Biomimetic coating for endovascular stent
Номер патента: CA3241253A1
Опубликовано: 08-06-2023
Автор(ы): Antonino Nicoletti, Charles SKARBEK, Christophe Bureau, Giuseppina Caligiuri, Isabelle LEFEVRE
Принадлежит: Alchimedics SAS, Institut National de la Sante et de la Recherche Medicale INSERM, Université Paris Cite, Universite Sorbonne Paris Nord Paris 13
Опубликовано: 08-06-2023
Автор(ы): Antonino Nicoletti, Charles SKARBEK, Christophe Bureau, Giuseppina Caligiuri, Isabelle LEFEVRE
Принадлежит: Alchimedics SAS, Institut National de la Sante et de la Recherche Medicale INSERM, Université Paris Cite, Universite Sorbonne Paris Nord Paris 13
Реферат: Inventors have synthesized peptides allowing an engagement of intact CD31 molecules on all the healthy endothelial cells and resting blood platelets and leukocytes that can enter in contact with an implanted device. Those cells can therefore receive the "leave-me-alone" signal delivered by the trans-homophilic engagement of CD31, which is essential to maintain the homeostasis in the circulation and vascularized tissues. Thrombotic or life-threatening occurrence of hemorrhagic or thromboembolic complications have impaired the use of endovascular devices. The devices bearing the mimicking peptides of the present invention are rapidly integrated, because they are perceived by blood platelets and leukocytes as a healthy endothelium, a "self' component. Furthermore, their ability to be rapidly endothelialized with a physiologic endothelial cell phenotype also limits platelet and leukocyte activation at the site of device implantation in the long-term. Accordingly, the present invention relates to peptides mimicking the trans-homophilic CD31-CD31 domain 1 and 2 intercellular interaction.
Surface-oriented antibody coating for the reduction of post-stent restenosis
Номер патента: CA2751947C. Автор: Michael Thompson,Christophe Blaszykowski,Pasquale Benvenuto. Владелец: ECONOUS SYSTEMS Inc. Дата публикации: 2018-10-16.