Five membered heterocyclic ring containing n-(bicyclic heterocyclyl)-4-piperidinamines.

Five membered heterocyclic ring containing n-(bicyclic heterocyclyl)-4-piperidinamines

Номер патента: ZW16484A1
Опубликовано: 30-04-1986
Автор(ы): Eduard Janssens Frans, Francis Hens Jozef, Leo Ghislanus Torremans Joseph, Theresia Joannes Theophilus, Van Offenwert Maria
Принадлежит: Janssen Pharmaceutica NV

Рисунок 1. Взаимосвязь патентов (ближайшие 20).

Five membered heterocyclic ring containing n-(bicyclic heterocyclyl)-4-piperidinamines

Номер патента: PT79307A. Автор: . Владелец: Janssen Pharmaceutica NV. Дата публикации: 1984-11-01.

Five membered heterocyclic ring containing n-(bicyclic heterocyclyl)-4-piperidinamines

Номер патента: PH21310A. Автор: Janssens Frans,Torremans Joseph,Hens Josef,Offenwert Van Theophilus. Владелец: Janssen Pharmaceutica NV. Дата публикации: 1987-09-28.

N- (BICYCLEIC HETEROCYCLYL) -4-PIPERIDINAMINES

Номер патента: DK478484A. Автор: Frans Eduard Janssens,Joseph Leo Ghislanus Torremans,Theophilus Theresia Offenwert,Joseph Francis Hens. Владелец: Janssen Pharmaceutica NV. Дата публикации: 1985-04-07.

Novel n-(bicyclic heterocyclyl)-4-piperidinamines

Номер патента: DE3369784D1. Автор: Frans Eduard Janssens,Joseph Leo Ghislanus Torremans,Jozef Francis Hens,Offenwert Theophilus There Van. Владелец: Janssen Pharmaceutica NV. Дата публикации: 1987-03-19.

Process for preparation of n-(bicyclic heterocyclyl)-4-piperidinamines

Номер патента: KR870001510B1. Автор: 쟈안센 프란스,헨스 죠제프,토오레마스 죠세프,판 오펜워드 테오프닐스. Владелец: 폴 아드리안 잔 쟈안센. Дата публикации: 1987-08-20.

Novel n-(bicyclic heterocyclyl)-4-piperidinamines

Номер патента: EP0099139A3. Автор: Frans Eduard Janssens,Joseph Leo Ghislanus Torremans,Jozef Francis Hens,Theophilus Theresia J.M. Van Offenwert. Владелец: Janssen Pharmaceutica NV. Дата публикации: 1984-02-22.

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METHOD FOR PREPARING THE SUBSTITUTED ISOTHYOL1 UCHEVIN1 The invention relates to the method of obtaining the derivatives of amides, in particular the substituted isothiourea, which has pharmacological activity. The proposed method for producing a substituted isothiourea of the general formula .- ^^ - (^ E,}, t ^ '(^^^^' "X_LASR ^ where X is hydrogen, lower alkyl, amino or lower alkylthio; b ^ 1; n - 2-5; R— hydrogen, Ci — 4-, alkyl, aryl, or aralkyl; R * is saturated or unsaturated Ci — Cb-alkyl or (CH2) mZ, where m is 1-3; Z is substituted or unsubstituted aryl, hydroxyl, carboxyl, alkyl ^ mino or cyano group; R and R ^ together can form a 5-membered ring; 2A together with the adjacent carbon and nitrogen atoms is an unsaturated 5-6 membered heterocyclic ring, based on the well-known alkylation reaction of group 5 - C = S and consists in the fact that the thiourea of the general formula /? NK. "South": '™' ^^ Agde A, X, B, n and R have the above meanings, are treated with a compound of general 15 of the formula R'Y, where R 'is as indicated above; Y is halo or hydroxyl, and the target is isolated the product is in the form of a salt or is converted into the base by known methods. 20 The starting thiourea is used as an acid addition salt, for example, with a halogen-hydrogen, sulfuric, picric or maleic acid, or is carried out in the presence of one of these acids. organic solvent, such as ethyl alcohol, dimethylformamide, or acetone. uyuschies isothiourea addition salts converted to the base in the processing 30 for example, potassium carbonate.

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