26-10-2017 дата публикации
Номер: US20170305852A1
Принадлежит:
The present invention is directed to a compound represented by Structural Formula (I): 2. The compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein:{'sup': '2', 'X is selected from N and C(R);'}{'sup': 1', '2', '3', '5', '6', 'A', 'B', 'B′', 'B', 'B′', 'C, 'sub': 1', '6', '0-2', '0', '6', '0', '6, 'each of R, R, R, Rand Ris independently selected from hydrogen, halo, —(C-Calkyl), —OR, —C(O)NRR, NRR, S(O)R, —(C-Calkylene)-carbocyclyl, and —(C-Calkylene)-heterocyclyl; or'}{'sup': 1', '2, 'Rand Rare optionally taken together with atoms to which they are bound to form a carbocyclyl or heterocyclyl ring; or'}{'sup': 2', '3, 'Rand Rare optionally taken together with atoms to which they are bound to form a carbocyclyl or heterocyclyl ring;'}{'sup': '4', 'sub': 1', '6', '0', '6', '0', '6, 'Ris selected from hydrogen, —(C-Calkyl), —(C-Calkylene)-carbocyclyl, and —(C-Calkylene)-heterocyclyl;'}{'sup': 4′', 'C', 'D', 'E, 'sub': 2', '6', '1-2', '0', '6', '0', '6', '1', '6', '1', '6, 'R is selected from hydrogen, —(C-Calkyl), S(O)R, —(C-Calkylene)-carbocyclyl, —(C-Calkylene)-heterocyclyl, —C(O)—(C-Calkyl), and —C(O)—(C-Calkyl)-NRR; or'}{'sup': 4', '4′, 'Rand R are optionally taken together with the nitrogen atom to which they are commonly bound to form a 4-8 membered ring optionally comprising 1-2 additional heteroatoms independently selected from N, O and S;'}{'sup': '6′', 'sub': 1', '6', '3', '6, 'R is selected from hydrogen, —(C-Calkyl) and —(C-Ccycloalkyl);'}{'sup': A', 'D', 'E, 'sub': 1', '6', '0', '6', '0', '6', '1', '6', '0', '6', '0', '6, 'each Ris independently selected from hydrogen, —(C-Calkyl), —(C-Calkylene)-carbocyclyl, —(C-Calkylene)-heterocyclyl, —C(O)—(C-Calkyl), —C(O)—(C-Calkylene)-carbocyclyl, —C(O)—(C-Calkylene)-heterocyclyl, and —C(O)N(R)(R);'}{'sup': B', 'B′', 'D', 'E, 'sub': 1', '6', '0', '6', '0', '6', '1-2', '1', '6', '1-2', '0', '6', '1-2', '0', '6', '1', '6', '0', '6', '0', '6, 'each Rand each R is independently selected ...
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