06-06-2013 дата публикации
Номер: US20130144036A1
The present invention discloses compounds of formula I and II or pharmaceutically acceptable salts, esters, or prodrugs thereof: 1. A compound of Formula I or II:wherein{'sub': 2', '1, 'A is absent or selected from —(C═O)—, —S(O), —C═N—ORor —C(═N—CN);'}{'sub': 201', '1', '8', '2', '8', '2', '8', '1', '8', '2', '8', '2', '8', '3', '12', '3', '12', '3', '12', '3', '12, 'Lis absent or selected from —C-Calkylene, —C-Calkenylene, or —C-Calkynylene each containing 0, 1, 2, or 3 heteroatoms selected from O, S, or N; substituted —C-Calkylene, substituted —C-Calkenylene, or substituted —C-Calkynylene each containing 0, 1, 2, or 3 heteroatoms selected from O, S or N; —C-Ccycloalkylene, or substituted —C-Ccycloalkylene each containing 0, 1, 2, or 3 heteroatoms selected from O, S or N; —C-Ccycloalkenylene, or substituted —C-Ccycloalkenylene each containing 0, 1, 2, or 3 heteroatoms selected from O, S or N;'}{'sub': 2', '1', '1, 'M is absent or selected from O, S, SO, SOor NR; wherein Ris selected at each occurrence from the group consisting of(i) hydrogen;(ii) aryl; substituted aryl; heteroaryl; substituted heteroaryl;(iii) heterocycloalkyl or substituted heterocycloalkyl;{'sub': 1', '8', '2', '8', '2', '8', '3', '8', '2', '8', '2', '8', '3', '12', '3', '12', '3', '12', '3', '12, '(iv) —C-Calkyl, —C-Calkenyl, or —C-Calkynyl each containing 0, 1, 2, or 3 heteroatoms selected from O, S, or N; substituted —C-Calkyl, substituted —C-Calkenyl, or substituted —C-Calkynyl each containing 0, 1, 2, or 3 heteroatoms selected from O, S or N; —C-Ccycloalkyl, or substituted —C-Ccycloalkyl; —C-Ccycloalkenyl, or substituted —C-Ccycloalkenyl;'}{'sub': 101', '1', '8', '2', '8', '2', '8', '1', '8', '2', '8', '2', '8', '3', '12', '3', '12', '3', '12', '3', '12, 'Lis absent or selected from —C-Calkylene, —C-Calkenylene, or —C-Calkynylene each containing 0, 1, 2, or 3 heteroatoms selected from O, S, or N; substituted —C-Calkylene, substituted —C-Calkenylene, or substituted —C-Calkynylene each ...
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