Antisense oligonucleotides to inhibit angiogenesis and/or metastasis
Номер патента: EP1299533A2
Опубликовано: 09-04-2003
Автор(ы): Amy Wong, John Nip, Pnina Brodt
Принадлежит: McGill University
Опубликовано: 09-04-2003
Автор(ы): Amy Wong, John Nip, Pnina Brodt
Принадлежит: McGill University
Реферат: The present invention relates to a novel class of inhibitors of angiogenesis and/or metastasis that targets cell adhesion molecules, and more particularly to antisense phosphorothioate oligonucleotides directed to a subunit of an integrin vitronectin receptor to inhibit angiogenesis and/or metastasis. There is provided an antisense phosphorothioate oligonucleotide directed to one of a αv, β3 and β5 subunit of an integrin vitronectin receptor. The antisense phosphorotihioate oligonucleotide blocks synthesis of the integrin vitronectin receptor on a target cell, thereby inhibiting angiogenesis and/or metastasis. There is provided a method for blocking angiogenesis and/or metastasis in a patient, comprising delivering an efficient amount of such an antisense phosphorothioate oligonucleotide to the target cell of the patient, thereby blocking synthesis of the integrin vitronectin receptor on the target cell and blocking angiogenesis and/or metastasis.
Antisense oligonucleotides to inhibit angiogenesis and/or metastasis
Номер патента: WO2002000877A3. Автор: Pnina Brodt,Amy Wong,John Nip. Владелец: John Nip. Дата публикации: 2002-12-27.