Mach-zehnder type silicon optical waveguide switch based on narrow slit wave guide

The present invention discloses a Mach-Zehnder type silica optical waveguide switch based on narrow slit waveguide. After the wave splitting of the 3dB coupler which realizes power splitting function at the input end, a first group of two spot-size converting structures are respectively connected to the interference arms of two narrow slit waveguide structures, and then are connected to the output-end interference coupler through a second group of two spot-size converting structures. A random-structure 1*2 and 2*2 optical switches are formed through the different combination of two groups of spot-size converting structures. The present invention leads to a narrow slit waveguide and fills a low refraction ratio electrooptic material in the narrow slit. The modulation facility is enlarged, and the conventional indirect electrooptic modulation of carrier injection is switched to a direct electrooptic modulation. Besides, the silicon waveguides which are at two sides of the narrow slit and ...

Mathematical education drawing board

The utility model discloses a mathematical education drawing board, including the drawing board body, the top of drawing board body and at least one side indent respectively are equipped with the slide steering groove, the slide steering inslot slides and is equipped with circular angulation board, be equipped with the angular indexing line along the circumferencial direction on the circular angulation board, the outer terminal surface of circular angulation board is equipped with the installation axle perpendicularly, install epaxial rotation and install the drawing ruler, the chi body length degree of drawing ruler is less than the height of drawing board body, the drawing ruler is equipped with the marking off cylindrical void along the length direction of the chi body, the width of marking off cylindrical void and the diameter looks adaptation of chalk, demountable installation has the chalk mount pad on the drawing ruler, be equipped with double -layered chalk hole on the chalk mount ...

Detachable sun-shading and rain-shading helmet

The invention discloses a detachable sun-shading and rain-shading helmet. The helmet is convenient to use and store. The helmet comprises a body, a first rotating piece, and a wind shield cover, wherein the wind shield cover is pivoted to the body through the first rotating piece. The helmet also comprises a detachable shading structure, and the shading structure comprises a second rotating piece, a visor, a pair of fixed lugs, and a pair of fixed insertion parts, wherein the pair of fixed lugs are respectively disposed on the pair of fixed insertion parts, and the section of each fixed insertion part is shaped like n. The visor is pivoted to the pair of fixed lugs through the second rotating piece. Compared with a conventional helmet, the helmet can determine whether the shading structure needs to be used or not through the detachable shading structure according to the specific weather condition, and achieves a sun-shading and rain-shading function under the condition of guaranteeing the ...

Nonreciprocal device based on magneto-optical resonator cavity

METHOD FOR MAKING NATURAL CASHEWNUT MILK (JUICE)

Process of preparing a natural cashew juice beverage which is mixing well, without pigmentary and antiseptic is involved with that cashews-selected are treated by microwave, milling and adding water, centrifugal separation, emulsifying, milling for colloidization, adding sugar and flavour, packing, sterilizing. This beverage is keeping natural cashew juice flavcour, it has a delicate fragrance and tasty and rich nutrients.

Silicon carbide seed crystal bonding and fixing method and fixing structure

The invention discloses a silicon carbide seed crystal bonding and fixing method and a silicon carbide seed crystal bonding and fixing structure, an adhesive-free bonding process is used, and silicon carbide seed crystals and silicon carbide polycrystalline blocks are subjected to low-pressure and high-temperature treatment, react and then are bonded with each other. According to the invention, the bonding firmness and stability are improved, and the method is especially suitable for bonding large-size silicon carbide seed wafers; no adhesive is introduced in the bonding and fixing method, and the polycrystalline silicon carbide ceramic block is used, so that the polycrystalline silicon carbide ceramic block has almost no thermal expansion coefficient difference with the silicon carbide seed crystal at high temperature; compared with a traditional adhesive for bonding, the bonding strength is higher, and the risk that the stress of the seed crystal is increased due to the difference of ...

SUPERHIGH TORSIONAL STRENGTH, METALLIC AND AIRTIGHT DRILLROD COUPLER

The present invention discloses a superhigh torsional strength, metallic and airtight drillrod coupler, comprising: an externally threaded coupler, having a radially outward outer shoulder and an inner end face, with an externally threaded section and a first sealing face in sequence in axial direction of the externally threaded coupler; and an internally threaded coupler, the internally threaded coupler having a radially inward inner shoulder and an outer end face, with a second sealing face and an internally threaded section to be engaged with the externally threaded section being provided in sequence in the axial direction of the internally threaded coupler. The inner end face mates with a shoulder face of the inner shoulder, and the outer end face mates with a shoulder face of the outer shoulder. The first sealing face and the second sealing face are both sloped faces, and are in an interference-fit sealed connection with each other.

METHOD FOR MANUFACTURING SUPER 13CR TOOL COUPLER

Disclosed is a method for manufacturing a super 13Cr tool coupler, comprising the following steps: manufacturing a blank; forging the blank; heating the forged blank to 600ºC to 700ºC for stress-relief annealing; quenching; and tempering. The method can be used to manufacture a super 13Cr tool coupler with a mechanical strength of up to 110ksi.

Railway vehicle and brake pull rod device thereof

The invention discloses a brake pull rod device. The brake pull rod device is simple and compact in structure, low in weight, good in braking effect, high in reliability, usability, maintainability and safety, capable of buffering longitudinal impact to and vibration of a train and capable of compensating for and regulating movement of a brake. When being applied to a braking system of the medium and lower speed magnetic-levitation train, the brake pull rod device can optimize performance of the magnetic-levitation train, buffer the longitudinal impact to the train, improve running smoothness and comfort of the magnetic-levitation train, compensate for and regulate the amount of movement generated by the brake when the train is braked, reduce noise generated due to movement of a pull rod, and improve running quality of the magnetic-levitation train. The invention further discloses a railway vehicle provided with the brake pull rod device.

Method and portable device for measuring pol of fruit

The embodiment of the invention discloses a method of using a portable device to measure the pol of fruit. The method comprises the following steps: generating a measurement index required by the measurement of the pol of fruit according to the type of fruit to be measured; according to the measurement index, emitting a first near infrared laser by using the portable device to target the geometric centre of the fruit to be measured; receiving a second near infrared laser, obtaining transmissivity according to the second near infrared laser and the first near infrared laser and calculating thepol of fruit to be measured according to the transmissivity. The embodiment of the invention also discloses the portable device for measuring the pol of fruit. The embodiment of the invention can be utilized to realize the function of measuring pol by using a mobile phone and other portable devices.

Lithium cell electrode material life -span detecting system based on creep deformation detects

The utility model provides a lithium cell electrode material life -span detecting system based on creep deformation detects, characterized by it includes electrolytic bath (2), laser instrument (1) and CCD camera (3), electrolytic bath (2) in install and be used for the working electrode that detects, the battery electrode with fill discharge device and be linked together, during laser instrument (1) is arranged in shining the battery electrode surface of electrolytic bath and incides the CCD camera with the reverberation, obtain the deformation on battery electrode surface after the size creep on the battery electrode surface that CCD camera (3) will regularly absorb is sent into and is handled in the computer to obtain the life -span of battery electrode. The utility model discloses simple structure makes convenient to use.

Composition splint board hip bone supporting stand

Purinones as ubiquitin-specific protease 1 inhibitors

The application relates to inhibitors of USP1 useful in the treatment of cancers, and other USP1 associated diseases and disorders, having the Formula: (I), where R ...

SYMMETRIC OR SEMI-SYMMETRIC COMPOUNDS USEFUL AS IMMUNOMODULATORS

A compound having Formula I:(I), or a pharmaceutical acceptable salt thereof. A is a bivalent arene or a bivalent heteroarene; Ring B and Ring B' are independently a 6-membered aromatic hydrocarbon ring, a 6-membered heterocyclic ring, a 8- to 10-membered aromatic hydrocarbon ring, or a 8- to 10-membered heterocyclic ring; Y and Y' are independently, null (direct bond), -CHR1-, -CH2-CH2-, -NR1-, -0-, -OCH2-, -CH2O-, -SCH2-, -CH2S-, -SOCH2-, -CH2SO-, or -SO2CH2-, and R1 is H, C1-6 alkyl, or C3-6 cycloalkyl.

Iron ore tunnel cave magnetizing roasting self -heating balancing unit

The utility model discloses an iron ore tunnel cave magnetizing roasting self -heating balancing unit, outside at tunnel cave heating reducing zone is equipped with heat accumulation formula heat exchanger, the high temperature flue gas inlet of heat accumulation formula heat exchanger links to each other with the exhaust port of tunnel cave heating reducing zone, the exhanst gas outlet department of heat accumulation formula heat exchanger is equipped with heating reducing zone induced -draft fan, the cold air intlet department of heat accumulation formula heat exchanger is equipped with the air -blower, the hot -air export of heat accumulation formula heat exchanger links to each other with the hot -blast passageway that infeeds that sets up on tunnel cave heating reducing zone lateral wall through hot -blast pipeline. The utility model discloses an adjusting kiln end exhaust exhaust gas volumn and heating reducing zone exhaust exhaust gas volumn proportion, having reduced the tunnel ...

Process for producing zero slot directional coupling light switch

Hierarchical material distribution reduction method for sponge iron tunnel kiln and tunnel kiln applying same

The invention discloses a hierarchical material distribution reduction method for a sponge iron tunnel kiln and the tunnel kiln applying the hierarchical material distribution reduction method. Materials to be reduced are divided into different grades according to the particle size range, the materials, in different grades, to be reduced are respectively mixed with reducers to form mixed materials, the mixed materials are tiled on a table board of a tunnel kiln car in layers, the particle size range of the materials to be reduced in each layer is gradually increased from the bottom layer to the top layer, and the kiln car carries out reduction by passing through a preheating zone, a roasting zone and a cooling zone in the tunnel kiln after the materials are tiled. By adopting the hierarchical material distribution reduction method, iron ores in different particle sizes can be uniformly reduced during reduction from the upper layer to the bottom layer and in a process of oxygenating for ...

Steel pipe jet printing quality online detection device and method

The invention discloses a steel pipe jet printing quality on-line detection device which comprises a visual identification assembly arranged on a lifting mechanism, a linear scanning dome light source arranged on the rear side of a jet printing head, a linear array camera arranged above the linear scanning dome light source and a linear array camera arranged above the linear scanning dome light source. The linear scanning dome light source comprises an arc-shaped diffuse reflection face corresponding to the steel pipe, upward light sources arranged at the bottoms of the two sides of the arc-shaped diffuse reflection face respectively, and a shooting window formed in the top of the arc-shaped diffuse reflection face and matched with the linear array camera. The invention further discloses an online detection method. According to the invention, manual work is replaced by machine vision, real-time character-by-character photographing and recording are realized, the jet printing quality is ...

Active and passive integrated composite material structure health monitoring method and system

The invention relates to the field of structure monitoring, in particular to an active and passive integrated composite material structure health monitoring method and system.The method comprises the steps that an active sensor network and a passive sensor network monitor an impact event in real time to generate a stress wave signal, and the stress wave signal is transmitted to a host unit; the host unit analyzes the stress wave signal to generate control information, and transmits the control information to the active and passive sensor network to realize conversion from passive monitoring to active detection; and the active sensed network actively scans the composite material structure to obtain a guided wave signal, and transmits the guided wave signal to the host unit so as to carry out active and passive integrated detection on the composite material. According to the method, active damage monitoring and passive impact monitoring are combined, an active and passive integrated structure ...

Isothiazolopyrimidinones, pyrazolopyrimidinones, and pyrrolopyrimidinones as ubiquitin-specific protease 7 inhibitors

The disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where R1, R2, R3, R4, R5, R5′, X1, X2, X3, n, and m are described herein.

PYRROLO AND PYRAZOLOPYRIMIDINES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS

The invention relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: (I) where m, n, X1, X2, R1-R5, R5' and R6 are described herein.

METHOD FOR MANUFACTURING SUPERIOR 13CR THICKENED DRILLROD

A method for manufacturing a superior 13Cr thickened drillrod comprises the following steps: firstly, thickening the ends of a steel tube with a composition so as to obtain a drillrod with thickened ends, the composition in percentage by weight being: C: 0.01-0.05%, Si<=0.5%, Mn: 0.2-1.0%, Cr: 12-14%, Mo: 1-3%, Ni: 4-6%, and a balance of Fe and inevitable impurities; after heating the tube as a whole to 950-1000°C, air cooling same and tempering same at 600-650°C; and machining the two thickened ends respectively into an externally threaded drillrod coupler and an internally threaded drillrod coupler; wherein the tube end thickening is an external thickening, including three rounds of heating and three rounds of thickening, with at least one pass of deformation for each round, and the heating temperature being 1150-1200°C for each round; and the upsetting pressure for the first round of external thickening is 180-220 bars, the upsetting pressure for the second round of external thickening is 180-220 bars, and the upsetting pressure for the third round of external thickening is 140-180 bars. The drillrod according to the present invention can be used not only as a drillrod but also as an oil tube, fulfilling requirements of the exploration operation of a CO2-containing gas field of compact sandstone with a high yield.

Monitoring system for carrier-rocket launch fuel-gas flow field

The invention discloses a monitoring system for a carrier-rocket launch fuel-gas flow field. The monitoring system includes a first test main array group and a second test main array group, wherein the first test main array group includes an in-diversion-hole fuel-gas flow field test array, a table-board fuel-gas flow field test array and an on-cross-beam fuel-gas flow field test array. The second test main array group includes a near-diversion-trench-entrance fuel-gas flow field parameter test array, a diversion-trench-drainage-guide-face fuel-gas flow field parameter test array, a guide-trench-top fuel-gas flow field parameter test array and a diversion-trench-side-face fuel-gas flow field parameter test array. The test scheme of the carrier-rocket launch fuel-gas flow field is applicable to carrier-rocket launch fuel-gas flow field testing and fuel-gas-flow ablation characteristic assessment and capable of being transplanted conveniently into a shrinkage-scale launch simulation test ...

Safety monitoring device of fire fighting equipment

The invention discloses a safety monitoring device of fire fighting equipment in the technical field of monitoring equipment, which comprises a monitoring main body and a wire, one end of the wire is fixedly connected with an intelligent regulator, one end of the intelligent regulator is fixedly connected with a plug, one side of the monitoring main body is fixedly connected with a shell, one side of the shell is fixedly provided with a cover plate, and the cover plate is fixedly connected with the wire. An integrated switch is fixedly installed on one side of the cover plate, and a storage motor and a guide rod are fixedly installed on the other side of the cover plate. According to the safety monitoring device of the fire fighting equipment, through cooperation of an integrated switch, a storage motor and a wire shaft, one-key automatic winding and unwinding of a wire can be achieved, the burden of a user for storing the wire can be effectively relieved, meanwhile, through cooperation ...

QUINAZOLINONES AND AZAQUINAZOLINONES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS

... where R1, R2, R3, R4, R4′, X1, Y1, Y2, Y3, Y4, n, and m are described herein.

Symmetric or semi-symmetric compounds useful as immunomodulators

A compound having Formula I:(I), or a pharmaceutical acceptable salt thereof. A is a bivalent arene or a bivalent heteroarene; Ring B and Ring B' are independently a 6-membered aromatic hydrocarbon ring, a 6-membered heterocyclic ring, a 8- to 10-membered aromatic hydrocarbon ring, or a 8- to 10-membered heterocyclic ring; Y and Y' are independently, null (direct bond), -CHR ...

A method for detecting recessive albino mutation of Ictalures punctatus caused by gene HPS4

Disclosed is a method for detecting recessive albino mutation of Ictalures punctatus caused by gene HPS4; according to the method disclosed by the invention, a pair of specific primers are utilized, nucleotide sequences of the specific primers are shown as SEQ ID NO.1 and SEQ ID NO.2; the specific primers are utilized to perform PCR amplification on the ictalures punctatus HPS4 gene; an amplification product is used for gel electrophoresis; genotyping results are judged according to the band number and the sizes appearing in an electrophoresis pattern: an albino individual has 99bp base deletion and only has a smaller 150bp band; an HPS4 gene of a normal individual has no change; and the normal individual only has a larger 249bp band; a gene single strand of a recessive albino mutation carrier lacks 99bp, so that the smaller band 150bp and the larger band 249bp can exist at the same time; said method disclosed by this invention can quickly and accurately detect the recessive albino mutation carrier with HPS4 gene and has important application value in an ictalures punctatus breeding process. 1

DNA POLYMERASE IIIC INHIBITORS AND USE THEREOF

The present invention relates to compounds and methods useful for inhibiting the DNA polymerase IIIC enzyme. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of Gram-positive bacterial infections.

PURINONES AS UBIQUITIN-SPECIFIC PROTEASE 1 INHIBITORS

The application relates to inhibitors of USP1 useful in the treatment of cancers, and other USP1 associated diseases and disorders, having the Formula: (I), where R1, R2, R3, R3', R4, R5, X1, X2, X3, X4, and n are described herein.

Shaft furnace of efficiently controlling iron ores to be magnetized and roasting method thereof

The invention provides a shaft furnace of efficiently controlling iron ores to be magnetized and a roasting method thereof, and the shaft furnace can be used for improving the magnetizing uniformity inside and outside the ores, further shortening the ore roasting time, improving the output of the shaft furnace and lowering the magnetizing and roasting cost. Combustion chambers on both sides of a heating section are vertically divided into three layers, and the combustion chambers in three layers are in gradient distribution from small to large from top to bottom of the shaft furnace, heat energy distribution of the heating section of the shaft furnace is optimized, and the uniformity of the heating temperature of the magnetizing and roasting ores of the shaft furnace is improved, so that the problem of ore cementation caused by non-uniform heating temperatures of the ores in the furnace is solved. The magnetizing and roasting temperature of the iron ores is improved from originally about ...

Curved surface solar car skylight

The utility model relates to a sunroof structure of solar energy power generation function specifically is a curved surface solar car skylight. It is including curved surface's individual layer or double -deck skylight glass, and compound between the inboard or double -deck skylight glass of individual layer skylight glass have a solar wafer, solar wafer has plated first electrode, photoelectric conversion layer and second electrode including the ultra -thin glass substrate that one deck curved surface is the same or close with skylight glass in proper order on ultra -thin glass substrate, solar wafer passes through bond line and the bonding of skylight glass. The utility model discloses closing that the piece in -process can significantly reduce because in the production process that results in of the stress damaged scheduling problem of lobe of a leaf has improved the yields, manufacturing cost has been reduced.

Electro optic modulator based on horizontal narrow slit flat-plate and photon crystal linear defect wave-guide

The invention discloses an electro-optic modulator which is based on a horizontal narrow seam flat plate and photon crystal linear defect waveguide, comprising 1 multiplied by 2 couplers, two interference arm waveguides, and an Mach-Zehnder electro-optical modulator consisting of 2 multiplied by 1 couplers and an electrode. Two interference arm waveguides with the same structure adopt a horizontal narrow seam flat plate waveguide structure in the vertical direction; the interference arm waveguide adopts a two-dimensional photon crystal linear detect waveguide structure in the horizontal direction. A composite structure consisting of a semiconductor material layer and an electro-optical material layer is a core layer of an optical waveguide. The forbidden band of the photon crystal period structure is used in the horizontal direction and the strong restriction effect of the narrow seam waveguide is used in the vertical direction so as to restrict the optical field distribution. The composite ...

Self-fluxing composite metallized pellet and production process thereof

The invention relates to the technical field of metallurgy and mineral engineering, and discloses a self-refluxing composite metallized pellet and a production process thereof. The self-refluxing composite metallized pellet comprises an inner core and an outer shell, wherein the inner core is formed by mixing iron ore concentrate, limestone, coal powder and cement in a proportion of 330:(300-350):(80-120):(6-9); the outer shell is formed by mixing iron core concentrate and bentonite in a mass ratio of 1320:(22-25), the grain size of the inner core is 20-25mm, and the thickness of the outer shell is 5-10mm. The production process for the self-refluxing composite metallized pellet comprises the following steps: preparing the inner core and packaging the outer shell to form a composite metallized pellet; packaging the composite metallized pellet with a reducing layer, distributing and drying the composite metallized pellet, reducing and roasting the composite metallized pellet, cooling and ...

Designing method of weak-limit multimode optical interferometer

The method for designing weak-bound multimode optical interferometer includes: defining number of paths of said weak-bound multimode optical interferometer, width of optical interference range, optical refractivity of waveguide layer material and wave length of applicable light. Said invention provides three formulae, it utilizes formula (1) to calculate optical refractivity of cladding layer, utilizes formula (2) to calculate effective width of optical interference range, finally utilizes the number of paths of optical output to calculate the position of optical output waveguide and uses formula (3) to calculate length of optical interference range. Said method is simple, and the uniformity of the designed device can be greatly raised, when the number of optical waveguide paths is upto 128 paths, the above-mentioned properties can be rettained, and is can easily integrated with other device.

Bottle opening liquid distributor

The utility model discloses a bottle opening liquid distributor. The liquid distributor comprises a liquid distributor body, a liquid taking part and a liquid distributing part, a shell is arranged outside the liquid distributor body; a piston assembly is arranged in the liquid distributor body. The piston assembly comprises a piston body connected with a pipe cavity of the liquid distributor bodyin a sealed mode, a piston rod connected with the piston body and a horizontal piston head connected with the piston rod, one end of the piston head penetrates through the side edge of the shell, andthe other end of the piston head is connected with the bottom of the shell through an elastic piece; wherein the shell is connected with a reagent bottle through a bottle plug, the upper part of thebottle plug is movably connected with the shell, and the lower part of the bottle plug is provided with an internal thread structure; and one-way valves are arranged in the liquid taking part and theliquid ...

Multi-stage reduction heat supply heat storage type gas-based shaft furnace direct reduction process

The invention discloses a multi-stage reduction heat supply heat storage type gas-based shaft furnace direct reduction process. A heat storage type gas-based shaft furnace comprises a material distribution mechanism, a reduction mechanism, a heat storage type heating mechanism, a reducing gas conveying mechanism and a fuel gas conveying mechanism. The lower end of the distribution mechanism is communicated with the top of the reduction mechanism; the reduction mechanism comprises a preheating and pre-reduction section, a heating and reduction section, a cooling section and a discharge hole from top to bottom; a heat accumulating type heating mechanism is wrapped outside the heating and reducing section; the reducing gas conveying mechanism penetrates through the heat accumulating type heating mechanism and is connected with the reducing mechanism through multiple pipelines in a grading manner; part of coal gas generated by the reduction mechanism enters the reduction gas conveying mechanism ...

ISOTHIAZOLOPYRIMIDINONES, PYRAZOLOPYRIMIDINONES, AND PYRROLOPYRIMIDINONES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS

... where R1, R2, R3, R4, R5, R5′, X1, X2, X3, n, and m are described herein.

Pyrrolo and pyrazolopyrimidines as ubiquitin-specific protease 7 inhibitors

The invention relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: (I) where m, n, X ...

Purinones as ubiquitin-specific protease 1 inhibitors

The application relates to inhibitors of USP1 useful in the treatment of cancers, and other USP1 associated diseases and disorders, having the Formula: (I), where R ...

SUPERHIGH TORSIONAL STRENGTH, METALLIC AND AIRTIGHT DRILLROD COUPLER

The present invention discloses a superhigh torsional strength, metallic and airtight drillrod coupler, comprising: an externally threaded coupler, having a radially outward outer shoulder and an inner end face, with an externally threaded section and a first sealing face in sequence in axial direction of the externally threaded coupler; and an internally threaded coupler, the internally threaded coupler having a radially inward inner shoulder and an outer end face, with a second sealing face and an internally threaded section to be engaged with the externally threaded section being provided in sequence in the axial direction of the internally threaded coupler. The inner end face mates with a shoulder face of the inner shoulder, and the outer end face mates with a shoulder face of the outer shoulder. The first sealing face and the second sealing face are both sloped faces, and are in an interference-fit sealed connection with each other.

Website classifying method

The invention discloses a website classifying method. The website classifying method comprises the following steps: obtaining multidimensional attributes of a website and representing the multidimensional attributes by utilizing a set; carrying out self-coding characteristic learning for the set that represents the multidimensional attributes; carrying out website clustering learning by utilizing a self-coding learning result to obtain a support vector machine (SVM) used for carrying out website classifying; a step S104: while classifying any unmarked website, firstly carrying out a step S101 and a step S102 to obtain the self-coding learning result corresponding to the web site; and then, inputting the structure into the SVM obtained in the step S103, and finally carrying out website classifying to obtain the category of the website. The website classifying method disclosed by the invention can efficiently and accurately classify the website according to the industry category, and also ...

Spiropyran photochromic compound and preparation method thereof

The invention relates to a spiropyran photochromic compound shown as formula I. The preparation method includes: subjecting 3, 4-dimethoxy benzophenone and butyric acid dimethyl ester to condensation reaction under an alkaline condition to obtain a compound s2, conducting acetic anhydride reflux cyclization to obtain 4-acetoxy-6, 7-dimethoxy-1-phenyl-2-naphthoic acid methyl ester, then performing alkaline hydrolysis to obtain 4-hydroxy-6, 7-dimethoxy-1-phenyl-2-naphthoic acid s4, subjecting the compound s4 to cyclization under an acidic condition to obtain an intermediate 5-hydroxy-2, 3-dimethoxy-7H-benzo[c]fluorine-7-one, then carrying out reaction with a methyl Grignard reagent to obtain 2, 3-dimethoxy-7-methyl-7H-benzo[c]fluorene-5, 7-diol, and finally under the catalysis of p-toluenesulfonic acid, reacting 2, 3-dimethoxy-7-methyl-7H-benzo[c]fluorene-5, 7-diol with 1, 1-bis(4-methoxyphenyl)-2-propyne-1-ol to generate the compound shown as formula (I). The compound can change from colorless ...

High-strength composite metallized pellets produced by using iron-containing metallurgical dust and production process thereof

The invention relates to the technical field of metallurgy and mineral engineering and discloses high-strength composite metallized pellets produced by using iron-containing metallurgical dust and a production process thereof. Each high-strength composite metallized pellet comprises an internal core and an external shell, wherein the internal core is composed of iron-containing metallurgical dust, the iron-containing metallurgical dust is a mixture of blast furnace gas dust, converter OG sludge and converter secondary dust removing dust which are in a mass ratio of 650:(580-610):(55-70), the external shell is made from a mixture of iron ore concentrate and bentonite which are in a mass ration of 650:(13-18), the mass ratio of the iron-containing metallurgical dust to iron ore concentrate is (60-65):(35-40), the particle size of the internal core is 20-25mm, and the thickness of the external shell is 5-10mm. The preparation process of the high-strength composite metallized pellet comprises ...

Polarization laser acupuncture and moxibustion therapeutic instruments

The invention discloses a polarization laser acupuncture and moxibustion therapeutic apparatus. One end of the controller of the laser therapeutic apparatus is connected with a semiconductor laser by a power supply; the laser transmitted from the semiconductor laser goes through a polarizer and a polarization LCD mofulator adhered on the surface of the polarizer; the planes of the polarizer and the polarization LCD mofulator are vertical to the light beams transmitted from the semiconductor laser; the permeable vibration direction of the polarizer and the anchoring direction of the polarization LCD mofulator form a 45-degree angle; the laser transmitted from the polarization LCD mofulator enters into a condensing optical lens unit; the other end of the controller of the laser therapeutic apparatus is connected with the polarization LCD mofulator. Under control of a control circuit, the laser outputting special luminous intensity wave enters into the polarization mofulator; the polarization ...

Rotary kiln magnetizing roasting heat-source-free continuous reduction apparatus and use method

The present invention relates to the technical field of smelting equipment, and discloses a rotary kiln magnetizing roasting heat-source-free continuous reduction apparatus and a use method. The rotary kiln magnetizing roasting heat-source-free continuous reduction apparatus comprises a tank, a material inlet and a material outlet, wherein the upper cavity of the tank is a continuous reduction region, the lower cavity is a heat exchange region, a heat exchange pipe is arranged in the heat exchange region, the heat exchange pipe inlet end is arranged on the lower side of the tank wall of the tank, the heat exchange pipe outlet end is arranged on the middle portion of the tank wall of the tank, the upper cavity tank wall of the tank is further provided with a reduction coal gas outlet, and the material inlet end and the rotary kiln outlet end are connected. According to the present invention, after being subjected to 20-30% of pre-reduction in the rotary kiln, iron ore enters the tank of ...

Composition splint board hip bone supporting stand

The present invention is one combined hip splint support as medical equipment. Below the support rod, there are rotating regulation board and traction device comprising traction rope, tension meter,ankle sleeve, tension regulator and tension deflector. The triangular arch side splint and the triangular arch front splint are connected via angle regulating ring, support and straight rod, and thesupport rod is matched movably with the straight rod via the U-shaped cross bar and connecting rings. The present invention has reasonable structure and may be used in sustained traction treatment.The combination of dynamic and static treatment results in raised treatment quality.

Smoke desulfurization dust remover of coal boiler

Anticancer sustained-release gel injection containing neonatal blood vessel inhibitor

A sustained-release gel injection comprises angiogenesis inhibitor, amphiphilic block copolymer, solvent and release regulator, wherein the mixture of amphiphilic block copolymer and solvent has temperature sensitive gelatinization characteristic, and can automatically become non-flowing degradable water insoluble gel, which can locally and slowly release drug at tumor foci for several weeks to several months, after injection into body. The preparation can be injected into or around tumor for treating solid tumors at different stages and metastatic tumors with remarkably reduced systemic toxicity of drug. The angiogenesis inhibitor is selected from alemtuzumab,ibritumomab, bevacizumab, rituximab, gemtuzumab ozogamicin, panitumumab, trastuzumab, celebrex, refecoxib, tositumomab, endostatain, engiostatin, toxitumomab, and cetuximab. The preparation has effects of controlling residual tumor cell relapse after operation and tumor can not be excised via operation, controlling complications at ...

Wavelength dispersion device based on bent waveguide integrated grating

The invention discloses a wavelength dispersion device based on integrated grating on bending waveguide, comprising input waveguide on integrated optical substrate, bending strip light waveguide with multiple grid lines, sectorial free transmission region located on the concave side of the bending strip light waveguide, a series of output light waveguides located at or near focal plane of the bending strip light waveguide. Because of diffraction of different grid lines, the light transmitted in the strip light waveguide forms diffracted lights and the diffracted lights interfere mutually and are focused on the focal plane of the bending strip light waveguide so that lights of different lengths are focused to different points and exported through the output light waveguide. And the invention has features of compact structure, looser making process requirements, more flexible making process, and lower making cost.

Method, device and computer-readable storage medium for guiding symbolic execution

The present disclosure provides a method, apparatus, device and computer-readable storage medium for guiding symbolic execution. According to embodiments of the present disclosure, it is possible to determine the specific code region of the program, and obtain the program loop output of the program corresponding to the specific code region of the program by using the program inverse analysis method, so that it is possible to obtain the program loop input of the program corresponding to the specific code region by using the program loop predictor according to the program loop output of the program. In this way, the obtained program loop input of the program corresponding to the specific code region may be used to guide the symbolic execution to filter out impossible execution paths and jump out of the program code and reach the specific code region, thereby improving the reliability of the symbolic execution.

Quinazolinones and azaquinazolinones as ubiquitin-specific protease 7 inhibitors

The present disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where R1, R2, R3, R4, R4′, X1, Y1, Y2, Y3, Y4, n, and m are described herein.

METHOD FOR MANUFACTURING SUPER 13CR TOOL COUPLER

Disclosed is a method for manufacturing a super 13Cr tool coupler, comprising the following steps: manufacturing a blank; forging the blank; heating the forged blank to 600ºC to 700ºC for stress-relief annealing; quenching; and tempering. The method can be used to manufacture a super 13Cr tool coupler with a mechanical strength of up to 110ksi.

Iron and steel metallurgy fly ash pellet binder as well as preparation and use methods thereof

The invention provides a ferrous metallurgy fly ash pellet binder and a preparation and use method thereof, and aims at solving the problems that an existing organic polymer binding material is high in cost and low in solid content, and an inorganic binding material is low in binding strength and large in adding amount. Wherein a preparation method of the binder comprises the following steps: taking 250-350 parts of corn starch, 650-750 parts of water, 2-4 parts of amylase and 12-18 parts of water glass, adding the starch into the water to prepare starch slurry, adding an amylase solution with the concentration of 5% into the starch slurry, stirring, heating to 90-95 DEG C, carrying out heat preservation reaction for 40-45 minutes, adding 12-18 parts by weight of water glass into the starch slurry, stirring for 20-25 minutes, and cooling to room temperature to obtain the binder. The binder for the iron and steel metallurgy fly ash pellets is prepared. The binder for the iron and steel metallurgy ...

ISOTHIAZOLOPYRIMIDINONES, PYRAZOLOPYRIMIDINONES, AND PYRROLOPYRIMIDINONES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS

... where R1, R2, R3, R4, R5, R5′, X1, X2, X3, n, and m are described herein.

Pyrrolo and pyrazolopyrimidines as ubiquitin-specific protease 7 inhibitors

The invention relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: (I) where m, n, X ...

METHOD FOR MANUFACTURING SUPERIOR 13CR THICKENED DRILLROD

A super 13Cr upset drill pipe manufacturing method, comprising the following steps: conducting end upset treatment of a steel pipe having the following weight percentages of compositions to manufacture an upset-end drill pipe: C=0.01-0.05%, Si=0.5%, Mn=0.2-1.0%, Cr=12-14%, Mo=1-3%, Ni=4-6%, and the balance being Fe and unavoidable impurities; heating the whole drill pipe to 950-1000°C, conducting air cooling, and then tempering at 600-650°C; the two upset ends are respectively processed into an external threaded drill pipe joint and an internal threaded drill pipe joint; the end upset treatment is external upset, including three times of heating and three times of upset, with at least one-pass deformation each time and the heating temperature being 1150-1200°C each time; the first external upsetting pressure is 180-220 bar; the second upsetting pressure is 180-220 bar; and the third upsetting pressure is 140-180 bar. The drill pipe manufactured via the process can function as both a drill ...

Method for indicating uplink hybrid automatic repeat request information, mobile terminal and base station

The invention provides a method for indicating uplink hybrid automatic repeat request information, a mobile terminal and a base station, and belongs to the technical field of communication. The method comprises the following steps that: the base station detects whether the received data transmitted by the mobile terminal is correct; if the received data is incorrect, the base station detects whether the mobile terminal has resources for synchronous hybrid automatic repeat at the current scheduling moment; if the terminal has no resource for synchronous hybrid automatic repeat at the current scheduling moment, the indicating type of the uplink hybrid automatic repeat request information which is transmitted to the mobile terminal by the base station is to wait for synchronous hybrid automatic repeat, wherein the synchronous hybrid automatic repeat comprises synchronous non-adaptive hybrid automatic repeat and synchronous adaptive hybrid automatic repeat; therefore, the resource conflict ...

Orienting mating and breeding method for Ictalurus punctatus

The invention relates to a directional hybridization propagation method of Ictalurus punctatuses. The method mainly comprises the following steps: step 1, the Ictalurus punctatuses are put in a copulatory device, and brightness and noise of the copulatory device are controlled; and step 2, laid eggs are put in single hatching troughs for hatching so as to obtain ideal Ictalurus punctatus fries. The invention is beneficial to improve the quality of offspring and prevent a degeneration phenomenon due to close propagation from generating.

Full-automatic double-station welding steel belt bundling machine for profile steel and bundling method

The invention relates to the technical field of steel belt bundling devices, and discloses a full-automatic double-station welding steel belt bundling machine for profile steel and a bundling method.The full-automatic double-station welding steel belt bundling machine for profile steel comprises a rack and a bundling channel, a plurality of conveying roller ways are arranged on the bundling channel at intervals, and the conveying roller ways convey bundling materials along the bundling channel; a clamping station is arranged between every two adjacent conveying roller ways, a first clamping device and a second clamping device are arranged on the machine frame and located on the two sides of the clamping stations respectively, the first clamping device moves horizontally towards the second clamping device, a first steel belt bending device is arranged on the first clamping device, and a second steel belt bending device is arranged on the second clamping device. The first clamping device ...

CARBONATE-BASED ANTI-CAKING AGENT WITH REDUCED GAS RELEASE

数学模型在企业数字化制造集成技术中的应用

The present invention relates to the application of mathematical model in enterprise manufacture digitalizing integration technology. The present invention includes the following steps: establishingone mathematical model to form equipment structure of m*n units before the integration, with each unit including 4 parameters; classifying parts in the characteristics, laying out the computer aided technological process, data statistic, and dividing the technological process to specific units based on the four parameter requirement. The present invention realizes the efficient computerized management, resource sharing, raise work efficiency, optimize the technological process, and shorten production period.

Preparation method of cross silt wave guide based on oxygen implantation technology

The invention discloses a preparation method of cross silt wave guide based on oxygen implantation technology. The preparation method comprises the following steps of: after forming a first SiO2 layer on a top layer silicon of a silicon wafer on an insulator, removing two sides of the first SiO2 layer; removing a top layer silicon of the silicon wafer on the insulator, wherein the top layer silicon is not protected by the first SiO2 layer; removing a middle section area of the first SiO2 layer, making a second SiO2 layer by internal oxidation of the top layer silicon; coating a layer of photoresist on the surface of the silicon wafer on the insulator so as to protect an insulation layer of the silicon wafer on the insulator, and then removing the second SiO2 layer to enable the top layer silicon to internally form a horizontal silt; removing the photoresist to protect the insulation layer, making a third SiO2 layer on the top layer silicon and removing a middle area of the third SiO2 layer ...

Quinazolinones and azaquinazolinones as ubiquitin-specific protease 7 inhibitors

The present disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where R1, R2, R3, R4, R4′, X1, Y1, Y2, Y3, Y4, n, and m are described herein.

Quinazolinones and azaquinazolinones as ubiquitin-specific protease 7 inhibitors

The present disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where R 1 , R 2 , R 3 , R 4 , R 4′ , X 1 , Y 1 , Y 2 , Y 3 , Y 4 , n, and m are described herein.

Thienopyrimidinones as ubiquitin-specific protease 7 inhibitors

The disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where R1, R2, R3, R5, R5′, X1, X2, n, and m are described herein.

Isothiazolopyrimidinones, pyrazolopyrimidinones, and pyrrolopyrimidinones as ubiquitin-specific protease 7 inhibitors

The disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where R 1 , R 2 , R 3 , R 4 , R 5 , R 5′ , X 1 , X 2 , X 3 , n, and m are described herein.

Thienopyrimidinones as ubiquitin-specific protease 7 inhibitors

The disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where R1, R2, R3, R5, R5′, X1, X2, n, and m are described herein.

Chain grate-tandem type rotary kiln direct reduction technology for refractory low-grade micro-fine iron ore

A provided chain grate-tandem type rotary kiln direct reduction technology for refractory low-grade micro-fine iron ore mainly comprises the following technological steps: (1) grinding selection and pelletizing, namely performing wet grinding and pelletizing after crude concentrate powder and bentonite are mixed, so as to obtain pellet ore; (2) drying and pre-consolidating by using a chain grate, namely adding pellet ore into the chain grate to perform drying and preheating and finishing pre-consolidating; (3) roasting in an oxidizing rotary kiln, namely sending pellet ore into the oxidizing rotary kiln to perform further oxidation; (4) sending oxidized pellet ore into an annular cooler to cool; (5) roasting in a reducing rotary kiln, namely mixing oxidized pellet ore and additionally added coal powder, and adding the mixture into the reducing rotary kiln to perform reducing roasting; (6) adding metalized pellets into a residual-heat recovery apparatus to perform residual-heat recovery ...

Drilling string style magnetic fishing tool

The utility model discloses a drilling string style magnetic fishing tool, including the magnetism drilling string, magnetism drilling string inner chamber link up and is provided with mud circulation canal, is provided with from bottom to top's auger delivery passageway on the magnetism drilling string outer wall, and magnetism drilling string lower extreme is the link, and the upper end is provided with salvages the thing and keep the recess, salvages the thing and keeps the recess and be arranged in the auger delivery passageway and be used for keeping the salvage thing of carrying through the auger delivery passageway. The utility model discloses under the horizontal drilling condition, can stir the junk, load the junk through gluing magnetism junk and collection, reach and satisfy the trip -out condition.

Intelligent oscillation mixer

The utility model provides an intelligent oscillation mixer. The intelligent oscillation mixer comprises a base, a cover plate, an oscillation mechanism, a test tube adapter and a knuckle bearing, wherein the base is provided with a power switch; the cover plate is arranged on the base; the oscillating mechanism is composed of a motor, a cam installed on a rotating shaft of the motor and an oscillating disc. A circular groove matched with the cam is formed in the bottom of the swing disc, and a test tube adapter is mounted at the top of the swing disc; the outer ring of the joint bearing is fixed on the cover plate, and the inner ring of the joint bearing is connected to the swing disc corresponding to the middle part of the test tube adapter; and the oscillating mechanism controls the test tube adapter to oscillate through the oscillating disc. According to the utility model, the cam is driven by the motor to drive the swinging disc and the test tube adapter to periodically rotate andswing ...

Pyrrolo and pyrazolopyrimidines as ubiquitin-specific protease 7 inhibitors

The invention relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: R6 O R5' R5 R1 (R 3)m / N )-n I_ R4 il 0 (I) where m, n, X1, X2 , Ri-R, R5 , and R6 are described herein.

Method for efficiently deironing coal ash

The invention provides a method for efficiently deironing coal ash. Fine powder of raw coal ash is sequentially subjected to reduction, magnetic separation and hydrochloric acid leaching treatment, thereby finally obtaining the coal ash with the Fe2O3 content less than 0.02%. The method has the beneficial effects that the technology operation is simple, and the deironing efficiency is high, so that the Fe2O3 content in the coal ash is reduced to be lower than 0.02%; the calcium impurity also can be removed; moreover, a molecular sieve prepared by utilizing the coal ash after deironing by the method is high in quality, and the Fe2O3 content is less than the commercial value; not only can a duct of the molecular sieve be prevented from being blocked by a ferrum ion, but also the adsorption-desorption circulation service life can be prolonged. In addition, with the method, iron powder can be recycled in the magnetic separation process for iron smelting.

High salt waste water recycling device

The utility model provides a high salt waste water recycling device. Including the extraction jar, it includes first export, second export and controls first export respectively and the first valve and second valve of second export, jar, its and first exit linkage are retrieved mutually to the mother liquor, the jar is retrieved to extract phase, and it includes first entry and third export, firstentry and second exit linkage, heating device, it sets up the below of retrieving the jar in extract phase, condensation recovery device, its setting exports at the third, extract storage jar, its setting is at condensation recovery device's return line's output. Utilizing this device in getting rid of high salt waste water in remaining organic matter, realizing the used repeatedly of mother liquor and extractant, reduction in production cost avoids the emergence of secondary pollution phenomenon.

Gantry type automatic moxibustion instrument adopting sparrow-pecking moxibustion method

A gantry type automatic moxibustion instrument adopting a sparrow-pecking moxibustion method is a physical therapy device which is arranged in a gantry structure and adopts a sparrow-pecking method to conduct automatic moxibustion on health care acupuncture points, and main functional components of the device comprise a gantry frame mechanism, a diagnosis and treatment bed lifting mechanism, a position adjusting mechanism, an automatic sparrow-pecking mechanism and an automatic moxa feeding cylinder. The automatic sparrow-pecking moxibustion device has the advantages that automatic sparrow-pecking moxibustion can be implemented by simulating actions of arms and wrists of moxibustion operators, and requirements on the moxibustion operators are low; (2) a scanning camera is arranged, so that the body shape of a person subjected to moxibustion can be measured in the moxibustion preparation stage, and the moxibustion position can be automatically determined; an infrared temperature sensor and ...

DNA polymerase IIIC inhibitors and use thereof

The present invention relates to compounds and methods useful for inhibiting the DNA polymerase IIIC enzyme. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of Gram-positive bacterial infections.

Multiple-input multiple-output method and device

The invention discloses a multiple-input multiple-output method and a device. The method comprises the steps of: respectively generating a wave beam figuration weight corresponding to each user, respectively generating a reference wave beam figuration weight corresponding to each auxiliary scheduling user according a predetermined regulation, wherein the reference wave beam figuration weight is vertical to a signal space of a main scheduling user and the figuration gain is maximum, determining a channel quality indication corresponding to the auxiliary scheduling user according to the reference wave beam figuration weight corresponding to each auxiliary scheduling user, determining once transmission throughput of the auxiliary scheduling user according to the determined channel quality indication, choosing a reference auxiliary scheduling user to perform second order space division multiplexing with the main scheduling user from the auxiliary scheduling users, and in the event of meeting ...

Method for etching wafer chamfer by plasma and plasma etching equipment

The invention relates to the technical field of plasma etching, in particular to a method for etching a wafer chamfer through plasma and plasma etching equipment. Comprises: providing a silicon carbide wafer; forming a chamfer area and a mask area on the surface of the silicon carbide wafer; placing the silicon carbide wafer after the chamfering area and the mask area are formed in plasma equipment, performing plasma etching on the silicon carbide wafer, and forming a chamfer in the chamfering area of the silicon carbide wafer; and taking out the etched silicon carbide wafer, and removing the mask on the surface of the silicon carbide wafer. The silicon carbide wafer is placed in the etching environment of the plasma, the pressure of the etching environment, the flow of the reaction gas, the radio frequency and the radio frequency power are controlled, so that the reaction gas is converted into the plasma, and the plasma has the characteristics of high energy, high particle rate and high ...

Glass-based ion exchange optical waveguide chip integrated with magneto-optical function

The invention discloses a glass-based ion exchange optical waveguide chip integrated with a magneto-optical function. On the surface of glass, a region needing the magneto-optical function is provided with a ferromagnetic metal nanoparticle-doped region; by an ion exchange method, a strip-shaped ion diffusion region is formed in the glass, and a strip-shaped ion diffusion region with the magneto-optical function is formed in the ferromagnetic metal nanoparticle-doped region; the refractive index of the strip-shaped ion diffusion region is higher than that of the glass; the refractive index of the strip-shaped ion diffusion region with the magneto-optical function is higher than that of the ferromagnetic metal nanoparticle-doped region; the strip-shaped ion diffusion region and the strip-shaped ion diffusion region with the magneto-optical function together form a core part of a strip-shaped optical waveguide. According to the technical scheme, a magneto-optic waveguide is manufactured in ...

Method for directly reducing nonferrous smelting slag through oxygenation

The invention provides a method for directly reducing nonferrous smelting slag through oxygenation. The method comprises the following processing steps: step 1, adequately mixing nonferrous smelting slag, coal and oxygen producer according to the proportion of 1:(0.10-0.25):(0.15-0.30) until the materials are uniform mixed; step 2, sending the materials after uniformly mixing in the step 1 into a reducing device, roasting for 30-60min under the condition that the temperature is 1050-1200 DEG C to obtain a metallic mixture material; step 3: after cooling the material obtained in the step 2, crushing and grinding the material until 200 meshes of particles take up greater than 80%, and performing magnetic separation to obtain metallic iron powder. By adding oxygen producer in the nonferrous smelting slag, the reducing time of the nonferrous smelting slag is shortened to 30-60min from 60-120min, so that the productivity is improved, and meanwhile the reducing temperature is reduced to 1050- ...

GaAs integrated optical chip based on deep etching waveguide for optical fiber gyroscope

The invention relates to a GaAs integrated optical chip based on deep etching waveguide for an optical fiber gyroscope. Light is input through a mono-mode waveguide and is connected into the input end of a 3dB coupler through an input waveguide of the 3dB coupler; the output end of the 3dB coupler is divided into two paths, wherein one path is connected with a left phase modulator through a left output waveguide and a left S-shaped curved waveguide of the 3dB coupler, and the other path is connected with a right phase modulator through a right output waveguide and a right S-shaped waved waveguide of the 3dB coupler. A deep etching waveguide structure means that both sides of an upper limit layer and a core layer of a waveguide are all etched, and both sides of the connection part between the upper limit layer and the core layer are partially etched. The deep etching waveguide structure can enhance the limitation of the waveguide to light so as to improve the modulation efficiency of the ...

A device that is used for automatic gas -liquid separation under high depressurized environment of chlorine dioxide generator

The utility model discloses a device that is used for automatic gas -liquid separation under high depressurized environment of chlorine dioxide generator, including casing, gas -liquid autosegregation system and raffinate discharge system, gas -liquid autosegregation system includes the import of gas -liquid mixture thing, interior intubate, gas outlet, separator box, collection liquid case, float, trace, sealed awl and drain pipe, the entry linkage on gas -liquid mixture thing and separator box upper portion, separator box upper portion are equipped with the gas outlet, separator box and collection liquid case intercommunication, and the float passes through the sealed awl of trace control to be connected with the drain pipe mouth, and the trace fulcrum is fixed in and seals on the support, sealed support is fixed in an album liquid roof portion, and collection liquid bottom of the case portion is equipped with drain, blowoff valve, raffinate discharge system includes raffinate valve, ...

Tunable light filter device based on winding micro disc

The invention discloses a tunable optical filter based on a winding micro disc structure. The invented device comprises a partially winding micro disc resonant cavity and an optical input or output straight waveguide connected to the micro disc resonant cavity notch. The optical transmission straight waveguides are disposed respectively at the two sides of the micro disc resonant cavity bottom, and the other ends of the two optical transmission straight waveguides are connected to two waveguide reflection mirrors which are connected with each other by an orienting coupling structure or an MMI coupling structure. An electrode modulating area is disposed on the optical transmission straight waveguide or on the micro disc resonant cavity. The winding micro disc resonant cavity and the triangular waveguide mirror plane are combined organically with each other to implement wavelength quick selection. Devices such as a wave filter, an optical switch capable of selecting wavelength, a laser, a ...

Fluidized bed wrapping device for viscous particles

The invention provides the equipment using fluid bed to pack gummy grains. Roots fan (1) connects the buffering tank (2) through carbon steel wires; the outlet of the buffering tank connects the inlet of the dryer (4); the outlet of the dryer links to the air adjusting valve (5) and the inlet of the rotary flowmeter (6); the outlet of the flowmeter connects the bottom inlet of the pre-spreader (7) of the fluid bed; the spreader has multi-hole air distributing board (8); the upper part of pre-spreader (7) connects the glass fluid bed (11); the upper inlet of the glass fluid bed links to the cloth duster; the column form magnetic wires are equipped outside the fluid bed (11); the multi-hole air distributing board (8) is a compound air distributing board, which comprises 3-5 layer 200 eyes stainless steel web and a layer multi-hole stainless steel board tapping with the tapping ratio of 1-6%. The air distribution is well-proportioned and the distributing board does not produce micro-jet. The ...

Gas-liquid pressure cylinder

The invention discloses a gas-liquid pressure cylinder. The gas-liquid pressure cylinder is not provided with an oil storage cavity and is simple and compact in structure, convenient to maintain, high in efficiency, and saves energy. An oil inlet is formed in a liquid cylinder body and communicated with an oil storage tank of a braking system through a one-way valve. When the pressure cylinder does not have pressure air, the one-way valve is opened, and the oil storage tank is communicated with the pressure cylinder. After the pressure cylinder is filled with compressed air, due to the pressure action, the one-way valve is closed, and the passage between the oil storage tank and the pressure cylinder is cut off. The gas-liquid pressure cylinder can realize automatic oil supplement, lowers the labor intensity, and is low in maintenance cost. As a hydraulic sensor is arranged in the liquid cylinder body, the gas-liquid pressure cylinder has a real-time pressure monitoring function, can quickly ...

QUINAZOLINONES AND AZAQUINAZOLINONES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS

The present disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: 2. The compound of claim 1 , wherein Xis C.3. The compound of claim 1 , wherein Ris —OH.4. The compound of claim 1 , wherein Ris (C-C) alkyl or (C-C) aryl claim 1 , wherein the alkyl and aryl are optionally substituted with one or more R.5. The compound of claim 1 , wherein Ris H.6. The compound of claim 1 , wherein R is H.7. The compound of claim 1 , wherein is Yis Nor CRand Ris H.8. The compound of claim 1 , wherein Yis N or CRand Ris H claim 1 , (C-C) alkyl claim 1 , (C-C) alkoxy claim 1 , —NH claim 1 , —NHC(O)(C-C) alkyl claim 1 , or (C-C) aryl claim 1 , wherein the alkyl claim 1 , and aryl are optionally substituted with one or more R.9. The compound of claim 1 , wherein Yis N or CRand Ris H claim 1 , (C-C) alkyl claim 1 , (C-C) aryl claim 1 , or O-aryl claim 1 , wherein the alkyl and aryl are optionally substituted with one or more R.10. The compound of claim 1 , wherein n is 1.1213-. (canceled)15. (canceled)17. (canceled)20. The compound of selected from the group consisting of:3-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)methyl)-7-methoxyquinazolin-4(3H)-one;3-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)methyl)-8-methylquinazolin-4(3H)-one;7-amino-3-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)methyl)quinazolin-4(3H)-one;N-(3-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)methyl)-4-oxo-3,4-dihydroquinazolin-7-yl)acetamide;(R)-3-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)methyl)-7-methoxyquinazolin-4(3H)-one;(R)-3-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)methyl)-8-methylquinazolin-4(3H)-one;3-((1-(1-benzylindoline-5-carbonyl)-4-hydroxypiperidin-4-yl)methyl)-7-methylquinazolin-4(3H)-one;3-(1-benzoyl-4-hydroxypiperidin-4-yl)methyl)-7- ...

Car solar energy skylight packaging structure

The utility model discloses a car solar energy skylight packaging structure. It including the car glass layer that is located car surface one side, be located the transparent protection layer of car internal surface one side and press from both sides the solar cell structural layer between car glass layer and transparent protection layer, bond through outer tie coat between car glass layer and the solar cell structural layer, bond through interior tie coat between solar cell structural layer and the transparent protection layer or direct bonding. After adopting foretell structure, not only having guaranteed good light transmissivity, having guaranteed the holistic aesthetic property in whole skylight, its structural design is safer moreover, has avoided the glass breakage to cause secondary damage's problem to the passenger, and simultaneously, the epoxy glue dripping layer of adoption or flexiplast protecting film be as transparent protection layer, adapts to sunroof's various surperficial ...

Coloured solar energy glass

The utility model relates to a coloured solar energy glass. Including solar cell, be provided with the photoelectric conversion layer among the solar cell, the face that solar cell accepted sunshine is for positive, and the another side is the back, solar cell's the back through the one deck have the colour, the coloured glued membrane layer bonding one deck transparent backplate glass of transparent, it has a plurality of light transmission groove to distribute on the photoelectric conversion layer, and every light transmission groove's width is 50 -500um to light transmission groove's the whole area accounts for the long -pending 10 -40% of whole photoelectric conversion aspect, makes coloured solar energy glass not only have certain light transmissivity, and still be that the back can both present even colour from glass's front no matter.

Network video playing method and terminal

The invention discloses a network video playing method and terminal. The network video playing method comprises the steps of monitoring data request information sent to a server side from a first kind video client side, capturing a data package sent to the video client side by the server side according to the address of the server side contained in the data request information, analyzing the captured data package, and pushing the data package to DMR equipment to be played if the fact that the data package includes video data or video feature codes is analyzed, wherein the first kind video client side does not support a DLNA protocol. The network video playing method and terminal can meet the demands of users for watching more network videos.

But remote control computer that teaching was used

The utility model provides a but remote control computer that teaching was used, belongs to teaching of computer equipment apparatus technical field, including unable adjustment base, telescopic cylinder, controller, remote controller, connection crossbeam, transmission rack, transmitting gear, display, and its characterized in that: the last top of unable adjustment base surface the place ahead edge fixedly connected with telescopic cylinder of right side department, the last top surface of telescopic cylinder left side fixedly connected with controller, it has the remote controller to locate the cartridge on the controller in the middle of the surface of top, the fixedly connected with of department connection crossbeam in the middle of the surface of top before the telescopic cylinder, connect the crossbeam right side top surface trailing edge fixedly connected with of department transmission rack, the fixedly connected with transmitting gear of department in the middle of the left side ...

Concentrated feed for cattle and sheep

The invention provides a concentrated feed for cattle and sheep. The concentrated feed is prepared from the following components in parts by weight: 30-50 parts of fermented protein powder, 20-30 parts of fiber powder, 20-30 parts of clay, 20-40 parts of honey, 3-5 parts of an amino acid additive and 4-6 parts of mineral powder, according to the method, the soybean meal is treated in a microbial fermentation mode to decompose antinutritional factors in the soybean meal and degrade protein into small peptides easy to absorb, and then the fermented soybean meal is crushed into the fermented protein powder, so that the fermented protein powder is used as a protein feed in the concentrated feed; the influence of simultaneous feeding of urease and concentrated feed on the feeding effect is avoided, and the situation of urea poisoning of cattle and sheep caused by excessive feeding of the concentrated feed can be prevented; the concentrated feed for the cattle and the sheep is prepared into a ...

Epitaxial formula of emboliaing of transfer arm arm that stretches out and draws back

The utility model belongs to the technical field of mechanical equipment, especially, relate to an epitaxial formula of emboliaing of transfer arm arm that stretches out and draws back, epitaxial formula of emboliaing of transfer arm arm that stretches out and draws back, including the transfer arm, cup joint the fixed arm outside this transfer arm, set up hydro -cylinder and hydro -cylinder round pin axle in the fixed arm, the flexible arm of hydro -cylinder is connected with the tip of transfer arm, and its characterized in that has set up the U -shaped picture peg at the tip of transfer arm, and the opening diameter of this U -shaped picture peg is greater than the diameter of hydro -cylinder round pin axle. The utility model discloses become U -shaped picture peg structure at the end design of transfer arm for pass the cylinder end round pin axle of hydro -cylinder, make the effective length of transfer arm in the fixed arm increase, improved the direction effect of the flexible arm ...

Gas fuel oxygen-carried hydrogen-produced and carbon dioxide separation method and device

Automatic film sticking instrument

The utility model discloses an automatic film sticking instrument. FILM APPLIANCE OUTLET, a lower clamping plate is fixedly arranged below the film outlet; the upper surface of the lower clamping plate is flush with the film outlet; an upper clamping plate is arranged above the pasting film outlet, the upper clamping plate is connected with an air cylinder and corresponds to the lower clamping plate, a cutter and a gear motor are arranged on one side of the lower clamping plate, the surface of the cutter is tightly attached to the edge of the upper clamping plate and the edge of the lower clamping plate, and the gear motor controls the cutter to rotate around a rotating shaft. The automatic film pasting instrument can accurately and quickly shear a pasted film finished product, avoids damage of hand tearing to a pasted film, and enables a tearing opening to be more attractive and tidy; besides mode switching, the film pasting process does not need manual operation completely, and the two ...

Thermoopic type variable optical attenuator and array type variable optical attentuator using this

A thermo optical type variable optical attenuator suitable for application in an array type variable optical attenuator that realizes low crosstalk between neighboring waveguides in the array is provided. A thermo optical type variable optical attenuator 100 using optical material having negative optical effect provides a multimode optical propagating part 3 disposed via a tapered part 2 and a tapered part 7 between single mode optical waveguides 1 and 8 . A thin-film heater 4 is disposed above the multimode optical propagating part 3 at an angle of inclination beta in relation to the direction of light propagation along a first optical waveguide 50 . Moreover, a second optical waveguide 9 optically coupled with a side face 3 S 1 of the multimode optical propagating part 3 is provided at an angle of inclination 2 beta in relation to the direction of light propagation along the first optical waveguide 50.

High-toughness weather-proof modified polypropylene material

This invention relates to a high-tenacity weather-resistance modified polypropylene material whose components (wt.%) are: copolymerized polypropylene (MFI>3) 40-50, rubber/plastics mother granule 40-50, anti-oxidant mother granule 2-5, photo stabilizer mother granule 2-6, and black mother granule 1-2, the above materials being proportionately and uniformly mixed, and they are prilled in double spiral-stem extruder under processing temp. of 200-240 deg.C. This invented modified polypropylene has superior tenacity, high strength, good photo- and heat-stability, and anti-cold and anti-corrosion properties. This product can be widely used in the automabile manufacturing industry and the household electric appliance trade.

DNA polymerase IIIC inhibitors and use thereof

The present invention relates to compounds and methods useful for inhibiting the DNA polymerase IIIC enzyme. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of Gram-positive bacterial infections.

Electro optic modulator based on horizontal narrow slit flat-plate and photon crystal linear defect wave-guide

Preparation technology of cattle and sheep feed

The invention discloses a preparation technology of cattle and sheep feed, and belongs to the technical field of feed. Comprising the following steps: S1, proportioning the following components in parts by weight: 900-1000 parts of sugarcane leaves; 16 to 20 parts of bone meal; 5-7 parts of corn flour; 40 to 48 parts of bagasse; 28 to 30 parts of urea; 4-5 parts of sodium bicarbonate; 2 to 2.5 parts of calcium bicarbonate; 8 to 10 parts of molasses; 1-2 parts of a composite preparation; 0.30 to 0.35 part of a microbial preparation; s2, the sugarcane leaves are kneaded, and then the sugarcane leaves are cut into pieces with the length of 3.5-4.5 cm; s3, drying the sugarcane slices treated in the step S2 by using a drying machine; s4, dissolving the compound preparation, the microbial preparation, the sodium bicarbonate, the calcium bicarbonate, the urea and the molasses in water, and uniformly spraying the solution on the sugarcane leaves; s5, crushing bagasse by using a crusher, and then ...

Improved channel catfish directional mating and spawning device

The utility model discloses an improved channel catfish directional mating and spawning device. The device comprises a water container (1), the device is characterized in that a permeable cushion layer (2) is arranged at the inner bottom of the water container; an inner cylinder (3) with two through ends is laid on the water-permeable cushion layer; the large end of the inner cylinder faces downwards; small end-up, a silk net (4) for holding roes is laid on the permeable cushion layer; a cover (5) for preventing the channel catfish from escaping is mounted at the small end of the upper part ofthe inner cylinder; the inner cylinder is connected with a water inlet pipe (6) for adjusting the water environment in the inner cylinder; wherein the water inlet pipe is communicated with a water source, a water outlet is formed in the bottom of the water container, a water level adjusting pipe (7) is additionally arranged on the water outlet, and water exceeding an inlet of the water level adjusting ...

Manufacturing method for super 13Cr tool joint

The invention discloses a manufacturing method for a super 13Cr tool joint. The manufacturing method comprises the following steps of manufacturing a blank; forging the blank; heating the forged blank until the temperature of the forged blank is 600-700 DEG C and performing stress relieving on the blank; performing quenching on the blank; and performing tempering on the blank. According to the technical scheme, the super 13Cr tool joint of which the mechanical property can reach 110ksi can be manufactured.

SPIRAL FIN HEAT EXCHANGER WITH A NEW FIXED MANNER

A spiral fin heat exchanger with a new fixed manner includes a bended fin tube comprising a inner tube on which fins are provided, and several fixing members are provided on the fin tube, the fixing member includes an upper bracket and a lower bracket, and the upper bracket comprises a cover plate and a vertical plate, the upper bracket is fixedly connected with the lower bracket, and the fins on the fin tube are caught between the cover plate and the lower bracket, a positioning groove is provided on the vertical plate, and the inner tube of the fin tube is caught in the positioning groove. The spiral fin heat exchanger can fix the fins and the inner tube of the fin tube simultaneously through the upper and lower brackets of the fixing member, thereby achieving the effect of dual fixation, such that the fin tube can be fixed more firmly and is not easy to loosen, which can in turn reduce the noise of spiral fin heat exchanger effectively. 1. A spiral fin heat exchanger with a new fixed manner including a bended fin tube comprising a inner tube on which fins are provided , it is characterized in that: several fixing members are provided on the fin tube , the fixing member includes an upper bracket and a lower bracket , the upper bracket comprises a cover plate and a vertical plate , the upper bracket is fixedly connected with the lower bracket , and the fins on the fin tube are caught between the cover plate and the lower bracket , a positioning groove is provided on the vertical plate , and the inner tube of the fin tube is caught in the positioning groove.2. The spiral fin heat exchanger with a new fixed manner according to claim 1 , characterized in that: the fin tube is repeatedly bended claim 1 , and lengths of the two adjacent bends of the fin tube are different.3. The spiral fin heat exchanger with a new fixed manner according to claim 1 , characterized in that: the upper bracket is fixedly connected with the lower bracket through a side bracket. This ...

ASSISTANT SYSTEM FOR THE TOUR GUIDE

The invention relates to an assistant system for the tour guide, comprising a tour guide roll-call device, a plurality of labels for tourists and an intelligent mobile phone. The tourist guide roll-call device communicates with the labels tourists wearing via wireless network; the intelligent mobile phone communicates with the roll-call device via Bluetooth. After the tour guide roll-call device is respectively connected to the labels tourists wearing and the intelligent mobile phone, the intelligent mobile phone sends roll-call signal to the labels tourists wearing via the tour guide roll-call device. In setting area, the labels tourists wearing receive the roll-call signal and send feedback signal. The tour guide roll-call device receives the signal and sends it to the intelligent mobile phone. The intelligent mobile phone reads the signal to judge whether tourists are in place, and displays the roll-call result information on the screen. 1. An assistant system for the tour guide , comprising a tour guide roll-call device , a plurality of labels for tourists and an intelligent mobile phone; wherein , the tour guide roll-call device is connected to the labels tourists wearing by wireless communication; the intelligent mobile phone is connected to the tour guide roll-call device by Bluetooth communication;after the tour guide roll-call device has respectively connected with the labels tourists wearing and the intelligent mobile phone, the intelligent mobile phone sends roll-call signal to the labels tourists wearing through the tour guide roll-call device; in the special area, the labels tourists wearing receive the roll-call signal and send feedback signal; then the tour guide roll-call device receives the signal and sends it to the intelligent mobile phone; the intelligent mobile phone judges whether tourists are in place or not, and displays the roll-call result information on the screen.2. The assistant system for the tour guide according to claim 1 , wherein ...

Hydroxamic acid derivative, method for producing same and use thereof

The present disclosure is related to the field of enzyme inhibitors, and in particular to a hydroxamic acid derivative, a method for producing the same and use thereof. The hydroxamic acid group of the hydroxamic acid derivative can be chelated with zinc ions in the LpxC active area, and the derivative has a hydrophobic side chain which can bind to hydrophic channels in the enzyme LpxC. These guarantee that the hydroxamic acid derivative has good bactericidal activity against Gram-negative bacteria and low toxicity. The present disclosure also provides a method for producing the hydroxamic acid derivative, which requires a shorter reaction time and can provide the derivative with a high yield.

PYRROLOTRIAZINONES AND IMIDAZOTRIAZINONES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS

The invention relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: 147-. (canceled)49. The method according to claim 48 , wherein Ris H.50. The method according to claim 49 , wherein Ris H.51. The method according to claim 50 , wherein Ris (C-C) alkyl claim 50 , wherein the alkyl is optionally substituted with one more R.52. The method according to claim 51 , wherein Ris (C-C) alkyl claim 51 , wherein the alkyl is substituted with one more R.53. The method according to claim 52 , wherein Ris (C-C) alkyl claim 52 , wherein the alkyl is substituted with —(C-C)-alkylene-aryl.54. The method according to claim 52 , wherein Ris (C-C) alkyl claim 52 , wherein the alkyl is substituted with —(C-C)-alkylene-heteroaryl.55. The method according to claim 48 , wherein the compound is (R)-3-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)methyl)pyrrolo[2 claim 48 ,1-f][1 claim 48 ,2 claim 48 ,4]triazin-4(3H)-one claim 48 , or a pharmaceutically acceptable salt thereof.56. The method according to claim 48 , wherein the compound is 3-((1-(3-(1H-pyrrol-1-yl)butanoyl)-4-hydroxypiperidin-4-yl)methyl)pyrrolo[2 claim 48 ,1-f][1 claim 48 ,2 claim 48 ,4]triazin-4(3H)-one claim 48 , or a pharmaceutically acceptable salt thereof.57. The method according to claim 48 , wherein the disease or disorder associated with modulation of USP7 is cancer and metastasis claim 48 , neurodegenerative diseases claim 48 , immunological disorders claim 48 , diabetes claim 48 , bone and joint diseases claim 48 , osteoporosis claim 48 , arthritis inflammatory disorders claim 48 , cardiovascular diseases claim 48 , ischemic diseases claim 48 , viral infections and diseases claim 48 , viral infectivity and/or latency claim 48 , and bacterial infections and diseases.59. A method of ...

Method, device and computer-readable storage medium for guiding symbolic execution

The present disclosure provides a method, apparatus, device and computer-readable storage medium for guiding symbolic execution. According to embodiments of the present disclosure, it is possible to determine the specific code region of the program, and obtain the program loop output of the program corresponding to the specific code region of the program by using the program inverse analysis method, so that it is possible to obtain the program loop input of the program corresponding to the specific code region by using the program loop predictor according to the program loop output of the program. In this way, the obtained program loop input of the program corresponding to the specific code region may be used to guide the symbolic execution to filter out impossible execution paths and jump out of the program code and reach the specific code region, thereby improving the reliability of the symbolic execution.

Method of manufacturing superior 13cr thickened drillrod

A method for manufacturing a superior 13Cr thickened drillrod comprises the following steps: firstly, thickening the ends of a steel tube with a composition so as to obtain a drillrod with thickened ends, the composition in percentage by weight being: C: 0.01-0.05%, Si≦0.5%, Mn: 0.2-1.0%, Cr: 12-14%, Mo: 1-3%, Ni: 4-6%, and a balance of Fe and inevitable impurities; after heating the tube as a whole to 950-1000° C., air cooling same and tempering same at 600-650° C.; and machining the two thickened ends respectively into an externally threaded drillrod coupler and an internally threaded drillrod coupler; wherein the tube end thickening is an external thickening, including three rounds of heating and three rounds of thickening, with at least one pass of deformation for each round, and the heating temperature being 1150-1200° C. for each round; and the upsetting pressure for the first round of external thickening is 180-220 bars, the upsetting pressure for the second round of external thickening is 180-220 bars, and the upsetting pressure for the third round of external thickening is 140-180 bars. The drillrod according to the present invention can be used not only as a drillrod but also as an oil tube, fulfilling requirements of the exploration operation of a CO 2 -containing gas field of compact sandstone with a high yield.

METHOD FOR MANUFACTURING SUPERIOR 13CR TOOL COUPLER

The present invention discloses a method for manufacturing a superior 13Cr tool coupler, which method comprises the following steps: manufacturing a blank; 2. The method of claim 1 , wherein the 13Cr tool coupler consists essentially of 0.01-0.05 wt % carbon claim 1 , ≦0.5 wt % silicon claim 1 , 0.2-1.0 wt % manganese claim 1 , 12-14 wt % chromium claim 1 , 1-3 wt % molybdenum claim 1 , 4-6 wt % nickel claim 1 , and a balance of iron (Fe) and other impurities.3. The method of claim 1 , wherein the manufactured blank is forged at a temperature ranging from 1150-1200° C.4. The method of claim 1 , wherein the annealed blank is quenched at a temperature ranging from 950-1000° C.5. The method of claim 1 , wherein the annealed blank is quenched with oil.6. The method of claim 1 , wherein the quenched blank is tempered at a temperature ranging from 600-650° C.7. The method of claim 1 , further comprising rough machining the annealed blank before quenching the annealed blank. The present invention relates to a method for manufacturing a coupler, and in particular a method for manufacturing a high alloy coupler.Drillrods for use in oil and natural gas exploration are manufactured according to the API SPEC 5DP standards. The structure thereof has an externally threaded drillrod coupler and an internally threaded drillrod coupler which are respectively frictionally butt-welded at the two ends of the drillrod tube body. Drillrods in compliance with the API SPEC 5DP standards are of a low alloy steel material.With the development of the oil industry, the conditions in which drillrods operate become more and more severe, drillrods of the low alloy steel material as per the API SPEC 5DP standards now fail to fulfill the increasingly harsh requirements of well drilling operation, and there exists an urgent need for a high alloy drillrod. To this end, aluminum alloy drillrods and titanium alloy drillrods appeared on the market. The aluminum alloy drillrods are manufactured as per ...

QUINAZOLINONES AND AZAQUINAZOLINONES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS

The present disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: 2. The compound of claim 1 , wherein:{'sub': 2', '1', '6', '6', '14', '8, 'Ris (C-C) alkyl, or (C-C) aryl, wherein the alkyl or aryl are optionally substituted with one to two R;'}{'sub': 8', '0', '4', '6', '14', '9', '8', '3', '8', '9, 'each Ris independently halogen or (C-C)-alkylene-(C-C) aryl, wherein the aryl is optionally substituted with one to three R; or two Rtogether when on adjacent atoms form a (C-C) cycloalkyl optionally substituted with one to three R; and'}{'sub': 9', '0', '3', '6', '14, 'each Ris —(C-C)-alkylene-(C-C) aryl.'}3. The compound of claim 2 , wherein Ris (C-C) alkyl substituted with one R; and Ris —(C-C)-alkylene-(C-C) aryl.4. The compound of claim 2 , wherein Ris (C-C) aryl.5. The compound of claim 4 , wherein two Rtogether when on adjacent atoms form a (C-C) cycloalkyl optionally substituted with one to three R.6. The compound of claim 5 , wherein the (C-C)cycloalkyl formed by two Rtogether on adjacent atoms is substituted with one Rand R—is (C-C)-alkylene-(C-C) aryl.7. The compound of claim 2 , wherein{'sub': '6', 'Ris H;'}{'sub': 1', '6', '6', '6', '14, 'is (C-C) alkyl, C-aryl, or —O—C-aryl, wherein the alkyl or aryl are optionally substituted with one to three R; and'}{'sub': 14', '1', '6', '1', '6', '1', '6', '1', '6', '2', '1', '6', '1', '6, 'each Ris independently (C-C) alkyl, (C-C) alkoxy, (C-C) haloalkyl, (C-C) haloalkoxy, halogen, CN, —OH, —NH, (C-C) alkylamino, or di(C-C) alkylamino.'}8. The compound of claim 7 , wherein Ris halogen.9. The compound of claim 8 , wherein Ris C-aryl.10. The compound of claim 8 , wherein Ris —O—C-aryl.11. The compound of claim 2 , wherein{'sub': 6', '1', '6', '1', '6', '2', '1', '6', '6', '14 ...

Quinazolinones and azaquinazolinones as ubiquitin-specific protease 7 inhibitors

where R1, R2, R3, R4, R4′, X1, Y1, Y2, Y3, Y4, n, and m are described herein.

QUINAZOLINONES AND AZAQUINAZOLINONES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS

The present disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: 2. The compound of claim 1 , wherein n is 1.3. The compound of claim 1 , wherein m is 0.4. The compound of claim 3 , wherein n is 1.5. The compound of claim 4 , wherein Ris 3-butyl.6. The compound of claim 5 , wherein Ris —(C)-alkylene-(C) aryl.7. The compound of claim 6 , wherein Ris —(C)-alkylene-(C) aryl unsubstituted with R.8. The compound of claim 7 , wherein Ris H.9. The compound of claim 7 , wherein Ris (C-C) alkoxy claim 7 , (C-C) haloalkyl claim 7 , (C-C) haloalkoxy claim 7 , halogen other than Cl claim 7 , CN claim 7 , NO claim 7 , or —NH.10. The compound of claim 7 , wherein{'sub': 6', '1', '6', '1', '6', '1', '6', '1', '6', '2', '2', '1', '6', '13, 'Ris (C-C) alkyl, (C-C) alkoxy, (C-C) haloalkyl, (C-C) haloalkoxy, halogen other than Cl, CN, NO, —NH, —NHC(O)(C-C) alkyl, wherein the alkyl is optionally substituted with one to three R;'}{'sub': 13', '1', '6', '1', '6', '1', '6', '1', '6', '2', '1', '6', 'q', '1', '6', '1', '6', '1', '6', '15, 'each Ris independently (C-C) alkyl, (C-C) alkoxy, (C-C) haloalkyl, (C-C) haloalkoxy, halogen, CN, —OH, —NH, —C(O)(C-C) alkyl, —S(O)(C-C) alkyl, (C-C) alkylamino, di(C-C) alkylamino, 3- to 7-membered heterocycloalkyl comprising 1 to 3 heteroatoms selected from O, N, and S, wherein in the alkyl or heterocycloalkyl are optionally substituted with one to three R; and'}{'sub': 15', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '2', '1', '6', '1', '6, 'each Ris independently (C-C) alkyl, (C-C) alkoxy, (C-C) haloalkyl, (C-C) haloalkoxy, halogen, —C(O)(C-C) alkyl, —NH, (C-C) alkylamino, di(C-C) alkylamino, —OH, or CN.'}11. The compound of claim 7 , wherein Ris —NHC(O)(C-C) alkyl.12. The compound of claim 11 , wherein ...

Quinazolinones and azaquinazolinones as ubiquitin-specific protease 7 inhibitors

The present disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where R 1 , R 2 , R 3 , R 4 , R 4′ , X 1 , Y 1 , Y 2 , Y 3 , Y 4 , n, and m are described herein.

QUINAZOLINONES AND AZAQUINAZOLINONES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS

The present disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: 3. The compound of claim 2 , wherein{'sub': 2', '1', '6', '6', '14', '8, 'Ris (C-C) alkyl, or (C-C) aryl, wherein the alkyl or aryl are optionally substituted with one to three R;'}{'sub': 8', '1', '6', '1', '6', '1', '6', '1', '6', '1', '3', '1', '6', '0', '4', '6', '0', '4', '5', '6', '0', '4', '6', '0', '4', '5', '6', '21', '21', '21', '22', 'q', '21', 'q', '21', '22', '21', 'q', '22', '0', '3', '21', '22', '21', '22', '21', '22', '21', '21', '22', '21', '9', '8', '3', '8', '9, 'each Ris independently (C-C) alkyl, (C-C) alkoxy, (C-C) haloalkyl, (C-C) haloalkoxy, halogen, CN, —(C-C)-alkylene-O—(C-C) alkyl, —(C-C)-alkylene-(C) aryl —(C-C)-alkylene-5- or 6-membered heteroaryl comprising 1 to 3 heteroatoms selected from O, N, and S, (C-C) cycloalkyl,5- to 6-membered heterocycloalkyl comprising 1 to 3 heteroatoms selected from O, N, and S, —(C-C)-alkylene-O—(C) aryl, —(C-C)-alkylene-O-5- or 6-membered heteroaryl comprising 1 to 3 heteroatoms selected from O, N, and S, —O—(C-C) cycloalkyl, —S-5- or 6-membered heteroaryl comprising 1 to 3 heteroatoms selected from O, N, and S, —C(O)R, —CO(O)R, —C(O)NRR, —S(O)R, —S(O)NRR, —NRS(O)R, —(C-C)-alkylene-NRR, —NRC(O)R, —NRC(O)C(O)R, —NRC(O)NRR, or —OR, wherein the alkyl, alkylene, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl are optionally substituted with one to three R; or two Rtogether when on adjacent atoms form a (C-C) cycloalkyl optionally substituted with one to three R;'}{'sub': 9', '1', '6', '1', '6', '1', '6', '1', '6', '3', '8', '0', '3', '6', '0', '3', '2', '6', '19, 'each Ris independently (C-C) alkyl, (C-C) alkoxy, (C-C) haloalkyl, (C-C) haloalkoxy, halogen, (C-C) cycloalkyl, 5- to 6-membered ...

QUINAZOLINONES AND AZAQUINAZOLINONES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS

The present disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: 3. The compound of claim 2 , wherein{'sub': 2', '1', '6', '6', '14', '8, 'Ris (C-C) alkyl or (C-C) aryl, wherein the alkyl or aryl are optionally substituted with one to three R;'}{'sub': 8', '1', '6', '1', '6', '1', '6', '1', '6', '1', '3', '1', '6', '0', '4', '6', '0', '4', '5', '6', '0', '4', '6', '0', '4', '5', '6', '21', '21', '21', '22', 'q', '21', 'q', '21', '22', '21', 'q', '22', '0', '3', '21', '22', '21', '22', '21', '22', '21', '21', '22', '21', '9', '8', '3', '8', '9, 'each Ris independently (C-C) alkyl, (C-C) alkoxy, (C-C) haloalkyl, (C-C) haloalkoxy, halogen, CN, —(C-C)-alkylene-O—(C-C) alkyl, —(C-C)-alkylene-(C) aryl —(C-C)-alkylene-5- or 6-membered heteroaryl comprising 1 to 3 heteroatoms selected from O, N, and S, (C-C) cycloalkyl,5- to 6-membered heterocycloalkyl comprising 1 to 3 heteroatoms selected from O, N, and S, —(C-C)-alkylene-O—(C) aryl, —(C-C)-alkylene-O-5- or 6-membered heteroaryl comprising 1 to 3 heteroatoms selected from O, N, and S, —O—(C-C) cycloalkyl, —S-5- or 6-membered heteroaryl comprising 1 to 3 heteroatoms selected from O, N, and S, —C(O)R, —CO(O)R, —C(O)NRR, —S(O)R, —S(O)NRR, —NRS(O)R, —(C-C)-alkylene-NRR, —NRC(O)R, —NRC(O)C(O)R, —NRC(O)NRR, or —OR, wherein the alkyl, alkylene, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl are optionally substituted with one to three R; or two Rtogether when on adjacent atoms form a (C-C) cycloalkyl optionally substituted with one to three R;'}{'sub': 9', '1', '6', '1', '6', '1', '6', '1', '6', '3', '8', '0', '3', '6', '0', '3', '2', '6', '19, 'each Ris independently (C-C) alkyl, (C-C) alkoxy, (C-C) haloalkyl, (C-C) haloalkoxy, halogen, (C-C) cycloalkyl, 5- to 6-membered ...

PURINONES AS UBIQUITIN-SPECIFIC PROTEASE 1 INHIBITORS

The application relates to inhibitors of USP1 useful in the treatment of cancers, and other USP1 associated diseases and disorders, having the Formula: 141-. (canceled)43. The compound of claim 42 , wherein Xis CR.44. The compound of claim 42 , wherein Ris selected from the group consisting of H claim 42 , (C-C) alkyl claim 42 , (C-C) alkenyl claim 42 , (C-C) alkynyl claim 42 , (C-C) haloalkyl claim 42 , (C-C) hydroxyalkyl claim 42 , or heterocycloalkyl claim 42 , wherein the alkyl claim 42 , alkenyl claim 42 , alkynyl claim 42 , and heterocycloalkyl are optionally substituted with one or more substituents selected from halogen —OR claim 42 , —C(O)R claim 42 , —NRR claim 42 , —NRC(O)R claim 42 , —C(O)NRR claim 42 , —NRC(O)NRR claim 42 , —NRS(O)R claim 42 , —S(O)NRR claim 42 , —NRS(O)NRR claim 42 , —S(O)R claim 42 , —P(O)RR claim 42 , and —Si((C-C) alkyl).45. The compound of claim 42 , where Ris H claim 42 , methyl claim 42 , —CHCHOH claim 42 , —CHCHNH claim 42 , —CH(CH)C(O)OH claim 42 , or piperidinyl optionally substituted with —C(O)R.46. The compound of claim 42 , where Ris H or methyl.47. The compound of claim 42 , wherein Ris (C-C) alkyl claim 42 , (C-C) alkoxy claim 42 , (C-C) haloalkyl claim 42 , (C-C) haloalkoxy claim 42 , (C-C) cycloalkyl claim 42 , halogen claim 42 , —NH claim 42 , or —C(O)(C-C) alkyl claim 42 , wherein the alkyl is optionally substituted with one to three substituents (C-C) alkoxy.48. The compound of claim 42 , wherein Ris heterocycloalkyl.49. The compound of claim 49 , wherein Ris pyrrolidinyl claim 49 , piperazinyl claim 49 , or piperidinyl.50. The compound of claim 42 , wherein Rand Xtogether with the atoms to which they are attached form a (C-C) aryl ring optionally substituted with one or more R.51. The compound of claim 42 , wherein Rand Xon adjacent atoms together with the atoms to which they are attached form a heteroaryl ring optionally substituted with one or more R.52. The compound of claim 42 , wherein Rand Xtogether with the ...

QUINAZOLINONES AND AZAQUINAZOLINONES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS

The present disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: 2. The method of claim 1 , wherein:{'sub': 2', '1', '6', '6', '14', '8, 'Ris (C-C) alkyl or (C-C) aryl, wherein the alkyl or aryl are optionally substituted with one to two R;'}{'sub': 8', '0', '4', '6', '14', '9', '8', '3', '8', '9, 'each Ris independently halogen or —(C-C)-alkylene-(C-C) aryl, wherein the aryl is optionally substituted with one to three R; or two Rtogether when on adjacent atoms form a (C-C) cycloalkyl optionally substituted with one to three R; and'}{'sub': 9', '0', '3', '6', '14, 'each Ris —(C-C)-alkylene-(C-C) aryl.'}3. The method of claim 2 , wherein Ris (C-C) alkyl substituted with one R; and Ris —(C-C)-alkylene-(C-C) aryl.4. The method of claim 2 , wherein Ris (C-C) aryl.5. The method of claim 4 , wherein two Rtogether when on adjacent atoms form a (C-C) cycloalkyl optionally substituted with one to three R.6. The method of claim 5 , wherein the (C-C)cycloalkyl formed by two Rtogether on adjacent atoms is substituted with one Rand Ris —(C-C)-alkylene-(C-C) aryl.7. The method of claim 2 , wherein{'sub': '6', 'Ris H;'}{'sub': 7', '1', '6', '6', '6', '14, 'Ris (C-C) alkyl, C-aryl, or —O—C-aryl, wherein the alkyl or aryl are optionally substituted with one to three R; and'}{'sub': 14', '1', '6', '1', '6', '1', '6', '1', '6', '2', '1', '6', '1', '6, 'each Ris independently (C-C) alkyl, (C-C) alkoxy, (C-C) haloalkyl, (C-C) haloalkoxy, halogen, CN, —OH, —NH, (C-C) alkylamino, or di(C-C) alkylamino.'}8. The method of claim 7 , wherein Ris halogen.9. The method of claim 8 , wherein Ris C-aryl.10. The method of claim 8 , wherein Ris —O—C-aryl.11. The method of claim 2 , wherein{'sub': 6', '1', '6', '1', '6', '2', '1', '6', '6', '14', '13, 'Ris (C ...

PURINONES AS UBIQUITIN-SPECIFIC PROTEASE 1 INHIBITORS

The application relates to inhibitors of USP1 useful in the treatment of cancers, and other USP1 associated diseases and disorders, having the Formula: 241-. (canceled)42. The compound of claim 1 , wherein:{'sub': 1', '6, 'Xis CR;'}{'sub': '2', 'Xis N;'}{'sub': 3', '8, 'Xis CR; and'}{'sub': '4', 'Xis N.'}43. The compound of claim 42 , wherein Ris H claim 42 , (C-C) hydroxyalkyl claim 42 , heterocycloalkyl claim 42 , or (C-C) alkyl optionally substituted with one or two substituents selected from —COH claim 42 , —NH claim 42 , and —N((C-C) alkyl).4443. The compound of claim 42 , wherein Ris H or methyl.45. The compound of claim 44 , wherein Ris (C) aryl claim 44 , 5- or 6-membered heteroaryl claim 44 , (C-C) cycloalkyl claim 44 , or 5- or 6-membered heterocycloalkyl claim 44 , wherein the aryl claim 44 , heteroaryl claim 44 , cycloalkyl and heterocycloalkyl are substituted with one or more R.46. The compound of claim 45 , wherein Ris phenyl claim 45 , pyrazolyl claim 45 , pyridinyl claim 45 , pyridin-2-onyl claim 45 , pyrimidinyl claim 45 , cyclobutyl claim 45 , cyclohexyl claim 45 , piperidinyl claim 45 , piperidinonyl claim 45 , pyridinonyl claim 45 , or pyrrolinyl claim 45 , wherein each Ris substituted with one to three R.48. The compound of claim 47 , wherein Rand R are each independently H or (C-C) alkyl.49. The compound of claim 48 , wherein Ris H or Calkyl and Ris H or methyl.50. The compound of claim 48 , wherein Ris (C-C) alkyl claim 48 , (C-C) alkoxy claim 48 , (C-C) haloalkyl claim 48 , (C-C) haloalkoxy claim 48 , (C-C) cycloalkyl claim 48 , halogen claim 48 , —NH claim 48 , or —C(O)(C-C) alkyl claim 48 , wherein the alkyl is optionally substituted with one to three substituents (C-C) alkoxy.51. The compound of claim 48 , wherein Ris (C-C) alkyl claim 48 , halogen claim 48 , (C-C) haloalkyl claim 48 , (C-C) haloalkoxy claim 48 , or (C-C) alkoxy optionally substituted with (C-C) alkoxy.52. The compound of claim 50 , wherein Ris H.53. The compound of claim ...

PURINONES AS UBIQUITIN-SPECIFIC PROTEASE 1 INHIBITORS

The application relates to inhibitors of USP1 useful in the treatment of cancers, and other USP1 associated diseases and disorders, having the Formula: 2. The compound of claim 1 , wherein:{'sub': 1', '6, 'Xis CRor N;'}{'sub': 2', '7, 'Xis CRor N;'}{'sub': 3', '8, 'Xis CRor N;'}{'sub': 4', '9, 'Xis CRor N;'}{'sub': 1', '1', '6', '2', '6', '2', '6', '1', '6', '2', '6', '20', '20', '2', '20', '18', '19', '2', '21', '20', '21', '20', '21', '22', '20', 'r', '21', 'r', '20', '21', '20', 'r', '21', '22', 'r', '20', '20', '21', '1', '4', '3, 'Ris H, (C-C) alkyl, (C-C) alkenyl, (C-C) alkynyl, (C-C) haloalkyl, (C-C) hydroxyalkyl, or heterocycloalkyl, wherein the alkyl, alkenyl, alkynyl, and heterocycloalkyl are optionally substituted with one or more substituents selected from halogen, —OR, —C(O)R, —COR, —NRR, —NROC(O)R, —C(O)NRR, —NRC(O)NRR, —NRS(O)R, —S(O)NRR, —NRS(O)NRR, —S(O)R, —P(O)RR, and —Si((C-C) alkyl)'}{'sub': 2', '6', '14', '3', '8', '10, 'Ris (C-C) aryl, heteroaryl, (C-C) cycloalkyl, or heterocycloalkyl, wherein the aryl, heteroaryl, cycloalkyl, and heterocycloalkyl are substituted with one or more R;'}{'sub': 3', '1', '6', '1', '6', '1', '6', '1', '6', '2, 'Ris H, (C-C) alkyl, (C-C) haloalkyl, (C-C) hydroxyalkyl, (C-C) aminoalkyl, heterocycloalkyl, —C(O)OH, —C(O)NH, or CN;'}{'sub': 3′', '1', '6', '1', '6', '1', '6', '1', '6', '2, 'R is H, (C-C) alkyl, (C-C) haloalkyl, (C-C) hydroxyalkyl, (C-C) aminoalkyl, heterocycloalkyl, —C(O)OH, —C(O)NH, or CN; or'}{'sub': 3', '3′', '3', '7', '3', '3′, 'Rand R together with the carbon atom to which they are attached may form a (C-C) cycloalkyl ring; Rand R together with the carbon atom to which they are attached form a heterocycloalkyl ring;'}{'sub': 4', '1', '6', '2', '6', '2', '6', '1', '6', '1', '6', '1', '6', '3', '8', '2', '1', '4', '1', '4', '1', '4', '2', '1', '6', '1', '6', '3', '8', '2', '1', '4', '1', '4', '2, 'Ris (C-C) alkyl, (C-C) alkenyl, (C-C) alkynyl, (C-C) alkoxy, (C-C) haloalkyl, (C-C) haloalkoxy, (C-C) ...

QUINAZOLINONES AND AZAQUINAZOLINONES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS

The present disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: 221-. (canceled)22. A method of treating a disease or disorder associated with modulation of USP7 comprising claim 1 , administering to a patient in need thereof an effective amount of a compound of .23. The method of claim 22 , wherein the disease or disorder associated with modulation of USP7 is cancer and metastasis claim 22 , neurodegenerative diseases claim 22 , immunological disorders claim 22 , diabetes claim 22 , bone and joint diseases claim 22 , osteoporosis claim 22 , arthritis inflammatory disorders claim 22 , cardiovascular diseases claim 22 , ischemic diseases claim 22 , viral infections and diseases claim 22 , viral infectivity and/or latency claim 22 , and bacterial infections and diseases.24. A method of inhibiting USP7 comprising claim 1 , administering to a patient in need thereof an effective amount of a compound of .25. A method of treating cancer claim 1 , the method comprising administering claim 1 , to a patient in need thereof an effective amount of a compound of .26. The method of claim 25 , wherein the cancer is liposarcoma claim 25 , neuroblastoma claim 25 , glioblastoma claim 25 , bladder cancer claim 25 , adrenocortical cancer claim 25 , multiple myeloma claim 25 , colorectal cancer claim 25 , non-small cell lung cancer claim 25 , or diffuse large B-cell lymphoma.27. The method of claim 25 , wherein the patient is selected for treatment based on gene amplification and/or elevated tumor expression of USP7 claim 25 , MDM2 or MDM4 relative to tissue-matched expression.28. The method of claim 25 , wherein the patient is selected for the treatment based on tumor expression of wild type TP53.29. The method of claim 25 , wherein ...

PYRROLO AND PYRAZOLOPYRIMIDINES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS

The invention relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: 2. The compound of claim 1 , wherein Xis C or S(O).3. The compound of claim 1 , wherein Ris —OH or halogen.4. The compound of claim 1 , wherein Ris halogen or (C-C) alkoxy.5. The compound of claim 1 , wherein Rand R are independently H or (C-C) alkyl.6. The compound of claim 1 , wherein Ris H or (C-C) alkyl.7. The compound of claim 1 , wherein Ris H claim 1 , (C-C) alkyl claim 1 , or aryl.8. The compound of claim 1 , wherein n is 1.19. The compound of selected from the group consisting of:5-{[4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl]methyl}-1-methyl-1H,4H, 5H-pyrazolo[3,4-d]pyrimidin-4-one;4-({4-[4-hydroxy-4-({1-methyl-4-oxo-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-5-yl}methyl)piperidine-1-carbonyl]phenyl}methoxy)benzonitrile;1-(4-fluorophenyl)-5-((4-hydroxy-1-(4-(5-methyl-5,6-dihydropyrrolo[3,4-c]pyrazol-1(4H)-yl)benzoyl)piperidin-4-yl)methyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one;1-(4-fluorophenyl)-5-{[4-hydroxy-1-(4-{5-methyl-2H,4H, 5H, 6H-pyrrolo[3,4-c]pyrazol-2-yl}benzoyl)piperidin-4-yl]methyl}-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one;2-(4-(4-(4-((1-(4-fluorophenyl)-4-oxo-1H-pyrazolo[3,4-d]pyrimidin-5 (4H)-yl)methyl)-4-hydroxypiperidine-1-carbonyl)phenyl)-1H-pyrazol-1-yl)acetamide;5-((1-((2R,4S)-1-acryloyl-4-methylazetidine-2-carbonyl)-4-hydroxypiperidin-4-yl)methyl)-1-(4-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one;5-{[1-(4-{2, 5-diazabicyclo[2.2.1]heptan-2-yl}benzoyl)-4-hydroxypiperidin-4-yl]methyl}-1-(4-fluorophenyl)-1H,4H, 5H-pyrazolo[3,4-d]pyrimidin-4-one;1-(4-fluorophenyl)-5-[(4-hydroxy-1-{4-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]benzoyl}piperidin-4-yl)methyl]-1H,4H, 5H-pyrazolo[3,4-d]pyrimidin-4-one;5-((1-(4-fluorobenzoyl)-4-hydroxypiperidin-4-yl)methyl)-1-( ...

PYRROLOTRIAZINONES AND IMIDAZOTRIAZINONES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS

The invention relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: 2. The compound of claim 1 , wherein Xis C.3. The compound of claim 1 , wherein Xis N.4. The compound of claim 1 , wherein Xis CR.5. The compound of claim 1 , wherein Ris —OH.6. The compound of claim 1 , wherein Ris H or (C-C) alkyl.7. The compound of claim 1 , wherein Ris H.8. The compound of claim 1 , wherein R is H.9. The compound of claim 1 , wherein Ris H.10. The compound of claim 1 , wherein Ris H claim 1 , halogen claim 1 , —NRC(O)R claim 1 , or —NRC(O)NRR.1214.-. (canceled)16. (canceled)18. (canceled)20. The compound of selected from the group consisting of:3-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)methyl)pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one;3-((1-([1,1′-biphenyl]-2-carbonyl)-4-hydroxypiperidin-4-yl)methyl)pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one;3-((4-hydroxy-1-(2-(thiophen-3-yl)benzoyl)piperidin-4-yl)methyl)pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one;3-((1-(3′-fluoro-[1,1′-biphenyl]-2-carbonyl)-4-hydroxypiperidin-4-yl)methyl)pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one;3-((1-(3-(benzo[d][1,3]dioxol-5-yl)benzoyl)-4-hydroxypiperidin-4-yl)methyl)pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one;3-((4-hydroxy-1-(2′-methyl-[1,1′-biphenyl]-3-carbonyl)piperidin-4-yl)methyl)pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one;3-((4-hydroxy-1-(4′-methyl-[1,1′-biphenyl]-3-carbonyl)piperidin-4-yl)methyl)pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one;3-((4-hydroxy-1-(4′-methoxy-[1,1′-biphenyl]-3-carbonyl)piperidin-4-yl)methyl)pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one;3-((1-(4′-fluoro-3′-methyl-[1,1′-biphenyl]-3-carbonyl)-4-hydroxypiperidin-4-yl)methyl)pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one;3-((4-hydroxy-1-(3′-methoxy-[1,1′-biphenyl]-3-carbonyl)piperidin-4-yl)methyl)pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one;3-((1 ...

Method of fabricating heterojunction battery

The present invention discloses a method of fabricating a heterojunction battery, comprising the steps of: depositing a first amorphous silicon intrinsic layer on the front of an n-type silicon wafer, wherein the n-type silicon wafer may be a monocrystal or polycrystal silicon wafer; depositing an amorphous silicon p layer on the first amorphous silicon intrinsic layer; depositing a first boron doped zinc oxide thin film on the amorphous silicon p layer; forming a back electrode and an Al-back surface field on the back of the n-type silicon wafer; and forming a positive electrode on the front of the silicon wafer. In addition, the present invention further discloses a method of fabricating a double-sided heterojunction battery. In the present invention, the boron doped zinc oxide is used as an anti-reflection film in place of an ITO thin film; due to the special nature, especially the light trapping effect of the boron doped zinc oxide, the boron doped zinc oxide can achieve good anti-reflection. Therefore, the step of texturization is removed and the fabrication process simplified. As polycrystal silicon texturization is more challenging, the present invention is of more significance to heterojunction batteries using a polycrystal silicon wafer.

THIENOPYRIMIDINONES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS

The disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: 2. The compound of claim 1 , wherein Xis C.3. The compound of claim 1 , wherein Ris —OH.4. The compound of claim 1 , wherein Ris (C-C) aryl or heteroaryl.5. The compound of claim 1 , wherein Ris H.6. The compound of claim 1 , wherein R is H.7. The compound of claim 1 , wherein is Ris H claim 1 , (C-C) alkyl claim 1 , or (C-C) aryl.8. The compound of claim 1 , wherein Ris H claim 1 , (C-C) alkyl claim 1 , or (C-C) aryl.9. The compound of claim 1 , wherein Rand Rtogether with the atoms to which they are attached form a (C-C)cycloalkyl optionally substituted with one or more R.10. The compound of claim 1 , wherein n is 1.1318-. (canceled)20. The compound of selected from the group consisting of:3-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)methyl)thieno[2,3-d]pyrimidin-4(3H)-one;3-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)methyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one;3-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)methyl)-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one;3-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)methyl)-6-propylthieno[2,3-d]pyrimidin-4(3H)-one;3-((4-hydroxy-1-(3-phenylpentanoyl)piperidin-4-yl)methyl)thieno[2,3-d]pyrimidin-4(3H)-one;3-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)methyl)-6-methylthieno[2,3-d]pyrimidin-4(3H)-one;6-ethyl-3-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)methyl)thieno[2,3-d]pyrimidin-4(3H)-one;3-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)methyl)-5,6-dimethylthieno[2,3-d]pyrimidin-4(3H)-one;7-(4-fluorophenyl)-3-((4-hydroxy-1-(4-methoxybenzoyl)piperidin-4-yl)methyl)thieno[3,2-d]pyrimidin-4(3H)-one;3-((1-benzoyl-4-hydroxypiperidin-4-yl)methyl)-7-(4-fluorophenyl)thieno[3, ...

ISOTHIAZOLOPYRIMIDINONES, PYRAZOLOPYRIMIDINONES, AND PYRROLOPYRIMIDINONES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS

The disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: 2. The compound of claim 1 , wherein Xis C.3. The compound of claim 1 , wherein Xis S and Xis N.4. The compound of claim 1 , wherein Xis NRand Xis CR.5. The compound of claim 1 , wherein Ris OH.6. The compound of claim 1 , wherein Ris H (C-C) aryl claim 1 , or heteroaryl.7. The compound of claim 1 , wherein Ris H.8. The compound of claim 1 , wherein R is H.9. The compound of claim 1 , wherein is Ris H.10. The compound of claim 1 , wherein Ris H.1419-. (canceled)20. The compound of selected from the group consisting of:6-{[1-(4-fluorobenzoyl)-4-hydroxypiperidin-4-yl]methyl}-3-phenyl-6H,7H-[1,2]thiazolo[4,5-d]pyrimidin-7-one;6-{[1-(4-fluorobenzoyl)-4-hydroxypiperidin-4-yl]methyl}-3-(4-methoxyphenyl)-6H,7H-[1,2]thiazolo[4,5-d]pyrimidin-7-one;3-(4-fluorophenyl)-6-{[4-hydroxy-1-(4-methoxybenzoyl)piperidin-4-yl]methyl}-6H,7H-[1,2]thiazolo[4,5-d]pyrimidin-7-one;6-{[1-(4-fluorobenzoyl)-4-hydroxypiperidin-4-yl]methyl}-3-[3-(hydroxymethyl)phenyl]-6H,7H-[1,2]thiazolo[4,5-d]pyrimidin-7-one;6-{[1-(4-fluorobenzoyl)-4-hydroxypiperidin-4-yl]methyl}-3-(4-fluorophenyl)-1H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one;6-{[1-(4-fluorobenzoyl)-4-hydroxypiperidin-4-yl]methyl}-3-(4-methoxyphenyl)-1H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one;6-{[4-hydroxy-1-(4-methoxybenzoyl)piperidin-4-yl]methyl}-3-phenyl-1H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one;6-{[4-hydroxy-1-(4-methoxybenzoyl)piperidin-4-yl]methyl}-3-phenyl-6H,7H-[1,2]thiazolo[4,5-d]pyrimidin-7-one;3-(4-fluoro-3-methoxyphenyl)-6-[{-(4-fluorobenzoyl)-4-hydroxypiperidin-4-yl]methyl}-6H,7H-[1,2]thiazolo[4,5-d]pyrimidin-7-one;3-(4-fluorophenyl)-6-({4-hydroxy-1-[5-(4-methylpiperazin-1-yl)pyridine-2-carbonyl]piperidin-4-yl}methyl)-6H,7H-[1,2]thiazolo[4,5-d] ...

SUPERHIGH TORSIONAL STRENGTH, METALLIC AND AIRTIGHT DRILLROD COUPLER

The present invention discloses a superhigh torsional strength, metallic and airtight drillrod coupler, which comprises: an externally threaded coupler, which has a radially outward outer shoulder at an end thereof in an axial direction and an inner end face at the other end thereof in the axial direction, with an externally threaded section and a first sealing face being provided in sequence in the axial direction of the externally threaded coupler from the outer shoulder to the inner end face; and an internally threaded coupler to be threadedly connected to said externally threaded coupler, the internally threaded coupler having a radially inward inner shoulder at an end thereof in an axial direction and an outer end face at the other end thereof in the axial direction, with a second sealing face and an internally threaded section to be engaged with the externally threaded section being provided in sequence in the axial direction of the internally threaded coupler from the inner shoulder to the outer end face; wherein said inner end face mates with a shoulder face of the inner shoulder, and the outer end face mates with a shoulder face of the outer shoulder; and the first sealing face and the second sealing face are both sloped faces, and are in an interference-fit sealed connection with each other. The drillrod coupler has a relatively high torsional strength, good airtight sealing performance, and good performance in terms of repeated threaded connection and disconnection. 1. a superhigh torsional strength , metallic and airtight drillrod coupler , comprising:an externally threaded coupler, which has a radially outward outer shoulder at an end thereof in an axial direction and an inner end face at the other end thereof in the axial direction, with an externally threaded section and a first sealing face being provided in sequence in the axial direction of the externally threaded coupler from the outer shoulder to the inner end face; andan internally threaded ...

Thienopyrimidinones as ubiquitin-specific protease 7 inhibitors

The disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula:where R1, R2, R3, R5, R5′, X1, X2, n, and m are described herein.

PYRROLO AND PYRAZOLOPYRIMIDINES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS

The invention relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: 113-. (canceled)17. The compound of claim 14 , having Formula (Ic):or a pharmaceutically acceptable salt thereof.25. A pharmaceutical composition comprising claim 14 , a compound of or a pharmaceutically acceptable salt thereof claim 14 , and a pharmaceutically acceptable carrier.26. A method of treating a disease or disorder associated with modulation of USP7 comprising claim 14 , administering to a patient in need thereof an effective amount of a compound of .27. A method of inhibiting USP7 comprising administering to a patient in need thereof an effective amount of a compound of .28. A method of treating cancer claim 14 , the method comprising administering to a patient in need thereof an effective amount of a compound of .29. A method of treating a neurodegenerative disease claim 14 , the method comprising administering to a patient in need thereof an effective amount of a compound of .30. A method of treating a viral infection and disease claim 14 , the method comprising administering to a patient in need thereof an effective amount of a compound of .31. A method of treating an inflammatory disease or condition claim 14 , the method comprising administering to a patient in need thereof an effective amount of a compound of .32. A method of inducing cell cycle arrest claim 14 , apoptosis in tumor cells claim 14 , and/or enhanced tumor specific T-cell immunity claim 14 , the method comprising contacting the cells with an effective amount of a compound of . This application claims the benefit of and priority to U.S. provisional application No. 62/098,141, filed Dec. 30, 2014, the entire contents of which are incorporated herein by reference in its entirety.The present ...

PYRROLOTRIAZINONES AND IMIDAZOTRIAZINONES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS

The invention relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: 2. The compound of claim 1 , wherein Ris H.3. The compound of claim 2 , wherein Ris H.4. The compound of claim 3 , wherein Ris (C-C) alkyl claim 3 , wherein the alkyl is optionally substituted with one or more R.5. The compound of claim 4 , wherein Ris (C-C) alkyl claim 4 , wherein the alkyl is substituted with one or more R.6. The compound of claim 5 , wherein Ris (C-C) alkyl claim 5 , wherein the alkyl is substituted with —(C-C)-alkylene-aryl.7. The compound of claim 5 , wherein Ris (C-C) alkyl claim 5 , wherein the alkyl is substituted with —(C-C)-alkylene-heteroaryl.8. The compound of claim 1 , wherein the compound is (R)-3-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)methyl)pyrrolo[2 claim 1 ,1-f][1 claim 1 ,2 claim 1 ,4]triazin-4(3H)-one.9. The compound of claim 1 , wherein the compound is 3-((1-(3-(1H-pyrrol-1-yl)butanoyl)-4-hydroxypiperidin-4-yl)methyl)pyrrolo[2 claim 1 ,1-f][1 claim 1 ,2 claim 1 ,4]triazin-4(3H)-one.10. A pharmaceutical composition comprising a compound of claim 1 , or a pharmaceutically accepted salt thereof claim 1 , and a pharmaceutically accepted carrier.11. A pharmaceutical composition comprising a compound of claim 8 , or a pharmaceutically accepted salt thereof claim 8 , and a pharmaceutically accepted carrier.12. A pharmaceutical composition comprising a compound of claim 9 , or a pharmaceutically accepted salt thereof claim 9 , and a pharmaceutically accepted carrier. This application claims the benefit of and priority to U.S. provisional application No. 62/098,145, filed Dec. 30, 2014, the entire contents of which are incorporated herein by reference in its entirety.The present invention is directed to inhibitors of ubiquitin- ...

DNA Polymerase IIIC Inhibitors and Use Thereof

The present invention relates to compounds and methods useful for inhibiting the DNA polymerase IIIC enzyme. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of Gram-positive bacterial infections. 2. A compound as in claim 1 ,wherein A and B are N;wherein n is 1;{'sub': 1', '2', 'm', 'o', '2', 'p', 'q, 'wherein Ris (CH)—{(V)—(CH)}—W;'}{'sub': '2', 'wherein V is CH, CO, O, OC(O), or (O)CO,'}{'sub': 2', '10, 'wherein W is H, halo, substituted or unsubstituted C1-6 alkyl, NH, CN, or OR,'}{'sub': 10', '1-6, 'wherein Ris H or substituted or unsubstituted Calkyl,'}in which m is 1-5, o is 0-4, p is 0-4, and q is 0-4;{'sub': '2', 'wherein Ris H, CN, F, or Cl;'}{'sub': '3', 'wherein Ris a 3- or 4-F, Cl, Me, or ethyl substituted phenyl group, a 3,4-dichloro, 3,4-difluoro, 3-Me-4-Cl, 3-Me-4-F, 3-Cl-4-Me, 3-F-4-Me, 3-ethyl-4-Cl, 3-ethyl-4-F, 3-Cl-4-ethyl, or 3-F-4-ethyl substituted phenyl group; a benzo[d][1,3]dioxole group; a 2,2-dimethylbenzo[d]-[1,3]dioxole group; or a 2,2-difluorobenzo[d][1,3]dioxole group;'}{'sub': '0', 'wherein Ris H,'}or an optical isomer thereof, an isotopic isomer thereof, a prodrug or a pharmaceutically acceptable salt thereof.3. A compound as in claim 2 ,wherein A and B are N;wherein n is 1;{'sub': 1', '2', 'm', 'o', '2', 'p', 'q, 'wherein Ris (CH)—{(V)—(CH)}—W;'}wherein V is CO, O, OC(O), or (O)CO,{'sub': 2', '10, 'wherein W is H, halo, NH, CN, or OR,'}{'sub': 10', '1-6, 'wherein Ris H or substituted or unsubstituted Calkyl,'}in which m is 1-5, o is 0-1, p is 0-4, and q is 0-4;{'sub': '2', 'wherein Ris H, CN, F, or Cl;'}{'sub': '3', 'wherein Ris a 3- or 4-F, Cl, Me, or ethyl substituted phenyl group; a 3,4-dichloro, 3,4-difluoro, 3-Me-4-Cl, 3-Me-4-F, 3-Cl-4-Me, 3-F-4-Me, 3-ethyl-4-Cl, 3-ethyl-4-F, 3-Cl-4-ethyl, or 3-F-4-ethyl substituted phenyl group; a benzo[d][1,3]dioxole group; a 2,2-dimethylbenzo[d]-[1,3]dioxole group; or a 2 ...

DNA Polymerase IIIC Inhibitors and Use Thereof

The present invention relates to compounds and methods useful for inhibiting the DNA polymerase IIIC enzyme. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of Gram-positive bacterial infections. 28.-. (canceled)9. The method of claim 1 , wherein said surface is a surface of a medical device.11. (canceled)12. A method of inhibiting the growth of Gram-positive bacteria claim 1 , said method comprising contacting a medium with an effective amount of a compound selected from the group consisting of:5-((3,4-Dichlorobenzyl)amino)-1-methyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one,5-((3,4-Dichlorobenzyl)amino)-3-fluoro-1-methyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one,1-Allyl-5-((3,4-dichlorobenzyl)amino)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one,4-(5-((3,4-Dichlorobenzyl)amino)-7-oxo-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-1-yl)butyl acetate,1-(Cyclobutylmethyl)-5-((3,4-dichlorobenzyl)amino)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one,5-[(3,4-Cichlorophenyl)methylamino]-1-phenyl-6H-pyrazolo[4,3-d]pyrimidin-7-one,1-Cyclopropyl-5-((3,4-dichlorobenzyl)amino)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one,Cyclopentyl-5-((3,4-dichlorobenzyl)amino)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one,Cethyl 5-(5-chloro-7-methoxy-pyrazolo[4,3-d]pyrimidin-1-yl) pentanoate,5-[(3,4-Cichlorophenyl)methylamino]-1-(4-pyridyl)-6H-pyrazolo[4,3-d]pyrimidin-7-one,3-Chloro-5-((3,4-dichlorobenzyl)amino)-1-(2-methoxyethyl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one,5-((3,4-Cichlorobenzyl)amino)-3-fluoro-1-(2-methoxyethyl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one,3-Chloro-5-((3,4-dichlorobenzyl)amino)-1-(oxazol-4-ylmethyl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one,1-(2-(4-Acetylpiperazin-1-yl)ethyl)-5-((3,4-dichlorobenzyl)amino)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one hydrochloride,5-((3,4-Dichlorobenzyl)amino)-1-(2-(2-hydroxyethoxy)ethyl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one,5-((3,4-Dichlorobenzyl)amino)-1-(2-methoxyethyl ...

PURINONES AS UBIQUITIN-SPECIFIC PROTEASE 1 INHIBITORS

The application relates to inhibitors of USP1 useful in the treatment of cancers, and other USP1 associated diseases and disorders, having the Formula: 141-. (canceled)43. A pharmaceutical composition comprising the compound of claim 42 , or a pharmaceutically acceptable salt thereof claim 42 , and a pharmaceutically acceptable carrier in a unit dosage form.45. The composition of claim 44 , wherein the first base is KCO.46. The composition of claim 44 , wherein the palladium catalyst is Pd(dppf)Cl.CHCl.49. The composition of claim 48 , wherein the metal is iron powder.51. The composition of claim 50 , wherein the second base is N claim 50 ,N-diisopropylethylamine (DIEA). This application claims the benefit of and priority to U.S. provisional application No. 62/258,162, filed Nov. 20, 2015, the entire contents of which are incorporated herein by reference in its entirety.The present application is directed to inhibitors of ubiquitin-specific protease 1 (USP1) useful in the treatment of diseases or disorders associated with USP1 enzymes. Specifically, the application is concerned with compounds and compositions thereof, which inhibit USP1, methods of treating diseases or disorders associated with USP1, and methods of synthesis of these compounds.Ubiquitination is a reversible process which involves a family of deubiquitinating enzymes (DUBs) that regulate a variety of cellular processes by deconjugating ubiquitin from the substrate. DUBs are encoded by approximately 100 human genes and are classified into six families, with the largest family being the ubiquitin-specific proteases (USPs) that has more than 50 members. DUBs and their substrate proteins are often deregulated in cancers, supporting the hypothesis that targeting specific DUB family members may result in antitumor activity through enhancing the ubiquitination and subsequent degradation of oncogenic substrates and the activity of other key proteins involved in tumor growth, survival, differentiation and ...

PYRROLO AND PYRAZOLOPYRIMIDINES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS

The invention relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: 147-. (canceled)49. The compound of claim 48 , wherein Ris aryl claim 48 , optionally substituted with one or more R.50. The compound of claim 49 , wherein Ris aryl.51. The compound of claim 50 , wherein Ris heterocyclyl claim 50 , optionally substituted with one or more R.52. The compound of claim 51 , wherein Ris —C(O)Rand Ris (C-C) alkenyl.53. The compound of claim 49 , wherein Ris halogen.54. The compound of claim 53 , wherein Ris (C-C) alkyl claim 53 , optionally substituted with one or more R.55. The compound of claim 54 , wherein Ris independently selected from heteroaryl and halogen claim 54 , wherein heteroaryl is substituted with one or more R claim 54 , and wherein Ris halogen.56. The compound of claim 53 , wherein Ris (C-C) cycloalkyl claim 53 , optionally substituted with one or more R.57. The compound of claim 56 , wherein Ris O-heteroaryl claim 56 , wherein heteroaryl is substituted with one or more R claim 56 , and wherein Ris (C-C) alkyl.58. The compound of claim 49 , wherein Ris —O—(C-C)cycloalkyl claim 49 , optionally substituted with one or more R claim 49 , and wherein Ris halogen.59. The compound of claim 58 , wherein Ris (C-C) cycloalkyl claim 58 , optionally substituted with one or more R.60. The compound of claim 59 , wherein Ris (C-C) alkyl.61. The compound of claim 48 , wherein Ris (C-C) alkyl.62. The compound of claim 61 , wherein Ris aryl claim 61 , optionally substituted with one or more R.63. The compound of claim 62 , wherein:{'sub': 8', '9, 'Ris aryl, optionally substituted with one or more R;'}{'sub': 9', '10', 'q', '11, 'Ris —NRS(O)R;'}{'sub': '10', 'Ris H; and'}{'sub': 11', '2', '6, 'Ris (C-C) alkenyl.'}64. The compound of claim 48 , ...

PYRROLOTRIAZINONES AND IMIDAZOTRIAZINONES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS

The invention relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: 147-. (canceled)49. The compound of claim 48 , wherein Ris (C-C) aryl claim 48 , optionally substituted with one or more R.50. The compound of claim 49 , wherein Ris (C-C) aryl.51. The compound of claim 50 , wherein Ris heterocycloalkyl claim 50 , optionally substituted with one or more R.52. The compound of claim 51 , wherein Ris —C(O)Rand Ris (C-C) alkenyl.53. The compound of claim 49 , wherein Ris halogen.54. The compound of claim 53 , wherein Ris (C-C) alkyl claim 53 , optionally substituted with one or more R.55. The compound of claim 54 , wherein Ris independently selected from heteroaryl and halogen claim 54 , wherein heteroaryl is substituted with one or more R claim 54 , and wherein Ris halogen.56. The compound of claim 53 , wherein Ris cycloalkyl claim 53 , optionally substituted with one or more R.57. The compound of claim 56 , wherein Ris O-heteroaryl claim 56 , wherein heteroaryl is substituted with one or more R claim 56 , and wherein Ris (C-C) alkyl.58. The compound of claim 49 , wherein Ris —O—(C-C)cycloalkyl claim 49 , optionally substituted with one or more substituents independently selected from halogen.59. The compound of claim 58 , wherein Ris cycloalkyl claim 58 , optionally substituted with one or more R.60. The compound of claim 59 , wherein Ris (C-C) alkyl.61. The compound of claim 48 , wherein Ris (C-C) alkyl.62. The compound of claim 61 , wherein Ris aryl claim 61 , optionally substituted with one or more R.63. The compound of claim 62 , wherein:{'sub': 8', '9, 'Ris aryl, optionally substituted with one or more R;'}{'sub': 9', '14', 'q', '15, 'Ris —NRS(O)R;'}{'sub': '14', 'Ris H; and'}{'sub': 15', '2', '6, 'Ris (C-C) alkenyl.'}64. A ...

THIENOPYRIMIDINONES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS

The disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: 2. The compound of claim 1 , wherein Xis C.3. The compound of anyone of or claim 1 , wherein Ris —OH.4. The compound of anyone of to claim 1 , wherein Ris (C-C) aryl or heteroaryl.5. The compound of anyone of to claim 1 , wherein Ris H.6. The compound of anyone of to claim 1 , wherein R is H.7. The compound of anyone of to claim 1 , wherein is Ris H claim 1 , (C-C) alkyl claim 1 , or (C-C) aryl.8. The compound of anyone of to claim 1 , wherein Ris H claim 1 , (C-C) alkyl claim 1 , or (C-C) aryl.9. The compound of anyone of to claim 1 , wherein Rand Rtogether with the atoms to which they are attached form a (C-C)cycloalkyl optionally substituted with one or more R.10. The compound of anyone of to claim 1 , wherein n is 1.20. The compound of selected from the group consisting of:3-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)methyl)thieno[2,3-d]pyrimidin-4(3H)-one;3-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)methyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one;3-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)methyl)-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one;3-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)methyl)-6-propylthieno[2,3-d]pyrimidin-4(3H)-one;3-((4-hydroxy-1-(3-phenylpentanoyl)piperidin-4-yl)methyl)thieno[2,3-d]pyrimidin-4(3H)-one;3-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)methyl)-6-methylthieno[2,3-d]pyrimidin-4(3H)-one;6-ethyl-3-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)methyl)thieno[2,3-d]pyrimidin-4(3H)-one;3-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)methyl)-5,6-dimethylthieno[2,3-d]pyrimidin-4(3H)-one;7-(4-fluorophenyl)-3-((4-hydroxy-1-(4-methoxybenzoyl)piperidin-4-yl)methyl)thieno[3,2-d] ...

Thienopyrimidinones as ubiquitin-specific protease 7 inhibitors

where R1, R2, R3, R5, X1, X2, n, and m are described herein.

Isothiazolopyrimidinones, pyrazolopyrimidinones, and pyrrolopyrimidinones as ubiquitin-specific protease 7 inhibitors

where R1, R2, R3, R4, R5, R5′, X1, X2, X3, n, and m are described herein.

PYRROLO AND PYRAZOLOPYRIMIDINES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS

The invention relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: 1. The compound of claim 14 , wherein the compound is 5-({1-[(3S)-4 claim 14 ,4-difluoro-3-(4-fluoro-1H-pyrazol-1-yl)butanoyl]-4-hydroxypiperidin-4-yl}methyl)-1-(4-fluorophenyl)-1H claim 14 ,4H claim 14 ,5H-pyrazolo[3 claim 14 ,4-d]pyrimidin-4-one claim 14 , or a pharmaceutically acceptable salt thereof.212-. (canceled)13. A pharmaceutical composition comprising a compound of claim 1 , or a pharmaceutically accepted salt thereof claim 1 , and a pharmaceutically accepted carrier.15. The compound of claim 14 , wherein Ris —(C-C) alkylene-phenyl claim 14 , wherein phenyl is optionally substituted with one or more R.16. The compound of claim 15 , wherein Ris —(C-C) alkylene-phenyl claim 15 , wherein phenyl is substituted with one R.17. The compound of claim 16 , wherein Ris halogen.18. The compound of claim 17 , wherein Ris fluorine.19. The compound of claim 18 , wherein Ris (C-C) cycloalkyl optionally substituted with one or more R.20. The compound of claim 19 , wherein Ris cyclohexyl optionally substituted with one or more R.21. The compound of claim 20 , wherein Ris cyclohexyl substituted with one R.22. The compound of claim 21 , wherein Ris —(C-C)-alkylene-O-heteroaryl.23. The compound of claim 22 , wherein Ris —O-pyridyl.24. The compound of claim 16 , wherein Ris aryl optionally substituted with one or more R.25. The compound of claim 24 , wherein Ris phenyl optionally substituted with one or more R.26. The compound of claim 25 , wherein Ris phenyl substituted with one R.27. The compound of claim 26 , wherein Ris trifluoromethyl.28. The compound of claim 27 , wherein Ris heterocyclyl.29. The compound of claim 28 , wherein Ris piperazinyl.30. A pharmaceutical ...

Carbonate-based anti-caking agent with reduced gas release properties

The present invention provides carbonate-based anti-caking agents with reduced gassing properties and methods for preparing these anti-caking agents. The carbonate-based core material is encapsulated with encapsulating agents, which possess properties that can decrease the contact between the carbonate-based core material and its outer environment to minimize the production of carbon dioxide in the headspace of food package.

Pyrrolotriazinones and imidazotriazinones as ubiquitin-specific protease 7 inhibitors

The invention relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where R 1 , R 2 , R 3 , R 4 , R 5 , R 5′ , R 6 , X 1 , X 2 , m, and n are described herein.

Binding post housing

本实用新型公开了一种接线端子罩壳，包括底壳、内密封条、内齿轮和工作螺栓，所述底壳的底面上固定有内密封条和固定卡板，且底壳的底面上开设有底螺纹孔，并且底壳的边侧固定有凸条，所述固定卡板与定位槽相互连接，且定位槽开设在顶壳边侧底部，并且顶壳顶部开设有贯穿螺纹孔，同时贯穿螺纹孔内安装有紧固螺栓，所述顶壳的垂直部分内侧开设有侧槽，且顶壳顶部开设有顶螺纹孔，并且顶壳边侧固定有触发板，所述底壳垂直部分顶端安装有内齿轮。该接线端子罩壳，采用新型的结构设计，使得本装置可以稳定的接触连接，对接线端子进行稳定的隔离保护，且组装操作便捷，结构强度较高，可以用于对尺寸较大的接线端子的隔离保护。

Purinones as ubiquitin-specific protease 1 inhibitors

The application relates to inhibitors of USP1 useful in the treatment of cancers, and other USP1 associated diseases and disorders, having the Formula: (I), where R 1 , R 2 , R 3 , R 3' , R 4 , R 5 , X 1 , X 2 , X 3 , X 4 , and n are described herein.

Method of fabricating heterojunction battery

The present invention discloses a method of fabricating a heterojunction battery, comprising the steps of: depositing a first amorphous silicon intrinsic layer on the front of an n-type silicon wafer, wherein the n-type silicon wafer may be a monocrystal or polycrystal silicon wafer; depositing an amorphous silicon p layer on the first amorphous silicon intrinsic layer; depositing a first boron doped zinc oxide thin film on the amorphous silicon p layer; forming a back electrode and an Al-back surface field on the back of the n-type silicon wafer; and forming a positive electrode on the front of the silicon wafer. In addition, the present invention further discloses a method of fabricating a double-sided heterojunction battery. In the present invention, the boron doped zinc oxide is used as an anti-reflection film in place of an ITO thin film; due to the special nature, especially the light trapping effect of the boron doped zinc oxide, the boron doped zinc oxide can achieve good anti-reflection. Therefore, the step of texturization is removed and the fabrication process simplified. As polycrystal silicon texturization is more challenging, the present invention is of more significance to heterojunction batteries using a polycrystal silicon wafer.

Purinones as ubiquitin-specific protease 1 inhibitors

The application relates to inhibitors of USP1 useful in the treatment of cancers, and other USP1 associated diseases and disorders, having the Formula: (I), where R1, R2, R3, R3', R4, R5, X1, X2, X3, X4, and n are described herein.

Pyrrolotriazinone and imidazotriazinone derivatives as ubiquitin-specific protease 7 (usp7) inhibitors for the treatment of cancer

The invention relates to pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one and imidazo[5,1-f][1,2,4]triazin-4(3H)-one derivatives as inhibitors of the ubiquitin-specific protease 7 (USP7) useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula (I) where R l , R 2 , R 3 , R 4 , R s , R s' , R 6 , X l , X 2 , m, and n are described herein.

Sliding vane control structure for variable-capacity air cylinder, variable-capacity air cylinder and variable-capacity compressor

Provided is a sliding vane control structure for a variable-capacity cylinder, including a pin (113, 213) provided on a lower side of a sliding vane (11), the pin (113, 213) having a first position capable of stopping the sliding vane (11) and a second position capable of being separated from the sliding vane (11), wherein a low-pressure passage (115, 215) is provided under the pin (113, 213); and a surface seal structure is provided between the pin (113, 213) and the low-pressure passage (115, 215), and when the pin (113, 213) is at the second position, a surface seal is formed at a lower end of the pin (113, 213). Since the sliding vane control structure is provided with a surface seal structure, a seal effect of the surface seal is much better than that of a clearance seal, thereby greatly reducing a leakage of a refrigerant. Consequently, an efficiency of a compressor is increased when a variable-capacity cylinder is in a working mode, and a performance of the compressor is optimized. Also provided is the variable-capacity cylinder with the sliding vane control structure and a variable-capacity compressor.

Pirrolo and pyrazolopyrimidines as inhibitors of ubiquitin-specific protease 7.

<p>LA INVENCIÓN SE RELACIONA CON INHIBIDORES DE LA INHIBIDORES DE USP7 ÚTILES EN EL TRATAMIENTO DE CÁNCERES, ENFERMEDADES NEURODEGENERATIVAS, ALTERACIONES INMUNOLÓGICAS, ALTERACIONES INFLAMATORIAS, ENFERMEDADES CARDIOVASCULARES, ENFERMEDADES ISQUÉMICAS, ENFERMEDADES E INFECCIONES VIRALES Y ENFERMEDADES E INFECCIONES BACTERIANAS, DONDE X1 , X2 , R1-R5 , R5’ Y R6 SE DESCRIBEN EN EL PRESENTE.</p> <p> THE INVENTION IS RELATED TO INHIBITORS OF USP7 INHIBITORS USEFUL IN THE TREATMENT OF CANCERS, NEURODEGENERATIVE DISEASES, IMMUNE ALTERATIONS, INFLAMMATORY ALTERATIONS, CARDIOVASCULAR DISEASES, ILLNESSES, ILLNESSES, ILLNESSES, ILLNESSES, ILLNESSES, ILLNESSES, ILLNESSES, ILLNESSES, ILLNESSES, ILLNESSES, ILLNESSES, ILLNESSES, ILLNESSES, ILLNESSES, ILLNESSES, ILLNESSES, DISEASES , R1-R5, R5 'AND R6 ARE DESCRIBED IN THIS. </p>

Pyrrolo and pyrazolopyrimidines as ubiquitin-specific protease 7 inhibitors

The invention relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where m, n, X 1 , X 2 , R 1 -R 5 , R 5 and R 6 are described herein.

Pyrrolotriazinone and imidasotriazinone derivatives as obiquitin-specific protease 7 cusp? ) inhibitors for the treatment of cancer and other usp7 mediated diseases

The invention relates to pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one and imidazo[5,1-f][1,2,4]triazin-4(3H)-one derivatives as inhibitors of the ubiquitin-specific protease 7 (USP7) useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula (I) where R l , R 2 , R 3 , R 4 , R s , R s' , R 6 , X l , X 2 , m, and n are described herein.

PIRROLO AND PIRAZOLOPIRIMIDINAS AS INHIBITORS OF THE SPECIFIC PROTEASE 7 OF UBIQUITINA

Inhibidores de la inhibidores de USP7 útiles en el tratamiento de cánceres, enfermedades neurodegenerativas, alteraciones inmunológicas, alteraciones inflamatorias, enfermedades cardiovasculares, enfermedades isquémicas, enfermedades e infecciones virales y enfermedades e infecciones bacterianas. Reivindicación 1: Un compuesto de la fórmula (1), o una sal, hidrato, solvato, profármaco, esteroisómero y tautómero, farmacéuticamente aceptables, del mismo, en donde: X¹ es C, S, o S(O); X² es CR⁷ o N; R¹ es H, D, -OH, -SH, -NH₂, -NHC₁₋₄ alquil, -N(C₁₋₄ alquil)₂, o F; R² es C₁₋₈ alquil, aril, heteroaril, C₃₋₈ cicloalquil, heterociclil, -NR¹⁰R¹¹, o -OR¹⁰, en donde alquil, aril, cicloalquil y heterociclil se sustituyen opcionalmente por uno o más R⁸; cada R³ es independiente en cada aparición seleccionada de D, C₁₋₆ alquil, C₂₋₆ alquenil, C₂₋₆ alquinil, C₁₋₆ alcoxi, C₁₋₆ haloalquil, C₁₋₆ haloalcoxi, aril, heteroaril, C₃₋₈ cicloalquil, heterociclil, -CN, -OH, -C(O)R¹⁷, -C(O)OR¹⁷, -OC(O)OR¹⁷, -OC(O)NR¹⁷R¹⁸, -NR¹⁷R¹⁸, -NR¹⁷C(O)R¹⁸, -NR¹⁷C(O)OR¹⁸, C(O)NR¹⁷R¹⁸, -NR¹⁷C(O)NR¹⁷R¹⁸, -S(O)qNR¹⁷R¹⁸, -S(O)qR¹⁷R¹⁸, -NR¹⁷S(O)qR¹⁷R¹⁸, o halógeno, en donde alquil es sustituido opcionalmente por uno o más sustituyentes seleccionados independientemente en -OH o -NH₂; o dos R³ juntos cuando en carbonos adyacentes forman un cicloalquil C₃₋₈ sustituido opcionalmente por uno o más R¹⁹; o dos R³ juntos forman un espirocicloalquil C₃₋₈ que sustituido opcionalmente por uno o más R¹⁹; o dos R³ juntos forman un espiroheterociclil sustituido opcionalmente por uno o más R¹⁹; o dos R³ juntos cuando en carbonos adyacentes forman un anillo de aril sustituido opcionalmente por uno o más R¹⁹; o dos R³ juntos cuando en carbonos adyacentes forman un anillo de heteroaril sustituido opcionalmente por uno o mas R¹⁹; R⁴ es C₁₋₆ alquil, -C₀₋₃ alquileno, aril, heteroaril, C₃₋₈ cicloalquil, CD₃, o heterociclil, en donde aril, heteroaril, heterociclil y cicloalquil son sustituidos opcionalmente por uno o más R¹²; R⁵ ...

purinones as inhibitors of ubiquitin-specific protease 1

a presente invenção refere-se a inibidores da usp1 úteis no tratamento de cânceres, e outras doenças e distúrbios associados à usp1, com a fórmula (i), onde r1, r2, r3, r3', r4, r5, x1, x2, x3, x4, e n são descritos neste documento. The present invention relates to usp1 inhibitors useful in the treatment of cancers, and other usp1-associated diseases and disorders of formula (i), wherein r1, r2, r3, r3 ', r4, r5, x1, x2, x3, x4, and n are described in this document.

Purinones as ubiquitin-specific protease 1 inhibitors

【課題】ユビキチン特異的プロテアーゼ１阻害剤としてのプリノンを提供すること。【解決手段】本出願は、式（Ｉ）を有する、がん及び他のＵＳＰ１に関連する疾患及び障害の治療に有用なＵＳＰ１の阻害剤に関し、式中、Ｒ１、Ｒ２、Ｒ３、Ｒ３’、Ｒ４、Ｒ５、Ｘ１、Ｘ２、Ｘ３、Ｘ４、及びｎは本明細書に記載されるとおりである。本出願は、ユビキチン特異的プロテアーゼ１（ＵＳＰ１）酵素に関連する疾患または障害の治療に有用な、ＵＳＰ１の阻害剤を対象とする。詳細には、本出願は、ＵＳＰ１を阻害する化合物及びその組成物、ＵＳＰ１に関連する疾患または障害の治療方法、ならびにこれらの化合物の合成方法に関する。TIFF2023011899000384.tif4885【選択図】なし

DNA polymerase IIIC inhibitors and use thereof

The present invention relates to compounds and methods useful for inhibiting the DNA polymerase IIIC enzyme. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of Gram-positive bacterial infections.

Symmetric or semi-symmetric compounds useful as immunomodulators

A compound having Formula I:(I), or a pharmaceutical acceptable salt thereof. A is a bivalent arene or a bivalent heteroarene; Ring B and Ring B' are independently a 6-membered aromatic hydrocarbon ring, a 6-membered heterocyclic ring, a 8- to 10-membered aromatic hydrocarbon ring, or a 8- to 10-membered heterocyclic ring; Y and Y' are independently, null (direct bond), -CHR 1 -, -CH 2 -CH 2 -, -NR 1 -, -0-, -OCH 2 -, -CH 2 O-, -SCH 2 -, -CH 2 S-, -SOCH 2 -, -CH 2 SO-, or -SO 2 CH 2 -, and R 1 is H, C 1-6 alkyl, or C 3-6 cycloalkyl.

Dna polymerase iiic inhibitors and use thereof

The present invention relates to compounds and methods useful for inhibiting the DNA polymerase IIIC enzyme. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of Gram-positive bacterial infections.

Process of butadiene-1, 3 extraction

This invention presents a process of butadiene-1,3 extraction. The process consists of the procedure of 1st extractive fractionation, 2nd extractive fractionation, distillation and alkyne fractionation. This invention can improve the yield and capacity of butadiene extraction unit by adding an alkyne fractionator to the existing butadiene extraction unit and appropriately adjusting the process condition of 1st and 2nd extractive fractionators. This invention can decrease the energy and material consumption per unit of butadiene-1,3, which greatly improved the economic profit. The investment on various scales of butadiene extraction units for adding alkyne fractionator is almost same. Further more, the profit is in direct proportion with the scale of a plant and output is in several to some dozens of folds to investment. After the implementation of this invention, the discharge of vinyl acetylene offgas can be reduced by around 3400 tons per year, which mitigate the pollution on environment and save energy. The effect of energy saving and emission reduction is remarkable.

Hydroxamic acid derivative, preparation method therefor and application thereof

The present disclosure is related to the field of enzyme inhibitors, and in particular to a hydroxamic acid derivative, a method for producing the same and use thereof. The hydroxamic acid group of the hydroxamic acid derivative can be chelated with zinc ions in the LpxC active area, and the derivative has a hydrophobic side chain which can bind to hydrophic channels in the enzyme LpxC. These guarantee that the hydroxamic acid derivative has good bactericidal activity against Gram-negative bacteria and low toxicity. The present disclosure also provides a method for producing the hydroxamic acid derivative, which requires a shorter reaction time and can provide the derivative with a high yield.

Purinonas como inibidores da protease específica da ubiquitina 1 e composição farmacêutica compreendendo os referidos compostos

purinonas como inibidores da protease específica da ubiquitina 1. a presente invenção refere-se a inibidores da usp1 úteis no tratamento de cânceres, e outras doenças e distúrbios associados à usp1, com a fórmula (i), onde r1, r2, r3, r3', r4, r5, x1, x2, x3, x4, e n são descritos neste documento.

Purinones as ubiquitin-specific protease 1 inhibitors

R1 R5 N N= I X1, R N X2 R4Ray R4 X3 The application relates to inhibitors of USP1 useful in the treatment of cancers, and other USP1 associated diseases and disorders, having the Formula: (I), where R1, R2, R3, R3', R4, R5, X1, X2, X3, X4, and n are described herein.

Purinones as ubiquitin-specific protease 1 inhibitors

R1 R5 NN NN R2 iX R .X3 R 3 R3X4 n (I), The application relates to inhibitors of USP1 useful in the treatment of cancers, and other USP1 associated diseases and disorders, having the Formula: (I), where R 1, R2, R3, R3, Rt, Rs, X1, X2 , X3, X4 , and n are described herein.

Pyrrolo and pyrazolopyrimidines as ubiquitin-specific protease 7 inhibitors

The invention relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: (I) where m, n, X1, X2, R1-R5, R5' and R6 are described herein.

一种高压接线端子

本实用新型公开了一种高压接线端子，包括端子外壳主体和插口主体，所述端子外壳主体的内部安装有转杆，且转杆的上方设置有插口主体，并且插口主体的外侧安装有端子外壳主体，所述插口主体的下方设置有安装块，且安装块的后侧面固定有端子外壳主体，并且安装块的内部固定有气囊主体。该高压接线端子设置有固定块和竖杆，通过在盖板侧边的底部固定的固定块和竖杆，使得盖板在下降时，带动弧形的固定块和竖杆一同进行下降，使得竖杆对下方对应的安装块内部的气囊主体进行挤压，使得气囊主体向外扩张，因此通过气囊主体和橡胶垫的相互配合对插口主体外侧的电源线进行挤压防护，避免插口主体的松动，同时也能减少灰尘杂质的进入。

Compostos de pirrol e pirrazolpirimidinas, composição farmacêutica compreendendo os referidos compostos e uso

COMPOSTOS DE PIRROL E PIRRAZOLPIRIMIDINAS, COMPOSIÇÃO FARMACÊUTICA COMPREENDENDO OS REFERIDOS COMPOSTOS E USO. A invenção se refere a inibidores de inibidores de USP7 úteis no tratamento de cânceres, doenças neurodegenerativas, distúrbios imunológicos, distúrbios inflamatórios, doenças cardiovasculares, doenças isquêmicas, infecções e doenças virais e infecções e doenças bacterianas, que possui a Fórmula: (I), em que m, n, X1, X2, R1-R5, R5' e R6 são descritos no presente documento.

Pyrrolotriazinones and imidazotriazinones as ubiquitin-specific protease 7 inhibitors

The invention relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where R 1 , R 2 , R 3 , R 4 , R 5 , R 5′ , R 6 , X 1 , X 2 , m, and n are described herein.

一种电缆用接线端子

本实用新型公开了一种电缆用接线端子，包括接线端子本体、固定螺纹和连接块，所述接线端子本体的上端开设有对接孔，且接线端子本体的内表面固定连接有防滑块，所述接线端子本体的下端内表面开设有容置槽，且容置槽的内侧安装有活动块，并且活动块与接线端子本体相连接，所述固定螺纹固定连接在活动块的外表面，且活动块的下端固定连接有连接块，所述活动块的下端内表面开设有滑槽，且滑槽的外侧安装有限位块，并且限位块与活动块相连接。该电缆用接线端子，使用者只需手持活动块沿着接线端子本体的内侧转动，即可带动相连接的限位块对电缆端部进行挤压限位，提高了整体装置的安装牢固性。

Hydroxamic acid derivative, method for producing same and use thereof

The present disclosure is related to the field of enzyme inhibitors, and in particular to a hydroxamic acid derivative, a method for producing the same and use thereof. The hydroxamic acid group of the hydroxamic acid derivative can be chelated with zinc ions in the LpxC active area, and the derivative has a hydrophobic side chain which can bind to hydrophic channels in the enzyme LpxC. These guarantee that the hydroxamic acid derivative has good bactericidal activity against Gram-negative bacteria and low toxicity. The present disclosure also provides a method for producing the hydroxamic acid derivative, which requires a shorter reaction time and can provide the derivative with a high yield.

Cyanoethyl cellulose-based high-dielectric nano composite film and preparation method thereof

The present invention relates to a cyanoethyl cellulose-based high-dielectric nano composite film and a preparation method thereof and aims to provide a degradable high-dielectric flexible nano composite film with high dielectric constant, low dielectric loss, good mechanical properties and excellent thermal performance, and a preparation method thereof. The composite film is prepared by the following steps: preparing a solution from cyanoethyl cellulose as a base, graphene as a filler and montmorillonite as a dispersant by using a solvent, and forming the film by casting. The cyanoethyl cellulose for preparing the high-dielectric flexible nano composite film is a renewable source; the composite film is high in dielectric performance and low in dielectric loss, applicable to electronics, motor and cable industries and promising in the fields of artificial muscle, wave-absorbing materials and drug slow release; the production method is safe, the process is simple, and the production cost is low.

一种防尘接线端子排盖板

本实用新型公开了一种防尘接线端子排盖板，包括接线端子排本体、软毛刷、散热片、双向螺纹杆和把套，所述接线端子排本体的上方设置有顶板，且顶板的上表面安装有散热片，并且顶板的下方左右两侧对称设置有侧板，所述侧板的上端固定有连接块，且侧板的下方连接有软毛刷，并且连接块的内部贯穿有双向螺纹杆，所述双向螺纹杆的外侧设置有安装槽，且安装槽的内部设置有连接块，并且安装槽开设在顶板的下表面。该防尘接线端子排盖板设置有顶板、软毛刷和散热片，通过陶瓷材质的顶板能将接线端子排本体工作时产生的热量进行快速的吸收，顶板将热量传递到散热片的内部经散热片对热量进行散发，使装置具有良好的散热性，增加了装置的功能性。

Method for manufacturing superior 13Cr thickened drillrod

A method for manufacturing a superior 13Cr thickened drillrod comprises the following steps: firstly, thickening the ends of a steel tube with a composition so as to obtain a drillrod with thickened ends, the composition in percentage by weight being: C: 0.01-0.05%, Si≤0.5%, Mn: 0.2-1.0%, Cr: 12-14%, Mo: 1-3%, Ni: 4-6%, and a balance of Fe and inevitable impurities; after heating the tube as a whole to 950-1000° C., air cooling same and tempering same at 600-650° C.; and machining the two thickened ends respectively into an externally threaded drillrod coupler and an internally threaded drillrod coupler; wherein the tube end thickening is an external thickening, including three rounds of heating and three rounds of thickening, with at least one pass of deformation for each round, and the heating temperature being 1150-1200° C. for each round; and the upsetting pressure for the first round of external thickening is 180-220 bars, the upsetting pressure for the second round of external thickening is 180-220 bars, and the upsetting pressure for the third round of external thickening is 140-180 bars. The drillrod according to the present invention can be used not only as a drillrod but also as an oil tube, fulfilling requirements of the exploration operation of a CO2-containing gas field of compact sandstone with a high yield.

Technology to improve yield and capacity of the butadiene extraction facility which uses C4 as feedstock supplied by ethylene plant

This technology aims to improve yield and throughput of butadiene extraction facility which uses C 4 as feedstock supplied by ethylene plant. The key point of the technical solution is to properly broaden quality index of trans-butene-2 and cis-butene-2 in secondary rectification tower. In addition, an alkyne rectification tower is added to the extraction process. The main application is to improve the yield of butadiene extraction facility and its throughput. The major benefits are that butadiene yield is improved by 1% to 2% and the throughput is increased by 10%.

Spiro derivatives as m4 activators/modulators and uses thereof

The present disclosure provides compounds of Formula I: (l) (I), or an N- oxide thereof, or a pharmaceutically acceptable salt of the compound or the N-oxide, wherein: A, Y, m, n,p, R 1 , R 2 , R 3 , R 3a , R 4 , R 5 , R 6 , R 7 , and Z are as described herein; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds, N-oxides, or salts, and their uses for treating M4-mediated (or M4-associated) disorders including, e.g., Alzheimer's Disease, Parkinson's Disease, schizophrenia (e.g., its cognitive and negative symptoms), pain, addiction, and a sleep disorder.

Purinones as ubiquitin-specific protease 1 inhibitors

The application relates to inhibitors of USP1 useful in the treatment of cancers, and other USP1 associated diseases and disorders, having the Formula:where R1, R2, R3, R3′, R4, R5, X1, X2, X3, X4, and n are described herein.

Pyrrolo and pyrazolopyrimidines as ubiquitin-specific protease 7 inhibitors

The invention relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula:where m, n, X1, X2, R1-R5, R5′ and R6 are described herein.

Thienopyrimidinones as ubiquitin-specific protease 7 inhibitors

The disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where R 1 , R 2 , R 3 , R 5 , R 5′ , X 1 , X 2 , n, and m are described herein.

Pyrrolo and pyrazolopyrimidines as ubiquitin-specific protease 7 inhibitors

The invention relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where m, n, X 1 , X 2 , R 1 -R 5 , R 5′ and R 6 are described herein.