Process for producing antifungal pyridazinone derivatives and certain novel compounds produced by such a process
Номер патента: CA1199327A
Опубликовано: 14-01-1986
Автор(ы): Hideo Takeshiba, Takao Kinoto, Teruomi Jojima
Принадлежит: Sankyo Co Ltd
Опубликовано: 14-01-1986
Автор(ы): Hideo Takeshiba, Takao Kinoto, Teruomi Jojima
Принадлежит: Sankyo Co Ltd
Реферат: ABSTRACT Process for producing antifungal pyridazinone derivatives and certain novel compounds produced by such a process Compounds of formula (I): (I) [wherein R1 and R3 represent hydrogen or halogen atoms, R2 represents a hydrogen or halogen atom or a lower alkyl or alkoxy group (provided R1, R2 and R3 are not simultaneously hydrogen), represents a single or double carbon-carbon bond and, where it is a single bond, R4 represents a group of formula -SR5 (wherein R5 represents an optionally substituted alkyl, phenyl, aralkyl or pyridyl group or a lower alkenyl group) and, where it is a double bond, R4 represents hydrogen] can be prepared by reacting a compound of formula (II): (II) with a compound of formula R6H [where R6 represents a group -SR5, a group -SR7 (where R7 represents a group of formula or and Y represents oxygen or sulphur, R8 and R9 represent lower alkoxy groups and R10 represents a lower alkoxy, lower alkyl or phenyl group), a methoxy group or a halogen atom] to give a compound of formula (IV): (IV) or, where R6 represents a methoxy group, a methyl ester thereof; reacting this compound with hydrazine to give a compound of formula (V): (V) or (VI):
Process for producing new piperazinylalkyl-3/2h/-pyridazinone derivatives and pharmaceutical compositions comprising same
Номер патента: HUT52094A. Автор: Heimo Stroissnig,Harald Fellier,Rita Enzenhofer,Heinz Blaschke. Владелец: Cl Pharma. Дата публикации: 1990-06-28.