Vaccine comprising a mutant rabies virus N protein which has an amino acid other than serine at position 389 and possibly one or more other mutations within the N protein
Номер патента: NZ531025A
Опубликовано: 26-08-2005
Автор(ы): Zhen Fang Fu
Принадлежит: Univ Georgia Res Found
Опубликовано: 26-08-2005
Автор(ы): Zhen Fang Fu
Принадлежит: Univ Georgia Res Found
Реферат: A mutant virus is provided that contains a mutation at a phosphorylation site in one or more of the proteins of the virus, which mutation causes the virus to be attenuated, and therefore, a vaccine composition can be produced with that mutant virus. Also described are vaccine compositions, which contain the mutant virus, as well as methods of inducing an immune response, and of protecting mammals from infection by rabies virus. Also included are methods of producing the mutant virus and mutant viral proteins, including producing the mutant virus in an isolated host cell that produces or even overproduces a wild-type counterpart of the mutant viral protein, which complements the other viral proteins such that production of the mutant viral particle is optimised. Also included are those host cells in which viral production is optimised, as well as vaccine compositions including the viral proteins, either alone or in combination with the intact virus, and methods of inducing an immune response or protecting a mammal from infection, using the same. Also included are vectors suitable for delivering a gene to a cell of a human or animal, as well methods of delivery thereof.
Amino acids, nucleotides and vectors expressing the same and uses thereof in preventing sarbecovirus infection
Номер патента: US20240261389A1. Автор: FENG ZHU,Linfa Wang,Wan Ni CHIA,Chee Wah TAN. Владелец: NATIONAL UNIVERSITY OF SINGAPORE. Дата публикации: 2024-08-08.