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Novel compounds having selective inhibiting effect at gsk3

Номер патента: AU2003287136A8
Опубликовано: 09-07-2004
Автор(ы): Stefan Berg, Sven Hellberg
Принадлежит: AstraZeneca AB

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Novel compounds having selective inhibiting effect at gsk3

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Novel compounds having selective inhibiting efect at gsk3

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Novel compounds having selective inhibiting effect at GSK3

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Fused heterocycle compound having sulfonamide group or salt thereof, agricultural/horticultural pesticide and external or internal parasite controlling agent for animals containing said compound or salt thereof, and method of use therefor

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Novel compound and pharmaceutical composition comprising same

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N-(pyrrol-1-yl)pyridinamine compounds having enhancing activity

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Novel compounds for producing substituted sulfoxides, process for producing the same and use thereof

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Novel compound and organic light emitting device comprising the same

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Novel compounds to treat cytokine related disorders

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Substituted indole compounds having NOS inhibitory activity

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Compound having nitrogen-containing six-membered aromatic ring structure, and material for organic light-emitting-diode, electron transport material, and organic light-emitting-diode using the same

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Compound having nitrogen-containing six-membered aromatic ring structure, and material for organic light-emitting-diode, electron tranport material, and organic light-emitting-diode using the same

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Compounds having bipyridyl group and carbazole ring, and organic electroluminescent element

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Organic compound having improved luminescent properties, organic light emitting diode and organic light emitting device including the organic compound

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Dihydroxybenzamide compound having HSP90 inhibitory activity or pharmaceutically acceptable salt thereof, and medical use thereof

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6-substituted-2(1H)-quinolinones and related compounds having use as cardiotonic, antihypertensive, and antithrombotic agents

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Novel compounds and their uses

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Novel compound having inhibitory effect on lipase

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Novel compound having inhibitory effect on lipase

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Diphenylpyrrolo[1,2-a]pyrazine-3-carboxamides-compounds having neuropsychotropic activity, methods for preparing them

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Novel compounds as histone deacetylase 6 inhibitor, and pharmaceutical composition comprising the same

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Novel compound having antimalarial activity

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Novel compound having inhibitory activity against pendrin, and pharmaceutical uses thereof

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Novel compound having parp inhibitory activity

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Novel compounds having indazole frameworks, methods for preparing the same and pharmaceutical composition comprising the same

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Novel compounds having inhibitory activity against glucosylceramide synthase or pharmaceutically acceptable salt thereof, processes for preparing the same, and pharmaceutical compositions comprising the same

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Compound Having Activity Of Blocking NMDA Receptor Channel, and Pharmaceutical Agent Using The Same

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Novel compound of 2,3,5-substituted thiophene as a protein kinase inhibitor

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Mitochondrial permeability transition pore (mptp)-opening inhibitor, novel compound exhibiting mptp-opening inhibitory activity, and use therefor

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MITOCHONDRIAL PERMEABILITY TRANSITION PORE (mPTP)-OPENING INHIBITOR, NOVEL COMPOUND EXHIBITING mPTP-OPENING INHIBITORY ACTIVITY, AND USE THEREFOR

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Novel compounds as cathepsin inhibitors, pharmaceutical composition based on thereof, their using and method for their preparing

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Novel compounds with spirochiral carbon base, methods of their obtaining and pharmaceutical compositions which contain such compounds

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Novel compounds that are erk inhibitors

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Method of synthesis of novel compounds obtained from 3-hydroxycyclopentylacetic acid

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Novel compounds, representing reverse-turn mimetics, and their application

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Compound having gpr119 agonistic activity, method for preparing the same, and pharmaceutical composition including the same as effective component

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Compound having skin-whitening, anti-oxidizing and PPAR activities and medical use thereof

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Use of tricyclic derivatives of 1,4-dihydro-1,4-dioxo-1h-naphthalene and its novel compounds, pharmaceutical composition based on thereof and derivatives of substituted naphthalenes as intermediate compounds

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Novel compounds for treatment of cardiac arrhythmia, synthesis, and methods of use

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Novel compounds having a tetracyclic iridoid skeleton and an anti-trypanosomal, anti-leishmanial and anti-plasmodial agents comprising the same as an active ingredient

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Novel compounds

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Novel compounds and use thereof for targeted delivery

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Novel compound of stemphones and production thereof

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Novel compound and composition for preventing or treating neuroinflammatory brain diseases comprising same as active ingredient

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Novel compounds and compositions for targeting at malignant stem cells

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Novel compounds having inhibitory activity against glucosylceramide synthase or pharmaceutically acceptable salt thereof, processes for preparing the same, and pharmaceutical compositions comprising the sam

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Novel compounds having inhibitory activity against glucosylceramide synthase or pharmaceutically acceptable salt thereof, processes for preparing the same, and pharmaceutical compositions comprising the same

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Novel compounds as histone deacetylase 6 inhibitor, and pharmaceutical composition comprising the same

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Novel compounds as histone deacetylase 6 inhibitor, and pharmaceutical composition comprising the same

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Novel compound useful as toll-like receptor 7 activation inhibitor

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Novel compound and pharmaceutical composition comprising same

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Novel compound useful as toll-like receptor 7 activation inhibitor

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Novel compounds derived from schweinfurthins g, e and f

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NOVEL COMPOUND AS mTOR INHIBITOR AND USE THEREOF

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Novel compound and use thereof in treating autoimmune diseases

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Novel compounds derived from schweinfurthins g, e and f

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Novel compounds useful in treating ppar mediated diseases

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Novel compounds useful in treating ppar mediated diseases

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Novel compounds, their preparation and use

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Novel compound, preparation method thereof, and antibiotic composition comprising same

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Novel compounds and their application as positive modulators of ampa-receptors

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Novel compounds as histone deacetylase 6 inhibitor, and pharmaceutical composition comprising the same

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Novel compounds for treating mitochondrial disease

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Novel compounds for the management of aging-related and diabetic vascular complications, process for their preparation and therapeutic uses thereof

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Antagonistic small molecule compound having toll-like receptor 7/9 inhibitory function

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Novel compound having inhibitory activity against pendrin, and pharmaceutical uses thereof

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Novel compounds comprising a new class of transthyretin ligands for treatment of common age-related comorbidities

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Novel compounds and method of preparing a metal-radionuclide-labelled protein

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Novel compounds

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Novel compounds

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Novel compounds

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Novel compounds for the treatment of cancer and inflammatory diseases

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Novel compounds for the treatment of cancer and inflammatory diseases

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Novel compound exhibiting therapeutic effect on inflammatory disease as p38 map kinase inhibitor

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Novel compounds

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Novel compound modulating gsk-3 activity

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Novel compounds for tau imaging

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Novel compound and use thereof for treating emotional behavioral disorders

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Novel compound inducing expression of anti-aging gene klotho

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Novel compound and pharmaceutical composition comprising same for enhancing anticancer activity

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Novel compounds having inhibitory activity on prostaglandin e2 receptor and uses thereof

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Novel compound having skin-whitening, anti-oxidizing and ppar activities and medical use therefor

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Novel compound having skin-whitening, anti-oxidizing and ppar activities and medical use thereof

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Novel compound having therapeutic activity against mycobacterium avium complex infection, and method for producing same

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Compound Having Activity Of Blocking NMDA Receptor Channel, and Pharmaceutical Agent Using The Same

Номер патента: US20090105223A1. Автор: Hiromitsu Takayama,Kazuei Igarashi. Владелец: Chiba University NUC. Дата публикации: 2009-04-23.

Compound having activity of blocking nmda receptor channel, and pharmaceutical agent using the same

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Compound having activity of blocking NMDA receptor channel, and pharmaceutical agent using the same

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Novel compounds having inhibitory activity on prostaglandin E2 receptor and uses thereof

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Novel compounds

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NOVEL COMPOUNDS OF 2-ARYLTHIAZOLE AS AGONISTS OF PPAR α AND PPAR γ

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Novel compound and its pharmacologically acceptable salt

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Novel compounds with antibacterial action

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A novel compound and a novel microorganism for producing the novel compound

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Novel compound promoting osteoblast differentiation and inhibiting adipocyte differentiation, preparation method thereof and application thereof

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Novel compound having cancer metastasis inhibitory activity, preparation method therefor, and pharmaceutical composition for inhibiting cancer metastasis and invasion or treating colorectal cancer, comprising compound

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Novel compounds, isomer thereof, or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and pharmaceutical compositions containing the same

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Novel compounds, isomer thereof, or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and pharmaceutical compositions containing the same

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Nitrogen-containing condensed ring compounds having dopamine D3 antagonistic effect

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Novel compounds and methods of treating cell proliferative diseases, retinopathies and arthritis

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Nitrogen-containing condensed ring compounds having dopamine d3 antagonistic effect

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Nitrogen-containing condensed ring compounds having dopamine d3 antagonistic effect

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Novel compound for degrading target protein or polypeptide by using polyubiquitination

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Novel compounds

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Bicyclic compounds having bradykinin receptors affinity and pharmaceutical compositions thereof

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Methods for synthesizing kotalanol and stereoisomers and analogues thereof, and novel compounds produced thereby

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Methods for synthesizing kotalanol and stereoisomers and analogues thereof, and novel compounds produced thereby

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Compound having inhibitory activity against o-glusacase and use thereof

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Use of novel compound, for preventing, improving or treating amyotrophic lateral sclerosis

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Novel compound produced by means of marine microorganism and composition for improving skin wrinkles, enhancing elasticity and skin whitening comprising same compound as active ingredient

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Novel compounds with analgesic effect

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Compounds having antiinfective, antitumoral and antifungal activity

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Compound having inhibitory activity against o-glcnacase and use thereof

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Novel compounds and their use as prar-modulators

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Novel piperazinylalkylthiopyrimidine derivatives, pharmaceutical compositions containing the same and a process for the preparation of the novel compounds

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Novel compounds as memory enhancers

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Novel compounds for the treatment of mammalian infections

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Novel compounds

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Composition for glomerulopathy treatment and prophylaxis, novel compounds comprising to thereof, pharmaceutical composition for inhibition of matrix metalloproteinases activity and composition for inhibition of collagenases of type iv

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Treating blood or blood product with a compound having a mustard and a nucleic acid binding moiety

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Novel compounds

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Novel compounds and methods for synthesis and therapy

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Novel compounds

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Novel compounds

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Novel compounds

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Novel compounds

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Novel compounds

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Novel Compounds for Treatment of Cancer and Disorders Associated with Angiogenesis Function

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Novel compounds

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Pharmaceutical compositions containing fused-ring 1,4-diazepin derivatives certain such novel compounds and their preparation

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Novel compounds as modulators of glucocorticoid receptors

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Novel compounds, their preparation and use

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Novel compounds

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Novel compound and mri contrast agent containing same

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Novel compound and mri contrast agent containing same

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Novel compound exhibiting therapeutic effect on inflammatory disease as p38 map kinase inhibitor

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Novel compounds

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Novel compounds

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Novel compounds and methods for the treatment of alzheimer's disease and/or cerebral amyloid angiopathy

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Novel compounds that are useful for improving pharmacokinetics

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Novel compounds for the treatment, alleviation or prevention of disorders associated with tau aggregates

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Novel compound as protein kinase inhibitor

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Organic electroluminescence device and novel compound

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Novel compound for light-emitting device, and organic light-emitting device comprising same

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Novel compounds of 11beta-hydroxy-steroids for use in mitochondria biogenesis and diseases associated with mitochondrial dysfunction or depletion

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Novel compound for treatment of severe hypoglycemia

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Composition for anti-diabetes and anti-obesity comprising novel compound

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Novel compound and organic light emitting device using same

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Novel compound for treatment of severe hypoglycemia

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Anti-TNF alpha antibodies which selectively inhibit TNF alpha signalling through the p55R

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Method for preparing biomaterial having selectively functionalized tyrosine, biomaterial having selectively functionalized tyrosine, and pharmaceutical composition containing same as active ingredient

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Pharmaceutical composition possessing antitumour effect, and method for reducing pd-l1 inhibiting effect on human t-cells

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Compound having polycyclic aromatic skeleton, and endoperoxide compound of same

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A screening method to identify agents that selectively inhibit Hepatitis C virus replication in viruses that contain an ISDR region

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Benzoguanamine compound having aminomethyl group, or salt thereof, and method for manufacturing the same

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Diol (meth) acrylate compound having urethane bond, method for producing the same, and polymer thereof

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Diol (meth) acrylate compound having urethane bond, method for producing the same, and polymer thereof

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Diol (meth) acrylate compound having urethane bond, method for producing the same, and polymer thereof

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Diol (meth) acrylate compound having urethane bond, method for producing the same, and polymer thereof

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Method for producing hydride using unsaturated compound having carbon number of 4 as raw material

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(17s)-n-benzyl-5-((3β-acetoxy-28-nor-urs-12-ene)-17-yl)-1,3,4-oxadiazol-2-amine, having selective cell cytotoxicity breast cancer mcf-7

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Compounds having a trichloromethylic end group having a juvenile hormone action on insects and acaricide activity

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Carboxylic acid compound having cyclopropane ring

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Use of carboxylic acid compound having cyclopropane ring as medicament

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Compound having azabenzoxazole ring structure and organic electroluminescent element

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Epoxy compound having alkoxy silyl group, composition comprising same, cured product, use thereof and method for preparing epoxy compound having alkoxy silyl group

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Compound having indenocarbazole ring structure, and organic electroluminescent element

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Compound having affinity substance to antibody and bioorthogonal functional group, or salt thereof

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Compound having a triptycene moiety

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Water-soluble, non-aggregated silicon phtalgcyanine compound having in vitro anticancer effect against cancer types of lung, liver, brest and melanoma

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Method of preparing a ring compound having two adjacent chiral centers

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New fungal strain acremonium sp.mt70646(kctc 8973p) novel compounds produced by this strain and their use

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Process for the preparation of bicyclo hexane compounds and the novel compound demethyl-cis-sabinene hydrate

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Compound having piezoelectric property, piezoelectric device, liquid discharge head using the piezoelectric device, and ultrasonic motor using the piezoelectric device

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Compound having piezoelectric property, piezoelectric device, liquid discharge head using the piezoelectric device, and ultrasonic motor using the piezoelectric device

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Method of obtaining novel 2-2[4-(aminomethyl)phenylpropan-2-ol and this novel compounds as such as well as novel intermediate compounds

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Pharmaceutical composition for treating cancer comprising novel compounds for inhibiting prostaglandin e2 receptor and anticancer drug

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Application of 10-[(3r)-1-azabicyclo[2,2,2]oct-3-ylmethtyl]-10h-phenothiazine for preparing drug selectively inhibiting muscarine receptors m1l, m2 and m3

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Selectively inhibiting estrogen production and providing estrogenic effects in the human body

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Agent having selective action on tumor cells, activating apoptosis thereof and preventing formation of resistance thereof

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Method for selectively inhibiting the activity of acat1 in the treatment of alzheimer's disease

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Method for selectively inhibiting the activity of acat1 in the treatment of alzheimer's disease

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Analogs of shk toxin and their uses in selective inhibition of kv1.3 potassium channels

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Cosmetic or dermatological composition containing compound having hydrogen-linking ability, and method of cosmetic treatment

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Selective inhibition of the membrane attack complex of complement by low molecular weight components of the aurin tricarboxylic acid synthetic complex

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Selective inhibition of cyclooxygenase-2

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Selective inhibition of cyclooxygenase-2

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Method for isolating fraction having anti-inflammatory or osteoarthritis-inhibiting effects by using oyster shell chips

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Method for isolating fraction having anti-inflammatory or osteoarthritis-inhibiting effects by using oyster shell chips

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Composition with endothelin inhibiting effect, preparation method and use thereof

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Compounds having mif antagonist activity

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Compositions comprising compounds having retinol-like activity and a processed oat ingredient

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Compounds having somatostatin-like activity useful as local anti-inflammatory agents

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Process for dyeing the hair comprising the application of a (poly)carbodiimide compound, a compound having at least one carboxylic acid group and a pigment having a particular particle size

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Novel compound and use of said compound

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Novel compound and use of said compound

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Pellet grills having selectable manual cook modes

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Head cover having selectable size and location of opening for exposure of a portion of a user's hair

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Heating member of atomizing device with different heating effects at different portions and atomizing device

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Method and a container for effecting at least one non-lethal change in inherent properties of a non-human biological system under the influence of zero gravity

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2,4-pyrimidindiamine compounds having effect in case of autoimmune disorders

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Compound having exponential temperature dependent electrical resistivity, use of such compound in a self-regulating heating element, self-regulating heating element comprising such compound, and method of forming such compound

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Devices for selectively inhibiting the closure of doors and methods for inhibiting the closure of doors

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Compact printer/feeder having selectable print media modes

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An apparatus to effect at least partial breakdown of a material or product item or a combination of materials or product items

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Method for analysis of low-molecular-weight organic compound having 20 or less carbon atoms in water- and oil-repellent composition

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An apparatus to effect at least partial breakdown of a material or product item or a combination of materials or product items

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Compound having benzazole ring structure, and organic electroluminescent device

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Mobile transceiver having selectable travel modes and a method of operation

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An apparatus to effect at least partial breakdown of a material or product item for a combination of materials or product items

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Bit system having selectably adjustable shank and mouthpiece movement

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Resinous polymer sheet materials having selective, decorative effects

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Membranes having selective permeability

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Electric switches having selectable and adjustable pre-travels

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Method for determining quantity of peptide compound having phenylalanine residue at n-terminus

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Textile with virus-inhibiting effect

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Method of well control under conditions of inertial effect at primary opening of productive oil-gas-saturated stratum

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Charge coupled imaging device having selective wavelength sensitivity

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Data acquisition system having selective communication capability

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Memory devices having selectively electrically connected data lines

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Process for analyzing low molecular weight organic compound having at most 20 carbon atoms in a water/oil repellent compositon

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Methods for predicting an active set of compounds having alternative cores, and drug discovery methods involving the same

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A method for screening compounds having the capacity to control tumor cell invasion or metastasis using constitutively active akt

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Extracted soil movement registration device in places with possible landslide effects at pipeline running route

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System and method for reduction of harmonics effect at system of energy delivery

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Process for analyzing low molecular weight organic compound having at most 20 carbon atoms in cloth made of chemical fibers treated with water and oil repellent agent

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Magnetic recording medium having a binder comprising a copolymer which includes a vinyl compound having a dialkylaminoalkyl group

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Process for regenerating of an adsorbing material in the form of particles charged with at least two volatile compounds having different thermal stabilities

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Silver halide photographic material containing an organic compound having a covalent nitrogen-halogen bond as sensitizer

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Method for forming high sensitivity positive patterns employing a material containing a photosensitive compound having a diazo group, an alkaline-soluble polymer, a compound capable of adjusting the pH to 4 or less and a solvent

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Photopolymerizable mixture including an aromatic compound having terminal (meth) acrylate groups

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Search system for chemical compound having biological activity

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Search system for chemical compound having biological activity

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Methods for predicting an active set of compounds having alternative cores, and drug discovery methods involving the same

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Methods for predicting an active set of compounds having alternative cores, and drug discovery methods involving the same

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Predicting an active set of compounds having alternative cores

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Novel compounds having herbicidal and fungicidal properties and herbicidal and fungicidal compositions containing the said compounds

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COMPOUNDS HAVING ACTIVITY IN CORRECTING MUTANT CFTR CELLULAR PROCESSING

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Novel compounds useful in modulating gene expression of retinoid responsive genes and/or having anti-ap-1 activity

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NOVEL COMPOUNDS

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Novel compounds, isomers thereof or pharmacutically acceptable salts thereof as vanilloid receptor antagonists and pharmaceutical composition containing said compounds

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Complex substituted imidazole compounds having antidote and antihypoxanthic activities

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Novel compounds and uses thereof

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Novel compounds

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A novel compound form

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Novel compounds of thebaine

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Novel compounds and compositions for treating diseases associated with tryptase activity

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Novel compounds and compositions for treating diseases associated with tryptase activity

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NUCLEIC ACID MOLECULE CAPABLE OF BINDING TO 2,4,6-TRINITROPHENYL SKELETON, METHOD FOR DETECTING COMPOUND HAVING 2,4,6-TRINITROPHENYL SKELETON USING THE NUCLEIC ACID MOLECULE, AND USE OF THE NUCLEIC ACID MOLECULE

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Derivatives of amino-7-(chr2r3)-3h,5h-pyrrolo-[3,2-d]-pyrimidine-4-one, methods of their synthesis and a method of selective inhibition of mammalian t-lymphocytes proliferation and no effecting on chr2r3-lymphocytes

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Heterocyclic compounds, having antiproliferative activity and method of slowing down tumour cell proliferation

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Method and system for improved fuel saving and reduced effect at environment in operation of two-stroke engine

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Pyrimidine-4,6-dicarboxylic acid diamides for the selectively inhibiting collagenase (MMP 13)

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Device for stabilisation of power effect at processed surface

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2-mercaptobenzimidazole derivatives having selective anxiolytic activity

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Resinous polymer sheet materials having selective surface decorative effects and methods of making the same

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Hollow fiber assembly having selective permeability

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Resinous polymer sheet materials having selective, surface decorative effects and methods of making the same

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Improvements in Processes of Obtaining Carbon Compounds having the General Formula C10 H16 O.

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Prevention of geo-dynamic effects at underground development of gas-bearing coal seam

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Method for assessment of load parameters effect at deformation process

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Method and device for electrophysical effect at atmosphere

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3-tetrahydronaphthyl-4-hydroxycoumarin compounds having anti-coagulating properties

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Resinous polymer sheet materials having selective, surface decorative effects

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Compounds having super-aspirin effects

Номер патента: IE20110025A1. Автор: Ledwidge Mark,Harmon Shona,Radomski Marek,Francis Gilmer John,O Flynn Pat. Владелец: The Provost Fellows And Scholars Of The College Of The Holy And Undivided Trinty Of Queen Elizabeth Near Dublin. Дата публикации: 2012-08-15.

Flame retardant polyolefin compound having low smoking and toxicity.

Номер патента: MY117351A. Автор: Yasushi Kato,Yukihiko Namiki,Hirofumi Kurisu,Yoshiaki Yokota,Yasunori Kitano,Toshikazu Kotani. Владелец: Tateho Kagaku Kogyo Kk. Дата публикации: 2004-06-30.

Method and device for scanning and local effect at investigated area in biological objects

Номер патента: RU2353922C1. Автор: Алексей Владимирович Федотов,Владимир Владимирович Федотов,Юрий Сергеевич Литвинов,Жанна Юрьевна Нестерова,Ирина Павловна Корнева. Владелец: ФГУ ВПО Российский государственный университет им. И. Канта. Дата публикации: 2009-04-27.

Method and device of acoustic effect at intruder

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Method for otoprotection in case of noise effect at human body

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Process for reaction of epoxides with organic compounds having an active hydrogen

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Flame retardant polyolefin compound having low smoking and toxicity

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Forecasting method of potential toxic effect at joint use of several medical preparations

Номер патента: RU2510533C2. Автор: Юнир Рахимович Абдрахимов,Дмитрий Вячеславович Зейферт,Вера Борисовна Барахнина,Елена Флюровна Гареева. Владелец: Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Уфимский государственный нефтяной технический университет". Дата публикации: 2014-03-27.

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