Methods of lipid nanoparticle manufacture and compostions derived therefrom
Номер патента: EP4229208A1
Опубликовано: 23-08-2023
Автор(ы): Drew Weissman, Manuel Carrasco, Michael Daro BUSCHMANN, Mikell Paige, Mohamad Gabriel ALAMEH, Suman Alishetty
Принадлежит: George Mason Research Foundation Inc, University of Pennsylvania Penn
Опубликовано: 23-08-2023
Автор(ы): Drew Weissman, Manuel Carrasco, Michael Daro BUSCHMANN, Mikell Paige, Mohamad Gabriel ALAMEH, Suman Alishetty
Принадлежит: George Mason Research Foundation Inc, University of Pennsylvania Penn
Реферат: Disclosed herein are methods of increasing the potency of nucleic acid loaded lipid nanoparticles (naLNPs) through certain novel and surprisingly superior LNP manufacturing techniques. Also disclosed are pharmaceutical compositions containing naLNPs manufactured according to the manufacturing methods described herein. The methods disclosed herein overcome major technical difficulties and high costs associated with previous LNP manufacturing techniques. The methods disclosed herein, therefore, greatly improve the industrial production of LNPs in unexpected ways thereby providing more potent naLNPs for nucleic acid delivery. Specifically, the invention disclosed herein are methods that show increased potency naLNPs due to increased mixing concentration of the lipids and mRNA during assembly.
Ionizable lipids and methods of manufacture and use thereof
Номер патента: EP4228658A1. Автор: Mikell Paige,Drew Weissman,Mohamad Gabriel ALAMEH,Suman Alishetty,Michael Daro BUSCHMANN,Manuel Carrasco. Владелец: George Mason Research Foundation Inc. Дата публикации: 2023-08-23.