Vibrio cholerae strains vcusm1 and vcusm4, method of producing same, and vaccine derivatives thereof
Номер патента: MY142562A
Опубликовано: 15-12-2010
Автор(ы): Lalitha Pattabiraman, Manickam Dr Ravichandran, Nur Haslindawaty Abdul Rashid, Syed Atif Ali, Zainul Fadziruddin Zainuddin
Принадлежит: Univ Sains Malaysia
Опубликовано: 15-12-2010
Автор(ы): Lalitha Pattabiraman, Manickam Dr Ravichandran, Nur Haslindawaty Abdul Rashid, Syed Atif Ali, Zainul Fadziruddin Zainuddin
Принадлежит: Univ Sains Malaysia
Реферат: METABOLIC AUXOTROPH OF VIBRI0 CHOLERAE 0139 SYNONYM BENGAL WHCH HAS A MUTATION IN ITS HEM A GENE AND WHIHC IS NOT CAPABLE OF SYNTHESIZING AMINOLEVULINIC ACID (ALA) DE NOVO AND WHICH IS OBTAINED FROMA PARENT STRAIN ORIGINALLY ISOLATED FROM A PATIENT'S COPROCULTURE HAVING ALL THE IDENTIFYING CHARACTERISTICS OF VIBRIO CHOLERAE 0139 SYNONYM BENGAL IS DESCRIBED.IN THIS STRAIN THE HEM A GENE IS MUTATED BY INSERTING A KANAMYCIN RESISTANT GENE CASSETTE. ANOTHER METABOLIC AUXOTROPH OF VIBRIO CHOLERAE 01 E1 TOR WHERE THE HEM A GENE IS MUTATED BY A FRAME SHIFT MUTATION IS DISCLOSED. METHODS OF PRODUCING THE STRAINS ARE DISCLOSED.
Method for identification of vibrio-cholerae o1 strains, determination of their toxigenicity and biovar with differentiation of el tor biovar on typical and genetically changed versions by multiplex polymerase chain reaction and test system for implementation thereof taking into account results in real time mode
Номер патента: RU2732448C9. Автор: Дмитрий Анатольевич Ковалев,Вилорий Николаевич Савельев,Ирина Вилорьевна Савельева,Василий Валерьевич Сосунов,Екатерина Ивановна Подопригора,Оксана Васильевна Васильева,Людмила Вадимовна Гусева. Владелец: Федеральное казённое учреждение здравоохранения Ставропольский научно-исследовательский институт Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека. Дата публикации: 2021-05-26.