Room temperature stable, lyophilized natriuretic peptide formulations
Номер патента: EP2234603A1
Опубликовано: 06-10-2010
Автор(ы): Supriya Gupta, Yanli Mi
Принадлежит: EKR Therapeutics Inc
Опубликовано: 06-10-2010
Автор(ы): Supriya Gupta, Yanli Mi
Принадлежит: EKR Therapeutics Inc
Реферат: Lyophilized pharmaceutical compositions comprise a natriuretic peptide, a buffer and a bulking agent that are stable at room temperature. Preferably, for a fill volume of 1 mL (pre-lyophilization), the total cake mass, post-lyophilization, is 30-175 mg. Preferably, the natriuretic peptide is ularitide or a pharmaceutically acceptable salt thereof. Various embodiments of the compositions may further comprise at least one of an acid and a base. In some embodiments, the pH of the compositions is between 4.0 and 6.0. In addition, various embodiments of the compositions may further comprise a stabilizing agent. In some embodiments, the compositions are isotonic. Preferably, the compositions are used for the treatment of cardiac conditions. The invention also relates to methods for preparing such compositions.
Application of variants of natriuretic peptide of c-type for treatment of skeletal dysplasia
Номер патента: RU2728567C2. Автор: Шерри БУЛЛЕНС,Стюарт БАНТИНГ,Тяньвэй ЧОУ,Аугустус О. ОКХАМАФЕ,Кристофер П. ПРАЙС,Дэниел Дж. ВЕНДТ,Кларенс ЯП. Владелец: Байомарин Фармасьютикал Инк.. Дата публикации: 2020-07-30.