Maleamic acid derivatives
Реферат: The invention comprises compounds of formula <FORM:1014889/C2/1> wherein R is a methylene, ethylene or propylene radical optionally substituted by C1- 10 alkyl, cycloalkyl or aryl groups, and their preparation by reaction of the appropriate naphthyl-alkylamine with maleic anhydride. The compounds of the invention have pharmaceutical activity (see Division A5). Naphthylalkylamine starting materials are prepared by reaction of a carbonyl compound with formamide and formic acid. 1 - (1 - Naphthyl) - 1 - hexanone or pentanone are prepared by reaction of 1-naphthyl cyanide with amyl or butyl magnesium bromide to form the corresponding ketimine, which is then hydrolysed.ALSO:Pharmaceutical compositions for administration in conjunction with penicillin and having uric acid-excretion enhancing and blood-cholesterol-lowering activity comprise compounds of formula <FORM:1014889/A5-A6/1> wherein R is a methylene, ethylene or propylene radical optionally substituted by C1-10 alkyl, cycloalkyl or aryl groups, in dosage form, optionally in combination with a carrier, for example in forms suitable for oral or parenteral administration, such as tablets, capsules, pills or solutions.
Method of producing optically active n-(halopropyl) amino acid derivative
Номер патента: US20110190527A1. Автор: Toru Inoue,Jun Matsumoto. Владелец: Nagase and Co Ltd. Дата публикации: 2011-08-04.