COMPOSITION FOR SKIN WHITENING COMPRISING EXTRACT OF ROASTED ALPINIA KATSUMADAI SEMEN AS EFFECTIVE COMPONENT

The present invention refers to a skin-whitening cosmetic composition including nine seconds dihydroxyflavanone extract are disclosed. Of the present invention nine seconds dihydroxyflavanone dihydroxyflavanone (Alpinia katsumadai) Number of mature rolled so that information for a stand-alone after producing an powdered rind are disclosed. The powder of the present invention is characterized by heating a tea with nine seconds dihydroxyflavanone, clothing or clothing temperature time particularly number does not relayed.

Said dihydroxyflavanone nine seconds to process the extract by high pressure liquid coolant including method number but, not limited to:

(1) Extracting dihydroxyflavanone nine seconds applied to extraction solvent;

(2) Step (1) extract of filtering step; and

(3) Step (2) extract cream and dried to extract number bath filtering step.

Said step (1) extracted from the solvent can be water, C₁ - C₄ Selecting one of lower alcohols or mixtures thereof is preferably, more preferably C₁ - C₄ Of lower alcohols and, further preferably 70% (v/v) ethanol but not limited.

In said manufacturing method, extraction method is filtration, heat extraction, immersion extraction, extraction and ultrasonic extraction to all publicly known conventional method such as reflux cooling per industry can be using. Said extraction solvent extraction dried dihydroxyflavanone added is preferably 1 - 20 times weight of nine seconds, more preferably 5 - 15 adding times are disclosed. Extraction temperature preferably 4 to 50 °C does not limited. In addition, extraction time is 0. 5 - 10 Times of the preferably, 0. 5 - 5 And more preferably in a limited time does not. In said method, step (3) the decompression of enrichment is using vacuum cream or vacuum rotary Eq preferably does not limited. In addition, drying reduced pressure drying, vacuum drying, boiling drying, preferably spray-dried or lyophilized does not limited.

It is sour with the mote but oh number (tyrosinase) which inhibit the activity of said composition characterized, production of melanin (melanin) billion industry number or number of enterocin hj35. parasitic preformed melanin.

On the other hand, the other frequency whitening effect, ultraviolet ray, hormone balance change, such as a genetic program produced by skin factor well! [mwus under melasma, freckles, improving or preventing a dark circle effect, the transparent feeling beautiful skin having a thickness of 1, maintaining the beautiful skin effect or a transparency, under [chik furthermore by reducing the effect of increasing the skin taut like etc. it is intended. Generally, skin or well! [mwus under melasma, freckles, the dark circle by UV irritation and hormone balance and by variation of oligonucleotide (melanocyte) is stimulated, thus depositing preformed melanin biosynthetic generated there if known. The, number billion can do the generation of melanin, or skin well! [mwus under melasma, freckles, improve preventive process from a dark circle.

Cosmetic composition of the present invention solution, emulsion, suspension, paste, cream, gel, powder, spray, number - surfactants containing cleansing, lotion, soap, oil, powder foundation, foundation and wax foundation preferably selected among any number type.

In the case of cosmetic composition of the present invention solution or emulsion-solvent carrier ingredient number, solvating number or number is used device for cleaning, for example water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1, 3 - butyl glycol oil, glycerol aliphatic ester, polyethylene glycol or sorbitan fatty acid esters flow tides.

Cosmetic composition of the present invention number type suspension carrier ingredient when water, such as ethanol or propylene glycol liquid dilution number, box-ethoxylated alcohol, polyoxyethylene sorbitol esters and polyoxyethylene sorbitan ester such as suspension number, microcrystalline cellulose, aluminum meta , bentonite, agar or coating such as space [thu can be used.

Cosmetic composition of the present invention number type paste, cream or when it is a gel carrier ingredient animal fiber, plant fiber, wax, paraffin, starch, space [thu coating, cellulose derivative, polyethylene glycol, silicon, bentonite, silica, talc or zinc oxide or the like can be used.

Cosmetic composition of the present invention this powder or spray when the number type carrier ingredient lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder can be used, in particular when the additionally chloro spray, such as a butane or dimethyl ether can be - propane to expel the projectile.

Cosmetic composition of the present invention the interface number when the number type carrier ingredient aliphatic alcohol containing cleansing - active sulfate, aliphatic alcohol ether alkylsulfate, sulfonyl succinic ester, oh three motes this [thu which comes, imidazole derivatives, methyl , cooperates with the disadvantages, fatty acid amide ether sulfate, alkyl polyglycoside, aliphatic alcohol, fatty acid glyceride, fatty acid d ethanol amide, vegetable oil, ethoxylated glycerol fatty acid ester can be used it teased derivative or the like.

In addition to the active ingredient of the present invention cosmetic composition further containing at least one same or similar indicating a function which can be skin whitening active 1. Skin whitening active ingredients include kojic acid and derivatives thereof, arbutin, ascorbic acid and derivatives thereof, hydroquinone and derivatives thereof, resorcinol, 1 alkanone, methylenedioxy phenyl alkanol, 2, 7 - it will rise with the d knit and it will doze or composition for orange extract, rice extract, such as extract plant extract is provided to be used, the one number are not disclosed.

Cosmetic composition of the present invention fluorescent materials, fungicidal number, hydrotropism inducing material, moisturizing number, direction number, direction number carrier, protein, solubilized number, sugar derivative, sunscreen number, vitamin, plant extract can be further including excipients like number.

In addition, the present invention refers to extract excessive melanin deposition for prevention or treatment of diseases including nine seconds dihydroxyflavanone pharmaceutical compositions are disclosed.

The specification the term "excessive melanin deposition (hyperpigmentation)" used in skin or hand, at a specific site of the nail relative to the gum will be darker or in another portion by increased excessive melanin which means that the other. Said excessive melanin deposition disease is freckles, age spots, , melasma, brown or NaCI, sunlight dye semi, Prunsoop black blood symptoms (cyanic melasma), drug utilization of excess pigmentation, pregnancy-brown semi (gravidic chloasma), or scratch wound or dermatitis after inflammation due to excessive pigmentation and Image including but not limited to like.

In addition to the active ingredient of the present invention pharmaceutical compositions comprising a pharmaceutically acceptable carrier can be, when such carrier number number as typically used, lactose, dextrose, sucrose, sorbitol, mannitol, starch, acacia rubber, calcium phosphate, alginate, gelatin, calcium silicate, microcrystalline cellulose, polyvinylpyrrolidone, cellulose, water, syrup, methyl cellulose, methyl hydroxy benzoate, propyl hydroxy benzoate, talc, magnesium and mineral oils and the like acid including but, limited to are not correct. In addition to the components of the present invention pharmaceutical compositions unexpectedly give rise said lubricating number, wet number, number sweetener, flavor number, number emulsion, suspension number, number further comprises preserving such as can be. Suitable pharmaceutically acceptable carrier and number number is the [ley it shook off pharmaceutical science (Remington's Pharmaceutical Sciences, 19th ed. , 1995) Disclosed detailed.

Pharmaceutical compositions of the present invention according to suitable dosage is number number method, administration scheme, patient's age, weight, -, pathological conditions, food, administration time, routes, such as sensitive and reaction speed is determined by the various prescribed for a printed wiring board can be. On the other hand, a pharmaceutical composition of the present invention per dose is preferably 1 0. 0001 Provided 100 mg/kg (body weight) are disclosed.

Pharmaceutical compositions of the present invention can be oral or parenteral administration, in the case of parenteral administration, skin by topical application, intravenous injection, subcutaneous injection, muscle injection, abdominal implantation, such as transdermal administration can be administered. Pharmaceutical compositions of the present invention treat or prevent diseases or excessive melanin deposition adapted in view of the point, preferably in that is topically applied to the skin.

The concentration of the active principle included within the composition of the present invention therapeutic purposes, patient state, polarity can be determined within a particular range of concentration required period is not limited.

Pharmaceutical compositions of the present invention in the embodiment for the invention hereinafter is provided to person with skill in the art is capable according to method, pharmaceutically acceptable carrier or excipient prepared under anger unit dose form or otherwise by using number number number number number 1308. amount container ingrowth to bath tank. The number may be scanning number, cream, patch, spray number, number ointment, warning number, lotion number, candle number, number and any number-number number selected from plasma catadioptric pasta can also be bath and, number or stabilizing number can be further dispersed.

In addition, the present invention refers to nine seconds dihydroxyflavanone extract including health food composition for treatment or prevention of excessive melanin deposition are disclosed.

Health food composition of the present invention when used for food additives, either adding said second health food composition can be use with other food or food ingredients, can be suitable for use according to the conventional method. Mixing of active ingredient suitable for use in accordance with the aim of use german silver (preventing or ameliorating) can be. Generally, health food composition of the present invention hereinafter provided to maintain a number of morning fair food or beverage 15 parts by weight, preferably hereinafter are included in an amount of 10 parts by weight. However health and hygiene purposes or in the case of ingestion of the amount said range said health control can have long term is hereinafter, door number because insofar as in the aspect of safety as the active ingredient can be used in a quantity of said range.

Said special number smooth free type of health food. Said food health food composition can be added examples of meat, sausage, bread, chocolate, candy, snack, confectionery, pizza, if, other noodles, gum type, ice cream acid number a dairy product, various sprocket, beverage, tea drink number, such as alcoholic beverages and vitamin composite number may be, health food comprising both in conventional meaning.

In addition, health food composition of the present invention in food, in particular ethanol bath number can be disclosed. Number upon tank of the present invention functional food product includes ingredients which add to conventional ones, e.g., protein, carbohydrate, fat, nutrient and seasoning comprising the following number. For example, if in addition to the natural carbohydrate or flavor number number number bath to drink ingredient capable of further active ingredient. Natural the carbohydrate (e.g., glucose, such as fructose) said pathogenic agent mono, d company kara id (for example, liver, sucrose or the like), oligosaccharide, polysaccharide (e.g., dextrin, cyclodextrin or the like), or sugar alcohol (e.g., xylitol, sorbitol, such as erythritol) preferably in. The natural flavor (e.g., TAU staining, such as Stevia extract) on said flavor number number number (e.g., saccharin, aspartame or the like) can be using synthetic flavor.

Said health nutraceutical compositions in addition to various nutritional number, vitamin, electrolyte, flavor number, colored number, [pheyk the [thu it buys and salts thereof, alginic acid and salts thereof, organic acid, protective colloidal thickening number, pH control number, stabilizing number, antiseptic number, glycerin, alcohol, further number of calcium hydroxide can be used containing carbonated beverages. The triazines of the present invention the amounts of ingredients added to said large but not significant health nutraceutical compositions 100 parts by weight, 0. 01 To 0. 1 Parts by weight of generally is selected from the range are disclosed.

Hereinafter, the present invention broadcast receiver using more detailed in the embodiment. In the embodiment of the present invention is more specifically describe the present invention only these for the number one is a person with skill in the art that these range by not notified to the reduced in the art are disclosed.

In the embodiment 1. Nine seconds dihydroxyflavanone Extract and Dihydroxyflavanone Extract (Comparison example) Number of bath

The jaws of the present invention dihydroxyflavanone number nine seconds, after 20 minutes to heat from the shell hole number information for a stand-alone heat dihydroxyflavanone clothing, a number was nine seconds dihydroxyflavanone are marked on the high pressure liquid coolant at room temperature. A number nine seconds 15 l (v/v) 70% ethanol for 1 kg of applying high pressure liquid coolant dihydroxyflavanone, 85 °C 3 is then in time, reducing pressure in the concentrated liquid filtering 45 °C, drying the extract 119 dihydroxyflavanone nine seconds. 2 G obtained a.

On the other hand, comparison embodiment to use the shell number information for 1 kg dihydroxyflavanone extract number jaws to 70% (v/v) ethanol 15 l dihydroxyflavanone hole heat alone without further, 85 °C 3 is then in time, reducing pressure in the concentrated liquid filtering 45 °C, drying dihydroxyflavanone extract 119. 4 G obtained a.

In the embodiment 2. Nine seconds dihydroxyflavanone and Dihydroxyflavanone It is sour with the mote but oh extract number comparison inhibitory activity

It is sour with the mote but oh extract of the present invention comparing the number nine seconds and it is sour with the mote but oh dihydroxyflavanone extract dihydroxyflavanone number inhibitory activity was inhibitory activity. It is sour with the mote but oh number activity of 50 mm potassium phosphorylation buffer (potassium phosphate buffer, pH 6. 8) 2 Mm L - tyrosine (L-a tyrosine) in a matrix of the liquid 176 to 20 micro l micro l melting, it is sour with the mote but oh nine seconds in the embodiment 1 and 2 200 U/Ml (it is sour with the mote but oh number) number of micro l dihydroxyflavanone of extract (6. 25, 12. 5, 25, 50 And 100 micro g/Ml) or dihydroxyflavanone (6. 25, 12. 5, 25, 50 And 100 micro g/Ml) 2 in 30 minutes 37 °C reacting 450 nm were measured in micro l extract solution.

As a result, the disclosure also 1 and table 1 as shown but it is sour with the mote but oh number nine seconds extract and both inhibitory activity dihydroxyflavanone dihydroxyflavanone extract, extract of the present invention significantly excellent inhibitory activity as compared to nine seconds dihydroxyflavanone dihydroxyflavanone extract that it is sour with the mote but oh number has been confirmed.

In the embodiment 3. Nine seconds dihydroxyflavanone and Dihydroxyflavanone L - extractDOPA Inhibitory activity comparison

L a-DOPA inhibitory activity of the present invention extract dihydroxyflavanone nine seconds and comparing dihydroxyflavanone extract was L-a DOPA inhibitory activity. L a-DOPA activity α-a MSH (melanocyte non-stimulating hormone) induce the biosynthesis of melanin after processing, 50 mm of potassium phosphorylation buffer (potassium phosphate buffer, pH 6. 8) 2 Mm L-a DOPA (L-a 3, 4 a-dihydroxypheny provided lalanine) a micro l 176 to 20 micro l melts in a matrix of the liquid, it is sour with the mote but oh nine seconds in the embodiment 1 and 2 200 U/Ml (it is sour with the mote but oh number) number of micro l dihydroxyflavanone of extract (50, 100 and 200 micro g/Ml) or dihydroxyflavanone (50, 100 and 200 micro g/Ml) 2 in 30 minutes 37 °C reacting 450 nm were measured in micro l extract solution.

As a result, the disclosure also 2 and table 2 as nine seconds extract and L-a DOPA inhibitory activity is shown but both dihydroxyflavanone dihydroxyflavanone extract, extract of the present invention L a-DOPA inhibitory activity as compared to nine seconds dihydroxyflavanone dihydroxyflavanone extract that significantly excellent has been confirmed.