COMPOSITION FOR PREVENTING, AMELIORATING, OR TREATING ATOPIC DERMATITIS INCLUDING SCHISANDRA LEAF EXTRACT AS ACTIVE INGREDIENT

Therefore the present invention refers to pharmaceutical compositions for preventing or treating atopic dermatitis including leaf extracts of the active ingredient are disclosed.

Therefore including method steps is a number by said leaf extracts of the tank can be a, does not limited to:

1) Extracting the extraction solvent therefore leaves dry powder applied;

2) Step 1) extract of filtering step; and

3) Step 2) filtering extract cream and dried to extract step number tank.

Said step 1) extracted from the solvent can be water, C₁ - C₄ Scattering is preferably alcohol or mixture thereof, more preferably ethanol extract but not limited.

In said manufacturing method, therefore leaf extraction is propylene, human health, immersion extraction, extraction and ultrasonic extraction to all publicly known conventional method such as reflux cooling per industry can be using. Said step 3) the decompression of enrichment is using vacuum cream or vacuum rotary Eq preferably does not limited. In addition, drying reduced pressure drying, vacuum drying, boiling drying, preferably spray-dried or lyophilized does not limited.

In addition to the active ingredient of the present invention said composition is a pharmaceutically acceptable carrier, excipient or dilution number can be further includes a number, can be oral or parenteral various number type. If filling normally used under anger number number number, a specific number, number coupled, wet number, number disintegrating, dilution number or excipients such as surfactants using tank number number number with each other. The encapsulation number number number solid for oral administration, acid number, granules number, positive number, number or the like included in a ring, at least one excipient such solid number number number for example one or more of the compounds, starch, calcium carbonate, sucrose (sucrose) or lactose (lactose), gelatin tank pressure is lowered number with each other. In addition, simple number excipients in addition to the magnesium salt of stearic acid, talc such as lubricating number are also are used. Number number for oral administration include liquid suspension, emulsion, syrup, aerosol and the like to a simple dilution number corresponding commonly used in water, in addition to the paraffin droplet number various excipients, for example wet number, sweetener number, direction number, number and the like can be preserved. For parental administration number number is a sterile aqueous solution, non-aqueous for number, number suspension, oil number, freeze-dried number number, number left multiple myelomas are included. For number include propylene glycol (propylene glycol) and number for non-aqueous suspension, polyethylene glycol, vegetable oil such as olive oil, such as the [ley which comes the [thu and ethyl ester is used as the injectable can be. As above [theyp brush left number for number (witepsol), mark with goal, twin (tween) 61, carcass five fingers, that it soaked, can be preparing gelatin is used as the alkali. Either intraperitoneally or external skin upon parenteral administration, rectal, intravenous, muscle, subcutaneous, intrauterine epidural or cerebrovascular in selecting scan mode is preferably, most preferably a skin preparation for external use other.

The present invention according to a therapeutically effective pharmaceutical compositions is administered in an amount about number. In the present invention, "a therapeutically effective amount about number" rational possibility [hyey/ risk ratio applicable to medical treatment in an amount sufficient to treat conditions which means, the level of patient effective type of disease, the severity, drug, drug sensitivity, administration time, routes and discharge ratio, a treatment period, simultaneous use the sealed elements and other medical fields can be determined according to well-known element. Composition of the present invention individual treatment or administration of other therapeutic number number on with administration of treatment on number of the existing method can be sequential or concurrent administration also can be, can be single or multiple administration. Said components can be obtained in an amount of at least excellently considers both the maximum effect the amount administered important, this can be determined by one skilled for hereinafter.

Body weight of patients doses of the present invention composition, age, sex, health condition, dietary, administration time, administration method, excretion rate range along with a variety of severe diseases and which generates, based on the amount of leaf extracts of the daily dosage is therefore 0. 01 Provided 2,000 mg/kg and, preferably and 30 provided 500 mg/kg, more preferably 50 provided 300 mg/kg and, by administering a single day 1 - 6 can be. Of the present invention composition alone or in combination with surgery, radiation therapy, hormone therapy, using chemotherapeutic and biological reaction control number method and can be used in combination with.

In addition, the present invention refers to active ingredient including atopic dermatitis for preventing or ameliorating therefore leaf extracts of non-food composition are disclosed.

Said health nutraceutical composition powder, granules, ring, positive number, capsule, candy, beverage syrup of selected among any number preferably but not the limited number-bath. Health food composition of the present invention when used for food additives, therefore either adding said second leaf extracts of food or food ingredients can be used with other, conventional method can be suitably according. The amount of active ingredient (prevention, health or therapeutic treatment) according to object of use can be determined. Generally, the food or beverage of the present invention hereinafter provided to maintain a number of morning fair 15 parts by weight of composition, preferably in an amount of 10 parts by weight of hereinafter are included. However health and hygiene purposes or in the case of ingestion of the amount said range said health control can have long term is hereinafter, door number because as the active ingredient in the aspect of safety insofar as an amount of at least said range can be also be used. Said type of food is simplified and a smooth free number. Performance examples of said food meat, sausage, bread, chocolate, candy, snack, confectionery, pizza, if, other noodles, gum type, ice cream acid number a dairy product, various soup, beverage, difference, drinkable number, alcoholic drinks and vitamin complex and the like, health food comprising both in conventional meaning.

Health beverage composition of the present invention functions, lower number or natural carbohydrate is like conventional beverage flavor can be additional active ingredient. The above-described natural carbohydrate glucose, oligosaccharides such as mono pathogenic agent, liver, such as shoe cross and d company kara id, indoline full text, such as cyclo [theyn with [su phosphorus polysaccharide, xylitol, sorbitol, such as processes for the preparation of party alcohol among others. As sweetener number TAU denaturing detergent, such as Stevia extract or natural sweetener number, saccharin, oh [su group [lu with burning, can be use such as synthetic sweetener number. The ratio of said natural carbohydrate of the present invention composition per 100g generally about 0. 01 - 0. 04G, preferably about 0. 02 - 0. 03G are disclosed. In addition to said nutritional composition includes number of the present invention, vitamin, electrolyte, flavor number, colored number, [pheyk the [thu it buys and salts thereof, alginic acid and salts thereof, organic acid, protective colloidal point number, pH control number, stabilizing number, antiseptic number, glycerin, alcohol, number of calcium hydroxide can be used in carbonated beverages and the like. In addition to of the present invention composition comprises natural fruit juice, fruit juice beverage and vegetable beverages containing pulp can be of number for numerical control machine. These components can be used independently or mixing. The triazines of the present invention per 100 parts by weight of composition ratio of added significant but not large number 0. 01 - 0. 1 Parts by weight of generally is selected from the range are disclosed.

In addition, the present invention refers to active ingredient therefore improve itch of atopic dermatitis including leaf extracts of the cosmetic composition are disclosed.

Said composition solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, number - surfactants containing cleansing, oil, powder foundation, emulsion, foundation, selected among any number number bath-wax foundation and spraying preferably but not the limited.

In the case of cosmetic composition of the present invention solution or emulsion-solvent carrier ingredient number, solvating number or number is used device for cleaning, for example water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1, 3 - butyl glycol oil, glycerol aliphatic ester, polyethylene glycol or sorbitan fatty acid esters flow tides.

Cosmetic composition of the present invention number type suspension carrier ingredient when water, such as ethanol or propylene glycol liquid dilution number, box-ethoxylated alcohol, polyoxyethylene sorbitol esters and polyoxyethylene sorbitan ester such as suspension number, microcrystalline cellulose, aluminum meta , bentonite, agar or coating such as space [thu can be used.

Cosmetic composition of the present invention number type paste, cream or when it is a gel carrier ingredient animal fiber, plant fiber, wax, paraffin, starch, space [thu coating, cellulose derivative, polyethylene glycol, silicon, bentonite, silica, talc or zinc oxide or the like can be used.

Cosmetic composition of the present invention this powder or spray when the number type carrier ingredient lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder can be used, in particular when the additionally chloro spray, such as a butane or dimethyl ether can be - propane to expel the projectile.

Cosmetic composition of the present invention the interface number when the number type carrier ingredient aliphatic alcohol containing cleansing - active sulfate, aliphatic alcohol ether alkylsulfate, sulfonyl succinic ester, oh three motes this [thu which comes, imidazole derivatives, methyl , cooperates with the disadvantages, fatty acid amide ether sulfate, alkyl polyglycoside, aliphatic alcohol, fatty acid glyceride, fatty acid d ethanol amide, vegetable oil, ethoxylated glycerol fatty acid ester can be used it teased derivative or the like.

In addition to the active ingredient of the present invention same or similar cosmetic composition further indicating a function of atopic dermatitis at least one ingredient containing 1 can be improved.

Cosmetic composition of the present invention can be directly applied to the skin like biodegradable microneedle or patch.

In addition, the present invention refers to compositions including improving atopic dermatitis medicine external width therefore leaf extracts of the active ingredient are disclosed.

In the present invention, human or animal diseases "medicine external width composition", relief, for purposes of treatment or prevention of fiber, rubber number article or the like, does not acting directly on human action to the weak or human, or machine is determined not and the like, for preventing infection of a conductive polymer composition, insecticidal and similar application in number number corresponding to one of the article, person or animal diagnosis of disease, treatment, alleviation, treatment or preventing article purposes during mechanism, machine or device and not the structure used in a person or animal pharmacological function adversely affect the article during mechanism, machine or device is determined not article and a number means, specifically skin preparation for external use number or personal care article can be a, the number is not one. Medicine external width composition of the present invention may indicate various improving atopic dermatitis comprising if can be weight %, preferably 0. 00001 To 10% by weight can be said.

Hereinafter, the present invention broadcast receiver using more detailed in the embodiment. In the embodiment of the present invention is more specifically describe the present invention only these for the number one is a person with skill in the art that these range by not notified to the reduced in the art are disclosed.

In the embodiment 1. Therefore number of leaf extracts of the bath

Therefore leaves for 1 kg of dry powder, 15 l of 70% ethanol (v/v) applying, in the extract of 85 °C 3 hours reflux, reducing pressure in the concentrated liquid filtering 50 °C, therefore drying leaf extracts of yesterday.

In the embodiment 2. Cells Survival rate Analysis

MC/9 cells 24 hours according to each sample concentration dilution and processing, MTT assay microplate reader (Molecular Devices, Sunnyvale, CA, USA) in a predetermined cell survival rate to 550 nm were measured.

As a result, the disclosure therefore also 1 as fruit, leaf and stem extract not cytotoxic both in low resolution.

In the embodiment 3. Antihistamine effect analysis

48 Well plate divider PMA concentration a MC/9 cells (50 nm) on A23189 (1 μm) processing, therefore a clover leaf extracts of the present invention therefore fruit extracts compared by and has the stem extract concentration (25, 50, 100 micro g/Ml) to treatment with him as 24 hours. After histamine ELISA assay kit using culture supernatants that it according to the method of the radiation amount number histamine (histamine) were measured.

As a result, the disclosure also 2 as both schizandra fruit extract concentration depending on the histamine reduced concentration of 24.4, therefore in particular leaf extract, schizandra fruit extracts or confirming the histamine content of the reduced stem extract therefore significant advantages over the first call request.

In the embodiment 4. Measuring NO

48 Well plate divider RAW 274 a specific concentration. 7 Leaf extracts of the embodiment of the present invention cells therefore compared by therefore fruit extract concentration (25, 50, 100 micro g/Ml) after treated with LPS (500 ng/Ml) 24 him as time for processing. The Griess method of the radiation over a number after culture supernatants that it using an assay reagent NO amount were measured.

As a result also 3 as to disclosure, therefore the amount of leaf extracts of the NO induced by LPS treatment significantly reduced.