New peptide amides and process for their manufacture
Номер патента: AU543519B2
Опубликовано: 26-04-1985
Автор(ы): Hans Georg Alpermann, Martin Bickel, Rolf Geiger, Volker Teetz
Принадлежит: Hoechst AG
Опубликовано: 26-04-1985
Автор(ы): Hans Georg Alpermann, Martin Bickel, Rolf Geiger, Volker Teetz
Принадлежит: Hoechst AG
Реферат: New peptide amides of the formula I H-Tyr-D-Lys(For)-Gly-X (I) wherein For is formyl, X is alkylamino, dehydro-Phe or Phe-alkylamido having up to 6 carbon atoms in the alkyl moiety, which moiety may be substituted by hydroxy and/or phenyl, Phe-cycloalkylamide or Phe-cycloalkylene amide having up to 8 carbon atoms in the cycloalkyl or cyclalkylene moiety, 1 to 2 CH2 groups being optionally replaced by -NH-, -O-, -S- or -CO-, Phe-alkylene-cycloalkylamide having from 5 to 6 ring carbon atoms, which amide may be substituted by carbonamido,N-alkylcarbonamido or alkyl and 1 carbon atom whereof may be replaced by nitrogen, Phe-endo- or exo-norbornylamide or Phe-thiazolamide or Phe-thiazolidine-carboxylic acid amide, which may be substituted by 1 to 4 methyl groups each, and process for their manufacture are disclosed. These peptide amides are distinguished by an analgetic activity and suppress the motility of the ileum of the guinea pig.
Peptide amides and process for their manufacture
Номер патента: CA1158237A. Автор: Martin Bickel,Rolf Geiger,Volker Teetz,Hans G. Alpermann. Владелец: Hoechst AG. Дата публикации: 1983-12-06.