Hydrophobic interaction chromatography-coupled native mass spectrometry for antibody analysis
Номер патента: ZA202302763B
Опубликовано: 28-08-2024
Автор(ы): Shunhai WANG, Yuetian Yan
Принадлежит: Regeneron Pharma
Опубликовано: 28-08-2024
Автор(ы): Shunhai WANG, Yuetian Yan
Принадлежит: Regeneron Pharma
Реферат: The present invention provides rapid, sensitive high-throughput methods and systems for characterizing peptides or proteins using hydrophobic interaction chromatography-coupled native mass spectrometry to improve manufacturing process of biopharmaceutical products, such as identifying impurities during antibody purification, monitoring post-translational modification variants during production, or characterizing drug-to-antibody ratio of antibody-drug conjugates. The separation profiles of the peptides or proteins are generated and compared to identify or qualify the peptides or proteins.
Hydrophobic interaction chromatography-coupled native mass spectrometry for antibody analysis
Номер патента: ZA202203400B. Автор: Yuetian Yan,Shunhai WANG. Владелец: Regeneron Pharma. Дата публикации: 2024-01-31.