five-membered-fused-six-membered aza-aromatic ring compound, preparation method thereof, pharmaceutical composition and application thereof

The invention relates to the field of medicinal chemistry, and to five-membered-fused-six-membered aza-aromatic ring compound, preparation method thereof, pharmaceutical composition and application thereof. In particular, the invention relates to a type of compounds capable of specifically enhancing ubiquitination degradation of Ras proteins, a method for the preparation thereof, a pharmaceutical composition comprising the same, and use of these compounds in the manufacture of a medicament for preventing or treating a disease associated with Ras activity in vivo, in particular in the manufacture of a medicament for preventing or treating tumor growth and metastasis.

Ride-hailing vehicle identification

The present disclosure generally relates to methods and systems for determining usage of a vehicle. A vehicle monitoring system may include, a memory, at least one processor coupled to the memory, and a sensory system that generates vehicle trip data during a monitoring window. The vehicle monitoring system may partition the trip data into a base group and a contrast group. The vehicle monitoring system may calculate a similarity score between the contrast group and the base group. The vehicle monitoring system may determine that the vehicle has been used for commercial purposes in response to the similarity score satisfying a threshold.

Display screen or portion thereof with animated graphical user interface

Method of semi-solid indirect squeeze casting for magnesium-based composite material

The present invention relates to a method of semi-solid indirect squeeze casting for Mg-based composite material, which aims at improving the mechanical property of the cast by adding magnesium zinc yttrium quasicrystal of high hardness, high elastic modulus and excellent matrix binding property acting as the reinforcement into the magnesium alloy matrix and manufacturing the cast through smelting using a vacuum atmosphere smelting furnace, agitating with ultrasonic wave assisted vibration in the rotating impeller jet agitation furnace and indirect squeeze casting against the problem of poor wettability, easy agglomeration, inhomogeneous distribution between the reinforcement particles and the matrix materials and poor properties of the manufactured cast. The manufacturing method of the present invention has advanced technologies and detailed and accurate data. The cast has excellent microstructure compactness, no shrinkage cavities and shrinkage defects and the primary phase in the metallographic ...

Factor IXa inhibitors

The present invention provides a compound of Formula I, and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing unstable angina, refractory angina, myocardial infarction, transient ischemic attacks, atrial fibrillation, thrombotic stroke, embolic stroke, deep vein thrombosis, disseminated intravascular coagulation, ocular build up of fibrin, and reocclusion or restenosis of recanalized vessels. The compounds are selective Factor IXa inhibitors.

Sequential regression for calibration from residues

A system for and method of calibrating an imaging device efficiently is described herein. The imaging device acquires an image of an object that is more than one color. The information acquired is then transferred to a computing device. The information is then used to generate a set of data which represents information which was not acquired in the image. The set of data is generated based on statistical prediction using a training data set. Using acquired image information and the set of data, an imaging device is able to be calibrated. Since the process of calibration utilizing this method only requires one image to be acquired and a reduced set of image information to be sent to the computing device, the process is more efficient than previous implementations.

C-TERMINUS MODIFIED HUMAN PAPILLOMAVIRUS TYPE 6 L1 PROTEIN AND USE THEREOF

The present application relates to a C-terminus modified human papillomavirus type 6 L1 protein and use thereof. Specifically, the present application relates to a C-terminus modified human papillomavirus (HPV) type 6 L1 protein, an encoded nucleotide thereof, a vector comprising the nucleotide, a cell comprising the vector, a pentamer or virus-like particle composed of the HPV6 L1 protein, a vaccine containing the pentamer or virus-like particle and a vaccine adjuvant, and the use thereof in prevention of HPV infection and HPV infection-related diseases.

3D Interaction Method, Device, Computer Equipment and Storage Medium

The embodiment of the present application discloses a 3D interaction method, device, computer equipment and storage medium. The method comprises the steps of acquiring motion trail data of a gesture; identifying hand joint position information of the gesture based on the motion trail data; identifying a trigger as a corresponding trigger gesture to realize an interaction operation in an interactive interface based on stay or movement of the hand joint position information within a preset time, wherein the gesture is within an acquisition scope of non-contact gesture control equipment. Thus, the usability of non-contact gesture recognition is improved and the misjudgment rate is reduced with higher operational fluency, better compatibility and improved user experience. 1. A 3D interaction method , comprising ,acquiring motion trail data of a gesture by non-contact gesture control equipment;identifying hand joint position information of the gesture based on the motion trail data; andidentifying a trigger as a corresponding trigger gesture to realize an interaction operation in an interactive interface based on stay or movement of the hand joint position information within a preset time, wherein the gesture is within an acquisition scope of the non-contact gesture control equipment.2. The method according to claim 1 , wherein the step of identifying the hand joint position information of the gesture based on the motion trail data comprises:identifying the hand joint position information of the gesture based on the motion trail data, the hand joint position information includes fingertip coordinates of five fingers and a wrist coordinate.3. The method according to claim 1 , wherein the step of identifying the trigger as the corresponding trigger gesture to realize the interaction operation based on stay or movement of the hand joint position information within the preset time comprises:identifying as a single-finger stay trigger when an accumulated displacement ...

Use of gTso thal in manufacturing medicament for promotion of MS-275 to cross blood-brain barrier

The present invention relates to use of gTso thal in manufacturing a medicament for the promotion of MS-275 to cross the blood-brain barrier (BBB), and belongs to the technical field of pharmaceutical preparation. Administration of the medicament manufactured by the use of the present invention in combination with MS-275 significantly increases MS-275 to cross the BBB into the brain tissue, and prominently promotes the accumulation of MS-275 therein.

Sequential regression for calibration from residues

A system for and method of calibrating an imaging device efficiently is described herein. The imaging device acquires an image of an object that is more than one color. The information acquired is then transferred to a computing device. The information is then used to generate a set of data which represents information which was not acquired in the image. The set of data is generated based on statistical prediction using a training data set. Using acquired image information and the set of data, an imaging device is able to be calibrated. Since the process of calibration utilizing this method only requires one image to be acquired and a reduced set of image information to be sent to the computing device, the process is more efficient than previous implementations.

VIRUS-LIKE PARTICLES OF CAPSID PROTEINS FROM HUMAN PAPILLOMAVIRUS TYPE 16/58/18/6/11 AND THE METHOD FOR PREPARATION AND THE USES THEREOF

Five optimized genes of capsid L1 protein from human papillomavirus type 16, 58, 18, 6 and 11, which are modified by using insect's preferred codons and so on. Method for modifying those genes to express more highly in insect cells. Virus-like particle's vaccine compositions comprising HPV L1 proteins or their functional relatives produced by using those modified genes. Those optimized genes of L1 can be used to produce HPV 16 VLP, HPV 58VLP, HPV 18VLP, HPV 6 VLP, HPV 11VLP in insect cells. Yields of virus-like particles derived from those optimized HPV L1 genes are high. Mixed multivalent vaccines comprising above optimized HPV L1 genes can be used to prevent and treat multiple HPV infection and diseases related with it. 1. An optimally modified HPV 16 L1M gene sequence having a nucleotide sequence shown as SEQ ID NO: 1.2. An optimally modified HPV 58 L1M gene sequence having a nucleotide sequence shown as SEQ ID NO: 2.3. An optimally modified HPV 18 L1M gene sequence having a nucleotide sequence shown as SEQ ID NO: 3.4. An optimally modified HPV 6 L1M gene sequence having a nucleotide sequence shown as SEQ ID NO: 4.5. An optimally modified HPV 11 L1M gene sequence having a nucleotide sequence shown as SEQ ID NO: 5.6. A recombinant pFastBacI plasmid containing an optimally modified gene sequences selected from the group consisting of a nucleotide sequence shown as SEQ ID NO:1 , SEQ ID NO:2 , SEQ ID NO:3 , SEQ ID NO:4 , SEQ ID NO:5.7. A recombinant Bacmid containing an optimally modified gene sequences selected from the group consisting of a nucleotide sequence shown as SEQ ID NO:1 , SEQ ID NO:2 , SEQ ID NO:3 , SEQ ID NO:4 , SEQ ID NO:5.8E. coli. A recombinant DH 10Bac strain containing the recombinant Bacmid according to .9. A recombinant baculoviruses containing an optimally modified gene sequences selected from the group consisting of a nucleotide sequence shown as SEQ ID NO:1 claim 7 , SEQ ID NO:2 claim 7 , SEQ ID NO:3 claim 7 , SEQ ID NO:4 claim 7 , SEQ ID NO:5 ...

SYSTEM FOR PROVIDING MOBILE POWER

The present invention discloses a system for providing mobile power, in which the required equipment for the power supply system at fracturing fields as well as connection cables and connection hoses are integrated properly, assigned onto three transport vehicles for movement and effectively connected. An intake component and a turbine generation system are combined on a first transport vehicle and installed together, then transported to customer sites directly, thus saving the installation time at the user sites. The two different designs on the locations of an exhaust stack and an exhaust silencer not only meet the requirements of road transportation, but also meet the requirements of exhaust gas emission during operations.

METHOD OF MOBILE POWER GENERATION SYSTEM

The present invention discloses a method of a mobile power generation system. A power generation apparatus is respectively quickly connected, through expansion joints, to an intake assembly and an exhaust duct which are separately transported, to implement the quick installation and connection of the power generation system at the fracturing operation site. Two conveyances are respectively provided for the intake assembly and the exhaust duct to achieve more flexible adjustment during connection. While the position of the power generation apparatus is fixed, the intake assembly is moved to connect to an intake chamber of the power generation apparatus, and the exhaust duct is moved to connect to an exhaust collector of the power generation apparatus.

MACHINE LEARNING MODEL BASED RECOMMENDATIONS FOR VEHICLE REMOTE APPLICATION

A server for machine learning model based recommendations for vehicle remote application is provided. The server includes circuitry configured to retrieve customer subscription data associated with a first set of customers related to a set of vehicles. The set of vehicles are controlled with one or more remote applications associated with the server. The circuitry extracts the first set of features from the customer subscription data and trains a machine learning model based on the first set of features and a first feature of the first set of features. The first feature corresponds to a paid subscription of a remote application. The circuitry determines an importance score for each of the first set of features based on the trained machine learning model. The circuitry generates recommendation information related to the remote application, based on the determined importance score and transmits the recommendation information to electronic devices associated with the server.

FASTENING STRUCTURE AND ASSEMBLING METHOD THEREOF

A fastening structure for fastening a hardware component is disclosed. The fastening structure includes a supporting portion defining a through stepped hole including a small-diameter hole and a large-diameter hole. Furthermore, the fastening structure includes a nut wedged into the large-diameter hole. A screw may successively passing through the hardware component and the small-diameter hole to screwably engage with the nut.

SYSTEM FOR PROVIDING MOBILE POWER

The present invention discloses a system for providing mobile power, in which all equipment required for the mobile power are integrated on three transport vehicles, which can be combined for transport as a whole, greatly reducing the connection time required for field operations, with flexible combinations and wider applicability. An exhaust system can be flexibly connected to the side or the top. An air intake system, a gas turbine engine and a generator are connected at the same axial direction, avoiding unnecessary elbows, with small intake pressure losses and a stable flow direction. 1. A system for providing mobile power , comprising a gas turbine generation transport vehicle , an intake ventilation transport vehicle and an exhaust transport vehicle , the intake ventilation transport vehicle is connected in the travel direction of the gas turbine generation transport vehicle , and the exhaust transport vehicle is disposed at one side of the gas turbine generation transport vehicle; whereinthe exhaust transport vehicle comprises an exhaust system, the exhaust system is connected to the side or the top of the gas turbine generation transport vehicle; andthe system for providing mobile power further comprising a lifting mechanism, wherein when the exhaust system is connected to the side of the gas turbine generation transport vehicle, and a side docking of the exhaust system is achieved by the lifting mechanism disposed on the exhaust transport vehicle.2. (canceled)3. (canceled)4. A system for providing mobile power , comprising a gas turbine generation transport vehicle , an intake ventilation transport vehicle and an exhaust transport vehicle , the intake ventilation transport vehicle is connected in the travel direction of the gas turbine generation transport vehicle , and the exhaust transport vehicle is disposed at one side of the gas turbine generation transport vehicle , andthe exhaust transport vehicle comprises an exhaust system, the exhaust system is ...

RADIATING ELEMENT AND BASE STATION ANTENNA

The present disclosure relates to a radiating element, which includes: a dipole arm configured to emit first electromagnetic radiation within a pre-determined first operating frequency band; and a parasitic radiator, configured such that a first induced current induced on the parasitic radiator within a second operating frequency band at least partially cancels a second induced current induced on the dipole arm within the second operating frequency band. In addition, the present disclosure relates to a base station antenna, including: a first radiating element array, configured to emit first electromagnetic radiation within a pre-determined first operating frequency band, and at least a part of first radiating elements in the first radiating element array is constructed as radiating elements according to the present disclosure; a second radiating element array, configured to emit second electromagnetic radiation within a pre-determined second operating frequency band.

Factor IXa inhibitors

The present invention provides a compound of Formula (I) wherein R1is H or C1-6alkyl, R2, is H or C1-6alkyl or CH2OH, R3is H or C1-6alkyl, and R4is H or C1-6alkyl, provided that when R1, R2, and R3are H, R4is C1-6alkyl, and when R1, R2, and R4are H, then R3is C1-6alkyl, and when R1, R3, and R4are H, R2is C1-6alkyl or —CH2OH, and when R2, R3, and R4are H, then R1is C1-6alkyl; A is 1) a 9-10 membered bicyclic heterocycle having 1-3 heteroatoms independently selected from N, S and O, which 9-10 membered bicyclic heterocycle is unsubstituted or substituted with R5and unsubstituted or substituted with R6and unsubstituted or substituted with NH2, or 2) a 6-9 membered monocyclic or bicyclic carbocyclic ring system unsubstituted or substituted with R5, unsubstituted or substituted with R6, and unsubstituted or substituted with —CH2NH2; and B is 1) a 5- or 6-membered monocyclic heterocycle having 1 or 2 heteroatoms independently selected from N, S or O, which is unsubstituted or substituted on a ...

Method and Apparatus for Placing Icon

A method and an apparatus are disclosed for placing icons, which relate to the field of handheld terminal devices and solve the problem where when there are many icons on a main menu or desktop, after the icons on the main menu or desktop are sorted according to initial letters, it is still difficult for a user to find a required program icon from the many icons. The technical solutions of the present invention include: obtaining a characteristic value of an application downloaded from a third party; and according to a preset mapping relationship between a characteristic value and a terminal icon category, placing icons of the application according to a terminal icon category corresponding to the characteristic value of the application. 1. A method for placing icons comprising:obtaining a characteristic value of an application downloaded from a third party; andplacing, according to a preset mapping relationship between the characteristic value and a terminal icon category, an icon of the application according to the terminal icon category corresponding to the characteristic value of the application.2. The method according to claim 1 , wherein the characteristic value comprises an original icon category of the application on the third party claim 1 , and wherein placing claim 1 , according to the preset mapping relationship between the characteristic value and the terminal icon category claim 1 , the icon of the application according to the terminal icon category corresponding to the characteristic value of the application comprises placing claim 1 , according to the preset mapping relationship between the original icon category and the terminal icon category claim 1 , the icon of the application according to the terminal icon category corresponding to the original icon category of the application.3. The method according to claim 2 , wherein obtaining the characteristic value of the application downloaded from the third party comprises:recognizing a text at a link ...

SYSTEM AND METHOD FOR DETERMINING VEHICLE FUELING BEHAVIOR

A system and method for determining vehicle fueling behavior that include receiving sensor data associated with an occurrence of a fueling event associated with fueling of a vehicle and determining a current geo-location of the vehicle based on determining that the fueling event is occurring. The system and method also include determining a fueling station that is being utilized during the fueling event based on the current geo-location of the vehicle. The system and method further include computing at least one fueling behavior pattern based on analyzing data associated with the fueling station and the fueling event.

Travel assisting method and terminal

An embodiment of the present invention discloses a travel assisting method, including: extracting trip information from content saved in a terminal and saving the extracted trip information in a trip list; selecting the trip information from the trip list, automatically connecting to a preset network address or a preset server address, and searching by using part or all of content of each piece of the selected trip information as a key word, so as to obtain assisting information corresponding to the trip information; and generating prompting information. Correspondingly, an embodiment of the present invention further discloses a terminal. The present invention enables the terminal to automatically provide effective reference information for a user according to a trip of the user, solving the problem that an operation is troublesome and time-consuming when the user obtains trip-related assisting information by using the terminal.

NEGATIVE ELECTRODE MATERIAL, NEGATIVE ELECTRODE PLATE, ELECTROCHEMICAL APPARATUS, AND ELECTRONIC APPARATUS

A negative electrode material includes a composite of a silicon-based material (1), a polymer (2), and carbon nanotubes (3), where the polymer (2) contains a first group and a second group, the first group is chemically bonded to the carbon nanotubes (3), and the second group is chemically bonded to the silicon-based material (1). Both the carbon nanotubes (3) and the polymer (2) containing two groups are applied to surfaces of particles of the silicon-based material (1). The two groups of the polymer (2) are chemically bonded to the silicon-based material (1) and the carbon nanotubes (3) respectively, so that bonding force between the silicon-based material (1) and the carbon nanotubes (3) is enhanced and a uniform carbon nanotube (3) coating layer is formed. This can significantly improve conductive performance of the silicon-based material (1), thereby improving cycling performance and rate performance of an electrochemical apparatus.

method for the production of furfural from lignocellulosic biomass material

System for providing mobile power

The present invention discloses a system for providing mobile power, in which the required equipment for the power supply system at fracturing fields as well as connection cables and connection hoses are integrated properly, assigned onto three transport vehicles for movement and effectively connected. Intake components and a turbine generation system are combined on a first transport vehicle and installed together, then transported to customer sites directly, thus saving the installation time at the user sites. The two different designs on the locations of an exhaust stack and an exhaust silencer not only meet the requirements of road transportation, but also meet the requirements of exhaust gas emission during operations.

Systems and methods for communicating recognition-model uncertainty to users

The disclosed computer-implemented method may include (1) receiving information associated with a real-time output of a recognition model adapted to recognize at least one behavior of a user, (2) determining, based on the information, a level of uncertainty associated with the real-time output, (3) modulating at least one attribute of feedback based on the level of uncertainty, and (4) presenting the feedback to the user substantially contemporaneous with the real-time output of the recognition model. Various other methods, systems, and computer-readable media are also disclosed.

METHOD OF FABRICATING DUAL TRENCH ISOLATED EPITAXIAL DIODE ARRAY

The present invention discloses a method of fabricating dual trench isolated epitaxial diode array. This method starts with the formation of heavily-doped first conductivity type regions and heavily-doped second conductivity type regions on the substrate, followed by epitaxial growth, then the formation of the isolations between diode array word lines by deep trench etch and the formation of the isolations between bit lines vertical to deep trenches by shallow trench etch, and finally the formation of separate diode array cells in the regions enclosed by deep and shallow trench isolations by ion implantation. This invention also provides a method of preventing the crosstalk current between adjacent word lines and bit lines of epitaxial diode arrays isolated by foregoing dual shallow trenches. This invention can be used for diode-driven, high-density, large-capacity memory, such as phase change random access memory, resistive memory, magnetic memory and ferroelectric memory; the method thereof is completely compatible with conventional complementary metal-oxide semiconductor (CMOS) process, and because the diode arrays can be formed before the formation of peripheral circuits, no drift of peripheral circuits will be caused by the thermal process thereof, thereby solving the technical challenge of fabricating high-density, large-capacity embedded phase change random access memory. 1. A method of fabricating dual trench isolated epitaxial diode array , characterized by comprising the following steps:(A) form heavily-doped first conductivity type regions on the substrate of the first conductivity type, and then form heavily-doped second conductivity type regions on said heavily-doped first conductivity type regions;(B) form an epitaxial layer on heavily-doped second conductivity type regions;(C) form first trenches deep to heavily-doped first conductivity type regions by lithography and etch so as to divide heavily-doped second conductivity type regions into multiple ...

HIP EXOSKELETON

An exoskeleton wearable on a body of a human having two legs, the exoskeleton comprising a first HAA joint and a second HAA joint to assist the human with leg abduction and adduction movements that are parallel to a frontal plane, each of the first and the second HAA joints having an actuator, each actuator including a motor and a clutch. The exoskeleton further comprises a sensor system for measuring a combined center of mass of the human and the exoskeleton in the frontal plane and a step width of the human in the frontal plane. The exoskeleton further comprises a controller that outputs adjustment angles for each of the first and the second HAA joints based on the center of mass and the step width. The first and the second HAA joints are respectively rotated based on the respective output adjustment angles.

Permanent packer and extended gas lift method using permanent packer

The present invention discloses a permanent packer and an extended gas lift method using the permanent packer, the method comprising: S1. imbedding the extended gas lift embedded pipe when setting the permanent packer, wherein the extended gas lift embedded pipe has an upper end being closed and a lower end being open, is provided therein with a one-way valve through which the fluid can pass from top to bottom; S2. lowering a breaking device from the production casing when in the extended gas lift, to break the upper end of the extended gas lift embedded pipe such that the upper and lower ends of the extended gas lift embedded pipe are communicated; and S3. injecting gas into the production casing, lifting the accumulated liquid in the bottom hole to the ground surface, to complete the extended gas lift. The method does not affect the sealing property of the permanent packer, can fully adapt to the demand in the early and middle stages of gas well development, and meanwhile can realize ...

Intake-exhaust transport apparatus mobile power generation system and assembling method thereof

An intake-exhaust transport apparatus, a mobile power generation system and an assembling method thereof are provided. The assembling method includes: roughly adjusting a position of the intake-exhaust system in a second direction with respect to the power generation apparatus by the second conveyance; jacking up the intake assembly and the exhaust duct as a whole, to be higher than a height of the power generation apparatus by the lifting mechanism; moving the power generation apparatus to a region under the intake-exhaust system by the first conveyance and adjusting a position of the power generation apparatus in the first direction with respect to the intake-exhaust system; and connecting the intake assembly and the exhaust duct to a top of the power generation apparatus.

Mobile power system

The present invention discloses a mobile power system, the whole mobile power system is assigned onto two transport vehicles, achieving effective integration to reduce transport vehicle and transport cost; the two transport vehicles are connected at the side to enable quick and convenient connection in working state, greatly saving installation time; a gas turbine starter is disposed on an exhaust auxiliary transportation unit so that the mobile power system can be started by a gas turbine in totally power failure conditions.

FLEXIBLE CONDUCTIVE DIAPHRAGM, FLEXIBLE VIBRATION SENSOR AND PREPARATION METHOD AND APPLICATION THEREOF

The invention discloses a flexible conductive diaphragm comprising at least one conductive film, and the conductive film comprises a flexible support layer (), a flexible sensitive layer () overlapped on the flexible support layer (), a flexible conductive layer () overlapped on the flexible sensitive layer (), and an electrode () electrically connected with the flexible conductive layer (). The invention further discloses a method for preparing the flexible conductive diaphragm, and a flexible vibration sensor based on the flexible conductive diaphragm. With the combination of the techniques such as the flexible material, the nano-material and the arrayed micro-structure, the flexible vibration sensor of the present invention has the characteristics of high sensitivity, low preparation cost, light weight, small thickness, small size, and being foldable and flexible, and can be applied in wearable or adherable electronic devices. 1. A flexible conductive diaphragm , characterized in that: it comprises at least a conductive film , wherein the conductive film comprises a flexible support layer , a flexible sensitive layer overlapped on the flexible support layer , a flexible conductive layer overlapped on the flexible sensitive layer , and an electrode electrically connected with the flexible conductive layer.2. The flexible conductive diaphragm according to claim 1 , characterized in that: it comprises more than two conductive films which are overlapped claim 1 , wherein the flexible conductive layers of adjacent conductive films are contacted with each other to form a contact resistance layer with a resistance being adjustable.3. The flexible conductive diaphragm according to claim 2 , characterized in that: it comprises a plurality of conductive films which are overlapped claim 2 , and more than two contact resistance layers are formed between the plurality of conductive films.4. The flexible conductive diaphragm according to claim 1 , characterized in that: the ...

C-TERMINALLY MODIFIED HUMAN PAPILLOMAVIRUS TYPE 11 L1 PROTEIN AND USE THEREOF

The present application relates to a C-terminus modified human papillomavirus type 11 L1 protein and the use thereof. Specifically, the present application relates to a C-terminus modified human papillomavirus (HPV) type 11 L1 protein, a nucleotide encoded thereby, a vector containing the nucleotide, a cell containing the vector, a pentamer or virus-like particle composed of the HPV11 L1 protein, and a vaccine containing the pentamer or virus-like particle and a vaccine adjuvant, and the use thereof in the prevention of HPV infection and HPV infection-related diseases.

Pyrimidopyrrole compounds, method for preparing the same, pharmaceutical compositions comprising the same and uses thereof

The present invention relates to a compound of formula I, a stereoisomer, a prodrug, a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate thereof, and a process for preparing the same, a pharmaceutical composition comprising the same, and use of the compound in the preparation of medicine preventing and treating tumors, wherein the substituents are as defined in the specification.

FORGERY DETECTION OF FACE IMAGE

In implementations of the subject matter as described herein, there is provided a method for forgery detection of a face image. Subsequent to inputting a face image, it is detected whether a blending boundary due to the blend of different images exists in the face image, and then a corresponding grayscale image is generated based on a result of the detection, where the generated grayscale image can reveal whether the input face image is formed by blending different images. If a visible boundary corresponding to the blending boundary exists in the generated grayscale image, it indicates that the face image is a forged image; on the contrary, if the visible boundary does not exist in the generated grayscale image, it indicates that the face image is a real image.

Electronic skin, preparation method and use thereof

The invention provides a piezoresistive electronic skin, a preparation method and a use thereof. The piezoresistive electronic skin uses carbon nanotube film as the conductive layer and uses materials provided with micro-nano patterns, such as polydimethylsiloxane, polyethylene terephthalate, polyvinyl alcohol, polyvinyl formal, polyethylene, and so on, as the substrate, enabling the substrate has advantages of high flexibility and being pliable, and it needs low operating voltage and little power consumption, but has high sensitivity and short response time. More importantly, the invention uses the patterned flexible substrate as the basis, greatly improving the sensitivity of electronic skin reacting to tiny applied force from outside. The invention also provides a capacitive electronic skin and a preparation method thereof. Further, the invention also provides a use of the piezoresistive electronic skin or the capacitive electronic skin on speech recognition, pulse detection, medical ...

SYSTEMS AND METHODS FOR SIGNALING COGNITIVE-STATE TRANSITIONS

The disclosed computer-implemented method may include (1) acquiring, via one or more biosensors, one or more biosignals generated by a user of a computing system, (2) using the one or more biosignals to anticipate a transition to or from a cognitive state of the user, and (3) providing a signal indicating the transition to or from the cognitive state of the user to an intelligent-facilitation subsystem adapted to perform one or more assistive actions to reduce the user's cognitive load. Various other methods, systems, and computer-readable media are also disclosed. 1. A computer-implemented method comprising:acquiring, via one or more biosensors, one or more biosignals generated by a user of a computing system, the computing system comprising an intelligent-facilitation subsystem adapted to perform one or more assistive actions to reduce the user's cognitive load;using the one or more biosignals to anticipate a transition to or from a cognitive state of the user; andproviding, to the intelligent-facilitation subsystem, a signal indicating the transition to or from the cognitive state of the user.2. The computer-implemented method of claim 1 , wherein the acquiring claim 1 , the using claim 1 , and the providing are performed when the user is not attentively engaged with the computing system.3. The computer-implemented method of claim 1 , wherein:the one or more biosensors comprise one or more eye-tracking sensors;the one or more biosignals comprise signals indicative of gaze dynamics of the user; andthe signals indicative of gaze dynamics of the user are used to anticipate the transition to or from the cognitive state of the user.4. The computer-implemented method of claim 3 , wherein the signals indicative of gaze dynamics of the user comprise a measure of gaze velocity.5. The computer-implemented method of claim 3 , wherein the signals indicative of gaze dynamics of the user comprise at least one of:a measure of ambient attention; ora measure of focal attention.6. ...

ELECTRONIC SKIN, PREPARATION METHOD AND USE THEREOF

The invention provides a piezoresistive electronic skin, a preparation method and a use thereof. The piezoresistive electronic skin uses carbon nanotube film as the conductive layer and uses materials provided with micro-nano patterns, such as polydimethylsiloxane, polyethylene terephthalate, polyvinyl alcohol, polyvinyl formal, polyethylene, and so on, as the substrate, enabling the substrate has advantages of high flexibility and being pliable, and it needs low operating voltage and little power consumption, but has high sensitivity and short response time. More importantly, the invention uses the patterned flexible substrate as the basis, greatly improving the sensitivity of electronic skin reacting to tiny applied force from outside. The invention also provides a capacitive electronic skin and a preparation method thereof. Further, the invention also provides a use of the piezoresistive electronic skin or the capacitive electronic skin on speech recognition, pulse detection, medical robot, etc.

System and Method of Altering the Appearance of Liquid and Solid Physical Objects or Forms

A system and method for altering the visual appearance of moving physical forms is disclosed. The moving physical forms may include solids, liquids, gasses and any combination thereof. The system and method may include video capturing devices for capturing video footage of the moving forms, a controller for altering the captured video footage of the moving forms, and video projecting devices for projecting the altered video footage back onto the moving forms.

Variable frame rate imaging

An image processing apparatus for processing an image signal, including: an operation processing section performing an operation according to a detected value of the image signal; a latch signal generation section for generating a plurality of latch signals, which indicate a timing of processing for the operation processing section and are based on a plurality of different picture rates applied to the image signal; a latch signal selection section selecting one of the plurality of latch signals inputted from the latch signal generation section and outputting the selected latch signal to the operation processing section; and a latch signal selection indication section indicating to the latch signal selection section a latch signal to be selected from the plurality of latch signals.

Air supply device, gas turbine system and using method thereof

An air supply device, a gas turbine system and a using method thereof are disclosed. In the air supply device, an air intake compartment includes a connection end; a combustion air intake filter is located in the air intake compartment and connected with the combustion air intake filter; a combustion air intake interface is located on a tail plate and is connected with the combustion air silencer; and a sound insulation turnover mechanism includes a sound insulation flap and a turnover mechanism, the air intake compartment includes a first bottom plate and the tail plate that is located at the connection end, the sound insulation flap is located at the connection end, and the turnover mechanism is connected with the sound insulation flap, and is configured to drive the sound insulation flap to rotate relative to the tail plate.

SUPER LOW PRESSURE DROP PACKING SHEET WITH DIVERSION WINDOWS AND ITS STRUCTURED PACKING

A low pressure drop structured packing sheet with diversion windows, which are formed on both crests and troughs. When in the expanded state where the diversion window and packing sheet are flat on the same plane, the diversion window has an opening and a fan-shaped portion, with the area of the opening being 0%-1000% of that of the fan-shaped portion. Two side intersection lines between the fan-shaped portion and packing sheet is symmetrical with respect to a central folding line which divides the fan-shaped portion into a left part and a right part. The two side intersection lines intercept to each other with an angel of about 10°-170°. When in the operating state where the diversion window and packing sheet are partially folded towards opposite directions, the fluid at the trough flows to a crest of the other side of the packing sheet with the help of diversion windows, thus increasing the area of vapor-liquid mass transfer. Additionally, when liquid goes across the diversion window, liquid at the bottom of the layer flow becomes the liquid on the liquid film, hence effectively facilitating update of the liquid film and turbulence, increasing mixture between the liquid and vapor, and improving rate of the mass transfer between vapor and liquid. 1. (canceled)2. (canceled)3. (canceled)4. (canceled)5. A low pressure drop structured packing sheet , comprising a plurality of diversion windows and assuming an expanded state or an operating state , wherein , in said expanded state , said diversion windows and the rest of the packing sheet are on the same plane , each of said diversion windows comprises an opening defined by an upper side and a lower side and a fan-shaped portion , said opening has an area which is 0%-1000% of the area of said fan-shaped portion , said fan-shaped portion has a left part and right part divided by a central folding line and being symmetric with respect to said central folding line , said left part is between said central folding line and a ...

Determining network performance metrics using customer-specific information

Systems and methods are described herein for analyzing the performance of a communications network (e.g., a mobile telecommunications network) using customer-centric and/or subscriber-centric data and information. In some embodiments, the systems and method may determine key performance indicators for a communications network by accessing call detail records from multiple communications network sources, generating a database of one or more customer stats table (CSTs) based on the accessed call records, wherein the CSTs include records for each individual customers of the communications network, and determining one or more key performance indicators (KPIs) for the overall network based on the records stored by the one or more customer stats tables.

B7-H3 antibody, antigen-binding fragment thereof and medical use thereof

A B7-H3 antibody, an antigen-binding fragment thereof and a medical use thereof are provided. Furthermore, a pharmaceutical composition containing the B7-H3 antibody or antigen-binding fragment thereof, and the use thereof as a medicament are provided. In particular, a use of a human B7-H3 antibody or antigen-binding fragment thereof for the manufacture of a medicament for the treatment of a B7-H3-associated disease or condition are described.

Diamino-alkylamino-linked arylsulfonamide compounds with selective activity in voltage-gated sodium channels

Disclosed are compounds of Formula A, or a salt thereof: Formula (A), wherein: Het, Q and R1Ato R4Aare defined herein, which compounds have properties for blocking Nav1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A or their salts, and methods of treating cough, itch, acute pain and neuropathic pain disorders using the same.

Telecommunications network coverage

A system and method for improving network coverage is discussed herein. The system and method can improve network coverage based on lack of coverage key performance indicators generated by disconnection data when user equipment (UE) disconnects from and reconnects to a wireless network. The system determines if the disconnection is associated with a lack of coverage by the wireless network or some other reason. When the disconnection is due to lack of coverage, once the UE reconnects to the wireless network, lack of coverage data associated with the lack of coverage can be used to generate key performance indicators which can be used to improve network coverage. For example, an additional network site can be added to the network, a network site operating parameter can be adjusted, or the like.

DETERMINING NETWORK PERFORMANCE METRICS USING CUSTOMER-SPECIFIC INFORMATION

Systems and methods are described herein for analyzing the performance of a communications network (e.g., a mobile telecommunications network) using customer-centric and/or subscriber-centric data and information. In some embodiments, the systems and method may determine key performance indicators for a communications network by accessing call detail records from multiple communications network sources, generating a database of one or more customer stats table (CSTs) based on the accessed call records, wherein the CSTs include records for each individual customers of the communications network, and determining one or more key performance indicators (KPIs) for the overall network based on the records stored by the one or more customer stats tables. 1. A method for determining key performance indicators (KPIs) for a communications network , the method comprising: 'wherein the accessed call records include individual records for each occurrence of a call, message, and data session within the communications network;', 'accessing call records from multiple communications network sources,'} customer usage data for customers of the communications network,', 'customer profile data for the customers of the communications network, and', 'customer top cell usage data for the customers of the communications network; and, 'wherein the one or more customer stats tables store customer-centric data over a certain period of time, the customer-centric data including, 'generating a database of one or more customer stats table (CSTs) based on the accessed call records,'}determining one or more key performance indicators (KPIs) based on the one or more customer stats tables.2. The method of claim 1 , wherein accessing call records from multiple communications network sources includes accessing call detail records (CDRs) event data records (EDRs) claim 1 , and data logs from components of the communications network.3. The method of claim 1 , wherein generating a database of one or more ...

Method for Managing Application Icon, Terminal Device, and Storage Medium

In the fields of electronic technologies and terminals, a method for managing an application icon, a terminal device, and a storage medium are provided. The terminal device is a smartwatch, a mobile phone, or the like with a display screen and on which an application is installed. In a scenario of installing an application on the terminal device, whether a target closed circle exists in closed circles in a direction from inside to outside in an icon grid is determined, where the icon grid is formed by arranging all current application icons of the terminal device in a grid manner, the closed circles are rectangular circles centered on a center of the icon grid, and a free position for an application icon exists on the target closed circle. If the target closed circle exists, a target application icon is added at the free position on the target closed circle. An icon of a newly installed application is added on an existing incomplete closed circle, to ensure that the application icons remain ...

TIM-3 antibody, antigen binding fragment thereof, and medicinal uses thereof

A TIM-3 antibody, an antigen-binding fragment thereof, and medical uses thereof are described. More specifically, the present invention provides a rat-derived antibody containing a CDR region of the TIM-3 antibody, a chimeric antibody or a human-derived antibody thereof, and a pharmaceutical composition containing the TIM-3 antibody and the antigen-binding fragment thereof, as well as uses thereof serving as a drug. In particular, the present invention provides uses of a human-derived TIM-3 antibody in the preparation of drugs for treating TIM-3-related conditions.

IMAGE PROCESSING APPARATUS, IMAGE PROCESSING METHOD AND PROGRAM

The present invention provides an apparatus and a method to perform an interpolation process of a color mosaic image generated through an imaging process by a single-plate color imaging element. The color mosaic image generated through the imaging process by the single-plate color imaging element is input, estimation is performed for a pixel value low frequency component and a noise high frequency component corresponding to a pixel interpolation position, and calculation for a pixel value at the pixel interpolation position is performed by applying an addition result thereof. An edge-adaptive interpolation processing unit calculates a pixel value at the pixel interpolation position by using a pixel value of a reference pixel located in an edge direction. A blend processing unit calculates a final interpolation pixel value by blending the edge-adaptive interpolation pixel value and the addition result of the pixel value low frequency component and the noise high frequency component corresponding to the pixel interpolation position in accordance with flatness at the pixel interpolation position. 1. An image processing apparatus , comprising;a low frequency component calculation processing unit which receives input of a color mosaic image generated through an imaging process by a single-plate color imaging element and which calculates a pixel value low frequency component corresponding to a pixel interpolation, position;a noise estimating unit which receives input of the color mosaic image and which estimates at noise high frequency component corresponding to the pixel interpolation position; anda blend processing unit which calculates a pixel value at the pixel interpolation position by applying an addition result of the pixel value low frequency component and the noise high frequency component corresponding to the pixel interpolation position.2. The image processing apparatus according to claim 1 , further comprising:a flat part, detecting unit which calculates ...

METHOD OF EPITAXIAL GROWTH EFFECTIVELY PREVENTING AUTO-DOPING EFFECT

This invention relates to a method of epitaxial growth effectively preventing auto-doping effect. This method starts with the removal of impurities from the semiconductor substrate having heavily-doped buried layer region and from the inner wall of reaction chamber to be used. Then the semiconductor substrate is loaded in the cleaned reaction chamber to be pre-baked under vacuum conditions so as to remove moisture and oxide from the surface of said semiconductor substrate before the extraction of the dopant atoms desorbed from the surface of the semiconductor substrate. Next, under high temperature and low gas flow conditions, a first intrinsic epitaxial layer is formed on the surface of said semiconductor substrate where the dopant atoms have been extracted out. Following this, under low temperature and high gas flow conditions, a second epitaxial layer of required thickness is formed on the structural surface of the grown intrinsic epitaxial layer. Last, silicon wafer is unloaded after cooling. This method can prevent auto-doping effect during the epitaxial growth on semiconductor substrate and thus ensure the performance and enhance the reliability of the devices in peripheral circuit region. 1. A method of epitaxial growth effectively preventing auto-doping effect , characterized by comprising the following steps:1) Preparing the semiconductor substrate having heavily-doped buried layer and removing surface oxide from said semiconductor substrate;2) Cleaning the reaction chamber to be used so as to remove impurities from the inner wall of the reaction chamber;3) Loading said semiconductor substrate into the cleaned reaction chamber and pre-baking said semiconductor substrate under vacuum conditions so as to remove moisture and oxide from the surface of said semiconductor substrate before the extraction of the dopant atoms desorbed from the surface of said semiconductor substrate;4) Under high temperature and low gas flow conditions, growing a first intrinsic ...

METHOD FOR PROCESSING TOUCH SCREEN TERMINAL OBJECT AND TOUCH SCREEN TERMINAL

The present invention provides a method for processing a touch screen terminal object and a touch screen terminal. The method includes: receiving an object placing instruction of placing, in a container interface, a source object selected in a source interface, determining, according to attribute information of the source object, a display icon that corresponds to the source object, and displaying, in the container interface, the display icon that corresponds to the source object; receiving an icon placing instruction of placing the display icon that corresponds to the source object and is in the container interface on a selected target object in a target interfac; determining a target operation option according to the attribute information of the source object and attribute information of the target object; and starting a target operation procedure according to the target operation option and the target object. 1. A method for processing a touch screen terminal object , comprising:receiving an object placing instruction given by a user, wherein the object placing instruction is used to place, in a container interface, a source object selected by the user in a source interface, the object placing instruction carries attribute information of the source object, and the source interface is an interface where the source object is located;determining, according to the attribute information of the source object, a display icon that corresponds to the source object, and displaying, in the container interface, the display icon that corresponds to the source object;receiving an icon placing instruction given by the user, wherein the icon placing instruction is used to place the display icon that corresponds to the source object and is in the container interface on a target object in a target interface, the icon placing instruction carries the attribute information of the source object and attribute information of the target object, and the target interface is an interface ...

PHASE CHANGE MEMORY CELL AND FABRICATION METHOD THEREOF

The present invention provides a phase change memory cell and fabrication method thereof, wherein said phase change memory cell comprises a semiconductor substrate, a first electrode layer, a phase change material layer, a second electrode layer and an extraction electrode, as well as a high resistance material layer used to prevent said phase change material layer from over-corrosion during the chemical mechanical polishing process, and wherein said high resistance material layer has a resistance ten or more times that of the phase change material layer and can be used to prevent phase change material layer from over-corrosion during the chemical mechanical polishing process and thus enhance the memory performance and the yield of phase change memory cell. 1. A phase change memory cell , comprising a semiconductor substrate , and a first electrode layer , a phase change material layer and a second electrode layer that are sequentially located on said semiconductor substrate , and an extraction electrode located on said semiconductor substrate; characterized by also comprising a high resistance material layer used to prevent said phase change material layer from over-corrosion during the chemical mechanical polishing process , wherein said high resistance material layer has a resistance ten or more times that of the phase change material layer.2. The phase change memory cell according to claim 1 , characterized in that said high resistance material layer is located between said first electrode layer and said phase change material layer claim 1 , or located on the extraction electrode of said first electrode layer.3. The phase change memory cell according to claim 1 , characterized in that said high resistance material layer is made of any one of the following: simple substance of main group IV claim 1 , V and VI claim 1 , alloy claim 1 , oxide claim 1 , nitride claim 1 , carbide claim 1 , nitrogen oxide.4. The phase change memory cell according to claim 1 , ...

METHOD OF ALLOY SURFACE TREATMENT

A alloy surface treatment includes dewaxing and deoiling to an alloy surface via a cleaning process; sealing holes on the alloy surface with an organic material; forming a first coating on the alloy surface with a UV curing material; providing a plasma treatment to activate the alloy surface, then providing a PVD process to form a second coating outside the alloy; forming a third coating on the alloy surface with another UV curing material which further includes a toner therein, then forming a fourth coating on the alloy surface with the UV curing material, wherein the toner is provided to match the color of hexavalent-chromium to obtain a hexavalent-chromium imitated product. 1. An surface treatment comprising:dewaxing and deoiling to an alloy surface by using of a cleaning process;sealing holes on the alloy surface with an organic material;forming a first coating outside the alloy surface with a first passive curing material;providing a plasma treatment to activate the alloy surface, then providing a PVD process to form a second coating outside the alloy surface;forming a third coating outside the alloy surface with a second passive curing material which further comprises a toner therein, then forming a fourth coating outside the alloy surface with a third passive curing material.2. The surface treatment of claim 1 , wherein the cleaning process is selected from a group consisted of hydrogen-carbon vacuum cleaning claim 1 , dry ice cleaning and factious cleaning.3. The surface treatment of claim 2 , wherein the organic material is related to a silanes fluid.4. The surface treatment of claim 3 , wherein the first claim 3 , second and the third passive material are related to an UV curing paint.5. The surface treatment of claim 4 , wherein the plasma treatment is operated according to the control parameters of that the ion source current is 0.3˜0.5 A; the biasing is 80˜150V; the Mark-Space ratio is 50˜80%; the argon gas flow velocity is 10˜100 SCCM; the oxygen flow ...

IDENTIFYING AND RESOLVING TELECOMMUNICATION NETWORK PROBLEMS USING NETWORK EXPERIENCE SCORE

The disclosed system identifies and resolves telecommunication network problems and/or problems with devices utilizing the network. The system segments the user devices into groups having similar characteristics, by grouping together devices more likely to leave the network, and devices less likely to leave the network. Each group of devices has a trained machine learning model, to predict the NEX score for each device. The system focuses on devices with a low NEX score. The system determines whether the problem is with the network and/or the problem is with the device. The system gathers information from network monitoring software and determine which tower caused, for example, the call to drop. The system determines technological capability of the device from the device TAC number. The system suggests solutions to the network problems by suggesting adding a sector, tuning an antenna, etc., or if the device has problems, adjusting phone settings. 1. A method to identify a problem associated with a telecommunication network or a device using the telecommunication network , the method comprising: wherein the device KPIs comprise at least two of: billing account number (BAN) count, payload usage, voice usage, or tenure,', 'wherein the BAN represents a number of lines one of the multiple devices has registered with the telecommunication network and wherein the tenure represents how long the one device has been using the telecommunication network;, 'obtaining device key performance indicators (KPIs) associated with each of multiple devices using the telecommunication network,'} segmenting the multiple devices into multiple groups having similar device KPIs;', 'obtaining multiple machine learning models, wherein each machine learning model among the multiple machine learning models corresponds to each group among the multiple groups;', 'wherein the network KPIs comprise at least two of: a voice dropped call count, a voice dropped call rate, a low coverage value, a data ...

FEEDING ACCESSORY AND FEEDING ASSEMBLY

Provided are a feeding accessory and a feeding accessory. The feeding accessory includes a nipple cap, a nipple head, a delivery tube, and a blocking member. The nipple cap has a bowl-inverted shape. The nipple head is provided in a center of an outer arc surface of the nipple cap. One end of the delivery tube is provided in a center of an inner arc surface of the nipple cap and is in communication with the cavity of the nipple head. The blocking member is provided with a liquid conducting through hole along a thickness direction of the blocking member, The blocking member is configured to be plugged into an opening of a bottle. At least the nipple cap, the nipple head, and the blocking member are made of silicone. 1. A feeding accessory , comprising:a nipple cap, wherein the nipple cap has a bowl-inverted shape;a nipple head, wherein the nipple head is provided in a center of an outer arc surface of the nipple cap, and the nipple head is provided with a cavity;a delivery tube, wherein one end of the delivery tube is provided in a center of an inner arc surface of the nipple cap and is in communication with the cavity of the nipple head; anda blocking member, wherein the blocking member is provided with a liquid conducting through hole along a thickness direction of the blocking member, the liquid conducting through hole is in communication with the delivery tube, the blocking member is configured be plugged into an opening of a bottle, and the blocking member is connected to another end of the delivery tube;wherein at least the nipple cap, the nipple head, and the blocking member are made of silicone.2. The feeding accessory according to claim 1 , wherein the nipple cap claim 1 , the nipple head claim 1 , the delivery tube claim 1 , and the blocking member are manufactured in one piece by using silicone.3. The feeding accessory according to claim 1 , wherein at least two seal rings are provided on an outer peripheral wall of the blocking member claim 1 , and the at ...

MAGNETIC SENSING APPARATUS, MAGNETIC INDUCTION METHOD AND PREPARATION PROCESS THEREOF

A magnetic sensing apparatus includes a third direction magnetic sensing component. The third direction magnetic sensing component includes: a substrate having groove in its surface; a magnetic conductive unit, and an inducing unit. The main part of the magnetic conductive unit is set in the groove, and a part of it is exposed out the groove and to surface of the substrate, in order to collect magnetic field signal in the third direction and output the magnetic field signal. The inducing unit is disposed on the surface of the substrate, to receive the magnetic field signal in the third direction and measuring corresponding magnetic field strength and direction in the third direction by the magnetic field signal. 2. The magnetic sensing apparatus of claim 1 , wherein: 'the magnetic conductive unit is configured to collect the magnetic field signal in the perpendicular direction and output the magnetic signal;', 'the third direction magnetic sensing component is a perpendicular direction magnetic sensing component;'} 'the magnetic sensing apparatus further comprises a first magnetic sensor, and a second magnetic sensor configured to respectively induce magnetic field in first direction and second direction, and the first direction and the second direction are perpendicular to each other.', 'the inducing unit is a magnetic sensor inducing magnetic field paralleled to the surface of the substrate, sets on the surface of the substrate, and comprises magnetic material layer configured to receive the magnetic field signal in the perpendicular direction from the magnetic conductive unit, and measure corresponding magnetic field strength and direction in the perpendicular direction by the magnetic field signal; the perpendicular direction is perpendicular to the surface of the substrate; and'}3. The magnetic sensing apparatus of claim 1 , wherein:The third direction magnetic sensing component comprises peripheral circuit, to calculate and output magnetic field strength and ...

METHOD AND APPARATUS FOR UPDATING AN APPLICATION IN A USER TERMINAL

The invention discloses a method for updating an application in a user terminal, comprising: acquiring information of an application installed by a user in a terminal; and sending the information of the application installed by the user in the terminal to a server to be stored in an account of the user; wherein the information of the application is used for being pushed by the server to another terminal used by the user. In addition, the invention further discloses an apparatus for updating an application in a user terminal. With the invention, when a user installs a new application and/or updates an installed application in a terminal used by him, the user may be prompted to install and/or update the same application in other terminal used by him. 1. A method for updating an application in a user terminal , comprising:acquiring information of an application installed by a user in a terminal; andsending the information of the application installed by the user in the terminal to a server to be stored in an account of the user;wherein the information of the application is used for being pushed by the server to another terminal used by the user.2. The method as claimed in claim 1 , further comprising:acquiring information of the operating system used in the terminal;accordingly, the step of sending the information of the application installed by the user in the terminal to a server to be stored in an account of the user is to,send the information of the application installed by the user in the terminal and the information of the operating system used by the terminal to the server and store them in the account of the user,wherein in the account registered by the user with the server are stored the information of the operating system and the download and installation addresses of individual applications used by the user under the operating system respectively.3. The method as claimed in claim 2 , wherein before acquiring the information of the application installed by ...

FACTOR IXa INHIBITORS

In its many embodiments, the present invention provides a novel class of benzamide compounds represented by Formula (I) or pharmaceutically acceptable salts or solvates thereof, or pharmaceutical compositions comprising one or more said compounds or pharmaceutically acceptable salts or solvates thereof, and methods for using said compounds or pharmaceutically acceptable salts or solvates thereof for treating or preventing a thromboses, embolisms, hypercoagulability or fibrotic changes. 2. A compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein p is an integer of 0 to 1.3. A compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein q is an integer of 0 to 2.4. A compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein r is an integer of 0 to 2.10. A compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein: Ris a halogen atom claim 1 , a cyano group claim 1 , or a Calkyl group.11. A compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein: Ris a halogen atom.12. A compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein: Ris a cyano group claim 1 , a Calkyl group claim 1 , a halogenated Calkyl group claim 1 , a hydroxy Calkyl group claim 1 , a Calkoxy group or oxo.13. A compound of claim 6 , or a pharmaceutically acceptable salt thereof claim 6 , wherein: Ris a Calkyl group claim 6 , a halogenated Calkyl group or a hydroxyl Calkyl group.14. A compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , which isN-((1S*,4S*,7R*)-2-(3-Aminobenzo[d]isoxazol-7-yl)-2-azabicyclo[2.2.1]heptan-7-yl)-2-chloro-4-(4H-1,2,4-triazol-4-yl)benzamide;N-((1S*,4S*,7R*)-2-(3-Aminoisoxazolo[5,4-c]pyridin-7-yl)-2-azabicyclo[2.2.1]heptan-7-yl)-2-chloro-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzamide;N-((1S*,4S*,7R*)-2-(3-Amino-5-methylbenzo[d]isoxazol-7-yl)-2-azabicyclo[2.2.1]heptan-7-yl)-2,6-dichloro-4-( ...

TRAVEL ASSISTING METHOD AND TERMINAL

An embodiment of the present invention discloses a travel assisting method, including: extracting trip information from content saved in a terminal and saving the extracted trip information in a trip list; selecting the trip information from the trip list, automatically connecting to a preset network address or a preset server address, and searching by using part or all of content of each piece of the selected trip information as a key word, so as to obtain assisting information corresponding to the trip information; and generating prompting information. Correspondingly, an embodiment of the present invention further discloses a terminal. The present invention enables the terminal to automatically provide effective reference information for a user according to a trip of the user, solving the problem that an operation is troublesome and time-consuming when the user obtains trip-related assisting information by using the terminal. 1. A travel assisting method , comprising:extracting trip information from content saved in a terminal and saving the extracted trip information in a trip list, wherein the trip information is travel-related information and the trip list is used to save the trip information;selecting the trip information from the trip list, automatically connecting to a preset network address or a preset server address, and searching by using part or all of content of each piece of the selected trip information as a key word, so as to obtain assisting information corresponding to the trip information; andgenerating prompting information which comprises the trip information and the assisting information corresponding to the trip information.2. The method according to claim 1 , wherein the content saved in the terminal comprises content saved in a storage space corresponding to any or more of the following applications: a calendar claim 1 , events claim 1 , a memo claim 1 , an Email claim 1 , a multimedia message claim 1 , and a short message.3. The method ...

PAPILLOMAVIRUS CHIMERIC PROTEIN AND APPLICATION THEREOF

Provided is a papillomavirus chimeric protein, the skeleton thereof being a papillomavirus L1 protein or a mutant thereof, at least one human papillomavirus 33-type L2 protein or mutant polypeptide thereof being embedded on the skeleton. The present papillomavirus chimeric protein can be used for preparing a vaccine for preventing papillomavirus infections and infection induced disease. 1. A chimeric papillomavirus protein comprising papillomavirus L1 protein or a mutant of papillomavirus L1 protein as scaffold , characterized in that , at least one polypeptide derived from HPV33 L2 protein or from a mutant of HPV33 L2 protein is inserted into said scaffold.2. The chimeric papillomavirus protein according to claim 1 , characterized in that claim 1 , said polypeptide is derived from any fragment of the consecutive 8-33 amino acids within aa. 1-200 of the HPV33 L2 protein claim 1 , preferably claim 1 , the amino acid sequence of said polypeptide is shown as SEQ ID No.1; or claim 1 , said polypeptide is a polypeptide obtained by extending or truncating 1-5 amino acids from the sequence shown as SEQ ID No.1 at N-terminus and/or C-terminus; preferably claim 1 , the amino acid sequence of said polypeptide is shown as SEQ ID No. 2 or SEQ ID No.3.3. The chimeric papillomavirus protein according to claim 1 , characterized in that claim 1 , the scaffold is HPV16 L1 protein or a mutant of the HPV16 L1 protein; preferably claim 1 , the mutant of the HPV16 L1 protein is obtained by truncating 0-9 amino acids at the N-terminus and/or 0-34 amino acids at the C-terminus from the HPV16 L1 protein; more preferably claim 1 , the amino acid sequence of the scaffold is shown as SEQ ID No.4 or the amino acid sequence of SEQ ID No.4 with 31 amino acid deletion at the C-terminus.4. The chimeric papillomavirus protein according to claim 3 , characterized in that claim 3 , the HPV33 L2 protein-derived polypeptide is inserted into the surface region of the HPV16 L1 protein or of the mutant of ...

Milk suction and collection device

Disclosed is a milk suction and collection device integrally manufactured and formed by silicone. The milk suction and collection device includes a main body which is hollow inside to define a milk storage chamber and is further provided with a milk pouring port operative to be selectively blocked. A breast protecting film is provided on a side in a thickness direction of the main body and is configured to be fitted with an outer periphery of a breast, and is further provided with a milk collecting port communicating with the milk storage chamber. The side of the main body of the milk suction and collection device provided with the breast protecting film is operative to be fitted with the breast because the milk suction and collection device is integrally manufactured and formed by silicone. When the milk pouring port is closed, a breast pumping function is achieved by squeezing the main body. When the milk pouring port is opened, a milk collecting function is achieved.

B7-H3 ANTIBODY, ANTIGEN-BINDING FRAGMENT THEREOF AND MEDICAL USE THEREOF

A B7-H3 antibody, an antigen-binding fragment thereof and a medical use thereof are provided. Furthermore, a pharmaceutical composition containing the B7-H3 antibody or antigen-binding fragment thereof, and the use thereof as a medicament are provided. In particular, a use of a human B7-H3 antibody or antigen-binding fragment thereof for the manufacture of a medicament for the treatment of a B7-H3-associated disease or condition are described. 1. A monoclonal anti-B7-H3 antibody or antigen-binding fragment thereof , which binds to human B7-H3 , comprising:(i)an antibody heavy chain variable region comprising HCDR1, HCDR2, and HCDR3 having the amino acid sequences of SEQ ID NOs: 10, 11 and 12, respectively; andan antibody light chain variable region comprising LCDR1, LCDR2, and LCDR3 having the amino acid sequences of SEQ ID NOs: 13, 14 and 15, respectively; or(ii)an antibody heavy chain variable region comprising HCDR1, HCDR2, and HCDR3 having the amino acid sequences of SEQ ID NOs: 16, 17 and 18, respectively; andan antibody light chain variable region comprising LCDR1, LCDR2, and LCDR3 having the amino acid sequences of SEQ ID NOs: 19, 20 and 21, respectively.2. The monoclonal anti-B7-H3 antibody or antigen-binding fragment thereof according to claim 1 , wherein the monoclonal antibody is a recombinant antibody.3. The monoclonal anti-B7-H3 antibody or antigen-binding fragment thereof according to claim 2 , wherein the monoclonal antibody is a human recombinant antibody or antigen-binding fragment thereof.4. The monoclonal anti-B7-H3 antibody or antigen-binding fragment thereof according to claim 3 , wherein the framework (FR) sequences of the light chain and heavy chain variable regions of the human recombinant antibody are derived from a human germline light chain and heavy chain claim 3 , respectively claim 3 , or mutant sequences thereof.5. The monoclonal anti-B7-H3 antibody or antigen-binding fragment thereof according to claim 4 , wherein the human ...

2-(3,4-DIHYDROXYPHENYL)ETHYL 3-HYDROXYBUTANOATE, COMPOSITION, AND METHOD FOR IMPROVING FUNCTION OF AORTIC ENDOTHELIAL CELL

The disclosure relates to a compound, 2-(3,4-dihydroxyphenyl)ethyl 3-hydroxybutanoate, for improving aortic endothelial cell function and use thereof. The compound is capable of inhibiting inflammatory response of the human aortic endothelial cells caused by a saturated fatty acid, and preventing an occurrence and progression of atherosclerosis. The compound is capable of reducing human aortic endothelial inflammation caused by a saturated fatty acid, for example, reducing the mRNA levels of interleukin-6 (IL-6), and is capable of effectively protecting the function of mitochondria in human aortic endothelium from being damaged by a saturated fatty acid, for example, increasing the expression of mitochondrial complex I. 1. A compound , 2-(3 ,4-dihydroxyphenyl)ethyl 3-hydroxybutanoate.24-. (canceled)5. A method for improving function of an aortic endothelial cell claim 1 , the method comprising contacting the cell with an effective amount of the compound of .6. A method for inhibiting saturated fatty acid induced inflammation of an aortic endothelial cell claim 1 , the method comprising contacting the cell with an effective amount of the compound of .7. A method for reducing a mRNA level corresponding to interleukin-6 (IL-6) in an aortic endothelial cell claim 1 , the method comprising contacting the cell with an effective amount of the compound of .8. A method for protecting a mitochondrion from being damaged by saturated fatty acid induced inflammation of an aortic endothelial cell claim 1 , the method comprising contacting the cell with an effective amount of the compound of .9. A method for increasing an expression of mitochondrial complex I protein in an aortic endothelial cell claim 1 , the method comprising contacting the cell with an effective amount of the compound of .10. (canceled)11. A method for preventing atherosclerosis claim 1 , the method comprising administering to a patient in need thereof a therapeutically effective amount of the compound of .1214 ...

METHOD FOR TREATING MELANOMA

Disclosed is a method of inhibiting growth of a melanoma cancer cell. The method includes contacting the melanoma cancer cell with an effective amount of a composition and the composition contains polymethoxyflavone. The polymethoxyflavone can be applied in an amount of 0.1 μmol/L-1000 μmol/L. A method of treating a subject having melanoma with the above discussed composition is also included. 1. A method of inhibiting growth of a melanoma cancer cell , the method comprising contacting the melanoma cancer cell with an effective amount of a composition , wherein the composition comprises polymethoxyflavones.2. The method of claim 1 , wherein the polymethoxyflavone is hesperetin claim 1 , nobiletin claim 1 , sinensetin claim 1 , hesperidin claim 1 , tangeretin claim 1 , 3 claim 1 ,5 claim 1 ,6 claim 1 ,7 claim 1 ,3′ claim 1 ,4′-hexamethoxyflavone claim 1 , 3 claim 1 ,5 claim 1 ,6 claim 1 ,7 claim 1 ,8 claim 1 ,3′ claim 1 ,4′-heptamethoxyflavone claim 1 , 3 claim 1 ,5 claim 1 ,7 claim 1 ,3′ claim 1 ,4′-pentamethoxyflavone claim 1 , 5 claim 1 ,6 claim 1 ,7 claim 1 ,4′-tetramethoxyflavone claim 1 , 5-hydroxy-6 claim 1 ,7 claim 1 ,8 claim 1 ,3′ claim 1 ,4′-pentamethoxyflavone claim 1 , 5-hydroxy-6 claim 1 ,7 claim 1 ,8 claim 1 ,4′-tetramethoxyflavone claim 1 , 5-hydroxy-6 claim 1 ,7 claim 1 ,3′ claim 1 ,4′-tetramethoxyflavone claim 1 , gardenin claim 1 , 5-hydroxy-3 claim 1 ,6 claim 1 ,7 claim 1 ,8 claim 1 ,3′ claim 1 ,4′-hexamethoxyflavone claim 1 , 5-hydroxy-3 claim 1 ,6 claim 1 ,7 claim 1 ,3′ claim 1 ,4′-pentamethoxyflavone claim 1 , 5-hydroxy-6 claim 1 ,7 claim 1 ,4′-trimethoxyflavone claim 1 , or a combination thereof.3. The method of claim 2 , wherein the polymethoxyflavone is 5-hydroxy-3 claim 2 ,6 claim 2 ,7 claim 2 ,8 claim 2 ,3′ claim 2 ,4′-hexamethoxyflavone.4. The method of claim 1 , wherein the polymethoxyflavone is applied in an amount of 0.1 μmol/L-1000 μmol/L.5. The method of claim 1 , wherein the melanoma cancer cell is human melanoma cancer cell A2058 or ...

Residue removing device and 3d printer

The present invention provides a residue removing device for removing residues in a partition plate, and a related 3D printer for use on a working platform. The partition plate e.g. of a 3D printer has a plurality of openings arranged in an array, and residues may be filled in the openings. The residue removing device includes a base plate and a plurality of jutting pins disposed on an upper side of the base plate. The jutting pins are arranged in an array corresponding to the openings array such that the jutting pins are capable of being inserted into the openings, in order to easily remove the residues in the openings of the partition plate.

LOCATION ADJUSTMENT METHOD AND APPARATUS FOR CONTROL IN APPLICATION, DEVICE, AND STORAGE MEDIUM

A location adjustment method and apparatus provide for improved control. In a virtual environment picture, a temporary entry control and a function prompt information about location customization are displayed. A location adjustment operation is triggered on the temporary entry control, and a drag operation on the temporary entry control is provided in an editing state, with the temporary entry control dragged from a first location to a second location. The temporary entry control is displayed at the second location. When the temporary entry control is displayed for the first time, a location of the temporary entry control is adjusted by directly dragging the temporary entry control, which simplifies location adjustment and improves efficiency. 1. A location adjustment method comprising:displaying a virtual environment picture acquired from a virtual environment, a temporary entry control being displayed at a first location on the virtual environment picture;displaying function prompt information on the virtual environment picture when the temporary entry control is displayed for a first time, the function prompt information being configured for prompting that the temporary entry control has a location customization function;receiving a location adjustment operation triggered on the temporary entry control;displaying the temporary entry control in an editing state;receiving a drag operation on the temporary entry control in the editing state where the temporary entry control is dragged from the first location to a second location; anddisplaying the temporary entry control at the second location on the virtual environment picture in response to the drag operation.2. The method according to claim 1 , wherein the receiving a location adjustment operation claim 1 , and the displaying the temporary entry control in an editing state further comprises:receiving the location adjustment operation and acquiring historical running information; anddisplaying the temporary entry ...

MOBILE POWER SYSTEM

The present invention discloses a mobile power system, the whole mobile power system is assigned onto two transport vehicles, achieving effective integration to reduce transport vehicle and transport cost; the two transport vehicles are connected at the side to enable quick and convenient connection in working state, greatly saving installation time; a gas turbine starter is disposed on an exhaust auxiliary transportation unit so that the mobile power system can be started by a gas turbine in totally power failure conditions. 1. A mobile power system , comprising a turbine generation transportation unit and an exhaust auxiliary transportation unit , the exhaust auxiliary transportation unit is connected to at least one side of the turbine generation transportation unit , the turbine generation transportation unit comprises an air intake system , a gas turbine , a generator and a first transport vehicle , the gas turbine converts hydrocarbon fuels into mechanical energy of an output shaft , the air intake system is connected to the intake port of the gas turbine through an intake joint , and the intake joint adopts a straight-through joint to supply combustion-supporting air for the conversion process; the generator is disposed at an output end of the gas turbine to convert mechanical energy into required electrical energy; the exhaust auxiliary transportation unit comprises an exhaust system , a cabin ventilation and cooling system and a second transport vehicle , the exhaust system and the cabin ventilation and cooling system are disposed on the second transport vehicle , the exhaust system is connected to an exhaust port of the gas turbine , the cabin ventilation and cooling system is connected to the cabin of the gas turbine ,wherein the exhaust auxiliary transportation unit comprises a gas turbine starter, the gas turbine starter is disposed on the second transport vehicle, the gas turbine starter is used to start the gas turbine by the mobile power system in ...

3,4-DIHYDROXYPHENETHYL 3-HYDROXYBUTANOATE, PREPARATION AND USE THEREOF

The present disclosure discloses a novel compound, 3,4-dihydroxyphenethyl 3-hydroxybutanoate, a method for preparing the same and use of the same, and in particular, a compound of formula I, use of the compound of formula I, optically pure isomers of the compound, a mixture of enantiomers in any ratio, or pharmaceutically acceptable salts thereof in preparing health food and drug for relieving brain fatigue, improving learning and memory abilities, and ameliorating mania mood related to brain fatigue. 2. A method for preparing the compound of claim 1 , the method comprising:S1, synthesizing β-benzyloxybutyric acid;S2, synthesizing 3,4-dibenzyloxyphenylethanol;S3, synthesizing 3,4-bis(benzyloxy)phenethyl 3-(benzyloxy)butanoate; andS4, synthesizing 3,4-dihydroxyphenethyl 3-hydroxybutanoate.3. The method of claim 2 , wherein the step S1 comprises reacting crotonic acid with benzyl alcohol to synthesize β-benzyloxybutyric acid;the step S2 comprises reacting 3,4-dihydroxyphenylethanol with benzyl bromide to synthesize 3,4-dibenzyloxyphenylethanol;the step S3 comprises reacting β-benzyloxybutyric acid synthesized in the step S1 with 3,4-dibenzyloxyphenylethanol synthesized in the step S2 to synthesize 3,4-bis(benzyloxy)phenethyl 3-(benzyloxy)butanoate; andthe step S4 comprises reacting 3,4-bis(benzyloxy)phenethyl 3-(benzyloxy)butanoate synthesized in the step S3 with anhydrous methanol.4. The method of claim 2 , wherein the step S1 comprises:weighing and placing crotonic acid in a first reaction vessel, to which benzyl alcohol and mercuric acetate are sequentially added to form a first mixture, and stirring the first mixture at room temperature overnight;cooling the first reaction vessel to about 0° C., adding sodium hydroxide within about 5 minutes to about 10 minutes to the first reaction vessel, then adding a sodium hydroxide water solution containing sodium borohydride to the first reaction vessel, and keeping the first reaction vessel at about 0° C. for about 3 ...

Inhibitors Targeting the DNA-Binding Domain of Human STAT3 for Treatment of Metastatic Cancers

The present invention provides STAT3 inhibitors which preferentially suppress proliferation of cancer over non-cancer cells and inhibit migration and invasion of malignant cells. The inhibitors of the present invention selectively inhibit STAT3 binding to DNA without affecting the activation and dimerization of STAT3. Furthermore, the inhibitors of the present invention inhibit expression of STAT3 downstream target genes and STAT3 binding to chromatin in situ. 1. A pharmaceutical composition comprising(a) a pharmaceutically effective amount of an inhibitor of signal transducer and activator of transcription 3 (STAT3), or its pharmaceutically acceptable salt or a solvate thereof, and(b) a pharmaceutically suitable carrier.2. The composition of claim 1 , wherein the inhibitor targets the DNA binding domain of STAT3.3. The composition of claim 2 , wherein the inhibitor inhibits the DNA-binding activity of STAT3 with an ICof no greater than 50 μM measured by electrophoretic mobility shift assay (EMSA).4. The composition of claim 1 , wherein the inhibitor is 4-[(3E)-3-[(4-nitrophenyl)-methylidene]-2-oxo-5-phenylpyrrol-1-yl]benzoic acid (inS3-54).5. The composition of claim 4 , wherein the inhibitor is an analogue of inS3-54.6. The composition of claim 5 , wherein the inhibitor is selected from the group consisting of analogues 1 claim 5 , 13 claim 5 , 18 claim 5 , 20 claim 5 , 26 claim 5 , 27 claim 5 , 36 claim 5 , 41 claim 5 , 45 claim 5 , 51 claim 5 , 68 claim 5 , 69 claim 5 , 72 claim 5 , 75 and 79 as shown on Table 3.11. A method of treating cancer claim 1 , the method comprising the step of administering a therapeutically effective amount of the composition of to a subject in need thereof claim 1 , wherein the cancer is treated.12. The method of claim 11 , wherein the cancer is selected from the group consisting of breast and lung cancer.13. The method of claim 11 , wherein the inhibitor is formulated in an oral claim 11 , topical claim 11 , transdermal claim 11 , ...

N1-PHENYLPROPANE-1,2-DIAMINE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS

Disclosed are compounds of Formula A-1, or a salt thereof: Formula A-1, where J, K, Q and R1 are as defined herein, which compounds have properties for inhibiting sodium ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A-1 or their salts, and methods of treating pain (e.g. chronic pain), or cough or itch disorders using the same. 2) A compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein one K is selected to be a linear claim 1 , branched claim 1 , or cycloalkyl comprising up to 6 carbon atoms claim 1 , which alkyl is partially or fully deuterated.4) A compound of claim 3 , or a pharmaceutically acceptable salt thereof claim 3 , wherein Jis a branched alkyl of up to 5 carbon atoms or a cyclic alkyl of up to 5 carbon atoms which is substituted on a ring carbon thereof with a linear claim 3 , branched claim 3 , or cycloalkyl moiety comprising up to 6 carbon atoms.5) A compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein Q is —(C═CF)—.6) A compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein Q is —(C═CH)—.7) A compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein Q is —(C═N)—.8) A compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein Ris Cl.9) A compound which is:(S)-5-chloro-2-fluoro-4-((2-(methylamino)-3-phenylpropyl)amino)-N-(thiazol-2-yl)benzenesulfonamide;(S)-5-chloro-2-fluoro-4-((2-(methylamino)-3-phenylpropyl)amino)-N-(1,2,4-thiadiazol-5-yl)-benzenesulfonamide;(S)-5-chloro-2-fluoro-N-(5-fluorothiazol-2-yl)-4-((2-(methylamino)-3-phenylpropyl)amino)-benzenesulfonamide;(S)-5-chloro-2-fluoro-4-((3-(4-fluorophenyl)-2-(methylamino)propyl)amino)-N-(thiazol-2-yl)benzenesulfonamide;(S)-5-chloro-4-((3-cyclohexyl-2-(methylamino)propyl)amino)-2-fluoro-N-(thiazol-2-yl)benzenesulfonamide;(S)-5-chloro-2-fluoro-4-((2-( ...

Semiconductor structure and fabrication method thereof

A semiconductor structure and its fabrication method are provided in the present disclosure. The method includes providing a base substrate, forming a plurality of discrete core layers on the base substrate, forming an isolation layer on a top surface of a core layer, forming a sacrificial layer on the base substrate and exposing a top surface of the isolation layer, removing the isolation layer after forming the sacrificial layer, removing the sacrificial layer after removing the isolation layer, forming a mask layer on a sidewall surface of the core layer after removing the sacrificial layer, and removing the core layer after forming the mask layer.

MULTIMODAL IMAGE PERCEPTION SYSTEM AND METHOD

A real-time multimodal image perception system to transform the standard lab blood smear image for persons with BVI to perceive, employing a combination of auditory, haptic, and vibrotactile feedbacks. These sensory feedbacks are used to convey visual information in appropriate perceptual channels, thus creating a palette of multimodal, sensorial information. A Bayesian network is provided to characterize images through two groups of features of interest: primary and peripheral features. A method is provided for optimal matching between primary features and sensory modalities. 1. A method for enabling visually impaired users to interpret data , comprising:receiving an input image using a computer processor;receiving a navigation command from a visually impaired user;extracting a plurality of features from the input image to acquire at least one extracted image feature based on the navigation command using the processor;developing a Bayesian network using the processor, the Bayesian network is configured to characterize the input image through the two groups of features of interest, the features comprising primary features and peripheral features; andoutputting an expression of the plurality of features through a plurality of sensory modalities to allow a visually-impaired user to interpret the image features.2. The method of claim 1 , wherein the plurality of features comprises image location claim 1 , intensity claim 1 , texture claim 1 , shape color claim 1 , size claim 1 , and opacity.3. The method of claim 1 , wherein the at least one modality comprises auditory claim 1 , haptic claim 1 , and vibrotactile.4. The method of claim 1 , wherein a linear assignment problem is utilized to assign the image features to the plurality of sensory modalities.5. The method of claim 1 , wherein a quadtratic assignment problem is utilized to assign the image features to the plurality of sensory modalities.6. The method of claim 1 , wherein the plurality of output devices ...

B7-H3 Antibody, Antigen-Binding Fragment Thereof And Medical Use Thereof

A B7-H3 antibody, an antigen-binding fragment thereof and a medical use thereof are provided. Furthermore, a pharmaceutical composition containing the B7-H3 antibody or antigen-binding fragment thereof, and the use thereof as a medicament are provided. In particular, a use of a human B7-H3 antibody or antigen-binding fragment thereof for the manufacture of a medicament for the treatment of a B7-H3-associated disease or condition are described. 1. A method for treating a disease related to a B7-H3 positive cell , wherein the method comprises administering to a subject in need thereof a pharmaceutical composition comprising a therapeutically effective amount of a monoclonal anti-B7-H3 antibody or antigen-binding fragment thereof comprising:(i) an antibody heavy chain variable region comprising HCDR1, HCDR2, and HCDR3 having the amino acid sequences of SEQ ID NOs: 10, 11 and 12, respectively; and an antibody light chain variable region comprising LCDR1, LCDR2, and LCDR3 having the amino acid sequences of SEQ ID NOs: 13, 14 and 15, respectively; or(ii) an antibody heavy chain variable region comprising HCDR1, HCDR2, and HCDR3 having the amino acid sequences of SEQ ID NOs: 16, 17 and 18, respectively; and an antibody light chain variable region comprising LCDR1, LCDR2, and LCDR3 having the amino acid sequences of SEQ ID NOs: 19, 20 and 21, respectively.2. The method according to claim 1 , wherein the monoclonal antibody is a recombinant antibody.3. The method according to claim 1 , wherein the monoclonal antibody is a human recombinant antibody or antigen-binding fragment thereof4. The method according to claim 3 , wherein the human recombinant antibody or antigen-binding fragment thereof comprises a human germline light chain framework (FR) sequence or a modified human germline light chain FR sequence claim 3 , and a human germline heavy chain FR sequence or a modified human germline heavy chain FR sequence.5. The method according to claim 4 , wherein the human ...

Performance-Based Optimization of QoS Factors

Described herein are one or more self-organizing network (SON) components configured to determine QoS factors associated with QoS classes for a node of a telecommunication network based at least in part on performance metrics, network configuration, or network fault information. The one or more SON components may receive the performance metrics, network configuration, or network fault information from the node, and the performance metrics, network configuration, or network fault information may be associated with communication of traffic of the QoS classes by the node. Upon determining the QoS factors, the one or more SON components may transmit indications of the QoS factors to the node.

DEVICE AND METHOD FOR NOZZLE ADJUSTMENT

A nozzle adjustment device for a three-dimensional forming equipment assembly includes a first guiding block, a second guiding block, and a moving block. The first guiding block has a first inclined surface and a first bottom surface which is parallel to a printing platform. The first inclined surface and the first bottom surface form an acute angle therebetween. The second guiding block has a second inclined surface. The moving block is located between the first guiding block and the second guiding block. The moving block has a third inclined surface, a fourth inclined surface, and a second bottom surface. The second bottom surface is parallel to the printing platform, and has a nozzle disposed thereon. 1. A nozzle adjustment device for a three-dimensional forming equipment assembly , the nozzle adjustment device comprising:a first guiding block having a first inclined surface and a first bottom surface which is parallel to a printing platform, the first inclined surface and the first bottom surface forming an acute angle therebetween;a second guiding block having a second inclined surface; anda moving block located between the first guiding block and the second guiding block, the moving block having a third inclined surface, a fourth inclined surface, and a second bottom surface which is parallel to the printing platform and has a nozzle disposed thereon.2. The nozzle adjustment device of claim 1 , wherein the first inclined surface claim 1 , the second inclined surface claim 1 , the third inclined surface claim 1 , and the fourth inclined surface are parallel to each other claim 1 , and the third inclined surface contacts the first inclined surface claim 1 , and the fourth inclined surface contacts the second inclined surface.3. The nozzle adjustment device of claim 1 , further comprising a position-limiting device configured to limit a shortest limiting distance between the second bottom surface of the moving block and the printing platform.4. The nozzle ...

SYSTEM FOR PROVIDING MOBILE POWER

The present invention discloses a system for providing mobile power, in which the required equipment for the power supply system at fracturing fields as well as connection cables and connection hoses are integrated properly, assigned onto three transport vehicles for movement and effectively connected. Intake components and a turbine generation system are combined on a first transport vehicle and installed together, then transported to customer sites directly, thus saving the installation time at the user sites. The two different designs on the locations of an exhaust stack and an exhaust silencer not only meet the requirements of road transportation, but also meet the requirements of exhaust gas emission during operations. 1. A system for providing mobile power , comprising a turbine generation transportation unit , an exhaust transportation unit and an auxiliary system transportation unit ,wherein the auxiliary system transportation unit and the exhaust transportation unit are connected to at least one side of the turbine generation transportation unit;the turbine generation transportation unit comprises intake components, a gas turbine, a generator and a first transport vehicle, and the intake components, the gas turbine and the generator are connected in sequence and disposed on the first transport vehicle;the intake components are configured to filter combustion air to the gas turbine; andthe intake components are disposed on a travel direction end of the first transport vehicle and are connected to the gas turbine through intake joints.2. The system for providing mobile power according to claim 1 , wherein the intake components comprise an intake silencer and an intake filter.3. The system for providing mobile power according to claim 1 , wherein the turbine generation transportation unit further comprises an electric power unit and a control system claim 1 , the electric power unit is configured to output electric power from the generator claim 1 , and the ...

FACTOR IXa INHIBITORS

In its many embodiments, the present invention provides a novel class of benzamide compounds represented by Formula (I) or pharmaceutically acceptable salts or solvates thereof, or pharmaceutical compositions comprising one or more said compounds or pharmaceutically acceptable salts or solvates thereof, and methods for using said compounds or pharmaceutically acceptable salts or solvates thereof for treating or preventing a thromboses, embolisms, hypercoagulability or fibrotic changes.

Substituted aryl ether compound, preparation method thereof, pharmaceutical composition and use thereof

The present invention relates to a compound having the following formula, or a stereoisomer thereof, a prodrug thereof, a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate thereof, preparation method thereof, pharmaceutical composition comprising the same and use of the compound in the manufacture of a medicament for preventing or treating tumor, wherein the substituents are as defined in the specification.

METHOD, APPARATUS AND SYSTEM FOR REMOTELY CONTROLLING ELECTRONIC APPARATUS

A method, an apparatus, and a system for remotely controlling an electronic apparatus are provided. In the method, a control apparatus discovers at least one response apparatus in the same network and obtains an apparatus description of each response apparatus. According to a command list in the apparatus description, the control apparatus sends a control message requesting a service in the command list to the response apparatus, so as to control the response apparatus to execute an operation corresponding to the control message. Here, the command list records a plurality of services provided by the response apparatus. 1. A method for remotely controlling an electronic apparatus , adapted to a control apparatus controlling at least one response apparatus to execute an operation , comprising:discovering the at least one response apparatus in a same network;obtaining an apparatus description of each of the at least one response apparatus; andaccording to a command list in the apparatus description, sending a control message requesting a service in the command list to each of the at least one response apparatus, so as to control the response apparatus to execute the operation corresponding to the control message, wherein the command list records a plurality of services provided by the response apparatus.2. The method as recited in claim 1 , wherein the step of discovering the at least one response apparatus in the same network comprises:broadcasting a search message;receiving an inspection message sent by each of the at least one response apparatus in response to the search message; andestablishing a data connection to a corresponding response apparatus of the at least one response apparatus according to an IP address in the inspection message.3. The method as recited in claim 2 , wherein the step of obtaining the apparatus description of each of the at least one response apparatus comprises:obtaining a web address of the apparatus description from the inspection ...

Terminal Backup and Recovery Method

The invention discloses a terminal backup and recovery method. When in backup, a user interface is provided at a terminal side first, so as to provide, according to a preset display policy, different backup categories for a user to select, wherein the different backup categories comprise different backup objects. Then, according to a backup category and object selected by the user, at the terminal side, a terminal file corresponding to the backup object is backed up at a cloud server according to a preset backup policy. When in recovery, according to a recovery category and object selected by the user, a file already backed up by the terminal/user and corresponding to the backup object is determined at the cloud server, and according to a preset recovery policy, corresponding recovery is executed at the terminal side by using the backed-up file. The invention provides classified backup and recovery, and increases the speed of backup and recovery. 1. A terminal backup method comprising:providing a user interface at a terminal side, so as to provide, according to a preset display policy, different backup categories for a user to select, wherein the different backup categories contain different backup objects;backing up, according to a backup category selected by the user, at the terminal side, a backup object contained in the backup category to a cloud server.2. The terminal backup method as claimed in claim 1 , wherein the backup category comprises a current system claim 1 , an application claim 1 , or user data related with an application claim 1 , whereina backup object contained in the backup category of current system comprises an installed application and a core file of the operating system;a backup object contained in the backup category of application comprises an application already installed at the terminal; anda backup object contained in the backup category of user data related with an application comprises a user data file of the application.3. The ...

Diamino-alkylamino-linked arylsulfonamide compounds with selective activity in voltage-gated sodium channels

Disclosed are compounds of Formula A, or a salt thereof: Formula (A), wherein: Het, Q and R 1A to R 4A are defined herein, which compounds have properties for blocking Na v 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A or their salts, and methods of treating cough, itch, acute pain and neuropathic pain disorders using the same.

METHODS AND APPARATUSES FOR CLUSTER SWITCHING

Apparatuses and methods are disclosed for cluster switching. An exemplary method may include synchronizing original data on a first cluster to a second cluster after starting to switch clusters. A priority of the original data on the second cluster is set to a lower priority. The method may also include responding to a write operation request on the second cluster in the period of synchronizing the original data on the first cluster to the second cluster. A priority of new data corresponding to the write operation request is set to a higher priority. A version of data with a higher priority can overwrite another version of data. The method may further include responding to the write operation request on the second cluster after synchronizing the original data on the first cluster to the second cluster. 1. A method for cluster switching , comprising:Synchronizing original data to be synchronized on a first cluster to a second cluster after starting to switch from the first cluster to the second cluster, wherein the original data on the second cluster is set to have a lower priority;responding to a write operation request on the second cluster in the period of synchronizing the original data on the first cluster to the second cluster, wherein data corresponding to the write operation request is set to have a higher priority, and wherein a version of data with a higher priority is allowed to overwrite another version of data with a lower priority on the second cluster; andresponding to the write operation request on the second cluster after synchronizing the original data on the first cluster to the second cluster.2. The method of claim 1 , wherein: 'responding to a read operation request on the first cluster and the second cluster, and', 'in the period of synchronizing the original data on the first cluster to the second cluster, the method further comprises 'responding to the read operation request on the second cluster.', 'after synchronizing the original data on ...

SORTING AND BUNDLING ALL-IN-ONE MACHINE AND BANKNOTE STACKING AND SORTING MODULE THEREOF

A banknote stacking and sorting module comprises a banknote clamping and conveying sub-module, which comprises a clamping mechanism and a vertical reciprocating mechanism thereof. Clamping mechanism comprises bearing plate, support, cam, clamping rod and clamping spring. Cam is rotatably mounted on support. Clamping rod comprises clamping end, transmission end and hinged part between clamping end and transmission end. Hinged part of clamping rod is hinged on support. Cam engages with transmission end of clamping rod and can drive clamping rod in rotation around second rotary shaft between released position and clamped position. One end of clamping spring is fixed on support and the other end is connected to clamping end of clamping rod so as to provide to clamping rod an elastic force for clamping banknotes. 1. A banknote stacking and tidying module comprising a banknote tidying sub-module , a banknote stacking sub-module , and a banknote pressing and conveying sub-module , wherein the banknote pressing and conveying sub-module comprises:a pressing mechanism comprising a receiving plate, a bracket fixed on the receiving plate, a cam, a pressing rod and a pressing spring, wherein the cam is rotatably mounted on the bracket by means of a first rotating shaft, the pressing rod comprises a pressing end, a driving end and an articulating portion between the pressing end and the driving end, the articulating portion of the pressing rod is articulated on the bracket by means of a second rotating shaft, the cam is cooperated with the driving end of the pressing rod to drive the pressing rod to rotate about the second rotating shaft between a release position and a pressing position, one end of the pressing spring is fixed on the bracket, and the other end of the pressing spring is connected to the pressing end of the pressing rod for applying an elastic force to the pressing rod to press banknotes tightly;a pressing mechanism vertical reciprocating movement unit comprising ...

IMAGE PROCESSING DEVICE, IMAGE PROCESSING METHOD, PROGRAM, AND IMAGING DEVICE

A signal processing unit performs preprocessing, demosaic processing and color reproduction processing on an image signal. A control unit detects an image area having undergone a characteristic change exceeding a predetermined change amount, by using an image signal before the reproduction processing and an image signal after the color reproduction processing. The control unit associates area information indicating the detection result of the image area having undergone a characteristic change exceeding a predetermined change amount with the image signal after the color reproduction processing, and records the area information on a recording medium, or outputs the area information to an external device. Thus, it becomes possible to detect an image area where a control change caused by color reproduction processing is unnatural. 1. An image processing device comprisinga color reproduction processing unit that performs color reproduction processing on an image signal, andan area detection unit that detects an image area having undergone a characteristic change exceeding a predetermined change amount, by using an image signal before the color reproduction processing and an image signal after the color reproduction processing.2. The image processing device according to claim 1 , whereinwhen a change amount of a dispersion of a pixel signal after the color reproduction processing with respect to a dispersion of the pixel signal before the color reproduction processing in a predetermined area based on a determination target pixel exceeds a threshold, the area detection unit determines that the determination target pixel is a pixel in the image area having undergone a characteristic change exceeding a predetermined change amount.3. The image processing device according to claim 2 , whereinthe area detection unit adjusts the threshold according to an attribute of an image based on the image signal before the color reproduction processing.4. The image processing device ...

Five-Membered-Fused-Six-Membered Aza-Aromatic Ring Compound, Preparation Method Thereof, Pharmaceutical Composition And Application Thereof

The invention relates to the field of medicinal chemistry, and to five-membered-fused-six-membered aza-aromatic ring compound, preparation method thereof, pharmaceutical composition and application thereof. In particular, the invention relates to a type of compounds capable of specifically enhancing ubiquitination degradation of Ras proteins, a method for the preparation thereof, a pharmaceutical composition comprising the same, and use of these compounds in the manufacture of a medicament for preventing or treating a disease associated with Ras activity in vivo, in particular in the manufacture of a medicament for preventing or treating tumor growth and metastasis. 13. A pharmaceutical composition comprising the compound according to any one of - or a stereoisomer thereof , a prodrug thereof , a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate thereof and and optionally a pharmaceutically acceptable excipient. The invention relates to the field of medicinal chemistry, and in particular to a type of compounds capable of specifically enhancing ubiquitination degradation of Ras proteins, a method for the preparation thereof, a pharmaceutical composition comprising the same, and use of these compounds in the manufacture of a medicament for preventing or treating a disease associated with Ras activity in vivo, in particular in the manufacture of a medicament for preventing or treating tumor growth and metastasis.Ras protein, as a molecular switch in cells, plays a key role in numerous physiological and biochemical regulation processes in cells, including gene expression, cell growth and differentiation, cell cycle, cytoskeleton and cell migration, membrane vesicle transport, transport between nucleus and cytoplasm and the like. Meanwhile, Ras proteins (including H-Ras, K-Ras and N-Ras) are also the most common protooncoproteins in humans, closely related to tumor growth and transformation activity. RAS gene mutations are found in 20%-30% ...

MACHINE LEARNING BASED RECOMMENDATION OF VEHICLE

A vehicle recommendation device and a method for machine learning based recommendation of vehicle is provided. The vehicle recommendation device receives vehicle log data from a plurality of sensors associated with each of a first set of vehicles. The first set of vehicles are classified based on a set of vehicle types. The vehicle recommendation device generates vehicle trip data, associated with a plurality of trips of each of the first set of vehicles, based on the received vehicle log data. The vehicle recommendation device further determines a set of features, associated with the plurality of trips or with information about the first set of vehicles, based on the generated vehicle trip data. The vehicle recommendation device further generates a machine learning model which is trained based on the determined set of features to output a first type of vehicle from the set of vehicle types. 1. A vehicle recommendation device , comprising: receive vehicle log data from a plurality of sensors associated with each of a first set of vehicles, wherein the first set of vehicles are classified based on a set of vehicle types;', 'generate vehicle trip data, associated with a plurality of trips of each of the first set of vehicles, based on the received vehicle log data;', 'determine a set of features, associated with the plurality of trips or with information about the first set of vehicles, based on the generated vehicle trip data; and', 'generate a machine learning model which is trained based on the determined set of features to output a first type of vehicle from the set of vehicle types., 'circuitry configured to2. The vehicle recommendation device according to claim 1 , wherein the set of vehicle types comprises one of: a full hybrid electric vehicle (FHEV) or a non-full hybrid electric vehicle (non-FHEV).3. The vehicle recommendation device according to claim 1 , wherein the circuitry is further configured to:receive a set of values associated with the set of ...

Intelligent sensing device and sensing system

An intelligent sensing device and a sensing system are disclosed. The sensing device comprises a sensor unit provided with a plurality of sensors, and a wireless communication module, a memory module and a processing module connected with a data platform, wherein the processing module is connected with the sensor unit, the wireless communication module and the memory module; the processing module acquires the motion condition of a user by means of a preset detection algorithm according to a detection result of the acceleration sensor; and the sensing device has multiple different modes corresponding to different preset detection algorithms, and the user selects the preset detection algorithm by setting the mode of the sensing device. The sensing device is extremely low in power consumption, good in stability and sensitivity and high in storage capacity, can be interconnected with the data platform, and allows various sensors to be accessed thereto.

STK19 INHIBITORS FOR TREATMENT OF CANCER

Provided herein are compositions and methods for the treatment and prevention of cancer, including melanoma. 8. The compound of claim 1 , wherein Ror Rare independently H; or a substituted or unsubstituted alkoxy.9. The compound of claim 1 , wherein Ris H or —OR claim 1 , where Ris substituted or unsubstituted alkyl; substituted or unsubstituted cyclyl; substituted or unsubstituted heterocyclyl; substituted or unsubstituted aryl; substituted or unsubstituted heteroaryl.10. The compound of claim 1 , wherein Ris H or —OR claim 1 , where Ris substituted or unsubstituted C-Calkyl.11. The compound of claim 1 , wherein Ris H or —OR claim 1 , where Ris methyl claim 1 , ethyl claim 1 , propyl claim 1 , isopropyl claim 1 , 1-mthylpropy claim 1 , 2-methylpropyl claim 1 , butyl claim 1 , t-butyl claim 1 , pentyl or hexyl.12. The compound of claim 1 , wherein Ris H or —OR claim 1 , where Ris substituted or unsubstituted alkyl; substituted or unsubstituted cyclyl; substituted or unsubstituted hetrocyclyl; substituted or unsubstituted aryl; or substituted or unsubstituted heteroaryl.13. The compound of claim 1 , wherein Ris H or —OR claim 1 , where Ris substituted or unsubstituted C-Calkyl.14. The compound of claim 1 , wherein Ris H or —OR claim 1 , where Ris methyl claim 1 , ethyl claim 1 , propyl claim 1 , isopropyl claim 1 , 1-mthylpropy claim 1 , 2-methylpropyl claim 1 , butyl claim 1 , t-butyl claim 1 , pentyl or hexyl.15. The compound of claim 1 , wherein Rand Rare H or —OCH.16. The compound claim 1 , wherein Ror Rare each independently hydrogen claim 1 , alkyl claim 1 , halogen claim 1 , nitro claim 1 , cyano claim 1 , hydroxyl claim 1 , alkoxy claim 1 , carboxy claim 1 , amino claim 1 , alkylamino or dialkylamino.17. The compound of claim 1 , wherein Rand Rare hydrogen claim 1 , and Rand Rare H or —OCH.18. The compound of claim 1 , in combination with a pharmaceutically acceptable carrier or excipient.19. A method of treating cancer claim 1 , the method comprising ...

ROTOR DEVICE, TURBINE ROTOR DEVICE, AND GAS TURBINE AND TURBINE ENGINE HAVING SAME

Disclosed is a turbine rotor device for a gas turbine, the turbine rotor device comprising a turbine rotor body, and a pre-stressed fiber-wound layer, wherein the pre-stressed fiber-wound layer is wound on the periphery of the turbine rotor body to exert a predetermined pre-loading force on the turbine rotor body. Additionally, a rotor, and a gas turbine and a turbine engine having the turbine rotor device are also provided. 1. A turbine rotor device , comprising:a turbine rotor body; anda prestressed fiber-winding layer disposed on a periphery of the turbine rotor body for exerting a predetermined pre-loading force on the turbine rotor body, the prestressed fiber-winding layer comprises:a receiving trough disposed on the periphery of the turbine rotor body and defining a receiving groove extended in a circumferential direction of the receiving trough; andprestressed fibers wound within the receiving groove under a predetermined tensile stress.2. The turbine rotor device of claim 1 , wherein a coefficient of thermal expansion of the prestressed fiber-winding layer is less than or equal to that of the turbine rotor body.3. (canceled)4. The turbine rotor device of claim 1 , wherein a coefficient of thermal expansion of the prestressed fibers is less than or equal to that of the turbine rotor body.5. The turbine rotor device of claim 1 , wherein the turbine rotor body comprises:a rotor disc;a blade disposed on a periphery of the rotor disc; anda shroud disposed on a periphery of the blade, wherein the prestressed fiber winding layer is disposed on a periphery of the shroud.6. The turbine rotor device of claim 1 , wherein the tensile stress ranges from 0 to 10.0 GPa claim 1 , and a thickness of the prestressed fibers in a radial direction of the turbine rotor body ranges from 0.5 mm to 100 mm.7. The turbine rotor device of claim 5 , wherein the receiving trough and the shroud are formed separately; orthe receiving trough and the shroud are formed integrally.8. The ...

Method of semi-solid indirect squeeze casting for magnesium-based composite material

The present invention relates to a method of semi-solid indirect squeeze casting for Mg-based composite material, which aims at improving the mechanical property of the cast by adding magnesium zinc yttrium quasicrystal of high hardness, high elastic modulus and excellent matrix binding property acting as the reinforcement into the magnesium alloy matrix and manufacturing the cast through smelting using a vacuum atmosphere smelting furnace, agitating with ultrasonic wave assisted vibration in the rotating impeller jet agitation furnace and indirect squeeze casting against the problem of poor wettability, easy agglomeration, inhomogeneous distribution between the reinforcement particles and the matrix materials and poor properties of the manufactured cast. The manufacturing method of the present invention has advanced technologies and detailed and accurate data. The cast has excellent microstructure compactness, no shrinkage cavities and shrinkage defects and the primary phase in the metallographic structure consists of spherical and near-spherical crystalline grains, wherein dendritic crystalline grains almost disappear and the size of the crystalline grain is obviously refined. The tensile strength of the Mg-based composite material cast reaches to 225 Mpa, the elongation rate thereof reaches to 6.5% and the hardness thereof reaches to 86 HV. So the manufacturing method of the present invention is an advanced semi-solid indirect squeeze casting method for the Mg-based composite material.

BREAST PUMP

A breast pump comprising: a container comprising a deformable body and a lid, the container further comprising an inlet and a vent, wherein the vent is provided with a vent valve which is configured to allow air flow out of the container through the vent but not into the container through the vent; a nipple shield for receiving milk expressed from a user's breast; and a flexible conduit fluidly connecting the nipple shield and the inlet of the deformable container, wherein, in use, milk expressed from the breast flows from the nipple shield through the conduit to the container. 1. A breast pump comprising:a container including a deformable body and a lid, the container further including an inlet and a vent, wherein the vent is provided with a vent valve which is configured to allow air flow out of the container through the vent but not into the container through the vent;a nipple shield for receiving milk expressed from a user's breast; anda flexible conduit fluidly connecting the nipple shield and the inlet of the deformable container,wherein, in use, milk expressed from the breast flows from the nipple shield through the conduit to the container.2. The breast pump of claim 1 , wherein the flexible conduit is at least 500 mm long.3. The breast pump of claim 1 , wherein the flexible conduit includes a silicone tube.4. The breast pump of claim 1 , wherein the flexible conduit has an outside diameter of no more than 6 mm.5. The breast pump of claim 1 , wherein the conduit connecting portion is configured to direct the conduit away from the nipple shield in a direction such that claim 1 , in use claim 1 , at least an end portion of the conduit connected to the conduit connecting portion lies substantially alongside the user's body in use.6. The breast pump of claim 1 , wherein in use claim 1 , the nipple shield protrudes from a surface of the user's breast by a distance of 35 mm or less.7. The breast pump of claim 1 , wherein the nipple shield is resiliently deformable ...

IMAGE PROCESSING APPARATUS, METHOD THEREOF AND PROGRAM THEREFOR

An image processing apparatus includes a direction detection unit configured to detect a direction of a picture pattern of each picture in an input image having a predetermined color pixel array; a moire detection unit configured to detect a moire level by periodicity of a pixel value of each pixel in the input image depending on the direction as a moire index value; and a moire suppression unit configured to suppress the moire level in the input image based on the moire index value detected by the moire detection unit. A method thereof and a program therefor are also provided. 1. An image processing apparatus , comprising:a direction detection unit configured to detect a direction of a picture pattern of each picture in an input image having a predetermined color pixel array;a moire detection unit configured to detect a moire level by periodicity of a pixel value of each pixel in the input image depending on the direction as a moire index value; anda moire suppression unit configured to suppress the moire level in the input image based on the moire index value detected by the moire detection unit.2. The image processing apparatus according to claim 1 , whereinthe direction detection unit detects a direction of the picture pattern as a directional correlation value to a horizontal direction and a vertical direction, a horizontal moire detection unit configured to detect a horizontal moire index value that is a moire index value in a horizontal direction;', 'a vertical moire detection unit configured to detect a vertical moire index value that is a moire index value in a vertical direction; and', 'a mixed processing unit configured to mix the horizontal moire index value and the vertical moire index value depending on the directional correlation value to generate the moire index value, and, 'the moire detection unit includes'}outputs the moire index value generated by the mixed processing unit as a detection result.3. The image processing apparatus according to claim ...

SURVIVIN-TARGETING ANTI-TUMOR AGENTS AND USES THEREOF

Methods for treating various cancers by administering one or more compounds that target the dimeric protein survivin are disclosed. Pharmaceutical compositions containing such compounds are also disclosed, along with general methods of identifying anti-cancer compounds that target oncogenic dimeric proteins. Exemplary compounds that can be used in the disclosed methods of treatment and pharmaceutical compositions have the chemical structure: 126.-. (canceled)28. The method of where the composition is administered to the subject by a route selected from the group consisting of orally claim 27 , topically claim 27 , nasally claim 27 , parenterally claim 27 , paracancerally claim 27 , transmucosally claim 27 , transdermally claim 27 , intramuscularly claim 27 , intravenously claim 27 , intradermally claim 27 , subcutaneously claim 27 , intraperitoneally claim 27 , intraventricularly claim 27 , intracranially claim 27 , intratumorally claim 27 , or pulmonary delivery.29. The method of where the cancer treated is selected from the group consisting of breast cancer claim 27 , colon cancer claim 27 , lung cancer claim 27 , pancreatic cancer claim 27 , prostate cancer claim 27 , ovarian cancer claim 27 , and leukemia.30. The method of where the cancer treated is prostate cancer.33. The survivin-targeting compound of where the compound is for use in treating cancer that is selected from the group consisting of breast cancer claim 32 , colon cancer claim 32 , lung cancer claim 32 , pancreatic cancer claim 32 , prostate cancer claim 32 , ovarian cancer claim 32 , and leukemia.34. The survivin-targeting compound of where the compound is for use in treating prostate cancer.35. The survivin-targeting compound of where the compound is administered to the subject by a route selected from the group consisting of orally claim 32 , topically claim 32 , nasally claim 32 , parenterally claim 32 , paracancerally claim 32 , transmucosally claim 32 , transdermally claim 32 , ...

Method for ironmaking by smelting reduction in stir-generated vortex

A method for ironmaking by smelting reduction in a stir-generated vortex includes: (1) placing a pig iron in an induction furnace, and then heating the pig iron to a molten state to form a molten iron, and maintaining the molten iron to be greater than or equal to 1450° C.; (2) stirring a center of the molten iron to form a vortex with a height-to-diameter ratio of 0.5-2.5, and continuously performing stirring; (3) mixing and grinding on an iron-containing mineral, a reducing agent and a slag-forming agent in a mass ratio of 1:(0.1-0.15):(0.25-0.4) to obtain a powder mixture, spraying and blowing the powder mixture to a center of the vortex, performing a reduction reaction, and stopping the stirring after the molten iron and molten slags are obtained, wherein a waste gas is produced; and (4) discharging the molten iron and the molten slags respectively, and exhausting a treated waste gas.

HYDROXYALKYLAMINE- and HYDROXYCYCLOALKYLAMINE-SUBSTITUTED DIAMINE-ARYLSULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS

Disclosed are compounds of Formula A, or a salt thereof: 2) A compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein Ris —Cl or —Br.11) A compound of any of to claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein X is ═N—.12) A compound of any of to claim 1 , or or a pharmaceutically acceptable salt thereof claim 1 , wherein X is ═CH— claim 1 , ═C(CH)— claim 1 , or ═CF—.13) A compound claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , which is:4-[(4-{[(2S)-3-amino-2-hydroxypropyl]amino}butyl)amino]-5-chloro-2-fluoro-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide;4-[(4-{[3-amino-2-hydroxypropyl]amino}butyl)amino]-5-chloro-2-fluoro-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide;4-({4-[3-(aminomethyl)-3-hydroxyazetidin-1-yl]butyl}amino)-5-chloro-2-fluoro-N-(5-fluoro-1,3-thiazol-2-yl)benzenesulfonamide;4-({4-[3-(aminomethyl)-3-hydroxyazetidin-1-yl]butyl}amino)-5-chloro-2-fluoro-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide;2-fluoro-N-(5-fluoro-1,3-thiazol-2-yl)-4-[(4-{[(3-hydroxyazetidin-3-yl)methyl]amino}butyl)amino]-5-methylbenzenesulfonamide;5-bromo-2-fluoro-4-[(4-{[(3-hydroxyazetidin-3-yl)methyl]amino}butyl)amino]-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide;4-[(4-{[(2R)-3-amino-2-hydroxypropyl]-amino}butyl)amino]-5-chloro-2-fluoro-N-1,2,4-thiadiazol-5-yl-benzenesulfonamide;4-[(4-{[(2S)-3-amino-2-hydroxypropyl]-amino}butyl)amino]-5-bromo-2-fluoro-N-1,2,4-thiadiazol-5-yl-benzenesulfonamide;4-[(4-{[(2R)-3-amino-2-hydroxypropyl]-amino}-butyl)amino]-5-bromo-2-fluoro-N-1,2,4-thiadiazol-5-yl-benzenesulfonamide;4-[(4-{[3-amino-2-hydroxypropyl]-amino}-butyl)amino]-5-bromo-2-fluoro-N-1,2,4-thiadiazol-5-yl-benzenesulfonamide;5-chloro-2-fluoro-4-[(4-{[(3-hydroxyazetidin-3-yl)methyl]amino}butyl)amino]-N-(4-methyl-1,3-thiazol-2-yl)-benzenesulfonamide;5-chloro-2-fluoro-4-[(4-{[(3-hydroxyazetidin-3-yl)methyl]amino}butyl)amino]-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide;5-chloro-2-fluoro-4-[(4-{[(3R,4R)-4-hydroxypyrrolidin-3-yl]amino ...

ELECTRODE CAP GRINDING AND CHANGING ALL-IN-ONE (AIO) MACHINE

An electrode cap grinding and changing machine is provided. The machine includes a frame, a drive motor having an output end and a balanced floating unit, wherein the balanced floating unit is arranged on the frame, and the drive motor is arranged on the balanced floating unit, the output end of the drive motor penetrates through the balanced floating unit and then is connected with a working table having two sides, the two sides of the working table having a cap dismounting unit and a cap grinding unit drivably interconnected with the output end of the drive motor, and electrode cap storage units arranged at an outermost end of the two sides of the working table or on the frame. 1. An electrode cap grinding and changing machine , comprising:a frame,a drive motor having an output end and a balanced floating unit, wherein the balanced floating unit is arranged on the frame, and the drive motor is arranged on the balanced floating unit, the output end of the drive motor penetrates through the balanced floating unit and then is connected with a working table having two sides, the two sides of the working table having a cap dismounting unit and a cap grinding unit drivably interconnected with the output end of the drive motor, andelectrode cap storage units arranged at an outermost end of the two sides of the working table or on the frame.2. The electrode cap grinding and changing machine according to claim 1 , wherein the output end of the drive motor includes an output shaft gear; the cap dismounting unit comprises:a cap dismounting straight gear,a worm shaft coaxially connected with the cap dismounting straight gear,a cap dismounting worm wheel engaged with the worm shaft, andan electrode cap gripper connected in a center of the cap dismounting worm through a rotating shaft; wherein the electrode cap gripper including a pre-tightening spring; the cap grinding unit comprising a grinding straight gear, a grinding bevel pinion coaxially provided with the grinding ...

USE OF gTso thal IN MANUFACTURING MEDICAMENT FOR PROMOTION OF MS-275 TO CROSS BLOOD-BRAIN BARRIER

The present invention relates to use of gTso thal in manufacturing a medicament for the promotion of MS-275 to cross the blood-brain barrier (BBB), and belongs to the technical field of pharmaceutical preparation. Administration of the medicament manufactured by the use of the present invention in combination with MS-275 significantly increases MS-275 to cross the BBB into the brain tissue, and prominently promotes the accumulation of the medicament therein. 1. A medicament for the promotion of MS-275 to cross the blood-brain barrier (BBB) , comprising gTso thal and pharmaceutically acceptable excipients.2. The medicament according to claim 1 , wherein the pharmaceutical dosage form comprises injection claim 1 , powder injection claim 1 , granule claim 1 , or capsule.3. The medicament according to claim 1 , wherein the pharmaceutically acceptable excipients comprise: sodium carboxymethylcellulose (CMC-Na) in the injection; glucose claim 1 , lactose claim 1 , and/or mannitol in the powder injection; starch claim 1 , lactose claim 1 , magnesium stearate claim 1 , aerosil claim 1 , and/or polysorbate 80 in the capsule; starch claim 1 , lactose claim 1 , dextrin claim 1 , and/or hydroxypropyl methyl cellulose (HPMC) in the granule.4. A method for manufacturing a medicament for the promotion of MS-275 to cross the BBB by gTso thal claim 1 , comprising the following steps: mixing gTso thal with pharmaceutically acceptable excipient(s) to manufacture the medicament.5. A method for promoting MS-275 to cross the BBB by the medicament according to claim 1 , wherein the medicament is administered in advance claim 1 , followed by MS-275; alternatively claim 1 , the medicament and MS-275 are administered concomitantly.6. The method according to claim 1 , wherein gTso thal and MS-275 are mixed in a mass ratio of (1-10):(0.1-200 claim 1 ,000) in the medicament.7. The method according to claim 1 , wherein gTso thal and MS-275 are mixed in a mass ratio of (1-10):(10-5 claim 1 ,000) ...

ADDITIVE MANUFACTURING EQUIPMENT UTILIZING COMBINED ELECTRON BEAM SELECTIVE MELTING AND ELECTRON BEAM BUTTING

An additive manufacturing apparatus utilizing combined electron beam selective melting and electron beam cutting. One electron beam emitting, focusing, and scanning device () is capable of emitting electron beams () in three modes of heating, selective melting, and electron beam cutting. The electron beam in the heating mode is emitted to scan and preheat a powder bed (). The electron beam () in the selective melting mode is emitted to scan and melt powder () in a section outline to form a section layer of a component. The electron beam () in the electron beam cutting mode is emitted to perform one or more cutting scans on inner and outer outlines () of a section of the component to obtain accurate and smooth inner and outer outlines of the section. The heating, melting deposition, and outline cutting processes are repeated to obtain a required three-dimensional physical component. 1. An additive manufacturing apparatus utilizing combined electron beam selective melting and electron beam cutting , comprising ,a vacuum forming chamber;a workbench, a forming area of the workbench being provided at least in the vacuum forming chamber;a powder supply device configured to spread powder on the forming area;at least one electron beam emitting, focusing and scanning device, a scanning range of the electron beam emitting, focusing and scanning device covering at least a part of the forming area; anda controller configured to control each of the electron beam emitting, focusing and scanning device to operate to emit an electron beam in three modes of heating, selective melting and electron beam cutting;wherein the powder supply device spreads the powder onto the forming area to form a powder bed with a certain thickness;the electron beam emitting, focusing and scanning device emits the electron beam in the heating mode, and the electron beam scans and preheats the powder bed so as to heat and slight-sinter the powder;the electron beam emitting, focusing and scanning device ...

METHOD FOR PREPARING TITANIUM ALLOYS BASED ON ALUMINOTHERMIC SELF-PROPAGATING GRADIENT REDUCTION AND SLAG-WASHING REFINING

The invention relates to a method for preparing titanium alloys based on aluminothermic self-propagating gradient reduction and slag-washing refining, and belongs to the technical field of titanium-aluminum alloys. The method comprises the following steps of pre-treating raw materials, weighing the raw materials in the mass ratio of rutile or high-titanium slags or titanium dioxide to aluminum powder to VOpowder to CaO to KClObeing 1.0:(0.60-0.24):(0.042-0.048):(0.12-0.26):(0.22-0.30), performing an aluminothermic self-propagating reaction in a gradient feeding manner to obtain high-temperature melt, performing a gradient reduction melting, performing heat insulation and separating the melt after the feeding is completed, then adding CaF—CaO—TiO—VObased refining slags into the high-temperature melt, performing slag washing refining, and finally removing slags to obtain titanium alloys. This method has the advantages including short flow, low energy consumption, easy operation, easy control on Al and V contained in alloys, and so on. 1. A method for preparing titanium alloys based on aluminothermic self-propagating gradient reduction and slag-washing refining , comprising the following steps:Step 1: material pre-treatment{'sub': 2', '5', '3, 'pre-treating aluminothermic reduction reaction materials separately to obtain pre-treated aluminothermic reduction reaction materials, wherein the aluminothermic reduction reaction materials include titanium-containing material, aluminum powder, VOpowder, CaO and KClO, the titanium-containing material is at least one selected from the group consisting of rutile, high-titanium slags and titanium dioxide;'}{'sub': 2', '5', '3, 'weighing the pre-treated aluminothermic reduction reaction materials with a proportional ratio, wherein the proportional ratio is a mass ratio of titanium-containing material:aluminum powder:VOpowder:CaO:KClObeing 1.0:(0.60-0.24):(0.042-0.048):(0.12-0.26):(0.22-0.30);'}{'sub': 2', '5', '3, 'wherein the ...

SYSTEM AND METHOD FOR PROVIDING POINT OF INTEREST RELATED NOTIFICATIONS

A system and method for providing point of interest related notifications within a vehicle that include receiving sensor data associated with an opening of at least one vehicle window of the vehicle. The system and method also include storing a first geo-location of the vehicle based on the sensor data and determining if a subsequent geo-location of the vehicle is within a predetermined vicinity of at least one point of interest. The system and method further include providing at least one point of interest related notification associated with the at least one point of interest if it is determined that the subsequent geo-location of the vehicle is within the predetermined vicinity of the at least one point of interest. 1. A computer-implemented method for providing point of interest related notifications within a vehicle , comprising:receiving sensor data associated with an opening of at least one vehicle window of the vehicle;storing a first geo-location of the vehicle based on the sensor data, wherein at least one point of interest is determined to be located within a predetermined distance of the first geo-location of the vehicle;determining if a subsequent geo-location of the vehicle is within a predetermined vicinity of the at least one point of interest; andproviding at least one point of interest related notification associated with the at least one point of interest if it is determined that the subsequent geo-location of the vehicle is within the predetermined vicinity of the at least one point of interest.2. The computer-implemented method of claim 1 , wherein storing the first geo-location of the vehicle includes determining if the first geo-location of the vehicle is different from a last stored geo-location of the vehicle.3. The computer-implemented method of claim 2 , wherein storing the first geo-location of the vehicle includes communicating the first geo-location of the vehicle from the vehicle to an external server claim 2 , wherein a vehicle trip ...

SURVIVIN-TARGETING ANTI-TUMOR AGENTS AND USES THEREOF

Methods for treating various cancers by administering one or more compounds that target the dimeric protein survivin are disclosed. Pharmaceutical compositions containing such compounds are also disclosed, along with general methods of identifying anti-cancer compounds that target oncogenic dimeric proteins. Exemplary compounds that can be used in the disclosed methods of treatment and pharmaceutical compositions have the chemical structures disclosed in the specification. 2. The method of claim 1 , wherein the composition is administered to the subject orally claim 1 , topically claim 1 , nasally claim 1 , parenterally claim 1 , paracancerally claim 1 , transmucosally claim 1 , transdermally claim 1 , intramuscularly claim 1 , intravenously claim 1 , intradermally claim 1 , subcutaneously claim 1 , intraperitoneally claim 1 , intraventricularly claim 1 , intracranially claim 1 , intratumorally claim 1 , or by pulmonary delivery.3. The method of claim 1 , wherein the subject in need thereof is selected from the group consisting subjects with at least one of the following diseases: breast cancer claim 1 , colon cancer claim 1 , lung cancer claim 1 , pancreatic cancer claim 1 , prostate cancer claim 1 , ovarian cancer claim 1 , and leukemia.4. The method of claim 3 , wherein the subject in need thereof has prostate cancer.5. The method of claim 1 , further comprising: administering to a subject in need thereof a pharmaceutically acceptable carrier.9. The survivin-targeting compound of claim 8 , wherein the compound is for use in treating cancer that is selected from the group consisting of breast cancer claim 8 , colon cancer claim 8 , lung cancer claim 8 , pancreatic cancer claim 8 , prostate cancer claim 8 , ovarian cancer claim 8 , and leukemia.10. The survivin-targeting compound of claim 8 , wherein the compound is for use in treating prostate cancer.11. The survivin-targeting compound of claim 10 , wherein the compound is to be administered to the subject orally ...

ETORICOXIB SOLVATES AND PREPARATION METHOD THEREOF

The disclosure relates to etoricoxib solvates and a preparation method thereof. A solvent is a hydrogen bond donor solvent with a polarity value π* ranging from 60 to 100 or a hydrogen bond acceptor solvent with a polarity value π* ranging from 92 to 100. Solvents with a polarity value π* within the above range all can form corresponding etoricoxib solvates with etoricoxib. The etoricoxib solvate can be prepared by cooling crystallization or suspension crystallization. A 1,2-propanediol solvate of etoricoxib and a dimethyl sulfoxide (DMSO) solvate of etoricoxib provided in the present disclosure have high thermal stability, unique crystal form, large size, concentrated distribution, and prominent flowability and is safe, pharmaceutically acceptable, and not easy to agglomerate. Compared with etoricoxib, the etoricoxib solvates exhibit significantly improved solubility. Moreover, preparation of the solvates requires low consumption in time, energy, and solvent, and has high efficiency, with a molar yield higher than 90%. 1. Etoricoxib solvates , wherein , a solvent is a hydrogen bond donor solvent with a polarity value π* ranging from 60 to 100 or a hydrogen bond acceptor solvent with a polarity value π* ranging from 92 to 100.2. The etoricoxib solvates according to claim 1 , wherein claim 1 , the hydrogen bond donor solvent with a polarity value π* ranging from 60 to 100 comprises: methanol with a polarity value π*=60 claim 1 , 1 claim 1 ,2-propanediol with a polarity value π*=85 claim 1 , ethylene glycol (EG) with a polarity value π*=92 claim 1 , and formamide with a polarity value π*=97; and the hydrogen bond acceptor solvent with a polarity value π* ranging from 92 to 100 comprises: N-methylpyrrolidone (NMP) with a polarity value π*=92 and dimethyl sulfoxide (DMSO) with a polarity value π*=100.3. The etoricoxib solvates according to claim 1 , comprising a methanol solvate of etoricoxib claim 1 , a 1 claim 1 ,2-propanediol solvate of etoricoxib claim 1 , an EG ...

ANTI-B7H3 ANTIBODY-EXATECAN ANALOG CONJUGATE AND MEDICINAL USE THEREOF

Disclosed by the present invention are an anti-B7H3 antibody-exatecan analog conjugate, a preparation method therefor and an anti-tumor medicinal use thereof. 2. The ligand-drug conjugate of formula (Pc-L-Y-Dr) or the pharmaceutically acceptable salt or solvate thereof according to claim 1 , wherein the anti-B7H3 antibody or the antigen-binding fragment thereof comprises:the heavy chains HCDR1, HCDR2 and HCDR3 represented by the amino acid sequences of SEQ ID NO: 8, 9 and 10 respectively, or HCDR variants having 3, 2 or 1 amino acid difference(s) from HCDR1, HCDR2 and HCDR3 represented by SEQ ID NO: 8, 9 and 10 respectively; andthe light chains LCDR1, LCDR2 and LCDR3 represented by the amino acid sequences of SEQ ID NO: 11, 12 and 13 respectively, or LCDR variants having 3, 2 or 1 amino acid difference(s) from LCDR1, LCDR2 and LCDR3 represented by SEQ ID NO: 11, 12 and 13 respectively.3. (canceled)4. The ligand-drug conjugate of formula (Pc-L-Y-Dr) or the pharmaceutically acceptable salt or solvate thereof according to claim 1 , wherein the anti-B7H3 antibody or the antigen-binding fragment thereof comprises a heavy chain variable region and/or a light chain variable region:wherein the amino acid sequence of the heavy chain variable region is represented by SEQ ID NO: 6 or has at least 95% sequence identity with SEQ ID NO: 6, the amino acid sequence of the light chain variable region is represented by SEQ ID NO: 7 or has at least 95% sequence identity with SEQ ID NO: 7.5. (canceled)6. The ligand-drug conjugate of formula (Pc-L-Y-Dr) or the pharmaceutically acceptable salt or solvate thereof according to claim 1 , wherein Pc is a full-length antibody claim 1 , wherein the full-length antibody is selected from the group consisting of:the h1702 antibody consisting of the heavy chain sequence represented by SEQ ID NO: 14 and the light chain sequence represented by SEQ ID NO: 15, andthe h1702DS antibody consisting of the heavy chain sequence represented by SEQ ID NO: 14 ...

DETERMINING DROPPED CALL RATES IN IP MULTIMEDIA NETWORKS

Systems and methods are described herein for determining dropped call rates (DCR) for various communications networks, such as IP Multimedia Networks (IMS), which include Voice over LTE (VoLTE) networks. For example, the systems and methods utilize data (e.g. abnormal cause codes) generated by layers of the IMS networks, such as a Session Initiation Protocol (SIP) layer of the IMS network, when determining dropped call rates for IMS networks. 1. A method for determining a dropped call rate for an IP Multimedia System (IMS) network , the method comprising: 'wherein the call detail records include data from a Session Initiation Protocol (SIP) layer of the IMS network;', 'accessing call detail records (CDR) generated by a Telephone Application Server (TAS) of the IMS network,'}selecting call detail records that include one or more cause codes associated with abnormal communication sessions between mobile devices over the IMS network;applying a set of filtering criteria to the selected call detail records to identify a group of call detail records associated with a dropped call within the IMS network; anddetermining a dropped call rate (DCR) for the IMS network that is based on the identified group of call detail records associated with a dropped call within the network.2. The method of claim 1 , further comprising:accessing a baseline dropped call rate provided by a radio access network (RAN) component of the IMS network; andadjusting the baseline dropped call rate with the determined dropped call rate for the IMS network to determine a modified dropped call rate for the IMS network that is based on information obtained from the SIP layer of the IMS network and information obtained from a radio access layer of the IMS network.3. The method of claim 1 , wherein determining a dropped call rate (DCR) for the IMS network includes determining an overall dropped call rate for the IMS network that is based on a single radio voice call continuity (SRVCC) dropped call rate for ...

DETERMINING NETWORK PERFORMANCE METRICS USING CUSTOMER-SPECIFIC INFORMATION

Systems and methods are described herein for analyzing the performance of a communications network (e.g., a mobile telecommunications network) using customer-centric and/or subscriber-centric data and information. In some embodiments, the systems and method may determine key performance indicators for a communications network by accessing call detail records from multiple communications network sources, generating a database of one or more customer stats table (CSTs) based on the accessed call records, wherein the CSTs include records for each individual customers of the communications network, and determining one or more key performance indicators (KPIs) for the overall network based on the records stored by the one or more customer stats tables. 1. A method for modifying performance of a communications network , the method comprising: 'wherein the accessed call records include individual records for each occurrence of a call, message, and data session within the communications network;', 'accessing call records from multiple sources of the communications network,'} customer usage data for customers of the communications network,', 'customer profile data for the customers of the communications network, and', 'customer top cell usage data for the customers of the communications network;, 'wherein the one or more customer stats tables store customer-centric data over a certain period of time, the customer-centric data including, 'generating a database of one or more customer stats table (CSTs) based on the accessed call records,'}determining one or more key performance indicators (KPIs) based on data contained in the one or more customer stats tables;identifying one or more cells of the communications network that are performing sub-optimally based on the determined one or more key performance indicators; andperforming an action with respect to the identified one or more cells of the communications network.2. The method of claim 1 , wherein accessing call records ...

AUTOMATED INTERVENTION TO MODIFY DRIVING BEHAVIORS

A computer-implemented method includes receiving a data stream, the data stream including one or more driving factors. The computer-implemented method further includes comparing the one or more driving factors to one or more known driving factors to identify a driving scenario. The computer-implemented method further includes monitoring the driving scenario for a risk. Monitoring the driving scenario for a risk further includes detecting the risk. The computer-implemented method further includes generating an intervention, wherein the intervention is generated based on detecting the risk for the driving scenario. A corresponding computer system and computer program product are also disclosed. 1. A computer-implemented method comprising:detecting a risk associated with a first instance of a driving scenario;generating a first intervention, wherein the first intervention is based on the risk associated with the first instance of the driving scenario;determining that the first intervention does not minimize the risk; andmodifying the first intervention to yield a second intervention, wherein the second intervention is different than the first intervention.2. The computer-implemented method of claim 1 , wherein the driving scenario is identified based claim 1 , at least in part claim 1 , on:identifying one or more driving factors; andcomparing the one or more driving factors to one or more known driving factors.3. The computer-implemented method of claim 1 , wherein detecting the risk is based claim 1 , at least in part claim 1 , on:one or more rules associated with the driving scenario.4. The computer-implemented method of claim 1 , further comprising:detecting the risk associated with a second instance of the driving scenario; andexecuting the second intervention.5. The computer-implemented method of claim 4 , further comprising:determining that executing the second intervention does minimize the risk; andterminating the second intervention after the risk is minimized ...

BREAST PUMP AND FEEDING KIT

A breast pump () comprises a cup member () and a container (). The cup member () has a breast engaging portion () configured to seal to a breast. The container () is configured to be removably and sealingly connected to the cup member (). The container () is configured to be deformed by a user and released to create suction on the breast to pump breast milk into the container (). A breast pump () and feeding kit for pumping, storing and feeding breast milk is also disclosed. The kit comprises a deformable container () which may be attached to one of a cup member (), a teat (), or a lid (). The teat () is configured to feed breast milk from the container () to a baby. The lid () is configured to secure the breast milk in the container for storage. 144-. (canceled)45. A breast pump and feeding kit for the pumping and feeding of breast milk , the kit comprising:a cup member having a breast engaging portion configured to seal to a breast;a container; anda teat,wherein the cup member and the container are configured to be removably and sealingly connected together and the container is configured to be deformed by a user and released to create suction on the breast to pump breast milk from the breast into the container; andwherein the teat and the container are configured to be removably and sealingly connected together for feeding breast milk from the container to a baby.46. The breast pump and feeding kit of claim 45 , further comprising a ring member configured to connect the cup member to the container claim 45 , the ring member also being configured to connect the teat to the container in place of the cup member.47. The breast pump and feeding kit of claim 45 , wherein the ring member is substantially rigid.48. The breast pump and feeding kit of claim 46 , wherein the container comprises a rim comprising a screw thread to connect to a complementary screw thread on the ring member.49. The breast pump and feeding kit of claim 46 , wherein the cup member and the ring ...

Serum/plasma LncRNA marker composition associated with auxiliary diagnosis of intrahepatic cholestasis of pregnancy and application thereof

A serum/plasma LncRNA marker composition associated with auxiliary diagnosis of intrahepatic cholestasis of pregnancy and application thereof. The marker is selected from any one of ENST00000449605.1, ASO3480 and ENST00000505175.1. The serum/plasma LncRNA screening and auxiliary diagnosis kit is a LncRNAs diagnostic kit developed based on the specific serum/plasma LncRNA of ICP cases and healthy controls. 1. A diagnostic kit for detecting an intrahepatic cholestasis of pregnancy in a sample of a subject comprising a reverse transcriptase , a DNA polymerase , dNTPs , a buffer and at least one pair of primers capable of amplifying one fragment of DNA from cDNA of an ENST00000449605.1 , ASO3480 or ENST00000505175.1.2. The diagnostic kit according to claim 1 , wherein the ENST00000449605.1 claim 1 , ASO3480 and ENST00000505175.1 are RNAs whose cDNAs having DNA sequences shown as SEQ ID NO: 7 claim 1 , SEQ ID NO: 8 and SEQ ID NO: 9 claim 1 , respectively.3. The diagnostic kit according to claim 2 , wherein the pair of primers has the DNA sequences shown in SEQ ID No. 1 and SEQ ID No. 2 claim 2 , in SEQ ID No. 3 and SEQ ID No. 4 or in SEQ ID No. 5 and SEQ ID No. 6 which amplifies the fragment of DNA from the cDNA of the ENST00000449605.1 claim 2 , ASO3480 or ENST00000505175.1 claim 2 , respectively.4. The diagnostic kit according to claim 1 , wherein the buffer contains SYBR Green.5. The diagnostic kit according to claim 1 , wherein the kit is capable of using for real-time PCR.6. The diagnostic kit according to claim 1 , wherein the subject is a pregnancy woman claim 1 , the sample is a serum or plasma from the pregnancy woman.7. The diagnostic kit according to claim 1 , wherein the kit comprises an instruction for using the kit to evaluate the intrahepatic cholestasis of pregnancy in the subject.8. A method for detecting an intrahepatic cholestasis of pregnancy comprising a step for detecting a LncRNA (Long non-coding RNA) marker in a sample of a subject claim 1 , the ...

METHOD FOR PREPARING HIGH-MELTING-POINT METAL POWDER THROUGH MULTI-STAGE DEEP REDUCTION

The invention relates to a method for preparing high-melting-point metal powder through multi-stage deep reduction, and belongs to the technical field of preparation of powder. The method includes the following steps of mixing dried high-melting-point metal oxide powder with magnesium powder and performing a self-propagating reaction, placing an intermediate product into a closed reaction kettle, leaching the intermediate product with hydrochloric acid as a leaching solution so as to obtain a low-valence oxide MeO precursor of the low-valence high-melting-point metal; uniformly mixing the precursor with calcium powder, pressing the mixture, placing the pressed mixture into a vacuum reduction furnace, heating the vacuum reduction furnace to 700-1200° C., performing deep reduction for 1-6 h, leaching a deep reduction product with hydrochloric acid as a leaching solution and performing treatment, so as to obtain the high-melting-point metal powder. 1. A method for preparing a high-melting-point metal powder through a multi-stage deep reduction , comprising the following steps: [{'sub': 'x', 'drying a high-melting-point metal oxide powder to obtain a dried high-melting-point metal oxide powder, mixing the dried high-melting-point metal oxide powder with magnesium (Mg) powder to obtain mixed materials, adding the mixed materials into a self-propagating reaction furnace to perform the self-propagating reaction, and performing cooling to obtain an intermediate product in which a low-valence oxide MeO of a high-melting-point metal (Me) is dispersed in an MgO matrix,'}, {'sub': 'x', 'wherein the intermediate product in which the low-valence oxide MeO of the high-melting-point metal is dispersed in the MgO matrix is a mixture of low-valence high-melting-point metal oxides with a non-stoichiometric ratio,'}, 'x is 0.2-1,', 'the high-melting-point metal specifically comprises one or more of W, Mo, Ta, Nb, V, Zr, Hf and Re,', {'sub': 3', '3', '2', '5', '2', '5', '2', '5', '2', ' ...

Method for preparing reduced titanuim powder by multistage deep reduction

Provided is a method for preparing a reduced titanium powder by a multistage deep reduction, including the following steps of: uniformly mixing a dried titanium dioxide powder with a magnesium powder to obtain a mixture, adding the mixture in a self-propagating reaction furnace, triggering a self-propagating reaction, obtaining an intermediate product of which low-valence titanium oxides Ti x O are dispersed in an MgO matrix, leaching the intermediate product with a hydrochloric acid as a leaching solution, performing filtering, washing and vacuum drying to obtain a low-valence titanium oxide Ti x O precursor, uniformly mixing the low-valence titanium oxide Ti x O precursor with a calcium powder, performing a pressing to obtain semi-finished products, placing the semi-finished products in a vacuum reduction furnace for a second-time deep reduction, and leaching a deep reduction product with a hydrochloric acid as a leaching solution so as to obtain the reduced titanium powder.

SURVIVIN-TARGETING ANTI-TUMOR AGENTS AND USES THEREOF

Methods for treating various cancers by administering one or more compounds that target the dimeric protein survivin are disclosed. Pharmaceutical compositions containing such compounds are also disclosed, along with general methods of identifying anti-cancer compounds that target oncogenic dimeric proteins. Exemplary compounds that can be used in the disclosed methods of treatment and pharmaceutical compositions have the chemical structure. 4. The method of claim 1 , wherein the composition is administered to the subject orally claim 1 , topically claim 1 , nasally claim 1 , parenterally claim 1 , paracancerally claim 1 , transmucosally claim 1 , transdermally claim 1 , intramuscularly claim 1 , intravenously claim 1 , intradermally claim 1 , subcutaneously claim 1 , intraperitoneally claim 1 , intraventricularly claim 1 , intracranially claim 1 , intratumorally claim 1 , or by pulmonary delivery.5. The method of claim 1 , wherein the cancer that is treated is selected from the group consisting of breast cancer claim 1 , colon cancer claim 1 , lung cancer claim 1 , pancreatic cancer claim 1 , prostate cancer claim 1 , ovarian cancer claim 1 , and leukemia.6. The method of claim 5 , wherein the cancer that is treated is prostate cancer.13. The survivin-targeting compound of claim 10 , wherein the compound is for use in treating cancer that is selected from the group consisting of breast cancer claim 10 , colon cancer claim 10 , lung cancer claim 10 , pancreatic cancer claim 10 , prostate cancer claim 10 , ovarian cancer claim 10 , and leukemia.14. The survivin-targeting compound of claim 13 , wherein the compound is for use in treating prostate cancer.15. The survivin-targeting compound of claim 10 , wherein the compound is to be administered to the subject orally claim 10 , topically claim 10 , nasally claim 10 , parenterally claim 10 , paracancerally claim 10 , transmucosally claim 10 , transdermally claim 10 , intramuscularly claim 10 , intravenously claim 10 , ...

STEAM IRON WITH INDEPENDENT AIR SUCTION SYSTEM

The present disclosure provides a steam iron with an independent air suction system includes an ironing body. An air suction system is disposed on the ironing body. The air suction system includes an air suction structure, an electromotor, an impeller, a filter screen, an air outlet, an air inlet passage, a suction head, and a speed-control switch. The air suction structure is disposed on the ironing body. An inlet end of the air suction structure is connected to the air inlet passage via the filter screen.

Ride-hailing vehicle identification

The present disclosure generally relates to methods and systems for determining usage of a vehicle. A vehicle monitoring system may include a memory, at least one processor coupled to the memory, and a sensor system that generates vehicle trip data. The system may periodically determine a location of the vehicle during a trip while an ignition of the vehicle remains on. The system may determine that a duration of the trip is at least a threshold duration. The system may determine a direction of travel for segments between consecutive locations during the trip. The system may determine a ratio of a most common direction of travel for the trip to at least a second most common direction of travel for the trip. The system may determine that the vehicle has been used for commercial purposes in response to the ratio being less than a threshold ratio.

METHOD FOR THE PREPARATION OF A PROTEIN PEPTIDE, A PROTEIN PEPTIDE AND USE THEREOF

The present invention discloses a method for the preparation of a protein peptide, peptide powder prepared thereby, and use of the peptide powder in hypouricemic food products or health care products. The peptide powder is capable of inhibiting the activity of xanthine oxidase and effectively reducing uric acid. The method in an example of the present invention comprises: mincing the tuna, heating with steam or water to obtain a pretreated tuna, enzymolysing the pretreated tuna, deactivating the enzyme, centrifuging, removing impurities to obtain a supernatant, concentrating, and drying to obtain the peptide powder of interest. 1. A method for the preparation of a protein peptide , characterized in that comprising:(1) mincing tuna, heating after adding water or heating with water steam to obtain pretreated tuna;(2) enzymolysing the pretreated tuna, deactivating the enzyme, centrifuging to obtain a supernatant;(3) concentrating the supernatant and drying to obtain the peptide powder of interest, which is the protein peptide.2. The method according to claim 1 , characterized in that the step of heating after adding water or heating with steam comprises heating at 80 to 100° C. for 5 to 30 min with steam or water.3. The method according to claim 1 , characterized in that the steps of enzymolysis and deactivating the enzyme comprise: mixing the pretreated tuna with protease at a temperature of 50 to 60° C. for 3.0 to 9.0 h; deactivating the enzyme at a temperature of 90 to 100° C. for 10 to 30 min after completion of the reaction.4. The method according to claim 1 , characterized in that the protease used in enzymolysis is one or more of acid protease claim 1 , papain claim 1 , pepsin claim 1 , trypsin claim 1 , proteolytic enzyme claim 1 , neutrase claim 1 , flavourzyme and Alcalase claim 1 , and the protease is used in an amount of 0.2% to 3.2% by weight of the pretreated tuna.5. The method according to claim 1 , characterized in that further comprises removing ...

METHOD FOR THE PREPARATION OF SKIPJACK TUNA EXTRACT HAVING URIC ACID-LOWERING EFFECT AND THE USE THEREOF

The present invention discloses a method for the preparation of skipjack tuna extract having hypouricemic effect and the use thereof, which is simple in processing operations, low in production cost, and is free from pollution. The prepared skipjack tuna extract has a potent hypouricemic effect, and has a significant therapeutic effect on hyperuricemia, with no toxic and side effects. The method in an example of the present invention comprises: pretreating skipjack tuna to obtain a skipjack tuna slurry; enzymolysing the skipjack tuna slurry to obtain a crude enzymolysis liquid; removing fishy smell and bitter taste, removing impurities by activated charcoal, and filtering to obtain a refinded enzymolysis liquid; concentrating under vacuum and spray-drying to obtain the skipjack tuna extract. The present invention further discloses use of the skipjack tuna extract in health care products or food products. 1. A method for the preparation of skipjack tuna (bonito) extract having uric acid lowering effect , comprising:(1) removing the head and entrails of the skipjack tuna before mincing, adding 1 to 2 times of water by weight of the minced skipjack tuna, heating under stirring at 80 to 100° C. for 5 to 30 min, and then lowering the temperature to 50 to 60° C. to obtain a skipjack tuna slurry;(2) adding 0.2% to 3.2% of protease by weight of the minced skipjack tuna to the skipjack tuna slurry, carrying out hydrolyzation for 5 to 9 h while keeping the temperature at 50 to 55° C., then heating to 85 to 95° C. which is kept for 15 to 30 min to deactivate the enzyme, and centrifuging to obtain a supernatant, which is a crude enzymatic hydrolysate;(3) adding 0.5% to 1.0% of activated charcoal by weight of the crude enzymatic hydrolysate to the crude enzymatic hydrolysate, stirring for 0.5 to 1.0 hour at a temperature of 45 to 55° C., and then filtering through a 0.5 μm filter paper to obtain a refined enzymatic hydrolysate;(4) concentrating the refined enzymatic hydrolysate ...

Factor IXa Inhibitors

The present invention provides a compound of Formula (I) 8. A compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein Rand Rare H claim 1 , and Rand Rare CH.9. A compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein R claim 1 , Rand Rare H claim 1 , and Ris CH.10. A compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein R claim 1 , Rand Rare H claim 1 , and Ris CH.11. A compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein R claim 1 , Rand Rare H claim 1 , and Ris CH.12. A compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein Rand Rare CH claim 1 , and Rand Rare H.13. A compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein R claim 1 , Rand Rare H claim 1 , and Ris CHOH.14. A compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein R claim 1 , Rand Rare H claim 1 , and Ris CHCH.15. A compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , which is(2R)—N-(3-Amino-1,2-benzoxazol-6-yl)-2-hydroxy-2-[(2R)-4-[1-(2-methoxy-4-pyridyl)pyrazol-3-yl]-3-oxo-morpholin-2-yl]propanamide,(R)—N-(3-Aminoisoxazolo[4,5-b]pyridin-6-yl)-2-hydroxy-2-((R)-4-(1-(2-methoxypyridin-4-yl)-1H-pyrazol-3-yl)-3-oxomorpholin-2-yl)propanamide,(R)—N-(3-Aminobenzo[d]isoxazol-6-yl)-2-(R)-4-(1-(6-cyanopyridazin-4-yl)-5-methyl-1H-pyrazol-3-yl)-3-oxomorpholin-2-yl)-2-hydroxypropanamide,(R)—N-(3-Aminobenzo[d]isoxazol-6-yl)-2-(R)-4-(1-(6-ethoxypyridazin-4-yl)-1H-pyrazol-3-yl)-3-oxomorpholin-2-yl)-2-hydroxypropanamide,5-(3-((R)-2-((R)-1-((3-Aminobenzo[d]isoxazol-6-yl)amino)-2-hydroxy-1-oxopropan-2-yl)-3-oxomorpholino)-1H-pyrazol-1-yl)pyridazine-3-carboxamide,(2R)—N-(3-Aminobenzo[d]isoxazol-6-yl)-2-((2R)-4-(1-(6-((1-chloro-3-hydroxypropan-2-yl)oxy)pyridazin-4-yl)-1H-pyrazol-3-yl)-3-oxomorpholin-2-yl)-2-hydroxypropanamide,(R)—N-(3-Aminobenzo[d]isoxazol-6-yl)-2-((R)-4-(1-(1-( ...

PYRIMIDOPYRROLE COMPOUNDS, METHOD FOR PREPARING THE SAME, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME AND USES THEREOF

The present invention relates to a compound of formula I, a stereoisomer, a prodrug, a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate thereof, and a process for preparing the same, a pharmaceutical composition comprising the same, and use of the compound in the preparation of medicine preventing and treating tumors, wherein the substituents are as defined in the specification. 5. A compound according to claim 1 , a stereoisomer claim 1 , prodrug claim 1 , a pharmaceutically acceptable salts claim 1 , or a pharmaceutically acceptable solvate thereof claim 1 , which is selected from at least one of the group consisting of:{'sub': 1', '1', '3, '(1) in R, Zis independently selected from methoxy, ethoxy, isopropoxy or trifluoromethoxy, and/or Zis independently selected from 4-N,N-dimethylaminopiperidyl, 4-hydroxypiperidyl, morpholino, pyrrolidinyl, 3-N,N-dimethylpyrrolidyl, N-methylpiperazinyl, N-ethylpiperazinyl, N-acetylpiperazinyl, N-(2-hydroxyethyl)piperazinyl, N-(2-cyanoethyl)piperazinyl, N-(3-hydroxypropyl)piperazinyl, 4-(N-methylpiperazinyl)piperidyl, 4-(N-ethylpiperazinyl)piperidyl, 4-(N-acetylpiperazinyl)piperidyl, 4-(N-tert-butoxycarbonylpiperazinyl)piperidyl, 4-(N-(2-hydroxyethyl)piperazinyl)piperidyl, 4-(N-(2-cyanoethyl)piperazinyl)piperidyl, 4-pyrrolidylpiperidyl, N—(N-methyl-4-piperidyl)piperazinyl, N—(N-ethyl-4-piperidyl)piperazinyl, aminosulfonyl, methaminosulfonyl, cyclopropaminosulfonyl, piperidin-1-ylsulfonyl, 4-hydroxypiperidin-1-ylsulfonyl, 4-N,N-dimethylpiperidin-1-ylsulfonyl, pyrrolidin-1-ylsulfonyl, 3-N,N-dimethylpyrrolidin-1-ylsulfonyl, N-methylpiperazin-1-ylsulfonyl, N-ethylpiperazin-1-ylsulfonyl, morpholino-1-sulfonyl, hydroxycarbonyl, aminocarbonyl, methylaminocarbonyl, ethylaminocarbonyl, isopropylaminocarbonyl, cyclopropylaminocarbonyl, piperidin-1-ylcarbonyl, 4-hydroxypiperidin-1-ylcarbonyl, 4-N,N-dimethylpiperidin-1-ylcarbonyl, pyrrolidin-1-ylcarbonyl, 3-N,N-dimethylpyrrolidin-1-ylcarbonyl, N- ...

Factor IXa Inhibitors

The present invention provides a compound of Formula (I)

Drilling rig

A drilling rig includes a base section, a first section, a second section, a third section and a fourth section. For the base section upper region, a fixed pulley block and a guide pulley are installed. Except for the fourth section-crown block section, each section lower region is installed with a lifting lug for a movable pulley block installation for substantially vertical lifting. The crown block section is installed substantially vertical; the subsequent section is located substantially horizontal with the section front pillar upper region connecting to the previous section front pillar lower region. The previous section is substantially vertical lifted to draw the next section skidding into the base section and lifting substantially vertical with the previous section pillar lower region connected to the next section pillar upper region. Dismount the movable pulley block from the previous section and installed the movable pulley block with the adjacent section lifting lug.

TRAVEL ASSISTING METHOD AND TERMINAL

An embodiment of the present invention discloses a travel assisting method, including: extracting trip information from content saved in a terminal and saving the extracted trip information in a trip list; selecting the trip information from the trip list, automatically connecting to a preset network address or a preset server address, and searching by using part or all of content of each piece of the selected trip information as a key word, so as to obtain assisting information corresponding to the trip information; and generating prompting information. Correspondingly, an embodiment of the present invention further discloses a terminal. The present invention enables the terminal to automatically provide effective reference information for a user according to a trip of the user, solving the problem that an operation is troublesome and time-consuming when the user obtains trip-related assisting information by using the terminal. 1. A method performed by a mobile terminal comprising a memory and a processor , the method comprising:receiving, by the mobile terminal, a message from at least one server, wherein the message comprises at least one time and at least one payload;determining, by the mobile terminal, that at least part of the message from the at least on server matches a defined characteristic stored in the mobile terminal;extracting, by the mobile terminal, the trip information and the at least one time from the message using at least one set of expression forms stored in the mobile terminal, wherein the at least one set of expression forms are used to extract at least one set of trip information from the at least one payload;displaying, by the mobile terminal, the at least one set of trip information;establishing, by the mobile terminal, a connection to a travel server using the extracted information and obtaining related information from the extracted information; anddisplaying, by the mobile terminal, the extracted information concurrently with the ...

MAGNETIC SENSING APPARATUS AND MAGNETIC SENSING METHOD THEREOF

A magnetic sensing apparatus includes a third direction magnetic sensing component that includes a substrate and a pair of coupled magnetic sensing modules. A groove is set in surface of the substrate. The magnetic sensing module includes a magnetic conductive unit, where a main part of the magnetic conductive unit is set in the groove, and a part of it is exposed out the groove and to surface of the substrate, in order to collect magnetic field signal in the third direction and output the magnetic field signal. The magnetic conductive unit includes a magnetic material layer. The magnetic sensing module includes an inducing configured to receive the magnetic field signal in the third direction and measure corresponding magnetic field strength in the third direction by the magnetic field signal. The inducing unit includes a magnetic material layer. 1. A magnetic sensing apparatus , comprising a third direction magnetic sensing component , the third direction magnetic sensing component comprises a substrate and a pair of coupled magnetic sensing modules , a groove is set in surface of the substrate; andthe magnetic sensing module comprises:a magnetic conductive unit, main part of the magnetic conductive unit is set in the groove, and a part of it is exposed out the groove and to surface of the substrate, in order to collect magnetic field signal in the third direction and output the magnetic field signal; andan inducing unit setting on the surface of the substrate, to receive the magnetic field signal in the third direction and measure corresponding magnetic field strength in the third direction by the magnetic field signal; the inducing unit comprises a magnetic material layer, electrical resistance of the magnetic material in the magnetic material layer is variable with the magnetic field strength and direction, andwherein output magnetic signals in a first direction and/or a second direction for every pairs of coupled magnetic sensing modules are offset after the ...

COMBINATION DRUG THERAPY REDUCES PARP-1 RELATED DNA REPAIR AND INCREASES THE EFFICACY OF GENOTOXIC AGENTS

Various aspects and embodiments disclosed herein relate generally to the modelling, treatment, reduction of resistance to the treatment, prevention, and/or diagnosis of diseases characterized by the formation of cancers. Embodiments include methods of treating cancer, comprising the steps of: providing a patient diagnosed with cancer with a therapeutic regime that includes at least one therapeutically effective dose of at least one agent that reduces the activity of at least one DNA damage/repair pathway. Other embodiments include methods of treating cancer, comprising the steps of: treating a patient diagnosed with cancer with a combination of therapeutic agents that includes at least one therapeutically effective anti-cancer agent and at least one compound that reduces the activity of at least one DNA damage/repair pathway. Yet other embodiments include methods of reducing resistance to a genotoxic therapeutic, comprising the steps of: treating a patient at least one therapeutically effective dose of at least one agent that reduces at least one DNA damage/repair pathway. 1. A method of treating cancer , comprising the steps of:providing a patient diagnosed with cancer with a therapeutic regime that includes at least one therapeutically effective dose of at least one agent that reduces the activity of at least one DNA damage/repair pathway.2. The method of claim 1 , wherein the at least one agent that reduces the activity of the at least one DNA damage/repair pathway is selected from the group consisting of: a fatty acid synthase (FASN) inhibitor claim 1 , a poly ADP ribose polymerase (PARP) inhibitor claim 1 , a specific protein 1 (SP1) inhibitor claim 1 , FASN siRNA claim 1 , PARP siRNA claim 1 , and/or SP1 siRNA.3. The method of claim 1 , wherein the therapeutic regime further includes comprises at least one proton pump inhibitor.4. A method of treating cancer claim 1 , comprising the steps of:treating a patient diagnosed with cancer with a combination of ...

DIAMINO-ALKYLAMINO-Linked ARYLSULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS

Disclosed are compounds of Formula A, or a salt thereof, where Q, X, R1 and R2 are as defined herein, which compounds have properties for inhibiting Na 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A or their salts, and methods of treating pain (acute, post-operative, neuropathic), or cough or itch disorders using the same. 2) A compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein X is —CH═.3) A compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein X is —C(Cl)═.4) A compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein X is —C(F)═.5) A compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein X is —N═.6) A compound of or a pharmaceutically acceptable salt thereof claim 1 , wherein claim 1 , wherein Q is R—NH-D- claim 1 , wherein Ris —H claim 1 , lower alkyl claim 1 , or lower cycloalkyl and Dis linear- or branched-alkyl claim 1 , or a geminalcycloalkyl moiety of up to 6 carbon atoms.13) A composition comprising at least one compound of claim 13 , or a pharmaceutically acceptable salt thereof claim 13 , and at least one pharmaceutically acceptable excipient.14) A composition of comprising additionally an effective amount of at least one other pharmaceutically active ingredient which is: (i) an opioid agonist or antagonist; (ii) a calcium channel antagonist; (iii) an NMDA receptor agonist or antagonist; (iv) a COX-2 selective inhibitor; (v) an NSAID (non-steroidal anti-inflammatory drug); or (vi) paracetamol (APAP) claim 14 , and a pharmaceutically acceptable carrier.16) A method of treating a pain disorder claim 14 , or cough claim 14 , or acute itch or chronic itch disorder comprising administering to a patient in need thereof a therapeutically effective amount of a composition of .17) The composition of that provides an amount of said compound ...

System and method for providing point of interest related notifications

A system and method for providing point of interest related notifications within a vehicle that include receiving sensor data associated with an operation of the vehicle or a use of a component of the vehicle. The system and method also include storing a first geo-location of the vehicle based on the sensor data and determining if a subsequent geo-location of the vehicle is within a predetermined vicinity of at least one point of interest. The system and method further include providing at least one point of interest related notification associated with the at least one point of interest if it is determined that the subsequent geo-location of the vehicle is within the predetermined vicinity of the at least one point of interest.