Identification of drugs targeting non-genetic drug tolerance programs in cancer
Номер патента: EP3559276A1
Опубликовано: 30-10-2019
Автор(ы): Stefanie FLÜCKIGER-MANGUAL, Wilhelm Krek
Принадлежит: Eidgenoessische Technische Hochschule Zurich ETHZ
Опубликовано: 30-10-2019
Автор(ы): Stefanie FLÜCKIGER-MANGUAL, Wilhelm Krek
Принадлежит: Eidgenoessische Technische Hochschule Zurich ETHZ
Реферат: A cell-based screening method is provided. The screening method aims to identify drugs for the treatment of cancers characterized by cells with an over-activated signalling pathway in a combination medicament with an inhibitor of the respective over-activated signalling pathway. In particular, the expression level of SOX2 is determined to identify compounds that prevent the development of resistance to inhibitors of the MAPK and EGFR pathway.
Identification of drugs targeting non-genetic drug tolerance programs in cancer
Номер патента: AU2017384617A1. Автор: Stefanie FLÜCKIGER-MANGUAL,Wilhelm Krek. Владелец: Eidgenoessische Technische Hochschule Zurich ETHZ. Дата публикации: 2019-06-13.