03-02-2022 дата публикации
Номер: US20220033388A1
Принадлежит:
Provided herein are compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat diseases or disorders associated with HDAC1 and/or HDAC2 activity. 2. The compound of claim 1 , wherein:{'sup': '1', 'sub': '2', 'Ris selected from the group consisting of phenyl, phenyl-OH, phenyl-OSONHMe, thienyl, and furanyl;'}{'sup': '2', 'sub': 2', '1', '3, 'Ris selected from the group consisting of —H, methyl, —CH-cyclopropyl, and C-Calkyl-5-6 membered heterocycloalkyl; and'}{'sup': 3', '4, 'Rand Rare independently, at each occurrence, selected from the group consisting of —H, halo, and methyl.'}4. The compound of claim 3 , wherein:{'sup': '1', 'Ris phenyl or thienyl;'}{'sup': '2', 'sub': '2', 'Ris selected from the group consisting of absent, —H, methyl, and C-alkyl-5-6 membered heterocycloalkyl;'}{'sup': '3', 'sub': '2', 'Ris selected from the group consisting of absent, —H, and —C-alkyl-5-6 membered heterocycloalkyl; and'}{'sup': '4', 'Ris selected from the group consisting of —H, cyclopropyl, and methyl.'}7. The compound of claim 6 , wherein{'sup': '1', 'sub': '2', 'Ris —NHor —OH;'}{'sup': 2', '5, 'Ris halo or heteroaryl, wherein heteroaryl is optionally substituted by one or more R;'}{'sup': 3', '6', '6', '6', '6', '6', '5, 'sub': 1', '3', '2', '1', '3', '2', '1', '3, 'Ris independently, at each occurrence, selected from the group consisting of cycloalkyl, heterocycloalkyl, —N(R)—C-Calkyl-N(R), —O—C-Calkyl-N(R), and —N(R)—C-Calkyl-OR, wherein cycloalkyl and heterocycloalkyl are optionally substituted by one or more R;'}{'sup': '4', 'sub': 1', '6, 'Ris independently, at each occurrence, —H or C-Calkyl;'}{'sup': '5', 'sub': 1', '6, 'Ris independently, at each occurrence, —H or C-Calkyl;'}{'sup': '6', 'sub': 1', '6, 'Ris independently, at each occurrence, —H or C-Calkyl;'}and n is 1, 2, or 3.9. The compound of any one of - claim 6 , wherein Ris independently claim 6 , at each occurrence claim 6 , selected from the group ...
Подробнее
