Small molecule imaging of fungi by positron emission tomography scanning
Номер патента: EP3089967A1
Опубликовано: 09-11-2016
Автор(ы): Dale O. Kiesewetter, JIN Qiu, John PANEPINTO, Peter R. WILLIAMSON
Принадлежит: Research Foundation of State University of New York, US Department of Health and Human Services
Опубликовано: 09-11-2016
Автор(ы): Dale O. Kiesewetter, JIN Qiu, John PANEPINTO, Peter R. WILLIAMSON
Принадлежит: Research Foundation of State University of New York, US Department of Health and Human Services
Реферат: Disclosed herein are isotopically labeled calcofluor derivatives and uses of such to detect fungi, such as filamentous fungi, including Aspergillus species, such as by positron emission tomography (PET) scanning. In some examples, the disclosed compounds have a formula of (I) wherein R 1 is an amine, a hydroxyl group, a sulfide, a carboxylic acid, an amide, an alkyl, or aryl; R 2 is -NHC(O)-R 3 -L or -C(O)NH-R 3 -L, wherein R 3 is an aryl or an aliphatic group (such as alkyl); each R 4 independently may be selected from halogen, aliphatic (such as alkyl), aryl, amine, hydroxyl, haloalkyl, carboxylic acid, amide, aralkyl, cyano, ester, thiol, thioether, or alkoxy; each R 5 independently may be selected from hydrogen, aralkyl, alkyl, or aryl, with any one of the aralkyl, alkyl, or aryl groups optionally being substituted with any one of the substituents provided for R 4 ; each n independently is 1, 2, 3, 4, or 5; and L is 18 F or a chelator capable of chelating a radiolabel (such as chelators for [ 18 F]A1F, 64 Cu, 68 Ga), 1,4,7,10- tetraazacyclododecane-tetraacetic acid (DOTA) or 1,4,7-triazacyclononane-triacetic acid (NOTA).
Small molecule imaging of fungi by positron emission tomography scanning
Номер патента: US09968693B2. Автор: JIN Qiu,Dale O. Kiesewetter,Peter R. WILLIAMSON,John PANEPINTO. Владелец: US Department of Health and Human Services. Дата публикации: 2018-05-15.