Bispecific antibody constructs for CDH3 and CD3

CPC - классификация

AA6A61A61KA61K2A61K20A61K203A61K2039A61K2039/A61K2039/5A61K2039/50A61K2039/505A61PA61P3A61P35A61P35/A61P35/0A61P35/00A61P35/02CC0C07C07KC07K1C07K16C07K16/C07K16/2C07K16/28C07K16/280C07K16/2809C07K16/3C07K16/30C07K16/305C07K16/3053C07K2C07K23C07K231C07K2317C07K2317/C07K2317/3C07K2317/31C07K2317/33C07K2317/5C07K2317/56C07K2317/565C07K2317/6C07K2317/62C07K2317/622C07K2317/7C07K2317/73C07K2317/732C07K2317/9C07K2317/92C07K2317/94

IPC - классификация

AA6A61A61KA61K3A61K39A61K39/A61K39/0A61K39/00A61PA61P3A61P31A61P31/A61P31/0A61P31/04A61P35A61P35/A61P35/0A61P35/00A61P35/02CC0C07C07KC07K1C07K16C07K16/C07K16/0C07K16/00C07K16/2C07K16/28C07K16/3C07K16/30

Цитирование НПИ

Ahmed et al., HER2-directed therapy: current treatment options for HER2-positive breast cancer, Breast Cancer, 22:101-16 (2015).
Altschul et al., Basic local alignment search tool, J. Mol. Biol., 215:403-10 (1990).
Altschul et al., Gapped BLAST and PSI-BLAST: a new generation of protein database search programs, Nucleic Acids Res., 25:3389-402 (1997).
Altschul et al., Local alignment statistics, Methods in Enzymology, 266:460-80 (1996).
Aplin et al., Preparation, properties, and applications of carbohydrate conjugates of proteins and lipids, CRC Crit. Rev. Biochem., 259-306 (1981).
Arakawa et al., Protein—Solvent interactions in pharmaceutical formulations, Pharm Res. 8(3): 285-91 (1991).
Artsaenko et al., Expression of a single-chain Fv antibody against abscisic acid creates a wilty phenotype in transgenic tobacco, The Plant J, 8: 745-50 (1995).
Baek et al., CDH3/P-Cadherin regulates migration of HuCCT1 cholangiocarcinoma cells, Anat Cell Biol., 43:110-7 (2010).
Bruhl et al., Depletion of CCR5-expressing cells with bispecific antibodies and chemokine toxins: a new strategy in the treatment of chronic inflammatory diseases and HIV, Immunol., 166:2420-6 (2001).
Caaveiro et al., 4ZMT Crystal structure of human P-cadherin (ss-X-dimer-long), Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB) (priority date Apr. 17, 2015; filed Apr. 18, 2016).
Carter et al., High level Escherichia coli expression and production of a bivalent humanized antibody fragment, Bio/Technology, 10: 163-7 (1992).
Chalfie et al., Green fluorescent protein as a marker for gene expression, Science, 263:802-5 (1994).
Cheadle et al., Cloning and expression of the variable regions of mouse myeloma protein MOPC315 in E. coli: recovery of active FV fragments, Mol. Immunol., 29: 21-30 (1992).
Cheson et al., Report of an international workshop to standardize response criteria for non-Hodgkin's lymphomas. NCI Sponsored International Working Group., J Clin Oncol., 4:1244 (1999).
Chothia et al., Canonical structures for the hypervariable regions of immunoglobulins, J. Mol. Biol., 196: 901 (1987).
Chothia et al., Conformations of immunoglobulin hypervariable regions, Nature, 342: 877-83 (1989).
Clackson et al., Making antibody fragments using phage display libraries, Nature, 352: 624-8 (1991).
Cole et al., Monoclonal Antibodies and Cancer Therapy, Alan R. Liss, Inc., 77-96 (1985).
Conacci et al., The control of BhB10-1 gene expression in the salivary gland of Bradysia hygida (Diptera, Sciaridae) is disrupted in vivo by a delayed effect of cycloheximide, J Clin Invest, 109:987-91 (2002).
Cook et al., The human immunoglobulin VH repertoire, Immunol. Today, 16(5): 237-42 (1995).
Creighton, Proteins: Structure and Molecular Properties, W. H. Freeman & Co., San Francisco, 79-86 (1983).
Cunningham et al., High-resolution epitope mapping of hGH-receptor interactions by alanine-scanning mutagenesis, Science, 244: 1081-5 (1989).
Dall'Acqua et al., Contribution of domain interface residues to the stability of antibody CH3 domain homodimers, Biochem., 37:9266-73 (1998).
Dasgupta et al., Identification of molecular targets for immunotherapy of patients with head and neck squamous cell carcinoma, Oral Oncology, 42(3): 306-16 (2006).
Devereux et al., A comprehensive set of sequence analysis programs for the VAX, Nucl. Acid Res., 12:387-95 (1984).
Duskin et al., Relationship of the structure and biological activity of the natural homologues of tunicamycin, J. Biol. Chem. 257:3105-9 (1982).
Edge et al., Deglycosylation of glycoproteins by trifluoromethanesulfonic acid, Anal. Biochem., 118:131-7 (1981).
Epstein et al., Biological activity of liposome-encapsulated murine interferon y is mediated by a cell membrane receptor, Proc. Natl. Acad. Sci. USA, 82:3688-92 (1985).
Fanslow et al., Structural characteristics of CD40 ligand that determine biological function, Semin. Immunol., 6:267-78 (1994).
Fecker et al., Expression of single-chain antibody fragments (scFv) specific for beet necrotic yellow vein virus coat protein or 25 kDa protein in Escherichia coli and Nicotiana benthamiana, Plant Mol. Biol., 32: 979-86 (1996).
Feng et al., Progressive sequence alignment as a prerequisite to correct phylogenetic trees, J. Mol. Evol., 35:351-360 (1987).
Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface, Science, 228(4705):1315-17 (1985).
Fishwild et el., High-avidity human IgG kappa monoclonal antibodies from a novel strain of minilocus transgenic mice, Nat Biotechnol., 14(7) :845-51 (1996).
Fotouhi et al., Global hypomethylation and promoter methylation in small intestinal neuroendocrine tumors: an in vivo and in vitro study, Epigenetics, 9:987-97 (2014).
Furukawa et al., Roles of E- and P-cadherin in the human skin, Microscopy Res. Technique, 38(4):343-52 (1997).
Gabizon et al., Pharmacokinetics and tissue distribution of doxorubicin encapsulated in stable liposomes with long circulation times, J. National Cancer Inst., 81(19):1484 (1989).
Gamallo et al., The prognostic significance of P-cadherin in infiltrating ductal breast carcinoma, Modern Pathology, 14:650-4, (2001).
Garbe et al., Vemurafenib, Recent Results Cancer Res., 201:215-25 (2014).
GenBank Accession No. JU321883 , TSA: Macaca mulatta Mamu_510094 mRNA sequence, dated Nov. 4, 2014.
GenBank Accession No. JU473826, TSA: Macaca mulatta Mamu_375471 mRNA sequence, dated Nov. 4, 2014.
GenBank Accession No. JU473827, TSA: Macaca mulatta Mamu_375473 mRNA sequence, dated Nov. 4, 2014.
GenBank Accession No. NM_001792, Homo sapiens cadherin 2 (CDH2), transcript variant 1, mRNA, dated Feb. 26, 2018.
GenBank Accession No. NM_001793, Homo sapiens cadherin 3 (CDH3), transcript variant 1, mRNA, dated Mar. 17, 2018.
GenBank Accession No. NM_001794, Homo sapiens cadherin 4 (CDH4), transcript variant 1, mRNA, dated Feb. 26, 2018.
GenBank Accession No. NM_001795, Homo sapiens cadherin 5 (CDH5), mRNA, dated Feb. 6, 2018.
GenBank Accession No. NM_002354, Homo sapiens epithelial cell adhesion molecule (EPCAM), mRNA, dated Mar. 17, 2018.
GenBank Accession No. NM_004360, Homo sapiens cadherin 1 (CDH1), transcript variant 1, mRNA, dated Feb. 19, 2018.
GenBank Accession No. U55762, Cloning vector pEGFP-N1, complete sequence, enhanced green fluorescent protein (egfp) and neomycin phosphotransferase genes, complete cds, Aug. 22, 2003.
GenBank Accession No. XM_002802511, Macaca mulatta cadherin 5, type 2 (CDHS), mRNA, Jun. 1, 2010.
GenBank Accession No. XM_002802516, Macaca mulatta cadherin-1-like (CDH1), mRNA, dated Jun. 1, 2010.
Graham et al. , Characteristics of a human cell line transformed by DNA from human adenovirus type 5, J. Gen Virol., 36:59-74 (1977).
Green et al., Antigen-specific human monoclonal antibodies from mice engineered with human Ig heavy and light chain YACs, Nature Genetics, 7:13-21 (1994).
Green et al., Regulation of B cell development by variable gene complexity in mice reconstituted with human immunoglobulin yeast artificial chromosomes, J. Exp. Med., 188:483-95 (1998).
Gumbiner, Regulation of cadherin adhesive activity, J. Cell. Biol., 148:399-404 (2000).
Hakimuddin et al., Arch. Biochem. Biophys., 259:52 (1987).
Hardy et al., Aberrant P-cadherin expression is an early event in hyperplastic and dysplastic transformation in the colon, Gut, 50:513-519 (2002).
Hawkins et al., Selection of phage antibodies by binding affinity. Mimicking affinity maturation, J. Mol. Biol., 254, 889-96 (1992).
Heim et al., Engineering green fluorescent protein for improved brightness, longer wavelengths and fluorescence resonance energy transfer, Curr. Biol. 6:178-82 (1996).
Hiatt et al., Production of antibodies in transgenic plants, Nature, 342: 76-8 (1989).
Higgins et al., Fast and sensitive multiple sequence alignments on a microcomputer, CABIOS, 5:151-3 (1989).
Holliger et al., “Diabodies”: Small bivalent and bispecific antibody fragments, Proc. Nat. Acad. Sci. USA, 90(14):6444-8 (1993).
Hoppe et al., A parallel three stranded alpha-helical bundle at the nucleation site of collagen triple-helix formation, FEBS Letters, 344:191 (1994).
Huston et al., Protein engineering of antibody binding sites: recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli, Proc. Natl. Acad. Sci USA, 85:5879-83 (1988).
Hwang et al., Hepatic uptake and degradation of unilamellar sphingomyelin/cholesterol liposomes: a kinetic study, Proc. Natl Acad. Sci. USA, 77:4030-4 (1980).
Ichiki et al., Regulation of the expression of human C epsilon germline transcript. Identification of a novel IL-4 responsive element, J. Immunol. 150:5408-17 (1993).
Imai et al., Identification of a novel tumor-associated antigen, cadherin 3/P-cadherin, as a possible target for immunotherapy of pancreatic, gastric, and colorectal cancers, Clin Cancer Res., 14(20) 6487-95 (2008).
International Preliminary Report on Patentability, PCT/EP2016/058482, dated Oct. 17, 2017.
International Search Report and Written Opinion of the International Searching Authority, European Patent Office, dated Oct. 4, 2016.
Jamal-Hanjani et al., Translational implications of tumor heterogeneity, Clin. Cancer Res., 21:1258-66 (2015).
Jarzab et al., Gene expression profile of papillary thyroid cancer: sources of variability and diagnostic implications, Cancer Res, 65(4):1587-97 (2005).
Jones et al., Replacing the complementarity-determining regions in a human antibody with those from a mouse, Nature, 321: 522-5 (1986).
Karlin et al., Applications and statistics fir multiple high-scoring segments in molecular sequences, Proc. Natl. Acad. Sci. U.S.A., 90:5873-87 (1993).
Kaufman et al., Selection and coamplification of heterologous genes in mammalian cells, Methods Enzymol., 185:537-66 (1990).
Kendrick et al., Physical stabilization of proteins in aqueous solution in: Rational Design of Stable Protein Formulations: Theory and Practice, Carpenter and Manning, eds. Pharmaceutical Biotechnology. 13: 61-84 (2002).
Kim et al., P-cadherin expression in gastric carcinoma: its regulation mechanism and prognostic significance, Human Pathology, 41:877-885 (2010).
Kipriyanov et al., Bispecific tandem diabody for tumor therapy with improved antigen binding and pharmacokinetics, J. Mol. Biol., 293:41-56 (1999).
Knappe et al., Herpesvirus saimiri-transformed macaque T cells are tolerated and do not cause lymphoma after autologous reinfusion, Blood, 95:3256-61 (2000).
Koehler et al., Continuous culture of fused cells secreting antibody of predefined specificity, Nature, 256: 495 (1975).
Kozbor et al., The production of monoclonal antibodies from human lymphocytes, Immunology Today, 4:72-9 (1983).
Kufer et al., A revival of bispecific antibodies, Trends in Biotechnology, 22(5):238-44 (2004).
Kufer et al., Construction and biological activity of a recombinant bispecific single-chain antibody designed for therapy of minimal residual colorectal cancer, Cancer Immunol. Immunother., 45:193-7 (1997).
Landschulz et al., The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins, Science, 240:1759-64 (1988).
Langer et al., Biocompatibility of polymeric delivery systems for macromolecules, J. Biomed. Mater. Res., 15:267-77 (1981).
Langer, Controlled release of macromolecules, Chem. Tech., 12:98-105 (1982).
Lowman et al., Selecting high-affinity binding proteins by monovalent phage display, Biochemistry, 30(45):10832-7 (1991).
Löffler et al., A recombinant bispecific single-chain antibody, CD19 x CD3, induces rapid and high lymphoma-directed cytotoxicity by unstimulated T lymphocytes, Blood, 95(6):2098-103 (2000).
MacCallum et al., Antibody-antigen interactions: contact analysis and binding site topography, J. Mol. Biol, 262(5):732-45 (1996).
Mack et al., A small bispecific antibody construct expressed as a functional single-chain molecule with high tumor cell cytotoxicity, PNAS, 92(15):7021-25 (1995).
Mack et al., Biologic properties of a bispecific single-chain antibody directed against 17-1A (EpCAM) and CD3: tumor cell-dependent T cell stimulation and cytotoxic activity, J. Immunol., 158(8):3965-70 (1997).
Malmborg et al., BlAcore as a tool in antibody engineering, J. Immunol. Methods, 183(1):7-13 (1995).
Marks et al., By-passing immunization. Human antibodies from V-gene libraries displayed on phage, J. Mol. Biol., 222(3):581-97 (1991).
Martin et al., Irreversible coupling of immunoglobulin fragments to preformed vesicles. An improved method for liposome targeting, J. Biol. Chem., 257(1): 286-8 (1982).
Martin et al., Structural families in loops of homologous proteins: automatic classification, modelling and application to antibodies, J. Mol. Biol, 263(5):800-5 (1996).
Mather et al., Culture of testicular cells in hormone-supplemented serum-free medium, Annals N. Y Acad. Sci., 383:44-68 (1982).
Mather, Establishment and characterization of two distinct mouse testicular epithelial cell lines, Biol. Reprod., 23: 243-52 (1980).
Mendez et al., Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice, Nature Genetics, 15(2):146-56 (1997).
Milic et al., Ectopic Expression of P-Cadherin Correlates with Promoter Hypomethylation Early in Colorectal Carcinogenesis and Enhanced Intestinal Crypt Fission In vivo, Cancer Res., 68(19):7760-8 (2008).
Morrison et al., Chimeric human antibody molecules: mouse antigen-binding domains with human constant region domains, Proc. Natl. Acad. Sci. USA, 81(21):6851-5 (1984).
Morrison et al., Combinatorial alanine-scanning, Cur Opin Chem Biol., 5(3):302-7 (2001).
Morrison, Transfectomas provide novel chimeric antibodies, Science, 229(4719):1202-7 (1985).
Naghavi et al., Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013, Lancet, 385:117-71 (2015).
Needleman et al., A general method applicable to the search for similarities in the amino acid sequence of two proteins, J. Mol. Biol. 48(3):443-53 (1970).
Nolan et al., Fluorescence-activated cell analysis and sorting of viable mammalian cells based on beta-D-galactosidase activity after transduction of Escherichia coli lacZ, Proc. Natl. Acad. Sci. U.S.A. 85(8):2603-7 (1988).
Nose et al., A Novel Cadherin Cell Adhesion Molecule: Its Expression Patterns Associated with Implantation and Organogenesis of Mouse Embryos, J. Cell. Biol., 103:2649-58 (1986).
Oi et al., Chimeric Antibodies, BioTechniques, 4:214 (1986).
Olsson et al., Human-Human Hybridoma Technology, Meth. Enzymol., 92:3-16 (1982).
Owen et al., Synthesis of a functional anti-phytochrome single-chain Fv protein in transgenic tobacco, Bio/Technology, 10(7): 790-4 (1992).
Padlan, Anatomy of the Antibody Molecue, Molecular Immunology, 31(3):169-217 (1993).
Pall, The next-generation ALK inhibitors, Curr Opin Oncol., 27(2):118-24 (2015).
Parades et al., Biochimica et Biophysica Acta 1826, 297-311 (2012).
Parades et al., P-Cadherin Is Up-Regulated by the Antiestrogen ICI 182,780 and Promotes Invasion of Human Breast Cancer Cells, Cancer Res., 64:8309-17 (2004).
Parades et al., P-Cadherin Overexpression Is an Indicator of clinical Outcome in Invasive Breast Carcinomas and Is Associated with CDH3 Promoter Hypomethylation, Clin Cancer Res., 11(16):5869-77 (2005).
Patel et al., Cadherin switching in ovarian cancer progression, Int. J. Cancer, 106(2):172-7 (2003).
Pearson et al., Improved tools for biological sequence comparison, Proc. Nat. Acad. Sci. U.S.A., 85:2444-8 (1988).
PeraltaSoler et al., P-Cadherin Expression in Breast Carcinoma Indicates Poor Survival, Cancer, 86:1263-72 (1999).
Presta, Antibody engineering, Curr. Op. Struct Biol., 3(4):593-6 (1992).
Raag et al., Single-chain Fvs., FASEB, 9(1), 73-80 (1995).
Rader, DARTs take aim at BiTEs, Inside Blood, 117(17): 4403-5 (2011).
Radice et al., Precocious mammary gland development in P-cadherin-deficient mice, J. Cell Biol., 139: 1025-32 (1997).
Randolph et al., Surfactant-protein interactions, Pharm Biotechnol. 13:159-75 (2002).
Reichmann et al., Low neurotrophin receptor CD271 regulates phenotype switching in melanoma, Nature, 8:1-16(1988).
Remington's Pharmaceutical Sciences, 18 Edition, (A.R. Genrmo, ed.), (1990).
Root et al., Development of PF-06671008, a highly potent Anti-P-cadherin/Anti-CD3 bispecific DART molecule with extended half-life for the treatment of cancer, Antibodies. 5:1-30 (2016).
Sambrook et al., Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, 2001).
Schier et al., Efficient in vitro affinity maturation of phage antibodies using BIAcore guided selections, Human Antibodies Hybridomas, 7(3):97-105 (1996).
Schlereth et al., T-cell activation and B-cell depletion in chimpanzees treated with a bispecific anti-CD19/anti-CD3 single-chain antibody construct, Cancer Immunol. Immunother., 55: 503-14 (2005).
Shimoyama et al., Cadherin cell-adhesion molecules in human epithelial tissues and carcinomas, Cancer Res., 49(8):2128-33 (1989).
Sidman et al., Controlled release of macromolecules and pharmaceuticals from synthetic polypeptides based on glutamic acid, Biopolymers, 22(1):547-56 (1983).
Smith et al., Comparison of Biosequences, Adv. Appl. Math. 2:482-9 (1981).
Songsivilai et al., Bispecific antibody: a tool for diagnosis and treatment of disease, Clin. Exp. Immunol. 79(3):315-21 (1990).
Stauber et al., Development and applications of enhanced green fluorescent protein mutants, Biotechniques, 24:462-471 (1998).
Stefansson et al., Prognostic impact of alterations in P-cadherin expression and related cell adhesion markers in endometrial cancer, J. Clin. Oncol., 22(7):1242-52 (2004).
Sugiyama et al., A large-scale gene expression comparison of microdissected, small-sized endometrial cancers with or without hyperplasia matched to same-patient normal tissue, Clin Cancer Res., 9(15):5589-600; (2003).
Sun et al. P-Cadherin Promotes Liver Metastasis and Is Associated with Poor Prognosis in Colon Cancer, Am J Pathol., 179:380-90 (2011).
Sun et al., Side Effects of Chemotherapy, Anticancer Agents Med Chem., (2015).
Takeda et al., Construction of chimaeric processed immunoglobulin genes containing mouse variable and human constant region sequences, Nature, 314(6010):452-4 (1985).
Takeichi, The cadherins: cell-cell adhesion molecules controlling animal morphogenesis, Development, 102:639-55(1988).
Taniuchi et al., Overexpressed P-Cadherin/CDH3 Promotes Motility of Pancreatic Cancer Cells by Interacting with p120ctn and Activating Rho-Family GTPases, Cancer Res., 65:3092-9 (2005).
Teng et al., Construction and testing of mouse—human heteromyelomas for human monoclonal antibody production, Proc. Natl. Acad. Sci. U.S.A., 80(23):7308-12 (1983).
Thotakura et al., Enzymatic deglycosylation of glycoproteins, Meth. Enzymol., 138:350-9 (1987).
Tol et al., Monoclonal antibodies in the treatment of metastatic colorectal cancer: a review, Clin Ther., 32(3):437-53 (2010).
Tomlinson et al., The human immunoglobulin VH repertoire, Immunol Today, 16(5):237-42 (1995).
Tomlinson et al., The repertoire of human germline VH sequences reveals about fifty groups of VH segments with different hypervariable loops, J. Mol. Biol., 227(3):776-98 (1992).
Tomlinson et al., The structural repertoire of the human VK domain, EMBO Journal, 14:4628-38 (1995).
Torre et al., Global Cancer Statistics, 2012, CA Cancer J Clin., 65:87-108 (2015).
U.S. Appl. No. 07/466,008, Kucherlapati et al.
U.S. Appl. No. 07/574,748, Kay et al.
U.S. Appl. No. 07/575,962, Lonberg et al.
U.S. Appl. No. 07/610,515, Kucherlapati et al.
U.S. Appl. No. 07/904,068, Lonberg et al.
U.S. Appl. No. 07/919,297, Kucherlapati et al.
U.S. Appl. No. 08/112,848, Kucherlapati et al.
U.S. Appl. No. 08/155,301, Lonberg et al.
U.S. Appl. No. 08/161,739, Lonberg et al.
U.S. Appl. No. 08/165,699, Lonberg et al.
U.S. Appl. No. 08/209,741, Lonberg et al.
U.S. Appl. No. 08/234,145, Kucherlapati et al.
U.S. Appl. No. 08/376,279, Kucherlapati et al.
U.S. Appl. No. 08/430,938, Kucherlapati et al.
U.S. Appl. No. 08/462,837, Kucherlapati et al.
U.S. Appl. No. 08/463,191, Kucherlapati et al.
U.S. Appl. No. 08/464,584, Kucherlapati et al.
U.S. Appl. No. 08/486,853.
U.S. Appl. No. 08/486,859.
U.S. Appl. No. 08/759,620, Jakobovits et al.
Urlaub et al., Isolation of Chinese hamster cell mutants deficient in dihydrofolate reductase activity, Proc. Natl. Acad. Sci. USA, 77(7):4216-20 (1980).
VanRoy, Beyond E-cadherin: roles of other cadherin superfamily members in cancer, Nature Rev., V14(2):121-34 (2014).
Wei et al., Validation and target gene screening of hsa-miR-205 in lung squamous cell carcinoma, Chin Med J (Engl)., 127:272-8 (2014).
Yagi, et al.,Cadherin superfamily genes : functions, genomic organization, and neurologic diversity, Genes Dev., 14:1169-80 (2000 ).
Yang et al., Inhibition of insulitis and prevention of diabetes in nonobese diabetic mice by blocking L-selectin and very late antigen 4 adhesion receptors, Proc. Natl. Acad. Sci. U.S.A., 90(22):10494-8 (1993).
Yao et al., Research Progress of anti-CD3/anti-tumor antigen bispecific antibody mediated T lymphocyte anti-tumor effect and mechanism, Chinese Journal of Cancer Biotherapy. 12:237-9 (2005).
Zhang et al., PF-03732020: A Fully Human Monoclonal Antibody against P-Cadherin with Antitumor and Antimetastatic Activity, Clin Cancer Res., 16(21):5177-88 (2010).