Interleukin-2 muteins for the expansion of T-regulatory cells

Provided herein are IL-2 muteins, IL-2 mutein Fc-fusion molecules, anti-IL-2 antibodies, and complexes comprising an anti IL-2 antibody bound to an IL-2 cytokine that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgGI Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also provided herein are linker peptides that are glycosylated when expressed in mammalian cells. Also provided herein are methods of making and using the compositions of the present invention.

Interleukin-2 muteins for the expansion of T-regulatory cells

Provided herein are IL-2 muteins, IL-2 mutein Fc-fusion molecules, anti-IL-2 antibodies, and complexes comprising an anti IL-2 antibody bound to an IL-2 cytokine that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgG1 Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also provided herein are linker peptides that are glycosylated when expressed in mammalian cells. Also provided herein are methods of making and using the compositions of the present invention.

Method for encapsulating and manufacturing glue perfusion molded SIM (subscriber identity module) film card with flip naked chip

The invention relates to a method for encapsulating and manufacturing a glue perfusion molded SIM (subscriber identity module) film card with a flip naked chip, which comprises the following steps of: directly flipping a thinned naked chip with a metal bump on a flexible circuit board of an SIM film card, and in a loading region of the SIM film card, using the glue to encapsulate the loading region of the flip naked chip by using the glue perfusion method. The SIM film card is produced by flipping the naked chip with the metal bump and pouring the glue, the thickness of the SIM film card and the consistency of the appearance are improved; and meanwhile, the stress state of the film card is improved due to the integral encapsulation effect of the glue so that the quality of the SIM film card is more stable and the batch processing can be realized. The film card can be prevented from damaging due to the extrusion and bending stress in the use process, so that the SIM card can be connected ...

Interleukin-2 muteins for the expansion of T-regulatory cells

Provided herein are IL-2 muteins, IL-2 mutein Fc-fusion molecules, anti-IL-2 antibodies, and complexes comprising an anti IL-2 antibody bound to an IL-2 cytokine that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgGI Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also provided herein are linker peptides that are glycosylated when expressed in mammalian cells. Also provided herein are methods of making and using the compositions of the present invention.

Entity type fused BERT knowledge graph completion method and system

The invention discloses an entity type fused BERT knowledge graph completion method and system, which take external knowledge of entity information, namely the entity type, as supplement of the entity information, better acquire semantic information of entities, improve text enhancement representation of a model input end, realize feature acquisition and sequence coding by using a Transformer encoder of a multi-head attention mechanism, and improve the semantic information of the entities and the text enhancement representation of a model input end. A small number of annotation triples are used for fine adjustment, excavation of implicit relations is effectively achieved, and multi-source heterogeneous data are cleaned rapidly and accurately.

BISPECIFIC ANTIBODIES AND METHODS OF MAKING AND USING THEREOF

INTERLEUKIN-2 MUTEINS FOR THE EXPANSION OF T-REGULATORY CELLS

Provided herein are IL-2 muteins, IL-2 mutein Fc-fusion molecules, anti-IL-2 antibodies, and complexes comprising an anti IL-2 antibody bound to an IL-2 cytokine that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgG1 Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also provided herein are linker peptides that are glycosylated when expressed in mammalian cells. Also provided herein are methods of making and using the compositions of the present invention.

Flexible polymer modified cement based waterproof material and its producing method

Low-temperature and low-damage moderate preprocessing method of PVA carrier pure-cotton high count yarn

The invention relates to a low-temperature and low-damage moderate preprocessing method of PVA carrier pure-cotton high count yarn, comprising the following steps: (1) yarn is preprocessed before processed, wherein the processing temperature of 20-80 DEG C, the processing temperature is 10-30 minutes, and conditioning fluid is 1-2g/L of Dj-13991; (2) at the room temperature, the specific scouring agent BF-07w of high count yarn, biological enzyme preparation, hydrogen peroxide and hydrogen peroxide activator (TAED/SPB) are successively added at the room temperature, and the pH value is adjusted to 7-9 by NaOH solution; (3) yarn is input, temperature rises to 40-80 DEG C which is kept for 20-90 minutes, the mixture is continuously stirred in the processing process, then temperature is lowered, and the obtained product is washed, dewatered and dried at the temperature of 50 DEG C. The invention effectively solves the adhesion problem between yarns which is caused by the dissolving of the ...

Blowout prevention pipeline base

The utility model discloses a blowout prevention pipeline base, and particularly relates to the technical field of pipeline foundation piers, the blowout prevention pipeline base comprises a supporting block, two sides of the supporting block are fixedly connected with weight boxes, the bottom end of each weight box is provided with a weight discharging structure, the top end of each weight box is provided with a feeding port, and the top end of each weight box is provided with a discharging port. Lifting rings are fixedly connected to the tops of the front ends of the weight boxes, drainage grooves are formed in the two sides of the top end of the supporting block, and an adjustable fixing structure is arranged at the top end of the supporting block. Through the arrangement of the base, the cladding plate, the rubber pad, the fixing bolt and the fixing screw hole, during use, the base is fixedly connected to the top end of the supporting block to support and fix the whole structure, then ...

Bispecific antibodies and methods of making and using thereof

The disclosure provides bispecific antibodies having the binding specificity to at least two of human CTLA4, PD-1 or PD-L1. In one embodiment, the bispecific antibody comprises IgG domains having heavy chains and light chains, and two scFv components being connected to either C-terminal of the heavy chains or N-terminal of the light chains, wherein the IgG domains have the binding specificity to a first antigen, wherein the scFv components have the binding specificity to a second antigen, and wherein the first antigen and the second antigen are different and are independently selected from a-CTLA4, α-PD-1, and α-PD-L1.

Guidance and navigation control proteins and method of making and using thereof

The application provides guidance and navigation control (GNC) proteins. In one embodiment, the guidance and navigation control (GNC) protein, comprising a binding domain for a T cell activating receptor, a binding domain for a tumor associated antigen, a bind domain for an immune checkpoint receptor, and a binding domain for a T cell co-stimulating receptor. The binding domain for the tumor associated antigen is not adjacent to the binding domain for the T cell co-stimulating receptor. In one embodiment, the binding domain for the T cell activating receptor is adjacent to the binding domain for the tumor associated antigen (TAA).

BISPECIFIC ANTIBODIES AND METHODS OF MAKING AND USING THEREOF

The disclosure provides bispecific antibodies having the binding specificity to at least two of human CTLA4, PD-1 or PD-L1. In one embodiment, the bispecific antibody comprises IgG domains having heavy chains and light chains, and two scFv components being connected to either C-terminal of the heavy chains or N-terminal of the light chains, wherein the IgG domains have the binding specificity to a first antigen, wherein the scFv components have the binding specificity to a second antigen, and wherein the first antigen and the second antigen are different and are independently selected from a-CTLA4, a-PD-1, and a-PD-L1.

Permanent-magnet synchronous generator having composite armature winding

The invention discloses a magneto alternator with composite armature winding composing a generator and an automatic voltage adjusting system. The generator is mainly composed of stator, rotor, armature winding, permanent magnet and casing. The stator armature winding or rotor armature winding are composite armature winding composing a main winding and one or several voltage regulating windings. The main winding can be single phase or multiple phase winding whose number of phase is the same for the voltage regulating winding. The automatic voltage regulation system can monitor the terminal voltage of the main winding through which to control the mode and number of the serial connection between the voltage regulation winding and the main winding.

Interleukin-2 muteins for the expansion of T-regulatory cells

Provided herein are IL-2 muteins, IL-2 mutein Fc-fusion molecules, anti-IL-2 antibodies, and complexes comprising an anti IL-2 antibody bound to an IL-2 cytokine that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgG1 Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also provided herein are linker peptides that are glycosylated when expressed in mammalian cells. Also provided herein are methods of making and using the compositions of the present invention.

Multi-specific antibodies and methods of making and using thereof

The disclosure provides a tetra-specific antibody monomer having a N-terminal and a C-terminal, comprising in tandem from the N-terminal to the C-terminal, a first scFv domain at the N-terminal, a Fab domain, a Fc domain, a second scFv domain, and a third scFv at the C-terminal, wherein the first scFv domain, the Fab domain, the second scFv domain, and the third scFv domain each has a binding specificity against a different antigen. In one embodiment, the antigen is a tumor antigen, an immune signaling antigen, or a combination thereof. Multi-specific antibodies comprising the disclosed tetra-specific antibodies are also provided.

MULTI-SPECIFIC ANTIBODIES AND METHODS OF MAKING AND USING THEREOF

The disclosure provides a tetra-specific antibody monomer having a N-terminal and a C-terminal, comprising in tandem from the N-terminal to the C-terminal, a first scFv domain at the N-terminal, a second scFv domain, a Fab domain, a Fc domain, and a third scFv at the C-terminal, wherein the first scFv domain, the second scFv domain, the Fab domain, and the third scFv domain each has a binding specificity against a different antigen. In one embodiment, the antigen is a tumor antigen, an immune signaling antigen, or a combination thereof. In one embodiment, the antigen includes CD19, CD3, CD137, 4-1BB, and PD-L1. Multi-specific antibodies comprising the disclosed tetra-specific antibodies are also provided.

Adjustable low-nitrogen flat flame combustor

The utility model provides an adjustable low-nitrogen flat flame combustor. The burner comprises an air distribution body, an air partition plate, an air distribution valve, a swirler, a burner block,a primary fuel gas spray pipe, a secondary fuel gas spray pipe and a fuel gas distribution valve, the partition plate is embedded into the air inlet pipe to divide the air inlet pipe into two air inlet channels, an original air channel is divided into primary air and secondary air, and the air distribution valve is fixedly connected to the end of the partition plate. And an air distribution valveis arranged at the air inlet pipe to divide the original fuel gas channel into primary fuel gas and secondary fuel gas, namely a primary fuel gas spray pipe and a secondary fuel gas spray pipe. An air distribution valve and a fuel gas distribution valve are arranged; according to the low-nitrogen flat-flame combustor, the mixing ratio and the mixing amount of primary air and primary fuel gas andthe ...

MULTI-SPECIFIC ANTIBODIES AND METHODS OF MAKING AND USING THEREOF

The disclosure provides a tetra-specific antibody monomer having a N-terminal and a C-terminal, comprising in tandem from the N-terminal to the C-terminal, a first scFv domain at the N-terminal, a Fab domain, a Fc domain, a second scFv domain, and a third scFv at the C-terminal, wherein the first scFv domain, the Fab domain, the second scFv domain, and the third scFv domain each has a binding specificity against a different antigen. In one embodiment, the antigen is a tumor antigen, an immune signaling antigen, or a combination thereof. Multi-specific antibodies comprising the disclosed tetra-specific antibodies are also provided.

Permanent magnet system for rotary magnetic refrigeration apparatus

The invention relates to a permanent magnet system used in rotary magnetic refrigerator, wherein, the stator comprises a hollow cylinder permanent magnet and a magnetic conductive polar shoe; the hollow cylinder magnet is assembled symmetry around the central axle of the section of magnet via even permanent magnets; the magnetic direction of permanent magnet is decided by Halbach rotation theory; the magnetic conductive polar shoes are formed by two metals with better magnetic conductivity, while one side face is engaged with the wall of the chamber of permanent magnet, while another side is arc; two magnetic conductive polar shoes are contacted on the wall of chamber at the center of N and S polarities, with 180 degree spatial difference. The rotor comprises a rotary axle, a magnetic conductive iron corn and a magnetic medium; the rotary is cylinder; the iron corn is made from magnetic conductive magnet, as the cylinder with central hole or with cut-off two edges, sheathing the rotary ...

Methods of making and using guidance and navigation control proteins

The application provides methods for generating a therapeutic composition. The method includes the steps of providing a cell material comprising a cytotoxic cell, incubating the cell material with a first GNC protein to provide an activated cell composition, wherein the activated cell composition comprises a first therapeutic cell, and formulating the activated cell composition to provide a therapeutic composition, wherein the therapeutic composition is substantially free of exogenous viral and non-viral DNA or RNA. The first GNC protein comprises a first cytotoxic binding moiety and a first cancer targeting moiety, wherein the first cytotoxic binding moiety has a specificity to a first cytotoxic cell receptor and is configured to activate the first cytotoxic cell, and wherein the first cancer targeting moiety has a specificity to a first cancer cell receptor. The first therapeutic cell comprises the first GNC protein bound to the cytotoxic cell through the first cytotoxic cell receptor ...

Disclosed is automatic braking system of torpedo car

The utility model provides an automatic braking system of a torpedo car. The torpedo tank car comprises wheels, wheel axles and side frames. The wheels are mounted at two ends of the wheel shaft; theside frames are arranged on the outer sides of the wheels; and the wheel is connected with a wheel axle, the automatic braking system is connected with the wheel axle; the device comprises a power transmission mechanism, a generator, a storage battery, a hydraulic pump and a brake disc. The power transmission mechanism is connected between the wheel axle and the generator; rotation motion of the wheel shaft serves as a power source of the generator, the generator is connected with the storage battery, generated electric energy is stored in the storage battery, the storage battery is connectedwith the hydraulic pump and provides electric energy for the hydraulic pump, the brake disc is arranged on the wheel and supported on the wheel shaft through the fixing frame, and the hydraulic pump is connected ...

GUIDANCE AND NAVIGATION CONTROL PROTEINS AND METHOD OF MAKING AND USING THEREOF

The application provides guidance and navigation control (GNC) proteins. In one embodiment, the guidance and navigation control (GNC) protein, comprising a binding domain for a T cell activating receptor, a binding domain for a tumor associated antigen, a bind domain for an immune checkpoint receptor, and a binding domain for a T cell co-stimulating receptor. The binding domain for the tumor associated antigen is not adjacent to the binding domain for the T cell co-stimulating receptor. In one embodiment, the binding domain for the T cell activating receptor is adjacent to the binding domain for the tumor associated antigen (TAA).

METHODS OF MAKING AND USING GUIDANCE AND NAVIGATION CONTROL PROTEINS

The application provides methods for generating a therapeutic composition. The method includes the steps of providing a cell material comprising a cytotoxic cell, incubating the cell material with a first GNC protein to provide an activated cell composition, wherein the activated cell composition comprises a first therapeutic cell, and formulating the activated cell composition to provide a therapeutic composition, wherein the therapeutic composition is substantially free of exogenous viral and non-viral DNA or RNA. The first GNC protein comprises a first cytotoxic binding moiety and a first cancer targeting moiety, wherein the first cytotoxic binding moiety has a specificity to a first cytotoxic cell receptor and is configured to activate the first cytotoxic cell, and wherein the first cancer targeting moiety has a specificity to a first cancer cell receptor. The first therapeutic cell comprises the first GNC protein bound to the cytotoxic cell through the first cytotoxic cell receptor ...

Depth camera rapid calibration method for three-dimensional reconstruction

The invention provides a depth camera rapid calibration method for three-dimensional reconstruction, so that problems of complicated operation, difficult adjustment, and poor universality of the existing depth camera calibration method for three-dimensional reconstruction can be solved. According to the provided simple and stable method, a calibration parameter of a camera can be obtained only by selecting any two points of a straight line passing through a center point of an image. For a pick-up head, the intrinsic parameters do not change with the change of the environment; and the intrinsic parameters of pick-up heads that are designed and produced in the same batch change little; and as long as the extrinsic parameter changes are obtained by calculation, the calibration process of the monitoring pick-up head can be considered as completed. For the monitoring camera, with the provided method, measurement can be directly carried out during the mounting process without the need to carry ...

Tartary buckwheat skin-whitening cream

The invention relates to tartary buckwheat skin-whitening cream. Each part of skin-whitening cream comprises tartary buckwheat, polyoxyethylene cetyl ether, glycerol monostearate, behenic alcohol, liquid paraffin, spermol octadecanoic acid ester, methyl polysiloxane, para-hydroxybenzoic acid, d-delta-EDTA salt, sodium hydroxide and distilled water. After facial cleansing, faces are uniformly spread with the whitening cream prepared and gently massaged till the whitening cream is completely absorbed. The cream can effectively whiten skin.

Paint additive

The invention relates to paint additive, composed of the following components by weight ratio: 10-12 parts of anti-yellowing resin, 8-10 parts of lavender, 8-10 parts of rosemary, 15-20 parts of mugwort leaf, 20-30 parts of butylation reactant of paracresol and dicyclopentadiene and 5-8 parts of polysiloxane. The paint additive made by mixing the components can be added in vegetable paint, can be antioxidant, prevent paint air bubble, prevent yellowing of the paint and cause the paint to be fragrant, and can cause mosquito to be far away from furniture or wall surface coated with the paint. Besides, the paint is pollution-free.

INTERLEUKIN-2 MUTEINS FOR THE EXPANSION OF T-REGULATORY CELLS

Provided herein are IL-2 muteins, IL-2 mutein Fc-fusion molecules, anti-IL-2 antibodies, and complexes comprising an anti IL-2 antibody bound to an IL-2 cytokine that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgG1 Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also provided herein are linker peptides that are glycosylated when expressed in mammalian cells. Also provided herein are methods of making and using the compositions of the present invention.

Intelligent caller management method

The invention discloses an intellectual accessor management method. The method comprises the following steps: an accessor enters the shooting zone of the image pickup device of an intellectual accessor system; the accessor inputs the information of an object to be accessed through an entry device; the picture pickup device of the system shoots the face of the accessor on the field automatically, and a first picture shot on the field is stored; the intellectual accessor system examines the valid certificate of the accessor and prompts through a speech device; the accessor scans and inputs the second picture and text messages on the valid certificate in an accessor database through a scanner; the object to be accessed is enquired according to the first picture and second picture through comparison; if the object passes the comparison and enquiry, access bills are printed, or else the object is listed on a blacklist; when the accessor leaves, cancellation information is input through a cancellation ...

Ecotypic reactive disperse dye and preparation method and application thereof

The invention relates to an ecotypic reactive disperse dye and a preparation method and application thereof. The dye is a product obtained by connecting the amino-group-containing disperse dye and the hydroxyl-containing disperse dye with amino terminated polyether or hydroxyl terminated polyether by taking a group, such as triazine ring, and the like, as a bridge group. The preparation method comprises the following steps of: connecting the amino terminated polyether or the hydroxyl terminated polyether with groups, such as s-triazine group, and the like; and then reacting the group with the disperse dye to obtain the ecotypic reactive disperse dye. The ecotypic reactive disperse dye can be taken not only as a reactive dye for dyeing a cotton fiber or a fabric, but also as the temporary soluble disperse dye for dyeing a polyester fiber or the fabric, and also as a dispersing agent for preparing a self-disperse dye. The ecotypic reactive disperse dye has the advantages of simple preparation ...

Power distribution network investment method based on reliability planning

A power distribution network investment method based on reliability planning includes the steps of determining a planning area, analyzing weak links of a power distribution network, setting reliability targets by comparing power supply zones, arranging planning projects according to the weak links of the power distribution network, calculating scheme reliability of the planning projects, judging whether the scheme reliability meets the set reliability targets or not, determining a scheme with the lowest unit investment, determining the planning projects and the like. The power distribution network investment method based on reliability planning has the advantages that the different reliability targets are set according to different zone characteristics, the projects of the power distribution network are arranged reasonably according to investment sensibility of different optimization measures of the weak links of the power distribution network, the investment orientation is controlled, ...

Interleukin-2 muteins for the expansion of T-regulatory cells

Provided herein are IL-2 muteins, IL-2 mutein Fc-fusion molecules, anti-IL-2 antibodies, and complexes comprising an anti IL-2 antibody bound to an IL-2 cytokine that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgGI Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also provided herein are linker peptides that are glycosylated when expressed in mammalian cells. Also provided herein are methods of making and using the compositions of the present invention.

Epoxy resin modified material with three-layer structure and preparation method thereof

The invention belongs to the technical field of epoxy resin modified materials, and in particular relates to an epoxy resin modified material with a three-layer structure and a preparation method thereof. Under normal pressure, epoxy resin is reacted with a curing agent at certain temperature for a period of time; an interlayer of the three-layer structure after the material curing consists of a bicontinuous structure formed by a modifying agent and condensate obtained after the reaction of the epoxy resin and the curing agent; the weight percent of the condensate in the interlayer accounts for 6 to 40 percent of the total weight of the modified material, and the weight percent of the modifying agent accounts for 10 to 18 percent of the total weight of the modified material; the size between phase areas of the bicontinuous structure formed by the condensate and the modifying agent is between 1 and 20 micrometers; and two outer layers respectively consist of 0.2-5 micrometer particles formed ...

Device is searched for andd rescue to wireless direction -finding location

The utility model provides a device is searched for andd rescue to wireless direction -finding location, include signal processing module and connect respectively signal processing module's direction -finder antenna module, man -machine interaction module, communication module, power, personnel position in danger can be confirmed to the direction -finder antenna module, signal processing module reaches the definite personnel's in danger of location principle of time position coordinate based on the signal, man -machine interaction module can the intuitively shows personnel's in danger azimuth -range. The utility model discloses a device is searched for andd rescue to wireless direction -finding location can receive personnel's in danger distress signal immediately to the position of indicateing out personnel in danger realizes because of with a varied topography directly perceivedly, the mesh beyond one's ability or by the barrier shelter from, personnel's in danger under the abominable ...

METHODS OF MAKING AND USING GUIDANCE AND NAVIGATION CONTROL PROTEINS

Heat exchange system of permanent magnetism rotary type magnetic refrigerating machine

The invention relates to a heat conversion system of a permanent-magnet rotation magnetic refrigerator comprising a fluid channel in a magnetic refrigerant region, diversion trenches, a rotation-stillness pipe connector, a hot end heat converter, a cold end heat converter, a fluid pump and a diversion pipe. One sides of the two division trenches are respectively positioned on two axial end surfaces at two sides of the rotor magnetic refrigerant region and are fixed with the magnetic refrigerant region to rotate with a rotor. The other sides of the two division trenches are respectively connected to the diversion pipe on the rotor, the diversion pipe is connected to the hot end heat converter, the cold end heat converter and a fluid pump through the rotation-stillness pipe connector to form a fluid loop which is charged with heat conversion fluid. The shape of the axial end surface of the division trench near to the magnetic refrigerant region is same to the shape of the magnetic refrigerant ...

User traffic prediction method and device, computer equipment and storage medium

The invention relates to a user traffic prediction method and device, computer equipment and a storage medium. Relates to the technical field of artificial intelligence. The method comprises the steps of obtaining influence factor data of multiple categories; the influence factor data is data corresponding to the influence factors of the user traffic in the historical time period; in the influence factor data of each category, screening target influence factor data of a target category, and adjusting initial user traffic prediction networks corresponding to the influence factor data except the target influence factor data to obtain a user traffic prediction network corresponding to each influence factor data; for the influence factor data of each category, predicting user traffic data of a target time period corresponding to the influence factor data of the category according to a user traffic prediction network corresponding to the influence factor data of the category; and determining ...

A waterproof material based on flexible polymer modification cement and its preparation method

A waterproof material based on flexible polymer modification cement and its preparation method

Method for preparation of monodisperse phase-change microcapsule

The invention relates to a phase transition microcapsule, in particular to a preparation method of a monodisperse phase transition microcapsule with controllable size and surface shape and appearance and the microcapsule obtained by the preparation method thereof. The microcapsule is prepared by covering organic capsule cores that have a phase transition function through a heat-resistant polymer capsule wall. First, certain amount of capsule core materials are added into water to be emulsified and dispersed, water soluble polymer capsule wall prepolymer is added and the temperature is continued to be raised; pH value of the solution is adjusted to 3.5-5.5 by dripping acidizing fluid slowly; reacted and cured products are filtered, cleaned and dried repeatedly and finally the monodisperse phase transition microcapsule with controllable size and surface shape and appearance is obtained. The phase transition microcapsule produced by the invention has stable performance, controllable sizeand ...

Multi-specific antibodies and methods of making and using thereof

The disclosure provides a tetra-specific antibody monomer having a N-terminal and a C-terminal, comprising in tandem from the N-terminal to the C-terminal, a first scFv domain at the N-terminal, a second scFv domain, a Fab domain, a Fc domain, and a third scFv at the C-terminal, wherein the first scFv domain, the second scFv domain, the Fab domain, and the third scFv domain each has a binding specificity against a different antigen. In one embodiment, the antigen is a tumor antigen, an immune signaling antigen, or a combination thereof. In one embodiment, the antigen includes CD19, CD3, CD137, 4-1BB, and PD-L1. Multi-specific antibodies comprising the disclosed tetra-specific antibodies are also provided.

Sintering kiln temperature-measuring thermocouple protection device

The invention relates to a sintering kiln temperature-measuring thermocouple protection device which comprises a sintering kiln, wherein a temperature-measuring thermocouple is arranged on the inner kiln wall of the sintering kiln, a protection device body is arranged around the temperature-measuring thermocouple and is formed by refractory bricks arranged on the left side and right side of the temperature-measuring thermocouple and above the temperature-measuring thermocouple. The sintering kiln temperature-measuring thermocouple protection device is ingenious in concept, and the temperature-measuring thermocouple can be protected against breakage and bumping damage by a dropped-out ceramic roller bar only by building several refractory bricks around the temperature-measuring thermocouple during kiln wall construction. Several refractory bricks are increased, the manufacturing cost is almost not increased, the replacement and maintenance frequency of the temperature-measuring thermocouple ...

GUIDANCE AND NAVIGATION CONTROL PROTEINS AND METHOD OF MAKING AND USING THEREOF

Damped system of permanent magnetic gear

The invention discloses a damped system of a permanent magnetic gear, which consists of an electric metal material layer fixed on a magnetic pole surface between a driving gear and a driven gear. The metal material layer is wholly or partly covered on the magnetic pole surfaces of the driving gear and the driven gear. For instance: for the externally meshed permanent magnetic gear, the metal material layer is respectively fixed at the surface of a cylinder or a ring body of the driving gear and the driven gear. For the internally meshed permanent magnetic gear, the metal material layer is respectively fixed at the inner surface of the ring body of the outer gear and the surface of a cylinder of a ring of an inner gear. For transmission between the permanent magnetic gear and a permanent magnetic gear rack, the metal material layer is respectively fixed at the surface of a cylinder or a ring body of the permanent magnetic gear and on the plane of one side of the permanent magnetic gear rack ...

Bispecific antibodies and methods of making and using thereof

The disclosure provides bispecific antibodies having the binding specificity to at least two of human CTLA4, PD-1 or PD-L1. In one embodiment, the bispecific antibody comprises IgG domains having heavy chains and light chains, and two scFv components being connected to either C-terminal of the heavy chains or N-terminal of the light chains, wherein the IgG domains have the binding specificity to a first antigen, wherein the scFv components have the binding specificity to a second antigen, and wherein the first antigen and the second antigen are different and are independently selected from [alpha]-CTLA4, [alpha]-PD-1, and [alpha]-PD-L1.

Composite premix for reducing nitrogen pollution in pig raising industry and preparation method thereof

The invention relates to a composite premix for reducing nitrogen pollution in the pig raising industry and a preparation method thereof. The composite premix comprises the following components in part by weight: 3 to 5 parts of L-isoleucine, 3 to 5 parts of L-lysine hydrochloride, 8 to 10 parts of DL-methionine, 3 to 5 parts of L-threonine, 3 to 5 parts of L-valine, 3 to 5 parts of DL-tryptophan and 65 to 75 parts of carrier; and the method comprises the following steps of: mixing and screening all amino acids and 1/4 weight carrier, adding the rest carrier, and uniformly mixing the components for 10 to 15 minutes to obtain a product. Compared with the prior art, the composite premix can reduce the protein in daily ration of piglets by 3 to 4 percent, reduce the nitrogen content of the piglet excrement by 25 to 35 percent and improve the survival rate of the piglets, is simple and convenient to use, and is easily used by various farms and feed factories.

Drainage facility for elevated bridge

The invention discloses a drainage facility for an elevated bridge. The drainage facility for the elevated bridge consists of a sedimentation basin, a cement cover plate, a drain pipe, a three-way pipe, an elbow and a service valve which are arranged on a bridge floor. According to the drainage facility for the elevated bridge, disclosed by the invention, sedimentation treatment can be performed on accumulated water on the bridge floor through the sedimentation basin, so that the drain pipe cannot be blocked by silt during drainage, and the interior of the pipeline can be cleared at regular intervals to ensure the drainage to be smooth.

Methods of making and using guidance and navigation control proteins

The application provides method of treating a subject having a cancer using a guidance and navigation control (GNC) protein. In one embodiment, the method includes the steps of providing a blood from the subject, isolating peripheral blood mononuclear cells (PBMC) from the blood, isolating a cytotoxic cell from the PBMC, combining a GNC protein with the cytotoxic cell to provide a therapeutic cell, optionally expanding the therapeutic cell to provide an expanded cell population, and administering the therapeutic cell or the expanded cell population to the subject. In one embodiment, the GNC protein may be a bi-specific, tri-specific, or tetra-specific antibody.

ULTRA WIDE BAND DIGITAL PHASE SHIFTER

The present invention discloses an ultra wide band digital phase shifter, wherein the phase shifter includes a coupler, a first impedance network and a second impedance network. The coupler is cascaded by spiral inductor coupling units; each stage of spiral inductive coupling unit includes a first spiral inductor and a second spiral inductor coupled mutually; multistage cascade of the spiral inductor coupling units is implemented through the series connection of each stage of first spiral inductors and the series connection of each stage of second spiral inductors; and the coupling interval or microstrip band width of each stage of spiral inductor coupling unit in the coupler from the exterior to the interior decreases gradually. The impedance networks are implemented using LC circuits and switching elements, and the states of the impedance networks are switched by a switch, thus producing phase displacement; therefore, the impedance network is rational in structure and is easy to implement; the phase shifter has the advantages of compact structure, small area occupation and good wideband character and has larger advantages and application space in integrated chip applications. 1. An ultra wide band digital phase shifter , comprising a coupler , a first impedance network and a second impedance network , wherein:the coupler is cascaded by spiral inductor coupling units; each stage of spiral inductive coupling unit includes a first spiral inductor and a second spiral inductor coupled mutually; multistage cascade of the spiral inductor coupling units is implemented through the series connection of each stage of first spiral inductor and the series connection of each stage of second spiral inductor;one end of the first spiral inductor in the first stage of spiral inductor coupling unit cascaded in the coupler and located outside is an input end of the coupler, and also serves as an input end of the phase shifter, and one end of the second spiral inductor located outside ...

Permanent magnetism body system for rotary magnetic refrigeration

The invention relates to a rotary magnetic refrigeration permanent magnet system. A stator is a hollow cylindrical permanent magnet based on the Halbach rotation principle. The hollow cylindrical magnet is formed by assembling permanent magnetic blocks with the central shaft on the cross section of the magnet. The magnetizing directions of the permanent magnetic blocks are determined by the Halbach rotation principle. A rotor mainly comprises magnetic conductive iron cores, a magnetic working substance and a rotating shaft. A rotator shaft is positioned in the central rotation position of the rotor. The central lines of two sections of rotator shaft are overlapped with the geometric center line of the rotor. Two magnetic conductive iron cores of the rotor are cylindrical bodies with bow-shaped cross sections, connected with the rotating shaft as a whole through a connection bracket and sleeved on the rotating shaft. The magnetic working substance is tightly fixed between the two magnetic ...

Minisize tension meter for infrared spectrometer

The present invention relates to a mini-type extensograph on infrared spectrometer to process infrared red spectroscopic analysis of fibre material and film material in different temperature and different tensional state. Heating chamber in which has high temperature resistance linear guide and sample clamp, linear guide with linear displacement digital ruler are mounted on the base, and a constant velocity bidirectional tension mechanism with push pull rod connected with sample clamp seat and through the heating chamber, and bidirectional screw through the bottom of constant velocity bidirectional tension mechanism and inosculated with snail button of fixation block fixed on the bottom of two soleplates of constant velocity bidirectional tension mechanism are mounted on the linear guide. The bidirectional screw is connected with rapid motion mechanism and shaft sleeve of reducer to realize tension the sample in the conditions of heating, heat preservation-constant temperature under the ...

Permanent magnetism magnetic body system for rotating magnetic refrigerating device

The present invention provides a permanent magnetism magnetic body system for a rotating magnetic refractor. The permanent magnetism magnetic body of a stator is made up of two permanent magnetism blocks with 180 degree phase difference in spatial position, charging magnetism direction of two permanent magnetism blocks is same, and is along the radial direction of stator. Guide magnet yoke of stator is hollow circular cylinder shaped, and is made up of magnetic conduction metallic material; two permanent magnetism blocks is fixed on the inner wall of guide magnet yoke; a circular arc shaped of permanent magnetism blocks is identical with the inner wall of guide magnet yoke, another crown face is concentric with inner wall of guide magnet yoke. Centre point of the rotor is superposition with geometric centre point of stator guide magnet yoke. Rotor guide magnet heart is a cylinder with centre hole or a cylinder scraping both sides, and is mounted on rotor shaft. Magnetic working substance ...

Permanent magnet system for rotary magnetic refrigeration apparatus

Sampling equipment for highway geological survey

The invention relates to the technical field of sampling equipment, and discloses highway geological survey sampling equipment which comprises a connecting cylinder with the side face fixedly connected with supporting legs, the bottoms of the supporting legs are fixedly connected with a bottom plate used for supporting, the lower surface of the bottom plate is tightly attached to the ground, and the supporting legs are fixed; the inner wall of the connecting cylinder is in threaded connection with a movable cylinder used for connection, and the side face of the bottom of the movable cylinder is fixedly connected with a drilling disc used for drilling soil. According to the highway geological survey sampling equipment, through combined arrangement of the supporting legs, the connecting cylinder, the bottom plate, the movable cylinder and the drilling disc, a worker can conveniently drill a hard surface layer on the soil surface, so that the worker can conveniently collect soil in the soil ...

Method for recognizing human face

The invention discloses a method of face recognition. Firstly, known and classified face samples are trained for modeling via pairs of training modules to produce a support vector machine classifier capable of classifying and recognizing unknown face samples, then, features of the unknown face samples are extracted via recognition modules, and to-be-recognized recognition samples after being extracted out features are transferred to a trained support vector machine classifier to judge the faces which category belong to. The invention provides the method of face recognition based on nuclear stochastic mapping and support vector machines, and the method of nuclear stochastic mapping is initially used for extracting more effective face features in the process of extraction of the face features. In addition, the support vector machine classifier used for dichotomy classification is employed in the problem of face multiple classification, a pair of multi-strategies are employed to convert multi-problems ...

Android bus inquiry system and method based on Compass real-time positioning information

An Android bus inquiry system based on Compass real-time positioning information comprises Compass satellites, a vehicle-mounted Compass positioning sub-system, a bus position information collecting and processing system and a user terminal. The Android bus inquiry system and method based on Compass real-time positioning information achieve the interaction between urban bus running information and a user, enable a user to obtain the running dynamic information of a bus in real time, improve the going-out efficiency of people, shorten the bus-waiting time, improve the comfort of bus traveling, improve the recognition degree on bus traveling of the user, relieve the pressure of traffic jam, and facilitate guidance of urban traffic. In addition, after the user obtains the bus real-time information, the user can reasonably select a traveling transportation means. If buses replace cars, tail gas exhaust can be largely reduced, the haze weather is improved to a large extent, and the 'environmentally ...

Graphite cast iron, use thereof and rolling method of carbon steel rail

The invention relates to a graphite cast iron, a use thereof and a rolling method of a carbon steel rail, belonging to the metallurgy field. The invention aims at providing a graphite cast iron, and rolls made from the graphite cast iron can prevent occurrence of pasting steel. The graphite cast iron comprises the following chemical components by weight percent: 1.0-2.3 percent of C, 1.2-2.0 percent of Si, 0.3-1.0 percent of Mn, less than or equal to 0.35 percent of P, less than or equal to 0.35 percent of S, less than or equal to 1.8 percent of Cr, less than or equal to 0.8 percent of Mo, less than or equal to 3.0 percent of Ni and the balance of Fe and unavoidable impurity. In the graphite cast iron, the rolls can prevent occurrence of pasting steel to avoid backfin on the surface of the steel rail by adding chemical components by special proportion.

Power system carbon flow analysis method, device and equipment containing distributed power supply access and storage medium

The invention discloses a carbon flow analysis method, a carbon flow analysis device and carbon flow analysis equipment for a power system with distributed power supply access, and a storage medium, and the method comprises the steps: taking a carbon flow analysis method of a conventional power system as a basis, and enabling a distributed power supply to be equivalent to a generator node; the problem that matrix elements are abnormal when the output of the distributed power supply is zero and no other branch injects forward active power to the node where the branch is located in the carbon flow calculation is solved by utilizing a continuous number setting method, so that the power system accessed by the output of the distributed power supply can normally and accurately perform carbon flow calculation.

Method for recognizing human face

The invention discloses a method of face recognition. Firstly, known and classified face samples are trained for modeling via pairs of training modules to produce a support vector machine classifier capable of classifying and recognizing unknown face samples, then, features of the unknown face samples are extracted via recognition modules, and to-be-recognized recognition samples after being extracted out features are transferred to a trained support vector machine classifier to judge the faces which category belong to. The invention provides the method of face recognition based on nuclear stochastic mapping and support vector machines, and the method of nuclear stochastic mapping is initially used for extracting more effective face features in the process of extraction of the face features. In addition, the support vector machine classifier used for dichotomy classification is employed in the problem of face multiple classification, a pair of multi-strategies are employed to convert multi-problems ...

Initiative appointment-making type intelligent elevator dispatching system

The invention relates to an initiative appointment-making type intelligent elevator dispatching system. The initiative appointment-making type intelligent elevator dispatching system comprises a mobile phone client terminal, a dispatching total server, a local intelligent elevator dispatching server and an elevator controller, wherein the mobile phone client terminal is used for collecting and transmitting user elevator taking information; the dispatching total server is connected with the mobile phone client terminal in a wireless communication mode, receives and distributes the user elevator taking information transmitted by the mobile phone client terminal, and meanwhile transmits feedback information to the mobile phone client terminal; the local intelligent elevator dispatching server is connected with the dispatching total server in a wireless communication mode or a wired internet mode, receives the user elevator taking information distributed through the dispatching total server ...

Bacillus coagulans, preparation of high-density cultivated spore preparation, and use thereof

The present invention discloses a preparation method and application of Bacillus coagulans and a spore preparation cultured in high density, and belongs to the microbe technical field. A Bacillus coagulans strain is classified and named Bacillus coagulans JSSW-LA-07 and is preserved as CGMCC No.2602 in China General Microbiological Culture Collection Center. The Bacillus coagulans strain JSSW-LA-07 can produce spore under an aerobic condition and produce a small amount of L-lactic acid in the metabolism during a course of fermentation. The Bacillus coagulans strain can produce L-lactic acid with a higher purity under an anaerobic condition. The strain does not produce substances which can be harmful to human and cultured animals, has the characteristics of innocuity, on residue, no side effect and the like, has a great significance for production of green and safe livestock, fowls and marine products and improvement of cultivation ecological environment, and can be widely applied in the ...

Distributed power supply-containing main and distribution cooperative reactive voltage optimization scheduling method and distributed power supply-containing main and distribution cooperative reactive voltage optimization scheduling system

The invention discloses a distributed power supply-containing main and distribution cooperative reactive voltage optimization scheduling method and system, and the method comprises the steps: carrying out the disassembly of a main and distribution network reactive optimization problem when the reactive voltage optimization scheduling of a power system is realized, and solving a main network reactive voltage problem and a distribution network reactive voltage problem respectively; and a main network reactive power optimization problem is solved by adopting a branch and bound-positive semidefinite programming method, a distribution network reactive power optimization problem is simplified and solved by adopting a quadratic constraint linearization method, and finally verification is performed through a boundary constraint problem. According to the invention, a more effective scheduling method is provided for improving the voltage of each load node, reducing the reactive power loss of the ...

Ultra wide band digital phase shifter

The present invention discloses an ultra wide band digital phase shifter, wherein the phase shifter includes a coupler, a first impedance network and a second impedance network. The coupler is cascaded by spiral inductor coupling units; each stage of spiral inductive coupling unit includes a first spiral inductor and a second spiral inductor coupled mutually; multistage cascade of the spiral inductor coupling units is implemented through the series connection of each stage of first spiral inductors and the series connection of each stage of second spiral inductors; and the coupling interval or microstrip band width of each stage of spiral inductor coupling unit in the coupler from the exterior to the interior decreases gradually. The impedance networks are implemented using LC circuits and switching elements, and the states of the impedance networks are switched by a switch, thus producing phase displacement; therefore, the impedance network is rational in structure and is easy to implement ...

Water-lubricated ship stern bearing capable of realizing automatic load balancing

The invention discloses a water-lubricated ship stern bearing capable of realizing automatic load balancing. The stern bearing comprises an inner rubber layer, a first metal shaft sleeve layer, a second metal shaft sleeve layer, a self-adaptive material layer and a third metal shaft sleeve layer from inside to outside in sequence, wherein the self-adaptive material layer is distributed between the second and third metal shaft sleeve layers; the thickness of the self-adaptive material layer changes in a gradient manner along the axial direction of the stern bearing; the stern bearing is adaptively cured and formed with the oblique degree of a ship stern shaft. The invention further discloses the materials and embodiments of work specifications of the self-adaptive material layer, the metal shaft sleeve layers and the inner rubber layer. According to the water-lubricated ship stern bearing capable of realizing automatic load balancing, the rubber layer at the inner side of the water-lubricated ...

Method for restoring side slope ecology by adopting AB (Acinetobacter baumannii) bacterium plant growing bags

The invention relates to a method for restoring side slope ecology by adopting AB(Acinetobacter baumannii) bacterium plant growing bags, comprising the following steps of: placing substrates and seeds in plant growing bags sewn by adopting non-woven fabrics, obliquely palletizing the planting bags on a side slope by layers, and then curing for 30 days to accomplish side slope restoration. In the method, the AB bacterium plant growing bags are used as main materials for side slope restoration, thereby being beneficial to the activation and the long-term effectiveness of nutrients in the substrates; meanwhile, the quantity of microorganisms can be increased, and the microorganisms are used for decomposing organic matters and releasing mineral elements, thereby increasing the fertility of soil and being beneficial to the growth of greening plants on the side slope. The palletizing mode of the plant growing bags is beneficial to the utilization of moistures and simultaneously provides plastically ...

Guidance and navigation control proteins and method of making and using thereof

The application provides guidance and navigation control (GNC) proteins. In one embodiment, the guidance and navigation control (GNC) protein, comprising a binding domain for a T cell activating receptor, a binding domain for a tumor associated antigen, a bind domain for an immune checkpoint receptor, and a binding domain for a T cell co-stimulating receptor. The binding domain for the tumor associated antigen is not adjacent to the binding domain for the T cell co-stimulating receptor. In one embodiment, the binding domain for the T cell activating receptor is adjacent to the binding domain for the tumor associated antigen (TAA).

Therapy device for inactivating pathogenic microorganisms in in-vivo blood by photodynamic therapy

The invention discloses a therapy device for inactivating pathogenic microorganisms in in-vivo blood by photodynamic therapy. The device comprises a laser light source, a driving power source, an irradiation cabin and a photosensitizer pump, wherein the driving power source is arranged in a shell for providing electric energy for the therapy device; the irradiation cabin is connected with an extracorporeal circulation channel; the photosensitizer pump is connected with the irradiation cabin; a control panel for controlling the photosensitizer pump and the power density of the laser light source is also arranged in the shell; a fluorescent detector is connected between the control panel and the irradiation cabin; a light source control circuit is connected between the control panel and the laser light source; and the front side face of the shell is provided with an operating panel which is connected with the control panel and the driving power source. Through the therapy device for inactivating ...

Distributed power generation cluster division method based on improved K-means algorithm

The invention discloses a distributed power generation cluster division method based on an improved K-means algorithm. The method comprises the following steps: quantifying the reasonability of a cluster scale by adopting node membership indexes; combining an electrical modularity index, an active power balance index, a reactive power balance index and a node membership index to establish a comprehensive cluster division index system; determining an optimal clustering number k of a K-means algorithm by adopting a distance cost function method; providing a grey wolf algorithm based on Levy flight optimization, and optimizing an initial clustering center; and according to the optimal initial clustering center output by the improved grey wolf algorithm, a comprehensive cluster division index is used as a fitness function of the improved grey wolf algorithm, and a K-means algorithm is used to complete cluster division. By considering the size of the cluster scale, the size of the cluster scale ...

Lithospermum cream for men

The invention relates to a lithospermum cream for men, containing beeswax, stearic acid, stearyl alcohol, glycerol, propylene glycol, olive oil, lecithin, stearic monomethyl ester, cocoa butter, wool oil, lithospermum, antiseptic, lavender essence and deionized water. After a face is cleaned, the prepared cream is applied onto the face. The lithospermum cream has the antibacterial effect and the anti inflammatory effect, can accelerate the growth rate of epithelium, has good curative effect on plane warts, dermatitis and acnes of young people, can diminish inflammation, kill bacteria and moisten skin and has forest smell.

Sports football cleaning machine

The invention discloses a sports football cleaning machine which comprises a box body, a first conveying part and a second conveying part, a ball feeding barrel is rotationally connected to the top end of the box body and communicates with a ball inlet formed in the top end of the box body, the first conveying part comprises a first transmission rod connected into the box body in a sliding mode, the first transmission rod is in transmission connection with the ball feeding barrel, and a fixing piece is arranged at the top end of the first transmission rod; the fixing piece blocks the ball inlet through the first transmission rod, and a cleaning assembly is arranged in the box body and corresponds to the fixing piece. The second conveying part comprises a second transmission rod which is in transmission connection with the first transmission rod, a clamping piece is arranged on the second transmission rod, the clamping piece and the fixing piece move oppositely or oppositely, and when the ...

Damped system of permanent magnetic gear

The invention discloses a damped system of a permanent magnetic gear, which consists of an electric metal material layer fixed on a magnetic pole surface between a driving gear and a driven gear. The metal material layer is wholly or partly covered on the magnetic pole surfaces of the driving gear and the driven gear. For instance: for the externally meshed permanent magnetic gear, the metal material layer is respectively fixed at the surface of a cylinder or a ring body of the driving gear and the driven gear. For the internally meshed permanent magnetic gear, the metal material layer is respectively fixed at the inner surface of the ring body of the outer gear and the surface of a cylinder of a ring of an inner gear. For transmission between the permanent magnetic gear and a permanent magnetic gear rack, the metal material layer is respectively fixed at the surface of a cylinder or a ring body of the permanent magnetic gear and on the plane of one side of the permanent magnetic gearrack ...

Method and system for detecting SF6 gas decomposition characteristic products

The invention discloses a method and a system for detecting SF6 gas decomposition characteristic products. The method comprises the following steps: collecting SF6 and the decomposition characteristic products SO2 and SOF2 from a GIS system, and purifying the collected gas; purified gas enters a high-performance detection device according to a set flow rate, the high-performance detection device raises a high-performance sensing chip to a detection temperature through a chip temperature control module, and active substances TiO2 and SnO2 in the high-performance sensing chip adsorb SO2 and SOF2 gas; chip current signals in the gas adsorption process are collected and amplified, and SO2 and SOF2 gas concentration detection results are obtained and displayed in combination with the pre-calibrated current and concentration relation; and if the SO2 and SOF2 gas concentration detection result meets the concentration requirement, refilling the gas into the GIS system, or else, giving an alarm.

Calibration correcting method for ultraviolet radiation meter

The invention discloses a calibration correcting method for an ultraviolet radiation meter. The calibration correcting method comprises the steps that the real ultraviolet irradiance reaching the ground at a point is expressed as F(lambda), the ultraviolet irradiance output by a model is expressed as F[m] (lambda), and then the formula F(lambda)=F[m] (lambda) is obtained; the ultraviolet irradiance observed by an aged ultraviolet radiation meter is expressed as F[ab] (lambda), and then attenuation rate can be expressed as the formula D=1- , and the attenuation rate D is a function related to time, namely, D=F(t), wherein D is the monthly attenuation rate, t is the number of service months of the meter; 85 fine cloudless days are selected, and the ultraviolet irradiances of 106 time points are adopted; the time series of D is obtained according to the formula, the attenuation rate of all the months are averaged, so that the monthly average attenuation rate D[mean] is obtained, fitting is ...

Bionic artificial heart blood pump linearly driven by permanent magnetic field in vitro

The invention discloses a bionic artificial heart blood pump linearly driven by a permanent magnetic field in vitro. The blood pump consists of an active magnet, a passive magnet, a pump body, a piston and a check valve, wherein the active magnet is positioned in vitro; the passive magnet, the pump body and the piston are positioned in vivo, and the passive magnet and the piston are combined intoa whole; and the passive magnet and the piston are sealed in a shell of the blood pump to separate the space in the shell into a first space (1) and a second space (2). The shell is fixed in a thoracic cavity of a human body. An electric motor positioned in vitro drives the active magnet to perform reciprocating linear motion, a magnetic field generated by the active magnet also begins to performthe reciprocating linear motion, and the passive magnet positioned in vivo performs the same reciprocating linear motion with the active magnet under the action of the magnetic field and drives the piston ...

Bridge driving early warning method and device, electronic equipment and medium

The invention provides a bridge driving early warning method and device, electronic equipment and a medium, and the method comprises the steps: obtaining the vehicle information and bridge weather information of a target vehicle according to bridge driving early warning; performing safety prediction on the target vehicle according to the vehicle information and the bridge weather information to obtain a prediction result, the safety prediction including at least one of wind speed, sideslip, visibility, temperature and humidity; and carrying out early warning on the target vehicle according to the prediction result. The beneficial effects of the invention are that monitoring, forecasting and early warning are carried out on various meteorological elements according to actual conditions and forecast conditions for bridge traffic safety, and real-time data and current effective early warning are fed back to users. According to the invention, the service product with the corresponding parameter ...

Commutator reinforcing ring crack detector and application device and detection method thereof

The invention relates to a commutator reinforcing ring crack detector, which comprises an oscillating circuit, the oscillating circuit comprises a potentiometer wp and an adjustable capacitor C12, the oscillating circuit is connected with an electromagnetic sensor, the electromagnetic sensor comprises a coil X1 and a coil X2, and the oscillating circuit is used for outputting alternating current to the coil X1 and the coil X2 and attenuating with a reverse electromotive force generated by a reinforcing ring; the amplifying circuit is used for amplifying the alternating current signal; the precise linear rectifying circuit is used for converting the alternating current signal into a direct current signal; the control module comprises a controller and a plurality of MCU units connected with the controller; an external interaction module; wherein the oscillating circuit, the amplifying circuit and the precise linear rectifying circuit form an electromagnetic sensing circuit, and the external ...

Longitudinal stress transfer test platform for disassembly and assembly of shield segment

The invention provides a longitudinal stress transfer test platform for disassembly and assembly of shield segments. Comprising a front baffle plate, a rear baffle plate, a bottom base, four threaded connecting rods, an overlying structure, a loading heavy block, a first rubber gasket, a second rubber gasket, a loading device, a first movable force transmission baffle plate, a second movable force transmission baffle plate, a first extractable duct piece baffle plate and a second extractable duct piece baffle plate, a first overlying structure baffle and a second overlying structure baffle. The test platform is mainly used for obtaining the longitudinal mechanical behavior characteristics in the shield segment assembling and disassembling process. The research on the mechanical behavior characteristics of the duct piece is beneficial to optimization of the structural design of the duct piece tunnel, and has important guiding significance on shield assembly control.

Power grid company carbon emission reduction path risk measurement method

The invention relates to a power grid company carbon emission reduction path risk measurement method comprising the following steps: determining a power grid company carbon emission reduction path, the carbon emission reduction path comprising a direct emission reduction path and an indirect emission reduction path; constructing a power grid enterprise carbon emission reduction path risk measurement index system according to the power grid enterprise carbon emission reduction path; according to the power grid enterprise carbon emission reduction path risk measurement index system, determining a power grid enterprise carbon emission reduction path risk measurement index weight based on a fuzzy BWM method; according to the power grid enterprise carbon emission reduction path risk measurement index weight, the risk degree of various power grid enterprise carbon emission reduction paths is measured based on a fuzzy TOPSIS method; the method can improve the carbon emission reduction risk management ...

Sandy ecological slope protection base material based on EICP technology and high-calcium fly ash and use method

According to the sandy ecological slope protection base material based on the EICP technology and the high-calcium fly ash and the using method, the high-calcium fly ash serves as a calcium source in the EICP technology, and resource utilization of the high-calcium fly ash is fully achieved; the problem of poor stability is overcome, sufficient growth time is provided for plants in a sandy ecological slope protection base material by utilizing the characteristic of slow coagulation speed, and sufficient hydration time is provided for high-calcium fly ash while the application difficulty is reduced by adopting the principle of separate application of a calcium source urea-urease solution. Calcium ions are fully separated out and are combined with a urea-urease solution, so that the crystallization and slope protection effects are enhanced. According to the method, ammonium ions generated by hydrolyzing urea through urease are combined with the habitat base material modifier for use, the ...

Ultra wide band fixed phase shifter based on capacitive load and having N physically separated phase shift units with orthocouplers therein

The present invention discloses an ultra wide band fixed phase shifter based on a capacitive load, which includes N physically separated phase shift units, and each phase shift unit includes an orthocoupler, first and second transmission lines, and first and second capacitive loads, wherein the orthocoupler includes an input end, a coupling end, a direct-connection end and an isolation end, one end of the first transmission line serves as a signal input end of the phase shift unit and the other end is connected with the input end of the orthocoupler, one end of the second transmission line serves as a signal output end of the phase shift unit and the other end is connected with the isolation end of the orthocoupler; one end of the first capacitive load is connected with the coupling end of the orthocoupler and the other end is grounded; one end of the second capacitive load is connected with the direct-connection end of the orthocoupler and the other end is grounded. The ultra wide band ...

Method for analyzing weak links of power distribution network status

The invention provides a method for analyzing weak links of the power distribution network status. The method includes the steps of analyzing characteristics of a regional power distribution network, establishing a power distribution network status weak link analysis index system, collecting power distribution network status data corresponding to all indexes in the analysis index system, checking and analyzing the power distribution network status data in the analysis index system item by item so as to find out the weak links of the power distribution network status and other steps. The method has the advantages that when the weak links of the power distribution network status are analyzed, the single problem of existence of the power distribution network is considered, and the integrality and the sustainable development of the power distribution network are considered simultaneously, so the analysis method is more scientific and comprehensive; the method provides a beneficial reference ...

External magnetic field driving system of permanent magnet used for artificial heart

The invention relates to an external magnetic field driving system of a permanent magnet used for an artificial heart. In the invention, a driving magnet is positioned outside a human body; a first driven magnet and a second driven magnet are positioned inside the human body; the driving magnet is closed in an immovable casing and is driven by a motor to rotate; the first driven magnet is positioned between the driving magnet and the second driven magnet, and the rotation center line of the first driven magnet is parallel to the rotation center lines of the driving magnet and the second driven magnet; the first driven magnet is closed in an immovable casing, and the casing is fixed in the thorax of the human body; the second driven magnet is positioned in the ascending aorta of the heart, and the rotation center line of the second driven magnet is parallel to that of the first driven magnet; and the second driven magnet and an impeller of a blood pump are connected together.

GUIDANCE AND NAVIGATION CONTROL PROTEINS AND METHOD OF MAKING AND USING THEREOF

The application provides guidance and navigation control (GNC) proteins. In one embodiment, the guidance and navigation control (GNC) protein, comprising a binding domain for a T cell activating receptor, a binding domain for a tumor associated antigen, a bind domain for an immune checkpoint receptor, and a binding domain for a T cell co-stimulating receptor. The binding domain for the tumor associated antigen is not adjacent to the binding domain for the T cell co-stimulating receptor. In one embodiment, the binding domain for the T cell activating receptor is adjacent to the binding domain for the tumor associated antigen (TAA).

Lithium cobaltate composite positive pole material and preparation, secondary lithium ionic battery

The invention discloses lithium cobalt oxide composite cathode material and a process for preparation thereof, and a secondary lithium ion battery, which aims at solving the technical problem that the cathode material has excellent cycle performance and rate discharge property. The lithium cobalt oxide composite cathode material in the invention uses lithium cobalt oxide granules as basal bodies,and has grain size within 11-16 micron, wherein a lithium manganese oxide coating layer which accounts for 0.5-5% mass ratio of the basal body is coated on the outer side of the basal body. The process for preparation comprises preparing lithium manganese oxide precursors and coating lithium cobalt oxide. The anode of the secondary lithium ion battery is formed by an anode current collector and anode active substances which are coated on the anode current collector, wherein the anode active substance contains lithium cobalt oxide basal body, and the outer side of the basal body is coated withthe ...

Anti-PD-L1 antibodies and methods of making and using same

The present application provides anti-PD-L1 monoclonal antibodies, antigen-binding portions thereof, therapeutic compositions thereof, and/or nucleic acids encoding the same, and their use to upregulate T cell function to enhance cell-mediated immune responses in the treatment of cancer and other T cell dysfunctions.

MULTI-SPECIFIC ANTIBODIES AND METHODS OF MAKING AND USING THEREOF

Method for preparation of monodisperse phase-change microcapsule

The invention relates to a phase transition microcapsule, in particular to a preparation method of a monodisperse phase transition microcapsule with controllable size and surface shape and appearance and the microcapsule obtained by the preparation method thereof. The microcapsule is prepared by covering organic capsule cores that have a phase transition function through a heat-resistant polymer capsule wall. First, certain amount of capsule core materials are added into water to be emulsified and dispersed, water soluble polymer capsule wall prepolymer is added and the temperature is continued to be raised; pH value of the solution is adjusted to 3.5-5.5 by dripping acidizing fluid slowly; reacted and cured products are filtered, cleaned and dried repeatedly and finally the monodisperse phase transition microcapsule with controllable size and surface shape and appearance is obtained. The phase transition microcapsule produced by the invention has stable performance, controllable size and ...

Permanent magnetism magnetic body system for rotating magnetic refrigerating device

The present invention provides a permanent magnetism magnetic body system for a rotating magnetic refractor. The permanent magnetism magnetic body of a stator is made up of two permanent magnetism blocks with 180 degree phase difference in spatial position, charging magnetism direction of two permanent magnetism blocks is same, and is along the radial direction of stator. Guide magnet yoke of stator is hollow circular cylinder shaped, and is made up of magnetic conduction metallic material; two permanent magnetism blocks is fixed on the inner wall of guide magnet yoke; a circular arc shaped of permanent magnetism blocks is identical with the inner wall of guide magnet yoke, another crown face is concentric with inner wall of guide magnet yoke. Centre point of the rotor is superposition with geometric centre point of stator guide magnet yoke. Rotor guide magnet heart is a cylinder with centre hole or a cylinder scraping both sides, and is mounted on rotor shaft. Magnetic working substance ...

Non-contact driving device of rotary type conducting liquid permanent magnet

The invention provides a non-contact driving device of a rotary type conducting liquid permanent magnet, which comprises a cylinder body, a suction and discharge one-way valve, a connecting tube, a permanent magnet and a rotary motion driving device of the permanent magnet, wherein the cylinder body is a partially hollow circular body with an arced central line and made from non-magnetic-conducting materials; an outer wall of the cylinder body is a thin wall; the front end part of the cylinder body is connected with the connecting tube of a liquid pipe by a suction valve, and the back end part of the cylinder body is connected with the connecting tube of the liquid pipe by a discharge valve; the permanent magnet is made from permanent magnet materials, arranged outside the outer wall of the cylinder body, and has a certain gap with the outer wall of the cylinder body; the permanent magnet generates a dipolar or multipolar field in the circular cylinder body; the rotary center point ofthe ...

Crude vegetal paint

The invention relates to a natural plant paint formed by mixing natural plant resins, natural plant pigments, pigment aids, solvents and natural fillers, wherein the natural plant resin adopts 30-40 parts of rice bran oil, 20-30 parts of epoxy resins and 5-15 parts of alkyd resins by weight; the natural plant pigment adopts 10-20 parts of natural pigments by weight; the pigment aid adopts 3-5 parts of rare earth drier oil and 3-5 parts of dispersant by weight; the solvent adopts 8-20 parts of tobacco bar and 8-20 parts of rosin water by weight; and the natural filler adopts 4-6 parts of terrazzo powder by weight. The paint prepared by mixing the above components can not only reduce the volatile quantity of organic compounds but also reduce the content of heavy metals, thus effectively reducing pollution and being beneficial to environment protection. The product has rich film texture, is not easy to generate static electricity in case of friction, and has excellent water resistance, elasticity ...

Method for compatibilizing polyamide/polyester blend

The invention relates to a method for compatibilizing a polyamide/polyester blend by adopting a hyperbranched polymer. Taking PEI graft nylon with a hyperbranched structure as a compatibilizer, based on the total mass of 100 weight parts of blending components, namely polyamide and polyester, the compatibilizer is more than or equal to 1 weight part and is less than 15 weight parts, and the mixture ratio of the blending components, namely the polyamide to the polyester is 10: 90-90: 10. The method comprises the steps of: utilizing a solution blending method to obtain a blend, optionally performing heat treatment at a high temperature, and producing a terpolymer by an in-situ reaction so as to compatibilize the blend to obtain a polyamide/polyester alloy material with improved compatibility. The method is simple and high in efficiency, and can control the degree of the compatibilization to obtain blending materials which meet various needs and have different morphologies.

External magnetic field driving system of permanent magnet used for artificial heart

The invention relates to an external magnetic field driving system of a permanent magnet used for an artificial heart. In the invention, a driving magnet is positioned outside a human body; a first driven magnet and a second driven magnet are positioned inside the human body; the driving magnet is closed in an immovable casing and is driven by a motor to rotate; the first driven magnet is positioned between the driving magnet and the second driven magnet, and the rotation center line of the first driven magnet is parallel to the rotation center lines of the driving magnet and the second driven magnet; the first driven magnet is closed in an immovable casing, and the casing is fixed in the thorax of the human body; the second driven magnet is positioned in the ascending aorta of the heart,and the rotation center line of the second driven magnet is parallel to that of the first driven magnet; and the second driven magnet and an impeller of a blood pump are connected together.

Method for designing axial modification curve for reducing gear surface distortion

The invention belongs to the field of gear design and relates to a method for designing an axial modification curve for reducing gear surface distortion. The method for designing the axial modification curve for reducing gear surface distortion solves the problem of gear surface distortion during grinding of a bevel gear subjected to axial modification. Different from a traditional modification curve, the modification curve designed through the method can effectively weaken distortion at the two ends of the gear. The method comprises the steps that the distortion quantity of the left gear surface and the right surface of the gear is calculated according to the gear grinding technique and based on a standard parabola modification curve, then the curve is divided into three sections, and the scaling factor of each curve section and the drum-shaped size of each portion are adjusted.

Synchronizing shaft error compensation method of numerical control gear manufacturing machine tool

The invention discloses a synchronizing shaft error compensation method of a numerical control gear manufacturing machine tool. A virtual shaft which is additionally arranged in an electronic gearbox of the numerical control gear manufacturing machine tool is taken as a driving shaft, and coincides with a following shaft in synchronizing shafts; the error compensation amount of each shaft in the synchronizing shafts is converted into an equivalent compensation amount of the virtual shaft by the corresponding synchronization coefficients; the total equivalent compensation amount of the synchronizing shafts is obtained by linear superposition, and finally, the error compensation of the synchronizing shafts is realized by utilizing the theoretical motion of the virtual shaft. According to the method, after the error of each shaft is obtained, the compensation to a single shaft is not needed, the hardware and system parameters of the machine tool are not changed, and the precision needed by ...

Physical laboratory system based on universe

The invention discloses a physics laboratory system based on a meta universe. The physics laboratory system comprises a meta universe world part and a real world part, the element universal world part is arranged in the computer, and physical experiment parameters are input into the element universal world part through the real world part; the meta universal world part comprises an experiment script setting module, a user substitute and virtual user management module and a calculation simulation processing unit; the experiment script setting module is used for setting and selecting a corresponding experiment script to set the flow of the whole physical experiment; the user substitute and virtual user management module is used for setting a user substitute and a virtual user; the calculation simulation processing unit is used for calling and executing a corresponding experiment script through an experiment script setting module to complete a corresponding physical experiment process, and ...

Permanent-magnet synchronous generator having composite armature winding

A POLYLACTIC ACID STEREOCOMPLEX COMPOSITION, ITS MOLDED PRODUCT, A PROCESS FOR ITS MANUFACTURE AND ITS APPLICATION

INTERLEUKIN-2 MUTEINS FOR THE EXPANSION OF T-REGULATORY CELLS

Provided herein are IL-2 muteins, IL-2 mutein Fc-fusion molecules, anti-IL-2 antibodies, and complexes comprising an anti IL-2 antibody bound to an IL-2 cytokine that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgG1 Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also provided herein are linker peptides that are glycosylated when expressed in mammalian cells. Also provided herein are methods of making and using the compositions of the present invention.

Interior activated carbon paint

The invention relates to an interior activated carbon paint, comprising a compound material A and a compound material B, wherein A is a mixture of a natural plant resin, natural plant pigment, a pigment assistant, a solvent and natural stuffing; the natural plant resin comprises 30-40 parts of rice bran oil, 20-30 parts of epoxy resins and 5-15 parts of alkyd resins by weight; the natural plant pigment comprises 10-20 parts of natural pigment by weight; the pigment assistant comprises 3-5 parts of rare earth drier oil and 3-5 parts of dispersant by weight; the solvent comprises 8-20 parts of tobacco tar and 8-20 parts of rosin water by weight; and the natural stuffing comprises 4-6 parts of terrazzo powder; B is composed of 3-6 parts of activated carbon and 20-40 parts of tung oil by weight. The paint prepared by mixing the above components can not only reduce the volatile quantity of organic compounds but also reduce the content of heavy metals, thus effectively reducing pollution and ...

Multispecific antibodies and methods of making and using same

The present disclosure provides a tetraspecific antibody monomer having an N-terminal and a C-terminal comprising, in order from the N-terminal to the C-terminal, a first scFv domain at the N-terminal, a Fab domain, an Fc domain, a second scFv domain, and a third scFv at the C-terminal, wherein the first scFv domain, the Fab domain, the second scFv domain, and the third scFv domain each have binding specificity for different antigens. In one embodiment, the antigen is a tumor antigen, an immune signal antigen, or a combination thereof. Also provided are multispecific antibodies comprising the disclosed tetraspecific antibodies.

METHODS OF MAKING AND USING GUIDANCE AND NAVIGATION CONTROL PROTEINS

The application provides methods for generating a therapeutic composition. The method includes the steps of providing a cell material comprising a cytotoxic cell, incubating the cell material with a first GNC protein to provide an activated cell composition, wherein the activated cell composition comprises a first therapeutic cell, and formulating the activated cell composition to provide a therapeutic composition, wherein the therapeutic composition is substantially free of exogenous viral and non-viral DNA or RNA. The first GNC protein comprises a first cytotoxic binding moiety and a first cancer targeting moiety, wherein the first cytotoxic binding moiety has a specificity to a first cytotoxic cell receptor and is configured to activate the first cytotoxic cell, and wherein the first cancer targeting moiety has a specificity to a first cancer cell receptor. The first therapeutic cell comprises the first GNC protein bound to the cytotoxic cell through the first cytotoxic cell receptor. 1. A method for generating a therapeutic composition , comprisingproviding a cell material comprising a cytotoxic cell, wherein the first GNC protein comprising a first cytotoxic binding moiety and a first cancer targeting moiety, wherein the first cytotoxic binding moiety has a specificity to a first cytotoxic cell receptor and is configured to activate the first cytotoxic cell through the binding with the first cytotoxic cell receptor, and wherein the first cancer targeting moiety has a specificity to a first cancer cell receptor, and', 'wherein the first therapeutic cell comprises the first GNC protein bound to the cytotoxic cell through the binding interaction with the first cytotoxic cell receptor, and, 'incubating the cell material with a first GNC protein to provide an activated cell composition, wherein the activated cell composition comprises a first therapeutic cell,'}formulating the activated cell composition to provide a therapeutic composition, wherein the therapeutic ...

INTERLEUKIN-2 MUTEINS FOR THE EXPANSION OF T-REGULATORY CELLS

Provided herein are IL-2 muteins, IL-2 mutein Fc-fusion molecules, anti-IL-2 antibodies, and complexes comprising an anti IL-2 antibody bound to an IL-2 cytokine that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgG1 Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also provided herein are linker peptides that are glycosylated when expressed in mammalian cells. Also provided herein are methods of making and using the compositions of the present invention. 1. A human interleukin-2 (IL-2) mutein comprising an amino acid sequence that is at least 90% identical to the amino acid sequence set forth in SEQ ID NO:1 , wherein said IL-2 mutein has at least one mutation selected from L12G , L12K , L12Q , L12S , Q13G , E15A , E15G , E15S , H16A , H16D , H16G , H16K , H16M , H16N , H16R , H16S , H16T , H16V , H16Y , L9A , L19D , L19E , L19G , L9N , L19R , L19S , L19T , L19V , D20A , D20E , D20F , D20G , D20T , D20W , M23R , R81A , R81G , R81S , R81T , D84A , D84E , D84G , D84I , D84M , D84Q , D84R , D84S , D84T , S87R , N88A , N88D , N88E , N88F , N88G , N88M , N88R , N88S , N88V , N88W , V91D , V91E , V91G , V91S , I92K , I92R , and E95G and preferentially stimulates T regulatory cells relative to other T cells or NK cells , both in in vitro assays and in humanized mice (NSG mice reconstituted with CD34+ hematopoietic stem cells).2. (canceled)3. (canceled)4. The human IL-2 mutein of further comprising a mutation at C125A.5. (canceled)6. An Fc-fusion protein comprising an Fc and the human IL-2 mutein of .7. (canceled)8. The Fc-fusion protein of claim 7 , wherein the human IgG1 Fc comprises one or more mutations altering effector function of said Fc.9. The Fc-fusion protein of claim 8 , wherein the human IgG1 comprises a substitution at N297.10. The Fc-fusion protein of claim 9 , wherein the substitution at N297 is ...

ANTI-4-1BB ANTIBODIES AND METHODS OF MAKING AND USING THEREOF

The application provides anti-4-1BB monoclonal antibodies, antigen binding portions thereof, therapeutic compositions thereof and/or nucleic acid encoding the same, and their use to upregulate the function of T-cells to enhance cell-mediated immune responses in the treatment of cancer and other T-cell dysfunctional disorders. 1. An isolated monoclonal antibody (mAb) or antigen-binding fragment thereof that binds specifically to human or cynomolgus 4-1BB , comprising an amino acid sequence having at least 98% identity with SEQ ID NO:4 , SEQ ID NO:8 , SEQ ID NO:12 , SEQ ID NO:16 , SEQ ID NO:20 , SEQ ID NO:24 , SEQ ID NO:28 , SEQ ID NO:32 , SEQ ID NO:36 , SEQ ID NO:40 , SEQ ID NO:44 , SEQ ID NO:48 , SEQ ID NO:52 , SEQ ID NO:56 , SEQ ID NO:60 , SEQ ID NO:64 , SEQ ID NO:68 , SEQ ID NO:72 , SEQ ID NO:76 , SEQ ID NO:80 , SEQ ID NO:84 , SEQ ID NO:88 , SEQ ID NO:88 , SEQ ID NO:92 , SEQ ID NO:96 , SEQ ID NO:100 , SEQ ID NO:104 , SEQ ID NO:108 , SEQ ID NO:112 , SEQ ID NO:116 , SEQ ID NO:120 , SEQ ID NO:124 , SEQ ID NO:128 , SEQ ID NO:132 , SEQ ID NO:136 , SEQ ID NO:140 , SEQ ID NO:144 , SEQ ID NO:148 , SEQ ID NO:152 , SEQ ID NO:156 , SEQ ID NO:160 , SEQ ID NO:164 , SEQ ID NO:168 , SEQ ID NO:172 , SEQ ID NO:176 , SEQ ID NO:180 , SEQ ID NO:184 , SEQ ID NO:188 , SEQ ID NO:192 , SEQ ID NO:196 , SEQ ID NO:200 , SEQ ID NO:204 , SEQ ID NO:208 , SEQ ID NO:212 , SEQ ID NO:216 , SEQ ID NO:220 , SEQ ID NO:224 , SEQ ID NO:228 , SEQ ID NO:232 , SEQ ID NO:236 , SEQ ID NO:240 , SEQ ID NO:244 , SEQ ID NO:248 , SEQ ID NO:252 , SEQ ID NO:256 , SEQ ID NO:260 , SEQ ID NO:264 , SEQ ID NO:268 , or SEQ ID NO:272.2. (canceled)3. The isolated mAb or antigen-binding fragment according to claim 1 , having a binding affinity to human or cynomolgus 4-1BB with a Kd not greater than 70 nM.4. The isolated mAb or antigen-binding fragment according to claim 1 , exhibiting one or more functional properties selected from high affinity binding to human or cynomolgus 4-1BB claim 1 , inhibiting human or cynomolgus ...

MULTI-SPECIFIC ANTIBODIES AND METHODS OF MAKING AND USING THEREOF

The application provides tri-specific antibody monomers having a N-terminal and a C-terminal, comprising in tandem from the N-terminal to the C-terminal, a first scFv domain at the N-terminal, a Fab domain, a Fc domain, and a second scFv domain at the C-terminal. In one embodiment, the first scFv domain, the Fab domain, and the second scFv domain each has a binding specificity against a different antigen. 2. The tri-specific antibody monomer of claim 1 , wherein the first scFv domain claim 1 , the Fab domain claim 1 , and the second scFv domain each independently has a binding specificity against an antigen selected from ROR1 claim 1 , PD-L1 claim 1 , CD3 claim 1 , CD28 claim 1 , 41BB claim 1 , CEA claim 1 , HER2 claim 1 , EGFRvIII claim 1 , EGFR claim 1 , LMP1 claim 1 , LMP2A claim 1 , Mesothelin claim 1 , PSMA claim 1 , EpCAM claim 1 , glypican-3 claim 1 , gpA33 claim 1 , GD2 claim 1 , TROP2 claim 1 , NKG2D claim 1 , BCMA claim 1 , CD19 claim 1 , CD20 claim 1 , CD33 claim 1 , CD123 claim 1 , CD22 claim 1 , CD30 claim 1 , PDL1 claim 1 , PD1 claim 1 , OX40 claim 1 , 4-1BB claim 1 , GITR claim 1 , TIGIT claim 1 , TIM-3 claim 1 , LAG-3 claim 1 , CTLA4 claim 1 , CD40 claim 1 , VISTA claim 1 , ICOS claim 1 , BTLA claim 1 , LIGHT claim 1 , HVEM claim 1 , CSF1R claim 1 , CD73 claim 1 , and CD39.3. The tri-specific antibody monomer of claim 1 , wherein the first scFv domain claim 1 , the Fab domain claim 1 , and the second scFv domain each independently has a binding specificity against an antigen selected from ROR1 claim 1 , PD-L1 claim 1 , and CD3.4. The tri-specific antibody monomer of claim 1 , wherein the first scFv domain has a binding specificity against ROR1.5. The tri-specific antibody monomer of claim 1 , wherein the Fab domain has a binding specificity against PD-L1.6. The tri-specific antibody monomer of claim 1 , wherein the second scFv domain has a binding specificity against CD3.7. The tri-specific antibody monomer of claim 1 , wherein the first scFv domain ...

ANTI-CD3 ANTIBODIES AND METHODS OF MAKING AND USING THEREOF

The applications provides the anti-CD3 monoclonal antibodies, antigen-binding portions thereof, therapeutic compositions thereof and/or nucleic acid encoding the same, and their use to active CD3+ T-cells to enhance cell-mediated immune responses in the treatment of cancer and other T-cell dysfunctional disorders. 1. An isolated monoclonal antibody (mAb) or antigen-binding fragment thereof having a binding specificity to human CD3 , wherein the isolated mAb or antigen-binding fragment comprises an amino acid sequence having an identity with a sequence selected from SEQ ID NO:4 , SEQ ID NO:8 , SEQ ID NO:12 , SEQ ID NO:16 , SEQ ID NO:20 , SEQ ID NO:24 , SEQ ID NO:28 , SEQ ID NO:32 , SEQ ID NO:36 , SEQ ID NO:40 , SEQ ID NO:44 , SEQ ID NO:48 , SEQ ID NO:52 , SEQ ID NO:56 , SEQ ID NO:60 , SEQ ID NO:64 , SEQ ID NO:68 , or SEQ ID NO:72 , wherein the identity is not less than at least 98%.2. The isolated monoclonal antibody (mAb) or antigen-binding fragment according to claim 1 , wherein the identity is not less than 98%.3. The isolated mAb or antigen-binding fragment according to claim 1 , having a binding affinity to human CD3 with a Kd not greater than 70 nM.4. The isolated mAb or antigen-binding fragment according to claim 1 , wherein the isolated mAb or antigen-binding fragment is capable of high affinity binding to CD3 claim 1 , enhancing T cell activation claim 1 , stimulating antibody response claim 1 , or reversing the suppressive function of an immunosuppressive cell.5. The isolated mAb or antigen-binding fragment according to claim 4 , wherein the enhancing T-cell activation comprises T-cell proliferation claim 4 , IFN-γ and/or IL-2 secretion claim 4 , or a combination thereof.6. The isolated mAb or antigen-binding fragment according to claim 4 , wherein the immunosuppressive cell comprises a T regulatory cell.7. The isolated mAb or an antigen-binding fragment thereof according to claim 1 , wherein the isolated mAb is a humanized antibody claim 1 , a chimeric ...

ANTI-PD-1 ANTIBODIES AND METHODS OF MAKING AND USING THEREOF

The application provides anti-PD-1 monoclonal antibodies, antigen binding portions thereof, therapeutic compositions thereof and/or nucleic acid encoding the same, and their use to upregulate the function of T-cells to enhance cell-mediated immune responses in the treatment of cancer and other T-cell dysfunctional disorders. 1. An isolated mAb or antigen-binding fragment thereof having a binding specificity to human PD-1 , comprising an amino acid sequence having a percentage homology with SEQ ID NO:4 , SEQ ID NO:8 , SEQ ID NO:12 , SEQ ID NO:16 , SEQ ID NO:20 , SEQ ID NO:24 , SEQ ID NO:28 , SEQ ID NO:32 , SEQ ID NO:36 , SEQ ID NO:40 , SEQ ID NO:44 , SEQ ID NO:48 , SEQ ID NO:52 , SEQ ID NO:56 , SEQ ID NO:60 , SEQ ID NO:64 , SEQ ID NO:68 , SEQ ID NO:72 , or SEQ ID NO:80 , wherein the percentage homology is not less than 90%2. The isolated mAb or antigen-binding fragment according to claim 1 , wherein the percentage homology is not less than 98%.3. The isolated mAb or antigen-binding fragment according to claim 1 , having a binding affinity to human PD-1 with a Kd not greater than 70 nM.4. The isolated mAb or antigen-binding fragment according to claim 1 , exhibiting one or more functional properties selected from high affinity binding to human PD-1 claim 1 , inhibiting binding of human PD-L1 to PD-1 claim 1 , enhancing T cell activation claim 1 , stimulating antibody response claim 1 , reversing the suppressive function of an immunosuppressive cell claim 1 , or a combination thereof.6. The isolated mAb or antigen-binding fragment according to claim 4 , wherein the enhancing T-cell activation comprises T-cell proliferation claim 4 , IFN-γ and/or IL-2 secretion claim 4 , or a combination thereof.8. The isolated mAb or antigen-binding fragment thereof according to claim 1 , wherein the isolated mAb is a humanized antibody claim 1 , a chimeric antibody claim 1 , or a recombinant antibody.9. The isolated mAb or antigen-binding fragment thereof according to claim 1 , ...

MULTI-SPECIFIC ANTIBODIES AND METHODS OF MAKING AND USING THEREOF

The disclosure provides a tetra-specific antibody monomer having a N-terminal and a C-terminal, comprising in tandem from the N-terminal to the C-terminal, a first scFv domain at the N-terminal, a second scFv domain, a Fab domain, a Fc domain, and a third scFv at the C-terminal, wherein the first scFv domain, the second scFv domain, the Fab domain, and the third scFv domain each has a binding specificity against a different antigen. In one embodiment, the antigen is a tumor antigen, an immune signaling antigen, or a combination thereof. In one embodiment, the antigen includes CD19, CD3, CD137, 4-1BB, and PD-L1. Multi-specific antibodies comprising the disclosed tetra-specific antibodies are also provided. 1. A tetra-specific antibody monomer having a N-terminal and a C-terminal , comprising in tandem from the N-terminal to the C-terminal ,a first scFv domain at the N-terminal,a second scFv domaina Fab domain,a Fc domain, anda third scFv at the C-terminal,wherein the first scFv domain, the second scFv domain, the Fab domain, and the third scFv domain each has a binding specificity against a different antigen, and wherein the antigen is a tumor antigen, an immune signaling antigen, or a combination thereof.2. The tetra-specific antibody monomer of claim 1 , wherein the first scFv domain claim 1 , the second scFv domain claim 1 , the Fab domain claim 1 , and the third scFv domain each independently has a binding specificity against an antigen selected from ROR1 claim 1 , PD-L1 claim 1 , CD3 claim 1 , CD28 claim 1 , 41BB claim 1 , CEA claim 1 , HER2 claim 1 , EGFRvIII claim 1 , EGFR claim 1 , LMP1 claim 1 , LMP2A claim 1 , Mesothelin claim 1 , PSMA claim 1 , EpCAM claim 1 , glypimay-3 claim 1 , gpA33 claim 1 , GD2 claim 1 , TROP2 claim 1 , NKG2D claim 1 , BCMA claim 1 , CD19 claim 1 , CD20 claim 1 , CD33 claim 1 , CD123 claim 1 , CD22 claim 1 , CD30 claim 1 , PD1 claim 1 , OX40 claim 1 , 4-1BB claim 1 , GITR claim 1 , TIGIT claim 1 , TIM-3 claim 1 , LAG-3 claim 1 , ...

ULTRA WIDE BAND FIXED PHASE SHIFTER BASED ON CAPACITIVE LOAD

The present invention discloses an ultra wide band fixed phase shifter based on a capacitive load, which includes N physically separated phase shift units, and each phase shift unit includes an orthocoupler, first and second transmission lines, and first and second capacitive loads, wherein the orthocoupler includes an input end, a coupling end, a direct-connection end and an isolation end, one end of the first transmission line serves as a signal input end of the phase shift unit and the other end is connected with the input end of the orthocoupler, one end of the second transmission line serves as a signal output end of the phase shift unit and the other end is connected with the isolation end of the orthocoupler; one end of the first capacitive load is connected with the coupling end of the orthocoupler and the other end is grounded; one end of the second capacitive load is connected with the direct-connection end of the orthocoupler and the other end is grounded. The ultra wide band fixed phase shifter based on a capacitive load has compact structure, small area occupation and small insertion loss, does not need extra power supply and logical control, and can be widely applied. 1. An ultra wide band fixed phase shifter based on a capacitive load , comprising:N physically separated phase shift units, (N−1) phase shift states being implemented by accessing signal input ends and signal output ends of different phase shift units, wherein:each phase shift unit comprises an orthocoupler, first and second transmission lines, and first and second capacitive loads, wherein the orthocoupler comprises an input end, a coupling end, a direct-connection end and an isolation end, one end of the first transmission line serves as a signal input end of the phase shift unit and the other end is connected with the input end of the orthocoupler, one end of the second transmission line serves as a signal output end of the phase shift unit and the other end is connected with the ...

Anti-ror1 antibodies and methods of making and using thereof

The application provides anti-ROR1 monoclonal antibodies, antigen binding portions thereof, therapeutic compositions thereof and/or nucleic acid encoding the same, and their use to upregulate the function of T-cells to enhance cell-mediated immune responses in the treatment of cancer and other T-cell dysfunctional disorders.

A polylactic acid stereocomplex composition, its molded product, a process for its manufacture and its application

The instant invention discloses a polylactic acid stereocomplex composition containing pure stereocomplex crystals and a process for its manufacture. The composition according to this invention comprising (a) 30-70 wt % poly (L-lactic acid) (PLLA). (b) 70-30 wt % poly (D-lactic acid) (PDLA) and (c) 0.01-10 wt % nucleating agent, which can be obtained by solution and melt blending. Stereocomplex crystals are preferentially formed according to the invention, and the homocrystals (a crystal form) for the PLLA or PDLA homopolymer can't be observed. The melting temperature of the composition according to the invention is at least 200° C., which is about 30-50° C. higher than the PLLA or PDLA homopolymer.

BISPECIFIC ANTIBODIES AND METHODS OF MAKING AND USING THEREOF

The disclosure provides bispecific antibodies having the binding specificity to at least two of human CTLA4, PD-1 or PD-L1. In one embodiment, the bispecific antibody comprises IgG domains having heavy chains and light chains, and two scFv components being connected to either C-terminal of the heavy chains or N-terminal of the light chains, wherein the IgG domains have the binding specificity to a first antigen, wherein the scFv components have the binding specificity to a second antigen, and wherein the first antigen and the second antigen are different and are independently selected from a-CTLA4, α-PD-1, and α-PD-L1. 1. A bispecific antibody comprising IgG domains having heavy chains and light chains , and two scFv components being connected to either C terminal of the heavy chains or N terminal of the light chains , wherein the IgG domains have the binding specificity to a first antigen , wherein the scFv components have the binding specificity to a second antigen , and wherein the first antigen and the second antigen are different and are independently selected from α-CTLA4 , α-PD-1 , and α-PD-L1.2. The bispecific antibody of claim 1 , wherein the two scFv components are connected to the C terminal of the heavy chain.3. The bispecific antibody of claim 2 , wherein the first antigen comprises α-CTLA4 and the second antigen comprises α-PD-1 or α-PD-L1.4. The bispecific antibody of claim 2 , wherein the first antigen comprises α-PD-1 or α-PD-L1 and the second antigen comprises α-CTLA4.5. The bispecific antibody of claim 1 , wherein the two scFv components are connected to the N terminal of the light chain.6. The bispecific antibody of claim 5 , wherein the first antigen comprises α-PD-1 or α-PD-L1 and the second antigen comprises α-CTLA4.7. The bispecific antibody of claim 5 , wherein the first antigen comprises α-CTLA4 and the second antigen comprises α-PD-1 or α-PD-L1.8. (canceled)9. The bispecific antibody of claim 1 , comprising an antigen-binding fragment ...

A polylactic acid stereocomplex composition, its molded product, a process for its manufacture and its application

The instant invention discloses a polylactic acid stereocomplex composition containing pure stereocomplex crystals and a process for its manufacture. The composition according to this invention comprising (a) 30-70wt% poly (L-lactic acid) (PLLA). (b) 70-30wt% poly (D-lactic acid) (PDLA) and (c) 0.01 -10wt% nucleating agent, which can be obtained by solution and melt blending. Stereocomplex crystals are preferentially formed according to the invention, and the homocrystals (a crystal form) for the PLLA or PDLA homopolymer can't be observed. The melting temperature of the composition according to the invention is at least 200 °C, which is about 30-50 °C higher than the PLLA or PDLA homopolymer.

Interleukin-2 muteins for the expansion of t-regulatory cells.

Se proporcionan aquí muteínas de IL-2, moléculas de fusión de muteína de IL-2 Fc, anticuerpos anti-IL-2 y complejos que comprenden un anticuerpo anti-IL-2 unido a una citoquina de IL-2 que expanden y activan preferiblemente células T reguladoras y son susceptibles de producción a gran escala. También se proporcionan aquí moléculas Fc de IgG1 humanas variantes que carecen o con función efectora altamente reducida y alta estabilidad a pesar de que carecen de glicosilación en N297. También se proporcionan aquí péptidos enlazadores que están glicosilados cuando se expresan en células de mamífero. También se proporcionan en la presente invención métodos para fabricar y usar las composiciones de la presente invención.

Interleukin-2 muteins for the expansion of t-regulatory cells

Provided herein are IL-2 muteins, IL-2 mutein Fc-fusion molecules, anti-IL-2 antibodies, and complexes comprising an anti IL-2 antibody bound to an IL-2 cytokine that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgG1 Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also provided herein are linker peptides that are glycosylated when expressed in mammalian cells. Also provided herein are methods of making and using the compositions of the present invention.

Interleukin-2 muteins for the expansion of T-regulatory cells

Provided herein are IL-2 muteins, IL-2 mutein Fc-fusion molecules, anti-IL-2 antibodies, and complexes comprising an anti IL-2 antibody bound to an IL-2 cytokine that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgG1 Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also provided herein are linker peptides that are glycosylated when expressed in mammalian cells. Also provided herein are methods of making and using the compositions of the present invention.

Interleukin-2 muteins for the expansion of t-regulatory cells

Provided herein are IL-2 muteins, IL-2 mutein Fc-fusion molecules, anti-IL-2 antibodies, and complexes comprising an anti IL-2 antibody bound to an IL-2 cytokine that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgG1 Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also provided herein are linker peptides that are glycosylated when expressed in mammalian cells. Also provided herein are methods of making and using the compositions of the present invention.

Guidance and navigation control proteins and method of making and using thereof

The application provides guidance and navigation control (GNC) proteins. In one embodiment, the guidance and navigation control (GNC) protein, comprising a binding domain for a T cell activating receptor, a binding domain for a tumor associated antigen, a bind domain for an immune checkpoint receptor, and a binding domain for a T cell co-stimulating receptor. The binding domain for the tumor associated antigen is not adjacent to the binding domain for the T cell co-stimulating receptor. In one embodiment, the binding domain for the T cell activating receptor is adjacent to the binding domain for the tumor associated antigen (TAA).

STEREOCOMPLEX COMPOSITION OF POLYLACTIC ACID, ITS MOLDED PRODUCT, PROCESS FOR ITS MANUFACTURING AND APPLICATION

composição estereocomplexa de ácido poliláctico, seu produto moldado, processo para a sua fabricação e sua aplicação. a presente invenção divulga uma composição estereocomplexa de ácido poliláctico contendo cristais estereocomplexos puros e um processo para a sua fabricação. a composição de acordo com esta invenção que compreende (a) de 30 a 70 % em peso de poli (ácido l-láctico) (plla), (b) de 70 a 30 % em peso de poli (ácido d-láctico) (pdla) e (c) de 0,01 a 10 % em peso de agente de nucleação, o qual pode ser obtido através de solução e mistura em fusão. os cristais estereocomplexos são preferencialmente formados de acordo com a invenção, e os homocristais (uma forma de cristal) para o homopolímero de plla ou pdla não podem ser observados. a temperatura de fusão da composição de acordo com a invenção é de pelo menos 200 ºc, a qual é ao redor de 30 a 50 ºc mais elevada do que o homopolímero de plla ou pdla.

Polyolefin films with capability of being directly coated and method therefor

A directly coated polyolefin film and preparation method therefor, characterized in that the polyolefin film comprises a graft layer of a certain thickness, the polar element content in the graft layer is 20-35 wt%, and the film has good surface properties. The method for preparing the polyolefin film comprises the following steps: placing the surface of the polyolefin film in a plasma reaction chamber, introducing gaseous polar molecules and adjusting temperature and pressure, and performing a low temperature plasma treatment to complete a gas phase grafting reaction. The directly coated polyolefin film prepared by using the foregoing method has good printability and secure adhesion, and the surface polarity thereof can be effectively maintained.

Methods of making and using guidance and navigation control proteins

The application provides methods for generating a therapeutic composition. The method includes the steps of providing a cell material comprising a cytotoxic cell, incubating the cell material with a first GNC protein to provide an activated cell composition, wherein the activated cell composition comprises a first therapeutic cell, and formulating the activated cell composition to provide a therapeutic composition, wherein the therapeutic composition is substantially free of exogenous viral and non-viral DNA or RNA. The first GNC protein comprises a first cytotoxic binding moiety and a first cancer targeting moiety, wherein the first cytotoxic binding moiety has a specificity to a first cytotoxic cell receptor and is configured to activate the first cytotoxic cell, and wherein the first cancer targeting moiety has a specificity to a first cancer cell receptor. The first therapeutic cell comprises the first GNC protein bound to the cytotoxic cell through the first cytotoxic cell receptor.

Directly coated polyolefin film and preparation method therefor

Anti-CD3 antibodies and methods of making and using thereof

The applications provides the anti-CD3 monoclonal antibodies, antigen-binding portions thereof, therapeutic compositions thereof and/or nucleic acid encoding the same, and their use to active CD3+ T-cells to enhance cell-mediated immune responses in the treatment of cancer and other T-cell dysfunctional disorders.

Multi-specific antibodies and methods of making and using thereof

The disclosure provides a tetra-specific antibody monomer having a N-terminal and a C-terminal, comprising in tandem from the N-terminal to the C-terminal, a first scFv domain at the N-terminal, a second scFv domain, a Fab domain, a Fc domain, and a third scFv at the C-terminal, wherein the first scFv domain, the second scFv domain, the Fab domain, and the third scFv domain each has a binding specificity against a different antigen. In one embodiment, the antigen is a tumor antigen, an immune signaling antigen, or a combination thereof. In one embodiment, the antigen includes CD19, CD3, CD137, 4-1BB, and PD-L1. Multi-specific antibodies comprising the disclosed tetra-specific antibodies are also provided.

Premixing compressor for supplying air and gas mixture into combustion chamber of gas burner to heat water in e.g. commercial application, has electric motor whose output shaft is coupled to impeller that is fastened to output shaft

Ein Vormischgebläse zum Einspeisen eines Luft- und Gasgemisches in eine Verbrennungskammer eines Gasbrenners weist ein Gehäuse (20) mit einem Einlass (22) und einem Auslass (24) in Kommunikation mit dem Einlass und ein in dem Gehäuse (20) angeordnetes Gebläserad (40) auf, das an einer Ausgangswelle (62) eines Elektromotors (60) gekoppelt ist und zum Drehen des Gebläserads ausgelegt ist. Das Gebläserad (40) ist aus Metall gefertigt.

Interleukin 2 muteins for regulatory t cell expansion

<p>Se proporcionan aquí muteinas de IL-2, moléculas de fusión de muteína de I-2 Fc, anticuerpos anti-IL-2 y complejos que comprenden un anticuerpo anti-IL-2 unido a una citoquina de IL-2 que expanden y activan preferiblemente células T reguladoras y son susceptibles de producción a gran escala.También se proporcionan aquí moléculas Fc de IgG1 humanas variantes que carecen o con función efectora altamente reducida y alta estabilidad a pesar de que carecen de glicosilación en N297. También se proporcionan aquí péptidos enlazadores que están glicosilados cuando se expresan en células de mamífero. También se proporcionan en la presente invención métodos para fabricar y usar las composiciones de la presente invención.</p> <p> IL-2 muteins, I-2 Fc mutein fusion molecules, anti-IL-2 antibodies and complexes comprising an anti-IL-2 antibody bound to an IL-2 cytokine that expand are provided herein. and preferably activate regulatory T cells and are susceptible to large-scale production. Variant human IgG1 Fc molecules that lack or with highly reduced effector function and high stability are also provided here although they lack glycosylation in N297. Linker peptides that are glycosylated when expressed in mammalian cells are also provided herein. Methods for manufacturing and using the compositions of the present invention are also provided in the present invention. </p>

Interleukin-2 muteins for the expansion of t-regulatory cells

Provided herein are IL-2 muteins, IL-2 mutein Fc-fusion molecules, anti-IL-2 antibodies, and complexes comprising an anti IL-2 antibody bound to an IL-2 cytokine that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgG1 Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also provided herein are linker peptides that are glycosylated when expressed in mammalian cells. Also provided herein are methods of making and using the compositions of the present invention.

Bispecific antibodies and methods of making and using thereof

The disclosure provides bispecific antibodies having the binding specificity to at least two of human CTLA4, PD-1 or PD-L1. In one embodiment, the bispecific antibody comprises IgG domains having heavy chains and light chains, and two scFv components being connected to either C-terminal of the heavy chains or N-terminal of the light chains, wherein the IgG domains have the binding specificity to a first antigen, wherein the scFv components have the binding specificity to a second antigen, and wherein the first antigen and the second antigen are different and are independently selected from a-CTLA4, α-PD-1, and α-PD-L1.

Selective sound source listening in conjunction with computer interactive processing

Multi-specific antibodies and methods of making and using thereof

The disclosure provides a tetra-specific antibody monomer having a N-terminal and a C-terminal, comprising in tandem from the N-terminal to the C-terminal, a first scFv domain at the N-terminal, a Fab domain, a Fc domain, a second scFv domain, and a third scFv at the C-terminal, wherein the first scFv domain, the Fab domain, the second scFv domain, and the third scFv domain each has a binding specificity against a different antigen. In one embodiment, the antigen is a tumor antigen, an immune signaling antigen, or a combination thereof. Multi-specific antibodies comprising the disclosed tetra-specific antibodies are also provided.

Anti-pd-1 antibodies and methods of making and using thereof

Electronic trading confirmation system

Published without an Abstract

A message sending method, system and device thereof

本發明實施例公開了一種訊息傳輸方法、裝置和系統，其中，方法包括：付款終端獲取銷售終端顯示的包括支付訊息的圖形編碼，並對圖形編碼進行解碼以獲取支付訊息；付款終端根據支付訊息向銀行伺服器發送包括付款帳號和付款帳號的驗證訊息的支付請求；銀行伺服器處理支付請求，並將處理支付請求的處理結果發送給付款終端和銷售終端。

Guidance and navigation control proteins and method of making and using thereof

The application provides guidance and navigation control (GNC) proteins. In one embodiment, the GNC protein Comprises a T-cell binding moiety and a cancer-targeting moiety, wherein the T-cell binding moiety has a binding specificity to a T-cell receptor comprising CD3, CD28, PDL1, PD1, OX40, 4-1BB, GITR, TIGIT, TIM-3, LAG-3, CTLA4, CD40, VISTA, ICOS, BTLA, Light, NKp30, CD28H, CD27, CD226, CD96, CD112R, A2AR, CD160, CD244, CECAM1, CD200R, TNFRSF25 (DR3), or a combination thereof, and wherein the cancer targeting moiety has a binding specificity to a cancer cell receptor.

Centrifugal impeller

A centrifugal impeller includes a body of antistatic plastic and a back plate made of metal, preferably aluminium. The back plate is fixed to the body is such a way that the back plate can not make accidental contact with a volute of a blower in which the impeller is deployed.

Composición de estereocomplejo de poli(ácido láctico), su producto moldeado, procedimiento para su fabricación y su aplicación

La presente invención describe una composición estereocompleja de ácido poliláctico que contiene cristales estereocomplejos puros y un proceso para su fabricación. La composición según esta invención comprende (a) 30-70% en peso de poli(ácido L-láctico) (PLLA). (b) 70-30% en peso de poli(ácido D-láctico) (PDLA) y (c) 0,01-10% en peso de agente de nucleación, que se puede obtener mediante mezcla en solución y en estado fundido. Según la invención se forman preferentemente cristales estereocomplejos y no se pueden observar los homocristales (una forma cristalina) para el homopolímero PLLA o PDLA. La temperatura de fusión de la composición según la invención es al menos 200 °C, que es aproximadamente 30-50 °C más alta que la del homopolímero PLLA o PDLA. (Traducción automática con Google Translate, sin valor legal)

Novel phenylpropanoid compound

Provided is a novel active ingredient derived from locust bean and the use thereof. The present invention is a compound represented by the following formula (I) or a salt thereof, or a solvate thereof.

Novel isoflavone compound

Provided is a novel active ingredient derived from locust bean and the use thereof. The present invention is a compound represented by the following formula (I) or a salt thereof, or a solvate thereof.

Multi-specific antibodies and methods of making and using thereof

The application provides tri-specific antibody monomers having a N-terminal and a C-terminal, comprising in tandem from the N-terminal to the C-terminal, a first scFv domain at the N-terminal, a Fab domain, a Fc domain, and a second scFv domain at the C-terminal. In one embodiment, the first scFv domain, the Fab domain, and the second scFv domain each has a binding specificity against a different antigen.

Anti-4-1bb antibodies and methods of making and using thereof

The application provides anti-4-1BB monoclonal antibodies, antigen binding portions thereof, therapeutic compositions thereof and/or nucleic acid encoding the same, and their use to upregulate the function of T-cells to enhance cell-mediated immune responses in the treatment of cancer and other T-cell dysfunctional disorders.

Novel polyphenol compound

Provided is a novel active ingredient derived from locust bean and the use thereof. The present invention is a compound represented by the following formula (I) or a salt thereof, or a solvate thereof.

Interleukin-2 muteins for the expansion of T-regulatory cells

Provided herein are IL-2 muteins, IL-2 mutein Fc-fusion molecules, anti-IL-2 antibodies, and complexes comprising an anti IL-2 antibody bound to an IL-2 cytokine that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgGI Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also provided herein are linker peptides that are glycosylated when expressed in mammalian cells. Also provided herein are methods of making and using the compositions of the present invention.

Anti-4-1bb antibodies and methods of making and using thereof

The application provides anti-4-1BB monoclonal antibodies, antigen binding portions thereof, therapeutic compositions thereof and/or nucleic acid encoding the same, and their use to upregulate the function of T-cells to enhance cell-mediated immune responses in the treatment of cancer and other T-cell dysfunctional disorders.

抗ｐｄ－ｌ１抗体とその作製及び使用方法

【課題】がん及びＴ細胞機能障害の治療においてＴ細胞の機能をアップレギュレートし、細胞性免疫応答を増強するために用いられる、抗ＰＤーＬ1モノクローナル抗体を提供する。【解決手段】ヒトＰＤ－Ｌ１に対する結合特異性を有する単離されたｍＡｂ又はその抗原結合断片であって、前記ｍＡｂ又はその抗原結合断片は、特定のアミノ酸配列を含む軽鎖可変領域及び特定のアミノ酸配列を含む重鎖可変領域を含む、単離されたｍＡｂ又はその抗原結合断片を提供する。【選択図】なし

A polylactic acid stereocomplex composition, its molded product, a process for its manufacture and its application

Multi-specific antibodies and methods of making and using thereof

The disclosure provides a tetra-specific antibody monomer having a N-terminal and a C-terminal, comprising in tandem from the N-terminal to the C-terminal, a first scFv domain at the N-terminal, a Fab domain, a Fc domain, a second scFv domain, and a third scFv at the C-terminal, wherein the first scFv domain, the Fab domain, the second scFv domain, and the third scFv domain each has a binding specificity against a different antigen. In one embodiment, the antigen is a tumor antigen, an immune signaling antigen, or a combination thereof. Multi-specific antibodies comprising the disclosed tetra-specific antibodies are also provided.

Method and device for extracting additives from plastic-based material

The present invention concerns a method for extracting an additive from a material containing a polymer matrix and said additive comprising the steps of a) bringing into contact said material with a pressurized dense fluid in a device at a temperature T and a pressure p at which said pressurized dense fluid is saturated with said additive and b) creating in said device either a temperature gradient or a pressure gradient whereby said device presents a gradient of solubility of said additive with a zone of minimum solubility in which said additive precipitates or crystallizes and a zone of maximum solubility containing said material depleted in said additive, step a) and step b) being performed simultaneously or one after the other one. The present invention also concerns a multi- vessel device implemented during this extraction method.

Guidance and navigation control proteins and method of making and using thereof

The application provides guidance and navigation control (GNC) proteins. In one embodiment, the guidance and navigation control (GNC) protein, comprising a binding domain for a T cell activating receptor, a binding domain for a tumor associated antigen, a bind domain for an immune checkpoint receptor, and a binding domain for a T cell co-stimulating receptor. The binding domain for the tumor associated antigen is not adjacent to the binding domain for the T cell co-stimulating receptor. In one embodiment, the binding domain for the T cell activating receptor is adjacent to the binding domain for the tumor associated antigen (TAA).

Decomposed multi-stream (DMS) techniques for video display systems

Anti-4-1BB antibodies and methods of making and using thereof

The application provides anti-4-1BB monoclonal antibodies, antigen binding portions thereof, therapeutic compositions thereof and/or nucleic acid encoding the same, and their use to upregulate the function of T-cells to enhance cell-mediated immune responses in the treatment of cancer and other T-cell dysfunctional disorders.

Multi-specific antibodies and methods of making and using thereof

The application provides tri-specific antibody monomers having a N-terminal and a C-terminal, comprising in tandem from the N-terminal to the C-terminal, a first scFv domain at the N-terminal, a Fab domain, a Fc domain, and a second scFv domain at the C-terminal. In one embodiment, the first scFv domain, the Fab domain, and the second scFv domain each has a binding specificity against a different antigen.

Interleukin-2 muteins for the expansion of T-regulatory cells

Provided herein are IL-2 muteins, IL-2 mutein Fc-fusion molecules, anti-IL-2 antibodies, and complexes comprising an anti IL-2 antibody bound to an IL-2 cytokine that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgG1 Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also provided herein are linker peptides that are glycosylated when expressed in mammalian cells. Also provided herein are methods of making and using the compositions of the present invention.

切断装置

【課題】作業中、埃っぽい状態になってしまうことのない室内用の切断装置を提供する。【解決手段】室内用の切断装置は、固定シェル３に取り付けられた、コネクター１０を備えた駆動装置２と減速機５を有する。切断装置の収容腔のスペースが大きいため、第1扇形防塵シェルの伸縮部分が第2扇形防塵シェルの第1円形穴を塞ぐことがなく、切断装置に接続されたダスト吸引装置は、ほこりを吸引し続けることができ、ガイド板には第２傾斜面が設けられているため、切断装置は、切断プロセス中に、飛散した小さな石とほこりを、ガイド板によって、第２扇形防塵シェルの収容腔に入れることができる。第２扇形防塵シェルの収容腔の第１円形穴に近い部分が大きくなるため、収容腔は石とほこりをより多く収容でき、効果的にほこりを吸引する。【選択図】図１

Muteína de il-2; proteína de fusión; ácido nucleico; vector; célula hospedera; métodos; uso

Se describe una muteína de interleucina-2 humana (IL-2) que comprende una secuencia de aminoácidos de SEC ID No. 1, en donde dicha muteína de IL-2 tiene al menos una mutación seleccionada de L12G, L12K, L12Q y L12S; una proteína de fusión que comprende un fragmento cristalizable de inmunoglobulina (Fc) y la muteína de IL-2 humana; un ácido nucleico aislado que codifica la muteína de IL-2 humana; un ácido nucleico aislado que codifica una porción Fc de un anticuerpo y las muteínas de IL-2 humanas; un vector de expresión que comprende el ácido nucleico aislado unido operativamente a un promotor; una célula hospedera que comprende el ácido nucleico aislado; un método para preparar una muteína de IL-2 humana que comprende cultivar la célula hospedera; un método para preparar una proteína de fusión Fc que comprende cultivar la célula hospedera; un método in vitro para aumentar la relación de células T reguladoras (Tregs) a células T no reguladoras dentro de una población de células T que comprende poner en contacto la población de células T con una cantidad eficaz de una muteína de IL-2 humana; un método in vitro para aumentar la relación de células T reguladoras (Treg) a células T no reguladoras dentro de una población de células T que comprende poner en contacto la población de células T con una cantidad eficaz de una proteína de fusión Fc; uso de la muteína de IL-2 para preparar un medicamento útil para tratar una enfermedad inflamatoria o autoinmune; uso de la proteína de fusión Fc para preparar un medicamento útil para tratar una enfermedad inflamatoria o autoinmune.

Muteína de il-2; proteína de fusión; ácido nucleico; vector; célula hospedera; métodos; uso

Se describe una muteína de interleucina-2 humana (IL-2) que comprende una secuencia de aminoácidos de SEC ID No. 1, en donde dicha muteína de IL-2 tiene al menos una mutación seleccionada de L12G, L12K, L12Q y L12S; una proteína de fusión que comprende un fragmento cristalizable de inmunoglobulina (Fc) y la muteína de IL-2 humana; un ácido nucleico aislado que codifica la muteína de IL-2 humana; un ácido nucleico aislado que codifica una porción Fc de un anticuerpo y las muteínas de IL-2 humanas; un vector de expresión que comprende el ácido nucleico aislado unido operativamente a un promotor; una célula hospedera que comprende el ácido nucleico aislado; un método para preparar una muteína de IL-2 humana que comprende cultivar la célula hospedera; un método para preparar una proteína de fusión Fc que comprende cultivar la célula hospedera; un método in vitro para aumentar la relación de células T reguladoras (Tregs) a células T no reguladoras dentro de una población de células T que comprende poner en contacto la población de células T con una cantidad eficaz de una muteína de IL-2 humana; un método in vitro para aumentar la relación de células T reguladoras (Treg) a células T no reguladoras dentro de una población de células T que comprende poner en contacto la población de células T con una cantidad eficaz de una proteína de fusión Fc; uso de la muteína de IL-2 para preparar un medicamento útil para tratar una enfermedad inflamatoria o autoinmune; uso de la proteína de fusión Fc para preparar un medicamento útil para tratar una enfermedad inflamatoria o autoinmune.

Novel polyphenol compound

Provided is a novel active ingredient derived from locust bean and the use thereof. The present invention is a compound represented by the following formula (I) or a salt thereof, or a solvate thereof.

Guidance and Navigation Control proteins and method of making and using thereof

The application provides guidance and navigation control (GNC) proteins. In one embodiment, the guidance and navigation control (GNC) protein, comprising a binding domain for a T cell activating receptor, a binding domain for a tumor associated antigen, a bind domain for an immune checkpoint receptor, and a binding domain for a T cell co-stimulating receptor. The binding domain for the tumor associated antigen is not adjacent to the binding domain for the T cell co-stimulating receptor. In one embodiment, the binding domain for the T cell activating receptor is adjacent to the binding domain for the tumor associated antigen (TAA).

Muteinas de interleuquina 2 para la expansion de celulas t regulatorias.

Se proporcionan aquí muteínas de IL-2, moléculas de fusión de muteína de IL-2 Fc, anticuerpos anti-IL-2 y complejos que comprenden un anticuerpo anti-IL-2 unido a una citoquina de IL-2 que expanden y activan preferiblemente células T reguladoras y son susceptibles de producción a gran escala. También se proporcionan aquí moléculas Fc de IgG1 humanas variantes que carecen o con función efectora altamente reducida y alta estabilidad a pesar de que carecen de glicosilación en N297. También se proporcionan aquí péptidos enlazadores que están glicosilados cuando se expresan en células de mamífero. También se proporcionan en la presente invención métodos para fabricar y usar las composiciones de la presente invención.

Muteína de il-2; proteína de fusión; ácido nucleico; vector; célula hospedera; métodos; uso

Se describe una muteína de interleucina-2 humana (IL-2) que comprende una secuencia de aminoácidos de SEC ID No. 1, en donde dicha muteína de IL-2 tiene al menos una mutación seleccionada de L12G, L12K, L12Q y L12S; una proteína de fusión que comprende un fragmento cristalizable de inmunoglobulina (Fc) y la muteína de IL-2 humana; un ácido nucleico aislado que codifica la muteína de IL-2 humana; un ácido nucleico aislado que codifica una porción Fc de un anticuerpo y las muteínas de IL-2 humanas; un vector de expresión que comprende el ácido nucleico aislado unido operativamente a un promotor; una célula hospedera que comprende el ácido nucleico aislado; un método para preparar una muteína de IL-2 humana que comprende cultivar la célula hospedera; un método para preparar una proteína de fusión Fc que comprende cultivar la célula hospedera; un método in vitro para aumentar la relación de células T reguladoras (Tregs) a células T no reguladoras dentro de una población de células T que comprende poner en contacto la población de células T con una cantidad eficaz de una muteína de IL-2 humana; un método in vitro para aumentar la relación de células T reguladoras (Treg) a células T no reguladoras dentro de una población de células T que comprende poner en contacto la población de células T con una cantidad eficaz de una proteína de fusión Fc; uso de la muteína de IL-2 para preparar un medicamento útil para tratar una enfermedad inflamatoria o autoinmune; uso de la proteína de fusión Fc para preparar un medicamento útil para tratar una enfermedad inflamatoria o autoinmune.

Programming method for multi-layered flash memory array and switching control method thereof

新規イソフラボン化合物

【課題】イナゴマメ由来の新規な活性成分及びその用途を提供する。【解決手段】イナゴマメ莢果の含水アルコール抽出物を石油エーテル、酢酸エチルの順に液液抽出を行い、酢酸エチル画分から分離される新規イソフラボン配糖体、若しくはその塩又はそれらの溶媒和物を提供する。該化合物はアクアポリン３産生促進作用及びフィラグリン２産生促進作用を備え、皮膚バリア機能改善効果を有すると共に抗炎症作用を有する。【選択図】なし

新規フェニルプロパノイド化合物

【課題】イナゴマメ由来の新規な活性成分及びその用途を提供すること。【解決手段】本発明は、下記式（Ｉ）で表される化合物若しくはその塩又はそれらの溶媒和物である。TIFF2022185604000011.tif76168【選択図】なし

Novel isoflavone compound

Provided is a novel active ingredient derived from locust bean and the use thereof. The present invention is a compound represented by the following formula (I) or a salt thereof, or a solvate thereof.

Methods of making and using guidance and navigation control proteins

The application provides methods for generating a therapeutic composition. The method includes the steps of providing a cell material comprising a cytotoxic cell, incubating the cell material with a first GNC protein to provide an activated cell composition, wherein the activated cell composition comprises a first therapeutic cell, and formulating the activated cell composition to provide a therapeutic composition, wherein the therapeutic composition is substantially free of exogenous viral and non-viral DNA or RNA. The first GNC protein comprises a first cytotoxic binding moiety and a first cancer targeting moiety, wherein the first cytotoxic binding moiety has a specificity to a first cytotoxic cell receptor and is configured to activate the first cytotoxic cell, and wherein the first cancer targeting moiety has a specificity to a first cancer cell receptor. The first therapeutic cell comprises the first GNC protein bound to the cytotoxic cell through the first cytotoxic cell receptor.

制御性ｔ細胞の増殖のためのインターロイキン－２変異タンパク質

【課題】ヒト治療薬に最適な属性を有するＩＬ－２変異タンパク質を提供する。【解決手段】ある特定のアミノ酸配列と少なくとも９０％同一のアミノ酸配列を含むヒトインターロイキン－２（ＩＬ－２）変異タンパク質であって、インビトロアッセイ及びヒト化マウス（ＣＤ３４＋造血幹細胞で再構成されたＮＳＧマウス）の両方において、その他のＴ細胞またはＮＫ細胞と比較して制御性Ｔ細胞を優先的に刺激する、ヒトＩＬ－２変異タンパク質である。【選択図】なし

A process for the recycling of neodymium from waste printed circuit boards

The present invention relates to the field of recovery of rare-earth metals, in particular to a process for the recovery of neodymium (Nd) from e-wastes from ceramic -based electronic components, in particular from waste printed circuit boards (PCBs).

Novel phenylpropanoid compound

Provided is a novel active ingredient derived from locust bean and the use thereof. The present invention is a compound represented by the following formula (I) or a salt thereof, or a solvate thereof.

Guidance and navigation control proteins and method of making and using thereof

The application provides guidance and navigation control (GNC) proteins. In one embodiment, the guidance and navigation control (GNC) protein, comprising a binding domain for a T cell activating receptor, a binding domain for a tumor associated antigen, a bind domain for an immune checkpoint receptor, and a binding domain for a T cell co-stimulating receptor. The binding domain for the tumor associated antigen is not adjacent to the binding domain for the T cell co-stimulating receptor. In one embodiment, the binding domain for the T cell activating receptor is adjacent to the binding domain for the tumor associated antigen (TAA).

Guidance and navigation control proteins and method of making and using thereof

The application provides guidance and navigation control (GNC) proteins. In one embodiment, the guidance and navigation control (GNC) protein, comprising a binding domain for a T cell activating receptor, a binding domain for a tumor associated antigen, a bind domain for an immune checkpoint receptor, and a binding domain for a T cell co-stimulating receptor. The binding domain for the tumor associated antigen is not adjacent to the binding domain for the T cell co-stimulating receptor. In one embodiment, the binding domain for the T cell activating receptor is adjacent to the binding domain for the tumor associated antigen (TAA).

Multi-specific antibodies and methods of making and using thereof

The disclosure provides a tetra-specific antibody monomer having a N-terminal and a C-terminal, comprising in tandem from the N-terminal to the C-terminal, a first scFv domain at the N-terminal, a Fab domain, a Fc domain, a second scFv domain, and a third scFv at the C-terminal, wherein the first scFv domain, the Fab domain, the second scFv domain, and the third scFv domain each has a binding specificity against a different antigen. In one embodiment, the antigen is a tumor antigen, an immune signaling antigen, or a combination thereof. Multi-specific antibodies comprising the disclosed tetra-specific antibodies are also provided.

Method and device for extracting additives from plastic-based material

The present invention concerns a method for extracting an additive from a material containing a polymer matrix and said additive comprising the steps of a) bringing into contact said material with a pressurized dense fluid in a device at a temperature T and a pressure p at which said pressurized dense fluid is saturated with said additive and b) creating in said device either a temperature gradient or a pressure gradient whereby said device presents a gradient of solubility of said additive with a zone of minimum solubility in which said additive precipitates or crystallizes and a zone of maximum solubility containing said material depleted in said additive, step a) and step b) being performed simultaneously or one after the other one. The present invention also concerns a multi- vessel device implemented during this extraction method.

Interleukin-2 muteins for the expansion of t-regulatory cells

Provided herein are IL-2 muteins, IL-2 mutein Fc-fusion molecules, anti-IL-2 antibodies, and complexes comprising an anti IL-2 antibody bound to an IL-2 cytokine that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgG1 Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also provided herein are linker peptides that are glycosylated when expressed in mammalian cells. Also provided herein are methods of making and using the compositions of the present invention.

Slope protection and water-soil pollution prevention and control structure conducive to the growth of plant roots and operation method therefor

A waterfront bank slope protection and water-soil pollution prevention and control structure having a floating sieve plate 2 hingedly attached to a slope surface 1 comprising, a flexible planting material 6 on the surface on the sieve plate, a rigid filter layer 3 including a box body filled with activated carbon fixing particles, a flexible filter layer 4 including activated carbon filter cotton structure, the bottom of the flexible layer attached to the top of the rigid layer, a filter plate provided between the top of the rigid layer and the bottom of the flexible layer, the top of the flexible layer attached to the bottom of a floating pressure plate 5, a flexible filter screen 7 provide between the floating sieve plate and the floating pressure plate, and telescope spring devices (8, Fig 2) provided between the bottom of the floating pressure plate and the top of the rigid flexible layer. A concrete blanket (10) may be on the slope, and additional water purifying algae tanks 9 may be adjacent filter blocks 3,4,5. The system reduces soil erosion and absorbs pollutant particles to improve plant health at waterside banks.

Multi-specific antibodies and methods of making and using thereof

The disclosure provides a tetra-specific antibody monomer having a N-terminal and a C-terminal, comprising in tandem from the N-terminal to the C-terminal, a first scFv domain at the N-terminal, a second scFv domain, a Fab domain, a Fc domain, and a third scFv at the C-terminal, wherein the first scFv domain, the second scFv domain, the Fab domain, and the third scFv domain each has a binding specificity against a different antigen. In one embodiment, the antigen is a tumor antigen, an immune signaling antigen, or a combination thereof. In one embodiment, the antigen includes CD19, CD3, CD137, 4-1BB, and PD-L1. Multi-specific antibodies comprising the disclosed tetra-specific antibodies are also provided.

水処理装置

【課題】細胞壁を破壊することなくアオコを除去することができるだけでなく、アオコの増殖を効率的に阻害することができ、アオコ毒素やアオコ異臭味物質の生成を防ぐことができる水処理装置を提供する。【解決手段】水処理装置は、陰極１１１が配置されている陰極室１１０と陽極１２１が配置されている陽極室１２０とを有する電解室１０と、陰極室１１０及び陽極室１２０へ原水を導入する原水導入部２０と、アルカリ性電解水を排出するためのアルカリ性電解水排出部３０と、酸性電解水を排出するための酸性電解水排出部４０と、陰極室１１０で生成されるガスを排出するための陰極排気口５０と、陽極室１２０で生成されるガスを排出するための陽極排気口６０を備え、陰極１１１及び陽極１２１がいずれも中空柱状に形成されている。【選択図】図１

Polylactic acid stereocomplex composition, its molded product, a process for its manufacture and its application

The instant invention discloses a polylactic acid stereocomplex composition containing pure stereocomplex crystals and a process for its manufacture. The composition according to this invention comprising (a) 30-70 wt % poly (L-lactic acid) (PLLA). (b) 70-30 wt % poly (D-lactic acid) (PDLA) and (c) 0.01-10 wt % nucleating agent, which can be obtained by solution and melt blending. Stereocomplex crystals are preferentially formed according to the invention, and the homocrystals (a crystal form) for the PLLA or PDLA homopolymer can't be observed. The melting temperature of the composition according to the invention is at least 200° C., which is about 30-50° C. higher than the PLLA or PDLA homopolymer.