Engineered soluble decoy receptors to enhance cancer immunotherapy
Номер патента: EP4384280A1
Опубликовано: 19-06-2024
Автор(ы): Ann Marie Leen, Juan Fernando Vera Valdes, Mohsen BASIRI, Pradip BAJGAIN
Принадлежит: Baylor College of Medicine
Опубликовано: 19-06-2024
Автор(ы): Ann Marie Leen, Juan Fernando Vera Valdes, Mohsen BASIRI, Pradip BAJGAIN
Принадлежит: Baylor College of Medicine
Реферат: Disclosed herein are methods and compositions for modulating immune responses by using decoy molecules to bind to soluble or other ligands. In specific embodiments, the decoy molecules comprise a domain that binds to a target immunosuppressive ligand and another domain that releases immunostimulatory signals when activated. In specific embodiments, the decoy molecules are soluble and are secreted by transgenic T cells at a tumor site, such as upon antigen engagement, and they protect the transgenic cells themselves and also bystander ( e.g. , non-modified) endogenous immune cells.
A mixture of mrna to enhance the potency of dendritic cells
Номер патента: CA3175630A1. Автор: Kris Thielemans. Владелец: Vrije Universiteit Brussel VUB. Дата публикации: 2021-09-23.