ИНТЕГРАЛЬНАЯ СХЕМА С МАТРИЦЕЙ СЕНСОРНЫХ ТРАНЗИСТОРОВ, СЕНСОРНОЕ УСТРОЙСТВО И СПОСОБ ИЗМЕРЕНИЯ

Изобретение относится к аналитической химии. Раскрыта сенсорная матрица интегральной схемы (100), содержащей полупроводниковую подложку (110); изолирующий слой (120) поверх упомянутой подложки; первый транзистор (140a) на упомянутом изолирующем слое, содержащий открытую функционализированную область (146a) канала между областью (142a) истока и областью стока (144) для восприятия аналита в среде; второй транзистор (140b) на упомянутом изолирующем слое, содержащий открытую область (146b) канала между областью (142b) истока и областью (144) стока для восприятия потенциала упомянутой среды; и генератор (150) напряжения смещения, проводящим образом связанный с полупроводниковой подложкой для подачи на упомянутые транзисторы напряжения смещения, при этом упомянутый генератор напряжения смещения является реагирущим на упомянутый второй транзистор. Также раскрыты сенсорное устройство, содержащее такую ИС, и способ измерения аналита с использованием такой ИС. Изобретение обеспечивает формирование ...

СПОСОБ ВЫРАВНИВАНИЯ ПАРАМЕТРОВ КАНАЛОВ РЕГИСТРАЦИИ МНОГОКАНАЛЬНОГО НАНОПРОВОДНОГО ДЕТЕКТОРА

Изобретение относится к электронной технике, а более конкретно к области «Измерение электрических и магнитных величин». Устройство состоит из многоканального нанобиосенсора, каждый канал которого состоит из нанопроводного полевого транзистора, преобразователя ток-напряжение, сумматора 1, умножителя, суматора 2, АЦП, ЦАП, микропроцессора и ПЭВМ. Технологический разброс параметров нанопроводного полевого транзистора компенсируется за счет изменения коэффициента усиления усилителей и компенсации постоянной составляющей сигнала. Техническим результатом является снижение требования производства к повторяемости нанопроволочного детектора, что повышает процент годных к использованию нанопроволочных детекторов. 1 ил.

Состав для внедрения квантовых точек в полимерные матрицы чувствительных элементов люминесцентного сенсора для анализа биологических водных и водно-спиртовых сред и способ его изготовления

Изобретение может быть использовано при изготовлении чувствительных элементов оптических датчиков, предназначенных для анализа биологических водных и водно-спиртовых сред. Состав для внедрения в полимерные гидрофильные пористые матрицы содержит квантовые точки в микроэмульсии. Квантовые точки включают ядро на основе селенида кадмия и полупроводниковые оболочки на основе сульфида кадмия и/или сульфида цинка. Микроэмульсия включает водную фазу, содержащую воду или смесь воды с алифатическим спиртом в соотношении 1:1, неполярную фазу, содержащую неполярный растворитель, и фазу оксиэтилированного неионогенного поверхностно-активного вещества, обеспечивающего гидрофилизацию поверхности квантовых точек и выбранного из оксиэтилированного касторового масла (HRE-40), оксиэтилированного полисорбата (ТВИН-80) или оксиэтилированного октадециламина. В качестве указанной матрицы использован поливиниловый спирт или поливинилацетат. Технический результат: сохранение квантового выхода люминесценции полученных ...

Nanopore sensors comprising thin insulating materials

Plasmonic sensor with nanostructured surface

Analysing apparatus and method

An analysing apparatus 30 comprises a plasmonic sensor 10 and a sample chamber 34. The sensor comprises a transparent body having reverse 13 and obverse 14 faces; the reverse face is exposed to the chamber and comprises a plurality of nanostructures (16, Fig. 1A). The apparatus further comprises an excitation source 36 for directing a beam of electromagnetic radiation onto the reverse face of the body at an angle of incidence that causes no reflection from said face, and a detector 40 for receiving a beam of radiation emerging from the reverse face after its reflection from the nanostructured surface. The apparatus is suitable for analysing chemical or biological material. In one embodiment the nanostructures are elongate, and the longitudinal axis is disposed perpendicularly to the obverse face. The nanostructures may be substantially parallel and spaced apart. The transparent body may be planar, and the angle of incidence may be the Brewster angle.

Method for detecting an analyte based on the detection of a change of the mechanical properties of a freestanding nanoparticle composite material

A chemical sensor comprises a permeable freestanding nanoparticle composite material 3. A signal caused by a change of elastic modulus or pre-stress of material 3 is measured. The material may be suspended as a cantilever, beam or membrane over microcavity 6. Nanoparticles may be metal, metal oxide, semiconductor, carbon, metal dichalcogenide, core-shell, or Janus-type. A matrix of the composite may comprise organic polymers, polysiloxanes, organic ligands, or organic cross-linkers. A structural change or deformation of material 3 may be measured optically. Resistance, impedance, capacitance, spectral absorbance, reflectance or emission may be measured. Response to a static actuating force, or change in frequency, amplitude or phase in response to a dynamic force may be measured. Analyte concentration may be determined, after calibration. Analytes may be recognised from signal shapes. An array of sensors may be provided, and the sensor may be combined with sensors of other type.

Method of detecting and identifying a microorganism

Surface-Enhanced Raman Scattering (SERS) is used to identify microbes. This may be accomplished using a SERS-active surface. The surface comprises an electrode, covered with a sensing film. The electrode may be an (electrochemical) working electrode. The sensing film comprises noble metal nanoparticles, e.g. silver. These nanoparticles are wrapped in a polyelectrolyte to enhance the affinity for the target microorganism, e.g. bacteria, virus, parasite. The polyelectrolyte may be e.g. polyDADMAC, PAH or PSS. A first and second voltage are applied stepwise to the SERS-active surface. A SERS spectrum is generated. This spectrum is used as a fingerprint to identify the microbe. Spectrum data may be compared to a library of reference spectrum data of known microbes. The first voltage may be anodic and the second voltage cathodic. A positive voltage may be used. The nanoparticles may be functionalised with capture agents, e.g. antibodies. The electrode may be screen-printed.

Diagnostic probe

Diagnostic probe

Diagnostic probe

Method of identifying a structure

A method of analysis of a sample is described. The method includes providing a sample holder having an upper surface and a lower surface, the upper surface having a plasmonic layer associated therewith, the plasmonic layer including a periodic array of sub-micron structures. A sample is applied to the sample holder and illuminated. At least one localised structural property of the sample is visible in an image formed based on the colour of the received light. The method includes using the image formed to control a subsequent analysis process. The subsequent analysis process can be another microscopy process such as TEM, SEM or the like.

Substrate with buffer layer for oriented nanowire growth

The present invention provides a substrate (1) with a bulk layer (3) and a buffer layer (4) having a thickness of less than 2 m arranged on the bulk layer (3) for growth of a multitude of nanowires (2) oriented in the same direction on a surface (5) of the buffer layer (4). A nanowire structure, a nanowire light emitting diode comprising the substrate (1) and a production method for fabricating the nanowire structure is also provided. The production method utilizes non-epitaxial methods for forming the buffer layer (4).

Method to increase the number of detectable photons during the imaging of a biological marker

The present invention relates a method to determine the presence of a photon producing biological marker in a cell, tissue or organism of interest. The method is based on Fluorescence by Unbound Excitation from Luminescence (FUEL) and comprises the steps of a) providing conditions suitable for the biological marker to produce at least one first photon by luminescence; b) providing a FUEL probe pair-upper (FPP-U) disposed in proximity to the cell, tissue or organism, wherein the at least one first photon of step a) excites the FPP-U, which emits at least one second photon. The FPP-U may be selected from the group of quantum dots, carbon nanotubes, fluorescent proteins, diamond nanocrystals and metalloporphyrins. This method is charcterized in that said biological marker and said FPP-U are not bound and in that each of the at least one second photon (s) are of a longer wavelength than each of the at least one first photon (s).

Flow batteries having an electrode with a density gradient and methods for production and use thereof

Electrochemical cells, such as those present within flow batteries, can have at least one electrode with a density gradient in which the density increases outwardly from a separator. Such electrodes can decrease contact resistance and lessen the incidence of parasitic reactions in the electrochemical cell. Flow batteries containing the electrochemical cells can include: a first half-cell containing a first electrode, a second half-cell containing a second electrode, and a separator disposed between the first half-cell and the second half-cell. At least one of the first electrode and the second electrode has a density gradient such that a density of at least one of the first electrode and the second electrode increases outwardly from the separator.

NANOSENSORS

... ²²²Electrical devices comprised of nanowires are described, along with methods of ²their manufacture and use. The nanowires can be nanotubes and nanowires. The ²surface of the nanowires may be selectively functionalized. Nanodetector ²devices are described.² ...

METHOD AND SYSTEM OF FABRICATING PZT NANOPARTICLE INK BASED PIEZOELECTRIC SENSOR

The disclosure provides in one embodiment a method of fabricating a lead zirconate titanate (PZT) nanoparticle ink based piezoelectric sensor (110). The method has a step of formulating a lead zirconate titanate (PZT) nanoparticle ink (104). The method further has a step of depositing the PZT nanoparticle ink (104) onto a substrate (101) via an ink deposition process (122) to form a PZT nanoparticle ink based piezoelectric sensor (110).

ACTIVE COMPOSITE MATERIALS FOR MICRO-FLUIDIC AND NANO- FLUIDIC DEVICES

Microfluidic devices in applications such as biological and chemical sensing provide high sensitivity and exploit minute amounts of samples and reagents in solutions that are low cost, compact, portable and easily distributed to end-users, etc. Polydimethylsiloxane (PDMS) is a common material for the mechanical structure of the body, micro-channels etc. However, its inert nature and biocompatibility mean that active functionality must be added after the formation of the microfluidic structures and structural elements. It would be beneficial to provide designers of microfluidic devices with the ability to implement active elements for the detection of one or more components within a fluid or arising within a fluid from a reaction upstream using a composite comprising a mechanical component, such as the PDMS, with the active material for the active element of the microfluidic device embedded with the PDMS as a composite.

GIANT MAGNETORESISTANCE-BASED BIOSENSORS

Disclosed is a system for detecting one or more target analytes which includes a resistor structure comprised of a substrate, a graphene-based nanocomposite material located on a surface of the substrate with the graphene-based nanocomposite material exhibiting one or more magnetoresistance properties. A surface of the nanocomposite material includes molecular sensing elements bound thereto which exhibit an affinity for binding with the target analytes. Electrodes are connected to the resistor structure connectable to a power source and a device for measuring a resistance across the resistor structure for sensing a giant magnetoresistance (GMR) value of the resistor structure. Included are magnetic colloidal nanoparticles exhibiting preselected magnetic properties with an outer surface of the magnetic colloidal nanoparticles being modified to allow interaction with the surface of the resistor structure resulting in a change in the GMR value of the resistor structure. The resistor structure ...

NANOCONTACT MOLDING AND CASTING: FROM 3D FINGERPRINT PHANTOMS TO DESIGNED NANOSTRUCTURES

A method for fabricating a mold. The mold may comprise mold features with nanometer-scale resolution or minimum dimensions (e.g. the mold replicates nanometer-scale features of a master). The mold may comprise mold features with nanometer to micrometer-scale resolution or minimum dimensions (e.g. the mold replicates nanometer to micrometer-scale features of a master). The method may comprise providing a plate; applying a solvent to a first surface of the plate; allowing the solvent to penetrate from the first surface into the plate to thereby soften a first region of the plate, the first region of the plate including the first surface; pressing a master against the first region of the plate after the first region of the plate has softened to thereby deform at least a portion of the first region into a negative mold; and removing the master from contact with the plate.

BIOSENSING SYSTEMS HAVING BIOSENSORS COATED WITH CO-POLYMERS AND THEIR USES THEREOF

The present invention relates to biosensing systems having biosensors coated with co-polymers and their uses thereof.

METHODS AND SYSTEMS FOR PASSENGER MONITORING

Methods and systems for passenger monitoring and system control is provided. The system includes at least one sensor system configured to monitor an environment immediately surrounding the respective passenger and biometrics of the respective passenger and generate sensor data indicative of a state of the passenger. The system also includes a processing system configured to receive the sensor data. The processing system includes an ontology and reasoning module configured to model at least one of the plurality of passengers, reason about the received sensor data associated with the at least one of the plurality of passengers. The processing system also includes a contextual analyzer configured to transmit the received sensor data to said ontology and reasoning module and to store the information into a contextual information database.

SYSTEM AND METHOD OF DETECTING PATHOGENS

A method and system are provided for the simultaneous detection and identification of multiple pathogens in a patient sample. The sample is combined with microbeads, which have been injected with quantum dots or fluorescent dye and conjugated to pathogen-specific biorecognition molecules, such as antibodies and oligonucleotides. Treatment options may be determined based on the identities of the pathogens detected in the sample.

GENERATING A CONTROL SEQUENCE FOR QUANTUM CONTROL

In some aspects, a control system interacts with a quantum system. In some instances, the quantum system includes qubits that respond to a control signal generated by the control system, and the control system is configured to generate the control signal in response to an input signal. A control sequence (which may include, for example, a sequence of values for the input signal) can be generated by a computing system based on a target operation to be applied to the qubits. The control sequence can be generated based on the target operation, a quantum system model, a distortion model and possibly other information. The quantum system model represents the quantum system and includes a control parameter representing the control signal. The distortion model represents a nonlinear relationship between the control signal and the input signal. The control sequence is applied to the quantum system by operation of the control system.

ENVIRONMENTAL AND PRODUCT SENSING

Environmental and product sensing can include an electronic indicator, an electronic status indicator, and/or a sensing system, among others that include an environmentally sensitive component. The environmentally sensitive component can facilitate detection of a change in an environmental condition. The environmentally sensitive component can be a part of a circuit.

ANALYSIS OF A POLYMER COMPRISING POLYMER UNITS

A sequence of polymer units in a polymer (3), eg. DNA, is estimated from at least one series of measurements related to the polymer, eg. ion current as a function of translocation through a nanopore (1), wherein the value of each measurement is dependent on a k-mer being a group of k polymer units (4). A probabilistic model, especially a hidden Markov model (HMM), is provided, comprising, for a set of possible k-mers: transition weightings representing the chances of transitions from origin k-mers to destination k-mers; and emission weightings in respect of each k-mer that represent the chances of observing given values of measurements for that k-mer. The series of measurements is analysed using an analytical technique, eg. Viterbi decoding, that refers to the model and estimates at least one estimated sequence of polymer units in the polymer based on the likelihood predicted by the model of the series of measurements being produced by sequences of polymer units. In a further embodiment ...

NANOPARTICLE COMPOSITION AND ASSOCIATED METHODS THEREOF

A nanoparticle composition is provided, wherein the composition comprises a nanoparticulate metal oxide; and a phosphorylated polyol comprising at least two phosphate groups. The polyol comprises one or more hydrophilic groups selected from the group consisting of polyethylene ether moieties, polypropylene ether moieties, polybutylene ether moieties, and combinations of two or more of the foregoing hydrophilic moieties. A method of making the nanoparticle composition is also provided. The nanoparticle compositions provided by the present invention may be used as contrast agents in medical imaging techniques such as X-ray and magnetic resonance imaging.

BOOTSTRAPPING AND SYNTHESIS OF MECHANOSYNTHESIS TIPS

Processes are described for manufacturing atomically-precise tips using one or more tips in one or more mechanosynthetic reactions to create one or more atomically-precise tips. The processes may employ a variety of feedstock, binding any of a wide range of atoms to a workpiece to build the one or more atomically-precise tips. The processes result in atomically-precise mechanosynthesis tips with a wide variety of possible tip structures using a wide range of feedstock binding elements. Characteristics of such tips that may be used when designing new embodiments are also described.

Nanoparticles core-shell metal-silica, method of manufacturing and testing device immunochromatography comprising such nanoparticles.

La présente invention concerne une nanoparticule cur-coquille comprenant au moins un cur composé dau moins un premier matériau métallique à base dau moins un métal présentant une résonance plasmonique dans le domaine choisi parmi le domaine de lultraviolet, le domaine du visible et le domaine du proche infrarouge, et une coquille de silice, ladite silice comprenant des groupes fonctionnels. Selon linvention, la silice comprend à sa surface, liés de façon covalente, des agents de stabilisation de ladite nanoparticule. La présente invention concerne également une nanoparticule cur-coquille comprenant un cur composé dau moins ledit premier matériau et une coquille métallique réalisée dans un second matériau à base dau moins un métal présentant une résonance plasmonique dans le domaine choisi parmi le domaine de lultraviolet, le domaine du visible et le domaine du proche infrarouge, ledit second matériau étant différent du premier matériau, la coquille métallique étant stabilisée par un agent ...

Core-shell metal-silica, manufacturing method and test device by immunochromatography comprising such nanoparticles.

La présente invention concerne une nanoparticule cur-coquille comprenant au moins un cur composé dau moins un premier matériau métallique à base dau moins un métal présentant une résonance plasmonique dans le domaine choisi parmi le domaine de lultraviolet, le domaine du visible et le domaine du proche infrarouge, et une coquille de silice, ladite silice comprenant des groupes fonctionnels. Selon linvention, la silice comprend à sa surface, liés de façon covalente, des agents de stabilisation de ladite nanoparticule. La présente invention concerne également une nanoparticule cur-coquille comprenant un cur composé dau moins ledit premier matériau et une coquille métallique réalisée dans un second matériau à base dau moins un métal présentant une résonance plasmonique dans le domaine choisi parmi le domaine de lultraviolet, le domaine du visible et le domaine du proche infrarouge, ledit second matériau étant différent du premier matériau, la coquille métallique étant stabilisée par un agent ...

SENSOR SENSITIVE ELEMENT

ЧУВСТВИТЕЛЬНЫЙ ЭЛЕМЕНТ ДАТЧИКА

Изобретение относится к области технологии изготовления кремниевых микро- и наноэлектронных устройств. Изобретение может быть использовано для производства датчиков определения величины показателя рН различных биологических растворов, а также как составляющий элемент датчиков химических и биологических веществ, изготовленных по технологии производства кремниевых интегральных микросхем. Чувствительный элемент датчика содержит истоковые электроды р-типа 1 и n-типа 2 и общий стоковый электрод 3, имеющий области р-типа 4 и n-типа 5. Электроды выполнены на диэлектрическом слое 6 подложки 7. Истоковый электрод р-типа 1 соединен областью р-типа 4 стокового электрода 3 нанопроволокой 8, образуя ионочувствительный полевой транзистор р-типа. Истоковый электрод n-типа 2 соединен областью n-типа 5 стокового электрода 3 нанопроволокой 9, образуя ионочувствительный полевой транзистор n-типа. Таким образом, чувствительный элемент датчика содержит два ионочувствительных полевых транзистора р-типа и n-типа ...

СПОСОБ ИЗГОТОВЛЕНИЯ ГАЗОВОГО МУЛЬТИСЕНСОРА КОНДУКТОМЕТРИЧЕСКОГО ТИПА НА ОСНОВЕ ОКСИДА ОЛОВА

Изобретение относится к области газового анализа и может быть использовано для осуществления детектирования и анализа газов и многокомпонентных газовых смесей. Способ осуществляют методом электрохимического осаждения в емкости, оборудованной электродом сравнения и противоэлектродом и заполненной раствором, содержащим нитрат-анионы и катионы олова из солей SnCl2 с концентрацией 0,05-0,15 моль/л и NaNO3 с концентрацией 0,1-0,3 моль/л. Слой оксида олова в виде нанокристаллов осаждают с помощью циклической вольтамперометрии на диэлектрическую подложку, оборудованную полосковыми сенсорными электродами, выполняющими роль рабочего электрода, в растворе, величина pH которого составляет 1,45±0,02, путем изменения потенциала, подаваемого на сенсорные электроды, от 0 В в отрицательную сторону относительно потенциала электрода сравнения до величин не менее -1,7 В со скоростью развертки потенциала в диапазоне 0,02-0,25 В/с. Затем осуществляют увеличение потенциала до величины не выше +2,0 В и обратное ...

CONVERTER HEAT ENERGY ENVIRONMENT INTO ELECTRIC ENERGY

ФЕРМЕНТНЫЙ ПОТЕНЦИОМЕТРИЧЕСКИЙ БИОСЕНСОР ДЛЯ ОПРЕДЕЛЕНИЯ L-АРГИНИНА В ВОДНЫХ РАСТВОРАХ НА ОСНОВЕ pH-ЧУВСТВИТЕЛЬНЫХ ПОЛЕВЫХ ТРАНЗИСТОРОВ И ЭФФЕКТА ИНГИБИРОВАНИЯ УРЕАЗЫ

Изобретение относится к области здравоохранения, животноводства и пищевой промышленности и может быть применено, в частности, для определения концентрации L-аргинина в растворах с целью изучения функционального состояния ферментативной системы человека и животных, определения качества пищевых продуктов, а также в качестве конструктивного элемента аналитической системы, предназначенной для биохимического анализа сыворотки крови и вытяжек из мяса и мясопродуктов с целью диагностики нарушений белкового обмена и вызванных ими патологических изменений в работе органов и систем организма. Ферментный потенциометрический биосенсор (ФПБ) содержит потенциометрический датчик на основе двух pH-чувствительных полевых транзисторов, на один из которых нанесена рабочая ферментная мембрана на основе уреазы, чувствительной к L-аргинину, на второй нанесена мембрана сравнения на основе сывороточного альбумина белка. Указанный биосенсор интегрирован к измерительной ячейке, в которую установлен и электрод сравнения ...

ПРЕОБРАЗОВАТЕЛЬ ТЕПЛОВОЙ ЭНЕРГИИ ОКРУЖАЮЩЕЙ СРЕДЫ В ЭЛЕКТРИЧЕСКУЮ ЭНЕРГИЮ

Заявляемое изобретение относится к преобразователям тепловой энергии окружающей среды в электрическую энергию и предназначено для использования в качестве автономного источника электрической энергии. Заявляемый преобразователь тепловой энергии окружающей среды в электрическую энергию содержит по меньшей мере одну базовую многослойную твердотельную разноразмерную структуру, включающую слой B, контактирующий с одной стороны со слоем A1 через слой C, а с другой стороны со слоем A2 через слой D. Слой A1, выполненный из проводящего материала, толщина которого больше величины длины волны де Бройля, а уровень Ферми расположен в зоне проводимости. Слой B выполнен из проводящего материала в виде донорно легированного полупроводника или полуметалла, толщина которого должна быть меньше величины длины волны де Бройля, а уровень Ферми расположен в зоне проводимости. Слой C представляет собой нанопленку из проводящего материала или диэлектрика, толщина которого и состав материала позволяют организовать ...

A Pr doped In

A kind of targeting EGFR perfluorocarbon nano probe

Self-driven sensing system based on friction nano-generator

Superconducting nanowire and superconducting nanowire single photon detector

Polarization insensitive superconducting avalanche single photon detector

Lymph targeted prussian blue analog nano-particle and preparation method thereof

Touch sensor and preparation method thereof

Detecting an analyte

Magnetic nanoparticle for imaging guidance and preparation method thereof

INDIUM OXIDE NANOWIRE HAVING COPPER-BASED DOPANTS, METHOD OF FORMING THE SAME AND GAS SENSOR HAVING THE SAME, AND METHOD OF FORMING A PLURALITY OF NANOWIRES HAVING METAL PHTHALOCYANINE, NANOWIRE ARRANGEMENT AND GAS SENSOR HAVING THE PLURALITY OF METAL PHTHALOCYANINE NANOWIRES

Magnetic nanoparticle for rapid screening of estradiol

To increase biological marker can be detected during Image formation method of photon number

Pirani vacuum gauge of carbon nanotube and vacuum degree detection method thereof

Preparation method of multistage micro-nano motor

Monodispersion-induced movement of the laser in response to the one-dimensional organic semiconductor micron belt and its preparation method and application

Gold-substrate quasi-two-dimensional nano-scale sawteeth prepared by selective chemical etching of sulfydryl ligand and method thereof

The invention relates to a method for preparing quasi-two-dimensional nanoscale sawteeth by using a gold nano triangular plate or hexagonal plate as a substrate. According to the method, the tip position with the high curvature is preferentially protected on the surface of the gold nanosheet through the curvature specific affinity of a sulfydryl ligand (2-thionaphthol), the tip position becomes more and more sharp through chemical etching, the smooth position becomes deeper through etching, and finally continuous and uniform nanoscale sawteeth are formed. The nano material can be used as a novel functional complex nano material, and the unique nanoscale sawtooth structure of the nano material has the potential of becoming a future micro-nano tool. The method is simple to operate and high in universality, overturns the conventional etching rule which makes the nano structure become smoother and smoother, and provides a new method for synthesis of novel nano materials.

Gold nano bipyramid composite material as well as preparation method and application thereof

The invention discloses a gold nano bipyramid composite material and a preparation method and application thereof, the composite material is of a core-shell structure, a shell layer comprises a zeolite imidazate framework material (ZIF), and a core layer comprises gold nano bipyramid (Au-NBP). The gold nano bipyramid composite material with the core-shell structure is successfully prepared, the influence of the composite material on the charge transfer effect (CT) process and the synergistic SERS performance is researched by changing the thickness of the ZIF of the shell layer and different types of ZIF, and the research finds that the effect of the composite material is better than that of pure Au-NBPs in a Raman test.

GAS-DETECTOR PHOTOACOUSTIQUE HAS CELL OF HELMHOLTZ

L'invention concerne un dispositif de détection photoacoustique comprenant un circuit nanophotonique incluant une première puce sur laquelle sont formés au moins un guide d'onde optique (111) et dans laquelle est formé un ensemble de cavités (117, 119, 121, 123) définissant un résonateur de Helmholtz ; au moins une source optique (107) apte à émettre un signal optique dans une gamme de longueur d'onde donnée et modulable à une fréquence de modulation acoustique, cette source étant solidaire de la première puce ; une deuxième puce formant capot pour lesdites cavités et comprenant des détecteurs acoustiques ; et des circuits électroniques de traitement de la sortie des détecteurs acoustiques formés dans la première ou la deuxième puce.

MATERIAL ORGANIC HEART MAGNETIC-INORGANIC COATING, PREPARATION METHOD AND USES THEREOF FOR DELIVERING A MAGNETO-STIMULATED AND RELATIVE METHOD

La présente invention est relative à un matériau sub-micrométrique constitué d'une enveloppe de silice renfermant un cœur de cire superparamagnétique, à son procédé de préparation et à ses utilisations, notamment pour la délivrance magnéto-stimulée de substances d'intérêt.

MEASUREMENT SYSTEM INCLUDING A RESONATOR ARRAY SUCH AS NANO-ELECTROMECHANICAL SYSTEM

DEVICE FOR DETECTING BIOLOGICAL OR CHEMICAL ELECTRICAL READ

L'invention concerne un dispositif à lecture électrique pour la détection d'une espèce biochimique comportant un bio-capteur, lequel bio-capteur comprend : a. un substrat isolant ; b. une couche d'un nanocoupleur chimique greffée à la surface dudit substrat ; c. une assemblée de nanoparticules fonctionnalisée, structurée et cohésive avec la couche de nanocoupleur chimique, laquelle assemblée est apte à détecter l'espèce biochimique ; d. deux électrodes connectées électriquement avec ladite assemblée de nanoparticules.

MANUFACTORING PROCESS Of a BIOSENSOR

L'invention concerne un procédé de fabrication d'un biocapteur. Le biocapteur de l'invention comprend une micropoutre, qui est la partie mobile du biocapteur, reliée à un support, au moins une électrode dont une partie au moins est encastrée sur la micropoutre, au moins une molécule biologique A greffée sur la micropoutre dans une zone différente de la zone d'encastrement de la(des) électrode(s), un transducteur mécano-électrique de conversion en signal électrique des variations des propriétés mécaniques de la micropoutre, lorsque la molécule biologique A est mise en contact avec une molécule biologique B à détecter et/ou quantifier. Le procédé de l'invention est caractérisé en ce que la micropoutre et son support sont en un matériau fluoropolymère et forment une pièce intégrale, et en ce qu'il comprend les étapes suivantes : a) formation sur feuille en un matériau fluoropolymère d'au moins une électrode, b) optionnellement formation d'un plot en un matériau ferromagnétique sur la(les) ...

INK LUMINESCENT MARKING

La présente invention concerne une encre de marquage comprenant : - des particules d'au moins un luminophore ; - au moins un absorbeur ; - un solvant. L'encre est dépourvue de matériau de fritte et l'absorbeur est constitué de nanoparticules métalliques.

OLFACTORY RECEPTOR-FUNCTIONALIZED TRANSISTORS FOR HIGHLY SELECTIVE BIOELECTRONIC NOSE AND BIOSENSOR USING THE SAME

선택적 표면 고정화 부위를 갖는 나노갭 트랜스듀서

... 본 발명의 실시양태는 전자 센서 및 산화환원 사이클링 센서로서 기능할 수 있는 트랜스듀서를 제공한다. 트랜스듀서는 나노갭에 의해 이격된 2개의 전극을 포함한다. 나노갭 내에 근접해 있는 분자 결합 영역이 제공된다. 또한, 나노갭 트랜스듀서 및 나노갭 트랜스듀서의 어레이를 제조하는 방법이 제공된다. 개별적으로 어드레싱 가능한 나노갭 트랜스듀서의 어레이가 집적 회로 칩 상에 배치되고 집적 회로 칩에 작동가능하게 결합될 수 있다.

DEVICE FOR SENSING FLUORINE-BASED GAS AND METHOD FOR MANUFACTURING SAME

A device for sensing fluorine-based gas is disclosed. The device for sensing fluorine-based gas comprises: a substrate; and a sensing layer disposed on the substrate and comprising hydrogenated titanium dioxide nanoparticles to change a color thereof when the sensing layer reacts to fluorine-based gas. The device for sensing fluorine-based gas can sense the fluorine-based gas through a color change of the sensing layer. COPYRIGHT KIPO 2016 ...

Composition for Diagnosing Circulating Tumor Cells and Method for Detecting Circulating Tumor Cells Using the Same

전계효과 트랜지스터형 바이오 센서 어레이 제조방법 및 미세유체소자를 포함하는 전계효과 트랜지스터형 바이오 센서 어레이 제조방법

... 전계효과 트랜지스터형 바이오 센서 어레이 제조방법이 개시된다. 전계효과 트랜지스터형 바이오 센서 어레이 제조방법은 기판 상에 2차원 나노재료로 이루어진 채널층을 배치하는 단계; 상기 채널층 상에 희생층을 배치하는 단계; 상기 희생층 상에 제1 포토레지스트를 배치하고 상기 제1 포토레지스트를 노광하여 제1 패턴을 형성하는 단계; 패터닝된 상기 제1 포토레지스트를 마스크로 이용하고 상기 채널층 및 상기 희생층을 식각하여 상기 기판 상에 상기 제1 패턴에 대응하는 복수 개의 나노재료 구조체들을 형성하는 단계; 상기 복수 개의 나노재료 구조체들 상에 제2 포토레지스트를 배치하고 상기 제2 포토레지스트를 노광하여 제2 패턴을 형성하는 단계; 패터닝된 상기 제2 포토레지스트를 마스크로 이용하고 상기 복수 개의 나노재료 구조체의 희생층을 식각하여 상기 복수 개의 나노재료 구조체의 채널층 상에 소스 전극과 드레인 전극이 각각 형성될 영역을 형성하는 단계; 상기 복수 개의 나노재료 구조체의 채널층 상에 소스 전극과 드레인 전극을 각각 형성하는 단계; 상기 기판, 상기 소스 전극 및 상기 드레인 전극을 각각 보호하는 보호층을 배치하는 단계; 및 상기 보호층을 마스크로 이용하고 상기 소스 전극과 상기 드레인 전극 사이의 채널층을 노출시키는 단계를 포함한다.

A method and apparatus for manufacturing hirachical Au nanostructures on an electrode using electroless plating technique

ORGANOPHOSPHORUS COMPOUND GAS SENSOR AND A MANUFACTURING METHOD THEREOF, AND A CHEMICAL GAS SENSOR USING THE SAME AND METHOD USING THE SENSOR, CAPABLE OF RAPIDLY SENSING ORGANOPHOSPHORUS COMPOUND GAS CONTAINED IN THE AIR

PURPOSE: An organophosphorus compound gas sensor and a manufacturing method thereof, and a chemical gas sensor using the same and method using the sensor are provided to improve resettability by reducing a time required for attaching/detaching gas molecule in a room temperature. CONSTITUTION: An organophosphorus compound gas sensor comprises source-drain electrodes(131,132), a substrate(134), and a detecting layer(133). Power is applied to the source-drain electrodes. The source-drain electrodes are formed on the substrate. The detecting layer contains a single carbon nano tube between the source-drain electrodes on the substrate. The source-drain electrodes are formed with palladium metal. Electrode patterns are formed by using a photolithographic method and a liftoff method together. COPYRIGHT KIPO 2012 ...

대규모 분자 전자소자 센서 어레이들을 이용하여 분석물들을 측정하는 방법들 및 장치

... 본 개시물의 다양한 실시형태들에서, 분자 전자소자 센서 어레이 칩은, (a) 집적 회로 반도체 칩; 및 (b) 집적 회로 반도체 칩 상부에 배치된 복수의 분자 전자 센서 디바이스들을 포함하며, 상기 센서 디바이스들의 각각은, (i) 나노갭에 의해 분리된 나노 스케일 소스 및 드레인 전극들의 쌍; (ii) 게이트 전극; 및 (iii) 나노갭에 걸치고 소스 및 드레인 전극들을 접속하는 브릿지 및/또는 프로브 분자를 포함하며, 분자 전자 센서 디바이스들은 전자적으로 어드레스가능한, 제어가능한, 및 판독가능한 센서 픽셀들의 어레이로 조직화된다.

BREATHALYZER SYSTEM CAPABLE OF WIRELESS COMMUNICATIONS

A breathalyzer system capable of wireless communications according to the present invention comprises: a sensing module including an electrode composed of a metal oxide resistor and a nanomaterial and a channel composed of a metal oxide resistor; and a communications module connected to the sensing module and performing wireless communications with a smart terminal, and thus is used more conveniently by allowing a user to check an alcohol measurement result with the smart terminal. In addition, the smart terminal can be used to accumulate and manage data of alcohol measurement results, thereby helping the user control drinking habits in a long term. In addition, since the channel consists of the metal oxide resistor, alcohol concentration can be measured by measuring the change in current upon exposure to the alcohol-based gas, so the user can easily measure the alcohol concentration. COPYRIGHT KIPO 2017 (110) Sensing module (120) Communications module ...

uso de nanosistemas luminescentes para autenticação de documentos de segurança

aparelho para o processamento de sequências de nucleotídeos, método para o processamento de sequências de nucleotídeos, e, uso do aparelho

método de análise fluorescente para detecção e diferenciação da cocaína

Field-effect transistor, single electron transistor, and sensor using same

A sensor for detecting a substance to be detected. The sensor includes a field-effect transistor (1A) having a substrate (2), a source electrode (4) and a drain electrode (5) both installed on the substrate (2), and a channel (6) to serve as a current path between the source electrode (4) and the drain electrode (5). The field-effect transistor (1A) further includes an interaction sensing gate (9) for immobilizing a specific substance (10) interactive selectively with the substance to be detected and a gate (7) to which a voltage is applied so that the interaction is detected as a characteristic variation of the field-effect transistor (1A). Such a structure enables a sensor to detect a substance to be detected with a high detection sensitivity.

APPARATUS AND METHOD FOR MOLECULAR SEPARATION, PURIFICATION, AND SENSING

APPARATUS AND METHOD FOR USING LIGHT TO ADJUST SENSITIVITY OF SILICON NANOWIRE SENSOR

Provided in the present invention are an apparatus and a method for using light to adjust the sensitivity of a silicon nanowire sensor, the apparatus comprising a silicon nanowire sensor used to output a sensitive signal for sensing a target object and convert the sensitive signal into an electrical signal, and a light source used to supply the silicon nanowire sensor with a preset illumination intensity; and an optical power regulator used to regulate the preset illumination intensity and a signal processor for performing signal processing and feedback. In the present apparatus, by means of arranging a power-adjustable light source at the top of a silicon nanowire sensor and changing the illumination conditions surrounding same, a function of adjusting the sensitivity thereof is implemented. In the present method, the varying response sensitivity of a silicon nanowire sensor under different illumination intensities is utilized, and the sensitivity of the sensor is adjusted by means of ...

FABRICATION OF NANOWIRE ARRAYS

The present invention generally relates to nanowire arrays and methods of fabricating such arrays. In certain embodiments, the fabrication methods can consistently form NW arrays with reproducible configurations at nanoscale sites and produce NWs of specified heights, diameters, and densities. In some cases, the methods also allow formation of NW arrays containing barriers between regions, which would be prohibitively expensive if prepared by other methods.

CONTRAST AGENT AND ITS USE FOR IMAGING

The present invention relates to contrast agent enhanced medical ultrasound imaging. In particular, the contrast agents provided are useful for cell imaging and cell therapy, as well as in vivo targeting, drug delivery and perfusion or vascular imaging applications. More specifically, it provides a particle comprising a fluorinated organic compound and a metal. Such particles may be advantageously employed in qualitative or quantitative imaging such as acoustic imaging including photoacoustic and ultrasound imaging, MRI imaging, such as 19F imaging, 1H imaging including T1 and T2 weighted imaging, SPECT, PET, scintigraphy, fluorescence imaging and optical coherence imaging and tomographic applications. This may then be employed in cell labeling, microscopy, histology or for imaging vasculature or perfusion in vivo and in vitro.

VACUUM DEGREE MEASUREMENT SENSOR USING GRAPHENE NANORIBBON

The present invention relates to a vacuum degree measurement sensor using a graphene nanoribbon, which comprises a thin graphene nanoribbon film configured by at least two graphene nanoribbon layers and senses the degree of a vacuum by using a resistance value of each of the graphene nanoribbon layers. A vacuum degree measurement sensor using a graphene nanoribbon according to the present invention uses a graphene nanoribbon and thus has a short cross-sectional distance and a resistance value that significantly changes according to a curved state thereof. Therefore, the vacuum degree measurement sensor has increased sensitivity and allows gas molecules trapped between graphene layers to be diffused in a short distance, so that the sensor can have an increased response speed according to the degree of a vacuum.

SENSOR MEMBRANE FOR THE REVERSIBLE DETECTION OF ANALYTES

In a sensor membrane for the reversible detection of analytes, comprising a polymeric carrier membrane, an indicator dye covalently bonded to the carrier membrane, and optionally a covering layer, a further dye having a different colour from the indicator dye is covalently fixed to the carrier membrane, and the further dye and the indicator dye are covalently bonded to in particular nano- or microparticles different from one another and consisting of cellulose, polyurethane hydrogel, poly(hydroxyethyl methacrylate), amino polymer, polyacrylates, silicones, epoxides, sol gel glasses or polyolefins, and then are embedded into a polymeric carrier membrane or are physically or chemically coupled.

A CHEMIRESISTIVE SUBSTRATE FOR A HYDROGEN GAS SENSOR

The invention provides a chemiresistive substrate for a dihydrogen-sensitive amperometric gas sensor, the chemiresistive substrate comprising: a crystalline semiconductive metal oxide layer comprising an array of spaced apart hollow metal oxide micro-shells protruding from a base plane of the metal oxide layer; and metallic nanoparticles decorating the metal oxide layer.

HYDROLYTICALLY STABLE SELF-HEALING ELASTOMER

The present invention provides a solution-processable self-healing hydrolytically stable elastomer, a method for the preparation thereof, and articles of manufacture comprising the elastomer. The elastomer comprises polymeric chains comprising units of formula (A1), wherein R is a polybutadiene-containing polyurethane; R1 and R1' are independently selected from the group consisting of: —H, (C1-C20)alkyl, (C5-C14)aryl, —OR4, —(CO)R5, —O(CO)R6, —(SO)R7, CO—R8, —COOR9, —NO2, and halogen; R2, R2', R3 and R3' are independently selected from the group consisting of: —H, (C1-C20)alkyl, and (C5-C14)aryl; R4 to R9 are the same or different, and are independently selected from the group consisting of: —H, (C1-C20)alkyl, and (C5-C14)aryl; m is 4; wherein the elastomer is dynamically crosslinked by aromatic disulfide metathesis, and wherein the elastomer has a water contact angle of above 100⁰.

ANALYTE DETECTION METHOD

The present invention provides a method of detecting one or more analytes in a target sample, the method comprising: a. providing a nanoparticle dimer adapted to bind the analyte; b. causing the dimer to pass through a nanopore by voltage-driven translocation; c. observing changes in the translocation current; and d. comparing the translocation current profile of the target sample to the translocation current profile of a control sample; wherein a change in the translocation current profile of the target sample versus the control sample indicates the presence of the analyte in the target sample. Also provided is a method of detecting one or more analytes in a target sample, the method comprising: a. providing a nanoparticle adapted to bind the analyte; b. providing a carrier nucleic acid molecule with at least one single-stranded region; c. contacting the carrier nucleic acid molecule and nanoparticle with the target sample, forming a carrier nucleic acid/analyte/nanoparticle complex; b ...

MAGNETIC-RESONANCE-IMAGING CONTRAST AGENT, METHOD FOR FABRICATION THEREOF, AND APPLICATION THEREOF

Disclosed is a magnetic-resonance-imaging contrast agent, comprising superparamagnetic nanoparticles and hydroxyethyl starch at a mass ratio of 1:5-1:15; the particle diameter of the superparamagnetic nanoparticles is 100-140 nm, and they consist of iron(II,III) oxide particles, citric acid, and poly-D-lysine; the citric acid is attracted to the surface of the iron(II,III) oxide, and the poly-D-lysine is joined to the citric acid by means of an ionic bond; the mass of the citric acid is 6-13% of the mass of the iron(II,III) oxide particles, and the mass of the poly-D-lysine is 8-20% of the mass of the iron(II,III) oxide particles; the magnetic-resonance-imaging contrast agent is a solution or a lyophilized powder. Also disclosed are a method for fabricating the magnetic-resonance-imaging contrast agent, and an application of said contrast agent.

METHOD AND KIT FOR NUCLEIC ACID SEQUENCING

Various embodiments of the present disclosure generally relate to molecular biological protocols, equipment and reagents for the sequencing of long individual polynucleotide molecules.

DETECTION, CAPTURE AND QUATIFICATION OF BIOLOGICAL MOIETIES FROM UNPROCESSED BODILY FLUIDS USING NANOPLASMONIC PLATFORM

A nanoplasmonic platform can be used for the detection and quantification of multiple HIV subtypes in whole blood with localized surface plasmon resonance. Among other things, this nanoplasmonic platform provides a viable way to detection and quantification of viral load at a point of care with significantly less cost, time, and laboratory resources than existing methods of detection. Although an example of HIV detection in whole blood is provided, the nanoplasmonic platform is adaptable to detect other pathogens and infectious agents or macromolecules.

MASSIVELY PARALLEL DNA SEQUENCING APPARATUS

A DNA or genome sequencing structure is disclosed. The structure includes an electrode pair, each electrode having a tip-shaped end, the electrodes separated by a nanogap defined by facing tip-shaped ends; at least one conductive island deposited at or near each tip-shaped end; and a biomolecule having two ends, each end attached to the conductive islands in the electrode pair such that one biomolecule bridges over the nanogap in the electrode pair, wherein nucleotide interactions with the biomolecule provides electronic monitoring of DNA or genome sequencing without the use of a fluorescing element.

ATOMIC NANO-POSITIONING DEVICE

A nano-positioning system for fine and coarse nano-positioning including at least one actuator, wherein the at least one actuator includes a high Curie temperature material and wherein the nano-positioning system is configured to apply a voltage to the at least one actuator to generate fine and/or coarse motion by the at least one actuator. The nano-positioning system being a stand-alone system, a scanning probe microscope, or an attachment to an existing microscope configured to perform a method of creepless nano-positioning that includes positioning a probe relative to a first area of a substrate using coarse stepping and interacting with the first area of the substrate using fine motion after less than 60 seconds of the positioning the probe. The movement of the scanning probe microscope is actuated by a high Curie temperature piezoelectric material that limits and/or eliminates creep, hysteresis and aging.

NANOPARTICLE HAVING A MAGNETIC CORE, POLYMER COATING AND GOLD SHELL, AND METHOD FOR ITS SYNTHESIS

The present disclosure relates to a nanoparticle including a magnetic core, a polymeric coating and a metal shell. The polymeric coating covers the core and is arranged between the magnetic core and the metal shell. The metal shell includes gold and covers the polymeric coating and the metal shell is anisotropic or has an anisotropic shape.

BRIGHTNESS ENHANCEMENT FILM OR CELL WITH QUANTUM-CONFINED SEMICONDUCTOR NANOPARTICLES IN POLYMER DISPERSED LIQUID CRYSTAL

A brightness enhancing film includes a nanostructured polymer dispersed liquid crystal film having quantum-confined semiconductor nanoparticles dispersed throughout. The film may be associated with at least one substrate, wherein the film is disposed on the at least one substrate which may have a micrograting is disposed adjacent the film. The nanoparticles may be in the form of quantum dots, quantum rods or photonic nanocrystals.

METHOD FOR INDUCING PHYSIOLOGICAL ADJUSTMENT USING HIGH DENSITY DISPLAY OF MATERIAL

The present invention relates to a method for adjusting or inducing a specific physiological shape or function by using one or more materials that display on a nano-assembly matrix at a high density inside a cell or a living body. In other words, the present invention relates to a method for effectively physiologically adjusting/inducing specifically inside the cell or the living body effectively, by using the high-density of bioactive materials. The method according to the present invention can arbitrarily induce physiological adjustment inside the cell or the living body by adjusting assembly and disassembly of a nano unit (assembly) matrix, or adjusting display or trapping of a specific material on the nano unit (assembly) matrix.

NANOCOMPOSITE POLYMERS WITH OPTICAL PROPERTIES

The present invention provides nanocomposite polymers useful in a range of applications, including temperature sensing and target analyte detection. The invention further provides certain methods of preparing these nanocomposite polymers using a layer- by-layer approach.

HOMOGENEOUS PERSISTENT LUMINESCENCE NANOCRYSTALS AND METHODS OF PREPARATION AND APPLICATION THEREOF

This invention provides a groundbreaking approach to PLNPs and their preparation. In particular, the synthetic methodology disclosed herein fundamentally differs from the traditional solid-state annealing reactions that require extreme and harsh reaction conditions. In one unique aspect of the invention, a simple, one-step mesoporous template method utilizing mesoporous silica nanoparticles (MSNs) is disclosed that affords in vivo rechargeable NIR-emitting mesoporous PLNPs with uniform size and morphology. In another unique aspect of the invention, the novel synthetic approach is based on aqueous-phase chemical reactions conducted in mild conditions, resulting in uniform and homogeneous PLNPs with desired size control (e.g., sub-10 nm).

PARA-AMINOBENZOIC ACID SENSITIZED TERBIUM DOPED LAF3 NANOPARTICLES FOR DETECTION OF EXPLOSIVE NITRO COMPOUNDS

The patent relates to para amino benzoic acid (pABA) sensitized terbium (Tb3+) doped spherical LaF3 nanoparticles used for detection of nitro group containing compounds using the terbium (Tb3+) doped spherical LaF3 nanoparticles sensitized by para amino benzoic acid (pABA).

ENHANCED PLASMONIC NANOPARTICLES FOR CANCER THERAPY AND DIAGNOSTICS

One or more techniques and/or products are disclosed using a process for preparing metallic nanoparticles. Resulting nanoparticles may comprise a gold-silver-gold core-shell-shell nanoparticles. Such nanoparticles can be formed by forming a gold core, providing certain materials to form a silver shell, and providing certain materials to form a gold shell. The metallic nanoparticles may be used in molecular sensing, catalysis, photothermal therapy, and other biologically-relevant technologies.

APPARATUS FOR MANIPULATING PLASMONS

The present invention provides an apparatus and method for manipulating plasmons. The apparatus comprises a support structure and two or more plasmon-responsive elements. The plasmon-responsive elements are disposed adjacent the support structure and configured for interaction with electromagnetic radiation and generation of a plurality of plasmons. At least a first of the plasmon-responsive elements is configured to manipulate interaction of at least some of the plurality of plasmons with at least a second of the plasmon-responsive elements.

NANOPARTICLES COMPRISING ENZYME-BASED GOLD NANOCLUSTERS, AND METHOD FOR MANUFACTURING SAME

The present invention relates to nanoparticles comprising enzyme-based gold nanoclusters and to a method for manufacturing same, the nanoparticles being formed by the agglomeration of protein-gold nanoclusters and enzyme-gold nanoclusters, and thus being capable of improving stability and sensing sensitivity.

A PLASMONIC NANOANTENNA, PLASMONIC NANOANTENNA SENSOR ARRAYS, AND A METHOD THEREOF

A plasmonic nanoantenna (1000) is disclosed. In a specific embodiment, the plasmonic nanoantenna (1000) includes a main arm (1100) having a first finite length defined by a first main arm end portion (1110) and a second main arm end portion (1120), a secondary arm (1200) having a second finite length defined by a first secondary arm end portion (1210) and a second secondary arm end portion (1220), and an intermediate arm (1300) arranged to be connected to the second main arm end portion (1120) and the second secondary arm end portion (1220). In this embodiment, the first main arm end portion (1110) and the first secondary arm end portion (1210) are arranged to extend in a same direction, and the first finite length is longer than the second finite length. Plasmonic nanoantenna sensor arrays (2000, 3000, 4000) that include the plasmonic nanoantenna (1000) for sensing a molecular vibration are also disclosed. A method of detecting a molecule is also disclosed.

SOLID-STATE NANOPORE MANUFACTURING METHOD AND SENSOR COMPRISING SOLID-STATE NANOPORE

A solid-state nanopore manufacturing method and a sensor comprising a solid-state nanopore. Said manufacturing method comprises the following steps: depositing a SiN layer (14) on one side of a silicon substrate (12); depositing SiO2 layers (16a, 16b) on the SiN layer (14) and the other side of the silicon substrate (12) respectively; preparing an etching resist layer (20) on the SiO2 layer (16a) on said one side, etching the etching resist layer (20) and the SiO2 layer (16a) on said one side to form an etched groove (24a), the etching groove (24a) exposing said one side having the SiN layer (14), and removing the etching resist layer (20) from said one side; preparing an etching resist layer on the SiO2 layer (16b) on said other side, etching the etching resist layer and the SiO2 layer (16b) on said other side to form an etched groove (24b), the etched grooves (24a, 24b) on the two sides being aligned, the etched groove (24b) on said other side exposing the other side having the silicon ...

ULTRAFINE NANOPARTICLES COMPRISING A FUNCTIONALIZED POLYORGANOSILOXANE MATRIX AND INCLUDING METAL COMPLEXES; METHOD FOR OBTAINING SAME AND USES THEREOF IN MEDICAL IMAGING AND/OR THERAPY

The invention relates to novel biocompatible hybrid nanoparticles of very small size, useful in particular for diagnostics and/or therapy. The purpose of the invention is to offer novel nanoparticles which are useful in particular as contrast agents in imaging (e.g. MRI) and/or in other diagnostic techniques and/or as therapeutic agents, which give better performance than the known nanoparticles of the same type and which combine both a small size (for example less than 20 nm) and a high loading with metals (e.g. rare earths), in particular so as to have, in imaging (e.g. MRI), strong intensification and a correct response (increased relaxivity) at high frequencies. The method for the production of these nanoparticles and the applications thereof in imaging and in therapy also form part of the invention.

Manufacturing strain sensitive sensors and/or strain resistant conduits from a metal and carbon matrix

Implementations and techniques for manufacturing strain sensitive sensors and/or strain resistant conduits from a metal and carbon matrix are generally disclosed.

Magnet arrangement for a target backing tube, target backing tube including the same, cylindrical target assembly and sputtering system

The disclosure relates to a magnet arrangement for a sputtering system, wherein the magnet arrangement is adapted for a rotatable target of a sputtering system and includes: a first magnet element extending along a first axis; a second magnet element being disposed around the first magnet element symmetrically to a first plane; wherein the second magnet element includes at least one magnet section intersecting the first plane; and wherein a magnetic axis of the at least one magnet section is inclined with respect to a second plane being orthogonal to the first axis. Further, the disclosure relates to a target backing tube for a rotatable target of a sputtering system, a cylindrical rotatable target for a sputtering system, and a sputtering

Integrated anode and activated reactive gas source for use in a magnetron sputtering device

The invention relates to an integrated anode and activated reactive gas source for use in a magnetron sputtering device and a magnetron sputtering device incorporating the same. The integrated anode and activated reactive gas source comprises a vessel having an interior conductive surface, comprising the anode, and an insulated outer body isolated from the chamber walls of the coating chamber. The vessel has a single opening with a circumference smaller that that of the vessel in communication with the coating chamber. Sputtering gas and reactive gas are coupled through an input into the vessel and through the single opening into the coating chamber. A plasma is ignited by the high density of electrons coming from the cathode and returning to the power supply through the anode. A relatively low anode voltage is sufficient to maintain a plasma of activated reactive gas to form stoichiometric dielectric coatings.

Rotatable sputter target base, rotatable sputter target, coating installation, method of producing a rotatable sputter target, target base connection means, and method of connecting a rotatable target base device for sputtering installations to a target base support

A rotatable target base device for sputtering installations is provided, wherein the target base device is adapted for receiving thereon a solid target cylinder, the rotatable target base device comprising a target base cylinder ( 4 ) having a lateral surface ( 3 ), a middle part ( 12 ), a first end region ( 7 ) and a second end region ( 9 ) opposite to the first end region, wherein at least one of the first and the second end regions has a maximum outer diameter substantially equal to or less than the outer diameter of the middle part.

Automated detection and counting of biomolecules using nanoparticle probes

An apparatus and method for counting nanoparticle probes is disclosed. In one embodiment, quantum dot-tagged proteins on optically transparent membranes or slides are counted. The transparent membranes or slides are loaded onto a stage (e.g., an X-Y stage or X-Y-Z stage), which can automatically reposition the transparent membrane or slides for image capture at varying locations. A microscope can be used for providing a light source to fluoresce the nanocrystals and for providing the magnification needed for image capture. Once one or more images are captured, the nanoparticles can be automatically counted using post-processing software that maintains a total count across multiple images, if desired.

Ion sensor for measuring ion concentration of a solution

An ion sensor includes: a conductive base structure including a substrate and an electrode film formed on the substrate; a plurality of ion-sensitive nanorods protruding from the electrode film; and an encapsulant enclosing the conductive base structure, surrounding the ion-sensitive nanorods, and formed with a window for exposing the ion-sensitive nanorods. Each of the ion-sensitive nanorods has a conductive core and an ion-sensitive layer formed on and enclosing the conductive core. The ion-sensitive material exhibits an ion selectivity of absorbing an ion of interest thereon for inducing a surface potential corresponding to concentration of the ion of interest.

Method for detecting ligand using fret biosensor

The present application relates to a method for detecting ligand using a biosensor applied the FRET(fluorescence resonance energy transfer) phenomenon. More particularly, the method may be used for simply detecting a ligand in a sample by measuring the FRET of a biosensor under the conditions in which a specific critical temperature is maintained. The method may use a phenomenon in which a ligand-binding protein in a biosensor shows reversible unfolding at a temperature higher than the specific critical temperature and the level of the unfolding changes depending on the concentration of a ligand. The method can be widely applied to a variety of kinds of FRET biosensors using the ligand-binding protein.

Imaging Method and Use Thereof

The present invention relates to a method based on atomic force microscopy and the use thereof on biological surfaces. A method is provided to detect the Local Deviational Volume (LDV) of defined subcellular structures irrespective of a biochemical characterisation

Metamaterial Particles for Near-Field Sensing Applications

A method and structure for designing near-field probes with high sensitivity used in detecting a wide variety of materials and objects such as biological anomalies in tissues, cracks on metallic surfaces, location of buried objects, or composition of material such as permittivity and permeability . . . etc., is disclosed. The present invention includes using single or multiple metamaterial unit cells or metamaterial particles as near-field sensors. Metamaterial unit cells are defined as the building blocks used for fabricating metamaterials that provide electrical or magnetic properties not found in naturally occurring media. Metamaterial unit cells or particles include split-ring resonators, complementary split-ring resonators, or a variety of other electrically-small resonators made of conducting wires or conducting flat surfaces. Metamaterial unit cells are excited by appropriate excitations such as small loops, microstriplines, etc. depending on the electromagnetic properties of the metamaterial unit cell. Once the metamaterial unit cell is excited, the reflection and transmission coefficients from the excitation mechanism can be measured.

Rf impedance matching network with secondary dc input

Embodiments of the disclosure may provide a matching network for a physical vapor deposition system. The matching network may include an RF generator coupled to a first input of an impedance matching network, and a DC generator coupled a second input of the impedance matching network. The impedance matching network may be configured to receive an RF signal from the RF generator and a DC signal from the DC generator and cooperatively communicate both signals to a deposition chamber target through an output of the impedance matching network. The matching network may also include a filter disposed between the second input and the output of the impedance matching network.

Luminescent chemical sensor integrated with at least one molecular trap

A luminescent chemical sensor integrated with at least one molecular trap. The luminescent chemical sensor includes at least one molecular trap and at least one metallic-nanofinger device integrated with at least one molecular trap. The molecular trap includes a plurality of electrodes that trap at least one analyte molecule. The metallic-nanofinger device includes a substrate, and a plurality of nanofingers coupled with the substrate. A nanofinger of the plurality includes a flexible column, and a metallic cap coupled to an apex of the flexible column. At least the nanofinger and a second nanofinger of the plurality of nanofingers are to self-arrange into a close-packed configuration with the analyte molecule. A method for using, and a chemical-analysis apparatus including the luminescent chemical sensor are also provided.

Method for detecting an analyte gas using a gas sensor device comprising carbon nanotubes

This invention relates generally to gas sensors comprising organized assemblies of carbon and non-carbon compounds. The invention also relates to devices containing such gas sensors and analysis units. In preferred embodiments, the organized assemblies of the instant invention take the form of nanorods or their aggregate forms. More preferably, a nanorod is made up of a carbon nanotube filled, coated, or both filled and coated by a non-carbon material. The invention further relates to a method for detecting or quantitating an analyte gas.

Method for electric measurement of peroxide using cnt sensor

Disclosed is a method for measuring the concentration of a peroxide using a CNT sensor. The CNT sensor comprises a working electrode that is arranged on an insulating substrate, a monolayered carbon nano-tube that is contacted with the working electrode, a counter electrode, and a reference electrode. A sample is provided on the monolayered carbon nano-tube, and a potential difference is made between the working electrode and the counter electrode. In this manner, the concentration of the peroxide in the sample can be measured. The measurement method can be applied to clinical tests or the like.

Method and apparatus to produce high density overcoats

A deposition system is provided, where conductive targets of similar composition are situated opposing each other. The system is aligned parallel with a substrate, which is located outside the resulting plasma that is largely confined between the two cathodes. A “plasma cage” is formed wherein the carbon atoms collide with accelerating electrons and get highly ionized. The electrons are trapped inside the plasma cage, while the ionized carbon atoms are deposited on the surface of the substrate. Since the electrons are confined to the plasma cage, no substrate damage or heating occurs. Additionally, argon atoms, which are used to ignite and sustain the plasma and to sputter carbon atoms from the target, do not reach the substrate, so as to avoid damaging the substrate.

High density plasma etchback process for advanced metallization applications

A physical vapor deposition (PVD) system and method includes a chamber including a target and a pedestal supporting a substrate. A target bias device supplies DC power to the target during etching of the substrate. The DC power is greater than or equal to 8 kW. A magnetic field generating device, including electromagnetic coils and/or permanent magnets, creates a magnetic field in a chamber of the PVD system during etching of the substrate. A radio frequency (RF) bias device supplies an RF bias to the pedestal during etching of the substrate. The RF bias is less than or equal to 120V at a predetermined frequency. A magnetic field produced in the target is at least 100 Gauss inside of the target.

Sputtering apparatus

A sputtering apparatus includes a target electrode capable of mounting a target, a first support member which supports the target electrode, a magnet unit which forms a magnetic field on a surface of the target, a second support member which supports the magnet unit, and a force generation portion which is provided between the first support member and the second support member, and generates a second force in a direction opposite to a first force that acts on the second support member by an action of the magnetic field formed between the target and the magnet unit, wherein the second force has a magnitude which increases as the magnet unit comes closer to the target electrode.

Quantitation of cellular dna and cell numbers using element labeling

Methods and kits for the quantitation of cellular DNA and cell numbers are provided. Passive element uptake, element-labeled DNA intercalators, and element labeled affinity reagents are used to quantify DNA and cells. The DNA and the cells are analyzed by elemental analysis, including ICP-MS. The methods and kits provide a fast and accurate analysis of cellular DNA and cell numbers.

Substrate cooling device, sputtering apparatus and method for manufacturing electronic device

A substrate cooling device includes: a substrate holding stage including a recess defining a space between a substrate mounting unit and a substrate mounted on the substrate mounting unit; a holding member that exerts a pressing force against the substrate holding stage so as to fix the substrate to the substrate holding stage; a refrigerator connected to the substrate holding stage; a coolant gas inlet path including a coolant gas inlet opening that is provided at the substrate holding stage and opens to a recessed face of the recess, the coolant gas inlet path connecting a space in the recess via the coolant gas inlet opening to a coolant gas supply; and a coolant gas outlet path including a coolant gas outlet opening that is provided at the substrate holding stage independently of the coolant gas inlet opening and opens to the recessed face of the recess.

Method for determining process-specific data of a vacuum deposition process

A method for determining process-specific data of a vacuum deposition process, in which a substrate is coated in a vacuum chamber by a material detached from a target connected to a magnetron, an optical emission spectrum being recorded and process-significant data of the vacuum deposition process being determined therefrom for further processing in measurement or regulating processes, is optimized to minimize errors in the determination of process-significant data. At least three intensities of spectral lines of at least two process materials are determined from the optical emission spectrum. From these, single and multiple intensities are mathematically correlated with and to one another and a process-significant datum, which is used in subsequent measurement or regulating processes, is determined from the relation results by a further mathematical relation.

Systems and methods for neutron detection using scintillator nano-materials

In one embodiment, a neutron detector includes a three dimensional matrix, having nanocomposite materials and a substantially transparent film material for suspending the nanocomposite materials, a detector coupled to the three dimensional matrix adapted for detecting a change in the nanocomposite materials, and an analyzer coupled to the detector adapted for analyzing the change detected by the detector. In another embodiment, a method for detecting neutrons includes receiving radiation from a source, converting neutrons in the radiation into alpha particles using converter material, converting the alpha particles into photons using quantum dot emitters, detecting the photons, and analyzing the photons to determine neutrons in the radiation.

Uniformity tuning capable esc grounding kit for rf pvd chamber

Embodiments of the invention generally relate to a grounding kit for a semiconductor processing chamber, and a semiconductor processing chamber having a grounding kit. More specifically, embodiments described herein relate to a grounding kit which creates an asymmetric grounding path selected to significantly reduce the asymmetries caused by an off center RF power delivery.

Application of quantum dots for nuclear staining

Embodiments of a system, method, and kit for visualizing a nucleus are disclosed. A tissue sample is pretreated with a protease to permeabilize the nucleus, and then incubated with a nanoparticle/DNA-binding moiety conjugate. The DNA-binding moiety includes at least one DNA-binding molecule. The conjugate binds to DNA within the nucleus, and the nanoparticle is visualized, thereby visualizing the nucleus. Computer and image analysis techniques are used to evaluate nuclear features such as chromosomal distribution, ploidy, shape, size, texture features, and/or contextual features. The method may be used in combination with other multiplexed tests on the tissue sample, including fluorescence in situ hybridization. Kits for performing the method include a protease enzyme composition, a nanoparticle/DNA-binding moiety conjugate, and a reaction buffer.

Ultrasensitive Biochemical Sensing Device and Method of Sensing Analytes

Systems and methods biochemically sense a concentration of a ligand using a sensor having a substrate having a metallic nanoparticle array formed onto a surface of the substrate. A light source is incident on the surface. A matrix is deposited over the nanoparticle array and contains a protein adapted to binding the ligand. A detector detects s-polarized and p-polarized light from the reflective surface. Spacing of nanoparticles in the array and wavelength of light are selected such that plasmon resonance occurs with an isotropic point such that −s and −p polarizations of the incident light result in substantially identical surface Plasmon resonance, wherein binding of the ligand to the protein shifts the resonance such that differences between the −S and −P polarizations give in a signal indicative of presence of the ligand.

Manufacturing method and system of target

The disclosed technology provides a manufacturing method of a target comprising obtaining an initial mass and a residual mass of the target sample, and calculating an etching mass; determining a relative etching depth of the target sample; calculating a relative etching mass based on the etching mass and the relative etching depth; determining a utilization parameter of the target sample based on the relative etching mass and the initial mass of the target sample before being used; and performing a simulation and optimization process on the utilization parameter of the target sample, obtaining target parameters corresponding to a preset value of the utilization parameter, and outputting the target parameters to a manufacturing control center for manufacturing a target. The disclosed technology also provides a manufacturing system of a target.

Method of diagnosing, prognosing and monitoring alzheimer's disease

The present invention provides a system and method for diagnosing, monitoring or prognosing Alzheimer's disease using at least one sensor comprising carbon nanotubes coated with cyclodextrin or derivatives thereof and/or at least one sensor comprising metal nanoparticles coated with various organic coatings in conjunction with a learning and pattern recognition algorithm.

Device for the selective detection of benzene gas, method of obtaining it and detection of the gas therewith

Device for the selective detection of benzene gas, which comprises, on a base substrate, a combination of at least one functionalised multi- or single-wall carbon nanotube sensor decorated with rhodium clusters, and at least one functionalised multi- or single-wall carbon nanotube sensor decorated with metal clusters selected from gold, palladium, nickel and titanium, and/or undecorated, where said substrate additionally comprises means for measuring the variation in the resistance of said sensors. The device is useful at ambient temperature in the presence or absence of oxygen and easy to handle. It also relates to a method for the manufacturing thereof and for detecting the gas in the chemical industry, the petrochemical industry, petrol stations, or household, aeronautical or research applications.

Methods for Detection of a Single- or Double-Stranded Nucleic Acid Molecule

The present invention is related to a method for the detection of a nucleic acid molecule comprising at least a strand comprising a sequence of nucleotides in a sample, whereby the method comprises the following steps: providing a sample containing the nucleic acid molecule; providing a capture probe, whereby the capture probe is at least partially complementary to a part of the nucleic acid molecule; allowing the capture probe to react with the nucleic acid molecule or a part thereof; and detecting whether or not the capture probe is hybridized to the nucleic acid molecule or part thereof.

Quantitation of Cellular DNA and Cell Numbers Using Element Labeling

Methods and kits for the quantitation of cellular DNA and cell numbers are provided. Passive element uptake, element-labeled DNA intercalators, and element labeled affinity reagents are used to quantify DNA and cells. The DNA and the cells are analyzed by elemental analysis, including ICP-MS. The methods and kits provide a fast and accurate analysis of cellular DNA and cell numbers.

Dna sequencing employing nanomaterials

Charge transfer doped nanomaterials such as hydrogen terminated diamond, nanotubes, nanowires or similar nanostructures are used to create a highly sensitive pH sensor, or ion sensitive sensor to directly detect the addition of a newly incorporated nucleotide when performing DNA sequencing by synthesis. A single highly integrated chip can be made to sequence many strands of DNA in a massively parallel fashion in a short amount of time with a direct electronic readout that will bring the cost, size, power consumption of sequencing DNA to very attractive and useful levels.

Method of enhanced detection for nanomaterial-based molecular sensors

Sensors based on single-walled carbon nanotubes and graphene which demonstrate extreme sensitivity as reflected in their electrical conductivity to gaseous molecules, such as NO, NO 2 and NH 3 , when exposed to in situ ultraviolet (UV) illumination during measurement of the analytes are disclosed. The sensors are capable of detection limits of NO down to almost 150 parts-per-quadrillion (“ppq”), detection limits of NO 2 to 2 parts-per-trillion (“ppt”), and detection limits of NH 3 of 33 ppt.

Sputter target

In one aspect of the invention, a sputter target is provided comprising a backing plate ( 40 ) comprising a front surface and a back surface; and a sputtering plate mounted on said backing plate, the sputtering plate comprising a sputtering surface and a back surface. At least one of the back surface of the sputtering plate, the front surface of the backing plate, or the back surface of the backing plate has at least one groove ( 30 ) that is shaped and sized to correspond to an observed region of higher sputtering of the sputtering plate relative to an adjacent area of the sputtering plate. An insert ( 50 ) is placed in the groove(s). The backing plate comprises a first material, the sputtering plate comprises a second material, and an insert comprises a third material. In yet another aspect of the sputter target, a method of controlling the electromagnetic properties of a sputter target is provided.

Metallic Nanoparticle Pressure Sensor

An electrical pressure sensor is provided with a method for measuring pressure applied to a sensor surface. The method provides an electrical pressure sensor including a sealed chamber with a top surface, first electrode, second electrode, an elastic polymer medium, and metallic nanoparticles distributed in the elastic polymer medium. When the top surface of the sensor is deformed in response to an applied pressure, the elastic polymer medium is compressed. In response to decreasing the metallic nanoparticle-to-metallic nanoparticle mean distance between metallic nanoparticles, the electrical resistance is decreased between the first and second electrodes through the elastic polymer medium.

Biochip

A biochip including a metal nanoparticle layer on a multilayer substrate can perform qualitative and quantitative analyses simply without a separate tag. A biochip including a metal nanoparticle layer on a multilayer substrate and using a CMOS image sensor can be an economically beneficial biochip reusable and convenient in use by employing a relatively simple detection method without a need of using a separate tag.

Polymer coated sers nanotag

An encapsulated surface enhanced Raman scattering (SERS) tag. The tag includes a metal core and an encapsulant, typically a glass encapsulant. The encapsulant is further derivatized with a polymer.

Diagnosing, prognosing and monitoring multiple sclerosis

The present invention provides a system and method for diagnosing, monitoring or prognosing Multiple Sclerosis at different stages as well as affording the prediction of disease activity and response to a treatment regimen, using at least one sensor comprising carbon nanotubes or metal nanoparticles, each coated with various organic coatings in conjunction with a pattern recognition algorithm.

Biosensor detecting thiol group and method for preparing the biosensor

There is provided a biosensor for detecting a thiol group and a method of manufacturing the biosensor. In detail, in the method, Au nano particles are manufactured by irradiating radiation (Step 1), a PTh-EDOT/ITO film is manufactured by forming a poly(thiophene-co-3,4-ethylenedioxythiophene) (PTh-EDOT) layer on an indium tin oxide (ITO) coated substrate using cyclic voltammetry (CV) (Step 2) (Step 2); and a Au nano particle modified PTh-EDOT/ITO film is manufactured by dispersing the Au nano particles manufactured in Step 1 onto the PTh-EDOT/ITO film manufactured in Step 2 (Step 3).

Method for sensing a chemical

This invention relates to a method for detecting an analyte in a sample. The method comprises the steps of exposing the sample to a transducer having a pyroelectric or piezoelectric element and electrodes which is capable of transducing a change in energy to an electrical signal, the transducer having at least one reagent proximal thereto, the reagent having a binding site which is capable of binding the analyte or a complex or derivative of the analyte, wherein at least one of the analyte or the complex or derivative of the analyte has a label attached thereto which is capable of absorbing the electromagnetic radiation generated by the radiation source to generate energy by non-radiative decay; irradiating the reagent with a series of pulses of electromagnetic radiation, transducing the energy generated into an electrical signal, detecting the electrical signal and the time delay between each pulse of electromagnetic radiation from the radiation source and the generation of the electric signal. The time delay between each of the pulses of electromagnetic radiation and the generation of the electric signal corresponds to the position of the analyte at any of one or more positions at different distances from the surface of the transducer. The label is a nanoparticle comprising polypyrrole or a derivative thereof. The invention also provides a kit suitable for performing this method.

Methods for detecting DNA-binding proteins

There is provided a method for detecting binding of a DNA-binding protein to a target recognition sequence. The method comprises mixing in a reaction buffer a first set of metal nanoparticles, a second set of metal nanoparticles and a DNA-binding protein to form a mixture, and detecting the aggregation state of the mixture of metal nanoparticles. Each set of metal nanoparticles has a conjugated double-stranded DNA molecule having a single-stranded overhang at one end. The single-stranded overhangs of each set of DNA-conjugated metal nanoparticles are complementary to each other such that annealing of the complementary overhangs results in formation of the target recognition sequence that specifically binds the DNA-binding protein. The reaction buffer comprises an ionic species in a concentration sufficient to result in aggregation of the metal nanoparticles upon annealing of the first and second single-stranded overhang.

Method of rapidly detecting microorganisms using nanoparticles

The present invention relates to a method of rapidly detecting microorganisms using nanoparticles, and more particularly to a method and device of rapidly detecting microorganisms by adding, to the microorganisms to be detected, nanoparticles having immobilized thereon an antibody that binds specifically to the microorganisms to be detected, subjecting the mixture to an immune reaction to form a reaction solution, passing the reaction solution through a microorganism-concentrating film to concentrate the microorganisms, capturing microorganisms, which was immune-reacted with the antibody-immobilized nanoparticles, by a microorganism-capturing filtration membrane, and determining the presence and concentration of the microorganisms. The present invention detects microorganisms using nanoparticles having immobilized thereon an antibody that binds specifically to the microorganisms to be detected, so that the presence and concentration of the microorganisms can be determined in a more effective and simpler manner than a conventional detection method, and the inventive method is effective in detecting a small amount of microorganisms owing to high sensitivity.

Method and System for Characterizing or Identifying Molecules and Molecular Mixtures

A system and method for identifying a material passing through a nanopore filter wherein an electrical signal is detected as a result of the passage and that signal is processed in real-time using mathematical and statistical tools to identify the molecule. A carrier molecule is preferably attached to one or more molecule(s) under consideration using a non-covalent bond and the pore in the nanopore filter is sized so that the molecule rattles around in the pore before being discharged without passing through the filter pore. The present invention includes not only a method and system for identifying the molecule(s) under consideration but also a kit for setting up the filter as well as mathematical tools for analyzing the signals from the sensing circuitry for the molecule(s) under consideration. 1. A device for identifying at least one molecule , the device comprising two chambers of buffer separated by a membrane over an aperture having at least one nanometer-scale nanopore channel in the membrane , with an applied potential applied between the two chambers , a single blockade molecule that enters the nanopore channel but does not pass immediately therethrough , remaining in the nanopore channel for a period of time and modulating the nanopore channel , a sensor generating electrical signals associated with the blockading molecule and at least one processor using an algorithm for analyzing the electrical signal to characterize the blockade molecule.2. The device according to claim 1 , wherein the membrane includes a plurality of nanopore-scale nanopore channels.3. The device according to further including a system to externally excite the nanopore-scale nanopore channel.4. The device according to further including a sensor for identifying a binding event in the blockade molecule.5. The device according to further including a selector to read one nanopore channel at a selected time.6. The device claim 1 , according to further including signal processing calibration ...

Ammonia Nanosensors, and Environmental Control System

Embodiments of nanoelectronic sensors are described, including sensors for detecting analytes such ammonia. An environmental control system employing nanoelectronic sensors is described. A personnel safety system configured as a disposable badge employing nanoelectronic sensors is described. A method of dynamic sampling and exposure of a sensor providing a number of operational advantages is described. 1. A nanostructure sensor for sensing an analyte of interest in a sample , comprising:a substrate;a nanostructured element disposed adjacent the substrate;one or more conducting elements in electrical communication with the first nanostructure; andat least one functionalization operatively associated with the nanostructured element, the at least one functionalization configured to provide sensitivity for the analyte of interest.2. A sensor as in claim 1 , wherein the nanostructured element includes a network of carbon nanotubes disposed adjacent the substrate.3. A sensor as in claim 2 , wherein the analyte of interest includes ammonia.4. A sensor as in claim 2 , wherein the at least one functionalization includes an organic recognition material.5. A sensor as in claim 4 , wherein the organic recognition material includes a polymer.6. A sensor as in claim 5 , wherein the polymer includes at least one of a conductive polymer and a semi-conductive polymer.7. A sensor as in claim 4 , wherein the organic recognition material includes PABS.8. A sensor as in claim 4 , wherein the organic recognition material includes a nonionic surfactant.9. A sensor as in claim 4 , wherein the organic recognition material includes glycerol.10. A sensor as in claim 4 , wherein the network includes at least one SWNTs which is stably associated with the organic recognition material prior to formation of the network.11. A sensor as in claim 2 , wherein the at least one functionalization includes an inorganic recognition material.12. A sensor as in claim 2 , wherein the one or more conducting ...

NANO-ELECTRONIC SENSORS FOR CHEMICAL AND BIOLOGICAL ANALYTES, INCLUDING CAPACITANCE AND BIO-MEMBRANE DEVICES

Embodiments of nanoelectronic sensors are described, including sensors for detecting analytes inorganic gases, organic vapors, biomolecules, viruses and the like. A number of embodiments of capacitive sensors having alternative architectures are described. Particular examples include integrated cell membranes and membrane-like structures in nanoelectronic sensors. 1. A sensor , comprising:a substrate;a conductive base disposed adjacent the substrate;a dielectric material covering at least a region of the conductive base;one or more nanostructures disposed adjacent the dielectric material and capacitively coupled to the conductive base; anda top lead electrically communicating to the one or more nanostructures.2. The sensor of claim 1 , wherein the one or more nanostructures comprises a network of carbon nanotubes.3. The sensor of further comprising a functionalization material disposed adjacent the carbon nanotubes.4. A sensor claim 2 , comprising:a substrate;a spaced-apart pair including a first and second conductive lead disposed adjacent the substrate;a dielectric material covering at least a region of at least one conductive lead; andone or more nanostructures disposed adjacent the dielectric material and capacitively coupled to at least one conductive lead.5. The sensor of claim 4 , wherein the one or more nanostructures comprises an electrically-continuous network including a plurality of carbon nanotubes spanning to cover at least a region of each conductive lead which separated from each lead by the dielectric material claim 4 , and wherein neither conductive lead is in contact with the network of carbon nanotubes.6. The sensor of claim 5 , wherein the spaced-apart pair of conductive leads have a characteristic separation gap “g” claim 5 , and wherein the carbon nanotubes have a characteristic length “L” claim 5 , and wherein “L” is significantly greater that “g”.7. The sensor of claim 5 , wherein substantial numbers of nanotubes span the gap so as to have ...

ELECTRONIC DEVICE FOR MONITORING SINGLE MOLECULE DYNAMICS

A single molecule sensing device includes a first electrode, a second electrode and a single-walled carbon nanotube (SWNT) connected to the first and second electrodes. At least one linker molecule having first and second functional groups is functionalized with a sidewall of the SWNT, the at least one linker molecule having the first functional group non-covalently functionalized with a sidewall of the single-walled carbon nanotube. A single sensitizing molecule having at least one functional group is functionalized with the second functional group of the at least one linker molecule. 1. A single molecule sensing device comprising:a first electrode;a second electrode;a conductive channel connected to the first electrode and the second electrode;at least one linker molecule having first and second functional groups, the at least one linker molecule having the first functional group non-covalently functionalized with the conductive channel; anda single sensitizing molecule having at least one functional group, said at least one functional group of the single sensitizing molecule being functionalized with the second functional group of the at least one linker molecule.2. The single molecule sensing device of claim 1 , wherein the conductive channel comprises a single-walled carbon nanotube.3. The single molecule sensing device of claim 1 , wherein the first functional group is a functional group which interacts with the conductive channel through pi-pi stacking.4. The single molecule sensing device of claim 2 , wherein the first functional group is a functional group which interacts with the sidewall of the single-walled carbon nanotube through pi-pi stacking.5. The single molecule sensing device of claim 1 , wherein the single sensitizing molecule having at least one functional group is selected from a group consisting of an enzyme claim 1 , a protein claim 1 , a nucleic acid claim 1 , a ribozyme claim 1 , an aptamer claim 1 , and a polysaccharide.6. The single ...

METHOD FOR DETECTING AND QUANTITATING MULTIPLE SUBCELLULAR COMPONENTS

A method for detecting and quantitating multiple and unique fluorescent signals from a cell sample is provided. The method combines immunohistochemistry and a fluorescent-labeled in situ hybridization techniques. The method is useful for identifying specific subcellular components of cells such as chromosomes and proteins. 1. A method comprising:receiving a cell sample that has been reacted with at least one antibody wherein each antibody binds to a specific cellular component and generates a unique antibody fluorescent signal;wherein said cell sample has further been treated by in-situ hybridization using, at least, a first and a second nucleic acid probe, said first nucleic acid probe is constructed to hybridize with a first target nucleic acid sequence in said cell sample and generate a first unique fluorescent signal and said second nucleic acid probe is constructed to hybridize with a second target nucleic acid sequence in said cell sample and generate a second unique fluorescent signal;capturing at least one image of said reacted and treated cell sample under conditions stimulating generation of said fluorescent signals;detecting and counting said first unique fluorescent signals and said second unique signals and computing a ratio of the count said first unique fluorescent signals and said second unique signals; andidentifying and reporting the presence of a physiological condition based on said ratio.2. The method in accordance with claim 1 , wherein said first target nucleic acid sequence defines a dominant trait and said second target nucleic acid sequence defines a recessive trait.3. The method in accordance with claim 1 , further comprising the employment of said first and/or second nucleic acid probe chosen to hybridize with a break region between rearranged and non-rearranged nucleic acids. This application is a continuation of pending U.S. patent application Ser. No. 13/047002, filed on Mar. 14, 2011, which is a continuation of U.S. patent application ...

Preparation of microfluidic device on metal nanoparticle coated surface, and use thereof for nucleic acid detection

The invention relates to a microfluidic device that utilizes nucleic acid-based detection and a detection system containing the same, as well as a process for preparing the micro fluidic device and for using the same to detect the presence of a target nucleic acid molecule in a sample.

NANOELECTROMECHANICAL TUNNELING CURRENT SWITCH SYSTEMS

A nanoelectromechanical tunneling current switch includes a cantilevered nanofilament including a secured end and an unsecured end and a conductor with a surface substantially perpendicular to a longitudinal axis of the nanofilament when the nanofilament is undeflected. The nanofilament is positioned with respect to the conductor to define a gap between the unsecured end of the nanofilament and the surface of the conductor substantially perpendicular to the longitudinal axis of the nanofilament. The nanofilament and the conductor are electrically connected by a circuit, and a tunneling current is configured to flow from the nanofilament to the surface of the conductor substantially perpendicular to the longitudinal axis of the nanofilament. In other embodiments of the nanoelectromechanical tunneling current switch, an electrically conductive membrane can be utilized in place of, or in addition to, the cantilevered nanofilament. 1. A switch comprising:(i) a cantilevered nanofilament comprising a secured end and an unsecured end;(ii) a conductor with a surface substantially perpendicular to a longitudinal axis of the nanofilament when the nanofilament is undeflected, wherein the nanofilament is positioned with respect to the conductor to define a gap between the unsecured end of the nanofilament and the surface of the conductor substantially perpendicular to the longitudinal axis of the nanofilament; and (a) a tunneling current is configured to flow between the nanofilament and the surface of the conductor substantially perpendicular to the longitudinal axis of the nanofilament; and', '(b) the tunneling current is configured to flow from the nanofilament to the conductor in a direction substantially parallel to the longitudinal axis of the nanofilament when the nanofilament is undeflected., '(iii) a circuit electrically connecting the nanofilament and the conductor, wherein'}2. The switch of claim 1 , wherein the nanofilament is a carbon nanotube.3. The switch of ...

Device and method of manipulating particles

Provided is a device and method of manipulating particles. The device includes: a channel for accommodating an electrolyte solution including particles to be manipulated; an anode and cathode for imposing a direct current (DC) electric field on the channel; metal strip(s) attached to an inner wall of the channel and resulting in induced-charge electroosmosis near a surface of the channel; a DC power supply unit for supplying a DC voltage to the anode and the cathode of the channel; control electrodes on both sides of the metal strip(s) to locally tune the induced-charge electroosmosis on the metal strip(s) regardless of the global electric field across the channel; and a DC power supply unit for supplying a DC voltage to the control electrodes.

NANOMOTORS AND MOTION-BASED DETECTION OF BIOMOLECULAR INTERACTIONS

Techniques and systems are disclosed for detecting biomolecular interactions based on the motion of nanomotors. In one aspect, a method of detecting biomolecular interactions based on a motion of a nanomachine includes functionalizing a nanomachine with a capture probe adapted to interact with biological targets; and detecting a presence of the biological targets in an environment based on a motion of the nanomachine. 1. A method of detecting biomolecular interactions based on a motion of a nanomachine , the method comprising:functionalizing a nanomachine with a capture probe adapted to interact with biological targets; anddetecting a presence of the biological targets in an environment based on a motion of the nanomachine.2. The method of claim 1 , wherein detecting the presence of the biological targets comprises detecting a concentration of the biological targets based on a distance traveled by the functionalized nanomachine.3. The method of claim 1 , wherein detecting the presence of the biological targets in an environment comprises:providing the functionalized nanomachine and nanoparticle tags in the environment to allow the capture probe to form a complex with the nanoparticle tags and the biological targets; anddetecting the complex formation based on the motion of the functionalized nanomachine.4. The method of claim 1 , wherein detecting the complex formation comprises:detecting the motion of the functionalized nanomachine in a nanoparticle-releasing solution, wherein the presence of the released nanoparticle speeds up the motion of the functionalized nanomachine.5. The method of claim 1 , wherein the nanoparticle tags comprise silver nanoparticle tags.6. The method of claim 1 , wherein the nanomachine comprises an anode segment and a cathode segment.7. The method of claim 6 , wherein the anode segment comprises platinum and the cathode comprises gold.8. The method of comprising:wherein the biological targets comprise nucleic acid targets.9. The method of ...

MICROWAVE ACCELERATED ASSAYS

The present invention provides for increasing fluorescence detection in surface assay systems while increasing kinetics of a bioreaction therein by providing low-power microwaves to irradiate metallic materials within the system in an amount sufficient to increase heat thereby affecting the kinetics of a bioreaction therein. 1. A system for shortening the time required to detect or measure the presence of a target molecule in a sample , the system comprising:a metallic material, wherein the metallic material is shaped as particles, nanostructures, islands or colloids;a probe attached to the metallic material for binding with the target molecule in the sample;a sample suspected of containing a target molecule;a source of low power microwave energy that emits energy in the gigahertz frequency range in an amount sufficient to increase the kinetics of a chemical reaction involving at least the binding of the target sample to the probe;a detecting molecule that binds to the target molecule and emits detectably energy when radiated with excitation energy; anda source of excitation energy that emits in the UV to IR range for irradiating the detecting molecule.2. The system according to claim 1 , wherein the metallic material comprises silver or gold.3. The system according to claim 1 , wherein the low power microwave energy is from 30 mwatts to 200 watts.4. The system according to claim 1 , wherein the metallic material is positioned on a substrate.5. The system according to claim 4 , wherein the substrate is glass claim 4 , quartz or a polymeric material.6. The system according to claim 1 , wherein the detecting molecule is an intrinsic fluorophore.7. The system according to claim 1 , wherein the detecting molecule is attached to an extrinsic fluorophore.8. The system according to claim 1 , wherein the metallic material is in the form of a three dimensional matrix claim 1 , wherein metal particles are on the surface of the porous substrate or the metal particles are ...

USE OF NANOPARTICLES FOR LABELLING OIL FIELD INJECTION WATERS

The present invention relates to the development of tracer fluids, more generally, that of aqueous liquids, intended to be injected under pressure in an oil reservoir, for example from an injection well up to a production well. 1. A method of study of a solid medium (i.e. an oil reservoir) by diffusion of a fluid through said solid medium , comprising: having average dimensions comprised, in preferred ascending order, between 20 and 200 nm, 20 and 100 nm, 50 and 100 nm, 60 and 80 nm;', 'detectable by means of one or several S signals at dilutions of less than or equal to 10;', 'adapted to form a stable colloidal suspension in a saline medium;', 'at least a portion of which is constituted of a core and a coating provided with an adjustable hydrophilic-lipophilic balance (HLB) and comprising at least one organic and/or organosilicon component., 'injecting, in this solid medium (diffusion), a liquid (injection liquid) comprising a nanoparticle-based tracer;'}recovering the liquid having diffused;analyzing this liquid having diffused to measure the quantity of tracer by detection of the signal or signals S.2. A method according to claim 1 , wherein the core of the nanoparticles contains:at least one material selected from the group consisting of: the semiconductors, noble metals, fluorides, vanadates or rare earth oxides and their mixtures and/or alloys; i. luminescent entities selected from the group consisting of: the semiconductors, oxides, rare earth fluorides or vanadates, organic fluorescent molecules, transition metal ions, rare earth ions connected, or not, to complexing molecules and/or to molecules allowing for enhancing their absorption and their mixtures and/or alloys;', 'ii. optionally, other entities allowing for modifying the luminescence properties and selected from the group consisting of: noble metal particles and their mixtures and/or alloys;', 'iii. and mixtures of (i) and (ii)., 'or a matrix selected from the group of materials consisting of: ...

KIT FOR DOT IMMUNOGOLD DIRECTED FILTRATION ASSAY AND USE THEREOF

A kit for dot immunogold directed filtration assay including a dot immunogold directed filtration card, a detection probe labeled by nano colloidal gold or latex beads, a negative standard, a positive standard, and a cleaning solution. 114-. (canceled)15. A kit for dot immunogold directed filtration assay , comprising a dot immunogold filtration card , a detection probe labeled by nano colloidal gold or latex beads , a negative standard , a positive standard , and a cleaning solution , wherein the dot immunogold filtration card is a dot immunogold directed filtration card being capable of allowing a sample to be assayed and a probe labeled by colloidal gold to sequentially filtrate along a region covered by a coated probe.16. The kit for dot immunogold directed filtration assay of claim 15 , wherein the dot immunogold directed filtration card consists of four layers of a surface layer claim 15 , a microporous membrane claim 15 , a filtration limiting layer claim 15 , and a water absorbent pad from top to bottom claim 15 , the surface layer is formed of a water nonabsorbent material and has an opening at a central portion thereof claim 15 , the microporous membrane has an affinity for protein molecules claim 15 , at least one kind of probe is coated on the microporous membrane claim 15 , the filtration limiting layer is formed of a water nonabsorbent material and has an opening at a central portion thereof claim 15 , and the opening of the filtration limiting layer corresponds to the coated probe and has a shape fit to that of the coated probe.17. The kit for dot immunogold directed filtration assay of claim 16 , wherein the filtration limiting layer of the dot immunogold directed filtration card is formed of PVC claim 16 , PE claim 16 , PP claim 16 , PS claim 16 , ABS plastic claim 16 , a double side adhesive claim 16 , or a waterproof coating.18. The kit for dot immunogold directed filtration assay of claim 15 , wherein the dot immunogold directed filtration card ...

Method of activation of noble metal for measurement of glucose and associated biosensor electrode

An electrochemical glucose biosensor comprising two electrodes with at least one of electrodes having both a metallic layer and a non-metallic layer in direct contact with the metallic layer. The metallic layer is comprised of a noble metal element. A glucose reactive strip connects the first electrode and the second electrode. 1. An electrochemical glucose biosensor comprising: a metallic layer comprising a noble metal element; and', 'a non-metallic electrically conductive layer disposed in direct contact with the metallic layer;, 'a first electrode comprising a non-conducting and chemically inert substrate having disposed thereon an electrically conductive layer, the electrically conductive layer comprisinga second electrode comprising a non-conducting and chemically inert substrate having disposed thereon an electrically conductive layer, the electrically conductive layer comprising a metallic layer comprising a noble metal element; and a glucose reactive strip connecting the first electrode and the second electrode.2. The electrochemical glucose biosensor of wherein the noble metal element of the first electrode is palladium.3. The electrochemical glucose biosensor of wherein the thickness of the metallic layer comprising noble metal of both the first and second electrodes is between about 10 nanometers and about 10 microns.4. The electrochemical glucose biosensor of wherein the thickness of the metallic layer comprising noble metal of both the first and second electrodes is between about 10 nanometers and about 50 nanometers.5. The electrochemical glucose biosensor of wherein the thickness of the metallic layer comprising noble metal of both the first and second electrodes is between about 20 nanometers and about 30 nanometers.6. The electrochemical glucose biosensor of wherein the thickness of the non-metallic electrically conductive layer is between about 1 nanometer and about 10 nanometers.7. The electrochemical glucose biosensor of wherein the glucose ...

THREE-ELECTRODE LINEAR AND BENDING POLYMERIC ACTUATOR

A polymeric actuator includes a first and a second electrode layer (), both containing electrically conductive material and able to change size in at least one direction of deformation under the action of charge injection or ion intercalation. A solid polymer electrolyte layer () is interposed between the first and the second electrode layer, in which the solid polymer electrolyte layer is electrically insulating and ionically conductive. The actuator is able to deform by the action of the dimensional changes of the first and second electrode layer. The actuator further includes a passive electrode () immersed in the solid electrolyte layer to be electrically insulated relative to the first and second electrode layer, in which the passive electrode is electrically conductive and elastically deformable material, so as to support mechanically the deformations of the actuator induced by the dimensional changes of the first and second electrode layer. 1. A polymeric actuator comprising{'b': 2', '3, 'a first and a second electrode layer (, ), both containing an electrically conductive material and able to change size along at least one direction of deformation as a result of charge injection or ion intercalation, and'}{'b': '4', 'a solid polymer electrolyte layer () interposed between said first and the second electrode layers, where said solid polymer electrolyte layer is an electrical insulator and a ionic conductor,'}where said actuator is able to alter its shape as a result of dimensional changes of the said first and second electrode layers,{'b': '5', 'characterized in that said actuator comprises a passive electrode () immersed in the solid polymer electrolyte layer in order to be electrically insulated with respect to the said first and second electrode layers, where the said passive electrode is made of electrically conductive and elastically deformable material, in order to mechanically comply with deformations of the actuator induced by the dimensional changes ...

Probe having nano-fingers

A probe for use in a sensing application includes an elongate body having a first end and a free end, wherein the first end is to be attached to a support. The probe also includes a plurality of nano-fingers having respective bases and tips, wherein each of the plurality of nano-fingers is attached to the free end and is composed of a flexible material, and wherein the plurality of nano-fingers are collapsed toward each other such that the tips of the plurality of nano-fingers are substantially in contact with each other.

Reagents and methods for phosphorylation/dephosphorylation analyses

Disclosed herein are reagents that include a moiety that includes a metal such as titanium and that readily binds to phosphorylated molecules the reagents also include at least one moiety that produces a signal or that binds to a molecule that produces a signal. The reagent may also include a moiety that binds to a larger molecule or to a surface. Some forms of the reagent include a dendrimer that can simultaneously bind to multiple metal moieties that include a metal such as titanium and multiple moieties that can be used to detected bound molecules. These reagents can be used in detection and/or measurement and/or at least partial purification of phosphorylated molecules. These reagents and methods using them are used to analyze proteins, polypeptides, nucleic acids, phospholipids and the like. They are readily adapted for use in gels, blots, plate based high through put assays and for mass spectrometry.

DEVELOPMENT OF PHOTOSTABLE NEAR-IR CYANINE DYES FOR IN VIVO IMAGING

A compound of structural formula (I): 2. The compound of claim 1 , wherein the biomolecule is a protein claim 1 , a peptide claim 1 , an enzyme substrate claim 1 , a pharmaceutical claim 1 , a ligand claim 1 , a hormone claim 1 , an antibody claim 1 , an antigen claim 1 , a hapten claim 1 , a carbohydrate claim 1 , an oligosaccharide claim 1 , a polysaccharide claim 1 , a nucleic acid claim 1 , a fragment of DNA or a fragment of RNA.3. The compound of claim 2 , wherein the ligand is lipoic acid.4. The compound of claim 1 , wherein R is (C-C) branched or straight-chain alkyl claim 1 , (C-C)cycloalkyl claim 1 , (C-C)heterocyclyl claim 1 , (C-C)aryl claim 1 , (C-C)heteroaryl claim 1 , (C-C)aryl(C-C)alkyl claim 1 , (C-C)alkoxy(C-C)alkyl claim 1 , (C-C)heterocyclylalkyl claim 1 , (C-C)cycloalkyl(C-C)alkyl claim 1 , (C-C)bicycloheteroaryl(C-C)alkyl claim 1 , amino(C-C)alkyl claim 1 , (C-C)alkylamino(C-C)alkyl or (C-C)dialkylamino(C-C)alkyl and is optionally substituted with one or more substituents selected from the group consisting of halogen claim 1 , (C-C)alkoxy claim 1 , hydroxy claim 1 , (C-C)aryl claim 1 , (C-C)heteroaryl claim 1 , (C-C)alkyl and nitro.7. The compound of claim 1 , wherein Ris methyl and p is 1.8. The compound of claim 1 , wherein one of R claim 1 , Rand Ris —(CH)L claim 1 , —(CHCHO)L claim 1 , —(CHCHS)L claim 1 , —(CHCHNR)L claim 1 , —(CH)L′-B claim 1 , —(CHCHO)L′-B claim 1 , —(CHCHS)L′-B or —(CHCHNR)L′-B.9. The compound of claim 1 , wherein L is amino claim 1 , hydroxyl claim 1 , thio claim 1 , haloalkyl claim 1 , N-hydroxy succinimidyl ester claim 1 , sulfonato-N-hydroxy succinimidyl ester claim 1 , thiocyanato claim 1 , isothiocyanato claim 1 , nitrophenolyl claim 1 , iodoacetamidyl claim 1 , maleimidyl claim 1 , carboxyl claim 1 , thioacetyl claim 1 , sulfonato or phosphoramidityl.10. The compound of claim 9 , wherein L is amino claim 9 , N-hydroxy succinimidyl ester or sulfonato-N-hydroxy succinimidyl ester.11. The compound of claim 1 , wherein ...

Novel Phosphorylation of Cardiac Troponin I as a Monitor for Cardiac Injury

This invention relates to novel phosphorylation sites in cardiac Troponin I that are associated with the onset of heart failure. The phosphorylation sites, i.e., serine 5, tyrosine 26, threonine 51, serine 166, threonine 181 and/or serine 199, can be used as biomarkers for (i) identifying subjects at risk for the development of heart failure, (ii) treating subjects having a higher than normal level of the biomarker, and (iii) monitoring therapy of a subject at risk for the development of heart failure. Also described are antibodies, reagents, and kits for carrying out a method of the present invention. 1. An antibody that specifically recognizes phosphorylated serine 5 , tyrosine 26 , threonine 51 , serine 166 , threonine181 and/or serine 199 in cardiac Troponin I.2. The antibody of claim 1 , wherein the antibody is a monoclonal antibody.3. The antibody of claim 1 , wherein the antibody is a polyclonal antibody.4. The antibody of claim 1 , wherein the antibody is labeled.5. The antibody of claim 4 , wherein the label is a fluorescent label claim 4 , a moiety that binds another reporter ion claim 4 , a heavy ion claim 4 , a gold particle claim 4 , or a quantum dot.6. A kit for identifying a subject at risk for developing heart failure claim 4 , comprising at least one agent that detects the phosphorylation state of a cardiac Troponin I protein at serine 5 claim 4 , tyrosine 26 claim 4 , threonine 51 claim 4 , serine 166 claim 4 , threonine181 and/or serine 199.7. The kit of claim 6 , wherein the agent is an antibody that recognizes the phosphorylation state of serine 5 claim 6 , tyrosine 26 claim 6 , threonine 51 claim 6 , serine 166 claim 6 , threonine181 and/or serine 199.8. The kit of claim 6 , wherein the agent is an antibody that recognizes un- claim 6 , mono claim 6 , di- claim 6 , and/or tri-phosphorylated serine 5 claim 6 , tyrosine 26 claim 6 , threonine 51 claim 6 , serine 166 claim 6 , threonine181 and/or serine 199.9. The kit of claim 6 , wherein the ...

Particle matrix for storage of biomolecules

Matrices for manipulation of biopolymers, including the separation, purification, immobilization and archival storage of biopolymers is disclosed.

MULTI-LEG LUMINESCENT NANOPARTICLES, MULTI-LEG LUMINESCENT NANOPARTICLE COMPOUNDS AND VARIOUS APPLICATIONS

Multi-leg luminescent nanoparticles (“MLN's”) that can be paired to other MLN's as well s biological molecules to film branched multi-leg luminescent nanoparticles (“BMLN's) that can be used in biological multiplexing applications, imaging applications, biological detection applications and other biological applications. 1. A multi-leg luminescent nanoparticle , comprising:one or more legs extending from a base wherein the one or more legs and the base comprise a luminescent semiconductor nanoparticle;a shell that coats the one or more legs and the base; anda pairing moiety connected to the shell coated one or more legs and base, and configured to connect to an targeting molecule.2. The nanoparticle of claim 1 , wherein the base and one or more legs are a semiconductor or a III-V semiconductor.3. The nanoparticle of claim 2 , wherein the base and one or more legs are a II-VI semiconductor.4. The nanoparticle of claim 2 , wherein the base and one or more legs are a semiconductor.5. The nanoparticle of claim 3 , wherein the semiconductor is MgS claim 3 , MgSe claim 3 , MgTe claim 3 , CaS claim 3 , CaSe claim 3 , CaTe claim 3 , SrS claim 3 , SrSe claim 3 , SrTe claim 3 , BaS claim 3 , BaSe claim 3 , BaTe claim 3 , ZnS claim 3 , ZnSe claim 3 , ZnTe claim 3 , CdS claim 3 , CdSe claim 3 , CdTe claim 3 , HgS claim 3 , HgSe claim 3 , or HgTe.6. The nanoparticle of claim 4 , wherein the semiconductor is GaAs claim 4 , InGaAs claim 4 , InP claim 4 , or InAs.7. The nanoparticle of claim 1 , wherein the shell semiconductor is a II-VI semiconductor or a III-V semiconductor.8. The nanoparticle of claim 7 , wherein said shell is a II-VI semiconductor or a III-V semiconductor.9. The nanoparticle of claim 8 , wherein the semiconductor is MgS claim 8 , MgSe claim 8 , MgTe claim 8 , CaS claim 8 , CaSe claim 8 , CaTe claim 8 , SrS claim 8 , SrSe claim 8 , SrTe claim 8 , BaS claim 8 , BaSe claim 8 , BaTe claim 8 , ZnS claim 8 , ZnSe claim 8 , ZnTe claim 8 , CdS claim 8 , CdSe claim 8 , ...

Film formation apparatus and film formation method

A film formation apparatus of the present invention has two sputtering evaporation sources each of which includes an unbalanced magnetic field formation means formed by an inner pole magnet arranged on the inner side and an outer pole magnet arranged on the outer side of this inner pole magnet, the outer pole magnet having larger magnetic line density than the inner pole magnet, and a target arranged on a front surface of the unbalanced magnetic field formation means, and further has an AC power source for applying alternating current whose polarity is switched with a frequency of 10 kHz or more between the targets of the two sputtering evaporation sources so as to generate discharge between both the targets and perform film formation.

Real-time redox sequencing

Real time redox sequencing methods, devices, and systems are described. Arrays of redox devices comprising one or two electrodes are used to provide sequence information about a template nucleic acid in a polymerase-template complex bound proximate to the electrode(s). A sequencing reaction mixture comprising nucleotide analogs comprising redox labels is introduced to the array of redox devices under conditions of polymerase mediated nucleic acid synthesis. The time sequence of incorporation of nucleotide analogs is determined by electrochemically identifying the redox labels of the nucleotide analogs that are incorporated into the growing strand.

QUANTUM DOT-BASED OPTICAL SENSORS FOR RAPID DETECTION AND QUANTITATIVE ANALYSIS OF BIOMOLECULES AND BIOLOGICAL MATERIALS

The invention generally relates to detection and analysis of biological materials. In particular; the invention relates to quantum dot-based optical, sensors and methods for rapid detection and quantitative analysis of various biomolecules and biological materials, such as nucleic acids, proteins, cells, etc. 1. An optical biomolecular sensor for detecting a target biological material , comprising:(a) an inorganic semiconductor nanocrystal capable of fluorescing at a pre-selected wavelength range upon excitation, wherein the semiconductor nanocrystal has a surface allowing aqueous solubility of the semiconductor nanocrystal;(b) a biomolecular probe having an affinity to the target biological material; and(c) a linkage moiety associated with the semiconductor nanocrystal and with the biomolecular probe such that binding of the biomolecular probe with the target biological material results in an optically detectable change in the fluorescence emission spectrum of the semiconductor nanocrystal without employing a second fluorophore other than the semiconductor nanocrystal.2. The optical biomolecular sensor of claim 1 , wherein the optically detectable change in the fluorescence emission spectrum of the semiconductor nanocrystal comprises a change in the fluorescence emission intensity claim 1 , a change in the blinking rate of the emitted light or a shift in the peak emission wavelength.3. The optical biomolecular sensor of claim 1 , wherein a single biomolecular probe is linked to a single semiconductor nanocrystal.4. The optical biomolecular sensor of claim 1 , wherein the semiconductor nanocrystal is single crystalline ZnSe.5. The optical biomolecular sensor of claim 1 , wherein the semiconductor nanocrystal is single crystalline ZnSe doped with ions selected from the group consisting of Cr claim 1 , Mn claim 1 , Fe claim 1 ,Co claim 1 , Ni claim 1 , and Cu.6. The optical biomolecular sensor of claim 5 , wherein the semiconductor nanocrystal. is single crystalline ...

DEVICE AND METHODS OF DETECTION OF AIRBORNE AGENTS

Provided are methods, devices and systems that utilize free-surface fluidics and SERS for analyte detection with high sensitivity and specificity. The molecules can be airborne agents, including but not limited to explosives, narcotics, hazardous chemicals, or other chemical species. The free-surface fluidic architecture is created using an open microchannel, and exhibits a large surface to volume ratio. The free-surface fluidic interface can filter interferent molecules, while concentrating airborne analyte molecules. The microchannel flow enables controlled aggregation of SERS-active probe particles in the flow, thereby enhancing the detector's sensitivity. 152-. (canceled)53. A system comprising: a flowing or non-flowing fluid;', 'one or more free-surface interface regions that are open on at least one side to atmospheric air, wherein the fluid is located in a channel on the one or more free-surface interface regions, and wherein at least a portion of the fluid is exposed to atmospheric air so that one or more analytes from a sample can come into contact with the surface of the fluid and be absorbed into the fluid;, 'a microfluidic device comprisingmeans for detecting the presence of the one or more analytes absorbed in the fluid.54. The system of claim 53 , wherein the fluid is a non-flowing fluid.55. The system of claim 53 , wherein the means detects the presence of one or more analytes absorbed in the fluid by a technique selected from the group consisting of Raman spectroscopy or surface enhanced Raman scattering (“SERS”) measurements on a probe fixed to one or more walls of the channel or a probe that is contained in the fluid claim 53 , electrochemical analysis techniques claim 53 , fluorescent chemical marker techniques claim 53 , fluorescence quenching claim 53 , redox-labeled nucleic acid binding techniques including but not limited to the molecules DNA claim 53 , RNA and PNA claim 53 , X-Ray absorption techniques claim 53 , IR claim 53 , visible claim ...

KIT INCLUDING SEQUENCE SPECIFIC BINDING PROTEIN AND METHOD AND DEVICE FOR DETERMINING NUCLEOTIDE SEQUENCE OF TARGET NUCLEIC ACID

Provided are kits for determining a nucleotide sequence of a target nucleic acid, the kit including at least one sequence specific binding protein and a detectable tag. In accordance with a kit for determining a nucleotide sequence of a target nucleic acid according to one exemplary embodiment and a method and device for determining a nucleotide sequence of a target nucleic acid, the nucleotide sequence of the target nucleic acid may be more efficiently determined. 1. A kit for determining a nucleotide sequence of a target nucleic acid comprising: at least one sequence specific binding protein and a detectable tag.2. The kit of claim 1 , wherein the target nucleic acid has a length of 1 kb to 10 Mb.3. The kit of claim 1 , wherein the target nucleic acid is double stranded.4. The kit of claim 1 , wherein the sequence specific binding protein comprises at least one motif selected from the group consisting of a zinc finger motif claim 1 , a helix-turn-helix motif claim 1 , a helix-loop-helix motif claim 1 , a leucine zipper motif claim 1 , a nucleic acid-binding motif of restriction endonuclease claim 1 , and a combination thereof.5. The kit of claim 1 , wherein the detectable tag comprises at least one selected from the group consisting of a colored bead claim 1 , a chromophore claim 1 , a fluorescent material claim 1 , a fluorescent protein claim 1 , a phosphorescent material claim 1 , an electrically detectable molecule claim 1 , a molecule providing modified fluorescence-polarization or modified light-diffusion claim 1 , a quantum dotand a combination thereof.6. The kit of claim 5 , wherein the fluorescent protein is selected from the group consisting of a yellow fluorescent protein (YFP) claim 5 , a green fluorescent protein (GFP) claim 5 , a red fluorescent protein (RFP) and a combination thereof.7. The kit of claim 1 , wherein the detectable tag is linked to the sequence specific binding protein by a linker.8. A gene construct comprising a polynucleotide ...

Methods. particles, and assay kits for identifying presence of biological parameters

Multiplexed assays are disclosed for detection of duster differentiation 4 (CD4) glycoprotein expressed on the cell surface of I-helper cells, monocytes, macrophages, and dendritic cells; cluster differentiation 25 (CD25), a type transmembrane protein present on activated T-cells, activated B-cells, thymocytes, myeloid precursors, and oligodendrocytes; and Forkhead box P3 (FOXP3), an intracellular protein involved in immune system responses in cell cultures, tissues samples, humans, and biological samples. The multiplexed assays can be used to detect 1r-cells, activated I-cells, and other similar cell types (e.g. natural T regulatory cells, adaptive/induced T regulatory T cells). The multiplexed assays employ quantum dots of various shapes, types, compositions, coatings, sizes, ligands and other such characteristics.

Simultaneous synthesis of temperature-tunable peptide and gold nanoparticle hybrid spheres

The present invention relates to a novel synthesis of peptide-gold nanoparticle hybrid spheres comprising a step of forming a hybrid structure by inducing self-assembly of a gold-binding peptide, and forming a gold nanoparticle in the structure at the same time. According to the present invention, size of the structure can be controlled according to temperature, and it can be used for various biomedical and electronic applications using the structure.

PIEZOELECTRIC DEVICE OF POLYMER

The present invention relates to a piezoelectric device of a multi-layered structure on which first electrodes and second electrodes are sequentially stacked on a piezoelectric polymer and single surfaces or both surfaces of piezoelectric polymer. 1. A piezoelectric device with a multi-layered structure , comprising:a piezoelectric polymer; anda plurality of first electrodes and a plurality of second electrodes stacked sequentially a single surface or both surface of the piezoelectric polymer.2. The piezoelectric device according to claim 1 , wherein the piezoelectric polymer is polyvinylidene fluoride (PVDF) and polyvinylidene florodide-trifluoroethylene (PVDF-TrFE).3. The piezoelectric device according to claim 1 , wherein the first electrodes are graphene or a graphene composite including the same.4. The piezoelectric device according to claim 3 , wherein the graphene composite is made of a material obtained by mixing the graphene with at least one type material selected from a group consisting of a metal nano wire claim 3 , a metal nano particle claim 3 , a carbon nano tube and conductive polymer.5. The piezoelectric device according to claim 1 , wherein the second electrodes are transparent electrodes or opaque electrodes.6. The piezoelectric device according to claim 5 , wherein the transparent electrode is a grid electrode.7. The piezoelectric device according to claim 5 , wherein the opaque electrodes are obtained by coating metal on a whole surface.8. The piezoelectric device according to or claim 5 , wherein the metal is at least one powder claim 5 , a nano wire or a nano particle selected from a group consisting of Au claim 5 , Cu claim 5 , Al and Ag.9. The piezoelectric device according to claim 1 , further comprises:a plurality of third electrodes on the second electrodes.10. The piezoelectric device according to claim 9 , wherein the third electrodes are graphene or graphene composites including the same.11. The piezoelectric device according to claim ...

METHODS FOR IDENTIFYING DRUG RESISTANT MYCOBACTERIUM

Presented herein are methods for determining the presence of a non-mutated rpoB gene core region. For example, presented herein are methods that permit the determination of whether a is rifampin-resistant by determining whether or not the rpoB gene core region comprises a mutation. In accordance with such methods, multi-drug-resistant strains of also can be identified. 1Mycobacterium. A method for determining the presence of a non-mutated rpoB gene core region , comprising:(a) contacting a nucleic acid sample with a composition comprising a set of probes, wherein at least four probes are rpoB probes that are specific for a non-mutated rpoB gene core region, under conditions that allow hybridization of the rpoB probes to the core region, and wherein the first and third rpoB probes are labeled with a fluorescent donor moiety and the second and fourth rpoB probes are labeled with different fluorescent acceptor moieties, and wherein the rpoB probes hybridize to the non-mutated rpoB gene core region so that the fluorescent acceptor moieties can accept the transfer of energy from the fluorescent donor moieties; and(b) assaying for the presence of fluorescence emission that results when both donor moieties transfer energy to both acceptor moieties, wherein the presence of the fluorescence emission that results when both donor moieties transfer energy to both acceptor moieties indicates the presence of a non-mutated rpoB gene core region, and wherein the absence of or reduction in the fluorescence emission that results when both donor moieties transfer energy to both acceptor moieties indicates the absence of a non-mutated rpoB gene core region.2. (canceled)3MycobacteriumMycobacterium tuberculosis, Mycobacterium africanum, Mycobacterium bovis, Mycobacterium bovisMycobacterium microti.. The method of claim 1 , wherein the is BCG claim 1 , or4MycobacteriumMycobacterium. The method of claim 1 , wherein the presence of a non-mutated rpoB gene core region indicates that the is ...

Thin film manufacturing method, thin film manufacturing device, and liquid crystal display device manufacturing method

Provided is a thin film manufacturing method which is capable of reducing foreign matters to be adhered to a substrate in number while lowering the arcing count. The thin film manufacturing method involves placing a magnet unit ( 5 ) which includes a first magnet ( 51 ) and a second magnet ( 52 ). The first magnet ( 51 ) has a first polarity on its top face which is opposed to a target ( 94 ). The second magnet ( 52 ) has a second polarity on its top face and is arranged around the first magnet ( 51 ). The method also involves reducing a closest distance between an edge ( 52 a ) of the magnet unit ( 5 ) and an edge ( 94 a ) of the target ( 94 ) in a Y-direction as an amount of the target ( 94 ) used increases.

Pressure sensor having nanostructure and manufacturing method thereof

The present disclosure relates to a pressure sensor having a nanostructure and a method for manufacturing the same. More particularly, it relates to a pressure sensor having a nanostructure attached on the surface of the pressure sensor and thus having improved sensor response time and sensitivity and a method for manufacturing the same. The pressure sensor according to the present disclosure having a nanostructure includes: a substrate; a source electrode and a drain electrode arranged on the substrate with a predetermined spacing; a flexible sensor layer disposed on the source electrode and the drain electrode; and a nanostructure attached on the surface of the flexible sensor layer and having nanosized wrinkles.

ELECTRON MULTIPLIER DETECTOR FORMED FROM A HIGHLY DOPED NANODIAMOND LAYER

A system for detecting electromagnetic radiation or an ion flow, including an input device for receiving the electronic radiation or the ion flow and emitting primary electrons in response, a multiplier of electrons in transmission, for receiving the primary electrons and emitting secondary electrons in response, and an output device for receiving the secondary electrons and emitting an output signal in response. The electron multiplier includes at least one nanocrystalline diamond layer doped with boron in a concentration of higher than 5·10cm. 116-. (canceled)17. A system for detecting an electromagnetic radiation or an ion flow , comprising:an input device, for receiving the radiation or an ion flow and emitting primary electrons in response;a multiplier of electrons in transmission for receiving the primary electrons and emitting secondary electrons in response; andan output device, for receiving the secondary electrons and emitting an output signal in response,{'sup': 19', '−3, 'wherein the electron multiplier comprises at least one nanocrystalline diamond layer doped with boron in a concentration of higher than 5·10cm.'}18. A detection system according to claim 17 , wherein the nanocrystalline diamond layer has a boron doping concentration higher than 2·10cm.19. A detection system according to claim 17 , wherein the thickness of the nanocrystalline diamond layer is between 0.1 μm and 10 μm.20. A detection system according to claim 17 , wherein the nanocrystalline diamond layer is formed by chemical vapour deposition.21. A detection system according to claim 17 , wherein the nanocrystalline diamond layer comprises an upstream face for receiving incident electrons claim 17 , and a downstream face for emitting secondary electrons in response claim 17 , the upstream face comprising a hole collection electrode configured to be taken to an electrical potential.22. A detection system according to claim 21 , wherein the collection electrode is situated at an edge of ...

Optical reporter compositions

This invention provides compositions that have a light emitting reporter linked to biomolecules, preferably, nucleotide oligomers. The light reporter particles are silylated and functionalized to produce a coated light reporter particle, prior to covalently linking the biomolecules to the light reporter particle. The light reporter particles of the invention can be excited by a light excitation source such as UV or IR light, and when the biomolecule is DNA, the attached DNA molecule(s) are detectable by amplification techniques such as PCR.

ELECTRODE PATTERN OF TOUCH PANEL AND FORMING METHOD FOR THE SAME

The present invention relates to an electrode pattern of a touch panel and a forming method of the electrode pattern of a touch panel. The electrode pattern of a touch panel according to the present invention includes a plurality of electrode pattern cells which are arranged on a substrate in a space, a dielectric layer formed on the electrode pattern cell, and a bridge electrode which is formed on the dielectric layer by using conductive material of black color and connects the electrode pattern cells. 1. A forming method of an electrode pattern of a touch panel , comprising:forming a plurality of electrode pattern cells formed to each other in a space on a substrate;forming a dielectric layer on the electrode pattern cell; andforming a bridge electrode which is formed on the dielectric layer by using conductive material of black color and connects the electrode pattern cells.2. The forming method of an electrode pattern of a touch panel of claim 1 , wherein the bridge conductive is formed with a metal oxide claim 1 , nitride or fluoride as a blackened metal material.3. The forming method of an electrode pattern of a touch panel of claim 1 , wherein the bridge conductive is blackened claim 1 , corresponding to the luminosity of the substrate claim 1 , the electrode pattern cell or the dielectric layer.4. The forming method of an electrode pattern of a touch panel of claim 2 , wherein the metal material is one of Al claim 2 , Au claim 2 , Ag claim 2 , Sn claim 2 , Cr claim 2 , Ni claim 2 , Ti and Mg.5. The forming method of an electrode pattern of a touch panel of claim 1 , wherein the bridge conductive is formed with Carbon Nano Tube.6. The forming method of an electrode pattern of a touch panel of claim 1 , wherein the bridge conductive is formed as a plurality of layers formed by using a plurality of conductive materials.7. The forming method of an electrode pattern of a touch panel of claim 6 , wherein among the plurality of layers of the bridge conductive claim ...

System and Method for Aligning Sputter Sources

Embodiments provided herein describe systems and methods for aligning sputtering sources, such as in a substrate processing tool. The substrate processing tool includes at least one sputtering source and a device. Each of sputtering sources includes a target having a central axis. The device has an axis and is detachably coupled to the at least one sputtering source. The device indicates to a user a direction in which the central axis of the target of the at least one sputtering source is oriented.

Pacemakers and pacemaker electrodes

A pacemaker is provided. The pacemaker includes an electrode line having a lead and an electrode. The electrode includes a carbon nanotube composite structure having a matrix and at least one carbon nanotube structure located in the matrix. A first end of each carbon nanotube structure protrudes out of a first surface of the matrix for stimulating the human tissue, and a second end of each carbon nanotube structure protrudes out of a second surface of the matrix to electrically connect to the lead.

System and method for sensing intraocular pressure

Systems and methods of sensing intraocular pressure are described. In one embodiment, a miniaturized IOP monitoring system is provided using a nanophotonics-based implantable IOP sensor with remote optical readout that can be adapted for both patient and research use. A handheld detector optically excites the pressure-sensitive nanophotonic structure of the IOP-sensing implant placed in the anterior chamber and detects the reflected light, whose optical signature changes as a function of IOP. Optical detection eliminates the need for large, complex LC structures and simplifies sensor design. The use of nanophotonic components improves the sensor's resolution and sensitivity, increases optical readout distance, and reduces its size by a factor of 10-30 over previously reported implants. Its small size and convenient optical readout allows frequent and accurate self-tracking of IOP by patients in home settings. Embodiments can also be used to monitor colonies of animals to support glaucoma research and drug discovery.

ELECTRICAL-MECHANICAL COMPLEX SENSOR FOR NANOMATERIALS

Disclosed is an electrical-mechanical complex sensor for nanomaterials, including: a detector having a piezoelectric film therein, for measuring a mechanical property of a nanomaterial when a bending or tensile load is applied to the nanomaterial; a first detection film formed at an end of the detector to measure the mechanical property and an electrical property of the nanomaterial) in real time at the same time, when the nanomaterial contacts the first detection film; and a support to which one end of the detector is integrally connected, for supporting the detector. 1. An electrical-mechanical complex sensor for nanomaterials , comprising:{'b': 20', '35', '35, 'a detector () having a piezoelectric film therein, for measuring a mechanical property of a nanomaterial () when a bending or tensile load is applied to the nanomaterial ();'}{'b': 21', '20', '35', '35', '21, 'i': a', 'a, 'a first detection film () formed at an end of the detector () to measure the mechanical property and an electrical property of the nanomaterial () in real time at the same time, when the nanomaterial () contacts the first detection film (); and'}{'b': 10', '20', '20, 'a support () to which one end of the detector () is integrally connected, for supporting the detector (),'}{'b': 10', '11', '14', '35', '15', '21', '21', '35, 'i': b', 'a, 'wherein the support () comprises first to fourth electrodes ( to ) constituting a Wheatstone bridge circuit to measure the load applied to the nanomaterial (), and a fifth electrode () haying a second detection film () at an end thereof to be connected to a first detection film (), for measuring an electrical property of the nanomaterial ().'}220222324232224. The electrical-mechanical complex sensor of claim 1 , wherein the detector () has a structure in which a silicon oxide film () claim 1 , an Au layer () claim 1 , a piezoelectric film () formed of a piezoelectric material claim 1 , an Au layer () claim 1 , and a silicon oxide film () are laminated ...

PHOTONIC CRYSTAL FIBER SENSOR

A method for sensing, a photonic crystal fiber, a method for fabricating a photonic crystal fiber sensor, and a Surface Enhanced Raman Scattering (SERS) sensing apparatus. The method for sensing comprises the steps of providing a photonic crystal fiber comprising a hollow core and a plurality of cladding holes around the hollow core; providing Surface Enhanced Raman Scattering (SERS) active nanoparticles; and adapting the SERS active nanoparticles and/or the fiber for SERS sensing. 123-. (canceled)24. A method for sensing , the method comprising the steps of:providing a photonic crystal fiber comprising a hollow core and a plurality of cladding holes around the hollow core;providing Surface Enhanced Raman Scattering (SERS) active nanoparticles; andadapting the SERS active nanoparticles and/or the fiber for SERS sensing, wherein adapting the SERS active nanoparticles and/or the fiber for SERS sensing comprises controllably immobilising one or more layers of the SERS active nanoparticles on respective inner surfaces of the hollow core and cladding holes.25. The method as claimed in claim 24 , wherein immobilising the one or more layers of the SERS active nanoparticles on respective inner surfaces of the hollow core and cladding holes comprises:charging the respective inner surfaces of the hollow core and cladding holes; anddepositing the SERS active nanoparticles on the charged surfaces.26. The method as claimed in claim 24 , wherein immobilising the one or more layers of the SERS active nanoparticles on respective inner surfaces of the hollow core and cladding holes comprises using a di-thiol linker molecule to link adjacent layers of the nanoparticles.27. The method as claimed in claim 24 , further comprising controlling a separation between adjacent SERS active nanoparticles to be in the range of about 10 to 20 nm.28. The method as claimed in claim 24 , wherein the SERS active nanoparticles are immobilized over the entire length of the fiber.29. The method as ...

METHODS FOR DETECTING PLASTICIZERS

Nanoparticles having one or more attached sensing moieties including uridine 5′-triphosphate (UTP) and deoxythymidine 5′-triphosphate (dTTP), are disclosed herein. These nanoparticles can, for example, be used for detection of plasticizers, such as phthalates, in the sample. Methods, kits and apparatuses using these nanoparticles for detecting plasticizers in a sample are also disclosed herein. 1. A method for detecting a plasticizer in a sample , the method comprising:providing a sample suspected of containing a plasticizer;providing a plurality of nanoparticles having one or more attached sensing moieties, wherein the sensing moiety comprises one or more uridine 5′-triphosphate (UTP) groups, uridine 5′-diphosphate (UDP) groups, uridine monophosphate (UMP) groups, 2′-deoxythymidine 5′-triphosphate (dTTP) groups, 2′-deoxythymidine 5′-diphosphate (dTDP) groups, or deoxythymidine 5′-monophosphate (dTMP) groups;contacting the sample with the plurality of nanoparticles in the presence of a crosslinker to form a mixture;maintaining the mixture under conditions allowing the crosslinker to bind the nanoparticles and any plasticizer present in the sample to form a nanoparticle aggregate; anddetecting the nanoparticle aggregate.2. The method of claim 1 , wherein the nanoparticles are metallic.3. The method of claim 1 , wherein the nanoparticles are gold nanoparticles claim 1 , silver nanoparticles claim 1 , platinum nanoparticles claim 1 , aluminum nanoparticles claim 1 , palladium nanoparticles claim 1 , copper nanoparticles claim 1 , cobalt nanoparticles claim 1 , indium nanoparticles claim 1 , nickel nanoparticles claim 1 , or combinations thereof.4. (canceled)5. The method of claim 1 , wherein the nanoparticles are gold nanoparticles claim 1 , silver nanoparticles claim 1 , quantum dots claim 1 , carbon nanotubes claim 1 , graphene oxides claim 1 , or combinations thereof.6. The method of claim 1 , wherein the nanoparticles have an average diameter of about 12 nm to ...

TOUCH SENSOR AND TOUCH PANEL INCLUDING THE SAME

A touch sensor using a graphene diode and/or a touch panel including the touch sensor. The touch sensor includes a first sensing electrode configured to sense a touch; a first output line configured to transmit an electrical signal; and a first diode device including a first control terminal connected to the first sensing electrode, a first anode terminal connected to a voltage application unit, and a first cathode terminal connected to the first output line. 1. A touch sensor for transforming a touch of a user into an electrical signal , the touch sensor comprising:a first sensing electrode configured to sense the touch;a first output line configured to transmit the electrical signal; anda first diode device including a first control terminal connected to the first sensing electrode, a first anode terminal connected to a voltage application unit, and a first cathode terminal connected to the first output line.2. The touch sensor of claim 1 , wherein the first sensing electrode is configured to increase or decrease a voltage based on the touch claim 1 , the first diode device is configured to turn on or off based on the voltage and the electrical signal is generated by the turned-on or turned-off first diode device.3. The touch sensor of claim 1 , further comprising:a capacitive device connected to the first diode device; anda switching device connected between the capacitive device and the first output line.4. The touch sensor of claim 3 , wherein the capacitive device is configured to store the electrical signal generated by the first diode device claim 3 , andwherein the switching device is configured to transmit the electrical signal stored in the capacitive device to the first output line in response to a scan signal.5. The touch sensor of claim 3 , wherein the switching device includes a transistor device.6. The touch sensor of claim 5 , wherein the transistor device includes a gate terminal configured to receive the scan signal claim 5 , a first source or ...

Metal nanopillars for surface-enhanced Raman Spectroscopy (SERS) substrate and method for preparing same

Disclosed herein describes an SERS sensing substrate comprising upright metal nanostructures made by using oblique angle deposition (OAD) collocating with self-rotation substrate, wherein said upright nanostructures include individual upright nanopillars and metal/dielectric multilayered upright nanopillar stacks. The SERS sensing substrate exhibits higher and enhanced adsorption spectra for unpolarized incident rays in the visible and infrared wavelength regimes. 1. A method for making surface enhanced Raman spectroscopy (SERS) substrate at least having metal nanopillars , comprising:on a rotating substrate, forming metal nanopillars by a oblique angle deposition process, the metal nanopillars having a configuration in which nanopillars are about parallel to a normal line of the substrate.2. The method of claim 1 , the configuration is selected from a group consisting of:(a) metal/substrate,(b) metal/dielectric/substrate,(c) metal/dielectric/metal/substrate,(d) a first metal material/a second metal material/substrate,(e) metal/dielectric/metal/dielectric/substrate,(f) metal/metal/periodical structures of seed layer/substrate, and(g) metal/dielectric/periodical structures of seed layer/substrate.3. The method of claim 1 , wherein the tilting is between 0˜90 degrees claim 1 , the deposition speed is between 0.01 nm/s˜100 nm/s claim 1 , and the substrate rotation speed is between 0.01 rpm˜1000 rpm.4. The method of claim 1 , the metal material is selected from a group consisting of gold (Au) claim 1 , silver (Ag) claim 1 , copper (Cu) claim 1 , or aluminum (Al) claim 1 , lithium (Li) claim 1 , palladium (Pd) claim 1 , platinum (Pt) which is capable of enhancing Raman signals.5. The method of claim 4 , nanopillars are produced on the substrate having periodical claim 4 , non-periodical structures or on the substrate of periodical structures of seed layer/substrate.6. The method of claim 2 , the metal or dielectric nanopillars respectively has the following properties:(a ...

Optoelectrical vapor sensing

A chemical sensor can comprise a nanofiber mass of p-type nanofibers having a HOMO level greater than −5.0 eV. Additionally, the chemical sensor can comprise oxygen in contact with the p-type nanofibers. Further, the chemical sensor can comprise a pair of electrodes in electrical contact across the nanofiber mass, where the p-type nanofibers conduct an electric current that decreases upon contact with an amine compound.

FREQUENCY MULTIPLEXED SUPERCONDUCTING NANOWIRE PHOTON DETECTORS

A photon detection system with improved high-speed performance. An array of photon detectors is provided, providing transient responses that indicate both a time and a location of photon detection. Each photon detector may use a superconducting nanowire, arranged as part of a resonant cell to have a unique resonant frequency. Upon detection of even a single photon, a resonant cell may create a transient response comprising its unique resonant frequency. The transient responses may be combined on a single readout line, allowing identification of the photon detection location based on a detected frequency component read out. The electrical properties within resonant cells, as well as the connections between different resonant cells, may be configured to produce different transient responses. For example, resonant cells may be configured to produce a transient response having multiple pulses, which may separately indicate a time and a location of a photon detection. 1. A photon detection system , comprising:an output line;a plurality of resonant cells coupled to the output line, each resonant cell comprising a nanowire, wherein each of the plurality of resonant cells is configured to provide a different resonant frequency; anda frequency detector coupled to the output line, the frequency detector configured to detect on the output line transient responses of the plurality of resonant cells.2. The photon detection system of claim 1 , wherein:the frequency detector is further configured to indicate a frequency component and a time of initiation of a transient response of any of the plurality of resonant cells.3. The photon detection system of claim 2 , further comprising:a digital code generation circuit coupled to the frequency detector, the digital code generator configured to generate a digital code representing a combination of a value selected based on a detected frequency component and a value indicative of a time of initiation of the transient response.4. The ...

Methods And Systems For Long Distance Tagging, Tracking, And Locating Using Wavelength Upconversion

Methods and systems for plasmonically enhanced bionanoantennas for tagging, tracking, and locating targets of interest at long distances in both day and nighttime conditions. The nanoantennas are used to tag a target of interest and emit a wavelength to impart a unique biometric signature. The nanoantennas are detectable by selectively harvesting and plasmonically enhancing incident light in the visible region, then upconverting that energy through an activated phosphor. 1. A nucleic acid tag comprising:an agglomerated plurality of nanoparticle nucleotide-support platforms each attached to a plurality of nucleic acid molecules, each of said nucleic acid molecules comprising identifying information, wherein a spacer is located between said nanoparticle nucleotide-support platform and said identifying information;an upconverting fluorescent material; andan encapsulant surrounding said agglomerated plurality of nanoparticle nucleotide-support platforms and said plurality of nucleic acid molecules;wherein when the nucleic acid tag is exposed to electromagnetic radiation of a first wavelength, the upconverting fluorescent material emits electromagnetic radiation of a second wavelength, said second wavelength being shorter than said first wavelength.2. The nucleic acid tag of claim 1 , further comprising:a plasmonic enhancer.3. The nucleic acid tag of claim 1 , wherein the encapsulant is adapted to prevent degradation of the plurality of nucleic acid molecules.4. The nucleic acid tag of claim 1 , wherein each of the plurality of nucleic acid molecules is composed of nucleotides selected from the group consisting of ribonucleotides claim 1 , deoxyribonucleotides claim 1 , and nucleotide analogues.5. The nucleic acid tag of claim 1 , wherein each of the plurality of nucleic acid molecules is an oligonucleotide.6. The nucleic acid tag of claim 1 , wherein each of the plurality of nucleic acid molecules is genomic deoxyribonucleic acid ranging from two nucleotides to the ...

METALLIC-NANOFINGER DEVICE FOR CHEMICAL SENSING

A metallic-nanofinger device for chemical sensing. The device includes a substrate, and a plurality of nanofingers. A nanofinger includes a flexible column, and a metallic cap coupled to an apex of the flexible column. At least the nanofinger and a second nanofinger are to self-arrange into a close-packed configuration with at least one analyte molecule disposed between at least the metallic cap and a second metallic cap of respective nanofinger and second nanofinger. A morphology of the metallic cap is to generate a shifted plasmonic-resonance peak associated with amplified luminescence from the analyte molecule. A coating encapsulating the metallic cap to respond upon exposure to a liquid, and a chemical-sensing chip including the metallic-nanofinger device are also provided. 1. A metallic-nanofinger device for chemical sensing , said device comprising:a substrate; and a flexible column; and', 'a metallic cap coupled to an apex of said flexible column;, 'a plurality of nanofingers coupled with said substrate, a nanofinger of said plurality comprisingwherein at least said nanofinger and a second nanofinger of said plurality of nanofingers are to self-arrange into a close-packed configuration with at least one analyte molecule disposed between at least said metallic cap and a second metallic cap of respective nanofinger and second nanofinger; andwherein a morphology of said metallic cap is to generate a shifted plasmonic-resonance peak associated with amplified luminescence from said analyte molecule.2. The metallic-nanofinger device of claim 1 , wherein said plasmonic-resonance peak associated with luminescence from said analyte molecule is shifted towards longer wavelengths of said shifted plasmonic-resonance peak.3. The metallic-nanofinger device of claim 1 , wherein said plasmonic-resonance peak associated with luminescence from said analyte molecule is shifted towards shorter wavelengths of said shifted plasmonic-resonance peak.4. The metallic-nanofinger device ...

ELECTRICALLY DRIVEN DEVICES FOR SURFACE ENHANCED RAMAN SPECTROSCOPY

An electrically driven device for surface enhanced Raman spectroscopy includes a substrate, a Raman signal-amplifying structure positioned on the substrate, and an analyte receptor attached to a structure chosen from i) the Raman signal-amplifying structure, or ii) the substrate near the Raman signal-amplifying structure, or iii) combinations of i and ii. The analyte receptor has a selective binding affinity for an analyte. Conductive elements are positioned relative to one another and to the analyte receptor such that the conductive elements together produce an electric field in the vicinity of the analyte receptor when a voltage bias is applied between the conductive elements. 1. An electrically driven device for surface enhanced Raman spectroscopy , the device comprising:a substrate;a Raman signal-amplifying structure positioned on the substrate;an analyte receptor attached to a structure chosen from i) the Raman signal-amplifying structure, or ii) the substrate near the Raman signal-amplifying structure, or iii) combinations of i and ii, the analyte receptor having a selective binding affinity for an analyte; andconductive elements positioned relative to one another and to the analyte receptor such that the conductive elements together produce an electric field in the vicinity of the analyte receptor when a voltage bias is applied between the conductive elements.2. The electrically driven device as defined in wherein the analyte receptor is to reversibly bind the analyte.3. The electrically driven device as defined in wherein the selective binding affinity is weaker than a force to release from the analyte receptor the analyte bound thereto.4. The electrically driven device as defined in wherein the force is an electrophoretic force or a dielectrophoretic force.5. The electrically driven device as defined in wherein the analyte receptor is selected from the group consisting of positively charged 4-mercaptopyridinium claim 1 , cationic mercaptoalkyl amines claim ...

Sputtering sources for high-pressure sputtering with large targets and sputtering method

A sputtering head comprises a receiving area for a sputtering target (target receptacle). The sputtering head comprises one or more magnetic field sources so as to generate a stray magnetic field. The magnetic north and the magnetic south of at least one magnetic field source, between which the stray field forms, are located 10 mm or less, preferably 5 mm or less, and particularly preferably approximately 1 mm apart. It was found that, notably when sputtering at a high sputtering gas pressure of 0.5 mbar or more, the degree of ionization of the sputtering plasma, and consequently also the ablation rate of the sputtering target, can be locally adjusted by such a locally effective magnetic field. This allows the thicknesses of the layers that are obtained to be more homogeneous over the surface of the substrate. Advantageously, the sputtering head additionally comprises a solid state insulator, which surrounds the base body comprising the target receptacle and the sputtering target (all connected to potential) and electrically insulates the same from the shield that spatially limits the material ablation to the sputtering target (connected to ground).

Multifunctional nanoplatforms for fluorescence imaging and photodynamic therapy developed by post-loading photosensitizer and fluorophore to polyacrylamide nanoparticles

A composition comprising PAA nanoparticles containing a post loaded tetrapyrollic photosensitizer and a postloaded imaging agent and methods for making and using same.

Functionalized Carbon Nanotube Sheets for Electrochemical Biosensors and Methods

Electrodes and methods for making electrodes including modified carbon nanotube sheets are provided. The carbon nanotube sheets can be modified with metal particles or at least one mediator titrant. The electrodes can be disposed on a glassy carbon electrode to modify the glassy carbon electrode. Methods are provided that include forming a suspension of carbon nanotubes and metal particles or at least one mediator titrant, and filtering the suspension to form a modified carbon nanotube sheet. 1. A method for making an electrode comprising:forming a suspension comprising carbon nanotubes at least one mediator titrant;filtering the suspension to obtain a modified carbon nanotube sheet; andarranging the modified carbon nanotube sheet on a glassy carbon electrode.2. The method of claim 1 , wherein the at least one mediator titrant comprises methylene blue claim 1 , thionine claim 1 , or PMS.3. The method of claim 1 , wherein the carbon nanotube sheets comprise SWNTs claim 1 , MWNTs claim 1 , carbon nanofibers claim 1 , or a combination thereof.4. The method of claim 1 , wherein the carbon nanotubes are acid-functionalized claim 1 , amino-functionalized claim 1 , acid-modified claim 1 , or a combination thereof.5. The method of claim 1 , wherein the carbon nanotubes comprise carboxyl groups.6. An electrode comprising a carbon nanotube sheet modified with at least one mediator titrant.7. The electrode of claim 6 , further comprising a glassy carbon electrode claim 6 , wherein the carbon nanotube sheet is disposed on the glassy carbon electrode.8. The electrode of claim 6 , wherein the at least one mediator titrant comprises methylene blue claim 6 , thionine claim 6 , or PMS.9. An electrode comprising a carbon nanotube sheet modified with metal particles.10. The electrode of claim 9 , wherein the metal particles are non-covalently bound to the carbon nanotube sheet.11. The electrode of claim 9 , wherein the metal particles comprise nanoparticles.12. The electrode of claim ...

SILICA NANOPARTICLES WITH AGGREGATION INDUCED EMISSION CHARACTERISTICS AS FLUORESCENT BIOPROBE FOR INTRACELLULAR IMAGING AND PROTEIN CARRIER

Provided herein are magnetic silica fluorescent nanoparticles and fluorescent silica nanoparticles comprising an aggregation induced emission luminogen and magnetite nanoparticles and use of the same as a fluorescent bioprobe for intracellular imaging and a protein carrier. Also provided are processes for preparing and fabricating the same. 3. The fluorescent bioprobe of claim 1 , wherein the magnetic fluorescent silica nanoparticles and the fluorescent silica nanoparticles are also protein carriers.4. The fluorescent bioprobe of claim 1 , wherein the magnetic fluorescent silica nanoparticles and fluorescent silica nanoparticles exhibit aggregation-induced emission.5. The fluorescent bioprobe of claim 1 , wherein the magnetic fluorescent silica nanoparticles exhibit superparamagnetism.6. The fluorescent bioprobe of claim 1 , wherein the magnetic fluorescent silica nanoparticles exhibit high magnetization with negligible remanence and coercivity.7. The fluorescent bioprobe of claim 1 , wherein the magnetic fluorescent silica nanoparticles and the fluorescent silica nanoparticles emit light; and wherein the light emission increases with increased luminogen loading.8. The fluorescent bioprobe of claim 1 , wherein the aggregation induced emission luminogen is in solid form.9. The fluorescent bioprobe of claim 1 , wherein the magnetic fluorescent silica nanoparticles comprise magnetic cores covered by a silica shell.10. The fluorescent bioprobe of claim 1 , wherein the fluorescent silica nanoparticles comprise fluorescent cores covered by a silica shell.11. The fluorescent bioprobe of claim 1 , wherein the magnetic fluorescent silica nanoparticles and the fluorescent silica nanoparticles are spherical with substantially uniform sizes and narrow particle distributions.12. The fluorescent bioprobe of claim 1 , wherein the magnetic fluorescent silica nanoparticles and the fluorescent silica nanoparticles possess high surface charges and good colloidal stabilities.13. The ...

INTEGRATED DEVICE FOR REAL TIME QUANTITATIVE PCR

A method for real-time quantitative detection of single-type, target nucleic acid sequences amplified using a PCR in a microwell, comprising introducing in the microwell a sample comprising target nucleic acid sequences, magnetic primers, and labelling probes; performing an amplification cycle to form labelled amplicons; attracting the magnetic primers to a surface through a magnetic field to form a layer including labelled amplification products and free magnetic primers; and detecting the labelled amplification products in the layer with a surface-specific reading method. 1. A method for real-time quantitative detection of single-type , target nucleic acid sequences amplified using a PCR in a microwell , comprising:introducing in the microwell a sample comprising target nucleic acid sequences, magnetic primers, and labelling probes;performing one or more amplification cycles to form labelled amplicons;attracting the magnetic primers to a surface through a magnetic field to form a multilayer including labelled amplification products and free magnetic primers; anddetecting the labelled amplification products in the multilayer with a surface-specific reading method during one or more of said amplification cycles.2. The method according to claim 1 , wherein the step of detecting the labelled amplification products comprises using a surface-specific reading device having a vertical resolution claim 1 , and the multilayer has a thickness matched to the vertical resolution of the surface-specific reading device.3. The method according to claim 1 , wherein the step of detecting the labelled amplification products comprises using a surface-specific reading device having a focal plane and the step of detecting the labelled amplification products comprises setting the focal plane at a central region of the multilayer.4. The method according to claim 1 , wherein the step of introducing magnetic primers comprises using primers attached on paramagnetic beads having a diameter ...

Atomic force microscope probe

An atomic force microscope probe includes a carbon nanotube micro-tip structure. The carbon nanotube micro-tip structure includes an insulating substrate and a patterned carbon nanotube film structure. The insulating substrate includes a surface. The surface includes an edge. The patterned carbon nanotube film structure is partially arranged on the surface of the insulating substrate. The patterned carbon nanotube film structure includes two strip-shaped arms joined together to form a tip portion protruding and suspending from the edge of the surface of the insulating substrate. The two strip-shaped arms include a number of carbon nanotubes parallel to the surface of the insulating substrate.

Imaging Probe Including Nanoparticle

An imaging probe can include a photoluminescent carbon nanostructure configured to emit a wavelength of light detectable through living tissue, and a targeting moiety including a first binding partner configured to interact with a second binding partner. 1. An imaging probe , comprising:a photoluminescent nanostructure configured to emit a wavelength of light detectable through living tissue; anda targeting moiety including a first binding partner configured to interact with a second binding partner.2. The imaging probe of claim 1 , wherein the second binding partner includes a tissue-type specific or cell-type specific molecule.3. The imaging probe of claim 1 , wherein the second binding partner includes a protein.4. The imaging probe of claim 1 , wherein the first binding partner includes a protein.5. The imaging probe of claim 1 , wherein the first binding partner includes at least a portion of an antibody.6. The imaging probe of claim 1 , wherein the first binding partner includes at least a portion of a ligand and the second binding partner includes a receptor.7. The imaging probe of claim 1 , wherein the targeting moiety includes at least one viral protein.8. The imaging probe of claim 7 , wherein the at least one viral is a M13 bacteriophage protein.9. The imaging probe of claim 7 , wherein the at least one viral protein is a capsid protein.10. The imaging probe of claim 1 , wherein the first binding partner and the at least one viral protein comprise a chimeric protein.11. The imaging probe of claim 1 , wherein the photoluminescent nanostructure is a carbon nanostructure.12. The imaging probe of claim 1 , wherein the first binding partner configured to interact with the second binding partner in vivo.13. The imaging probe of claim 1 , wherein the first binding partner configured to interact with the second binding partner ex vivo.14Escherichia coli.. The imaging probe of claim 1 , wherein the targeting moiety includes15Escherichia coli. The imaging probe of ...

DIRECT DETECTION OF UNAMPLIFIED HEPATITIS C VIRUS RNA USING UNMODIFIED GOLD NANOPARTICLES

A gold nanoparticle-based colorimetric assay kit for hepatitis C virus RNA that detects unamplified HCV RNA in clinical specimens using unmodified AuNPs and oligotargeter polynucleotides that bind to HCV RNA. A method for detecting hepatitis C virus comprising contacting a sample suspected of containing hepatitis C virus with a polynucleotide that binds to hepatitis C virus RNA and with gold nanoparticles, detecting the aggregation of nanoparticles, and detecting hepatitis C virus in the sample when the nanoparticles aggregate (solution color becomes blue) in comparison with a control or a negative sample not containing the virus when nanoparticles do not aggregate (solution color remains red). 1. A method for detecting hepatitis C virus comprisingcontacting a sample suspected of containing hepatitis C virus with an oligotargeter that binds to hepatitis C virus RNA and with gold nanoparticles,detecting the aggregation of nanoparticles, anddetecting hepatitis C virus in the sample when the nanoparticles aggregate (solution becomes blue) in comparison with a control or a negative sample not containing the virus where the nanoparticles do not aggregate (solution remains red).2. The method of claim 1 , wherein the sample is blood or plasma.3. The method of claim 1 , wherein the sample is serum claim 1 , optionally containing EDTA.4. The method of claim 1 , wherein the sample is saliva.5. The method of claim 1 , wherein the sample is urine.6. The method of claim 1 , wherein the gold nanoparticles are spherical and have an average diameter of 12 to 20 nm.7. The method of claim 1 , wherein the gold nanoparticles are spherical and have an average diameter of 15-18 nm.8. The method of claim 1 , wherein the oligotargeter that binds to hepatitis C RNA comprises a portion of a 5′ untranslated region of hepatitis C genomic RNA.9. The method of claim 1 , wherein the oligotargeter that binds to hepatitis C RNA comprises a portion of hepatitis C genomic RNA other than the 5′ ...

FILM FORMING METHOD AND FILM FORMING APPARATUS

A film forming method which generates metal ions from a metal target with a plasma in a processing chamber and attracts the metal ions with a bias to deposit a metal thin film on a target object wherein trenches are formed. The method includes: generating metal ions from a target and attracting the metal ions into a target object with a bias to form a base film in a trench; ionizing a rare gas with the bias in a state where no metal ion is generated and attracting the generated ions into the target object to etch the base film; and plasma sputtering the target to generate metal ions and attracting the metal ions into the object with a high frequency power for bias to deposit a main film as a metal film, while reflowing the main film by heating. 1. A film forming method for depositing a metal thin film in a recess formed in a target object , which is mounted on a mounting table in a vacuum processing chamber , by attracting metal ions into the target object by supplying a high frequency power for bias to the mounting table to apply a bias to the target object , the metal ions being generated by ionizing a metal target by a plasma in the processing chamber , the method comprising:a base film forming step of forming a base film containing the metal in the recess by attracting the metal ions into the target object with the bias;an etching step of etching the base film by attracting ions of a rare gas into the target object, the ions of the rare gas being generated by ionizing the rare gas by generating a plasma in a state where the metal ions are not generated while applying the bias to the target object; anda film formation reflow step of depositing a main film as a metal film by attracting ions of the metal into the target object with the bias applied to the target object while reflowing the main film by heating.2. The film forming method of claim 1 , wherein the high frequency power for bias in the etching step is larger than the high frequency power for bias in the ...

ELECTRON MULTIPLIER DEVICE HAVING A NANODIAMOND LAYER

An electron multiplier for a system for detecting electromagnetic radiation or an ion flow is disclosed. The multiplier includes at least one active structure intended to receive a flow of incident electrons, and to emit in response a flow of electrons called secondary electrons. The active structure includes a substrate on which is positioned a thin nanodiamond layer formed from diamond particles the average size of which is less than or equal to about 100 nm. 1. A reflection-mode electron multiplier device to detect electromagnetic radiation or ion flows , the device comprising:at least one active structure configured to receive a flow of incident electrons and to emit in response a flow of secondary electrons, where the active structure comprises a substrate and a thin nanodiamond layer on the substrate, the nanodiamond layer being formed of diamond particles, the average size of the particles is less than about 100 nm,wherein the active structure is a microchannel wafer in which each of a plurality of microchannels traverses the substrate from an input aperture for the flow of incident electrons to an output aperture for the flow of the secondary electrons, where the nanodiamond layer extends over the inner surface of each of the microchannels from the corresponding input aperture.2. An electron multiplier device according to claim 1 , wherein the nanodiamond layer extends over a length of a microchannel of between one and thirty times the average diameter of the microchannels.3. An electron multiplier device according to claim 1 , wherein the nanodiamond layer extends over an inner surface of each of the microchannels for as far as a distance claim 1 , relative to the corresponding output aperture claim 1 , of between one and ten times the average diameter of the microchannels.4. An electron multiplier device according to claim 1 , wherein the nanodiamond layer extends over the entire length of an inner surface of each of the microchannels for as far as the ...

METHODS FOR UNIFORM METAL IMPREGNATION INTO A NANOPOROUS MATERIAL

The methods, systems and apparatus disclosed herein concern metal impregnated porous substrates Certain embodiments of the invention concern methods for producing metal-coated porous silicon substrates that exhibit greatly improved uniformity and depth of penetration of metal deposition. The increased uniformity and depth allow improved and more reproducible Raman detection of analytes. In exemplary embodiments of the invention, the methods may comprise oxidation of porous silicon immersion in a metal salt solution, drying and thermal decomposition of the metal salt to form a metal deposit In other exemplary embodiments of the invention, the methods may comprise microfluidic impregnation of porous silicon substrates with one or more metal salt solutions Other embodiments of the invention concern apparatus and/or systems for Raman detection of analytes, comprising metal-coated porous silicon substrates prepared by the disclosed methods. 121.-. (canceled)22. A microfluidic system comprising a porous silicon substrate wherein the porous silicon substrate has a metal coating , a microfluidic pathway wherein the micro fluidic pathway is operably coupled to the porous silicon substrate wherein the microfluidic pathway is capable of allowing a fluid to be delivered to the porous silicon substrate , and a detection system capable of detecting a change in a region of the porous silicon substrate comprising the metal coating.23. The microfluidic system of wherein the porous silicon substrate comprises porous polysilicon or porous nanocrystalline silicon.24. The microfluidic system of wherein the metal coating comprises gold.25. The system of wherein the metal coating comprises silver claim 22 , platinum claim 22 , or aluminum.26. The microfluidic system of wherein the metal coating is formed by contacting the porous silicon substrate with a metal salt solution and heating the porous silicon substrate to form the metal coating on the porous silicon substrate.27. The ...

Systems and Methods for Analyte Detection

This disclosure provides a system component and method for analysis of airborne analytes by absorbing the analytes into a liquid and interrogating the liquid with an analytical instrument. In some examples, a cartridge with a microfluidic chip contains a vessel of a colloidal solution of nanostructured particles in a liquid. The vessel is broken, releasing the solution into microfluidic containers on the chip. Air having analytes is passed over the chip leading to absorption of airborne analytes into the solution. The analytes bind with the nanostructures and are detected optically. Techniques are disclosed for filling the vessel in a way that maintains the efficacy of the solution until it is needed for measurement. 1. A cartridge for use in a microfluidic system for the detection and/or measurement of ambient gases and/or analytes in a gas or liquid sample , the cartridge comprising:a microfluidic chip including at least one microfluidic container with at least one free surface;an optical window for optical interrogation of the microfluidic container;a colloid vessel chamber disposed in proximity to said microfluidic container, wherein said colloid vessel chamber includes a colloid vessel comprising colloidal solution, the colloid solution comprising a liquid and nanostructured particles; andan fluid flow manifold disposed in a configuration suitable to direct a flow of said gas or liquid across the microfluidic chip.2. (canceled)3. The cartridge of claim 1 , further comprising an access port disposed to allow a vessel breaking tool to contact the colloid vessel.4. The cartridge of claim 1 , wherein the colloid vessel is an ampoule.5. The cartridge of claim 4 , wherein the ampoule comprises a spherical region.6. The cartridge of claim 5 , wherein the ampoule has a diameter from about 1 millimeter (mm) to 15 mm and a tube region of length from about 0.5 cm to 5 cm.7. The cartridge of claim 1 , wherein the vessel comprises a foil packet including a metal packet with ...

DEVICE AND METHOD UTILIZING A METALLIC NANOPARTICLE ASSEMBLY STRUCTURE FOR DETECTING A TARGET SUBSTANCE

Disclosed is a device and method allowing a trace amount of a target substance to be detected. A metallic nanoparticle assembly structure is formed of metallic nanoparticles assembled together and modified with a host molecule allowing the target substance to specifically adhere thereto. A metallic nanorod is modified with a host molecule allowing the target substance to specifically adhere thereto. The metallic nanorod is conjugated to the metallic nanoparticle assembly structure by the target substance. An extinction spectrum of localized surface plasmon resonance or a surface enhanced Raman scattering (SERS) spectrum induced in the metallic nanoparticle assembly structure and the metallic nanostructure is measured with a spectroscope. The target substance is detected based on that spectrum. 121-. (canceled)22. A detection device for detecting a target substance that may be contained in a specimen , comprising:a metallic nanoparticle assembly structure including a bead and a plurality of metallic nanoparticles fixed to a surface of said bead via an interacting site and modified with a first host molecule allowing said target substance to specifically adhere thereto; anda metallic nanostructure modified with a second host molecule allowing said target substance to specifically adhere thereto, said metallic nanoparticle assembly structure having said plurality of metallic nanoparticles mutually spaced by a distance equal to or smaller than a diameter of said metallic nanoparticle.23. The detection device for detecting a target substance according to claim 22 , further comprising a substrate for fixing said metallic nanoparticle assembly structure thereto.24. The detection device for detecting a target substance according to claim 22 , further comprising:a first light source for irradiating said specimen with light with said metallic nanoparticle assembly structure and said metallic nanostructure introduced in said specimen;a spectroscope for measuring a spectrum of ...

Substrate processing system with mechanically floating target assembly

Substrate processing systems are provided herein. In some embodiments, a substrate processing system may include a target assembly having a target comprising a source material to be deposited on a substrate; a grounding assembly disposed about the target assembly and having a first surface that is generally parallel to and opposite a backside of the target assembly; a support member coupled to the grounding assembly to support the target assembly within the grounding assembly; one or more insulators disposed between the backside of the target assembly and the first surface of the grounding assembly; and one or more biasing elements disposed between the first surface of the grounding assembly and the backside of the target assembly to bias the target assembly toward the support member.

PARTICLE-BEAM COLUMN CORRECTED FOR BOTH CHROMATIC AND SPHERICAL ABERRATION

An objective lens for use in probe-forming particle-optical columns such as focused ion beam equipment, scanning electron microscopes, and helium microscopes is described. It comprises two interleaved (quadrupole/octopole) lenses and two or three ancillary octopole lenses, and is capable of simultaneous compensation of spherical (Cs) and chromatic (Cc) aberrations of the objective lens alone or of the complete particle-optical column. Additional apparatus comprising a gridded aperture and position-sensitive detector is specified, together with a method to measure and minimize all of the five independent third-order aberration coefficients of the objective lens. 2. An improved particle-optical column comprising interleaved lenses as in wherein the improvement further comprisesa third ancillary normal octopole lens, wherever located along the axis of the column,{'sup': 'rd', 'and wherein the further improvement functions for the purpose of compensation of intrinsic and parasitic 3-order aperture aberrations of the entire column.'}3. An improved particle-optical column as in claim 1 ,in which the interleaved lenses are operated at the critical ratio of electric to magnetic fields, such that they add no chromatic aberration to the positive chromatic aberration of all other particle-optical components, and the dependence of spot diameter upon energy is reduced in comparison to a column employing only electrostatic lenses to form the fine beam,4. An improved particle-optical column as in claim 2 ,in which the interleaved lenses are operated at the critical ratio of electric to magnetic fields, such that the negative chromatic aberration of the interleaved lenses cancels the positive chromatic aberration of all other particle-optical components, and the spot diameter is substantially independent of small changes in the particle energy,5. An improved particle-optical column as in whereinat least one of the normal octopole lenses is an interleaved quadrupole lens improved by ...