난용성 약물 전달용 용해성 마이크로니들
The Korean patent application number 10 - 2015 - 0048454 6 April 2015 application is the application call, the Korean patent application number 10 - 2015 - 0151027 29 October 2015 application call, the Korean patent application number 10 - 2015 - 0048482 6 April 2015 application call, the call priority based on Korean patent application number 10 - 2015 - 0151046 and 29 October 2015 application and termination resistance, specification and drawing application corresponding to the application disclosure of all contents to aided with each other. The present invention refers to soluble microneedle, sparingly soluble compound dermal administration of a method using the same, and to a method for tank number said soluble microneedle are disclosed. Isoflavones antioxidant, antimicrobial, anticancer, osteoporosis billion number, a reduction in blood cholesterol regulation of fat metabolism in an excellent effect when it is judged that known. In addition anti-hardenable efficacy for improving skin aging skin isoflavones also reported for use in forward more progressing disclosed. However isoflavones water sparingly soluble substance, oil, ethanol or the like volcanic ash well and beverage, food, cosmetic, cosmetic number article number number pin is effective concentration difficult under anger drainage holes. The method for improving this point the gun [cep anger () acidification of isoflavone to isoflavone cyclodextrin patent disclosure number 1997 - 309902 method call number was not in Japan. However cyclodextrin to perfume component significantly enhanced solubility even when it is used isoflavones expression may be discarded without antiseptic number fragrance with door number point etc. bonded antiseptic activity. On the other hand, in Japanese patent disclosure number 2001 - 0006678 disclosure to the propylene glycol to form a number of solubilized cosmetic efficacy using technologies that fully exhibited under anger number number even in a concentration of enough for to tame. Number varnish resin (Genistein) or die set number [phul regular course including isocyanate such as like in (Daidzein), sparingly soluble physiologically active components in water or oil and substantially of volcanic ash, the deep with it will bloom, [leyn the glycol relatively enhances dissolution, such as not to be separated easily dissolved when used solvent precipitation -8 pin part is disclosed. Traditionally used in green onion five glows eastern medical In order to improve time on said door number such as sparingly soluble physiologically active components in Microparticle Liposome number by inclusion in or added to the films, increasing effort is attempted content which, liposome or nanosphere () stability to the gun [cep anger, etc. transdermal permeation efficiency and and preparation effort is attempted ( The solubility in water of 1 mg/ml hereinafter in the present invention includes the number and if pH7 25 °C, sparingly soluble physiologically active component, in particular a phenol compound soluble micro needle stably impregnated with a sparingly soluble, sparingly soluble via the skin consists of delivering a number bath method and system, the system using a number skin sparingly soluble component administering method are disclosed. In order to solve said a number and, in the present invention refers to pH7, 25 °C solubility in water of 1 mg/ml hereinafter, sparingly soluble compounds containing a number microneedle including micro particles and, more preferably, said microneedle material forming skin dissolved in microneedle or microneedle collapse upon application skin microneedle dissolved rapidly into the skin and micro particles contained within the emerging, solubility in water of 1 mg/ml hereinafter pH7, 25 °C micro particles contained therein from sparingly soluble compounds in to emit therefrom. Solubility in water of the present invention is 1 mg/ml hereinafter sparingly soluble the circular pH7, 25 °C, preferably 0. 5 Mg/ml hereinafter big melt viscosity of 0.1. As well as said water, said solubility in polar solvent (such as ethanol) is in the range including meaning be also are disclosed. Said water-soluble compound is sparingly soluble phenol compound and/or comprising sparingly soluble isoflavone can be. The present invention can be included in the water-soluble compound is sparingly soluble phenol compound can be, for example, in green onion five glows (paeonol), cleaning sofa glow (chrysophanol), mycophenolic acid (mycophenolic acid), tetra ethyl (tetrabutyl ethylidenebisphenol), or derivatives can be selected from one or more of, preferably in green onion five glows or its derivatives can be. The present invention can be included in the water-soluble compound is sparingly soluble isoflavone can be, e.g., it is a writing hour reel (glycitein), (cucurbitacins), it is big expense it burnt (curbitacin), franc (Prangenidin), number varnish resin (genistein), die set (daidzein) or mixtures thereof can be in number. The present invention also referred to when the various parties study a variety a sparingly soluble compound administration system said various aspects of the door at a point number is easy to not. The present invention various parties within the skin (soluble) end effort produced by impregnating a sparingly soluble compound soluble in micro particles including microneedle sparingly soluble compound capable of delivering his invention surprising that effectively into the skin. Sparingly soluble component is impregnated with a soluble microneedle to side sealed micro particles applied to the skin, the skin micro-needle into the skin while dissolving by water in the sparingly soluble substance is sealed in micro particles transferred. Skin and be transferred into micro particles can be transferred into the sparingly soluble component effectively treated by release from skin. Micro particles delivered to skin such as a wrinkle improvement effectively skin poorly soluble component is partially overlap can exhibit. In order to achieve a number as above and, microneedle device must be soluble in the cosmetic composition, in order to form a nick it buys in egg base soluble microneedle (Hyaluronic acid), sodium - carboxymethylcellulose (Na-a CMC, Sodium carboxymethyl cellulose), vinylpyrrolidone - vinyl acetate copolymer, polyvinyl alcohol (Poly vinyl alcohol), and water-soluble polymer such as polyvinyl pyrrolidone (Poly vinyl pyrrolidone); system of xylose (Xylose), sucrose (Sucrose), maltose (Maltose), lactose (Lactose), such as trehalose (Trehalose) saccharide; or mixtures thereof can be used. In particular, microneedle skin permeation strength, such as the dissolution rate in considered comprehensive skin nick it buys in egg base (Oligo provided Hyaluronic acid), sodium - carboxymethylcellulose (Na-a CMC, Sodium carboxymethyl cellulose), and saccharide (saccharide) (more preferably, trehalose (Trehalose)) more preferably a mixture of, glycerin (Glycerine) mixed with up to carry a further preferably. Preferably, the present invention according to the microneedle sparingly soluble compounds mentioned component forming said microcapsule containing particles and microneedle plasticizer addition number, number surfactants, preserving number, such as steroidal anti-inflammatory can additionally contains number. Said plasticizer number (plasticizer) include, e.g., ethylene glycol (Ethylene glycol), propylene glycol (Propylene glycol), dipropylene glycol (Dipropylene glycol), butylene glycol (Butylene glycol), glycerin (Glycerine) such as polyol can be used in combination or alone. In the present invention, said material forming a sparingly soluble phenol compound with micro particles in the microneedle number tank should be stably to sparingly soluble phenol compound and does not deposit the gun it will come in contact. Such micro particles include hydrophobic core material forming polymer form can be used, such polymer include poly (lock taken), poly (icrospheres), poly (lock taken - nose - icrospheres), polyanhydride, polyorganosilsesquioxane , polyether ester, polycaprolactone, polycaprolactone (MPEG-a PCL) - methoxy polyethylene glycol mono -, polyester-amide, poly (view mote metallic acid), poly (ballet metallic acid), polyurethane, or the copolymers are biodegradable polymer; and polyacrylate, ethylene - vinyl acetate polymer, acrylic substituted cellulose acetate, non - degradable polyurethane, polystyrene, polyvinyl chloride, polyvinyl films a supported window, poly (vinyl imidazole), chloro sulfonate polyolefin (chlorosulphonate polyolefins), biodegradable polymer fibers such as polyethylene oxide or their copolymer - alone or it can be used in combination, limited to the present invention refers to are not correct. Method of preparing inclusion and skin in poorly when considered collectively like release, said polymer include poly (lock taken), poly (icrospheres), and one or more methoxy polyethylene glycol mono - poly (lock taken - nose - icrospheres) - polycaprolactone (MPEG-a PCL) and more preferably a mixture of. The specification used in ' sparingly soluble compound sealed micro particles' referred to as micro particles it sparingly soluble compounds which are located inside the graphics state, by completely enclosing the sparingly soluble compound is segmented state big particles. The same meaning in terms used in specification enclosure designs that specification can be used in the inclusion absolutely free. 'Impregnated' by state and have the meanings referred to as included, microneedle is located inside external environment completely blocked condition as well as, micro particles exposed on a surface of a portion of the microneedle can be also includes state. 'microneedle impregnated with' was the meanings, as well as if fully enclosed within the microneedle, when the microneedle to the skin of microneedle and micro particles can be administered together with the microneedle can be understood to form the general outline all included two apparently incompatible. The purpose of the invention which may achieve such micro particles may be type matrix (matrix), leisure bore (reservoir) disapproval bill type. The present invention can be used in the present invention micro wafer is provided into various sacrificial 1308. number bath method. For example, solvent exchange method (Solvent exchange method), evaporation of the solvent method (Solvent evaporation method), membrane permeate method (Membrane dialysis method), by spray drying (Spray drying method) can be used in the present invention high pressure liquid coolant to one number can be micro particles. For example, document Preferably, the present invention according to the diameter of the micro particles 0. 01 To 10 micro m may have a. The particle size greater than 10 micro m microneedle needle fixed transmission strength of weak when impregnated with skin can be difficult. The present invention according to the diameter of the laser light scattering (LLS) method micro particles may be measured by, e.g., Malvern Zetasizer 2000 yarnTM For measuring with each other. Preferably, based on the total weight of a phenol compound of the present invention micro wafer is sparingly soluble micro particle contrast 0. 01 To 20% by weight which contains, more preferably 0. 1 To 10% by weight can be containing. In addition, the microneedle of the present invention such micro microneedle particles based on the total weight contrast 0. 05 To 10% by weight is preferably containing, more preferably 0. 1 To 5% by weight may contain disclosed. The embrittlement microneedle within said content value, may have excellent skin transmittance. The sparingly soluble substance can be used in the present invention include in green onion five glows (paeonol), cleaning sofa glow (chrysophanol), mycophenolic acid (mycophenolic acid), tetra ethyl (tetrabutyl ethylidenebisphenol), or derivatives can be selected from one or more. It is a writing hour reel (glycitein) through another in the embodiment, (cucurbitacins), it is big expense it burnt (curbitacin), franc (Prangenidin), varnish resin (genistein) number, number die set of the present invention can be used in (daidzein) sparingly soluble substance or a mixture of these. In addition, the present invention refers to micro-needle is sparingly soluble phenol compound administration as above are attached to the microneedle patch (patch) system (delivery) number substrate. In the embodiment of the present invention is preferably a therapeutic dermal administration method number poorly soluble compounds in cosmetic substrate. The present invention refers to in addition to the aforementioned sparingly soluble phenol compound (S1) polymer containing micro particles using a number within the skin (S2) and utilized in a bath containing a bath soluble micro particles said microneedle number including the step, so that the inclusion is sparingly soluble phenol compound, to effectively transferred into the skin, exhibiting excellent effect sparingly soluble substance containing a bath method number number microneedle substrate. The present invention refers to in addition the present invention according to use sparingly soluble phenol microneedle characterized by a number of effective delivery method dermal administration achieve skin substrate. Preferably said dermal administration method is a cosmetic essence therapeutic dermal administration method number substrate. In the embodiment of the present invention using 1 mg/ml hereinafter is sparingly soluble in water in the present invention refers to said one microneedle pH7, 25 °C solubility in stably impregnated with a phenol compound, a phenol compound is sparingly soluble in 1 mg/ml hereinafter pH7, 25 °C solubility in water into the skin effect for delivering a number method dermal administration of sparingly soluble phenol compound can be. The present invention refers to sparingly soluble compound be stably the gun it will come in contact. The present invention refers to sparingly soluble compound can be effectively transferred to the skin. The present invention refers to skin sparingly soluble compound stably inclusion is effectively transferred excellent skin wrinkle reduction effect can be obtained by a number microneedle substrate. The present invention refers to the use of the microneedle characterized a sparingly soluble substance dermal administration of a method number substrate. The specification of the present invention preferred embodiment example in which a are added in the following drawing, further understanding of the invention the video and feature of the present invention which serves the aforementioned three, are not described in the present invention refers to such drawing like a is confined only to the interpreted. Figure 1 shows a method of the present invention according to a various number tank 06 one example a microneedle surface also are disclosed. In the solution casting method can be soluble microneedle number tank, vacuum and/or centrifuge casting solution to a mold to mold filling high pressure liquid coolant liquid to solid after drying can be fine to number. The microneedle structure is provided to convert synthesis and natural water-soluble polymer material can be used. Figure 2 the present invention according to a sparingly soluble compound for assessing the behavior of release of microneedle included in a Franz diffusion cell by a goniophotometer. Figure 3 equipped with porcine skin using Franz diffusion cell, in porcine skin and acceptor solution containing cream (P-a Cream), in green onion five glows in green onion five glows and Microparticle solution impregnated Microneedle (P-a S MN) (P-a MP MN) by presenting a total content from impregnated Microneedle skin permeation is shown graph are disclosed. Figure 4 porcine skin using Franz diffusion cell mounted on the rating, in green onion five glows in green onion five glows in green onion five glows from solution containing micro particles or micro-needle release evaluation result is shown on the graph are disclosed. Figure 5 shows a cream containing also the present invention according to (P-a Cream), solution impregnated in green onion five glows in green onion five glows and Microparticle Microneedle Microneedle (P-a S Microneedle) (P-a MP Microneedle) wrinkles appearing in a long-used and then impregnated with positive wrinkle eye rim 06 is incubated with a test result are disclosed. Figure 6 porcine skin using Franz diffusion cell mounted on the rating, number from varnish resin or die set number phosphorous emission evaluation result microneedle 06 a graph are disclosed. Figure 7 shows a varnish resin varnish resin solution impregnated Microneedle number and also the present invention according to number (G provided S Microneedle) impregnated Microneeedle Microparticle wrinkles appearing in a long-used and then positive wrinkle eye rim (G-a MP Microneedle) 06 is incubated with a test result are disclosed. Hereinafter, in the embodiment example of the present invention to aid in understanding like detailed the on-sensors other. However, the present invention according to in the embodiment are various other shape can be, in the embodiment of the present invention are interpreted to range limited to don't substrate. With the present invention mean knowledge of the present invention in the embodiment are the art to entire surface account for which ball number are disclosed. The specification referred to responsible for content in a special free weight % respectively. In green onion five glowsMicro particles Including Microneedle Number bath <In green onion five glows cream number bath> Such as for table 1, 0 in green onion five glows. 05% Oil-in-water emulsion (oil in water) containing his number number type high pressure liquid coolant. <In green onion five glows micro particle number bath>Methoxy poly (ethylene glycol) - b - poly (caprolactone) (methoxy poly (ethyleneglycol) - b-a poly (caprolactone), mPEG-a PCL) double block copolymer using a sparingly soluble substance in green onion five glows-gate (Paeonol) collection. First, mPEG-a PCL (5k - 5k, mixed 5k - 10k 1:1) 40 ml ethanol solution of a reel [lik [lik tree writing scherrer id 20g/capric acid capric acid in green onion five glows to 2g 10g melting solution is mixed and melting. 0. 60 Ml 5% Polyvinyl alcohol aqueous solution to said solution was added gradually with stirring. After left for evaporating a solvent ethanol varied with stirring, using a stand-alone residual ethanol by rotary evaporator number, number was 2% or more in green onion five glows content solution to high pressure liquid coolant. A stand-alone solution prepared by the number number been precipitated by filtering. Liquid chromatography to analysis result, 2% content has been identified, Particle size analyzer (Malvern Zetasizer 2000TM ) Min 210 nm average grain size of the micro particles to analysis results. <In green onion five glows in green onion five glows or micro particles containing microneedle number bath> Such as for table 2, microneedle (P-a S MN) or in green onion five glows in green onion five glows (solution be added form) containing micro particles containing micro-needle (P-a MP MN) number was a high pressure liquid coolant. Specifically impregnated soluble (soluble) microneedle (P-a S MN) number as follows his high pressure liquid coolant. Oligo-a HA (Hyaluronic acid), Na-a CMC (Sodium carboxymethyl cellulose) and Trehalose number number after deformation by dissolving Glycerin, HCO-a 40 - TG in green onion five glows (reel [lik [lik tree writing scherrer id capric acid/capric acid) solution was added to solution number and high pressure liquid coolant. High pressure liquid coolant to a silicon microneedle mold after casting in green onion five glows solution number, 10 minutes centrifugation 3000 rpm in fine liquid-gate mold filling. Solution after filling drying ovens (70 °C) 3 in drying time, adhesive film using a microneedle has been separated from the silicone mold. Specifically in green onion five glows micro particles impregnated soluble (soluble) microneedle (P-a MP MN) number as follows his high pressure liquid coolant. Oligo-a HA (Hyaluronic acid), Na-a CMC (Sodium carboxymethyl cellulose) and Trehalose number number after deformation by dissolving Glycerin, micro particles by the addition of a high pressure liquid coolant solution (2% in green onion five glows) HCO-a 40 in green onion five glows and his number. Number silicone microneedle mold after casting solution to high pressure liquid coolant, 3000 rpm 10 minutes centrifugation in fine liquid-gate mold filling. Solution after filling drying ovens (70 °C) 3 in drying time, adhesive film using a microneedle has been separated from the silicone mold. <In green onion five glows emission behavior> Porcine skin in a Franz diffusion cell mounted by employing high pressure liquid coolant in green onion five glows from release number microneedle cream was assessed (also reference 2). DPG of PBS solution containing 30% by weight aqueous solution it (acceptor solution) was used. I.e., using Franz diffusion cell, tissue and acceptor solution were measured using Liquid Chromatography content in green onion five glows of pork blood according to time. The pork blood in green onion five glows cream bar or, in green onion five glows in green onion five glows or micro particles impregnated microneedle is attached has been confirmed that the overall content in green onion five glows transmitted into the skin over time. Also shown to result 3. As appearing also 3, including about 10 micro g cream skin which is transmitted through the sample but, in green onion five glows in green onion five glows and transmitted directly to the skin by way of micro wafer is then impregnated Microneedle Needle g or more and not more than about 5, 6 respectively high skin permeation cream contrast micro-transmitting 50, 60 shown. In addition, the conventional high skin permeation when two microneedle pork blood part penetrates into the skin in order to identify the aspects unit, in green onion five glows in green onion five glows or micro particles impregnated within the skin to form a microneedle device for microneedle the Pig to rust after a number (attached time: 2 time, temperature: 32 °C) microneedle been stand-alone. By franz diffusion cell placed in a microneedle swine skin absorption, Pig over time are released into an behavior in skin Acceptor solution has been confirmed. Also shown to result 4. Also 4 as appearing, in green onion five glows solution impregnated Microneedle by swine skin over time and decrease smoothly in porcine skin penetration in green onion five glows content, content of a sputtering process while also Acceptor solution in green onion five glows, microparticle impregnated Microneedle impregnated in green onion five glows in green onion five glows by the pork blood within the skin in this case reduced, abruptly increases even by Acceptor solution has been confirmed. This solution in the case of impregnated Microneedle in green onion five glows with the presence of precipitated in crystalline form, not being available for absorption and cosmetic composition because, while the amorphous state if released in green onion five glows Microparticle Microneedle Microparticle impregnated in the transflective liquid skin are disclosed. <Improving> In green onion five glows cream, solution impregnated Microneedle in green onion five glows in green onion five glows and Microparticle Microneeedle impregnated with a pleat peaks (P-a S Microneedle) (P-a MP Microneedle) eye rim 12 degree wrinkle daytime daily after processing was assessed. Wrinkle (silicone replica) through Image analysis method has been confirmed that the degree silicon simulation plate and corrugated (N=20). 5 Result is also shown. The present invention according to cream in green onion five glows, solution impregnated in green onion five glows in green onion five glows as compared to 3 times each impregnated Microneedle Microneedle Microparticle, 2 times bix excellent effect, this is a sparingly soluble drug penetrates into the skin by way of the Microparticle Microneedle are discharged from, taste has been confirmed that the adhesion tape. Number varnish resinMicro particles Including Microneedle Number bath <Number varnish resin micro particle number bath> Methoxy poly (ethylene glycol) - b - poly (caprolactone) (methoxy poly (ethyleneglycol) - b-a poly (caprolactone), mPEG-a PCL) double block copolymer using a sparingly soluble substance for capturing number varnish resin (Genistien)-gate. First, mPEG-a PCL (5k - 5k, mixed 5k - 10k 1:1) 40 ml of ethanol solution to a number varnish resin melts 2g PEG400 20g 10g melting solution and mixed. 0. 5% Polyvinyl alcohol 100 ml aqueous solution to said solution was added gradually with stirring. After left for evaporating a solvent ethanol varied with stirring, using a stand-alone residual ethanol by rotary evaporator number, number varnish resin content was 2% solution number so that high pressure liquid coolant. Filtering a stand-alone solution prepared by the number number number been precipitated by fusing the varnish. Liquid chromatography to analysis results, varnish lymphocytes to content number 1. 9% Has been identified, Particle size analyzer (Malvern Zetasizer 2000)TM 150 Nm min average grain size of the micro particles to analysis results. <Number varnish resin varnish resin containing micro particles or number number microneedle bath> Such as for table 3, number number varnish resin varnish resin (solution be added form) or micro particles containing micro-needle number was a high pressure liquid coolant. Specifically number varnish resin impregnated with a soluble (soluble) number (G provided S MN) microneedle as follows his high pressure liquid coolant. Oligo-a HA (Hyaluronic acid), Na-a CMC (Sodium carboxymethyl cellulose) and Trehalose number number after deformation by dissolving Glycerin, HCO-a 40 - DPG solution by the addition of a high pressure liquid coolant and number varnish resin solution was number. High pressure liquid coolant to a silicon microneedle mold after casting number number varnish resin solution, 10 minutes centrifugation 3000 rpm in fine liquid-gate mold filling. Solution after filling drying ovens (70 °C) 3 in drying time, adhesive film using a microneedle has been separated from the silicone mold. Specifically number varnish resin micro particles (G-a MP MN) impregnated with a soluble (soluble) microneedle number as follows his high pressure liquid coolant. Oligo-a HA (Hyaluronic acid), Na-a CMC (Sodium carboxymethyl cellulose) and Trehalose number number after deformation by dissolving Glycerin, HCO-a 40 micro particles by the addition of a solution (2% varnish resin number) number and number varnish resin was high pressure liquid coolant. Number silicone microneedle mold after casting solution to high pressure liquid coolant, 3000 rpm 10 minutes centrifugation in fine liquid-gate mold filling. Solution after filling drying ovens (70 °C) 3 in drying time, adhesive film using a microneedle has been separated from the silicone mold. <Number varnish resin emission behavior> Franz diffusion cell number in porcine skin mounted by employing high pressure liquid coolant from varnish resin micro-needle release number was assessed (also reference 2). DPG of PBS solution containing 30% by weight aqueous solution it (acceptor solution) was used. I.e., using Franz diffusion cell, pork blood and tissue in the number of acceptor solution according to time were measured using Liquid Chromatography varnish resin content. The number varnish resin varnish resin micro particles impregnated microneedle pork blood or number attached thereto within the skin to form a microneedle the Pig to rust after a number (attached time: 2 time, temperature: 32 °C) microneedle been stand-alone. Microneedle franz diffusion cell number by swine skin absorption and carries varnish to be driven with a, number are released into an Acceptor solution has been confirmed that the behavior over time varnish and carries Pig in skin. 6 Also shown to result. 6 Also as appearing, Genistein solution impregnated Microneedle Genistein infiltrated porcine skin over time by porcine skin Genistein content the packet, while substantially not detected Acceptor solution of Genistein content, Genistein microparticle impregnated Microneedle Genistein infiltrated pork blood by the porcine skin Genistein content and decrease smoothly, even a secondary coil by Acceptor solution has been confirmed. This, in the case of impregnated with at least one residing Genistein Microneedle Genistein solution precipitated in crystalline form, cosmetic composition Genistein not being available for absorption and because, while if in the amorphous state is released into the Microparticle Microneedle Genistein Microparticle impregnated by Genistein's oldest. <Improving> Genistein solution impregnated Microneedle Genistein Microparticle Microneeedle impregnated with a pleat peaks (G provided S Microneedle) and daytime daily after processing degree wrinkle eye rim 12 (G-a MP Microneedle) was assessed. Wrinkle and wrinkle Image analysis method has been confirmed through the silicon simulation plate (silicone replica) degree (N=20). 7 Also have shown to result. The present invention according to Genistein solution impregnated Microneedle Genistein Microparticle 3 times relative to excellent effect in impregnated Microneeedle bix, this is penetrated into the skin by way of a sparingly soluble drug by Microparticle Genistein Microneedle emitted from, taste has been confirmed that the adhesion tape. The present invention refers to a cosmetically treating a skin wrinkle, can be used as pharmaceutical uses. The microneedle of the present invention excellent skin wrinkle reduction effect can be expected. The present invention relates to a system for administering a poorly-soluble compound to the skin, the system being capable of exerting an excellent effect by stably impregnating the poorly-soluble compound and effectively delivering the poorly-soluble compound into the skin, and the present invention is technically characterized by a microneedle to which microparticles comprising a poorly-soluble compound are added. In addition, the present invention provides a method for administering a poorly-soluble compound to the skin, the method being characterized by using the microneedle. Sparingly soluble compounds containing micro particles including microneedle. According to Claim 1, characterized in that the sparingly soluble compounds are sparingly soluble phenol compound or sparingly soluble isocyanate [phul person oneself said microneedle. According to Claim 1, said solubility in water of 1 mg/ml hereinafter pH7, 25 °C sparingly soluble compounds are characterized in a microneedle. According to Claim 2, said sparingly soluble phenol compound is in green onion five glows (paeonol), cleaning sofa glow (chrysophanol), mycophenolic acid (mycophenolic acid), tetra ethyl (tetrabutyl ethylidenebisphenol), or derivatives characterized selected from least one microneedle. According to Claim 4, characterized in that the sparingly soluble phenol compound or a derivative thereof in green onion five glows a microneedle. According to Claim 2, said it is a writing hour reel sparingly soluble isoflavones (glycitein), (cucurbitacins), it is big expense it burnt (curbitacin), franc (Prangenidin), number (genistein) varnish resin, or a mixture of these die set number (daidzein) characterized in a microneedle. According to Claim 6, said it is a writing hour reel sparingly soluble isoflavones (glycitein), number (genistein) varnish resin, or a mixture of these die set number (daidzein) characterized in a microneedle. According to Claim 1, in mouth and skin material forming said microneedle, said micro wafer is hydrophobic core characterized tloop form in the event that the microneedle. According to Claim 8, said nick it buys in egg base material forming the microneedle (Hyaluronic acid), sodium - carboxymethylcellulose (Na-a CMC, Sodium carboxymethyl cellulose), vinylpyrrolidone - vinyl acetate copolymer, polyvinyl alcohol (Poly vinyl alcohol), polyvinyl pyrrolidone (Poly vinyl pyrrolidone), saccharide or mixtures thereof characterized by a microneedle. According to Claim 8, said microneedle (plasticizer) in addition to the plasticizer material forming the microneedle number characterized in further including a microneedle. According to Claim 8, said hydrophobic core forming polymer poly (lock taken), poly (icrospheres), poly (lock taken - nose - icrospheres), polyanhydride, polyorganosilsesquioxane , polyether ester, polycaprolactone, polycaprolactone (MPEG-a PCL) - methoxy polyethylene glycol mono -, polyester-amide, poly (view mote metallic acid), poly (ballet metallic acid), polyurethane, polyacrylate, ethylene - vinyl acetate polymer, acrylic substituted cellulose acetate, non - degradable polyurethane, polystyrene, polyvinyl chloride, polyvinyl films a supported window, poly (vinyl imidazole), chloro sulfonate polyolefin (chlorosulphonate polyolefins), polyethylene oxide, or copolymer, or a mixture of these characterized a microneedle. According to Claim 8, said hydrophobic core forming polymer poly (lock taken), poly (icrospheres), with at least one of mono - and poly (lock taken icrospheres - nose -) methoxy polyethylene glycol - polycaprolactone (MPEG-a PCL) either a mixture of microneedle characterized. According to Claim 1, characterized in that said micro wafer is then matrix type or leisure bore type a microneedle. According to Claim 1, said micro particle has a diameter of 0. 01 To 10 μm characterized in the microneedle. (S1) hydrophobic core forming polymer liquid containing micro particles in the sparingly soluble compound number tank; and (S2) be utilized in micro particles within the skin containing a bath soluble said microneedle including the step number, sparingly soluble compound containing microneedle number bath method. According to Claim 15, said solubility in water of 1 mg/ml hereinafter pH7, 25 °C sparingly soluble compounds are characterized in a microneedle manufacturing method. According to Claim 15, said water-soluble compound is sparingly soluble phenol compound and, said sparingly soluble phenol compound is in green onion five glows (paeonol), cleaning sofa glow (chrysophanol), mycophenolic acid (mycophenolic acid), tetra ethyl (tetrabutyl ethylidenebisphenol), or derivatives selected from least one manufacturing method characterized microneedle. According to Claim 15, said water-soluble compound is sparingly soluble isoflavone and, said it is a writing hour reel sparingly soluble isoflavones (glycitein), (cucurbitacins), it is big expense it burnt (curbitacin), franc (Prangenidin), number varnish resin (genistein), die set number in a microneedle manufacturing method characterized (daidzein) or a mixture of these. In accordance with any one of Claims 1 to Claim 14 using 1 mg/ml hereinafter sparingly soluble compound solubility in water of microneedle pH7, 25 °C in characterized by delivering into the skin to improve the skin wrinkle, method dermal administration of a poorly water soluble compound. Component Paeonol cream (% by weight) C14 provided 22 alcohol, C12 provided 20 alkyl writing base nose side (C14 provided 22 alcohol mixture: C12 provided 20 alkyl writing base nose side weight ratio=80:20) 1. 5 Writing three reel [su reel oh [ley [thu 1. 2 Not pin -100 stearate 0. 9 Three reels biting alcohol 1. 5 Poly-methyl-glyceryl -3 writing base course d [su reel oh [ley [thu 1. 5 The [tu pulley it counted number four mote hydrogel 4. 5 Cycle process siloxane 3. 5 Carbomer 0. 2 Tromethamine 0. 2 Glycerin 3 Deep with it will bloom, [leyn the writing this call 3 1, 2 - Hexanediol 2 In green onion five glows reel [lik [lik tree writing scherrer id solution (5%) - capric acid/capric acid 1 Be positive number To 100 (% By weight) P-a S MN (% By weight) P-a MP MN Oligo-a HA 6 6 Na-a CMC 6 6 Trehalose 10 10 Glycerin 5 5 HCO-a 40 0. 2 0. 2 (5%) Paeonol provided TG solution 1. 0 - Paeonol microparticle (2%) - 2. 5 Water To 100 To 100 (Weight %) G-a S MN (Weight %) G-a MP MN Oligo-a HA 6 6 Na-a CMC 6 6 Trehalose 10 10 Glycerin 5 5 HCO-a 40 0. 2 0. 2 (5%) Genistein-a DPG solution 1. 0 - Genisteinmicroparticle (2%) - 2. 5 Water To 100 To 100
